Publications

mycobacterium fortuitum infection in a patient with chronic lymphocytic leukaemia.		2004	15461617
ventriculo-peritoneal shunt infection by mycobacterium fortuitum in an adult.		2004	15472442
species identification of mycobacteria in paraffin-embedded tissues: frequent detection of nontuberculous mycobacteria.	diagnosis of infections caused by mycobacteria, especially nontuberculous mycobacteria still represents a difficult task both in microbiology and pathology. the aim of this study was to determine the frequency of mycobacterial dna detectable by pcr in formalin-fixed paraffin-embedded tissues showing suspicious granulomatous lesions. a total of 190 archival specimens were analyzed, using a nested pcr protocol, which amplifies a fragment of the mycobacterial 65-kda heat-shock protein gene. restric ...	2005	15475934
the antimycobacterial components of hops (humulus lupulus) and their dereplication.	bioassay-guided fractionation of a hexane extract of strobile hops (humulus lupulus) was undertaken to isolate and characterize the antimycobacterial constituents using the fast-growing mycobacterial species mycobacterium fortuitum. activity was associated with a low polarity fraction and 1h nmr spectra indicated the presence of a fatty acid mixture with unsaturated components. gc-ms of the derivatives indicated the presence of palmitic, stearic and oleic acids with small quantities of lignoceri ...	2004	15478197
synthesis and antimicrobial activity of some netropsin analogues.	nine novel lexitropsins were synthesized by linking two netropsin-like moieties through three different dicarboxylic acids; 9,10-dihydro-2,7-phenanthrenedicarboxylic acid; [(3-[[(carboxymethyl)amino]carbonyl]benzoyl)amino]acetic acid and indole-2,5-dicarboxylic acid. the netropsin residues were modified by the use of n-isopentylpyrrole, 5-methylthiophene or 5-isopropylthiazole heterocyclic building blocks in place of the usual n-methylpyrrole. the compounds were tested against five gram-positive ...	2004	15505717
infections of the subcutis and skin of dogs caused by rapidly growing mycobacteria.	nine dogs with panniculitis due to rapidly growing mycobacteria (rgm) were examined over 17 years. dogs were two to 15 years; five were male, four were female. all were obese or in good condition. antecedent injury, typically a dog bite or vehicular trauma, could be identified in some patients, while one bitch had hyperadrenocorticism. infections involved different locations, although the cervicothoracic region, dorsum or flank were most often affected. patients were systemically well, apart fro ...	2004	15517689
non-tuberculous mycobacteria: patterns of isolation. a multi-country retrospective survey.	to collect data on non-tuberculous mycobacteria (ntm) isolated from clinical laboratories in different countries to establish: 1) whether the isolation of ntm was increasing, 2) which species were increasing, and 3) whether there was any pattern of geographical distribution.	2004	15527150
successive development of cutaneous polyarteritis nodosa, leucocytoclastic vasculitis and sweet's syndrome in a patient with cervical lymphadenitis caused by mycobacterium fortuitum.	mycobacterium fortuitum is a rapidly growing mycobacterium found in soil and water throughout the world. it can cause diseases in immunocompetent patients, usually resulting in localized skin and soft tissue infections. cervical lymphadenitis caused by m. fortuitum is rare. we report a 46-year-old woman in whom skin lesions of cutaneous polyarteritis nodosa, leucocytoclastic vasculitis and sweet's syndrome had successively developed before the diagnosis of cervical lymphadenitis caused by m. for ...	2004	15541094
dissection of phylogenetic relationships among 19 rapidly growing mycobacterium species by 16s rrna, hsp65, soda, reca and rpob gene sequencing.	the current classification of non-pigmented and late-pigmenting rapidly growing mycobacteria (rgm) capable of producing disease in humans and animals consists primarily of three groups, the mycobacterium fortuitum group, the mycobacterium chelonae-abscessus group and the mycobacterium smegmatis group. since 1995, eight emerging species have been tentatively assigned to these groups on the basis of their phenotypic characters and 16s rrna gene sequence, resulting in confusing taxonomy. in order t ...	2004	15545441
clinical and laboratory features of mycobacterium porcinum.	recent molecular studies have shown mycobacterium porcinum, recovered from cases of lymphadenitis in swine, to have complete 16s rdna sequence identity and >70% dna-dna homology with human isolates within the m. fortuitum third biovariant complex. we identified 67 clinical and two environmental isolates of the m. fortuitum third biovariant sorbitol-negative group, of which 48 (70%) had the same pcr restriction enzyme analysis (pra) profile as the hsp65 gene of m. porcinum (atcc 33776(t)) and wer ...	2004	15583300
