Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| an evaluation of the marmoset callithrix jacchus (sagüi) as an experimental model for the dyslipoproteinemia of human schistosomiasis mansoni. | human infection with the parasite schistosoma mansoni is a relatively common occurrence in regions of south america and is associated with liver dysfunction and dyslipoproteinemia. specifically, the activity of plasma lecithin:cholesterol acyltransferase (lcat) activity is reduced, the concentration of plasma cholesterol esters falls, phospholipid concentrations are elevated and erythrocyte membranes become cholesterol enriched. previous studies have utilized rodents (rats and mice) as experimen ... | 1998 | 9748601 |
| behavioural effects of subthalamic nucleus lesions in the hemiparkinsonian marmoset (callithrix jacchus). | recent studies in non-human primates support a role for the subthalamic nucleus in the expression of parkinsonian symptomatology, and it has been proposed that subthalamic lesions may provide a surgical treatment for the symptoms of parkinson's disease in humans. we have applied a broad range of behavioural tests to characterize the effects of lesions of the subthalamic nucleus on parkinsonian symptoms in the unilateral 6-hydroxydopamine (6-ohda) lesioned marmoset (callithrix jacchus). thirteen ... | 1998 | 9749730 |
| the common marmoset: a new world primate species with limited mhc class ii variability. | the common marmoset (callithrix jacchus) is a new world primate species that is highly susceptible to fatal infections caused by various strains of bacteria. we present here a first step in the molecular characterization of the common marmoset's mhc class ii genes by nucleotide sequence analysis of the polymorphic exon 2 segments. for this study, genetic material was obtained from animals bred in captivity as well as in the wild. the results demonstrate that the common marmoset has, like other p ... | 1998 | 9751736 |
| growth of marmoset monkeys callithrix jacchus in captivity. | 1998 | 9751829 | |
| adenosine a2a receptors modify motor function in mptp-treated common marmosets. | both adenosine a1 and a2 receptor populations are located in the striatum and can modify locomotor activity, and they may form a therapeutic target for parkinson's disease (pd). administration of the selective adenosine a2a antagonist (e)-1,3-diethyl-8-(3,4-dimethoxystyryl)-7-methyl-3,7-dihydro-1h-pu rine-2,6-dione (kw-6002) to mptp-treated common marmosets increased locomotor activity. in contrast, administration of the selective a1 receptor antagonist 1,3-dipropyl-8-cyclopentylxantine (dpcpx) ... | 1998 | 9760134 |
| the zoonotic importance of mycobacterium tuberculosis: transmission from human to monkey. | a case of zoonotic mycobacterium tuberculosis infection in a marmoset (callithrix jacchus) is reported. genomic typing of the relevant m. tuberculosis isolates strongly suggests that the marmoset, which was kept as companion animal, acquired the disease from an infected member in the household who had been treated for pulmonary tuberculosis 8 years prior to this case. | 1998 | 9760401 |
| evaluation of the contraceptive potential of recombinant human zp3 and human zp3 peptides in a primate model: their safety and efficacy. | the unique recognition events that result in the avid binding of mammalian spermatozoa to the surface of the zona pellucida (zp) are being exploited in the development of contraceptive vaccines. in this study, the safety and efficacy of a vaccination strategy based on the induction of active immunity against purified, glycosylated, recombinant human zp3 (rhzp3) has been evaluated in a primate model, callithrix jacchus. | 1998 | 9764365 |
| interaction between rod and cone signals in responses of lateral geniculate neurons in dichromatic marmosets (callithrix jacchus). | parvocellular (p-) and magnocellular (m-) cells in the marmoset lgn can receive prominent rod input up to relatively high illuminance levels (kremers et al., 1997b). in the present paper, we quantify rod and cone input strengths under different retinal illuminance levels. the stimulus was based on the so-called "silent substitution" method. the activities of p- and m-cells of dichromatic animals were recorded extracellularly. we were able to adequately describe the response amplitudes and phases ... | 1998 | 9764535 |
| segregation of receptive field properties in the lateral geniculate nucleus of a new-world monkey, the marmoset callithrix jacchus. | the lateral geniculate nucleus (lgn) in humans and old-world monkeys is dominated by the representation of the fovea in the parvocellular (pc) layers, and most pc cells in the foveal representation have red-green cone opponent receptive field properties. it is not known whether these features are both unique to trichromatic primates. here we measured receptive field properties and the visuotopic organization of cells in the lgn of a new-world monkey, the marmoset callithrix jacchus. the marmoset ... | 1998 | 9772261 |
| diurnal variation on the excretion patterns of fecal steroids in common marmoset (callithrix jacchus) females. | the use of fecal steroid analysis to assess gonadal and adrenal function in primates has rapidly increased in recent years due to the ability to collect feces from nonhuman primates living in wild conditions. these techniques offer an exciting new potential for enhancing our knowledge of the endocrine status of free-living animals. prior to using these techniques under field conditions, it is important to determine the diurnal variation of fecal excreted steroids for assessing possible time limi ... | 1998 | 9773674 |
| artificial insemination in callithrix jacchus using fresh or cryopreserved sperm. | assisted reproductive techniques are needed urgently to facilitate the captive breeding of many new world primate species which are endangered in the wild and to assist the effective genetic management of small colonies. a protocol was devised for artificial insemination in the common marmoset, callithrix jacchus, using ejaculated sperm obtained by vaginal washing after copulation. a double insemination protocol was employed, with the first insemination taking place the day before ovulation was ... | 1998 | 9776489 |
| microsatellite primers for genotyping common marmosets (callithrix jacchus) and other callitrichids. | 1998 | 9787452 | |
| electrophoretic polymorphisms and their taxonomic implications in callitrichini (primates, platyrrhini). | five hundred forty-three blood samples from 15 populations of the four genera of callitrichin primates were studied electrophoretically. polymorphism and genetic distances were estimated for 20 loci, 13 of which were polymorphic. the lion tamarin (leontopithecus) studied here exhibited the least variability for these loci, while the monospecific cebuella showed the most. the genetic distances observed between callithrix and cebuella genera support previous evidence indicating a close taxonomic r ... | 1998 | 9791719 |
| lectin-binding patterns in the olfactory epithelium and vomeronasal organ of the common marmoset. | the patterns of expression of sugar residues in the olfactory epithelium and vomeronasal organ of the common marmoset were studied lectin-histochemically. eight lectins including dba, bsl-i, rca-i, s-wga, pna, ecl, uea-i and con a bound to the free border of the olfactory epithelium, and 6 lectins including dba, rca-i, s-wga, pna, ecl and uea-i bound to that of the vomeronasal organ. uea-i bound to all dendrites of the olfactory receptor cells, and 6 lectins including bsl-i, rca-i, s-wga, pna, e ... | 1998 | 9795901 |
