Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [infection due to hepatitis b virus and host immune response]. | cell-mediated immunity (cmi) to hepatitis b surface antigen (hbsag) was investigated in patients who recovered from acute hepatitis b and in chronic carriers of the antigen, either with or without liver disease. the study was performed using leucocyte migration inhibition test and purified hbsag. in antigen-negative post-hepatitis patients the frequency of cellular immunity to hbsag (63.6%) showed a significant difference to controls. on the other hand, only one out of 5 antigen-positive post-he ... | 1976 | 1016586 |
| [liver-specific proteins and autoimmunity in inflammatory liver diseases]. | cell-mediated immunity to a liver specific membrane protein (lp1) has been studied in patients with different types of liver diseases, using the leucocyte migration inhibition test. a high frequency of cellular sensitization to lp1 was detected in untreated chronic active hepatitis, with no significant differences between hbsag-positive and negative cases. inhibition of migration is a long-lasting reaction in the spontaneous evolution of the disease, while immunosuppressive treatment normalizes ... | 1976 | 1016592 |
| [behavior of hbs ag and hbs ab in chronic hepatitis]. | the preliminary results of the hb, ag and hbs ab assay, performed with radioimmunological techniques in 31 cases of chronic hepatitis, 13 of whom carriers of chronic aggressive hepatitis (c.a.h.), 9 of chronic persistent hepatitis (c.p.h.) and 9 of cryptogenetic hepatic cirrhosis (c.h.c.) of both sexes, are reported. the highest number of hbs ag positive cases was observed both in c.a.h. (69%) and c.h.c. (55%); very lower the hbs ag positivity both in c.a.h. (33%) and c.h.c. (33%). no correlatio ... | 1976 | 1023884 |
| new approach, facts and hypothesis on b virus hepatitis epidemiology and pathogenesis. | 1976 | 1027957 | |
| evidence against the postulated identity of e-antigen with dna polymerase associated with the hepatitis b candidate virus. | partially purified preparations of e-antigen, obtained from sera of hepatitis b antigen carriers, were chromatographed on columns of immobilized single- or double-stranded dna or on pyran-sepharose. e-antigen did not adsorb to any of these columns under conditions appropriate for the retention of various nucleic acid polymerases. therefore, e-antigen and the dna polymerase associated with dane particles can be regarded as distinct proteins. | 1976 | 1030694 |
| detection of core antibody in hepatitis b infection. | hepatitis b core antigen (hbcag) is found on the decoated dane particle and on a morphologically similar particle detected mainly in the nucleus of hepatocytes of patients with hepatitis b. hbcag prepared from the liver of a chimpanzee infected with hepatitis b virus was used to test human serum for core antibody (anti-hbc) by complement fixation. anti-hbc was found in serum collected from patients with hepatitis b in both the acute and convalescent stages, from carriers of hepatitis b surface a ... | 1976 | 1032591 |
| [comparative study of antigens specific for hepatitis b in transfected cell cultures]. | a comparative study of antigens detected in the livers of patients with hepatitis b. in the mesonephros of the human tissue--chick embryo system infected with the agents isolated from the blood of hepatitis patients, as well as antigens detectable in cell cultures transfected by the dna isolated from these tissues was carried out. the results are in favour of the hypothesis on the integrational nature of serum hepatitis. | 1976 | 1034374 |
| [significance of hepatitis b virus (hbv) infection in chronic hepatitis with special reference to cellular immunity]. | 1976 | 1034803 | |
| [hepatitis b: infective agent, infection transmission, infection recipient]. | 1976 | 1051035 | |
| experimental studies on environmental contamination with infected blood during haemodialysis. | to assess the relative importance of different postulated modes of spread of hepatitis b in dialysis units, blood charged with various tracer organisms was used in simulated haemodialysis runs in four laboratories, and the resulting contamination of equipment and environment was measured semi-quantitatively. some airborne spread of the tracer organism occurred when tubing containing contaminated blood was needled as the "patient" went on and came off the dialyser. virtually no small airborne par ... | 1975 | 1054057 |
| type b hepatitis bad news for the dentist. | 1975 | 1055119 | |
| genome of hepatitis b virus: restriction enzyme cleavage and structure of dna extracted from dane particles. | dna extracted from dane particles has been characterized by gel electrophoresis and restriction enzyme cleavage with endonuclease r-haeiii (from hemophilus aegyptius). dane particle dna is proposed to be a double-stranded circular dna approximately 3600 nucleotides in length containing a single-stranded gap of 600-2100 nucleotides. the endogenous dna polymerase (dna nucleotidyl-transferase; deoxynucleosidetriphosphate:dna deoxynucleotidyltransferase; ec 2.7.7.7) reaction appears to repair this s ... | 1975 | 1060140 |
| study design for a hepatitis b vaccine trial. | a short-time trial of small sample size for an evaluation of the hepatitis b vaccine is proposed and designed. the vaccine is based on the premise that antibody to the surface antigen of the hepatitis b virus is protective against viral infection. this premise is verified by using the presence of the surface antigen as the marker of infection and comparing infection rates in renal dialysis patients who had naturally acquired antibody to patients without antibody. patients with antibody have an e ... | 1976 | 1062809 |
