Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin e levels in rats. | secoisolariciresinol diglucoside (sdg) is an important dietary lignan that is found at very high levels in flaxseed (1-4 %, w/w). flaxseed lignans have received much research interest in recent years because of reported phyto-oestrogenic, anticarcinogenic, and anti-atherogenic effects. previously, flaxseed feeding has been shown to decrease vitamin e concentrations in rats despite the antioxidant potential of sdg in vitro. sesamin, a sesame lignan, on the other hand has been shown to increase vi ... | 2004 | 15231000 |
| antidepressant effects of erbeta-selective estrogen receptor modulators in the forced swim test. | estradiol (e2) may influence depressive symptomology of women and decrease depressive behavior among rodents. the mechanism(s) for e2's antidepressant effects are not well understood. to determine whether antidepressant effects of e2 may involve actions at intracellular estrogen receptor (er) alpha or beta isoforms, selective er modulators (serms) were administered (10 microg sc) to ovariectomized rats 48 h before testing in the forced swim test, an animal model of depression, and the horizontal ... | 2004 | 15251261 |
| protective effects of sesamin and sesamolin on murine bv-2 microglia cell line under hypoxia. | sesamin and sesamolin were tested for their ability to protect bv-2 microglia from hypoxia-induced cell death. these antioxidants dose-dependently reduced hypoxia-induced lactate dehydrogenase (ldh) release and dichlorofluorescein (dcf)-sensitive reactive oxygen species (ros) production. their effects on signaling pathway mitogen-activated protein kinases (mapks) and caspase-3 in hypoxia-induced cell death were further examined. extracellular signal-regulated protein kinases (erk1/2), c-jun nh(2 ... | 2004 | 15308287 |
| high level estradiol impairs and low level estradiol facilitates non-spatial working memory. | the present study investigated the effect of different doses of estradiol treatment on performance in the non-spatial delayed alternation t-maze a task in which performance is mediated by the integrity of the prefrontal cortex (pfc). ovariectomized (ovx) female rats were injected with estradiol benzoate (0.3 microg/0.1 ml sesame oil (eb0.3), 5 microg/0.1 ml sesame oil (eb5) or 10 microg/0.1 ml sesame oil (eb 10)) or vehicle (sesame oil, 0.1 ml). approximately 2 h after each injection, animals we ... | 2004 | 15325778 |
| two distinct steroleosins are present in seed oil bodies. | in addition to oleosin isoforms, three minor proteins, sop1, 2 and 3 are present in sesame oil bodies. genes encoding sop1 and sop2, named caleosin and steroleosin for their calcium and sterol-binding capacity, respectively, have been cloned recently. blast sequence analysis of the first 32 n-terminal residues revealed that sop3 was presumably a steroleosin-like protein homologous to sop2. a putative cdna clone of sop3 was obtained by pcr, and subsequently confirmed by immunological recognition ... | 2004 | 15331088 |
| long-term effects of melatonin or 17 beta-estradiol on improving spatial memory performance in cognitively impaired, ovariectomized adult rats. | melatonin is an endogenously generated potent antioxidant. our previous studies indicate that melatonin improved learning and memory deficits in app695 transgenic mouse of alzheimer's disease. an ovariectomized (ovx) rat model which is characterized by progressive memory deficits, central cholinergic nerve system degeneration and differentiation/apoptosis imbalance is the ideal in vivo model in which to test the neuroprotective effects of melatonin. ovx sprague-dawley rats received daily injecti ... | 2004 | 15357665 |
| expression and characterization of extracellular fungal phytase in transformed sesame hairy root cultures. | a recombinant fungal phytase was produced by cultures of sesame hairy roots transformed with agrobacterium rhizogenes, purified and its molecular properties were characterized. its transcription level and the phytase production were rapidly increased after 4 weeks of the cultures, suggesting that its transcription and protein synthesis might concur. western blot analysis provided evidence that the recombinant fungal phytase was secreted into the liquid culture medium of the hairy roots. the phyt ... | 2004 | 15358375 |
| estrogen reduces serotonin-1a receptor-mediated oxytocin release and galpha(i/o/z) proteins in the hypothalamus of ovariectomized rats. | the present study examined the effect of estradiol on hypothalamic serotonin-1a (5-ht(1a)) receptor signaling in female rats. we first examined the time-course effects of a single injection of the 5-ht(1a) receptor agonist (+/-)8-oh-dpat (5, 15 or 30 min prior to decapitation), and dose response of (+)8-oh-dpat (50, 100, 200 or 500 microg/kg, s.c.) on plasma hormones in ovariectomized rats that received a daily injection of beta-estradiol 3-benzoate (10 microg/day, s.c.) or vehicle (sesame oil) ... | 2004 | 15385710 |
| activation of phenylpropanoid metabolism in sesame by over-expression of carrot calmodulin gene. | transgenic sesame (sesamum schinzianum asch.) was produced by agrobacterium-mediated transfection of a carrot calmodulin gene, cam-4, which was specifically expressed upon the contact of carrot cells with oligogalacturonide elicitor. coding region of cam-4 was ligated to the downstream of 35s promoter of cauliflower mosaic virus and subcloned into pmatgbo-db3.1. a. tumefaciens 4404 was transformed with the constructed vector, and the crown gall tissues formed in the sesame seedlings were transfe ... | 2004 | 15467207 |
| enhancing of erythromycin production by saccharopolyspora erythraea with common and uncommon oils. | the enhancing effect of various concentrations of 18 oils and a silicon antifoam agent on erythromycin production by saccharopolyspora erythraea was evaluated in a complex medium containing soybean flour and dextrin as the main substrates. the oils used consisted of sunflower, pistachio, cottonseed, melon seed, water melon seed, lard, corn, olive, soybean, hazelnut, rapeseed, sesame, shark, safflower, coconut, walnut, black cherry kernel and grape seed oils. the biomass, erythromycin, dextrin an ... | 2004 | 15480942 |
| dietary sesame oils inhibits iron-induced oxidative stress in rats [corrected]. | the high stability of sesame oil against oxidative deterioration is attributed to lignans in its non-glycerol fraction. the present study evaluates the effects of feeding sesame lignans (sesamin and sesamolin) on fe2+-induced oxidative stress in rats. three groups, each of sixteen male weanling wnin rats, were fed diets containing 200 g casein/kg and l00 g oil/kg (group 1, groundnut oil; group 2, sesame oil; group 3,sesame oil + sesamin (0.4 g/kg). after 45 d of feeding, eight rats from each gro ... | 2004 | 15526409 |
| sesame lignans enhance antioxidant activity of vitamin e in lipid peroxidation systems. | the antioxidant properties of sesame lignans (sesamol, sesamin and sesamolin) were evaluated in comparison to tocols (alpha- and gamma-tocopherols and alpha-tocotrienol) and butylated hydroxytoluene (bht) using the following in vitro lipid peroxidation systems: (i) rat liver microsomes and cumene hydroperoxide (cumooh)/fe2+-adp-nadph (enzymatic) or (ii) rat liver mitochondria and fe2+-ascorbate (nonenzymatic) systems. sesamol containing a free phenolic group inhibited lipid peroxidation in both ... | 2004 | 15532724 |
