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production of macrophage migration inhibition factors by virus-infected cell cultures.macrophage migration inhibitory (mif-like) activity was demonstrated in the supernatant fluids from cultures of african green monkey kidney cells (bgm) infected with mumps virus or newcastle disease virus. we could detect no such activity in noninfected cultures. the virus-induced activity reported here is not due to nonspecific cytotoxic material released by dead or dying cells, and it does not require cell replication for its production. preliminary estimates of molecular weight by sephadex g- ...19734199152
long term infection of diploid african green monkey brain cells by schwarz measles vaccine virus. 19734200695
serial passage of 3 strains of avian infectious bronchitis virus in african green monkey kidney cells (vero). 19734203249
susceptibility and immune response to experimental plague in two species of langurs and in african green (grivet) monkeys. 19744207625
the indirect immunoenzyme test for the detection of antibodies against north american borreliae. i. technic and results with sera of vervet monkeys (cercopithecus aethiops). 19744208886
fate of auricular transplants and repair of auricular gaps in the grivet monkey (cercopithecus aethiops aethiops). 19744211009
[a comparison of the pathogenicity of two strains of schistosoma mansoni in cercopithecus aethiops monkeys in the sudan]. 19744214855
some biochemical characteristics of the salivary gland products of macaca irus and cercopithecus aethiops. 19744215613
restriction endonuclease cleavage maps of animal mitochondrial dnas.the restriction endonuclease, hindiii, gives rise to three fragments in each of the three mitochondrial dnas isolated from the established mammalian cell lines la9 (mouse), hela (human), and bsc-1 (african green monkey). the restriction endonuclease, ecori, gives rise to three fragments in mitochondrial dna from hela and to two in dnas from la9 and bsc-1. the sizes and the orders of the fragments in the respective genomes have been determined with data obtained from the electron microscope. the ...19744216020
the st. kitts vervet (cercopithecus aethiops). 19744216632
an anatomical study of the pineal body of the vervet monkey (cercopithecus aethiops). 19744216961
a histochemical study of the pineal body of the vervet monkey (cercopithecus aethiops). 19744216962
the presence of capillaria hepatica (bancroft, 1893) travassos, 1915 in a vervet monkey cercopithecus aethiops. 19744217471
single and repeated infections of grivet monkeys with schistosoma mansoni: parasitological and pathological observations over a 31-month period.groups of 6 to 8 grivet monkeys (ceropithecus aethiops aethiops), each of which had been exposed to 600 cercariae of schistosoma mansoni, were killed 3, 6, and 31 months after exposure. other groups of monkeys were repeatedly challenged with cercariae beginning 4 or 23 months after the initial infection, and were killed 31 months after the first exposure. peripheral blood leukocytes, eosinophiles, and schistosome eggs passed in the feces were determined during the course of the infection. at aut ...19744217568
experimental louse-borne relapsing fever in the grivet monkey, cercopithecus aethiops. i. clinical course.fifteen grivet monkeys, cercopithecus aethiops, were infected with an ethiopian strain of borrelia recurrentis, the causative agent of louse-borne relapsing fever. an initial spirochetemia occurred in all. inactivity, fever, and leukocytosis accompanied the infections. eight of the monkeys experienced 1 relapse and 1 monkey had 2 relapses. the relapses tended to be less severe than the initial infections. the only deaths, however, occurred in 2 of the 3 monkeys with severe relapses. the clinica ...19744217570
experimental louse-borne relapsing fever in the grivet monkey, cercopithecus aethiops. ii. pathology.nineteen grivet monkeys, cercopithecus aethiops, were infected with the spirochete of louse-borne relapsing fever, borrelia recurrentis, and killed at various intervals following inoculation: 4 during the initial spirochetemia; 4 during remission; 3 during relapse; 2 that were dying following severe relapses; and 6 during convalescence. the histologic changes of histiocytic myocarditis, multiple microabscesses replacing the nodular white pulp of the spleen, and hepatitis with foci of midzonal ne ...19744217571
experimental louse-borne relapsing fever in the grivet monkey, cercopithecus aethiops. iii. crisis following therapy.eight grivet monkeys infected with borrelia recurrentis received tetracycline (12.5mg/kg body weight) on the 3rd or 4th day of spirochetemia. leukopenia, fever, hyperpnea, and tachycardia developed within 2 hours as spirochete counts fell to undetectable levels. these events closely simulated the crisis in human louse-borne relapsing fever in both timing and extent.19744217572
