Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the development of a "high volume tissue schizonticidal drug screen" based upon mortality of mice inoculated with sporozoites of plasmodium berghei. | a biological test system has been developed to assess the prophylactic activity of compounds against sporozoite-induced plasmodium berghei malaria in mice. the procedure was designed to serve as the foundation of an effort to develop tissue schizonticidal drugs in a manner parallel to that of a previous system employed in the u.s. arym antimalarial drug development program to screen compounds for blood schizonticidal activity. in tests with 35 known antimalarial compounds, the new screen was fou ... | 1979 | 116556 |
| plasmodium fragile and macaca mulatta monkeys as a model system for the study of malaria vaccines. | pladmodium fragile and the macaca mulatta monkey are presented as a model system for the study of malarial vaccines. four animals were immunized with culture-grown p. fragile merozoites and subsequently challenged with culture-produced parasites. one animal failed to develop a detectable parasitemia following primary challenge. two other immunized animals had primary infections which were short-term. the parasitemias in these three monkeys following secondary challenge were short-term and the im ... | 1979 | 116557 |
| immunogenetic studies of rhesus monkeys. 6. absence of the human xga blood group on rhesus erythrocytes. | it was not possible to demonstrate xga on the erythrocytes of any of 140 rhesus monkeys of both sexes tested with human antiserum rendered specific for xga by absorption. | 1979 | 116572 |
| effects of intravenous injection of leukocytic endogenous mediator on cardiohepatic functions in rhesus macaques. | a crude preparation of leukocytic endogenous mediator administered iv over a 10-minute period into a rhesus macaque at a dosage of 10 ml/kg of body weight resulted in hypotension, tachycardia, vasodilation, hypoalbuminemia, and hypoproteinemia. decreases in cardiac and hepatic functions and biphasic changes in peripheral polymorphonuclear leukocytes also were seen. all measured changes, except hepatic functions and plasma albumin values, returned to base-line values within 24 hours. data indicat ... | 1979 | 116575 |
| opsonization, phagocytosis and killing of streptococcus mutans by polymorphonuclear leukocytes, in relation to dental caries in the rhesus monkey (macaca mulatta). | 1979 | 116635 | |
| 360 degrees prophylactic cryoretinopexy. a clinical and experimental study. | complications occurred after 360 degrees prophylactic cryoretinopexy in three of six eyes in which fellow eyes had previously developed aphakic retinal detachment. two of the six prophylactically treated eyes developed retinal detachment in advance of anticipated cataract surgery, and a third developed vitreitis and progressive preretinal membrane formation after uncomplicated cataract extraction. in an experiment study with rhesus monkeys, preretinal membrane formation was produced by administe ... | 1979 | 116636 |
| a direct inferior parietal lobule projection to the presubiculum in the rhesus monkey. | 1979 | 116714 | |
| paired stimulation of the frontal eye fields and the euperior colliculus of the rhesus monkey. | 1979 | 116715 | |
| laminar origins and terminations of cortical connections of the occipital lobe in the rhesus monkey. | cortical connections within the occipital lobe (areas 17, 18 and 19) of the rhesus monkey are investigated with the autoradiographic and horseradish peroxidase procedures. two efferent systems, each with a specific laminar organization, are observed. (1) rostrally directed connections, from area 17 to 18, area 18 to 19 and area 19 to the inferotemporal region (area te), originate from neurons in layer iiic (and, in area 19, from a small complement of neurons in layer va), and terminate in and ar ... | 1979 | 116716 |
| taurolithocholic acid and chlorpromazine cholestasis in the rhesus monkey. | 1979 | 116762 | |
| treatment of rhesus monkeys (macaca mulatta) with intravaginal rings impregnated with either progesterone or norethisterone. | the effects of both progesterone- and norethisterone-loaded intravaginal rings were investigated in twenty-five rhesus monkeys for 52 weeks. the intravaginal rings were designed to provide a sustained release of either the human dosage level of the hormone or ten times this level. untreated placebo rings were used for control purposes. the devices were well retained. with the exception of increased plasma fibrinogen levels in animals treated with norethisterone, no marked differences in either l ... | 1979 | 116799 |
| the influence of vagotomy on bile kinetics in the rhesus monkey. | an increased incidence of gallstones has been reported following truncal vagotomy and gastric drainage but never conclusively proven. in the rhesus monkey, bile composition and flow is similar to man. a model of biliary drainage was established which permits continuous monitoring of bile kinetics. following truncal vagotomy and pyloroplasty, a significant fall in the bile acid concentration was observed, accompanied by a rise in cholesterol concentration. this resulted in an overall rise in chol ... | 1979 | 116853 |
| immunofluorescent and immunoelectron microscopic demonstration of primate heart muscle antigens cross-reactive with streptococcus pyogenes. | the presence of antigens in heart muscles cross-reactive with antibodies against streptococcus pyogenes were examined in heart samples of seven primate species (chimpanzee, rhesus macaque, stump-tailed macaque, hamadryas baboon, capuchin monkey, green monkey and patas monkey). cross-reactive antigens were localized by means of the indirect immunofluorescent technique in nearly all samples tested. the fluorescence pattern was the same as found in the heart muscle of other mammals. using the indir ... | 1979 | 116866 |