| effects of sesame oil on oxidative stress after the onset of sepsis in rats. | the aim of this study was to investigate effects of sesame oil on oxidative stress after the onset of sepsis in rats. effects of sesame oil on lipid peroxidation, superoxide anion, superoxide dismutase, catalase, glutathione, and nitrite after the onset of endotoxin intoxication were determined. to further examine the protective effect of sesame oil on sepsis, a mortality study was also conduced in cecal ligation and puncture-induced sepsis in rats. sesame oil was given orally 6 h after endotoxi ... | 2004 | 15545832 |
| chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent. | many popular dietary supplements are enriched in polyphenols such as the soy isoflavones, tea catechins, and resveratrol (from grape skins), each of which has been shown to have chemopreventive activity in cellular models of cancer. the proanthocyanidins, which are oligomers of the catechins, are enriched in grape seeds and form the basis of the dietary supplement grape seed extract (gse). evidence suggests that the proanthocyanidins may be metabolized to the monomeric catechins. this study was ... | 2004 | 15570052 |
| in vitro and in vivo evaluation of the metabolism and pharmacokinetics of sebacoyl dinalbuphine. | a diester prodrug of nalbuphine, sebacoyl dinalbuphine (sdn), and its long-acting formulation are currently being developed to prolong the duration of nalbuphine. a comparative in vitro hydrolysis study was conducted for sdn in rat, rabbit, dog, and human blood. both sdn and nalbuphine in blood or plasma were measured by high-performance liquid chromatography. the hydrolysis rates of sdn in blood were ranked as follows: rat > rabbit > human > dog. the rapid formation of nalbuphine in the blood a ... | 2004 | 15608131 |
| genotoxicity of vegetable cooking oils in the drosophila wing spot test. | seven vegetable oils consumed by humans were tested for genotoxic activity in the drosophila somatic mutation and recombination test. the oils included five seed oils (sesame, sunflower, wheat germ, flax, and soy oil) and both first-class extra-virgin and low-grade (refined) olive oil. larvae of the standard (std) and highly bioactive (norr) crosses of drosophila melanogaster were fed medium containing 6% and 12% of each of the oils. flax oil produced the strongest response, while sesame, wheat ... | 2005 | 15611939 |
| sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor-kappab. | sesame seed oil increases the survival after cecal ligation and puncture in mice and the increased il-10 levels with non-lethal lipopolysaccharides (lps) challenge. we showed that sesamin and sesamolin, major lignans of sesame oil, regulated lps-induced nitric oxide production in the murine microglia and bv-2 cell line. in this study, we studied the effect of sesamin on cytokine production by lps stimulation. the result showed that sesamin significantly inhibited lps-stimulated il-6 mrna and pro ... | 2005 | 15626481 |
| sesamol regulates plasminogen activator gene expression in cultured endothelial cells: a potential effect on the fibrinolytic system. | sesamol is a component in the nutritional makeup of sesame that was identified as an antioxidant. in recent years, the importance of the plasminogen activator (pa) and its adjustment factor, plasminogen activator inhibitor-1 (pai-1), in the prevention of atherosclerosis has gradually received recognition. the objective of this in vitro study was to demonstrate the effects of sesamol on pa and pai-1. we also compared the effects of sesamol with two well-known antioxidants, vitamins c and e, by us ... | 2005 | 15629242 |
| antioxidative roles of sesamin, a functional lignan in sesame seed, and it's effect on lipid- and alcohol-metabolism in the liver: a dna microarray study. | sesamin was orally administered to rats, and blood, bile and urine were collected periodically. over 40% of the dose of sesamin was detected in bile as glucuronides of 2-(3, 4-methylenedioxyphenyl)-6-(3, 4-dihydroxyphenyl)-cis-dioxabicyclo[3.3.0] octane and 2-(3, 4-dihydroxyphenyl)-6-(3, 4-dihydroxyphenyl)-cis-dioxabicyclo[3.3.0] octane by 24 hr after administration. antioxidant activities of these metabolites were compared and catechol metabolites showed strong radical scavenging activities aga ... | 2004 | 15630196 |
| antioxidative catechol lignans converted from sesamin and sesaminol triglucoside by culturing with aspergillus. | sesamin and sesaminol triglucoside in sesame seeds are major lignans that display an abundance of biological activities. although their antioxidative activity in vitro is weak, they have been reported to suppress oxidative stress in vivo. we investigated the production of new antioxidative lignans from sesame lignans by culturing with the genus aspergillus to enhance the function of food materials. media containing sesamin or sesaminol triglucoside increased antioxidative activity for dpph radic ... | 2005 | 15631503 |
| effects of vitamin e and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. | the preventive effects of sesamin, a lignan from sesame oil and vitamin e on hypertension and thrombosis were examined using stroke-prone spontaneously hypertensive rats (shrsp). animals at 5 weeks of age were separated into four groups: (i) control group; (ii) vitamin e group, which was given 1000 mg alpha-tocopherol/kg diet; (iii) sesamin group, given 1000 mg sesamin/kg diet; and (iv) vitamin e plus sesamin group, given 1000 mg alpha-tocopherol plus 1000 mg sesamin/kg diet for 5 weeks from 5 t ... | 2004 | 15649279 |
| modulating effect of sesamin, a functional lignan in sesame seeds, on the transcription levels of lipid- and alcohol-metabolizing enzymes in rat liver: a dna microarray study. | sesamin, a major lignan in sesame seeds, has multiple functions such as cholesterol-lowering and anti-hypertensive activities. to investigate the effect of sesamin on gene expression in the liver, a dna microarray analysis was carried out. the ingestion of sesamin dissolved in olive oil up-regulated the expression of 38 genes, 16 of which encode proteins possessing a lipid-metabolizing function, and 16 of which encode proteins possessing a xenobiotic/endogenous substance metabolizing function. i ... | 2005 | 15665483 |
| mechanisms of increased survival after lipopolysaccharide-induced endotoxic shock in mice consuming olive oil-enriched diet. | we examined the impact of dietary fatty acid intake on lipopolysaccharide (lps)-induced endotoxic shock. c57bl/6j mice were fed for 6 weeks with a commercial laboratory chow (cc) or with test chows containing 7% (w/w) canola oil (co), sesame oil (seo), soybean oil (so), or virgin olive oil (oo). the increase in body weight and energy consumption were similar for all diets tested. in the sixth week, mice were injected intraperitoneally with 400 microg of bacterial lps to induce endotoxic shock. l ... | 2005 | 15665734 |
| traditional massage of newborns in nepal: implications for trials of improved practice. | mustard oil massage of newborns is an integral component of traditional care practices in many communities. recent evidence suggests that this practice may have detrimental effects, particularly for preterm infants or for those whose skin barrier function is otherwise sub-optimal. other natural oils such as sunflower, sesame or safflower seed oil may have a beneficial impact on newborn health and survival. little is known, however, about cultural and other factors related to the acceptance and u ... | 2005 | 15677372 |