baseline karyologic values for primary rhesus and african green monkey cell cultures. 19744218606
3-hydroxyaflatoxin b1: a new metabolite of in vitro aflatoxin b1 metabolism by vervet monkey (cercopithecus aethiops) liver. 19744218848
values for blood constituents of the african green monkey (cercopithecus aethiops). 19674228551
bordetella bronchiseptica isolated from a fatal case of bronchopnuemonia in an african green monkey. 19684233379
[habituation of the vertex point in 2 african monkeys, erythrocebus patas and cercopithecus aethiops]. 19694238896
sparganosis in african green monkeys (cerocopithecus aethiops). 19694240237
[steroid metabolism in primates. v. isolation of dehydroepiandrosterone, androstenedione and adrenosterone from adrenal venous blood of macacus rhesus, papio hamadryas, cercopithecus aethiops and erythrocebus patas]. 20144243440
the isolation and identification of mycoplasma from cercopithecus aethiops. 19704247045
transformation of african green monkey kidney cultures infected with simian vacuolating virus (sv40). 19654284197
studies of adenovirus sv40 hybrid viruses. i. assay system and further evidence for hybridization.the titers of adenovirus and sv40 genetic carriers in hybrid preparations (e46(+)) can be quantitated by determining the percentage of cells showing neoantigens stainable with fluorescent antibody (fa) at 21 to 24 hours; both titers can be obtained with a single coverslip. the adenovirus and sv40 antigen-inducing titers so obtained are of the same order of magnitude in stock preparations of e46(+) grown in either african green monkey kidney (agmk) or human embryonic kidney tissue culture (hek), ...19654285252
incomplete growth of simian virus 40 in african green monkey kidney culture induced by serial undiluted passages. 19664285471
a comparison of the replication cycles of simian virus 40 in human diploid and african green monkey kidney cells. 19664285472
[incomplete growth of simian virus 40 in african green monkey kidney cell culture induced by serial undiluted passages]. 19654285732
virus: mixed infection with herpes simplex and simian virus 40.mixed infection, the infection of a single cell by two distinguishable viruses, has been demonstrated by electron microscopy in cultures of african green monkey kidney cells after inoculation with simian virus 40 and herpes simplex. mixed infection occurs rarely when the two viruses are inoculated simultaneously, but if herpes is inoculated 24 hours after sv40 both viruses are found in the same nucleus in about 5 percent of intact cells.19664286323
effects of cycloheximide and puromycin on synthesis of simian virus 40 t antigen in green monkey kidney cells.gilden, r. v. (wistar institute, philadelphia, pa.), and r. i. carp. effects of cycloheximide and puromycin on synthesis of simian virus 40 t antigen in green monkey kidney cells. j. bacteriol. 91:1295-1297. 1966.-synthesis of the simian virus 40 (sv40) t antigen in primary african green monkey kidney cells was abolished when cycloheximide was added up to 10 hr postinfection. in contrast, puromycin, another inhibitor of protein synthesis, did not suppress antigen production. the basis of this di ...19664286450
potentiation of oncogenicity of adenovirus type 12 grown in african green monkey kidney cell cultures preinfected with sv40 virus. persistence of both t antigens in the tumors and evidence for possible hybridization. 19664287351
mixed infection of african green monkey kidney cells by adenovirus 7 and sv 40. 19654288171
mutants of simian virus 40 differing in plaque size, oncogenicity, and heat sensitivity.takemoto, k. k. (national institute of allergy and infectious diseases, bethesda, md.), r. l. kirschstein, and k. habel. mutants of simian virus 40 differing in plaque size, oncogenicity, and heat sensitivity. j. bacteriol. 92:990-994. 1966.-three mutants of simian virus 40 were isolated on the basis of the type of plaques produced in primary cultures of african green monkey kidney cells and designated as l (large), s (small), and m (minute) strains. significant differences in oncogenicity for h ...19664288804
production of varicella-zoster cf antigen in a continuous line of grivet monkey kidney cells. 19664289537
[properties of r-1ca cell lines obtained from kidney cells of cercopithecus aethiops cultured in vitro]. 19664290767
isolation of sv40 virus and its effect on renal function in african green monkeys. 19674293260
rubella virus: role of interferon during infection of african green monkey kidney tissue cultures. 19674293995