| atherosclerotic plaque regression in rhesus monkeys induced by bile acid sequestrant. | 1979 | 116868 | |
| in vitro metabolism of tetrahydrocannabinol by rhesus monkey liver and human liver. | 1978 | 116879 | |
| reproduction in rhesus monkeys chronically exposed to delta-9-tetrahydrocannabinol. | 1978 | 116881 | |
| social behavior of rhesus monkeys chronically exposed to moderate amounts of delta-9-tetrahydrocannabinol. | 1978 | 116882 | |
| chronic hyperinsulinemia in the fetal rhesus monkey: effects on fetal growth and composition. | 1979 | 116897 | |
| fetal sex ratio in the rhesus (macaca mulatta). | fetal sex ratio was determined in several hundred timed macaca mulatta pregnancies terminated by hysterotomy between 75 and 179 days' gestation. from 75 to 149 days' gestation a greater number of females occurred in utero, while after 150 days a greater number of males was observed. however, this difference was not statistically significant. | 1979 | 116948 |
| rhesus monkey aqueous humor composition and a primate ocular perfusate. | the composition of rhesus monkey aqueous humor has been studied in large-volume, pooled samples. replicate determinations of the concentrations of a number of constituents have been carried out for both aqueous humor and serum from large veins by means of automatic analyzing equipment. since aqueous humor has been obtained by anterior chamber paracentesis, it is a mixture of anterior and posterior chamber aqueous. when compared to serum, the pooled aqueous contains an excess of chloride, bicarb ... | 1979 | 116968 |
| porous titanium endosseous dental implants in rhesus monkeys: microradiography and histological evaluation. | artificial tooth roots with porous surface coatings were fabricated by sintering spherical powder of titanium alloy to solid cylindrical cores. the tooth roots were implanted subgingivally in healed mandibular premolar extraction sites of fifteen rhesus monkeys. supracrestal abutments were screwed into pretapped holes in the superior aspect of the primary subgingival stage four to eight weeks after implantation of the root. clinical evaluations were performed monthly. ten animals were sacrificed ... | 1979 | 117007 |
| in vivo enhancement of dengue virus infection in rhesus monkeys by passively transferred antibody. | five pairs of juvenile, dengue virus-susceptible rhesus monkeys were given normal or dengue-immune human cord-blood serum injected intravenously to a final dilution of 1:300. the pool of immune human cord-blood serum had a titer of antibody to dengue type 2 virus (d2v) of 1:140 in the plaque-reduction neutralization test and a titer of human monocyte infection enhancement of greater than 1:2,000,000. fifteen minutes after inoculation of serum, animals were infected with d2v (strain no. 16681). d ... | 1979 | 117061 |
| induction of allergic encephalomyelitis in rhesus monkeys treated with anti monkey thymocyte sera. | treatment with rabbit anti-moneky thymus cell sera whether limited (3 days) or extensive (15 days), did not alter the development of experimental allergic encephalomyelitis (eae) in rhesus monkeys challenged with myelin basic protein or central nervous system tissue (cns) when compared to similarly challenged control monkeys treated with normal rabbit serum. no consistent difference in disease incidence or intensity as measured by incubation period, neurologic signs or cns pathology was observed ... | 1979 | 117083 |
| infection and transmission studies with plasmodium simiovale in the macaca mulatta monkey. | six different anophelines--anopheles freeborni, an. b. balabacensis, an. maculatus, an. stephensi, an. atroparvus, and an. quadrimaculatus--were shown to be susceptible to infection with plasmodium simiovale when fed upon splenectomized macaca mulatta monkeys between the 1st and 26th days of patent parasitemia. transmission was obtained via the bites of an. b. balabacensis and an. maculatus mosquitoes. prepatent periods in m. mulatta monkeys following sporozoite inoculation ranged from 11 to 20 ... | 1979 | 117087 |
| kinetics of drug-drug interactions: biliary excretion of iodoxamic acid and iopanoic acid in rhesus monkeys. | the dynamic method originally developed for studying the capacity-limited kinetics of the cholecystographic agents iodoxamic acid and iopanoic acid was applied to study the in vivo interactions of these two compounds following coadminstration in the monkey. results indicate that these interactions are complex. the compounds appear to compete for plasma protein binding sites as well as for binding sites on intrahepatic proteins. the biliary excretion data apparently fit the "ligand exclusion" mod ... | 1979 | 117095 |
| primaquine analogues: derivatives of 4-amino-2-methoxyacridine. | based on the antimalarial activity of primaquine (1a) and its 4-methyl analogue 1b, 4-aminoacridinyl analogues, 4-[(4-amino-1-methylbutyl)amino]-2-methoxyacridine (2a) and 4-[(4-amino-1-methylbutyl)amino]-2-methoxy-9-methylacridine (2b), were prepared and evaluated as potential tissue schizonticidal agents. these compounds were found to be substantially less active than primaquine against plasmodium cynomolgi in the rhesus monkey. the antileishmanial activity in hamsters of 4-[[6-(diethylamino)h ... | 1979 | 117105 |