| beneficial effects of a polar fraction of garlic (allium sativum linn) oil in rats fed with two different high fat diets. | feeding a diet containing 20% of sesame oil (so) or coconut oil (cno) along with 2% cholesterol to rats for two months showed differences in their serum and tissue lipid profile and certain enzyme activities. hyperlipidemia and related oxidative effects were more pronounced in coconut oil fed rats than those fed sesame oil. feeding a combination of the oils (10% cno +10% so) lowered significantly the hyperlipidemia and certain other deleterious effects of cno. feeding a polar fraction of garlic ... | 2005 | 15691069 |
| fenvalerate-induced oxidative damage in rat tissues and its attenuation by dietary sesame oil. | the primary objective of this study was to investigate the propensity of fenvalerate (fen), a synthetic pyrethroid to induce oxidative stress (os) in various tissues of growing male rats following a short-term (28 days) dietary regimen and its possible attenuation by dietary (10%) sesame oil (so). fen incorporated diet was fed to weanling male rats at the dosages of 0, 250, 500 and 1000 ppm. terminally, significant induction of os in liver, thymus, spleen and erythrocytes was noticed at higher d ... | 2005 | 15696646 |
| effects of estrogens on cardiovascular structure in uninephrectomized shrsp rats. | the risk of cardiovascular disease in uremic patients is greater in male than in female patients. estrogens seem to play a cardioprotective role until menopause. experimental data on the effect of estrogens on cardiovascular damage are controversial and potential underlying mechanisms especially in renal failure have not been fully clarified. | 2005 | 15698424 |
| attenuating 5alpha-pregnane-3alpha-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures. | progesterone has antiseizure effects, which may be due to the actions of its 5alpha-reduced metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-thp). whether metabolism of progesterone to 3alpha,5alpha-thp in the hippocampus is essential for its antiseizure effects was investigated. in experiment 1, ovariectomized rats were administered subcutaneous progesterone (500 microg) or vehicle (sesame oil), followed 1 hour later by subcutaneous administration of an inhibitor of the 5alpha-reducta ... | 2005 | 15710296 |
| immunolocalization of retinoic acid receptors in the mammalian olfactory system and the effects of olfactory denervation on receptor distribution. | all-trans retinoic acid (atra), a metabolite of vitamin a, binds to retinoic acid receptors (rars) to mediate gene transcription in target cells. we previously found that an atra supplement enhanced olfactory recovery rate in adult mice after olfactory bulb deafferentation. in this study, we examined the cellular localization of raralpha, rarbeta, and rargamma and the effects of surgery and atra treatment using immunocytochemistry. mice received a left olfactory nerve transection with the right ... | 2005 | 15730877 |
| supplementation of l-arginine prevents glucocorticoid-induced reduction of bone growth and bone turnover abnormalities in a growing rat model. | the present study was designed to evaluate the effects of glucocorticoid (gc) treatment on bone turnover and bone mineral density in the growing rat. because of the recent evidence that nitric oxide (no) can counteract prednisolone-induced bone loss in mature rats, we examined the effect on bone of the no donor l: -arginine in young male rats, in which bone mass is increased by the same biological mechanism as in children and adolescents. thirty-six 10-week-old sprague-dawley male rats were assi ... | 2005 | 15750691 |
| consumption of sesame oil muffins decreases the urinary excretion of gamma-tocopherol metabolites in humans. | sesame seed and oil consumption previously increased human plasma gamma-tocopherol (gamma-t) concentrations. this was attributed to the sesame lignans sesamin and sesamolin. here, we studied the inhibition of vitamin e metabolism by a single dose of sesame oil lignans coingested with deuterated alpha- and gamma-tocopherols in human volunteers. the urinary excretion of gamma-t metabolites was significantly lower in sesame oil treated than in control subjects. concentrations of tocopherols in bloo ... | 2004 | 15753171 |
| dietary modulation of 7,12-dimethylbenz[a]anthracene (dmba)-induced adrenal toxicity in female sprague-dawley rats. | in this study, dietary modulation of 7,12-dimethylbenz[a]anthracene (dmba)-induced adrenal toxicity in rats was investigated. beginning at postnatal day (pnd) 21, female sprague-dawley rats were fed either soy-containing nih-31 diet or soy- and alfalfa-free 5k96 diet. on the first day of diestrus when the animals were pnd 50 +/- 5, rats received either an oral dose of 80 mg/kg dmba or sesame oil, the vehicle, and were sacrificed at 24, 36, or 48 h after treatment. apoptosis was manifested at 24 ... | 2005 | 15778017 |
| alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor autoradiography in mouse brain after single and repeated withdrawal from diazepam. | withdrawal from chronic treatment with benzodiazepines is associated with increased neuronal excitability leading to anxiety, aversive effects and increased seizure sensitivity. after repeated withdrawal experiences, seizure sensitivity increases while withdrawal-induced anxiety and aversion decrease. we used autoradiographical methods employing [(3)h]ro48 8587, a selective ligand for glutamatergic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (ampa) receptors, to study withdrawal-induced ... | 2005 | 15787709 |
| erbeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats. | 17beta-estradiol (e2) may influence anxiety behavior; however, its effects and mechanisms are not well understood. to determine whether e2's effects on anxiety behavior may involve actions at intracellular estrogen receptor (er) alpha or beta isoforms, selective er modulators (serms) were administered (10 microg; s.c.) to ovariectomized rats 48 h before testing for anxiety behavior. rats received sesame oil vehicle, 17beta-e2, which has a high affinity for eralpha and erbeta, or serms that vary ... | 2005 | 15798780 |
| estrogen modifies stress response of catecholamine biosynthetic enzyme genes and cardiovascular system in ovariectomized female rats. | estrogen is likely involved in the gender specific differences in coping with stress. activation of catecholamine (ca) biosynthetic enzyme gene expression in central and peripheral ca systems plays a key role in response to stress and in regulation of the cardiovascular system. here we examined whether estradiol can modulate response of hypothalamic-pituitary-adrenal axis (hpa), gene expression of enzymes related to ca biosynthesis in several noradrenergic locations, tetrahydrobiopterin (bh4) co ... | 2005 | 15802180 |