studies on the mechanism of enhancement of adenovirus 7 infection in african green monkey cells by simian virus 40: formation of adenovirus-specific rna. 19684295919
serologic screening of rhesus and grivet monkeys for sv40 and the foamy viruses. 19684296246
agent of disease contracted from green monkeys.an infectious agent obtained from patients who became ill after exposure to tissues of african green monkeys is viral in character. by electron microscopy, the agent appeared cylindrical, 90 to 100 nanometers in diameter, and 130 to 2600 nanometers in length. cross-striations at 5-nanometer intervals and a core diameter of 45 nanometers were observed. the agent was completely resistant to the effects of the metabolic inhibitor 5-bromodeoxyuridine, which may mean that rna is the genetic material. ...19684296724
[studies on safety tests of inactivated poliomyelitis vaccines. iv. comparative safety tests in rhesus monkeys and long-tailed monkeys (cercopithecus aethiops)]. 19664296870
[studies on safety tests of inactivated poliomyelitis vaccines. v. pathomorphological changes in the cns of rhesus monkeys (macaca rhesus) and long-tailed monkeys (cercopithecus aethiops) following intracerebral and intralumbar inoculation with inactivated poliovirus types i, ii, and 3]. 19664296871
production of reference enteroviruses.forty-five human enterovirus reagents of certified purity and quality were prepared for use as seed viruses and as immunizing antigens. one of the reagents was ampouled as "untreated" seed virus, whereas 14 were ampouled as "mgcl(2)-stabilized" reagents. the remaining 30 reagents were ampouled as "untreated" seed viruses and as "mgcl(2)-stabilized" reagents. thirty of the reagents were propagated on primary african green monkey kidney cells, 3 on primary baboon kidney cells, 3 on primary rhesus ...19684300898
a virus disease of captive vervet monkeys (cercopithecus aethiops) caused by a new herpesvirus. 19674301195
defectiveness of interferon production and of rubella virus interference in a line of african green monkey kidney cells (vero).vero cells, a line of african green monkey kidney cells, failed to produce interferon when infected with newcastle disease, sendai, sindbis, and rubella viruses, although the cells were sensitive to interferon. further, infection of vero cells with rubella virus did not result in interference with the replication of echovirus 11, newcastle disease virus, or vesicular stomatitis virus, even in cultures where virtually every cell was infected with rubella virus. under the same conditions, bsc-1 ce ...19684302013
various antibody holding status against viruses in cercopithecus aethiops and macaca irus. i. the presence of neutralizing antibodies to measles virus and polio virus. 19674303327
various antibody holding status against viruses in cercopithecus aethiops and macaca irus. ii. the presence of neutralizing antibody against herpes virus, echo virus and simian virus 40. 19674303328
effect of actinomycin-d on dna synthesis in african green monkey kidney cultures uninfected and infected with sv40. 19684303471
markers of rubella virus strains in rk13 cell culture.when tested on rk(13) cell cultures, strains of rubella virus could be differentiated by their ability to form small or large plaques. large plaques were produced by the hpv-77 and cendehill strains, and also by a laboratory stock strain (west point), after only 14 passages in rk(13) culture. five wild-type rubella viruses, isolated and passaged only a few times in african green monkey kidney tissue culture, grew well in rk(13) cell culture, but they were sensitive to agar inhibitors and, theref ...19694304446
plaque formation by herpes simplex viruses in gmk (established grivet monkey kidney) cells. 19684304631
cytomegaloviruses as common adventitious contaminants in primary african green monkey kidney cell cultures. 19694305018
simian virus 40 infection of uninoculatedafrican green monkeys (cercopithecus aethiops) revealed by repeated cell passages. 19694306707
site of host restriction of simian virus 40 mutants in an established african green monkey kidney cell line.a previously described large-plaque morphology mutant of sv40 (sv-l) in primary african green monkey kidney (agmk) cells has been shown to be restricted in the established agmk line cv-1. the site of restriction is an early step in infection, involving the virus particle. a block in penetration or uncoating has been tentatively proposed. restriction is observed in a number of other established lines, including monkey, human, and mouse. independent large-plaque mutants were isolated in agmk and t ...19694309877