| a spontaneous outbreak of polychlorinated biphenyl (pcb) toxicity in rhesus monkeys (macaca mulatta): clinical observations. | a spontaneous, progressive disease occurred in a large domestic breeding colony of rhesus monkeys (macaca mulatta). the disease was characterized by slow but continuous weight loss, alopecia, acne, facial edema, diarrhea and trauma from other monkeys. breeding efficiency was impaired with a high incidence of abortions and stillbirths. live offspring were small and unthrifty contributing to a high infant mortality rate. the cause of this disease was polychlorinated biphenyls (pcss) which were pre ... | 1979 | 117226 |
| a spontaneous outbreak of polycholorinated biphenyl (pcb) toxicity in rhesus monkeys (macaca mulatta): toxicopathology. | polychlorinated biphenyls (pcbs) were shown to be the cause of a wasting syndrome and reproductive dysfunction in a group of rhesus monkeys (macaca mulatta). the polychlorinated biphenyls were found by gas chromatographic analysis in high amounts in the superficial layers of concrete slab floors in the housing facility. the concrete sealant was suspected as the original source although it is not known whether it contained polychlorinated biphenyls before it was applied or if it was contaminated ... | 1979 | 117227 |
| 17 beta-hydroxysteroid dehydrogenase activity in the pituitary gland and neural tissue of rhesus monkeys. | 1979 | 117263 | |
| face recognition in the rhesus monkey. | 1979 | 117394 | |
| a comparative study of the dosimetry of bone-seeking radionuclides in man, rhesus monkey, beagle, and miniature pig. | 1979 | 117510 | |
| effects of influenza, mumps, and western equine encephalitis viruses on fetal rhesus monkeys (macaca mulatta). | pregnant rhesus monkeys were infected via instillation of influenza, mumps and western equine encephalomyelitis viruses respectively into the amniotic sacs at approximately 90 days gestation to determine if fetal infections would occur. virus was recovered from fetal tissues after seven days in 100% of the exposed animals. thus, the viruses are capable of causing fetal infection. rhesus monkey fetuses were inoculated with influenza, mumps and wee viruses by the direct intracerebral route at appr ... | 1979 | 117564 |
| fetal mortality and malformations associated with experimental infections of western equine encephalomyelitis vaccine virus in rhesus monkeys (macaca mulatta). | pregnant rhesus monkeys were infected via installation of western equine encephalomyelitis (wee) vaccine virus into the amniotic sacs at 50 and 80 days gestation to determine if the resulting infections would produce fetal mortality or fetal malformations, particularly within the central nervous system. of those receiving virus at 50 days gestation, 13 of 18 fetuses were aborted or dead in utero at time of caesarean section; 2 of 18 were malformed (hydrocephalus and polyarthrosis); and 3 of 18 w ... | 1979 | 117565 |
| testicular steroidogenesis in the rhesus monkey (macaca mulatta. | studies were undertaken to investigate testicular steroidogenesis in the rhesus monkey macaca mulatta. testicular fragments (50 mg) were incubated for 3 hr with pregnenolone-7-3h or with progesterone-7-3h. the major metabolite of pregnenolone was progesterone (70.1%), with a lesser conversion to 17-hydroxyprogesterone (1.6%), androstenedione (3.3%), and testosterone (7.2%). the delta-5 intermediates 17-hydroxypregnenolone (4.6%) and dehydroepiandrosterone (8.6%) were also identified in the pregn ... | 1979 | 117575 |
| kallikrein inhibitor (aprotinin): plasma turnover and effects on coagulation in rhesus monkeys. | 1979 | 117681 | |
| thyroid calcitonin cells and parathyroid gland of the indian rhesus monkey macaca mulatta in response to experimental hypercalcaemia. | rhesus monkey (macaca mulatta) were subjected to hypercalcaemia by daily intramuscular injections of vitamin d2 (100,000 iu) and by providing them gram soaked in 1% cacl2 solution for eating and 1% cacl2 solution (prepared in tap water) for drinking. after 10, 15, 20 and 30 days of such treatment the serum calcium level recorded a rise (18.24 +/- 0.56, 26.20 +/- 1.30, 17.25 +/- 0.25 and 20.50 +/- 0.55 mg/dl respectively) as compared to those of control animals (12.80 +/- 1.00, 12.30 +/- 0.50, 12 ... | 1979 | 117736 |
| antimalarial properties of floxacrine, a dihydroacridinedione derivative. | evaluations of the activities of floxacrine [7-chloro-10-hydroxy-3-(4-trifluoromethylphenyl)-3,4-dihydroacridine-1,9(2h, 10h)-dione] in owl monkeys infected with trophozoites of a chloroquine-quinine-resistant strain of plasmodium falciparum, a strain of this plasmodium resistant to both of these quinolines and pyrimethamine, or a strain of p. vivax resistant only to pyrimethamine showed that: (i) this compound regularly effected temporary clearance of parasitemia at daily doses of 1.25 to 2.5 m ... | 1979 | 117747 |
| proceptive patterns of behavior throughout the menstrual cycle in female rhesus monkeys. | 1979 | 117790 | |
| the fate of lysergic acid di[14c]ethylamide ([14c]lsd) in the rat, guinea pig and rhesus monkey and of [14c]iso-lsd in rat. | 1979 | 117811 | |
| a stereo-radiographic and histologic study of coronary arteries in normal adult rhesus monkeys. | 1979 | 118115 | |
| airway responses to histamine and methacholine in ascaris suum-allergic rhesus monkeys. | 1979 | 118144 | |
| retrobulbar abscess in an infant rhesus monkey. | 1979 | 118149 | |
| pure tone thresholds for the rhesus monkey. | auditory thresholds were measured for 18 ears from 13 rhesus monkeys using a simple reaction-time procedure. the threshold contour was a smooth w-shaped function with rises at the extreme frequencies and around 4 khz and was comparable in shape with previously reported thresholds for this animal. standard deviations averaged 5.3 db. | 1978 | 118150 |