| [dermal application of lisuride on parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in the common marmoset and on cases with parkinson's disease]. | dermal administration is a nonoral drug delivery system that can keep the concentration of a drug in the body at a proper level for a long time. this is suitable especially in patients in the advanced stages of parkinson's disease with a wearing-off phenomenon (short duration of effects on antiparkinsonian drugs), or in postoperative patients who cannot be treated with oral administration. we studied the effects of lisuride, a dopamine receptor agonist, in the dermal application on mptp-treated ... | 1998 | 9800199 |
| expression and immunolocalization of the oxytocin receptor in human lactating and non-lactating mammary glands. | the milk ejection reflex is mediated by the release of pituitary oxytocin and its interaction with specific receptors within the mammary gland. although up-regulation of the oxytocin receptor during lactation has been shown for the rat mammary gland by ligand binding assay, investigation of the receptor expression in human breast at the molecular level has not yet been carried out in detail. here we report the expression and immunolocalization of the oxytocin receptor in the human breast. it app ... | 1998 | 9806301 |
| assessment of cage use by laboratory-bred common marmosets (callithrix jacchus). | the way in which breeding families of laboratory-born marmosets used the space provided by their cages, and a small protruding 'veranda', was assessed in order to determine the popularity of the veranda as a form of environmental enrichment, and the extent to which the marmosets confined themselves to only part of the cage. the veranda was found to be of enduring interest to the marmosets whose occupancy of this space was an order of magnitude greater than the rest of the cage. the upper part of ... | 1998 | 9807756 |
| pharmacologically evoked fictive motor patterns in the acutely spinalized marmoset monkey (callithrix jacchus). | the existence of a spinal network capable of generating rhythmic alternating activity resembling locomotion still has not been firmly established in primates, including man, although evidence for one is accumulating. the present study investigated whether it is possible to activate such a network by administration of a variety of pharmacological agents to acutely spinalized marmoset monkeys (callithrix jacchus) in the absence of phasic afferent input to the spinal cord. fourteen marmoset monkeys ... | 1998 | 9808308 |
| [experimental in vivo passage of h2 strain of live attenuated vaccine of hepatitis a in common marmosets]. | common marmosets with negative serum antibodies against hepatitis a virus (anti-hav) and normal liver functions were used for the tests of passage of h2 vaccine strain of hav to explore its residual virulence after attenuation and possibility of its reversion. common marmosets were inoculated with attenuated live vaccine, and fecal suspension and/or proliferative liquid in tissue culture of the progeny of vaccine hav excreted from their feces were passaged in common marmosets. result of three se ... | 1997 | 9812599 |
| adaptations to subordinate status in female marmoset monkeys. | in singular cooperatively breeding mammals, social status is a key determinant of female reproductive success. usually only one dominant female breeds in a social group. in the common marmoset (callithrix jacchus), a cooperatively breeding primate, adaptations to nonbreeding subordinate status appear to parallel those found in social insect societies which demonstrate similar skew to the marmoset in female reproductive success. female marmosets exhibit rank-related polyethism in behavior, reprod ... | 1998 | 9826999 |
| parthenogenetic activation of marmoset (callithrix jacchus) oocytes and the development of marmoset parthenogenones in vitro and in vivo. | mammalian oocytes can be induced to resume meiosis without fertilization, and the resulting parthenogenetic embryos carry only maternal chromosomes. human oocytes can be activated by many chemical and physical stimuli, but postimplantation studies of human parthenogenetic embryos are not ethically acceptable. the common marmoset monkey (callithrix jacchus) is a good model for studying primate parthenogenetic development postimplantation, since follicular aspiration, embryo transfer, and early po ... | 1998 | 9828197 |
| behavioral discrimination between circumgenital odor from peri-ovulatory dominant and anovulatory female common marmosets (callithrix jacchus). | social peer groups of callitrichid monkeys [marmosets and tamarins] exhibit intrasexual dominance hierarchies in captivity. this laboratory study employed two-choice behavioral discrimination bioassys to test the hypothesis that scent from female common marmosets contains chemical cues that permit discrimination between dominant females in the periovulatory versus luteal phase of the ovarian cycle and females holding dominant versus subordinate status. when scent from only dominant females was p ... | 1998 | 9839902 |
| identification of evolutionarily invariant sequences in the protein c gene promoter. | recent studies on human protein c gene expression have revealed the presence of three transcription factor binding sites in close proximity to the transcription start site. binding sites for the liver-enriched hepatocyte nuclear factors 1 and 3 (hnf-1 and hnf-3, respectively) are located immediately upstream of the transcription start site, whereas just downstream of the start site a presently unidentified transcription factor may bind. to identify other candidate transcription factor binding si ... | 1998 | 9847407 |
| lateralized use of the mouth in production of vocalizations by marmosets. | we have found that the common marmoset, callithrix jacchus, displays a larger left hemimouth during production of fear expressions, with or without vocalization, and a larger right hemimouth when producing a social contact call. thus, marmosets have right hemisphere specialization for the production of negative emotional expressions and vocalizations and left hemisphere specialization for the production of social contact communication. these hemispheric specializations for social communication i ... | 1998 | 9863680 |
| perseveration and strategy in a novel spatial self-ordered sequencing task for nonhuman primates: effects of excitotoxic lesions and dopamine depletions of the prefrontal cortex. | damage to the prefrontal cortex disrupts the performance of self-ordered sequencing tasks, although the precise mechanisms by which this effect occurs is unclear. active working memory, inhibitory control, and the ability to generate and perform a sequence of responses are all putative cognitive abilities that may be responsible for the impaired performance that results from disruption of prefrontal processing. in addition, the neurochemical substrates underlying prefrontal cognitive function ar ... | 1998 | 9869708 |
| pharmacological characterisation of dopamine overflow in the striatum of the normal and mptp-treated common marmoset, studied in vivo using fast cyclic voltammetry, nomifensine and sulpiride. | the in vivo measurement of electrically-evoked dopamine overflow was measured for the first time in the striatum of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets using fast cyclic voltammetry at untreated carbon-fibre microelectrodes, (7 microm, o.d.). the identity of dopamine was confirmed using electrochemical, pharmacological and histological criteria and complied with rat data from earlier studies. dopamine overflow depended on the intensity, number of pul ... | 1998 | 9874156 |