various antibody holding status against viruses in cercopithecus aethiops and macaca irus. 3. the presence of antibodies to coxsackie, rubella, japanese encephalitis, influenza and parainfluenza viruses. 19684310558
malignant transformation of an established kidney cell line from african green monkey by the schmidt-ruppin strain of rous sarcoma virus. 19694310799
a nondefective (competent) adenovirus-sv40 hybrid isolated from the ad.2-sv40 hybrid population.a new nondefective hybrid virus has been plaque-isolated from the ad.2-sv40 hybrid population. this virus replicates efficiently with one-hit kinetics in both human embryonic kidney and african green monkey kidney cells, induces an sv40 specific antigen which is detectable by immunofluorescence and complement-fixation using sera from sv40 tumor-bearing hamsters, and produces sv40-specific rna detectable by dna-rna hybridization. the sv40-specific antigen induced by this virus is heat-stable, sen ...19694311250
vero cells (cercopithecus aethiops kidney)--growth characteristics and viral susceptibility for use in diagnostic virology. (brief report). 19694313210
adventitious agents in african green monkey kidney tissue cultures used for the production of live attenuated poliomyelitis vaccine. 19694314437
proteins specified by herpes simplex virus. 3. viruses differing in their effects on the social behavior of infected cells specify different membrane glycoproteins.we examined the electrophoretic properties of the proteins and glycoproteins in the smooth membranes and virions purified from cells infected with herpes simplex virus strains differing with respect to their effects on the interaction of cells among themselves. the data show the following: (1) the glycoproteins in virions and binding to membranes share common features but vary quantitatively and qualitatively depending on the virus strain. (2) the binding to smooth membranes is ordered and not r ...19704314902
initial site of synthesis of virus during rescue of simian virus 40 from heterokaryons of simian virus 40-transformed and susceptible cells.simian virus 40 (sv40) can be rescued from certain sv40-transformed hamster cells by fusion with susceptible african green monkey kidney (cv-1) cells, in the presence of ultraviolet-irradiated sendai virus. we have determined the sites in which sv40 is produced during rescue in these heterokaryons. to determine the sequence, nuclei were isolated from fused cells at various times after fusion, separated on sucrose-density gradients, and assayed for infectious center formation and virus content on ...19704315957
biochemical consequences of type 2 adenovirus and simian virus 40 double infections of african green monkey kidney cells.african green monkey kidney (agmk) cells were nonpermissive hosts for type 2 adenovirus although the restriction was not complete; when only 3 plaque-forming units/cell was employed as the inoculum, the viral yield was about 0.1% of the maximum virus produced when simian virus 40 (sv40) enhanced adenovirus multiplication. the viral yield of cells infected only with type 2 adenovirus increased as the multiplicity of infection was increased. type 2 adenovirus could infect almost all agmk cells in ...19704315958
transformation of african green monkey kidney cells by irradiated adenovirus 7-simian virus 40 hybrid.the ability of adenovirus 7-simian virus 40 (sv40) hybrid (strain ll "e-46") to replicate decreased exponentially as a function of the amount of gamma-irradiation; the ability to induce sv40 and adenovirus 7 t antigen decreased at a much slower rate. nevertheless, the virus was still able to transform african green monkey kidney cells at a radiation dosage that had completely destroyed its replication ability. all transformed colonies were positive for sv40 t antigen but were negative for adenov ...19684316019
deoxyribonucleic acid replication in simian virus 40-infected cells. 3. comparison of simian virus 40 lytic infection in three different monkey kidney cell lines.a comparative study of simian virus 40 (sv40) lytic infection in three different monkey cell lines is described. the results demonstrate that viral deoxyribonucleic acid (dna) synthesis and infectious virus production begin some 10 to 20 hr earlier in cv-1 cells and primary african green monkey kidney (agmk) cells than in bsc-1 cells. induction of cellular dna synthesis by sv40 was observed in cv-1 and agmk cells but not with bsc-1 cells. excision of large molecular weight cellular dna to smalle ...19704317114