| annual rhythms of luteinizing hormone, follicle-stimulating hormone, prolactin and testosterone in the serum of male rhesus monkeys. | six male rhesus monkeys were kept under rigidly controlled conditions for 1-2 years. during august of the first year a thyrotrophin releasing hormone (trh) test was performed on each of the monkeys by giving 10 microgram trh as a bolus injection. significantly increased serum prolactin levels occurred 15 min after the injection. after a training period of 2 months, during which blood samples were collected every other day by puncture of the saphenous vein, blood was collected three times a week ... | 1979 | 118229 |
| characterization of infection and replication of mason-pfizer monkey virus in human cell cultures. | human cells derived from both normal and neoplastic tissues can be infected by mason-pfizer monkey virus (mpmv) without accompanying cytopathology. infection of cell cultures such as human rhabdomyosarcoma (a204) results in a persistenly infected cell line which can be subcultured over 30 sequential culture passages without significant change in phenotype properties according to reverse, transcriptase (rt), mpmv p27 antigen content, virus particle count and infectivity titre. productive virus in ... | 1979 | 118235 |
| synthesis of 4-alkyl and 4-(beta-alkylvinyl) derivatives of primaquine as potential antimalarials. | 4(beta-alkylvinyl)-6-methoxy-8-nitroquinolines (6) were prepared from 6-methoxy-8-nitroquinoline-4-carboxaldehyde (5) via a wittig reaction. stannous chloride reduction of 6 gave 4-(beta-alkylvinyl)-8-amino-6-methoxyquinolines (8), whereas catalytic reduction of 6 using raney nickel catalyst gave 4-alkyl-8-amino-6-methoxyquinolines (7). alkylation of 7 and 8 with 4-iodo-1-phthalimidopentane, followed by removal of the phthaloyl-protecting group with hydrazine, gave 4-alkyl and 4-(beta-alkylvinyl ... | 1979 | 118257 |
| a practicable immunological approach to block spermatogenesis without loss of androgens. | the intrinsic capacity of the immune system to elicit immune response selectively against late developing sperm proteins has been mobilized to intercept spermatogenesis. bacillus calmette-guérin given in appropriate doses intratesticularly is effective in bringing about this effect. in dogs and rhesus monkeys, the sperm count in the semen declined precipitously, and almost complete azospermia was attained in 4-6 weeks after immunization. the few sperm cells that were present were immotile. exami ... | 1979 | 118455 |
| cholecystokinin suppresses sham feeding in the rhesus monkey. | the satiety effect of slow intravenous infusions of impure cholecystokinin (cck) was investigated in 5 rhesus monkeys during sham feeding. cck suppressed sham feeding. the dose for 50% inhibition of sham feeding was about 10 u/kg-hr; 20 u/kg-hr abolished sham feeding. no dose produced retching, vomiting, diarrhea or other behavioral signs of toxicity. these results demonstrate the potency of cck for inhibiting feeding in the monkey when gastric, intestinal and postabsorptive mechanisms are not a ... | 1979 | 118472 |
| serum fsh, lh and testosterone in the male rhesus following prostaglandin injection. | adult male rhesus were treated with pge2, pgf2 alpha or the 13,14-dihydro-15-keto metabolite of pge2 in a randomized crossover design. serum concentrations of fsh, lh and testosterone were determined and compared to the respective values in the same uninjected animals. no significant changes were noted in controls or following the metabolite injection. fsh increased gradually for 4 hours after metabolite treatment. in contrast, injection of pgf2 alpha was followed by an abrupt (within 15 minutes ... | 1979 | 118486 |
| comparison of coronary with aortic fatty streaks in rhesus monkeys. | 1979 | 118522 | |
| the dosing schedule dependent toxicities of adriamycin in beagle dogs and rhesus monkeys. | the toxic effects of adriamycin were studied following i.v. administration of from 10.0 mg/kg to 0.039 mg/kg (200--0.780 mg/m2) to beagle dogs, and from 5.83 mg/kg to 0.625 mg/kg (49.9--7.5 mg/m2) in rhesus monkeys by a variety of short and long term treatment schedules. 5 daily doses and 1 dose every 3 weeks were given for both species and, only in dogs, as single injections, 10 daily treatments and 5 daily doses followed by 9 days rest, repeated 3 times. in both species, short term administrat ... | 1979 | 118548 |
| massive doses of steroids in cryogenic cerebral injury and edema. | cryogenic lesions were produced in the brains of rhesus monkeys and the accompanying edema measured by quantitative chemical methods. no effect on this type of edema could be demonstrated in animals treated with massive doses of steroids. | 1979 | 118553 |
| comparative studies on the pre- and postterminal blood vessels in the cerebellar cortex of rhesus monkey, cat, and rat. | in the rhesus monkey, cat and rat, pial arteries give off branches which run vertically through all three layers of the cerebellar cortex. the large cortical arteries are surrounded by a perivascular space in the molecular layer. their wall consists of several layers of smooth-muscle cells and the luminal endothelium. as the arteries reach the deeper layers of the cerebellar cortex, the number of smooth-muscle cells is reduced. in the rat, sometimes no smooth-muscle cells are detectable in the p ... | 1979 | 118682 |
| branches of the aortic arch in the cynomolgus macaque (macaca fascicularis). | the aortic arch branching patterns of 49 male macaques (macaca fascicularis) were described and classified according to the classification systems of degaris, and the incidence of each pattern was determined. the most frequent pattern observed was a two-branch type in which a truncus communis of intermediate length (7 to 11 mm) and the left subclavian artery constituted the only aortic arch branches. five patterns not previously described in the cynomolgus were observed. comparison of the cynomo ... | 1979 | 118690 |
