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ribonucleic acid components of murine sarcoma and leukemia viruses.defective kirsten murine sarcoma virus was present as leukemia virus pseudotype [ki-msv(mlv)] in a 10- to 100-fold excess over its helper, kirsten murine leukemia virus (ki-mlv), when the two viruses were propagated in an nrk rat cell line. the s(omega,20) of the fastsedimenting rna complex of ki-mlv and of ki-msv-(mlv) was 62 s and 55 s, respectively. gel electrophoresis in buffered aqueous or formamide solution of the dissociated 62s rna complex of ki-mlv showed a single major peak of molecula ...19734357879
rescue of the murine sarcoma virus genome from non-producer cells by the rd-114 type c virus. 19724358036
strandedness and complementarity of dna from long-term rna-dependent dna polymerase reactions of soehner-dmochowski murine sarcoma virus.the dna product of the endogenously instructed rna-dependent dna polymerase reaction of murine sarcoma virus continued to be synthesized for as long as 64 h in the presence of 0.008% triton x-100. higher detergent concentrations and actinomycin d inhibited dna product synthesis. the dna product from long-term polymerase reactions consisted of small dna fragments as shown by sedimentation in alkaline sucrose gradients. the enzymatic dna product was separated into a slow sedimenting fraction and a ...19734358160
murine virus-induced proteins synthesized by hamster tumor cells transformed by, but not producing, murine sarcoma virus.the 8303 hamster tumor cells transformed by moloney strain of murine sarcoma virus (m-msv), but which do not produce virus, do contain murine virus-induced proteins. the virus-induced proteins within the cell were identified either as free proteins or in association with membranous material, including the plasma membrane. in addition, some were excreted by the 8303 hamster tumor cells into the growth medium. most virus-induced proteins were larger than 68,000 daltons, and they did not dissociate ...19744359302
deoxyglucose transport of uninfected, murine sarcoma virus-transformed, and murine leukemia virus-infected mouse cells. 19734359535
control of gene expression in rat cells transformed by a cold-sensitive murine sarcoma virus (msv) mutant. 19734359760
properties of noninfectious and transforming viruses released by murine sarcoma virus-induced hamster tumor cells.the cell culture lines htg2 and htg3 were established from a transplantable hamster tumor induced by a murine sarcoma virus (strain gz-msv) after 17 and 60 in vivo passages, respectively. the viruses released by these two cell lines markedly differ in morphology, antigenic composition, infectivity, transforming ability, and enzymatic activity. htg2 virions contained the sarcoma genome but were noninfectious for mouse and hamster cells (s+h-virus). htg3 virions transformed hamster but not mouse c ...19734359960
effects of stas jlsv5 and silicotungstate on the replication of murine sarcoma virus (moloney) and poliovirus. 19734360170
recovery of the genome of murine sarcoma virus (msv) after infection of cells with nuclear dna from msv transformed non-virus producing cells. 19734360277
evidence for in vivo protection against murine-sarcoma virus-induced tumors by t lymphocytes from immune animals. 19744360545
comparative in vitro studies on effector cell diversity in the cellular immune response to murine sarcoma virus (msv)-induced tumors in mice. 19744360862
absence of a specific ganglioside galactosyltransferase in mouse cells transformed by murine sarcoma virus.the ganglioside composition of a nonproducer subclone (derived from balb/c 3t3 mouseembryo cells) transformed by kirsten murine sarcoma virus was drastically altered compared to the nontransformed parental clone. the transformed clone was unable to synthesize the mono- and disialogangliosides, g(m1) and g(d1a), due to the complete absence of a specific galactosyltransferase. the lack of this enzyme activity was established by sensitive radiochemical and enzymological techniques in vivo and in vi ...19744360937
heterogeneity of virus production and antigenicity detected in cell clones derived from a "nonproducer" neoplasm induced by moloney murine sarcoma virus. 19744361177
morphologic revertants of murine sarcoma virus transformed nonproducer balb-3t3: selective techniques for isolation and biologic properties in vitro and in vivo. 19744361451
properties of flat variants of murine sarcoma virus transformed non-producer cells isolated after high-temperature passage. 19744361650
immunity to murine sarcoma virus-inducted tumors. i. specific t lymphocytes active in macrophage migration inhibition and lymphocyte transformation. 19744361977
immunity to murine sarcoma virus-inducted tumors. ii. suppression of t cell-mediated immunity by cells from progressor animals. 19744361978
non-infectious intracisternal a-type particles in a sarcoma-positive, leukemia-negative mouse cell line transformed by murine sarcoma virus (msv). 19734362933