| hepatitis b in australian aborigines and torres strait islanders: georgraphical, age and familial distribution of antigen subtypes and antibody. | hepatitis b antigen of subtype ay is prevalent in australian aboriginal populations, but only subtype ad was found in torres strait islanders. both subtypes were found in caucasion hepatitis patients and blood donors from brisbane. antigenaemia in aborigines was more prevalent in northern territory than in queensland, and in males in all areas, but different age distributions were found in queensland (maximal over 30 years) and northern territory (maximal under 30 years). family clustering was s ... | 1976 | 1067808 |
| [hepatitis-b-surface-antibodies (detection, incidence, clinical importance)]. | the ausria 2 test has been modified for hbs antibody detection. this technique is about 7 to 8 dilution steps more sensitive for antibody detection than the ipe. using this modified radioimmunological technique investigations have been carried out on blood donors, patients with acute and chronic liver disease and on haemophiliacs. an hbs antibody incidence of 11% was found among voluntary blood donors. intensive clinical investigation of blood donors positive for hbs antibodies by ipe demonstrat ... | 1976 | 1069404 |
| cell-mediated immune reactivity to hepatitis b surface antigen in liver diseases. | the cellular immune reactivity to hepatitis b surface antigen (hbsag) was studied in patients with liver diseases using a purified preparation of hbsag and the leukocyte-migration agarose test. inhibition of leukocyte migration by hbsag was found in all 9 patients in the acute phase of viral hepatitis but not during convalescence. hbsag inhibited migration of leukocytes in only 1 of 15 patients with chronic persistent hepatitis, in none of 16 with chronic periportal hepatitis, and in 2 of 21 wit ... | 1975 | 1080122 |
| cell-mediated immunity to hepatitis b surface antigen in blood donors with persistent antigenaemia. | cellular immunity to the hepatitis b surface antigen (hbsag) and a liver-specific lipoprotein was studied, using the leucocyte migration test, in 38 asymptomatic blood donors found to have hbsag in the serum. sensitization to hbsag was found in 26% and was related to the presence of liver damage, being detected in 47% of those with elevated serum aspartate aminotransferase but in only 13% with normal enzyme levels. the frequency of sensitization to this antigen in those with chronic persistent o ... | 1975 | 1080125 |
| editorial: after type b hepatitis. | 1975 | 1081418 | |
| immunopathology of hepatitis b antigen positive and negative active chronic hepatitis. | evidence is presented to suggest that an auto-immune response to a liver-specific lipoprotein antigen on the surface of hepatocytes is responsible for the progressive liver damage in active chronic hepatitis, and that in many cases infection with the hepatitis b virus is important in the initiation of the disease process. b cells appear to play a major role in the auto-immune response and may be activated by t cells reacting with viral antigens on the surface of infected hepatocytes. a postulate ... | 1975 | 1081961 |
| autoimmune factors in african cirrhosis. correlation with hepatitis b surface antigen and antibody. | sera were tested for autoantibodies in 98 patients with cryptogenic cirrhosis in uganda and results correlated with serological tests for hepatitis b surface antigen (hbs ag) and antibody to hbs ag (hbs ab). smooth muscle antibodies (sma) were detected in 23 (24%) of the patients but there was no difference in the incidence of sma between hbs ag-positive and negative cases. antinuclear antibodies (ana) were detected in five cases; mitochondrial, gastric and thyroid antibodies were not found in a ... | 1975 | 1083141 |
| mechanisms responsible for defective human t-lymphocyte sheep erythrocyte rosette function associated with hepatitis b virus infections. | the expression of selected lymphocyte surface-membrane markers was evaluated in 37 patients with acute viral hepatitis b, 10 of whom were studied serially through the resolving and convalescent phases of disease. bone marrow-derived (b) lymphocytes were identified by reference to surface immunoglobulin, whereas normal thymus-derived (t) lymphocytes were assayed by their capacity to form spontaneous nonimmune rosettes with sheep erythrocytes (e rosettes, er). during the acute and resolving phases ... | 1976 | 1083396 |
| t-lymphocyte number and function and the course of hepatitis b in hemodialysis patients. | to study the relation between general cellular immunity and the course of hepatitis b within a group of chronic hemodialysis patients, t-lymphocyte number and function were investigated in 13 persistently hepatitis b surface antigen (hbsag)-positive patients, in 32 hbsag-negative patients, and in 11 patients who had recovered from hepatitis b and compared with that of 21 age-matched controls. phytohemagglutinin-induced lymphocyte stimulation in vitro and the number of circulating t-cells in the ... | 1976 | 1086288 |