| ubiquitin and apoptosis in the corpus luteum of the marmoset monkey (callithrix jacchus). | the polypeptide ubiquitin covalently binds to cytoplasmic proteins and marks them for proteolytic degradation. ubiquitin is upregulated during apoptosis in some systems. apoptosis increases during luteolysis but it is not known whether ubiquitin is expressed in regressing corpora lutea. marmoset ovaries were removed on day 10 of the luteal phase from animals that had received either no treatment, treatment with the pgf2 alpha analogue cloprostenol 24 h earlier, or treatment with the gnrh antagon ... | 1998 | 9875169 |
| polygyny and infanticide in common marmosets in a fragment of the atlantic forest of brazil. | 1998 | 9885340 | |
| prion protein immunohistochemical staining in the brains of monkeys with transmissible spongiform encephalopathy. | prion protein (prp) immunohistochemical staining of the brains of common marmosets (callithrix jacchus) with experimental transmissible spongiform encephalopathy is described. the monkeys (n = 17) had been injected, intracerebrally, 17-49 months previously with homogenates of brain tissue taken post mortem from a cow with bse (n = 2 monkeys), a sheep with natural scrapie (n = 2 monkeys), human cases of growth hormone related creutzfeldt-jakob disease (cjd) (n = 2 monkeys), sporadic cjd (n = 5 mo ... | 1998 | 9888158 |
| differential splicing and expression of the relaxin-like factor gene in reproductive tissues of the marmoset monkey (callithrix jacchus). | the relaxin-like factor (rlf) is a novel member of the insulin/relaxin/insulin-like growth factor family of growth factors and hormones that is expressed predominantly in the reproductive system, with highest expression in the leydig cells of the testis. using a combination of molecular and immunological techniques, we have characterized the structure and expression of the rlf gene from a primate model, the marmoset monkey, with the intention of comparing this with recent results on the closely ... | 1999 | 9916013 |
| a comparison of rectal and subcutaneous body temperature measurement in the common marmoset. | two methods of measuring body temperature were compared in common marmosets. subcutaneous temperatures were measured remotely via previously implanted subcutaneous microchips (plexx bv, iptt-100) prior to measurement of rectal temperature using a conventional rectal probe. marmosets were treated with saline or the brain penetrant, 5-ht1a/b/d receptor agonist skf-99101h (3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate) (0.3-3 mg/kg sc), which has previously been shown to induce hyp ... | 1998 | 9920530 |
| behavioral and single chorda tympani taste fiber responses in the common marmoset, callithrix jacchus jacchus. | gustatory responses of the common marmoset were studied using single fiber recordings from chorda tympani (ct) nerve and two bottle preference (tbp) tests. hierarchical cluster analysis of 43 fibers' response profiles revealed 3 major clusters of fibers characterized by predominant sensitivity to sweeteners (s cluster), bitter compounds (q cluster) or acids (h cluster). nacl as well as licl did not stimulate ct taste fibers. the tbp tests showed relationship between a compound's ability to stimu ... | 1998 | 9929598 |
| determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis. | definition of the immune process that causes demyelination in multiple sclerosis is essential to determine the feasibility of ag-directed immunotherapy. using the nonhuman primate, callithrix jacchus jacchus (common marmoset), we show that immunization with myelin basic protein and proteolipid protein determinants results in clinical disease with significant demyelination. demyelination was associated with spreading to myelin oligodendrocyte glycoprotein (mog) determinants that generated anti-mo ... | 1999 | 9973519 |
| effect of selegiline on dopamine concentration in the striatum of a primate. | monoamine oxidase (mao) has two subtypes, a and b, that have different distributions between the rodent and the human. in the striatum, dopamine (da) of the rat seems to be metabolized by mao a, and da of the human is largely deaminated by mao b. mao in the striatum of common marmosets is also type b. using in vivo microdialysis, we investigated the pharmacological activity of selegiline, a selective irreversible inhibitor of mao b, in the striatum of marmosets. intraperitoneal co-administration ... | 1999 | 9974121 |
| effects of the new angiotensin ii type 1 receptor antagonist krh-594 on several types of experimental hypertension. | the antihypertensive effect of dipotassium (z)-2-[[5-ethyl-3-[2'-(1h- tetrazol-5-yl)biphenyl-4-yl]methyl-1,3,4-thiadiazoline-2- ylidene]aminocarbonyl]-1-cyclopentenecarboxylate (cas 169328-25-0, krh-594), a new angiotensin ii type 1 (at1) receptor antagonist, was studied in several experimental hypertensive models. the effects of krh-594 on the circulating reninangiotensin system and on renal function were also investigated. oral administration of krh-594 (0.3 or 1 mg/kg) dose-dependently inhibi ... | 1999 | 10028373 |
| blockade of the hypothalamic-pituitary-testicular axis with a gnrh antagonist in the neonatal marmoset monkey: changes in leydig cell ultrastructure. | little is known of the cell biology of leydig cells during the neonatal activation of the hypothalamic-pituitary-testicular (hpt) axis. the current study examined the effect of blockade of the hpt axis with a gnrh antagonist (antide) on the neonatal population of leydig cells in the new world primate, the common marmoset. three sets of twins, age 7 weeks, were studied: in each pair one twin was used as a control, while the other received treatment with gnrh antagonist from the day of birth to su ... | 1998 | 10036790 |
| cross-fostering between two species of marmosets (callithrix jacchus) and callithrix penicillata). | cross-fostering technique can be defined as adoption of infants by adults of other species. this phenomenon is poorly investigated because very young animals have few opportunities to interact peacefully with non-conspecific adults, either in captivity or in natural conditions. this study describes the induction of cross-fostering in captivity between white tufted-ear (callithrix jacchus) and black tufted-ear marmosets (callithrix penicillata). we conclude that this technique can be very useful ... | 1998 | 10049101 |
| litter size does not interfere with fertility in common marmosets, callithrix jacchus. | 2006 | 10050067 | |
| anatomical structure and surface epithelial distribution in the nasal cavity of the common cotton-eared marmoset (callithrix jacchus). | to validate use of the common cotton-eared marmoset (callithrix jacchus) in inhalation toxicity studies, its nasal morphology was examined. the nasal turbinates each consisted of one maxilloturbinate and one ethmoturbinate: these were more planar in structure than the comparable structures of rodents or dogs. the nasal cavity epithelia comprised squamous epithelium (se), nasal transitional epithelium (nte), respiratory epithelium (re) and olfactory epithelium (oe), listed in order of occurrence ... | 1999 | 10067203 |