| effects of increased testosterone secretion on the behavior of adult male rhesus living in a social group. | selected members of an all-male social group of rhesus monkeys were treated with twice-weekly injections of human chorionic gonadotropin (hcg) to determine the effects of the consequently increased androgen secretion on social behavior. radioimmunoassay of blood samples confirmed significant increases in serum testosterone levels in each of 4 subject, but only 3 of these showed significant behavioral changes. the basic social structure of the group, including the dominance hierarchy, was not dis ... | 1979 | 118907 |
| backward and forward masking in macaca mulatta. | 8 highly trained rhesus monkeys were examined on both backward and forward masking to determine the feasility of studying masking in unrestrained monkeys and of studying perceptual phenomenon without the confounding of linguistic variables. it was found that monkeys could respond well under the given conditions. the data indicated a more pronounced effect of the masking stimulus on backward masking than on forward masking. | 1979 | 118909 |
| establishing and maintaining clinically healthy gingivae in rhesus monkeys. | the aim of the present investigation was to determine a method and a minimal frequency of plaque removal for the establishment and maintenance of clinically healthy gingivae in rhesus monkeys. six adult, male monkeys were used and divided into three groups. in each group different methods were used for plaque removal. frequencies of plaque removal of one, two and three times per week for consecutive weeks were tested. the results showed that gingival health could be established and maintained wi ... | 1979 | 118986 |
| acquisition of prerequisites to conservation by macaques. | through a progressive series of learning sets, two rhesus macaques were trained to discriminate transformations that produce change of substance from other transformations and manipulations. several tests were administered to assess the generalization of this discrimination to a variety of objects and shapes and to assess the effects, if any, of size cues, experimenter familiarity, and various methods to problem presentation. after training was completed, performance was not greatly affected by ... | 1979 | 119026 |
| amniocentesis and antenatal sex determination in the rhesus monkey (macaca mulatta). | antenatal sex was correctly identified in 87.5% of the rhesus monkeys studied by evaluation of sex chromatin bodies in the exfoliated cells present in amniotic fluid. fluid samples were obtained by either amniocentesis, amnioscopy, or by cesarean section at 80--120 days of gestation. amniotic fluid concentrations of progesterone, total estrogen, and testosterone were correlated with fetal sex. concentrations of these hormones decreased over the time period examined. amniocentesis is a simple pro ... | 1979 | 119051 |
| menetrier's disease in a rhesus monkey (macaca mulatta). | gross and microscopic features closely resembling those found in menetrier's disease in man are described in a 20-month-old rhesus monkey. the gastric lining was characterized by greatly enlarged rugae caused by mucosal hypertrophy and hyperplasia along with outfolding of the muscularis mucosa and the submucosa. the mucosa and submucosa were infiltrated with inflammatory cells, mainly lymphocytes and plasma cells. | 1979 | 119052 |
| persistence of impaired reversal learning in young monkeys exposed to low levels of dietary lead. | lead acetate in milk was fed daily to infant rhesus monkeys at doses averaging 0 (control), 0.287 (low-pb), or 0.880 (high-pb) mg/kgd for the first year of life. pb concentrations in whole blood (pbb) averaged 4.15, 31.71, and 65.17 microgram/dl for the control, low-pb, and high-pb groups, respectively, during the year of treatment and declined toward control levels when pb dosing was stopped. behavioral observations during the year of treatment had shown that both experimental groups were retar ... | 1979 | 119054 |
| anaesthetic effects of various ratios of ketamine and xylazine in rhesus monkeys (macacca mulatta). | intramuscular injection of selected ratios of ketamine and xylazine provided smooth anaesthetic induction, a wide safety margin, and no significant undersirable side effects. induction and recovery times, duration of anaesthesia, and thermoregulatory ability can be affected by different combinations of ketamine and xylazine. the addition of xylazine to ketamine increases muscle relaxation, recovery time, and duration of anaesthesia, while generally decreasing induction time and thermoregulatory ... | 1979 | 119109 |
| flexible fiberoptic bronchoscopy of the rhesus monkey (macaca mulatta). | using a flexible fiberoptic bronchoscope, 10 rhesus monkeys were bronchoscoped 30 times without complication. the bronchoscopic anatomy was found to be similar to that of the human except for the presence of a right cardiac lobe in the monkey. | 1979 | 119111 |
| a survey for anatrichosoma (nematoda: trichinellida) in wild-caught macaca mulatta. | one hundred rhesus monkeys which were captured from two geographical sites were tested for anatrichosoma, a nematode that lives in the nasal passages. the monkeys were tested using both fecal examinations and nasal swabs. three percent of the monkeys from one site were positive, and 68% from the other site were positive. twenty-one percent of the animals tested by fecal examination were positive and 48% were positive using nasal swab examination. | 1979 | 119112 |