| antidepressant and memory affecting influence of estrogen and venlafaxine in ovariectomized rats. | the experiments presented in this paper aimed to investigate whether estrogen level changes in oviariectomized rats (ovx) may lead to depression and memory disorders, and whether the effects of such changes may be reversible following administration of a new antidepressant, venlafaxine (cas 9930-78-4, ven, efectin). the porsolt forced swimming test and morris water maze test were carried out on female wistar rats after ovariectomy and in sham-ovariectomized rats. ven 20 mg/kg was administered or ... | 2005 | 15819387 |
| actions at gaba(a) receptors in the hippocampus may mediate some antiseizure effects of progestins. | progestins can have antiseizure effects; however, the mechanisms and sites of action of these effects are not well-understood. whether progesterone's actions at gaba(a) receptors in the hippocampus are important for its antiseizure effects was investigated. in experiment 1, ovariectomized rats were administered sesame oil vehicle or a regimen of progesterone (500 microg sc, which produces physiological concentrations in plasma and the hippocampus), followed 2.5 hours later by administration of s ... | 2005 | 15820338 |
| modulation of blood pressure, lipid profiles and redox status in hypertensive patients taking different edible oils. | free oxygen radicals and insufficiency of antioxidants have been implicated in the pathogenesis of hypertension. we determined the effect of edible oils on blood pressure, lipid profiles and redox status in hypertensive patients given antihypertensive therapy (nifedipine-calcium channel blocker). | 2005 | 15820483 |
| systemic treatment with n-6 polyunsaturated fatty acids attenuates el4 thymoma growth and metastasis through enhancing specific and non-specific anti-tumor cytolytic activities and production of th1 cytokines. | recently, there has been a great interest in the effects of different types of n-6 polyunsaturated acids (n-6 pufas) upon the immune system and cancer development. however, the effects of n-6 pufas are still controversial and as yet undefined. the present study aimed to investigate the anti-tumor effects of n-6 pufas against el4 thymoma and the associated immune mechanisms. to this, sesame oil, a vegetable oil enriched with n-6 pufas, or free linoleic acid (la) were administered intraperitoneall ... | 2005 | 15829411 |
| isolation, molecular characterization and antimicrobial resistance patterns of salmonella and escherichia coli isolates from meat-based fast food in lebanon. | the aim of this study was to characterize at the molecular level the different stains of salmonella spp. and escherichia coli that were isolated from meat-based fast food in lebanon. in addition, this study evaluated the resistance of those strains to different antimicrobials that are commonly used. the foods included were lahm-bi-ajeen (lba, meat pies) and shawarma (lebanese meat sandwiches similar to gyros and donairs, containing meat, vegetables, and sesame seeds-oil-based sauce). polymerase ... | 2005 | 15833239 |
| dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-alpha expression in the rat uterus. | tamoxifen, a selective estrogen receptor modulator, has agonist or antagonist activity, depending on the target tissue. the estrogen-like agonist effects of tamoxifen in the uterus are mediated primarily by 4-hydroxytamoxifen (4oh), the major active metabolite. tamoxifen, 4oh and estradiol-17beta (e2) all bind to estrogen receptors (eralpha and erbeta), but with different affinities, suggesting that these ligands are capable of producing differential in vivo effects on the uterus. however, diffe ... | 2005 | 15846122 |
| genetic and environmental risk factors for the development of food allergy. | to review recent clinical and experimental studies of genetic and environmental risk factors for the development of food allergy. | 2005 | 15864084 |
| dietary sesamin is converted to enterolactone in humans. | sesamin, a major sesame seed lignan, has many biological actions. the specific mechanisms for most of these actions as well as the full metabolic pathway of sesamin in humans are unclear. two experiments were carried out to determine whether postprandial plasma enterolactone is related to sesamin concentration in sesame seeds and whether enterolactone is the major product of the in vitro fermentation of sesamin. four subjects (3 women, 1 man) were given a single dose of sesame seeds after they c ... | 2005 | 15867281 |
| the antinociceptive and anti-inflammatory effects of a long-acting depot formulated ketorolac in rats. | currently, no long-acting nonsteroidal anti-inflammatory drug is available clinically for the treatment of long-lasting pain. the aim of the study was to evaluate the antinociceptive and anti-inflammatory effects and duration of action of a novel depot formulation of ketorolac benzyl ester in sesame oil. | 2005 | 15869000 |
| isolation and characterization of diazotrophic growth promoting bacteria from rhizosphere of agricultural crops of korea. | free-living nitrogen fixing bacteria were isolated from rhizosphere of seven different plant namely sesame, maize, wheat, soybean, lettuce, pepper and rice grown in chungbuk province, korea. five isolates with nitrogenase activity above 150nmol(-1) mg(-1) protein were identified based on, phenotypic and 16s rdna sequences analysis. the strains were identified as stenotrophomonas maltophilia (pm-1, pm-26), bacillus fusiformis (pm-5, pm-24) and pseudomonas fluorescens (pm-13), respectively. all th ... | 2005 | 15881829 |
| gas chromatographic, mass spectrometric and stable carbon isotopic investigations of organic residues of plant oils and animal fats employed as illuminants in archaeological lamps from egypt. | man's use of illuminants in lamps or as torches to extend the working day and range of environments accessible to him would have been a major technological advance in human civilisation. the most obvious evidence for this in the archaeological record comes from pottery and stone vessels showing sooting due to the use of a wick in conjunction with a lipid-based fuel or illuminant. a wide range of potential fuels would have been exploited depending upon availability and burning requirements. repor ... | 2005 | 15912234 |
| yeasthub: a semantic web use case for integrating data in the life sciences domain. | as the semantic web technology is maturing and the need for life sciences data integration over the web is growing, it is important to explore how data integration needs can be addressed by the semantic web. the main problem that we face in data integration is a lack of widely-accepted standards for expressing the syntax and semantics of the data. we address this problem by exploring the use of semantic web technologies-including resource description framework (rdf), rdf site summary (rss), rela ... | 2005 | 15961502 |
| long-term melatonin or 17beta-estradiol supplementation alleviates oxidative stress in ovariectomized adult rats. | melatonin is an endogenously generated potent antioxidant. our previous results indicated that melatonin improved learning and memory deficits in the transgenic mouse model of alzheimer's disease (ad) and ovariectomized (ovx) rats by improving cholinergic nerve system dysfunction, preventing apoptosis. in this study we aim to investigate the antioxidative effects of melatonin or estradiol in the brains of ovariectomized rats. ovx sprague-dawley rats received daily injections of melatonin (5, 10, ... | 2005 | 15964511 |