| energy intake during reproduction in captive common marmosets (callithrix jacchus). | among haplorhine primates, the highly specialized callitrichidae (marmosets and tamarins) are expected to have comparatively high reproductive costs, a feature that might be related to the evolution of a cooperative breeding system. costs of reproduction in captivity were investigated on the basis of changes in energy intake and body weight during pregnancy and lactation in pair-living female and male common marmosets (callithrix jacchus). the experimental design had little effect on carrying be ... | 2006 | 10073491 |
| effects of separation and novelty on distress vocalizations and cortisol in the common marmoset (callithrix jacchus). | in socially-bonding species, separation from familiar attachment figures is widely known to stimulate a physiological and behavioral stress response. this study investigated the hormonal and vocal responses of adult common marmosets to separation from familiar group members and to 24 hr of cohabitation with an unfamiliar opposite-sex conspecific. all subjects were removed from their home cages and placed into a novel environment for 20 min. in one group, marmosets were exposed to an unfamiliar, ... | 1999 | 10075435 |
| the influence of abiotic factors on the onset and cessation of activity of semi-free callithrix jacchus. | the influence of abiotic environmental factors on the period of activity of a single group of south american common marmosets (callithrix jacchus, callitrichidae, primates) was investigated under semi-free conditions. a group of eight members had a territory consisting of a heated wooden hut with a veranda, surrounded by an open area with a few trees (ca. 3.5 m high) and three runways made out of roofing slats, on which feeding places and sleeping boxes were fixed. the food supply was held const ... | 1999 | 10075438 |
| ingestion of calcium solutions by common marmosets (callithrix jacchus). | callithrix jacchus, the common marmoset, is a small new world primate that feeds on insects, fruit, and gum, and has a high reproductive rate for a primate. insects are generally a poor source of dietary calcium, while gums may contain significant levels of calcium. their high reproductive rate also suggests that reproductive female c. jacchus might be susceptible to calcium deficiency. thus, we hypothesized that common marmosets might find solutions containing calcium to be palatable. we used c ... | 1999 | 10075439 |
| age-related changes in the brainstem auditory evoked potentials of the marmoset. | changes in brain-stem auditory evoked potentials (baeps) with age were recorded in common marmosets (callithrix jacchus) at the age of 1-2, 6-8 and 10-12 years. the auditory function was assessed by thresholds, latencies and amplitudes of baeps evoked by use of tone burst stimulations with audible frequencies ranging from 1 to 99 khz. prolongation of the latencies of later waves was observed in the animals at the age of 6-8 and 10-12 years at high frequencies, suggesting that aging in marmosets, ... | 1999 | 10082292 |
| growth variation in common marmoset monkeys (callithrix jacchus) fed a purified diet: relation to care-giving and weaning behaviors. | significant relations were observed between select infant-care and weaning behaviors and growth in body weight in common marmoset monkeys (callithrix jacchus). the patterns of these relations suggest that earlier occurrence of developmental milestones, such as cessation of transport (being off carriers) and weaning to solid food, were associated with slower growth during the subsequent period. in contrast, more frequent nursing bouts during the period in which weaning was initiated were associat ... | 1998 | 10090026 |
| new hyperprolactinemia and anovulation model in common marmoset (callithrix jacchus) and effect of cabergoline. | we aimed to develop an anovulation model, using sulpiride-induced hyperprolactinemia in common marmosets. the serum prolactin level gradually increased during the twice-daily administration of sulpiride and reached a plateau after 4 days. sulpiride produced as big a response at 10 mg kg(-1) as at 50 mg kg(-1). in this study, the length of the ovarian cycle was approximately 30 days in normal common marmosets. serum progesterone and estradiol levels showed no consistent change during the first 2 ... | 1999 | 10096770 |
| analysis of the short wavelength-sensitive ("blue") cone mosaic in the primate retina: comparison of new world and old world monkeys. | the distribution of short wavelength-sensitive (sws or "blue") cone photoreceptors was compared in primates with dichromatic ("red-green colour blind") and trichromatic colour vision. we compared a new world species, the marmoset (callithrix jacchus), with an old world species, the macaque monkey (macaca nemestrina). the sws cones were identified by their immunoreactivity to an antiserum against the human sws cone opsin. a single retina from a male capuchin monkey (cebus apella) also was studied ... | 1999 | 10100889 |
| actions of the d1 agonists a-77636 and a-86929 on locomotion and dyskinesia in mptp-treated l-dopa-primed common marmosets. | common marmosets show parkinsonian motor deficits following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) administration and develop dyskinesias during chronic l-dopa exposure. the d1 agonists a-77636 [(1r, 3s) 3-(1'-adamantyl)-1-aminomethyl-3, 4-dihydro-5, 6-dihydroxy-1h-2-benzopyran hcl] and a-86929 [(-)-trans 9, 10-hydroxy-2-propyl-4, 5, 5a, 6, 7, 11b-hexahydro-3-thia-5-azacyclopent-1-ena[c]phenanthrene hydrochloride] possess potent antiparkinsonian activity in the mptp-treated marmoset ... | 1999 | 10102782 |
| role of cellular tumor necrosis factor receptor-associated factors in nf-kappab activation and lymphocyte transformation by herpesvirus saimiri stp. | the stp oncoproteins of the herpesvirus saimiri (hvs) subgroup a strain 11 and subgroup c strain 488 are now found to be stably associated with tumor necrosis factor receptor-associated factor (traf) 1, 2, or 3. mutational analyses identified residues of pxqxt/s in stp-a11 as critical for traf association. in addition, a somewhat divergent region of stp-c488 is critical for traf association. mutational analysis also revealed that stp-c488 induced nf-kappab activation that was correlated with its ... | 1999 | 10196286 |
| intestinal cryptococcosis in a common marmoset (callithrix jacchus). | a five-year-old female common marmoset (callithrix jacchus) died after a one-month clinical course of nonspecific signs. pathologic findings were acute diffuse fibrinonecrotizing enteritis and granulomatous endolymphangitis of intestinal and mesenteric lymphatic vessels. both lesions were associated with a marked proliferation of mayer's mucicarmine-positive, 4 to 15 microm yeasts that were surrounded by a wide clear halo. the infection was probably acquired by oral route. other findings include ... | 1998 | 10203010 |
| gastrointestinal tumors observed in nonhuman primates at the german primate center. | twenty-six gastrointestinal tumors were observed in twenty-three nonhuman primates during routine necropsies at the german primate center, göttingen. the majority (15 cases) were colorectal mucoid adenocarcinomas in cotton-top tamarins (saguinus oedipus), which in two animals were associated with gastric adenomas. three cases of small intestinal mucoid adenocarcinomas occurred in common marmosets (callithrix jacchus). one colonic leiomyoma was observed in a dwarf galago (galagoides demidovii) an ... | 1998 | 10203013 |