| type b and non-b viral hepatitis in jerusalem. | in a two-year survey of adult patients hospitalized with acute viral hepatitis in jerusalem, 27% were reactive for the hepatitis b surface antigen (hb(s)ag) by radioimmunoassay and therefore diagnosed as having hepatitis b. the majority of patients (73%) were non-reactive for hb(s)ag and their diagnosis was non-b hepatitis ("type unspecifiable"). thirty-one per cent of patients with hepatitis b and only 5% of patients with non-b hepatitis had histories consistent with parenteral transmission of ... | 1976 | 1088102 |
| [immunology of viral hepatitis and its complications]. | 1976 | 1088493 | |
| pattern of core and surface expression in liver tissue reflects state of specific immune response in hepatitis b. | a series of 67 liver biopsies (20 kidney transplant recipients and 47 outpatients with hepatitis) was investigated for the presence of hepatitis b antigen core (hbc) and surface (hbs) components by immunofluorescence and electron microscopy. the variable appearance of the core in liver cell nuclei and of the surface in the cytoplasm allowed the recognition of expression patterns which, together with histologic parameters, could be integrated into four reaction types of diagnostic and prognostic ... | 1975 | 1089835 |
| toward hepatitis b vaccines. | 1975 | 1091314 | |
| primary biliary cirrhosis. | 1975 | 1092489 | |
| thymus-derived lymphocytes in type b acute viral hepatitis and healthy carriers of hepatitis b surface antigen (hbsag). | to assess thymus-derived (t) lymphocyte function in hepatitis b infection, lymphocytes from patients with type b acute viral hepatitis and healthy carriers of the hepatitis b surface antigen, were compared to normal controlss using phytohemagglutinin (pha) -induced blast cell transformation and sheep-cell rosette formation. overall cell (t lymphocyte) -mediated immune function was similar with these in vitro assays in all three groups, except for decreases in total t cells in isolated patients w ... | 1975 | 1093393 |
| [advances in rheumatology. immunostimulation in rheumatoid diseases]. | 1975 | 1094431 | |
| hepatitis b antigens in serum and liver of chimpanzees acutely infected with hepatitis b virus. | we report the temporal patterns of various immunohistological and serological parameters of acute self-limited hepatitis b virus infection of two chimpanzees, and we provide evidence that the synthesis of hepatitis b core antigen precedes that of hepatitis b surface antigen. our data suggest that existence of a biphasic hepatitis b virus infection involving a hematogenous reinfection of the liver and indicate that recruitment of liver cells to produce hepatitis b virus may occur in a pattern con ... | 1975 | 1100525 |
| hepatitis b immune globulin as a prophylactic measure for spouses exposed to acute type b hepatitis. | because the value of usual immune globulin preparations in preventing type b hepatitis is doubtful, we carried out a double-blind comparison of a control human immune globulin preparation with one--identified as hbig--that had a high concentration (442 mug per milliliter) of antibodies to surface components of hepatitis b virus. effectiveness was tested in spouses of patients with acute type b hepatitis. within 150 days after injection, nine of 33 spouses in the control group had symptomatic typ ... | 1975 | 1101065 |
| editorial: hepatitis b immune globulin: evaluation of clinical trials and rationale for usage. | 1975 | 1101067 | |
| hepatic disease in asymptomatic parenteral narcotic drug abusers: a veterans administration collaborative study. | the veterans administration is currently conducting a collaborative study in three hospital-based drug treatment clinics to evaluate asymptomatic parenteral drug addicts for evidence of hepatic disease. preliminary data are presented on 347 patients who have completed at least three months of follow-up evaluation. on admission, abnormal serum transaminase values were demonstrated in one half, hbs ag in 7 per cent, and anti-hbs in 59 per cent. the frequency of these findings increased during the ... | 1975 | 1103622 |
| prevention of nosocomial viral hepatitis, type b (hepatitis b). | nosocomial viral hepatitis, type b, is assuming increasing importance in the united states. the keystone to an effective hepatitis control program is surveillance of patients and personnel, especially in high-risk areas, namely dialysis units, hematology-oncology units, and laboratories. measures to control infection are outlined for specific areas of the hospital. data currently available suggest that employees who have persisting hepatitis b surface antigen (hbsag) need not be removed from the ... | 1975 | 1106282 |
| familial clustering of hepatitis b surface antigen among panamanian indians. | several authors have suggested that the host genome determines the occurrence of chronic hbs ag (hepatitis b surface antigen). in attempts to evaluate this possibility, total infection rate and the combined frequencies of hbs ag and antibody to hbs ag and radioimmunoprecipitation to measure antibody to hbs ag, we tested sera from 255 panamanian guaymi indians. they represented 48 families and 32 living units. clusters of chronically antigenemic individuals were found in families. clusters of inf ... | 1975 | 1110308 |