| oxidative toxicity in bv-2 microglia cells: sesamolin neuroprotection of h2o2 injury involving activation of p38 mitogen-activated protein kinase. | reactive oxygen species (ros) has been proposed to play a pathogenic role in neuronal injury. sesame antioxidants that inhibit lipid peroxidation and regulate cytokine production may suppress ros generation. in this study, we focused on the effect of sesamolin on h2o2-induced neurotoxicity and ros production in the murine microglial cell line bv-2. results indicate that the h2o2 elicited bv-2 cell death in a concentration- and time-dependent manner. ros generation in bv-2 cells was time-dependen ... | 2005 | 15965073 |
| comparison of phytase production on wheat bran and oilcakes in solid-state fermentation by mucor racemosus. | comparisons were made for phytase production using wheat bran (wb) and oilcakes as substrates in solid-state fermentation (ssf) by mucor racemosus nrrl 1994. wb was also used as mixed substrate with oil cakes. sesame oil cake (soc) served as the best carbon source for phytase synthesis by the fungal strain as it gave the highest enzyme titres (30.6 u/gds). groundnut oil cake (goc) also produced a reasonably good quantity of enzyme (24.3 u/gds). enzyme production on wb was surprisingly much less ... | 2006 | 15979307 |
| replacement by drosophila melanogaster protamines and mst77f of histones during chromatin condensation in late spermatids and role of sesame in the removal of these proteins from the male pronucleus. | chromatin condensation is a typical feature of sperm cells. during mammalian spermiogenesis, histones are first replaced by transition proteins and then by protamines, while little is known for drosophila melanogaster. here we characterize three genes in the fly genome, mst35ba, mst35bb, and mst77f. the results indicate that mst35ba and mst35bb encode dprota and dprotb, respectively. these are considerably larger than mammalian protamines, but, as in mammals, both protamines contain typical cyst ... | 2005 | 15988027 |
| beyond vitamin e supplementation: an alternative strategy to improve vitamin e status. | vitamin e has many reported health effects and is recognized as the most important lipid-soluble, chain-breaking antioxidant in the body. vitamin e has also been reported to play a regulatory role in cell signalling and gene expression. epidemiological studies show that high blood concentrations of vitamin e are associated with a decreased risk of cardiovascular diseases and certain cancers. yet, high doses of supplemental vitamin e have been associated with an elevated risk of heart failure and ... | 2005 | 16008112 |
| the antinociceptive and anti-inflammatory effects of five depot formulations of ketorolac propyl ester in rats. | ketorolac is a potent nonsteroidal anti-inflammatory drug. recently, a ketorolac prodrug, ketorolac propyl ester, was synthesized in our laboratory. the aim of the study was to evaluate the antinociceptive and anti-inflammatory effects of ketorolac propyl ester in five depot formulations. the vehicles used in these formulations were injectable vegetable oils, i.e., sesame oil, peanut oil, soybean oil, castor oil, and cottonseed oil. the traditional therapentic form of ketorolac tromethamine in s ... | 2005 | 16060403 |
| biosynthesis of medium chain length poly(3-hydroxyalkanoates) (mcl-phas) by comamonas testosteroni during cultivation on vegetable oils. | comamonas testosteroni has been studied for its ability to synthesize and accumulate medium chain length poly(3-hydroxyalkanoates) (mcl-phas) during cultivation on vegetable oils available in the local market. castor seed oil, coconut oil, mustard oil, cotton seed oil, groundnut oil, olive oil and sesame oil were supplemented in the mineral medium as a sole source of carbon for growth and phas accumulation. the composition of phas was analysed by a coupled gas chromatography/mass spectroscopy (g ... | 2005 | 16084364 |
| anti-apoptotic role of retinoic acid in the inner ear of noise-exposed mice. | exposure to loud noise can induce temporary or permanent hearing loss, and acoustic trauma is the major cause of hearing impairment in industrial nations. however, the mechanisms underlying the death of hair cells after acoustic trauma remain unclear. in addition to its involvement in cellular stress and apoptosis, the c-jun n-terminal kinase (jnk), a member of the mitogen-activated protein kinase family, is involved in cell survival, transformation, embryonic morphogenesis, and differentiation. ... | 2005 | 16084493 |
| estrogen-priming can enhance progesterone's anti-seizure effects in part by increasing hippocampal levels of allopregnanolone. | estrogen can be proconvulsant, while progesterone and its metabolite allopregnanolone typically have anti-seizure effects. we investigated whether estrogen-priming also has anti-seizure effects by altering progesterone's metabolism to allopregnanolone, or levels of brain-derived neurotrophic factor (bdnf), in the hippocampus. two experiments investigated effects of different estrogen-priming regimen (experiment 1--10 microg; experiment 2--2 microg) on pentylenetetrazole (ptz)-induced seizures an ... | 2005 | 16085296 |
| effect of sesame oil on oxidative-stress-associated renal injury in endotoxemic rats: involvement of nitric oxide and proinflammatory cytokines. | this study aimed to investigate the effect of sesame oil on oxidative stress-associated renal injury induced by lipopolysaccharide in rats. the effects of sesame oil on renal injury, oxidative stress, hydroxyl radical, superoxide anion, nitric oxide, and proinflammatory cytokines were assessed after a lipopolysaccharide challenge. sesame oil attenuated lipopolysaccharide-induced renal injury, decreased lipid peroxidation, increased the activities of superoxide dismutase, catalase, and glutathion ... | 2005 | 16135968 |
| histological evaluation of brain damage caused by crude quinolizidine alkaloid extracts from lupines. | the effects of the intracerebroventricular (icv) administration of crude extracts of lupin quinolizidine alkaloids (lqas) were studied in adult rat brain tissue. mature l. exaltatus and l. montanus seeds were collected in western mexico, and the lqas from these seeds were extracted and analyzed by capillary gas chromatography. this lqa extract was administered to the right lateral ventricle of adult rats through a stainless steel cannula on five consecutive days. while control animals received 1 ... | 2005 | 16136497 |
| potential of oil-based formulations of beauveria bassiana to control triatoma infestans. | the in vitro development of beauveria bassiana conidia was monitored when immersed in six concentrations of seven non-ionic (mp 6400, mp 600, renex 60, renex 95, span 80, tween 20 and tween 80) and three anionic (dos 75, hostapaval bvq 9 and surfax 220) surfactants and 11 vegetable oils (linseed, soybean, groundnut, rapeseed, thistle, sunflower, olive, sesame, corn, castor, and babassu). the influence of the oils on the settling behavior of triatoma infestans nymphs and the activity of an oil-wa ... | 2005 | 16160769 |
| reproductive abnormalities in adult male mice following preimplantation exposures to estradiol or pesticide methoxychlor. | adult females of icr strain of mice were bred, separated into different experimental groups, and treated as follows. on days 2-4 of pregnancy, the mice received daily subcutaneous injections of either 0.05 ml sesame oil (vehicle) or same volume of 5.0mg of purified methoxychlor (mxc) suspended in the vehicle. another group received a single subcutaneous injection of 1.0 microg of estradiol-17beta (e) on day 2 of pregnancy only. male offspring were tested at 3 and 6 months of age. at 3 months, e ... | 2006 | 16162399 |
| influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. | the present study was carried out to assess the influence of sesame oil on blood glucose, lipid peroxidation, and status of antioxidants in normal and streptozotocin (stz) diabetic rats. diabetes was induced in adult female albino wistar rats weighing 180-200 g by administration of stz (40 mg/kg of body weight) intraperitonially. both normal and diabetic rats were fed with a commercial diet containing 2% oil supplemented with 6% sesame oil for 42 days. diabetic rats had elevated levels of blood ... | 2005 | 16176150 |
| antibacterial activity of ocimum sanctum l. fixed oil. | ocimum sanctum fixed oil showed good antibacterial activity against staphylococcus aureus, bacillus pumilus and pseudomonas aeruginosa, where s. aureus was the most sensitive organism. sesame and soyabean oils also showed moderate activity against s. aureus. higher content of linolenic acid in o. sanctum fixed oil could contribute towards its antibacterial activity. the antibacterial activity combined with anti-inflammatory and analgesic activities of the oil, could make it useful in inflammator ... | 2005 | 16187537 |
| prenatal androgen exposure modulates cellular and humoral immune function of black-headed gull chicks. | avian eggs contain considerable amounts of maternal yolk androgens, which have been shown to beneficially influence the physiology and behaviour of the chick. as androgens may suppress immune functions, they may also entail costs for the chick. this is particularly relevant for colonial species, such as the black-headed gull (larus ridibundus), in which the aggregation of large numbers of birds during the breeding season enhances the risk of infectious diseases for the hatching chick. to test th ... | 2005 | 16191605 |
| [determination of fumonisin biosynthesis gene and toxicity of fusarium moniliforme strains isolated in china]. | to study the relationship between fumonisin biosynthesis gene and toxicity of fusarium moniliforme isolated in china. | 2005 | 16194380 |
| spectroscopic analysis of highly concentrated suspensions of bovine somatotropin in sesame oil. | spectroscopy was employed to analyze the structural and thermal stability of highly concentrated oil suspensions of bovine somatotropin (bst). these methods were then compared with more dilute aqueous solutions (1 and 10 mg/ml). all oil suspensions were opaque, viscous, and highly concentrated in bst (>300 mg/ml) and thus provided unique analytical challenges. using front surface fluorescence and atr-ftir spectroscopy, protein structure and stability could be directly monitored in this environme ... | 2005 | 16200543 |
| dietary sesame seeds elevate alpha-tocopherol concentration in rat brain. | we have previously reported that dietary sesame lignan elevates alpha-tocopherol concentration and decreases lipid peroxidation in tissues and serum of rats fed alpha-tocopherol. in this study, the effect of dietary sesame seeds on alpha-tocopherol concentration and lipid peroxidation in rat brain was examined. in experiment 1, male wistar rats (4 wk old) were fed a vitamin e-free diet, or a diet containing alpha-tocopherol with or without sesame seeds for 1, 4 and 8 wk. the dietary sesame seeds ... | 2005 | 16261993 |
| sesame seed products contaminated with salmonella: three outbreaks associated with tahini. | in november 2002, the first of three outbreaks of salmonella montevideo infection in australia and new zealand was identified in new south wales, australia. affected persons were interviewed, and epidemiologically linked retail outlets inspected. imported tahini was rapidly identified as the source of infection. the contaminated tahini was recalled and international alerts posted. a second outbreak was identified in australia in june-july 2003 and another in new zealand in august 2003. in a tota ... | 2005 | 16274503 |
| [food allergy--effect of physician attitude on the diagnosis and reported prevalence]. | there is great variation in the reported incidence of food allergies, especially the estimated cross allergy to cow's milk and soy. | 2005 | 16281757 |
| cloning of oleosin, a putative new hazelnut allergen, using a hazelnut cdna library. | the clinical presentation of non-pollen related allergy to hazelnut can be severe and systemic. so far, only a limited number of non-pollen related hazelnut allergens have been identified and characterized. the aim of this study was to identify and clone new hazelnut allergens. a lambda zap cdna library of hazelnut was constructed. the library was screened with serum of six hazelnut allergic patients displaying different ige-binding patterns on hazelnut immunoblot. rapid amplification of cdna en ... | 2006 | 16288502 |
| effects of experimental hyperandrogenemia on the female rat reproductive axis: suppression of progesterone-receptor messenger rna expression in the brain and blockade of luteinizing hormone surges. | preovulatory gonadotropin-releasing hormone and luteinizing hormone (lh) surges depend on activation of estrogen-inducible progesterone receptors (prs) in the hypothalamus. although testosterone treatment can suppress lh secretion under some circumstances, how androgens affect the release of preovulatory hormone surges, and the cellular mechanisms by which androgens exert any such effects, remains unknown. | 2005 | 16290888 |
| protective effect of 1,2,4-benzenetriol on lps-induced no production by bv2 microglial cells. | hydroxyhydroquinone or 1,2,4-benzenetriol (bt) detected in the beverages has a structure that coincides with the water-soluble form of a sesame lignan, sesamol. we previously showed that sesame antioxidants had neuroprotective abilities due to their antioxidant properties and/or inducible nitric oxide synthase (inos) inhibition. however, studies show that bt can induce dna damage through the generation of reactive oxygen species (ros). therefore, we were interested to investigate the neuroprotec ... | 2006 | 16308662 |
| review of statutory and voluntary labelling of food allergens. | food allergy represents an increasingly important health problem, with prevalence in western europe continuing to rise. while some reactions are mild, others can include life-threatening anaphylactic shock. it is estimated that food allergies affect 1-2% of the adult population and < or =8% of children. relatively few foods are to blame for a large majority of allergic reactions to food in the uk, with most reactions being to milk, eggs, peanuts (arachis hypogea), nuts, fish, shellfish, soyabean ... | 2005 | 16313690 |
| serum concentrations of 17beta-estradiol in ovariectomized rats during two times six weeks crossover treatment by daily injections in comparison with slow-release pellets. | estrogens exert widespread biological functions that reach far beyond their well-known role in reproduction. exogenous administration of 17beta-estradiol to ovariectomized experimental animals is of the utmost importance in elucidating its mechanisms of action. in the present study, we compared two different modes of exogenous administration of 17beta-estradiol to ovariectomized rats in relation to the serum 17beta-estradiol concentrations over prolonged periods of time. 17beta-estradiol was adm ... | 2005 | 16319044 |