molecular basis of intrinsic macrolide resistance in clinical isolates of mycobacterium fortuitum.	some clinical isolates of mycobacterium fortuitum are naturally resistant to macrolides, e.g. clarithromycin. thus, the aim of this study was to identify the gene(s) conferring this resistance.	2004	15590712
analysis of the precursor rrna fractions of rapidly growing mycobacteria: quantification by methods that include the use of a promoter (rrna p1) as a novel standard.	mycobacterial species are able to control rrna production through variations in the number and strength of promoters controlling their rrn operons. mycobacterium chelonae and m. fortuitum are members of the rapidly growing mycobacterial group. they carry a total of five promoters each, encoded, respectively, by one and two rrn operons per genome. quantification of precursor rrn transcriptional products (pre-rrn) has allowed detection of different promoter usage during cell growth. bacteria growi ...	2005	15629925
[pulmonary mycobacterium fortuitum infection with multiple nodular shadows in a healthy man].	we report a case of pulmonary mycobacterium fortuitum infection with multiple nodular shadows. a 52 year-old male was admitted complaining of fever and chest abnormal shadows. he didn't have pulmonary or systemic underlying diseases. chest radiograph and computed tomography scan showed multiple nodular shadows in the both lung fields. isoniazid, rifampicin and ethambutol were administered based on the presumptive diagnosis of tuberculosis. cultures of the sputum and bronchial washing fluid were ...	2004	15631109
[mastitis due to mycobacterium fortuitum in an hiv negative patient].	a case of a 39 year old hiv negative female patient with a mycobacterium fortuitum mastitis without previous pathogenic history is reported. she was treated on the bases of drug-susceptibility testing and bibliographic empirical evidence with kanamycin, doxicicline, ciprofloxacin and trimetoprim-sulfametoxazol. a complete remission of her lesions was obtained after 15 months of treatment. lesions due to this rapidly growing mycobacterium, diagnosis and treatment are commented.	2004	15637832
mycobacterium fortuitum infection after a brown bear bite.		2005	15695734
bilateral bronchiectasis and bronchiolitis at thin-section ct: diagnostic implications in nontuberculous mycobacterial pulmonary infection.	to determine frequency of nontuberculous mycobacterial (ntm) pulmonary infection in patients with bilateral bronchiectasis and bronchiolitis at chest computed tomography (ct) and whether ct findings are indicative of mycobacterium avium-intracellulare complex (mac) infection.	2005	15703315
versatile rhodococcus equi-escherichia coli shuttle vectors.	rhodococcus equi is an intracellular pathogen of macrophages, causing disease in young foals, humans, and sporadically other animals. although r. equi is easy to grow and manipulate, the analysis of virulence is hampered by a lack of molecular tools. this paper describes the development of a number of versatile plasmids for use in r. equi. plasmids prev2 and prev5 use origins of replication derived from the mycobacterium fortuitum plasmids pal5000 and pmf1. these plasmids and their derivatives a ...	2005	15723178
functional analysis and annotation of the virulence plasmid pmum001 from mycobacterium ulcerans.	the presence of a 174 kb plasmid called pmum001 in mycobacterium ulcerans, the first example of a mycobacterial plasmid encoding a virulence determinant, was recently reported. over half of pmum001 is devoted to six genes, three of which encode giant polyketide synthases (pks) that produce mycolactone, an unusual cytotoxic lipid produced by m. ulcerans. in this present study the remaining 75 non-pks-associated protein-coding sequences (cds) are analysed and it is shown that pmum001 is a low-copy ...	2005	15758215
pacemaker infection due to mycobacterium fortuitum.	pacemaker infection with mycobacterium fortuitum has not been reported previously. we describe a case of pacemaker generator pocket infection and intravascular lead endocarditis due to mycobacterium fortuitum. the entire pacing system was removed and the patient was treated successfully with a multidrug regimen for a total of 6 months.	2005	15773026
murine infection model for mycobacterium fortuitum.	mycobacterium fortuitum is an atypical, non-tubercular, pathogenic, rapidly growing mycobacteria. as very little is known about its virulence determinants, the absence of an animal infection model was always sorely felt. a reliable and reproducible murine infection model has been developed in which non-replicating persistence of 10(5) cfu/g tissue in kidney was observed when a standardised dosage inoculum of 5x10(7) cfu was injected intravenously. the tissue bacillary load was determined at regu ...	2005	15777648