| chylothorax in rhesus monkeys with intravenous catheters. | chylothorax associated with the use of indwelling intravenous catheters was diagnosed in 13 macaca mulatta. clinical signs were marked respiratory embarrassment or sudden death. lesions at necropsy included large quantities of sterile pleural fluid, pulmonary atelectasis and chronic fibrinous pleuritis. lipid was present in the effusion and in tissue sections of visceral pleura. | 1979 | 119113 |
| effects of satiety on self-stimulation of the orbitofrontal cortex in the rhesus monkey. | self-stimulation of the orbitofrontal cortex of the rhesus monkey was found to be attenuated after the monkeys were fed to satiety. self-stimulation at some other sites (e.g. the nucleus accumbens septi, the region of the substantia nigra, and the caudate nucleus) was relatively unaffected in the same test sessions by the satiety. in recordings from single neurons in the monkey orbitofrontal cortex, neurons of the type found in the lateral hypothalamus with sustained responses associated with th ... | 1979 | 119182 |
| the crossed cortico-caudate projection in the rhesus monkey. | in the normal young adult rhesus monkey, reduced silver staining of degenerating axons revealed that the lateral prefrontal cortex projects to the caudate nucleus of the contralateral hemisphere. this crossed prefronto-caudate projection provides a means whereby the prefrontal cortex can affect the neuronal activity of the extrapyramidal motor systems in both hemispheres. these findings also support the concept that apparent neuronal plasticity in this primate telencephalic system is a result of ... | 1979 | 119189 |
| experimental trypanosoma cruzi infection in rhesus monkeys 111. electrocardiographic and histopathological findings. | in five rhesus monkeys surviving 'peru strain' or 'strain 7' trypanosoma cruzi infection for six to eight years, positive xenodiagnosis results and high indirect fluorescent antibody titres (4096 - 65536) persisted until the animals were killed. abnormal electrocardiograph patterns in two monkeys (h and k) were possibly compatible with myocardial damage. histopathological changes attributable to t. cruzi infection were minor in four monkeys but severe in one (r). in this animal, infected with wh ... | 1979 | 119339 |
| responses to wavelength contrast in the afferent visual systems of the cat and the rhesus monkey. | 1979 | 119347 | |
| biotransformation of diclofenac sodium (voltaren) in animals and in man. ii. quantitative determination of the unchanged drug and principal phenolic metabolites, in urine and bile. | 1. quantitative determinations of unchanged diclofenac and two of its major phenolic metabolites were made by reverse isotope dilution analysis on urine of rat, dog, rhesus monkey, baboon and man and on bile of rat, dog and man. isotope dilution analysis was performed before and after various methods of enzymic and chemical hydrolysis. 2. the same samples were also analysed by two-dimensional t.l.c. and subsequent autoradiography, to estimate the remaining phenolic metabolites. 3. in contrast to ... | 1979 | 119353 |
| [parasitic fauna of the rhesus monkey (macaca mulatta) and of the (macaca irus)]. | 1979 | 119389 | |
| anatomy of the auditory tube and related structures in the rhesus monkey (macaca mulatta). | the primate nasopharynx-auditory tube-middle ear complex is being used by several researchers to model both normal and pathologic functions of the human auditory tube. an extensive search of the literature has indicated little detailed information on the primate tube/middle ear system. this study was undertaken to define the anatomical characteristic of the system in the rhesus monkey (macaca mulatta) and to determine the limits on the use of the monkey as a model of human tubal function. althou ... | 1979 | 119421 |
| evaluation of various doses of testosterone on accessory reproductive organs and plasma testosterone in intact and gonadectomized rhesus monkeys (macaca mulatta). | the effect of 10 days i.m. treatment of testosterone propionate (tp) on plasma testosterone and accessory reproductive organs were studied in adult (6 to 6 1/2 kg) male rhesus monkeys, housed under natural light conditions using six different dose levels. the study was scheduled in the month of september and october. to maintain the weight of accessory reproductive organs and testosterone levels in castrates, different dose levels of exogenous testosterone propionate were required: 3.2 mg/d for ... | 1979 | 119450 |
| the effect of hemorrhagic shock on plasma amino acids and tissue energy substrates in the primate. | levels of plasma amino acids and muscle concentrations of energy substrates and metabolites after shock in the macaca mulatta rhesus monkey were investigated. the hemodynamic response to shock is similar to that of previously reported studies of primates in shock. plasma glucose and asat increased significantly, while levels of alat and pyruvic acid did not change. lactic acid was elevated. muscle glycogen and concentrations of lactic acid were increased, and levels of pyruvic acid, creatine pho ... | 1979 | 119453 |
| continuous transcutaneous oxygen tension measurements in experiments with juvenile rhesus monkeys and pregnant ewes. | 1979 | 119559 | |
| ultrastructure of synapses and cellular relationships in the oculomotor nucleus of the rhesus monkey. | the fine structure of synapses and of cellular relations was examined in the somatic efferent portion of the oculomotor nucleus of the adult rhesus monkey. axosomatic and axodendritic synapses are characterized by distinct synaptic clefts which usually measure 20-30 nm between pre- and postsynaptic membranes. cytoplasmic "thickenings" of pre- and postsynaptic membranes are often observed. subjunctional bodies are present at both axosomatic and axodendritic synapses. somatic and dendritic spine s ... | 1979 | 119578 |