| the common marmoset as a target preclinical primate model for cytokine and gene therapy studies. | nonhuman primate models are useful to evaluate the safety and efficacy of new therapeutic modalities, including gene therapy, before the inititation of clinical trials in humans. with the aim of establishing safe and effective approaches to therapeutic gene transfer, we have been focusing on a small new world monkey, the common marmoset, as a target preclinical model. this animal is relatively inexpensive and easy to breed in limited space. first, we characterized marmoset blood and bone marrow ... | 1999 | 10216078 |
| effect of ambient temperature on the circadian activity rhythm in common marmosets, callithrix j. jacchus (primates). | whereas the (zeitgeber) effect of ambient temperature ta and temperature cycles tac's on circadian rhythmicity has been well documented for heterothermic mammals, inconsistent results have been obtained for strictly homeothermic species. hence, it might be inferred that the susceptibility of the mammalian circadian timing system (cts) to ta and tac's depends on the range of the animals' core and/or brain temperature rhythm. this hypothesis was tested in the common marmoset (callithrix j. jacchus ... | 1999 | 10219487 |
| genetically engineered mengo virus vaccination of multiple captive wildlife species. | encephalomyocarditis virus (emcv), has caused the deaths of many species of animals in zoological parks and research institutions. the audubon park zoo, (new orleans, louisiana, usa) attempted vaccination of several species with a killed emcv vaccine with mixed results. this paper reports an attempt at vaccination against emcv using a genetically engineered, live attenuated mengo virus (vmc0) at the audubon park zoo and miami metro zoo, (miami, florida, usa) from december 1996 to june 1997. seve ... | 1999 | 10231768 |
| major histocompatibility complex class ii polymorphisms in primates. | in the past decade, the major histocompatibility complex (mhc) class ii region of several primate species has been investigated extensively. here we will discuss the similarities and differences found in the mhc class ii repertoires of primate species including humans, chimpanzees, rhesus macaques, cotton-top tamarins and common marmosets. such types of comparisons shed light on the evolutionary stability of mhc class ii alleles, lineages and loci as well as on the evolutionary origin and biolog ... | 1999 | 10319272 |
| design and evaluation of a zp3 peptide vaccine in a homologous primate model. | the concept of a safe, immunocontraceptive vaccine using the zona pellucida glycoprotein 3 (zp3) as an immunogen has been marred by the appearance of ovarian dysfunction in several species. however, careful selection of epitopes on mouse zp3 have demonstrated that it is possible to segregate contraceptive bone marrow-derived (b)-cell epitopes from the cytotoxic thymus-derived (t)-cell epitopes thought to be responsible for inducing ovarian disease. b-cell epitopes on marmoset zp3 (mstzp3) were i ... | 1999 | 10321806 |
| normal development of refractive state and ocular component dimensions in the marmoset (callithrix jacchus). | refractive state and ocular dimensions were studied longitudinally in nine normal marmosets. animals were anaesthetised and examined (with some exceptions) at 4, 6, 7, 8, 10, 15, 24 and 39 weeks of age. cycloplegic retinoscopy showed that hyperopia early in life rapidly diminished. refraction corrected for the artefact of retinoscopy stabilised by 8 weeks of age, but at a slightly myopic value, rather than at emmetropia. the ocular components continued to change throughout the period studied. co ... | 1999 | 10326129 |
| the effects of spectacle wear in infancy on eye growth and refractive error in the marmoset (callithrix jacchus). | we made a comprehensive study, involving observations on 45 marmosets, of the effects on ocular growth and refraction of wearing spectacles from the ages of 4-8 weeks. this period was within the period early in life when the eye grows rapidly and refraction changes from hyperopia to its adult value of modest myopia. in one series of experiments we studied the effect of lenses of powers -8, -4, +4 and +8d fitted monocularly. in another series of experiments we studied the effect of lenses of equa ... | 1999 | 10326130 |
| model for the fetal recruitment of simian gamma-globin genes based on findings from two new world monkeys cebus apella and callithrix jacchus (platyrrhini, primates). | the originally embryonic gamma-globin locus duplicated and acquired a novel (fetal) pattern of expression in a defined time period (55-40 million years ago) during primate phylogeny. the objective of this study was to determine some of the factors that led to first the emergence of fetal gamma specificity and then the maintenance of different fetal gamma expression patterns in extant simian primates (e.g., human, capuchin monkey). analyses focused on two platyrrhine (new world monkey) species: t ... | 1999 | 10327648 |
| direct effects of the prostaglandins e2 and f2alpha on progesterone release by the corpus luteum of the marmoset monkey (callithrix jacchus) studied by in vitro microdialysis. | the effects of the prostaglandins (pg) e2 and f2alpha on progesterone secretion in luteal tissue (32 corpora lutea) explanted from the mid-luteal ovary of the marmoset monkey (n=13) were investigated using an in vitro microdialysis system. consecutive applications of 1, 10 and 100 microg/ml pge2 resulted in a significant increase in secretion of progesterone at the maximum dose of 100 microg/ml, which was shown to be the stimulatory dose in both long-period and 20-min pulse (time to collect one ... | 1999 | 10333546 |
| temporal contrast sensitivity in the lateral geniculate nucleus of a new world monkey, the marmoset callithrix jacchus. | 1. the temporal contrast sensitivity of koniocellular, parvocellular and magnocellular cells in the lateral geniculate nucleus (lgn) of nine adult marmosets was measured. the receptive fields of the cells were between 0.3 and 70 deg from the fovea. the stimulus was a large spatially uniform field which was modulated in luminance at temporal frequencies between 0.98 and 64 hz. 2. for each cell group there was a gradual increase in modulation sensitivity, especially for temporal frequencies below ... | 1999 | 10358129 |
| ganglion cells of a short-wavelength-sensitive cone pathway in new world monkeys: morphology and physiology. | we have studied the morphology and physiology of retinal ganglion cells of a short-wavelength-sensitive cone (sws-cone) pathway in dichromatic and trichromatic new world anthropoids, the capuchin monkey (cebus apella) and tufted-ear marmoset (callithrix jacchus). in old world anthropoids, in which males and females are both trichromats, blue-on/yellow-off retinal ganglion cells have excitatory sws-cone and inhibitory middle- and long-wavelength-sensitive (mws- and lws-) cone inputs, and have bee ... | 1999 | 10367967 |
| the dopamine d3/d2 receptor agonist 7-oh-dpat induces cognitive impairment in the marmoset. | previous work has shown that dopaminergic systems are involved in cognitive function in the common marmoset. the present study investigated the role of dopamine d3 receptors in cognitive performance in the marmoset. the effects of the putative dopamine d3 receptor agonist, 7-oh-dpat, on performance of a same-day reversal visual object discrimination task were assessed using a miniature wisconsin general test apparatus (wgta). within the same test session marmosets acquired a two-choice object di ... | 1999 | 10371648 |