| effects of cyclophosphamide on hepatitis b virus infection and challenge in chimpanzees. | the role of antibodies to the surface antigen of hepatitis b virus (hbsag) and to the hepatitis b core antigen (hbcag) and of cell-mediated immunity in hepatitis b virus infections and in resistance to challenge was studied in six chimpanzees. two chimpanzees were studied during primary hepatitis b virus infection while being treated with cyclophosphamide (5-15 mg/kg im three times per week). cyclophosphamide treatment may have predisposed these chimpanzees to chronic hepatitis b virus infection ... | 1975 | 1117192 |
| an epidemiologic study of hepatitis b virus in bangkok, thailand. | residents of a randomly selected sample of households in a low-income housing project in bangkok were studied between july 1971 and april 1972. prevalence of hepatitis b antigen (hbs ag) in july 1971 was 8.2% in 697 persons age one year and older and changed little with age. prevalence of antibody to hbs ag (anti-hbs) was much higher in all age groups and was 46% overall. the prevalence of hbs ag was higher in males than females from ages 10-29 years and the prevalence of anti-hbs was higher in ... | 1975 | 1124753 |
| cellular and humoral immunity to hepatitis-b surface antigen in active chronic hepatitis. | the hepatitis-b surface antigen (hbsag) may be persistently present in the serum in a few cases of active chronic hepatitis but the cause of the disease in most patients is unknown. in a study of 39 hbsag-negative cases cell-mediated immunity to hbsag was observed in 24 (62%), suggesting a high frequency of previous infection with the hepatitis-b virus. hepatitis-b surface antibody was detectable by radioimmunoassay in six patients, in all of whom complexes of hbsag were present in the serum on ... | 1975 | 1125673 |
| hepatitis b antibody. | 1975 | 1127931 | |
| letter: transmission of hepatitis by breast feeding. | 1975 | 1128616 | |
| rolling circular dna associated with dane particles in hepatitis b virus. | 1975 | 1128676 | |
| [evolution of the knowledge concerning homologous serum hepatitis]. | 1975 | 1145300 | |
| clinical and immunologic studies on blood donors with chronic asymptomatic infection with hepatitis type b virus (hbv). | 1975 | 1146607 | |
| [hepatitis b at the premonitory stage. incidence of articular and cutaneous manifestations, aprpos of 100 cases]. | hepatitis b in the prodromal phase. occurence of articular and cutaneous manifestations. concerning 100 cases, | 1975 | 1153296 |
| serologic evidence of hepatitis b virus infection in patients with hemophilia b. a multicenter study. | among sera from 160 patients with hemophilia b from 9 centers in europe and north and south america, 2.5% were positive for hepatitis b surface antigen (hbsag), 60for antibody to hbsag, and 31% for antibody to the hepatitis b core antigen. evidence of exposure to the hepatitis b virus appeared to be related to severity of disease and age rather than the source and method of manufacturer of factor ix concentrate. | 1975 | 1154315 |
| hepatitis b virus infection in dentists. | to evaluate viral hepatitis as a hazard in general dentistry, we surveyed participants in an annual health-screening program at the 1972 american dental association session. of 1245 practitioners, 0.9 per cent were positive for hepatitis b surface antigen, and 12.7 per cent were antibody positive. of those who had had clinical hepatitis while studying or practicing dentistry, 43 per cent were seropositive. the frequency of evidence for prior infection with hepatitis b virus increased uniformly ... | 1975 | 1160951 |
| letter: transmission of hepatitis b virus in dermabrasion? | 1975 | 1161918 | |
| prevalence of hepatitis b antigen among army inductees. | eighteen thousand eight hundred and thirty-three consecutive army inductees from the tel aviv and central districts in israel were examined for hepatitis b surface antigen (hbsag) by the counterelectrophoresis technique. the overall prevalence was 1.36%, with a higher rate for males (1.84%) than for females (0.78%). the highest rates were observed among jews of north african and yemenite origin (4.14 and 3.97%, respectively) and the lowest rates was found among jews of european origin (0.31%). t ... | 1975 | 1165174 |
| hepatitis b surface antigen in the serum of infants after deliver from asymptomatic carrier mothers. | a survey of sera of 5,993 pregnant women for hepatitis b surface antigen in tokyo revealed 139 asymptomatic carriers (2.3%), essentially the same as that of a control population of comparable age group (2.2%). none of 59 specimens of cord blood of their newborn infants was positive for hbsag according to an immune adherence hemagglutination assay. in 11 mother-child pairs in whom follow-up was possible for more than seven months, hbsag was detected in the sera of eight infants within the first s ... | 1975 | 1165515 |
| beyond the blood bank. transfusion liability. | 1975 | 1165762 | |
| [chronic hepatitis; practical guidelines for diagnosis and treatment]. | 1975 | 1165797 | |
| letter: control of hepatitis b virus in environmental contamination. | 1975 | 1172855 | |
| letter: control of hepatitis b virus. | 1975 | 1173438 | |
| prevalence of hepatitis b antibody in prostitutes. | the possibility that hepatitis b is transmitted venereally was examined by determining the prevalence of hepatitis b antibody (anti-hb(s)) in populations with different levels of promiscuity. of 258 prostitutes, 31% were anti-hb(s) positive, compared to 10% of 258 female age-matched blood donors, 10% of 48 nuns living in a convent and 15% of 94 nuns working as teachers. prevalence of anti-hb(s) increased with increasing age. in the age group 40-49 years up to 72% of prostitutes were anti-hb(s) p ... | 1975 | 1174290 |