activation of the murine sarcoma virus genome after infection with the murine leukemia virus as determined by cell agglutination.non-virus-producing nih/3t3 cells transformed by the murine sarcoma virus are agglutinated by conconavalin a to the same low level as normal nih/3t3 cells. infection with the murine leukemia virus greatly increases the agglutination of transformed cells but not that of normal cells. these data suggest that the morphological expression of cell transformation and the surface alterations associated with increased cell agglutination are controlled by the expressions of different sarcoma virus genes.19744363245
temperature-dependent alterations in 2-deoxyglucose uptake in rat cells transformed by a cold-sensitive murine sarcoma virus mutant. 19734364262
fucosylglycolipids in cells transformed by a temperature-sensitive mutant of murine sarcoma virus. 19744364434
differences in cytochalasin b inhibition of 3-o-methylglucose uptake between balb-3t3 cells and a murine sarcoma virus transformed clone. 19734364793
the histogenesis of tumours induced in golden hamsters by murine sarcoma virus-harvey (msv-h). 19734364799
murine sarcoma virus-induced cytopathological effects in mouse cells made resistant to 6-azauridine. 19744364879
harvey sarcoma virus: a second murine type c sarcoma virus with rat genetic information.the nucleic acid sequences found in the harvey strain of murine sarcoma virus have been analyzed by rna.[(3)h]dna and [(3)h]rna.dna hybridization techniques. the harvey strain of murine sarcoma virus has been found to possess at least two sets of nucleic acid sequences. one set of sequences is contained in the moloney strain of mouse type-c virus, and the other set is contained in dna transcripts synthesized in endogenous reactions containing rat type-c virus(es). the nucleic acid sequences that ...19744364897
simple, quantitative assay for both xenotropic murine leukemia and ecotropic feline leukemia viruses.a cat cell line carrying the genome of a murine sarcoma virus developed discrete foci in linear response to infection with feline leukemia virus or xenotropic murine c-type virus.19744365331
temperature-dependent expression of transformation by cold-sensitive mutant of murine sarcoma virus.morphological transformation of normal rat kidney cells by a murine sarcoma virus was found to be cold-sensitive. cells transformed by the virus expressed their transformed phenotype at the permissive temperature (39 degrees ) but not at the nonpermissive temperature (33 degrees ), as judged by the criteria of morphological changes and colony-forming ability on monolayers of normal rat kidney cells. cold-sensitive expression of transformation was specific for focus-derived normal rat kidney cell ...19734365365
mutants of nonproducer cell lines transformed by murine sarcoma virus. 3. detection and characterization of rna specific for helper and sarcoma viruses.balb/3t3 cells transformed by the kirsten sarcoma virus (nonvirus producer balb/3t3 cells) and mutant cell lines derived therefrom by treatment with bromodeoxyuridine (brdu) were analyzed for expression of virus-specific rna using single-stranded dna transcripts of rauscher leukemia virus (rlv), a virus activated in one of the cell lines (58-2t), and ki-sv-specific dna transcript; the latter transcript after removal of all sequences cross-reactive with rlv rna. the rauscher virus dna detected mu ...19744365514
spontaneous induction of endogenous murine leukemia virus-related antigen expression during short-term in vitro incubation of mouse lymphocytes.short-term lymphocyte cultures from mouse thymus, spleen, or lymph nodes were studied for the presence of murine leukemia virus group-specific antigens with an immunofluorescence test using rat immune sera against syngeneic cells infected with the radiation leukemia virus or its pseudotype of murine sarcoma virus and goat and rabbit antisera against purified murine leukemia virus group-specific antigen. antigens reacting with these sera appeared in the cultured lymphocytes within 24 hr, and the ...19744365582
growth-and density-dependent inhibition of deoxyglucose transport in balb 3t3 cells and its absence in cells transformed by murine sarcoma virus.the earliest measurable parameter that shows density-dependent inhibition is the uptake of [(3)h]deoxyglucose by balb 3t3 cells. the rate decreases even during the exponential phase of growth and reaches a minimum, about 8- to 10-times lower than maximum, as the culture approaches the saturation density. cells transformed by murine sarcoma virus fail to show either growth-dependent or density-dependent inhibition of deoxyglucose uptake. treatment with dibutyryl cyclic amp in the presence of theo ...19734365700