| efficacy and effects of short- and medium-term contraception in the common marmoset (callithrix jacchus) using melengestrol acetate implants. | this study examines the effect of melengestrol acetate (mga) implants on reproductive function and various biochemical parameters, ovarian activity, and uterine morphology in ten female common marmosets implanted for either 6-8 or 19-21 months. measures of body weight, concentrations of urinary glucose and blood liver enzymes were taken. ovarian activity was assessed by analysis of urinary progestin levels and ultrasound examinations of the ovaries. ultrasonography was also used to evaluate uter ... | 1999 | 10372539 |
| leukocyte differential analysis in multiple laboratory species by a laser multi-angle polarized light scattering separation method. | leukocyte differential analysis was performed in various species, particularly laboratory animals, by the laser multi-angle polarized light scattering separation method. venous blood specimens were drawn from the following subjects: healthy adult men and women ("humans"); cynomolgus monkeys ("monkeys"); common marmosets ("marmosets"); beagle dogs ("dogs"); miniature potbelly pigs ("swine"); japanese white rabbits ("rabbits"); hartley guinea pigs ("guinea pigs"); and sprague-dawley rats ("rats"). ... | 1999 | 10374072 |
| tgf-beta could be involved in paracrine actions in the epididymis of the marmoset monkey (callithrix jacchus). | the transforming growth factor-beta1 (tgf-beta1) and the transforming growth factor-beta receptor type ii (tgf-betarii) were studied in the epididymis of sexually mature marmoset monkeys (callithrix jacchus) by immunohistochemical localization of the protein and by polymerase chain reaction (pcr) analysis of the mrna level. in order to specify reactive cell types, the morphology of all three segments (caput, corpus, and cauda epididymidis) was evaluated by light microscopy. six different cell ty ... | 1999 | 10386817 |
| sexual behavior and extragroup copulations in a wild population of common marmosets (callithrix jacchus). | sexual behavior and mating patterns are described for 3 free-ranging groups of common marmosets living in a coastal forest in northeastern brazil. each group contained 2 breeding females. within groups, sexual behavior was generally restricted to breeding females and a single behaviorally dominant male. of 101 mounts and copulations, 24 involved pairings of individuals from 2 different groups. extragroup sexual behavior was performed by both breeding and nonbreeding group members, and 65% of all ... | 1999 | 10394062 |
| the mother's participation in infant carrying in captive groups of leontopithecus chrysomelas and callithrix jacchus. | callithrix and leontopithecus exhibit ecological differences that have implications for the patterns of infant care. in c. jacchus, which uses a small home range because it depends mainly on plant exudates, infants can forage independently early in their life. l. chrysomelas, which feeds mainly on fruits and insects, needs larger home ranges and, therefore, its infants have a more extensive period of dependence. three families of c. jacchus and four families of l. chrysomelas were studied in cap ... | 1999 | 10394063 |
| metabolism of adenosine increase in the striatum in common marmoset parkinsonism induced by mptp. | 1999 | 10410711 | |
| relaxin in the marmoset monkey: secretion pattern in the ovarian cycle and early pregnancy. | relaxin is a peptide hormone with a broad range of biological activities, related not only to parturition and lactation but possibly also to decidualization, implantation, and early pregnancy. the present study was designed to investigate the secretion pattern of relaxin throughout the cycle and early pregnancy in the common marmoset monkey in relation to ovarian function and the systemic hormone milieu. first, a novel relaxin elisa was developed and validated to confirm the pattern of relaxin s ... | 1999 | 10411534 |
| unrearable litters and prenatal reduction of litter size in the common marmoset (callithrix jacchus). | it is widely believed that common marmosets (callithrx jacchus) typically give birth to twins under natural conditions. in captivity, however, births of triplets or even larger litters are common, although parents rarely succeed in rearing more than two offspring. the traditional interpretation is that captive conditions, notably the ready availability of food, have led to increased reproductive output, perhaps involving a higher ovulation rate. the present paper provides evidence, combined from ... | 1999 | 10431697 |
| analysis of two types of cone bipolar cells in the retina of a new world monkey, the marmoset, callithrix jacchus. | two types of cone bipolar cells, the blue cone bipolar cell and the diffuse bipolar cell (db3), were labelled immunohistochemically and investigated in the retina of a new world monkey, the marmoset. blue cone bipolar cells were labelled with an antiserum against cholecystokinin. short-wavelength-sensitive (sws) cones were labelled with an antiserum against the sws cone opsin. the db3 cells were labelled with antibodies to calbindin. blue cone bipolar cells in marmoset do not form a regular mosa ... | 1999 | 10431919 |
| serial mr imaging of experimental autoimmune encephalomyelitis induced by human white matter or by chimeric myelin-basic and proteolipid protein in the common marmoset. | experimental autoimmune encephalomyelitis (eae) in the marmoset was monitored by serial mr imaging to determine correlates to the natural-history mr studies in multiple sclerosis (ms). the relationships of mr-revealed lesions to clinical status and histopathologic findings were also explored. | 1999 | 10445431 |
| food avoidance learning in squirrel monkeys and common marmosets. | using a conditioned food avoidance learning paradigm, six squirrel monkeys (saimiri sciureus) and six common marmosets (callithrix jacchus) were tested for their ability to (1) reliably form associations between visual or olfactory cues of a potential food and its palatability and (2) remember such associations over prolonged periods of time. we found (1) that at the group level both species showed one-trial learning with the visual cues color and shape, whereas only the marmosets were able to d ... | 1998 | 10454364 |
| unipolar brush cells in the cochlear nuclei of a primate (callithrix jacchus). | unipolar brush cells (ubcs) have been recognized in the cerebella of many species including primates. they have also been identified in the cochlear nuclei (cn) of many mammals, however, not in any primate. our immunohistochemical study in the marmoset demonstrates the presence of abundant calretinin immunoreactive (cr-ir) ubcs in the cerebellum, as in other mammals. in the marmoset cn, in contrast, cr-ir ubcs could hardly be identified. the reverse pattern was evident in sections immunostained ... | 1999 | 10462114 |
| increase in urinary excretion of 6beta-hydroxycortisol in common marmosets as a marker of hepatic cyp3a induction. | the ratio of urinary 6beta-hydroxycortisol (6beta-ohf) to free cortisol (f), i.e., the 6beta-ohf/f ratio, has been reported to be a specific marker for human cyp3a induction by in vivo studies of human subjects. in the development of drugs, it is quite beneficial to predict human cyp3a induction in preclinical safety studies using urine samples from experimental animals. we examined the 6beta-ohf/f ratio in urine of common marmosets administered with rifampicin, a potent inducer of cyp3a, to eva ... | 1999 | 10463384 |
