Publications

humane use of cardiac puncture for non-terminal phlebotomy of wild-caught and released peromyscus spp.	the cardiac puncture technique for obtaining relatively large volume (50-150 µl) blood samples from sedated rodents has been used in research for nearly a century. historically, its use to phlebotomize and then release live rodents was more common. however, recently its use in a non-terminal capacity frequently imparts negative connotations in part because exsanguination of sedated animals via cardiac puncture is now an american veterinary medical association-approved euthanasia technique. this ...	2020	32397470
coordinated changes across the o2 transport pathway underlie adaptive increases in thermogenic capacity in high-altitude deer mice.	animals native to the hypoxic and cold environment at high altitude provide an excellent opportunity to elucidate the integrative mechanisms underlying the adaptive evolution and plasticity of complex traits. the capacity for aerobic thermogenesis can be a critical determinant of survival for small mammals at high altitude, but the physiological mechanisms underlying the evolution of this performance trait remain unresolved. we examined this issue by comparing high-altitude deer mice (peromyscus ...	2020	32429808
penicillium diversity in canadian bat caves, including a new species, p. speluncae.	penicillium species were commonly isolated during a fungal survey of bat hibernacula in new brunswick and quebec, canada. strains were isolated from arthropods, bats, rodents (i.e. the deer mouse peromyscus maniculatus), their dung, and cave walls. hundreds of fungal strains were recovered, of which penicillium represented a major component of the community. penicillium strains were grouped by colony characters on blakeslee's malt extract agar. dna sequencing of the secondary identification mark ...	2020	32467912
body size trends in response to climate and urbanization in the widespread north american deer mouse, peromyscus maniculatus.	body size decline is hypothesized to be a key response to climate warming, including warming driven by urban heat islands. however, urbanization may also generate selective gradients for body size increases in smaller endotherms via habitat fragmentation. here we utilize a densely sampled, multi-source dataset to examine how climate and urbanization affect body size of peromyscus maniculatus (pema), an abundant rodent found across north america. we predicted pema would conform to bergmann's rule ...	2020	32483167
large nest building and high marble-burying: two compulsive-like phenotypes expressed by deer mice (peromyscus maniculatus bairdii) and their unique response to serotoninergic and dopamine modulating intervention.	this study aimed to further dissect the deer mouse (peromyscus maniculatus bairdii) model of compulsive-like behavior with respect to two persistent-like behavioral phenotypes viz. large nest building (lnb) and high marble-burying (hmb), which may be relevant to understanding the neurobiology of different symptom dimensions in obsessive-compulsive and related disorders. since lnb is sensitive to chronic, high dose escitalopram intervention but hmb is not, we assessed whether the two behaviors co ...	2020	32619566
assessment of the stress response in north american deermice: laboratory and field validation of two enzyme immunoassays for fecal corticosterone metabolites.	stress physiology is commonly employed in studies of wildlife ecology and conservation. accordingly, we need robust and suitable methods to measure stress physiology in the field. fecal cortisol/corticosterone metabolites (fcms) are now increasingly being used to non-invasively evaluate adrenocortical activity; a measure of stress physiology. however, immunoassays that measure fcms must be appropriately validated prior to their use and factors that can influence fcms, such as trap-induced stress ...	2020	32630075
parasite species co-occurrence patterns on peromyscus: joint species distribution modelling.	hosts are often infested by multiple parasite species, but it is often unclear whether patterns of parasite co-occurrence are driven by parasite habitat requirements or parasite species interactions. using data on infestation patterns of ectoparasitic arthropods (fleas, trombiculid mites, cuterebrid botflies) from deer mice (peromyscus maniculatus), we analyzed species associations using joint species distribution modelling. we also experimentally removed a flea (orchopeas leucopus) from a subse ...	2020	32637312
molecular detection of leptospira interrogans and borrelia burgdorferi in wild rodents from mexico.	leptospirosis and lyme borreliosis are zoonotic emerging diseases of global importance and wide distribution. the aim of this study was to detect by molecular testing to leptospira interrogans and borrelia burgdorferi sensu lato in wild rodents from nuevo leon, quintana roo, and campeche, mexico. this study is the first in report to chaetodipus nelsoni, dipodomys merriami, and peromyscus eremicus infected with l. interrogans in mexico. besides, chaetodipus hispidus, heteromys gaumeri, heteromys ...	2020	32639187
oral vaccination with recombinant vesicular stomatitis virus expressing sin nombre virus glycoprotein prevents sin nombre virus transmission in deer mice.	sin nombre virus (snv) is the major cause of hantavirus cardiopulmonary syndrome (hcps) in north america, a severe respiratory disease with a high fatality rate. snv is carried by peromyscus maniculatus, or deer mice, and human infection occurs following inhalation of aerosolized virus in mouse excreta or secreta, often in peri-domestic settings. currently there are no fda approved vaccines or therapeutics for snv or any other hantaviruses, therefore prevention of infection is an important means ...	2020	32733817