oncornavirus expression in human x mouse hybrid cells segregating mouse chromosomes.human x mouse hybrid clones obtained by fusing transformed human (va2) cells with embryonic mouse brain cells were tested for their ability to spontaneously express type c virus particles. it had been previously shown that these hybrid cells preferentially retained human chromosomes while mouse chromosomes were lost. the culture fluid from one cell line was found to contain type c particle markers in abundance, and typical budding c particles were observed in the cells by electron microscopy. in ...19744366059
cell culture from a rat brain tumor induced by intracerebral inoculation with murine sarcoma virus. 19744367241
suppression of chemically induced pulmonary tumors by treatment of strain a mice with murine sarcoma virus. 19744367245
effect of histone on oncogenic properties of moloney's murine sarcoma virus. 19734367375
[action of distamycin a and its derivatives on the moloney murine sarcoma virus in vitro and in vivo]. 19744368047
deoxyglucose transport changes in murine sarcoma virus-infected cells-a quantitative assay for virus transforming activity. 19744368568
the specificity of dimethylbenzylrifampicin as an inhibitor of viral induced transformation.the effect of 2',6'-dimethyl-n(4')-benzyl-n(4')- [desmethyl]rifampicin on viral transformation induced by two unrelated oncogenic viruses was compared. transformation of balb/3t3 cells by the small, dna-containing papova virus simian virus 40 was completely normal under conditions where transformation by the large, rna-containing oncornavirus murine sarcoma virus was inhibited more than 150-fold. for these experiments a resistant variant of balb/3t3 was selected that grows well in high concentra ...19744369359
effect of tissue injury on tumorigenesis induced by murine sarcoma virus (harvey). 19744369962
murine sarcoma virus gene expression: transformants which express viral envelope glycoprotein in the absence of the major internal protein and infectious particles.expression of the major internal protein and the envelope glycoprotein of murine c-type viruses in focus-derived lines of normal rat kidney cells infected with kirsten murine sarcoma virus was measured by radioimmunoassay. of the clones selected, which do not produce virus particles or the major viral structural protein, approximately half express the viral envelope glycoprotein at concentrations found in productively infected cells. expression of the envelope glycoprotein did not appear to alte ...19744370209
ultrastructure of tumors induced in mice by moloney and harvey strains of murine sarcoma virus. 19744370536
isolation and characterization of revertant cell lines. vi. susceptibility of revertants to retransformation by simian virus 40 and murine sarcoma virus.the susceptibility of two classes of revertants of simian virus 40 (sv40)-transformed 3t3 cells to retransformation by sv40 or murine sarcoma virus (msv) was studied. both serum-sensitive and density-sensitive revertants are not retransformable by sv40. msv can transform both types of revertants. the msv-transformed revertants grow to high cell densities and form colonies when suspended in semi-solid methylcellulose medium, but are unable to grow in 1% calf serum. the msv-transformed revertants ...19744372404
immunological responsiveness in rats infected with the soehner-dmochowski murine sarcoma virus (msv-sd). 19744372740
inhibition by ethidium bromide of the establishment of infection by murine sarcoma virus. 19744373527
aspects of harvey murine sarcoma virus complex. 19704376364
neoplastic bone lesions induced in rats and hamsters by moloney and harvey murine sarcoma viruses. 19704376388
cell-surface antigens of murine sarcoma-virus-transformed non-producer cells: further evidence for lack of transplantation immunity. 20144376511
the growth of transplanted tumours in mice after chronic inhalation of fresh cigarette smoke.the subcutaneous growth of the lewis lung tumour in c57bl mice chronically exposed to fresh cigarette smoke was increased above that in age-matched control mice. when murine sarcoma virus (harvey) induced tumour cells were introduced to the lungs of groups of balb/c mice, only mice chronically exposed to fresh cigarette smoke died with tumour cells in the lungs. tumour cell growth in mice during short term cigarette smoke exposure was indistinguishable from that in controls.19744377708
isolation and characterization of "8s" rna in murine sarcoma virus-infected cells. 19744473984
induction of rat osteosarcoma by inoculation of murine sarcoma virus into bone marrow. 19724505011
different neoplastic response of mice and rats to infection by murine sarcoma virus (moloney). 19724507708
establishment of a virus-persistent cell line and deviation of malignant cell clones from rat osteosarcoma induced by a murine sarcoma virus (moloney). 19724507709