| inhibition of macrophage migration in response to hepatitis bs antigen. | macrophage migration inhibition factor produced in response to purified hepatitis bs antigen has been demonstrated in patients with and recovering from hepatitis b antigen-positive acute viral hepatitis. these results suggest that cell-mediated immunity against this antigen occurs concomitantly with the illness, and may be important in its pathogenesis. in addition, patients with chronic aggressive hepatitis, whether serologically positive or negative for hepatitis bs antigen, were also found to ... | 1975 | 1175889 |
| hepatitis b virus antigens in acute and chronic hepatitis and liver cirrhosis. clinical, morphologic, enzymatic and immunologic analysis. | 1975 | 1177521 | |
| epidemiology of hepatitis b antigen and antibody in hospital patients in copenhagen. | a 4-year continuous screening for hepatitis b antigen (hbag) in all patients admitted to a copenhagen general hospital revealed 253 antigen-positive cases among 99000 patients (2.5%). 97 of the patients had acute or chronic hepatitis, while there were no signs of liver disease in 156. the "healthy" carriers showed a wavy age distribution, indicating an increased transmission of hbag in age groups born 1920-30 and 1940-60. hepatitis b antibody (hbab), measured by a radioimmunoassay, occurred in 8 ... | 1975 | 1179171 |
| [separation of morphological types of hepatitis b-antigen (author's transl)]. | hepatitis b antigen from plasma of a healthy chronic carrier was separated by gel chromatography using 6% agarose gel into fractions with different size (fig. 1). single fractions were further purified by isopycnic centrifugation in cscl (fig. 2) and characterized by electron microscopy (fig. 3). the amount of the different particle groups was determined comparing the extinction peaks in the centrifugates (table 1). 88% of antigen protein was located in the 18 to 25 nm spheres (fig. 3a), 10% in ... | 1975 | 1179880 |
| observations on the core particle of hepatitis b virus and the dna polymerase associated with hepatitis b antigen. | several methods are presented for the purification of core particles of hepatitis b virus (hbv) from nuclei of infected human hepatocytes. no endogenous dna polymerase activity was found in any of the preparations of core particles even when circular double and single stranded dnas were used as exogenous templates. the dna polymerase activity associated with serum hb ag was not stimulated by circular dnas. sodium dodecyl sulfate (sds) at concentrations of greater than or equal to 0.1% inhibited ... | 1975 | 1181929 |
| dna and dna polymerase in the core of the dane particle of hepatitis b. | the core of the dane particle was shown to contain a dna polymerase and a circular double stranded dna with a molecular weight of 1.6 x 10(6) daltons which served as the primer-template for the enzyme. the product of the dna polymerase reaction was in a base paired form and was covalently attached to the circular dna. neither the circular dna nor the attached dna product of the enzyme reaction was attacked by the dnase or released from intact cores until the cores were disrupted with sodium dode ... | 1975 | 1181930 |
| viral hepatitis, type b, in experimental animals. | evidence of natural infection with hepatitis b virus (hbv) in chimpanzees was followed by demonstration that this species provides a highly sensitive animal model system for experimental type b hepatitis. with rare exceptions, inoculation of sero-negative chimps with materials containing infectious hbv produces serologic evidence of infection including appearance of circulating hepatitis b surface antigen (hbs ag) and subsequently development of antibody to hbs ag and hepatitis b core antigen. s ... | 1975 | 1181931 |
| tissue and organ culture studies of hepatitis b virus. | techniques have been developed for the cultivation of human and nonhuman primate liver cells in tissue and organ culture. progressive non-cytocidal involvement of the normal cytoplasmic and nuclear components of cultured liver cells has been demonstrated by specific attachment of fluorescent antibody to hepatitis b core and surface antigens after inoculation of the cultures of human origin with known infective sera and with clinical material. hepatitis b surface antigen may be produced, although ... | 1975 | 1181932 |
| discussion. viral hepatitis: the agents (hepatitis b virus). | 1975 | 1181933 | |
| [entity of the gianotti-crosti's syndrome and its relation to hepatitis b infection]. | 6 cases of acrodermatitis papulosa eruptiva infantum (acrodermatitis papulosa infantilis or gianotti-crostisyndrome: g.c.s.) were observed and the clinical features of this disease are discussed. 1. an erythemato-papular dermatitis mainly of the face, legs, arms, buttocks, not itching, without re-occurrence lasting on the average 20--25 days. 2. an distinct enlargement of the lymph nodes, especially of the inguinal and axillary areas (reactive reticulo-histocytic lymphadenitis). 3. acute hepatit ... | 1975 | 1184390 |
| hepatitis b virus infection in chimpanzees: titration of subtypes. | thirty-four chimpanzees were inoculated with sera containing the adw, ayw, adr, or ayr subtype of hepatitis b surface antigen (hbs ag). twenty-nine of the animals became infected with hepatitis b virus, and in every instance the subtype of hbs ag in the infected animal was the same as the subtype in the inoculum. infectivity titers were established for the adw and ayw inocula. the patterns of serologic events varied in the infected animals but included most of the typical patterns of serologic c ... | 1975 | 1185011 |