a study of new and old world monkeys to determine the likelihood of a simian reservoir of smallpox.the author presents data indicating that three species of new world monkeys (cebus apella, ateles paniscus, lagothrix lagothricha) are not susceptible to brazilian variola minor. although the number of animals tested was not large, no experimental evidence was obtained to suggest that these species could form a non-human reservoir for smallpox in the western hemisphere. the results also indicate that cercopithecus aethiops are not very susceptible to infection with either variola major or minor. ...19704317468
[prevalence of antibodies against viruses in cercopithecus aethiops and macaca irus]. 19704317695
biological characteristics of cell line gl-v3 derived from the kidney of a vervet monkey (cercopithecus aethiops). 19704318075
isolation of two plaque variants from the adenovirus type 2-simian virus 40 hybrid population which differ in their efficiency in yielding simian virus 40.studies on the adenovirus type 2-simian virus 40 (sv40) hybrid population demonstrated two genetically stable variants within this population, which were isolated by plaquing in african green monkey kidney cells. these variants were similar in that each induced sv40 t antigen in human embryonic kidney cells and contained similar concentrations of nonhybrid adenovirus type 2 virions and adenovirus-encapsidated particles containing the infectious sv40 genome. these variants differed markedly, howe ...19704318083
equilibrium density gradient studies on simian virus 40-yielding variants of the adenovirus type 2-simian virus 40 hybrid population.the simian virus 40 (sv40)-yielding variants of the adenovirus type 2 (ad.2)-sv40 hybrid (ad.2(++)) population were studied by means of fixed-angle equilibrium density gradient centrifugation in cesium chloride. the hybrid virions of the ad.2(++) high-efficiency yielder population banded at densities of 0.004 g/cm(3) lighter than the nonhybrid ad.2 virions. the degree of separation of the hybrid particles was sufficient to permit greater than 100-fold relative purification by two cycles of centr ...19704318084
deoxyribonucleic acid replication in simian virus 40-infected cells. ii. detection and characterization of simian virus 40 pseudovirions.purified simian virus 40 (sv40) virions, grown in primary african green monkey kidney cells labeled prior to infection with (3)h-thymidine, contain a variable quantity of (3)h-labeled deoxyribonucleic acid (dna). this dna is resistant to deoxyribonuclease, sediments at 250s, and is enclosed in a particle that can be precipitated with sv40-specific antiserum. dna-dna hybridization experiments demonstrate that this (3)h-labeled component in purified sv40 virions is cellular dna. when this (3)h-lab ...19704318087
identification of the simian virus 40 which replicates when simian virus 40-transformed human cells are fused with simian virus 40-transformed mouse cells or superinfected with simian virus 40 deoxyribonucleic acid.simian virus 40 (sv40) was rescued from heterokaryons of transformed mouse and transformed human cells. to determine whether the rescued sv40 was progeny of the sv40 genome resident in the transformed mouse cells, the transformed human cells, or both, rescue experiments were performed with mouse lines transformed by plaque morphology mutants of sv40. the transformed mouse lines that were used yielded fuzzy, small-clear, or large-clear plaques after fusion with cv-1 (african green monkey kidney) ...19704319481
temperature-sensitive simian virus 40 mutant defective in a late function.a temperature-sensitive simian virus 40 (sv40) mutant, tstng-1, has been isolated from nitrosoguanidine-treated and sv40-infected african green monkey kidney (cv-1) cultures. replication of virus at the nonpermissive temperature (38.7 c) was 3,000-fold less than at the permissive temperature (33.5 c). plaque formation by sv40tstng-1 deoxyribonucleic acid (dna) on cv-1 monolayers occurred normally at 33.5 c but was grossly inhibited at 38.7 c. the time at which virus replication was blocked at 38 ...19704320387
transformation of mouse macrophages by simian virus 40.studies were undertaken to prove that simian virus 40 (sv40) can transform the mouse macrophage, a cell type naturally restricted from deoxyribonucleic acid (dna) replication. balb/c macrophages infected with sv40 demonstrated t-antigen production and induced dna synthesis simultaneously. in the absence of apparent division, these cells remained t antigen-positive for at least 45 days. sv40 could be rescued from nondividing, unaltered macrophages during the t antigen-producing period. proliferat ...19704320698
various antibodies holding status against viruses in cercopithecus aethiops and macaca irus. iv. the presence of antibodies against viruses of human and simian origin. 19694321641