| prolonged shock in the monkey following live e coli organism infusion. | responses of the rhesus monkey to the administration of live escherichia coli organisms during an observation of 0--27 hours were studied. nine monkeys were infused for 30 minutes with live e coli organisms, the dose ranging between 7.6 x 10(9) and 3.0 x 10(11) organisms/kg. three of nine animals survived for 24 hours or longer. nonsurvivors demonstrated significant hypotension, hypoglycemia, and hypoinsulinemia, while survivors showed lesser degrees of physiologic derangement. findings were hep ... | 1979 | 119585 |
| treatment of rhesus monkeys (macaca mulatta) with intravaginal rings loaded with levonorgestrel. | the effects of levonorgestrel-releasing intravaginal rings were investigated in 15 rhesus monkeys for 52 weeks. the intravaginal rings were designed to provide a sustained release of either three or ten times the human dose level of the hormone. untreated placebo rings were used as a control. the devices were well retained. after insertion of the vaginal rings, a dose-related decrease in vaginal bleeding was observed. the vaginal microbial flora were assessed qualitatively and semi-quantitativel ... | 1979 | 119606 |
| the rabbit as an animal model to study pharmacokinetics of norethindrone in women. | the pharmacokinetics of norethindrone (net) were studied in adult female rabbits and rhesus monkeys with a view to developing an animal model closely resembling humans in the handling of net. plasma levels of net were determined in rabbits and monkeys after administering either labelled net or a net minipill. pharmacokinetic parameters were evaluated by using a two-compartment open model and by graphical and regression analysis of plasma net data. in rabbits, the drug absorption was found to be ... | 1979 | 119608 |
| the acute behavioral effects of diisopropyl fluorophosphate in the chicken, pigeon, and rhesus monkey. | 1979 | 119626 | |
| absence of fatty livers in rhesus monkeys fed orotic acid. | pairs of rhesus monkeys were fed for 10 wk a basal diet containing 1% orotic acid or 10% nonfat milk powders. amounts of total lipids in the liver and hepatic morphology were normal after 10 wk indicating that orotic acid in the diet did not induce fatty livers in rhesus monkeys. | 1979 | 119795 |
| reproductive and hormonal patterns in the african green monkey (cercopithecus aethiops). | the results of breeding cercopithecus aethiops under time-mated laboratory conditions and analysis of total estrogen, progesterone, and lh concentrations in plasma during the menstrual cycle and plasma estrogen and progesterone concentrations during pregnancy indicate that this species is a suitable alternative for the rhesus monkey as a model for investigations of reproductive function in man. | 1979 | 119860 |
| preimplantation rhesus monkey blastocyst: secretion of substance capable of stimulating progresterone secretion by granulosa cell cultures. | 1979 | 119895 | |
| classical conditioning of blood pressure in macaca mulatta with cardiac rate controlled. | 2006 | 119942 | |
| reinforcing properties of some local anesthetics in rhesus monkeys. | the reinforcing properties of several local anesthetics were determined in rhesus monkeys experienced in the intravenous self-injection of cocaine. intravenous procaine and, occasionally, tetracaine maintained response rates higher than did vehicle injections in most monkeys. in contrast, lidocaine, procainamide and diethylaminoethanol (a metabolite of procaine) failed to maintain responding resulting in their intravenous delivery. these results demonstrate that not all local anesthetics are pos ... | 1979 | 119976 |
| enhanced allograft survival in rhesus monkeys treated with anti-human thymocyte globulin and donor lymphoid cells. | 1979 | 120017 | |
| synchronization of eeg activity of male rhesus monkeys macaca mulatta treated with ovocyclin. | bipolar stainless steel electrodes were stereotaxically implanted in hypothalamus and cortex of six male monkeys. the effect of intramuscular injection of estradiol dipropionate (ovocyclin) in a dose of 10 mg/d was observed on eeg activity on 3 successive days. on the first day, slow waves appeared only in preoptic and on the second day also in posterior hypothalamus. generalized slowing with an increase in amplitude appeared in all the hypothalamic areas and cortex on the third day. this sugges ... | 1979 | 120113 |
| antimalarial activity of floxacrine (hoe 991) i. studies on blood schizontocidal action of floxacrine against plasmodium berghei, p. vinckei and p. cynomolgi. | floxacrine (hoe 991), 7-chloro-10-hydroxy-3-(4-trifluoromethylphenyl)3,4-dihydroacridine-1,9-(2h, 10h) dion, shows a high level of antimalarial action against blood-induced infection of drug-sensitive and drug-resistant lines of plasmodium berghei in mice, rats and syrian hamsters. the drug is also a potent blood schizontocide against drug-sensitive p. vinckei strains in rodents and p. cynomolgi in rhesus monkeys. the cd50/cd90 values against the drug-sensitive p. berghei strain ascertained in t ... | 1979 | 120142 |
| an in vivo strain-gauge analysis of the squamosal-dentary joint reaction force during mastication and incisal biting in macaca mulatta and macaca fascicularis. | 1979 | 120172 | |
| beta-galactoside-binding muscle lectins of man and monkey show antigenic cross-reactions with those of bovine origin. | endogenous beta-galactoside-binding lectins were isolated from human heart and from human and rhesus-monkey skeletal muscles. gel precipitation and radioimmunoassays with rabbit antisera to calf heart lectin revealed antigenic cross-reactions between the primate and bovine muscle lectins. | 1979 | 120198 |