| hb-antigen in serum and synovialis in acute hepatitis with and without polyarthritis. | in 27 patients suffering from acute hepatitis serum and synovial-fluid were tested for hb-ag. it was detected in the serum in 19 cases, in the synovial fluid in 2 cases, but never in both serum and synovial-fluid. hb-ag was not found in 6 patients. polyarthritis was seen in 10 cases; 5 of them carried hb-ag in the serum, 2 in the synovial-fluid. a hepatitis b however, was also suspected in the 3 cases with polyarthritis lacking hb-ag. the results suggest that virus b may persist in joints too an ... | 1975 | 1186044 |
| e antigen-antibody system as indicator of liver damage in patients with hepatitis-b antigen. | the clinical relevance of the e antigen-antibody system was investigated in 61 people persistently positive for hepatitis-b surface antigen, including 22 healthy carriers. the e antigen was not detectable in any of the healthy carriers, whereas it was found in 15 out of 28 patients with chronic aggressive hepatitis and two out of 11 with chronic persistent hepatitis. its presence therefore indicates chronic liver disease but its absence does not exclude it. it may prove to be a particularly usef ... | 1975 | 1192012 |
| dane particles, dna polymerase, and e-antigen in two different categories of hepatitis b antigen carriers. | two different categories of hepatitis b antigen carriers have been investigated. one comprises patients treated with dialysis and known to be highly infectious. the other consists of blood donors found in routine screenings. serum specimens have been studied with regard to dane particles. dane-core-associated dna polymerase activity, and e-antigen. the two groups differed markedly in the aspects studied. the five healthy blood donors had no, or very few, detectable dane particles and no detectab ... | 1975 | 1193824 |
| virus infections and kidney disease. | 1975 | 1196274 | |
| infection of neonates and infants with the hepatitis b virus. | 1975 | 1197763 | |
| detection of antibody to hepatitis bs-antigen in patients with acute and chronic hepatitis as measured by a modified procedure of the radioimmunoassay ausria i 125. | a simple modification of the radioimmunoassay ausria i 125 was employed for detecting anti-hbs using the inhibition of a constant amount of hbs ag. anti-hbs was demonstrated in up to 82% of follow-up patients recovering from viral hepatitis b and in 79% of hemophilia patients. the antibody was found in 3.4% of healthy blood donors and in 10% of family contacts of patients with acute hbs ag-positive viral hepatitis. the frequency of anti-hbs in 44 patients with hbs ag-negative chronic aggressive ... | 1975 | 1199021 |
| epidemic hepatitis b: a sustained outbreak in a large military population. | a sustained outbreak of viral hepatitis occurred at an army base in texas between january 1971 and june 1973. seven hundred ninety-two admissions but no deaths were recorded in a military population of 35,000. cases were sporadic, with highest attack rates in low-ranking soldiers with disciplinary problems. twenty-nine per cent of patients had histories of intravenous drug use within six months prior to hospitalization; most of the rest had close personal contact with jaundiced persons. of 505 ... | 1975 | 1202956 |
| hepatitis b core antigen and antibody. | two distinct antigen-antibody systems are associated with the hepatitis b virus: the hepatitis b surface antigen (hbsag, australia antigen) and antibody (anti-hbs) and the recently characterized hepatitis b core antigen (hbcag) and antibody (anti-hbc, anti-core). hbsag is found in the serum of patients acutely or chronically infected with the hepatitis b virus (hbv) and is represented on electron microscopy of such serum as 20 nm spherical and tubular structures and as the surface component of t ... | 1975 | 1204955 |
| purification and characterization of the 'core' particles and their potential diagnostic use. | the basis of the postulated correlation between 'core' particles and 'dane' particles, of their different localization in the hepatocyte and of the different relationships is the mechanism of replication of the infecting material, interesting diagnostic possibilities appear evident in the hepatitis b field. anti-core antibodies would be alone present in the serum of the hepatitic patient, in the acute or convalescent stage, whilst in the serum of the polytransfused patient they would appear in a ... | 1975 | 1204956 |
| core antibodies and other parameters of hepatitis b virus infection in a tropical population. | hbsag (80% of ay subtype) was detected with radioimmunoassay in 10% of a sample of the healthy population in mopti, mali, and in 6% with counterelectrophoresis. anti-hbs was detected in approximately 57% of adults, and anti-hbc in 50%. anti-hbs was not always detectable in anti-hbc positive sera with the methods used, and vice versa. this accounted for up to 85% of an adult group showing anti-hbs, anti-hbc, or both. while anti-hbc percentages climbed more gradually with age, and 'adult' percenta ... | 1975 | 1204958 |