induction of mitochondrial dna synthesis in monkey cells infected by simian virus 40 and (or) treated with calf serum.infection of confluent monolayer cultures of african green monkey kidney cells with simian virus 40 results in an enhanced synthesis of nuclear and mitochondrial dna. this is demonstrated both by an increased rate of incorporation of [(3)h]thymidine into mitochondrial dna and by detection of increased amounts of mitochondrial dna in infected cells. with monkey bsc-1 cells, where sv40 infection does not result in a stimulation of nuclear dna synthesis, no stimulation of mitochondrial dna synthesi ...19714323784
identification and properties of complex forms of sv40 dna isolated from sv40-infected african green monkey (bsc-1) cells. 19714324632
quantitation of simian virus 40 sequences in african green monkey, mouse and virus-transformed cell genomes. 19714325134
growth of murine cytomegalovirus in various cell lines.murine cytomegalovirus (mcmv) was capable of infecting and replicating in both primary and continuous cell lines obtained from various species. in african green monkey kidney (bsc-1) cells, primary rabbit kidney cells, and baby hamster kidney (bhk-21) cells, there were cytopathic effects (cpe) and virus replication upon initial exposure of cells to virus. in primary fetal sheep brain (fsb) cells, l cells, and rabbit kidney (rk-13) cells, it was necessary to subculture the infected cells one or m ...19714327583
sero-epidemiological survey on yaba and 1211 virus infections among several species of monkeys.the distribution of neutralizing antibody to yaba virus and 1211 agent in the sera of three asian and one african monkey species was examined.cynomolgus (macaca irus), bonnet (m. radiata) and rhesus (m. mulatta) monkeys possessed antibody to yaba virus at incidences of 19.9, 8.4 and 0%, respectively. in african green monkeys (cercopithecus aethiops) the incidence was as high as 76.4%.as for 1211 agent, no asian monkeys had neutralizing antibody and 5.5% of african green monkey sera neutralized t ...19714328796
mechanism of host cell restriction in african green monkey kidney cells abortively infected with human adenovirus type 2. 19714329349
nucleoprotein complexes in simian virus 40-infected cells.when african green monkey kidney cells (bsc-1) were infected with simian virus 40 (sv40) and extracted with 0.25% triton x-100 after exposure to (3)h-thymidine, the (3)h-sv40 deoxyribonucleic acid (dna) was present in a form which had a sedimentation coefficient in sucrose gradients of 44s. the change from the sedimentation coefficient of purified sv40 dna (21s) was shown to result from the association of the sv40 dna in the triton extracts with protein by means of sensitivity to pronase digesti ...19714331646
spontaneous virus production by clonal lines of siminan virus 40-transformed cells and effects of superinfection by deoxyribonucleic acid from mutant simian virus 40 strains.small amounts of infectious simian virus 40 (sv40) were recovered from parental cultures of sv40-transformed human embryonic lung (wi38 va13a) cells, from 12 primary clones, from 17 secondary clones, and from 18 tertiary clones. the cloning experiments demonstrated that the capacity for spontaneous virus production is a hereditary property of wi38 va13a cells. infectious virus was not recovered from every clone at every passage. repeated trials at different passage levels were necessary to detec ...19714331650
structure of replicating simian virus 40 deoxyribonucleic acid molecules.properties of replicating simian virus 40 (sv40) deoxyribonucleic acid (dna) have been examined by sedimentation analysis and by direct observation during a lytic cycle of infection of african green monkey kidney cells. two types of replicating dna molecules were observed in the electron microscope. one was an open structure containing two branch points, three branches, and no free ends whose length measurements were consistent with those expected for replicating sv40 dna molecules. a second spe ...19714331651
preparation of type 2 herpes simplex virus complement-fixing antigen.comparable complement-fixing antigens of type 1 and type 2 herpes simplex virus were produced by extraction of infected african green monkey cells with 0.85% nacl which was buffered at ph 9.0 with 0.05 m glycine-naoh. the optimal antigen dilutions were higher in titrations against hyperimmune animal sera than in titrations against human sera. complement-fixing antibody to type 2 herpes antigen was detected in 5 of 17 sera from healthy humans.19714332046
some clinical and microbiological findings in vervet monkeys (cercopithecus aethiops pygerythrus). 19714332159
infection of primary african green monkey cells with sv40 monomeric and dimeric dna. 19714332233
a study of the ultrastructure of the small iris vessels in the vervet monkey (ceropithecus aethiops). 19724332349