sugar effects on murine sarcoma virus transformation.transformation of nih swiss mouse fibroblasts by a murine sarcoma virus was influenced by the type of carbohydrate in the culture medium. exposure to d-mannose and 2-deoxy-d-glucose caused a reduction in the number of transformed colonies in vitro and tumor formation in vivo. this is a new type of interference in the transformation process, manifested also by the absence of the pronounced enhancement of hexose entry into transformed cells, characteristic of a sarcoma virus infection. the uptake ...19734514307
tumour-associated transplantation antigens of neoplasms induced by a naturally occurring murine sarcoma virus (fbj-msv). 19734516007
transformation of swiss 3t3 cells by murine sarcoma virus is followed by decrease in a glycolipid glycosyltransferase. 19734518362
effect of antibody to theta antigen on cell-mediated immunity induced in syngeneic mice by murine sarcoma virus. 19734543478
immunity to murine sarcoma virus induced tumours. 3. analysis of the cell populations involved in protection from lethal tumour progression of sublethally irradiated, msv inoculated, mice. 19744547542
antigenic properties of murine sarcoma virus-transformed balb-3t3 nonproducer cells.the isolation of clonal lines of murine sarcoma virus-transformed, non-producer balb/3t3 cells has provided a model system for determining whether rna tumor virus-transformed cells possess virus-specific transplantation antigens. msv nonproducer cells (k-234) were clonally derived from an inbred mouse cell line, balb/3t3. a parallel virus-producing cell line was obtained by infection of the msv nonproducer cells with rauscher leukemia virus. k-234 was much more tumorigenic than k-234(r). preimmu ...19724550769
studies on murine sarcoma virus. 3. synthesis of the viral antigens in cells of various species. 19724554131
enhanced growth of a murine coronavirus in transformed mouse cells.plaque formation by a59 virus, a murine coronavirus, was facilitated in al/n and balb mouse cells transformed by polyoma virus, simian virus 40, murine sarcoma virus, or mammary tumor virus. in these virus-transformed cells, a59 virus plaques were larger, they appeared earlier, and plaquing efficiencies were higher than in normal, untransformed cells. "spontaneously" transformed al/n cells behaved similarly to untransformed cells, whereas "spontaneously" transformed balb cells resembled virus-tr ...19724564284
tumor induction by murine sarcoma virus in akr and c58 mice. reduction of tumor regression associated with appearance of gross leukemia virus pseudotypes.adult akr and c58 mice injected intramuscularly with murine sarcoma virus, moloney isolate (m-msv), developed high incidence of nonregressing local tumors. histologically, these tumors revealed the typical pleomorphism of m-msv sarcomas; in some cases, however, neoplastic tissue showed a nodular or diffuse growth of monomorphic myoblastlike cells, reminiscent of clonal aggregates. no depression of immune reactivity was found in m-msv-injected mice as evaluated by direct hemolytic plaque-forming ...19744608945
effects of daunomycin and adriamycin on the murine sarcoma virus (moloney) in vitro. 19724647914
epithelial features of "nonproducer" balb-3t3 cells transformed by murine sarcoma virus. 19724650203
the effect of immunosuppression on oncogenesis by murine sarcoma virus. 19724672103
senescent loss of resistance to murine sarcoma virus (moloney) in the mouse. 19734748428
in vitro cytotoxicity studies of murine sarcoma virus-induced immunity in mice. 19734762933
metyrapone-inhibited oncogenesis in mice inoculated with a murine sarcoma virus. 19734765394
in utero tumor induction by murine sarcoma virus (moloney) in the rat. i. biological characteristics. 19734791222
tumour regression and relapse in mice inoculated with murine sarcoma virus (moloney). 19734795193
prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice. 19734795530
antigens of tumours induced by naturally occurring murine sarcoma virus (msv-fbj). i. detection of group and type specific antigens by complement fixation. 19744820943
evidence for helper-independent murine sarcoma virus. ii. differences between the ribonucleic acids of clone-purified leukemia virus, helper-independent and helper-dependent sarcoma viruses. 19744833544
differences between murine leukemia virus and murine sarcoma virus: effects of virion age and multiplicity of infection on viral rna. 19744851372
intracellular viral rna species in mouse cells nonproductively transformed by the murine sarcoma virus.the size and quantity of virus-specific rna in five non-virus-producing mouse cells transformed by the moloney isolate of murine sarcoma virus (msv) was determined. hybridization of rna from transformed cells with the [(3)h]dna product of the rna-directed dna polymerase of the murine sarcoma-leukemia virus was used to detect and quantitate virus-specific rna. the amount of virus-specific rna in non-virus-producing cells was less than one-sixth of that found in virus-producing cells. a striking c ...19744852536
effect of cortisone on oncogenesis by murine sarcoma virus (moloney). 19684867925