| [culture of hepatitis virus b]. | for the last 25 years, numerous attempts have been made to isolate the hbv agent responsible for hepatitis b by means of cultures 'in vitro'. we have undertaken longterm cultures of children's hepatic tissue (c.h.), conjunctive tissue (human adult h.a.f. and human embryonic fibroblasts h.e.f.) and kb cells; these were put in the presence of 7 sera hb + rich in dane particles. these cells were trypsinized twice a week for almost 3 months and did not present any cytopathogenic effects. electromicr ... | 1975 | 1204959 |
| dna and dna polymerase of a virus-like particle in hepatitis b. | one of the particulate forms bearing hepatitis b antigen in human blood, the 42 nm dane particle, has been shown to contain a small circular-stranded dna with a molecular weight round 1.6 x 10(6) daltons and a dna polymerase. the circular dna functions as a primer-template for the dna polymerase. the circular dna, the dna polymerase and the dna product of the enzyme reaction appear to be internal components of the 28 nm core of the dane particle. dane particle cores labeled with h3 in a dna poly ... | 1975 | 1204960 |
| immunogenetic factors in thalassemia and hepatitis b infection. a multicentre study. | geographical variations in the prevalence of hepatitis b infection were found in association with an increased opportunity of exposure to this virus in patients with homozygous beta-thalassemia in cyprus, greece, sardinia and the united kingdom. no association was found between the gm phenotype of the individuals investigated and susceptibility to hepatitis b virus using hbsag as a marker, or the ability to make antibody to it. variation in the distribution of gm haplotypes does not appear to be ... | 1975 | 1204962 |
| epidemiological distribution and significance of anti-hbs. | hbsag and anti-hbs neutralizing antibodies were quantitatively detected and typed by solid-phase ria procedures in various random populations and in commercial lots of standard immunoglobulins. the prevalence of anti-hbs was considerably higher than prevalence of hbsag, and the specificities of hbsag and anti-hbs overlapped within the single groups of population. the results obtained provided evidence that hepatitis b virus infections are wide-spread, particularly in communities, and that the di ... | 1975 | 1204968 |
| specific immunotherapy proposed for hepatitis b virus infection. | immune response to hepatitis b surface antigen (hbsag), coinciding with removal of hbsag from the circulation, has been shown to be a cell-mediated response assessed by leukocyte migration inhibition assay. immune response to hbsag is a t-cell dependent phenomenon in the nude mouse model. immunological tolerance in man appears to stem from the absence of cellular and humoral immune response to hbsag, causing a chronic carrier state which serves as an epidemiological reservior for the transmissio ... | 1975 | 1204970 |
| viral hepatitis type b: propects for active immunization. | studies conducted in 1970 and 1971 with heat-inactivated ms-2 serum revealed that this active immunizing procedure was associated with a protective effect, a more attenuated hepatitis b infection and a decreased hepatitis b carrier rate. more recent studies have revealed striking differences in the response of unimmunized and immunized persons following a parenteral exposure to the ms-2 strain of hepatitis b virus. serial tests for the detection of hepatitis b surface antigen (hbsag), dna polyme ... | 1975 | 1204971 |
| some considerations regarding active immunization with hbsag. | krugman has demonstrated that injection of heated serum containing hbsag conferred some protection against subsequent challenge with live hepatitis b virus (hbv). it is likely that improved protection will result from injections for larger quantities of hbsag. this can be readily done with purified antigen. we have carried out preliminary studies in mice to investigate the inactivation kinetics of hbsag antigenicity and immunogenicity. rates of inactivation of the two parameters by heat have bee ... | 1975 | 1204972 |
| proceedings: transient lymphocyte-mediated hepatotoxicity in acute viral hepatitis. | 1975 | 1205312 | |
| proceedings: hepatitis b and the new "e" antigen. | 1975 | 1206694 | |
| [intranuclear particles in a patient with chronic aggressive hepatitis treated by immunosuppression]. | after an acute hbsag-positive transfusion hepatitis the patient--a 40 years old women--remained seropositive. later a chronic aggressive hepatitis have developed, which could be evidenced by histological findings. on the electron microphage in the nucleus of liver cells ring-shaped particules 20--25 nm in diameter were revealed. they consisted of granula 2--3 nm in diameter. these particules are considered to represent so called virus-nuclei (core of the virus b of hepatitis) and to play a patho ... | 1975 | 1207692 |
| [non-parenteral infection with hepatitis b virus in families of patients with chronic asymptomatic hb antigenemia. epidemiological and clinical aspects]. | 1975 | 1208213 | |
| [distribution of hepatitis b antigen in cordoba, argentina]. | this article presents the results obtained in the search for the hepatitis b antigen by the counter-immunoelectrophoresis technique in sera of more than 50.000 persons from córdoba, argentina. groups of voluntary blood donors, general population, 20 years old army recruits, patients, with acute hepatitis and patients admitted to a hospital due to other diseases were included in this study. in the apparenly healthy population the positivity of the test ranged between 0.33 to 0.53 percent; the hig ... | 1975 | 1208895 |