| effects of topical sesame oil on oxidative stress in rats. | to assess the effects of topical sesame oil on systemic oxidative stress in rats. | 2005 | 16320859 |
| [effects of bisphenol a on the placental function and reproduction in rats]. | the aim of this study was to investigate the effects of bisphenol a (bpa), an estrogen-like environmental endocrine disrupter, on the placental function and reproduction in rats. the mrna levels of the placental prolactin-growth hormone(prl-gh) gene family, placental trophoblast cell frequency and reproductive data were analyzed. | 2005 | 16323634 |
| sesamol induces nitric oxide release from human umbilical vein endothelial cells. | sesamol, which is derived from sesame seed lignans, is reportedly an antioxidant. nitric oxide (no), the most important vascular relaxing factor, is regulated in the endothelium. in addition, no is involved in protecting endothelium and has antiatherosclerotic and antithrombotic activities. the endothelium produces no through the regulation of both endothelial no synthase (enos) expression and activity in endothelial cells. this study sought to investigate the effect of sesamol on no released fr ... | 2005 | 16329468 |
| [study on gene polymorphism of fumonisin-producing fusarium verticillioides strains]. | to study the gene polymorphism and genetic variation of fumonisin-producing or non-producing fusarium verticillioides strains isolated from different geographical areas and different samples. | 2005 | 16329605 |
| estrogen regulation of the rat anterior pituitary gland proteome. | estrogen is known to affect the regulation of all six of the established anterior pituitary gland (ap) hormones, but little is known of the specifics of its regulation of the ap hormones, their isoforms, and nonhormonal ap proteins. we used difference gel electrophoresis in conjunction with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and peptide mass fingerprinting to quantify the effects of estrogen on the ap-soluble protein fraction in rats. two-month-old rats ... | 2005 | 16339744 |
| sesamin ingestion regulates the transcription levels of hepatic metabolizing enzymes for alcohol and lipids in rats. | sesamin, a major lignan in sesame seeds, has multiple functions such as stimulation effect of ethanol metabolism in mice and human, and prevention of ethanol-induced fatty liver in rats. however, the mechanism has not been clarified yet. | 2005 | 16344595 |
| isolation, growth characteristics, and long-term storage of fungi cultivated by attine ants. | seven pure-culture strains of fungi cultivated by attine ants (ant-garden fungi) were isolated from locally maintained leaf-cutting ant colonies. an ant-garden fungus strain obtained from an atta cephalotes colony, when offered to ants of the colony from which the fungus was isolated, was accepted as their own. young fungus cultures were harvested and incorporated into the fungus garden, and cultures of intermediate age were used to begin a new fungus garden; old cultures were simply harvested. ... | 1989 | 16347927 |
| metabolism of different adipose tissues in vivo in the rat. | to explore regional differences in triglyceride retention in white adipose tissues of growing male rats, the mass of adipocytes from epididymal, retroperitoneal, inguinal, and mesenteric tissues were followed with time. in order to attempt to explain regional differences, adipose tissue metabolism was studied in vivo and in vitro. (u-14c) oleic acid in sesame oil was given by gastric gavage to conscious male and female rats, and accumulation and half-life of radioactivity measured. lipoprotein l ... | 1993 | 16350320 |
| microarray profiling of gene expression patterns in adult male rat brain following acute progesterone treatment. | progesterone can influence various behaviors in adult male rats, however, little is known about which particular genes are regulated by progesterone in the male rat brain. using focused microarray technology, we where able to define a subset of genes that are responsive to progesterone. nylon membrane-based cdna microarrays were used to profile gene expression patterns in the preoptic area/mediobasal hypothalamus (poa/mbh) of male rat brain 7 h following a single injection of progesterone. rna w ... | 2006 | 16376865 |
| estrogen and progesterone affect cocaine pharmacokinetics in female rats. | several studies have reported sex differences in behavioral responses to cocaine whereby females display a greater degree of locomotor activity. fluctuations in estrogen and progesterone during the estrous cycle have been postulated to underlie these behavioral differences. in this study, we tested the hypothesis that hormonal replacement (estrogen or progesterone) in ovariectomized rats affects cocaine pharmacokinetics. we found that estrogen replacement did not affect cocaine-induced locomotor ... | 2006 | 16377436 |
| cloning and expression of a seed-specific metallothionein-like protein from sesame. | a cdna clone, simt encoding an ec type of metallothionein (mt)-like protein, was isolated from maturing seeds of sesame (sesamum indicum l.), and its deduced protein sequence shared 47-65% similarity to other known ec type of mt-like proteins with three highly conserved cysteine-rich segments. the transcript of simt was exclusively accumulated in maturing seeds from two weeks after flowering to the end of seed maturation. the results of a southern blot analysis suggested that one simt and one si ... | 2005 | 16377889 |
| administration of estrogen to ovariectomized rats promotes conditioned place preference and produces moderate levels of estrogen in the nucleus accumbens. | estrogen (e2) can modulate a variety of functional processes, including conditioning. however, the precise relationship between e2 and these processes is not entirely understood. indeed, the nature of e2's effects on conditioning may depend upon several factors, including, but not limited to, the task examined, route of e2 administration, bioavailability of e2 administered, and/or duration of e2 exposure. the present studies examined the effects of e2 on conditioned place preference (cpp), and e ... | 2006 | 16388786 |
| the progesterone derivative dydrogesterone down-regulates neurokinin 1 receptor expression on lymphocytes, induces a th2 skew and exerts hypoalgesic effects in mice. | accumulating evidence indicates that the neuropeptide substance p (sp) is predominantly involved in neurogenic inflammation and pain perception via its high-affinity neurokinin 1 receptor (nk-1r). intriguingly, decreased pain sensitivity is found to be associated with high plasma progesterone levels. we hypothesize that progesterone may attenuate nociception and associated inflammatory response via nk-1r-dependent pathways. to address our hypothesis, we incubated splenic lymphocytes from cba/j f ... | 2006 | 16389545 |
| peroxisome proliferator-activated receptor alpha plays a vital role in inducing a detoxification system against plant compounds with crosstalk with other xenobiotic nuclear receptors. | peroxisome proliferator-activated receptor alpha (pparalpha) is thought to play an important role in lipid metabolism in the liver. to clarify the extra-hepatic and/or unknown function of pparalpha, we previously performed a proteome analysis of the intestinal proteins and identified 17beta-hydroxysteroid dehydrogenase type 11 as a mostly induced protein by a pparalpha ligand [motojima, k. (2004) eur. j. biochem. 271, 4141-4146]. because of its supposed wide substrate specificity, we examined th ... | 2006 | 16403017 |