studies on murine sarcoma virus: antigenic characterization of murine sarcoma virus induced tumor cells. 19694899685
inhibition of murine sarcoma virus oncogenesis with living bcg. 19714943924
[stimulative interaction between murine sarcoma virus and murine hepatitis virus]. 19684968740
[ribonucleic acid of high molecular weight isolated from murine sarcoma virus (moloney strain)]. 19684968761
[replication of the murine sarcoma virus maloney strain on bovine embryo cells]. 19684970677
[nature of competent viral particles contained in murine sarcoma virus stocks, moloney strain]. 19694983277
[demonstration of bicatenar rna in a cellular line transformed and chronically infected by murine sarcoma virus]. 19704987723
studies on murine sarcoma virus. ii. detection of group-specific antigens by immunofluorescence. 19714993663
[action of actinomycin d on cell conversion induced by the murine sarcoma virus, moloney isolate]. 19714997223
enhancement and suppression of murine sarcoma virus induced tumors by polyriboinosinic-polyribocytidylic acid. 19725007472
lack of distinctive surface antigen on cells transformed by murine sarcoma virus.some murine sarcoma virus (msv)-transformed mouse 3t3 cells contain the msv genome in the absence of infectious helper murine leukemia virus (mulv) and msv production. these cells, designated s+l- (sarcoma positive, leukemia negative), were analyzed for the presence of a possible msv-determined membrane antigen by the mixed hemadsorption test and in vitro lymphocyte cytotoxicity assay. two different serological approaches were used: (a) isoantibody-free sera were obtained by immunizing with msv ...19725043415
synthetic rna and dna polynucleotides: in vivo and in vitro enhancement of oncogenesis by a murine sarcoma virus. 19725057579
hypogammaglobulinaemia and lipaemia initiated by the murine sarcoma virus (moloney) in rats. 19725081216
comparative pathology and ultrastructure of rodent sarcomas induced by the murine sarcoma virus (moloney). 19715091659
recovery of moloney murine sarcoma virus added to bovine milk. 19715101994
interference of daunomycin and adriamycin on the growth and aggression of murine sarcoma virus (moloney) tumors in mice. 19715120294
[resistance of akr mice to the oncogenic action of moloney murine sarcoma virus]. 19715126159
quantitative interactions of feline leukaemia virus and its pseudotype of murine sarcoma virus in cat cells: requirement for dna synthesis. 19715157829
virus-induced sarcoma of mice: inhibition by a synthetic polyribonucleotide complex.the availability of a potent inducer of interferon, the synthetic double-stranded rna (poly i.poly c), prompted us to determine its possible prophylactic and/or therapeutic effect on virus-induced sarcomas of mice. when treatment was begun prior to virus inoculation and repeated on alternate days, the majority of nih swiss mice inoculated with moloney or friend pseudotypes of moloney murine sarcoma virus failed to develop tumors. other experiments suggested that repeated injections initiated eve ...19695256404
induction of bone tumours in rats and hamsters with murine sarcoma virus and their cell-free transmission. 19695259233
acceleration by thymosin of the development of resistance to murine sarcoma virus-induced tumor in mice.the development of resistance to progressive tumor growth and the effect of a thymic extract upon this developmental process were examined in cba/wh mice. inoculating mice of various ages with murine sarcoma virus (moloney) permitted the assessment of the period of time postnatally at which the animals developed a threshold level of resistance to progressive tumor growth. resistance in cba/wh mice, at the virus dose used, was first detected at approximately two weeks of age and was completely de ...19705273447
a spleen weight assay for murine sarcoma virus harvey (msv-h). 19695346883
enhancement of murine sarcoma virus (moloney) infection and tumorigenesis in vivo by coinfection with rauscher leukemia virus. 19695358213
effectiveness of therapy with a multistranded synthetic polynucleotide complex against a murine sarcoma virus.a known interferon stimulator, polyriboinosinic acid:polyribocytidylic acid (ri:rc), was shown to have a protective effect against a highly tumorigenic variant of the murine sarcoma virus (moloney) designated as (msv-pv). mice treated intraperitoneally with different regimens of ri:rc survived significantly longer than untreated controls. the treatment was effective whether the infection with msv-pv was intraperitoneal or intracerebral. the antiviral effectiveness of ri:rc was demonstrated by ma ...19695373679
pathological effects in hamsters of murine sarcoma virus (msv harvey). 19705420785
histochemical and electron-microscopic studies of multinnucleate cells in hamster tumours induced by murine sarcoma virus (ms harvey). 19705420786
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