| context and sex differences exist in the acoustic structure of phee calls by newly-paired common marmosets (callithrix jacchus). | captive common marmosets of all ages robustly produce a "separation" phee call during brief separations from their group. in contrast, a second structural variant, which may function as an intergroup call, is produced in the home cage primarily by the reproductive adults. a previous study found that postpubertal but nonreproductive offspring rarely produce phee calls when in the home cage with the natal group, yet these marmosets call frequently after pairing with an opposite-sex partner. the su ... | 1999 | 10466575 |
| the effects of acutely administered low dose sarin on cognitive behaviour and the electroencephalogram in the common marmoset. | previous studies have suggested that administration of a clinically sign-free dose of sarin to non-human primates gives rise to subtle changes in brain electrical activity as measured by electroencephalography (eeg) several months following exposure. the functional significances of such changes are unclear. the present study monitored eeg by using implantable radiotelemetry, and also assessed the performance of complex behavioural tasks, in non-human primates for up to 15 months following exposu ... | 1999 | 10475717 |
| social determinants of reproductive failure in male common marmosets housed with their natal family. | postpubertal male common marmosets, callithrix jacchus, engage in little or no sexual behaviour while living with their natal families. the social mechanisms underlying this phenomenon have not been identified but have been assumed to include reproductive suppression by dominant males and/or avoidance of mating with closely related females. we evaluated these two possible components of male reproductive failure. seven postpubertal males and their fathers underwent a series of 45-min sex tests, i ... | 1999 | 10479365 |
| new world, but not old world, monkeys carry several genes encoding beta-microseminoprotein. | it was shown by southern hybridization that cotton-top tamarin and common marmoset, new world monkeys, carry three or more genes encoding beta-microseminoprotein, also known as psp94. in contrast, the genomes of old world monkeys, as represented by rhesus macaque and sacred baboon, contain a single gene. clones containing three different genes encoding beta-microseminoprotein were isolated from a cotton-top tamarin genomic library. they carry two complete genes of four exons and a third gene lac ... | 1999 | 10491085 |
| synaptic input to small bistratified (blue-on) ganglion cells in the retina of a new world monkey, the marmoset callithrix jacchus. | small bistratified (blue-on) ganglion cells in the primate retina are involved in processing short wavelength sensitive cone signals. these ganglion cells stratify in both the on- and off-sublamina of the inner plexiform layer. we investigated the origin of synaptic input to the small bistratified ganglion cell in the retina of a new world primate, the marmoset callithrix jacchus. two small bistratified cells from peripheral retina were intracellularly filled with lucifer yellow, subsequently ph ... | 1999 | 10502249 |
| cutaneous receptive field organization in the ventral posterior nucleus of the thalamus in the common marmoset. | the organization of cutaneous receptive fields in the ventroposterior (vp) thalamus of the common marmosets (callithrix jacchus) was determined from single-unit recordings, and these data were correlated with the cytochrome oxidase (co) histochemistry of the thalamus in the same animals. under continuously maintained ketamine anesthesia, the receptive fields of a total of 192 single units were recorded from the right vp thalamus using 2 mohms glass electrodes. after the receptive fields were map ... | 1999 | 10515975 |
| a reinke-like inclusion within leydig cells of the marmoset monkey (callithrix jacchus) | 1999 | 10529068 | |
| retinohypothalamic projections in the common marmoset (callithrix jacchus): a study using cholera toxin subunit b. | retinal projections in vertebrates reach the primary visual, accessory optic, and circadian timing structures. the central feature of the circadian timing system is the principal circadian pacemaker, the suprachiasmatic nucleus (scn) of the hypothalamus. the direct projections from the retina to the scn are considered the entrainment pathway of the circadian timing system. in this study, unilateral intravitreal injections of cholera toxin subunit b were used to trace the retinal projections to t ... | 1999 | 10553121 |
| in vivo models for epstein-barr virus (ebv)-associated b cell lymphoproliferative disease (blpd). | ebv infects b lymphocytes in vivo and establishes a life-long persistent infection in the host. the latent infection is controlled by ebv-specific mhc class 1-restricted ctl. immunosuppression reduces ctl activity, and this facilitates outgrowth of ebv+ve b cell lymphoproliferative disease (blpd). blpd are aggressive lesions with high mortality. this review presents some key facets in the development of ebv-associated blpd and in vivo studies on its pathogenesis. the animal models used to date i ... | 1999 | 10578121 |
| primary ca1 and conditionally immortal mhp36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal ca1 field. | common marmosets (callithrix jacchus, n = 18) were trained to discriminate between rewarded and non-rewarded objects (simple discriminations, sds) and to make conditional discriminations (cds) when presented sequentially with two different pairs of identical objects signifying reward either in the right or left food well of the wisconsin general test apparatus. after bilateral n-methyl-d-aspartate (0.12 m) lesions through the cornu ammonis-1 (ca1) field (7 microl in five sites), marmosets showed ... | 1999 | 10581225 |
| effects of beta-blockers and nicardipine on oxotremorine-induced tremor in common marmosets. | effects of beta-blockers (propranolol, arotinolol and nipradilol) and a ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets. generalized tremor was elicited by an intraperitoneal administration of 0.25 mg/kg oxotremorine. intensity of the tremor was classified into 7 degrees, and it was evaluated every 10 min. the total intensity of oxotremorine-induced tremor for each drug was expressed as "points", which were the sum of tremor intensity scores eva ... | 1999 | 10591485 |
| expression of the integrin subunits alpha 5, alpha 6 and beta 1 in the testes of the common marmoset. | integrin subunits alpha 5, alpha 6 and beta 1 were localized in the testis of pre-pubertal or adult non-human primates (callithrix jacchus) by immunofluorescence staining and in situ hybridization. in animals of all ages subunits alpha 5 and beta 1 were localized in cells of the lamina propria of the seminiferous epithelium. in prepubertal animals, the integrin subunits alpha 5, alpha 6, as well as beta 1, were distributed all over the plasma membrane of sertoli cells. in adult animals the integ ... | 1999 | 10624606 |