| induction of renal cytochrome p450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid. | dietary gamma-linolenic acid (gla), a omega-6 polyunsaturated fatty acid found in borage oil (bor), lowers systolic blood pressure in spontaneously hypertensive rats (shrs). gla is converted into arachidonic acid (aa) by elongation and desaturation steps. epoxyeicosatrienoic acids (eets) and 20-hydroxyeicosatetraenoic acid (20-hete) are cytochrome p450 (p450)-derived aa eicosanoids with important roles in regulating blood pressure. this study tested the hypothesis that the blood pressure-lowerin ... | 2006 | 16421287 |
| neonatal genistein or bisphenol-a exposure alters sexual differentiation of the avpv. | there is growing concern that naturally occurring and chemically manufactured endocrine-active compounds (eacs) may disrupt hormone-dependent events during central nervous system development. we examined whether postnatal exposure to the phytoestrogen genistein (gen) or the plastics component bisphenol-a (bis) affected sexual differentiation of the anteroventral periventricular nucleus of the hypothalamus (avpv) in rats. the avpv is sexually differentiated in rodents. the female avpv is larger t ... | 2006 | 16427766 |
| identification of oleosins as major allergens in sesame seed allergic patients. | the prevalence of sesame allergy is increasing in european countries. cases of severe allergy lack any evidence of specific immunoglobulin (ig)es by prick tests and capsystem-feia. the reasons for this negativity are unknown. | 2006 | 16436145 |
| androgen effects on hippocampal ca1 spine synapse numbers are retained in tfm male rats with defective androgen receptors. | the effects of estradiol benzoate (eb), dihydrotestosterone (dht), or the antiandrogen hydroxyflutamide on ca1 pyramidal cell dendritic spine synapses were investigated in adult male rats. to elucidate the contribution of the androgen receptor to the hormone-induced increase in hippocampal ca1 synapses, wild-type males were compared with males expressing the tfm mutation, which results in synthesis of defective androgen receptors. orchidectomized rats were treated with eb (10 microg/rat.d), dht ... | 2006 | 16439462 |
| open sesame! coxsackieviruses conspire to trespass the tight junctional gate. | in the january 13 issue of cell, coyne and bergelson describe an "open sesame!" strategy developed by coxsackieviruses to invade the organism through the intestinal epithelium. the strategy involves coopting intrinsic signaling abilities of the apical gpi-anchored protein daf to open the tight junction barrier, gain access to the primary receptor car, and activate virus internalization by a caveolin-dependent pathway. | 2006 | 16459291 |
| insulin-lowering agents inhibit synthesis of testosterone in ovaries of dhea-induced pcos rats. | insulin-lowering agents are reported to be useful in treating polycystic ovary syndrome (pcos) anovulation. it has been suggested that lower insulin levels secondarily affect ovarian tissue, although the direct mechanism of action has not yet been verified. here we investigated if these agents directly affect the ovary. | 2006 | 16479139 |
| dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats. | the interaction of sesamin, one of the most abundant lignans in sesame seed, and highly purified docosahexaenoic acid (dha) or eicosapentaenoic acid (epa) in the form of ethyl ester in affecting hepatic fatty acid oxidation was examined in rats. in the first experiment, 3 groups of rats were fed with purified experimental diets free of n-3 fatty acid ethyl ester and containing 0%, 0.2%, and 0.4% sesamin (1:1 mixture of sesamin and episesamin), and 2 groups of animals were fed with a 2% dha ethyl ... | 2006 | 16483883 |
| toxic effects of methoxychlor on the episodic prolactin secretory pattern: possible mediated effects of nitric oxide production. | this work addresses the issue of whether methoxychlor (mtx) exposure may modify the ultradian secretion of prolactin through changes in the synthesis of nitric oxide (no) induced by nomega-nitro-l-arginine methyl ester (l-name) in the hypothalamic-pituitary axis. associated changes in dopamine (da) content in the anterior (ah), mediobasal (mbh) and posterior hypothalamus (ph) and median eminence (me) were evaluated. | 2006 | 16515688 |
| intraprostatic lymphocyte profiles in aged wistar rats with estradiol induced prostate inflammation. | we report ls phenotypes in aged wistar rats (charles rivers, wilmington, massachusetts) with epi. | 2006 | 16516042 |
| modifying effect of dietary sesaminol glucosides on the formation of azoxymethane-induced premalignant lesions of rat colon. | sesame, which has been reported to have preventive effects against various disordered conditions, contains small quantities of lignans and several precursors to them such as sesaminol glucosides (sg). the lignans have the potent antioxidative activity and are suggested to have chemopreventive property. in the present study, we evaluated the modulating effect of sg on the development of colon precancerous lesions, aberrant crypt foci (acf) and beta-catenin-accumulated crypts (bcac), in the azoxym ... | 2007 | 16517058 |
| novel depots of buprenorphine have a long-acting effect for the management of physical dependence to morphine. | buprenorphine is a promising new pharmacotherapy for the management of physical dependence to opioids. the aim of the study was to evaluate the duration of action of several novel depots of buprenorphine in the treatment of physical dependence to morphine in mice. following intramuscular injection, the duration of action of several novel oil-based depots of buprenorphine base in morphine-dependent mice were evaluated. the traditional dosage form of buprenorphine hydrochloride in saline was used ... | 2006 | 16536900 |
| evaluation of 5 new media containing extracts of seeds applied to candida dubliniensis screening. | candida dubliniensis is a recently described pathogenic species that shares many phenotypic features with candida albicans and so may be misidentified in microbiologic laboratories. the aim of this study is to find a useful and cost-effective method suitable for screening c. dubliniensis before proceeding to further identification. we examined the colony morphology and chlamydospore production of 26 c. dubliniensis isolates and 100 c. albicans isolates on the following 5 proposed media: sesame s ... | 2006 | 16545931 |
| sesamin is one of the major precursors of mammalian lignans in sesame seed (sesamum indicum) as observed in vitro and in rats. | plant lignans occur in many foods, with flaxseed presently recognized as the richest source. some plant lignans can be converted by intestinal microbiota to the mammalian lignans, enterodiol and enterolactone, which may have protective effects against hormone-related diseases such as breast cancer. this study determined whether plant lignans in sesame seed, particularly sesamin, could be metabolized to the mammalian lignans. the total plant lignan concentration in sesame seed (2180 micromol/100 ... | 2006 | 16549449 |