| an effective rabies treatment in exposed monkeys: a single dose of interferon inducer and vaccine. | rhesus monkeys were injected with lethal doses of rabies virus and then treated with a variety of treatment combinations. the one found most successful was one dose of an interferon inducer (poly(i)-poly(c) complexed to poly-l-lysine and carboxymethyl-cellulose) and one dose of human diploid rabies vaccine. this combination proved to be as effective as hyperimmune serum and vaccine, and much better than vaccine alone. the combination of the interferon inducer plus vaccine could be administered a ... | 1979 | 120234 |
| chronic toxicity studies of a hypoglycemic compound: centperalone in rats & rhesus monkeys. | 1979 | 120313 | |
| determination of 6-mercaptopurine and azathioprine in plasma by high-performance liquid chromatography. | using 1-ml plasma samples, levels of 6-mercaptopurine (6mp) as low as 5 ng/ml and azathioprine (aza) as low as 40 ng/ml can be detected using a high-performance liquid chromatography reversed-phase column procedure following extraction. both compounds were stable in frozen plasma for seven weeks. aza stability in blood was temperature dependent; the half-lives of aza breakdown to 6mp at 37 degrees were 28 and 46 min in blood drawn from two rhesus monkeys. plasma levels of 6mp were measured in a ... | 1979 | 120373 |
| the mode of migration of neurons to the hippocampus: a golgi and electron microscopic analysis in foetal rhesus monkey. | the mode of neuron migration from the site of their origin in the ventricular zone to area ca1 of the hippocampus was analysed with golgi and electron microscopic methods during the first half of gestation in the foetal rhesus monkey. in the inner portion of the intermediate zone, the migrating cells have a bipolar form with one, or oaccasionally two, leading processes which do not reach the ammonic plate and with a single trailing process which usually ends within the intermediate zone. both th ... | 1979 | 120417 |
| selection and pairing of 'normal' rhesus monkeys (macaca mulatta) for research: procedures, techniques, and observations. | a selection process has been developed by the authors to insure investigators that animal subjects used in their experiments will accurately reflect biological changes associated with the project design. the procedure involved the following: complete physical examination; complete hemogram, serum electrolytes, serum biochemistry, body weight; and anthropometric determinations; aging by dentition; electrocardiography; total-body radiography; fecal culture; fecal ova, and parasite examinations; an ... | 1979 | 120443 |
| differentiation of coital behavior in mammals: a comparative analysis. | the evidence reviewed suggests that in all mammalian species the adult male's ability to display masculine coital behavior depends in part on exposure of the developing brain to testicular testosterone or its metabolites. in many mammals, particularly rodents, ruminants, and some carnivores, perinatal exposure to androgen also causes behavioral defeminization, i.e., reduced capacity to display typically feminine coital behavior in response to gonadal hormones in adulthood. the data reviewed sugg ... | 1979 | 120519 |
| effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on indocyanine green blood clearance in rhesus monkeys. | to assess effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on liver function adult male rhesus monkeys were treated with a single oral dose of acetone/corn oil (control) or 5, 25, or 75 micrograms/kg tcdd. each monkey was used as its own control and indocyanine green (icg) blood clearance and the following serum enzymes: glutamic pyruvate transaminase (sgpt), sorbitol dehydrogenase (sdh) and gamma glutamyl transpeptidase (gamma gtp), were measured at regular intervals for 4 weeks before and ... | 1979 | 120621 |
| fractionation of plasmodium knowlesi-induced antigens of rhesus monkey erythrocyte membranes. | in order to characterize parasite-induced host cell membrane antigens, the plasma membranes of plasmodium knowlesi-infected rhesus erythrocytes have been compared with those of normal red cells and purified schizonts by immunochemical and biochemical techniques. host cell membranes and schizonts were separated by differential centrifugation following nitrogen decompression. isolated schizonts were further fractionated into several subcellular compartments. crossed-immune electrophoresis, against ... | 1979 | 120762 |
| immunization of rhesus monkeys with blood-stage antigens of plasmodium knowlesi. | evaluation of the efficacy of 3 nonviable blood-stage antigens-schizont ag, merozoite ag, and "french press" ag-of plasmodium knowlesi, emulsified in freund's complete adjuvant (fca), was carried out in a study involving 32 rhesus monkeys. after 2 immunizations, administered 6 weeks apart, monkeys were challenged with a variant of p. knowlesi different from that used for immunization. all 8 control monkeys that received either pbs or fca developed a severe parasitaemia and died of the infection ... | 1979 | 120763 |
| preliminary studies on vaccination of rhesus monkeys with irradiated sporozoites of plasmodium knowlesi and characterization of surface antigens of these parasites. | studies were conducted to develop an effective method of inducing protection against sporozoite-induced malaria in a primate system and to obtain information regarding the surface membrane antigens of sporozoites. immunization of rhesus monkeys was performed with gamma-irradiated sporozoites of plasmodium knowlesi. levels of antisporozoite antibodies were monitored by immunofluorescence, sporozoite neutralization, and the circumsporozoite precipitate reaction, and appeared to correlate well with ... | 1979 | 120766 |