sars-cov-2 infection, neuropathogenesis and transmission among deer mice: implications for reverse zoonosis to new world rodents.	coronavirus disease-19 (covid-19) emerged in november, 2019 in china and rapidly became pandemic. as with other coronaviruses, a preponderance of evidence suggests the virus originated in horseshoe bats (rhinolophus spp.) and likely underwent a recombination event in an intermediate host prior to entry into human populations. a significant concern is that sars-cov-2 could become established in secondary reservoir hosts outside of asia. to assess this potential, we challenged deer mice (peromyscu ...	2020	32793912
variation in space and time: a long-term examination of density-dependent dispersal in a woodland rodent.	dispersal is a fundamental ecological process that can be affected by population density, yet studies report contrasting effects of density on propensity to disperse. in addition, the relationship between dispersal and density is seldom examined using densities measured at different spatial scales or over extensive time series. we used 51 years of trapping data to examine how dispersal by wild deer mice (peromyscus maniculatus) was affected by changes in both local and regional population densit ...	2020	32809054
long-term and interactive effects of different mammalian consumers on growth, survival, and recruitment of dominant tree species.	throughout the world, numerous tree species are reported to be in decline, either due to increased mortality of established trees or reduced recruitment. the situation appears especially acute for oaks, which are dominant features of many landscapes in the northern hemisphere. although numerous factors have been hypothesized to explain reductions in tree performance, vertebrate herbivores and granivores may serve as important drivers of these changes. here, using data from 8- and 14-year-old exc ...	2020	32884658
chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes.	small mammals native to high altitude must sustain high rates of thermogenesis to cope with cold. skeletal muscle is a key site of shivering and non-shivering thermogenesis, but the importance of mitochondrial plasticity in cold hypoxic environments remains unresolved. we examined high-altitude deer mice, which have evolved a high capacity for aerobic thermogenesis, to determine the mechanisms of mitochondrial plasticity during chronic exposure to cold and hypoxia, alone and in combination. cold ...	2020	32886797
corticosterone response by peromyscus mice to parasites, reproductive season, and age.	a common response to parasite infestations is increased production of glucocorticoid hormones that regulate immune function. we examined relationships between ectoparasite infestations and fecal corticosterone metabolites (fcm) in deer mice (peromyscus maniculatus). furthermore, we experimentally removed fleas to determine if reductions in ectoparasites affected fcm production. individuals were assigned to control (no flea removal) or treatment (anti-flea application, physical combing) groups an ...	2020	33017585
practical guide to trapping peromyscus leucopus (rodentia: cricetidae) and peromyscus maniculatus for vector and vector-borne pathogen surveillance and ecology.	arthropods pests are most frequently associated with both plants and vertebrate animals. ticks, in particular the blacklegged ticks ixodes scapularis say and ixodes pacificus cooley & kohls (acari: ixodidae), are associated with wildlife hosts and are the primary vectors of lyme disease, the most frequently reported vector-borne disease in the united states. immature blacklegged ticks in the eastern united states frequently use small mammals from the genus peromyscus as hosts. these mice are com ...	2020	33135755
intersecting paths of emerging and reemerging infectious diseases.	severe acute respiratory syndrome coronavirus 2 (sars-cov-2) shares common clinicopathologic features with other severe pulmonary illnesses. hantavirus pulmonary syndrome was diagnosed in 2 patients in arizona, usa, suspected of dying from infection with sars-cov-2. differential diagnoses and possible co-infections should be considered for cases of respiratory distress during the sars-cov-2 pandemic.	2021	33704045
sars-cov-2 infection, neuropathogenesis and transmission among deer mice: implications for spillback to new world rodents.	coronavirus disease-19 (covid-19) emerged in late 2019 in china and rapidly became pandemic. as with other coronaviruses, a preponderance of evidence suggests the virus originated in horseshoe bats (rhinolophus spp.) and may have infected an intermediate host prior to spillover into humans. a significant concern is that sars-cov-2 could become established in secondary reservoir hosts outside of asia. to assess this potential, we challenged deer mice (peromyscus maniculatus) with sars-cov-2 and f ...	2021	34010360
continuing orthohantavirus circulation in deer mice in western montana.	hantavirus pulmonary syndrome (hps) is an often-fatal disease caused by new world hantaviruses, such as sin nombre orthohantavirus (snv). in the us, >800 cases of hps have been confirmed since it was first discovered in 1993, of which 43 were reported from the state of montana. the primary cause of hps in the us is snv, which is primarily found in the reservoir host peromyscus maniculatus (deer mouse). the reservoir host covers most of the us, including montana, where multiple studies found snv ...	2021	34072112