| expression of adhesion receptors on rat limb bud cells and results of treatment with a thalidomide derivative. | the expression of several adhesion surface receptors was studied on cells of early limb bud development of 58 wistar rats treated orally with two daily doses of the thalidomide derivative em12 (2 x 50 mg/kg body weight) from day 7 to 10 of pregnancy. em12 is a more potent teratogen than thalidomide. limb bud cells of 56 untreated animals served as controls. the studies revealed that the integrins cd11a, cd11b, cd18, cd49d, and cd61, as well as the additional adhesion receptors cd54, cd62l, and t ... | 2000 | 10666009 |
| hormones associated with non-maternal infant care: a review of mammalian and avian studies. | hormonal changes during non-maternal infant care have been demonstrated in many cooperatively breeding bird species, some monogamous rodents and two species of new world primates. coevolution of hormones and social traits may have provided for the different breeding systems that occur today. several hormones have been shown to covary with the breeding systems of vertebrates. elevated levels of the hormone prolactin with male parenting behaviours are common to many birds, rodents and the callitri ... | 2000 | 10686483 |
| prolactin levels of fathers and helpers related to alloparental care in common marmosets, callithrix jacchus. | previous studies have suggested that prolactin may play a role in regulating allocare behaviour in cotton-top tamarins, saguinus oedipus. in this study, we investigate the prolactin profile of 3 groups of captive common marmosets, callithrix jacchus. carrying behaviour in this species was observed after parturition. prolactin assays of blood samples of both fathers and helpers (sub-adult non-fathers) in 3 family groups were taken for 8 weeks before and after birth of the infants. the after-birth ... | 2006 | 10686484 |
| motor effects of (-)-osu6162 in primates with unilateral 6-hydroxydopamine lesions. | the effects of the novel compound, (-)-osu6162 ((s)-(-)-3-methylsulfonylphenyl-1-propylpiperidine), on rotational behavior induced by dopamine receptor agonists was investigated in common marmosets (callithrix jacchus) with unilateral 6-hydroxydopamine lesions. (-)-osu6162 per se displayed no effect on the animals' behavior. on the other hand, pretreatment with (-)-osu6162 attenuated rotational behavior induced by apomorphine (apomorphini hydrochloridum), l-dopa (3,4-dihydroxyphenylalanine), and ... | 2000 | 10688984 |
| the effect of dopamine depletion from the caudate nucleus of the common marmoset (callithrix jacchus) on tests of prefrontal cognitive function. | this study examined the effects of depletion of dopamine from the caudate nucleus of the common marmoset (callithrix jacchus), on tasks sensitive to prefrontal damage (attentional set-shifting and spatial delayed response). there was a marked impairment in performance on the spatial delayed response task, but performance on the attentional set-shifting task was relatively preserved except for an impairment in re-engagement of a previously relevant perceptual dimension. this pattern of impairment ... | 2000 | 10718258 |
| the 5-ht1a antagonist, way 100 635, alleviates cognitive impairments induced by dizocilpine (mk-801) in monkeys. | central glutamate neurotransmission is modulated by an upregulatory cholinergic influence and an inhibitory serotonergic influence. in alzheimer's disease, cognitive decline is associated with loss of both glutamatergic and cholinergic neurones (francis et al., 1992, progress in neurobiology 39, 517-545). while therapeutic strategies for alleviating this cognitive decline have concentrated on restoring cholinergic tone, we suggest that 5-ht1a antagonists also have the potential to alleviate the ... | 2000 | 10728875 |
| leukaemia inhibitory factor in the endometrium of the common marmoset callithrix jacchus: localization, expression and hormonal regulation. | in the present study, changes in the immunohistochemical localization of leukaemia inhibitory factor (lif) in the endometrium during various phases of ovarian cyclicity of the common marmoset have been reported. lif was absent during the early and late follicular phases. lif was observed mainly in the cytoplasm of the endometrial glands during the early luteal phase, reached maximum intensity during the mid-luteal phase and declined again during late luteal phase. in-situ hybridization also show ... | 2000 | 10729316 |
| inhibitory control and affective processing in the prefrontal cortex: neuropsychological studies in the common marmoset. | the orbitofrontal cortex has been ascribed a role in the inhibitory control, as well as in the emotional control, of behaviour. while damage to the orbitofrontal cortex in humans and non-human primates can cause inflexibility, impulsiveness and emotional disturbance, the relationship between these effects are unclear. excitotoxic lesion studies in marmosets comparing the effects of cell loss within specific regions of the prefrontal cortex on performance of a range of behavioural tests reveal th ... | 2000 | 10731220 |
| combined use of the adenosine a(2a) antagonist kw-6002 with l-dopa or with selective d1 or d2 dopamine agonists increases antiparkinsonian activity but not dyskinesia in mptp-treated monkeys. | the novel selective adenosine a(2a) receptor antagonist kw-6002 improves motor disability in mptp-treated parkinsonian marmosets without provoking dyskinesia. in this study we have investigated whether kw-6002 in combination with l-dopa or selective d1 or d2 dopamine receptor agonists enhances antiparkinsonian activity in mptp-treated common marmosets. combination of kw-6002 with the selective dopamine d2 receptor agonist quinpirole or the d1 receptor agonist skf80723 produced an additive improv ... | 2000 | 10739638 |
| the effects of central aromatic amino acid dopa decarboxylase inhibition on the motor actions of l-dopa and dopamine agonists in mptp-treated primates. | 1. endogenous l-dopa may act as a neuromodulator contributing to the production of motor activity. we now investigate the effects of the centrally acting aromatic amino acid dopa decarboxylase (aadc) inhibitor nsd-1015 (3-hydroxybenzyl hydrazine) on the motor actions of l-dopa and dopamine agonist drugs in mptp treated common marmosets. 2. pretreatment with nsd-1015 (10 - 50 mg kg(-1); i.p.) worsened baseline motor deficits in mptp-treated common marmosets. similarly, it abolished l-dopa (5 - 18 ... | 2000 | 10742291 |
| effects of dietary oltipraz and ethoxyquin on aflatoxin b1 biotransformation in non-human primates. | following aflatoxin b1 (afb) exposure, rats readily develop liver tumors. however, treatment of rats with a variety of compounds, including the synthetic dithiolthione oltipraz and the antioxidant ethoxyquin, protects these rodents from afb-induced hepatocarcinogenesis. several epidemiological studies strongly suggest that afb is also a causative agent of liver cancer in humans. however, relatively little is known about the efficacy of cancer chemoprevention in human and non-human primates. to t ... | 2000 | 10746929 |
| motor neurons are rich in non-phosphorylated neurofilaments: cross-species comparison and alterations in als. | the localization and distribution of non-phosphorylated neurofilaments (np-nf) in the upper and lower motor neurons was investigated in the rat, the common marmoset, the rhesus monkey and man using the smi-32 antibody. within the spinal cord of all species studied, the most intense np-nf immunoreactivity was observed within the ventral horn alpha-motor neurons. concurrent staining for the cholinergic marker choline acetyltransferase (chat) demonstrated that virtually all of the chat-positive alp ... | 2000 | 10751564 |