synthesis and assembly of simian virus 40. ii. synthesis of the major capsid protein and its incorporation into viral particles.african green monkey kidney cells infected by simian virus 40 were analyzed for the presence of the major capsid protein (capsid protein i) by immunological and radiolabeling techniques. antisera with different specificities were prepared by immunization with intact or denatured viral particles. antisera prepared against intact virus reacted by complement fixation with viral particles and with an 8s subunit containing the capsid protein i. antisera prepared against denatured viral particles reac ...19724333545
epstein-barr virus in human lymphoblastoid cells: enhancing the percentage of virus-positive cells by cocultivation with african green monkey (vero) cells. 19714333665
antiviral activity in tissue culture systems of bis-benzimidazoles, potent inhibitors of rhinoviruses.(s,s)-1,2-bis(5-methoxy-2-benzimidazolyl)-1,2-ethanediol showed antiviral activity in monolayer tissue culture systems against 55 strains of rhinovirus, three types of poliovirus, and strains of type a and b coxsackieviruses. neither the compound nor any of the analogues tested showed virucidal activity. its antiviral activity was not associated with interference with viral attachment to or penetration into the cell. at a concentration of 0.1 mg/ml, this group of compounds was generally nontoxic ...19724333892
integration of simian virus 40 deoxyribonucleic acid into the deoxyribonucleic acid of permissive monkey kidney cells.integration of simian virus 40 (sv40) deoxyribonucleic acid (dna) into cellular dna occurred when permissive african green monkey kidney (cv-1) cells were infected at a low multiplicity of sv40 in the presence of cytosine arabinoside.19724336565
further studies on induced respiratory viral infection of vervet monkeys (cercopithecus aethiops). 19724338139
properties of an sv40-transformed african green monkey kidney (bsc-1) cell line. 19724339410
normal serum biochemical values of cercopithecus aethiops, cercocebus atys, and presbytis entellus. 19724343325
neutralizing antibodies to cytomegaloviruses in normal simian and human sera.simian and human sera were examined for neutralizing antibodies to simian and human cytomegaloviruses (cmv). neutralizing antibody to simian cmv was found in sera from 12 of 12 african green monkeys, 8 of 10 rhesus monkeys, and 7 of 7 baboons captured in the wild. the antibody did not cross-react with human cmv strain ad169 but cross-reacted with human strain c87, particularly in the presence of complement. thirty-six baboons and 10 rhesus monkeys born and hand-reared in captivity remained free ...19714343408
simian virus 40 deoxyribonucleic acid synthesis: the viral replicon.three temperature-sensitive (ts) mutants of simian virus 40 (sv40) in complementation group a (tsa7, tsa28, tsa30) have been isolated and characterized in permissive and restrictive host cells. at 41 c in the ah line of african green monkey kidney cells, the mutants are deficient in an early function required to produce infectious viral deoxyribonucleic acid (dna). temperature-shift experiments and analysis of sv40 viral dna replication by gel electrophoresis have provided strong evidence that t ...19724343541
structural proteins of simian virus 40: phosphoproteins.all five structural polypeptides of infectious simian virus 40 grown in african green monkey kidney cells were found to be phosphorylated. the polypeptides with the largest and smallest molecular weights are phosphorylated to a somewhat lower extent than the other polypeptides. the protein moiety of "empty" virus, which is essentially devoid of deoxyribonucleic acid, exhibited a degree of phosphorylation similar to that of infectious virus. in the major polypeptide (molecular weight: 49,000), th ...19724344258
transcription and transport of virus-specific ribonucleic acids in african green monkey kidney cells abortively infected with type 2 adenovirus.the techniques of deoxyribonucleic acid-ribonucleic acid (dna-rna) hybridization and immunological precipitation were used to compare the synthesis of adenovirus-specific macromolecules in african green monkey kidney (agmk) cells infected with adenovirus, an abortive infection, and coinfected with both adenovirus and simian virus 40 (sv40), which renders the cells permissive for adenovirus replication. when viral protein synthesis was proceeding at its maximum rate, the incorporation of (14)c-am ...19724345490
properties of an sv40 transformed african green monkey kidney (bsc-1) cell line: interactions between sv40 and cellular dna metabolism. 19734350222
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