| biochemical characterization of australia antigen. evidence for defective particles of hepatitis b virus. | australia antigen exists in the sera of chronic carriers in several particulate forms, one of which may represent the virion of hepatitis b. this report describes the existence of subpopulations of these 43-nm particles, the dane particles, on the basis of the staining properties of their internal cores and banding characteristics in cesium chloride (cscl) density gradients. these data suggested that only a minor proportion of dane particles contained an intact viral genome and represent the sta ... | 1975 | 1211425 |
| [detection of components of the hepatitis b virus (hbv) in hepatocytes]. | in fifty cases of hepatic processes, concominant with serological positivity to the so-called "australian antigen", positivity was demonstrated, by biopsy in 53 per cent of cases and by necropsy in 44 per cent of cases, by way of orceine dyeing according to shikata, and the results were better when due to formaldehyde rather than glutaraldehyde fixation. an electronoptical correlate of hbsag formed microtubular and filamentous structures only partly connected with the smooth endoplasmatic reticu ... | 1975 | 1212707 |
| sources of hepatitis b virus infection in hospital environment. | investigations on the incidence of hepatitis b antigen (hb ag)-carriers among 1466 patients of 11 various hospitals and departments showed that sources of hepatitis infection were more numerous in hospitals for children than in those for adults. the high-risk departments were those of dialysis (5 out of 12 patients), clinical medicine (6.6%), and obstetrics and gynecology, for adults, and those of neuropsychiatry (17.9%) and clinical medicine (11.2%)for children . the highest incidence of hb ag- ... | 1975 | 1216691 |
| [isolation of australia antigen in patients with leprosy]. | 1975 | 1217160 | |
| [frequency of antigen associated to hepatitis due to virus b (hbag) and of antibody (hbac) in healthy subjects and during of course of acute and chronic hepatitis. radioimmunologic study]. | among the several methods employed for the detection of hepatitis b antigen (hbag) and hepatitis b antibody (hbab), radioimmunoassay is considered to be the most sensitive and specific. this paper describes a radioimmunoprecipitation test (rip) for hbag and hbab standardized in our laboratory; it consists of a double-antibody precipitation test in a micro-titer system employing 125i-labeled hbag. the test is compared with double immunodiffusion (id) and with counterimmunoelectrophoresis (cep) in ... | 1975 | 1223946 |
| [radioimmunoquantization of the hbag in clinical liver diseases]. | the two-step direct radioimmune test ria used to detect hepatitis b virus associated antigen (hbsag) appeared to be more sensitive than other immunologic assays. ria demonstrated as hbsag positive 90% of 20 patients with posttransfusion hepatitis; 88% of 50 patients with acute viral hepatitis; 100% of 13 patients with chronic active hepatitis and 35% of 20 patients with cirrhosis; on the other hand with positivity for hbsag in the same patients appeared to be lower by agd, ciep and cf. the quant ... | 1975 | 1223948 |
| [new pathogenetic aspects of hepatitis b in relation to finding hbag inhibitor in the intestinal mucosa and human feces]. | hepatitis b antigen (hbag) positive sera became negative after in vitro incubation with homogenates of human faeces or intestinal mucosa. this was found to occur in all sera tested by various methods. these findings suggest the existence in the human intestine of a substance able to inactivate the hbag and that it is not an antibody or of the nature of interferon. the presence of an inhibitor could explain why b-type hepatitis is seldom if ever faecally transmitted and also the low oral infectio ... | 1975 | 1223951 |
| [geographical differences in the incidence of australia antigen in chronic liver diseases]. | in order to evaluate the role of the australia antigen and of the many other factors commonly invoked in the etiology of chronic liver diseases a series of study have been performed by radioimmunoassay on: a group of blood donors who showed persistent antigenemia and two groups of patients with chronic hepatitis who were studied respectively at brescia general hospital and at the departement of internal medicine of the university of naples. the results were as it follows: 1) liver damage, from m ... | 1975 | 1223953 |
| [qualitative and quantitative radioimmunologic determination of antibodies against hepatitis b surface antigen in hospital personnel]. | 1975 | 1226961 | |
| [hbsag and anti-hbs in chronic, inflammatory liver diseases]. | 1975 | 1226967 | |
| [prevention of serum hepatitis in children]. | 1975 | 1228683 | |
| [application of a reversed passive hemagglutination test to the detection of hbs antigen]. | in this report we present an evaluation of the sensitivity, specificity and ability to detect hbs ag carriers of a new reversed passive hemagglutination test, using immunochemically purified chimpanzee anti hbs bound to stabilized human erythrocytes. the method was shown to have a sensitivity equal (within one two fold dilution) to that of the ausria i 125 ratio immuno assay, and in a double blind comparison detected essentially the same number of hbs ag containing specimens among volunteer bloo ... | 1975 | 1228847 |
| [certain problems of prevention of viral serum hepatitis]. | 1975 | 1230566 |