mycobacterium fortuitum infection caused by a cat bite.		2005	15778755
mycobacterium peregrinum infection in a patient with aids.	the patient, a 30-year-old housewife, visited a nearby doctor in mid august 2002 because of weight loss and neck swelling. hiv tests done at the hospital were positive. she was referred to and admitted to our hospital on october 2 for detailed examination and treatment of the neck tumor. a coat of epithelial debris extended from the oral cavity to the pharynx and an abscess and a fistula were found in the left tonsil. after hospitalization, an abscess culture revealed the presence of acid-fast b ...	2005	15805720
mycobacteria in nail salon whirlpool footbaths, california.	in 2000, an outbreak of mycobacterium fortuitum furunculosis affected customers using whirlpool footbaths at a nail salon. we swabbed 30 footbaths in 18 nail salons from 5 california counties and found mycobacteria in 29 (97%); m. fortuitum was the most common. mycobacteria may pose an infectious risk for pedicure customers.	2005	15829204
detection of mycobacteria in aquarium fish in slovenia by culture and molecular methods.	thirty-five aquarium fish were investigated for the presence of mycobacteria by culture and molecular methods. the following species were examined: goldfish carassius auratus auratus, guppy poecilia reticulata, 4 three-spot gourami trichogaster trichopterus, dwarf gourami colisa lalia, siamese fighting fish betta splendens, freshwater angelfish pterophyllum scalare, african cichlid fish cichlidae spp., cichlid fish microgeophagus altispinosus, cichlid fish pseudotropheus lombardoi, blue streak h ...	2005	15900685
mycobacterium fortuitum bacteraemia in an immunocompromised patient.	a case of mycobacterium fortuitum bacteraemia in an immunocompromised patient confirmed by four positive serial blood cultures is reported here. the patient was a known case of acute lymphoblastic leukemia (all) on intensive chemotherapy. the source of bacteraemia was most probably a peripherally inserted vascular catheter. after initiation, of treatment with amikacin to which the strain was sensitive and clarithromycin and removal of the central line the patient's fever defervesced and repeat b ...	2005	15928448
effect of subinhibitory concentrations of ciprofloxacin on mycobacterium fortuitum mutation rates.	fluoroquinolones have found a place in the management of mycobacterial diseases including tuberculosis. it has been previously shown that subinhibitory concentrations of quinolones increase the mutation rate in escherichia coli and staphylococci. the purpose of this study is to extend this observation to mycobacteria and to quantify mutation rates.	2005	15956099
genome-wide rnai screen for host factors required for intracellular bacterial infection.	most studies of host-pathogen interactions have focused on pathogen-specific virulence determinants. here, we report a genome-wide rna interference screen to identify host factors required for intracellular bacterial pathogenesis. using drosophila cells and the cytosolic pathogen listeria monocytogenes, we identified 305 double-stranded rnas targeting a wide range of cellular functions that altered l. monocytogenes infection. comparison to a similar screen with mycobacterium fortuitum, a vacuola ...	2005	16020693
drosophila rnai screen reveals cd36 family member required for mycobacterial infection.	certain pathogens, such as mycobacterium tuberculosis, survive within the hostile intracellular environment of a macrophage. to identify host factors required for mycobacterial entry and survival within macrophages, we performed a genomewide rna interference screen in drosophila macrophage-like cells, using mycobacterium fortuitum. we identified factors required for general phagocytosis, as well as those needed specifically for mycobacterial infection. one specific factor, peste (pes), is a cd36 ...	2005	16020694
identification of members of mycobacterium avium species by accu-probes, serotyping, and single is900, is901, is1245 and is901-flanking region pcr with internal standards.	from mycobacterium avium species mycobacterium avium subsp. paratuberculosis (n=961), mycobacterium a. avium (n=677), mycobacterium a. silvaticum (n=5), and mycobacterium a. hominissuis (n=1566) were examined, and from mycobacterium tuberculosis complex m. tuberculosis (n=2), mycobacterium bovis (n=13), m. bovis bcg (n=4), and mycobacterium caprae (n=10) were examined. from other mycobacterial species mycobacterium intracellulare (n=60) and atypical mycobacteria (n=256) including mycobacterium f ...	2006	16061296
[resistance of mycobacterium fortuitum against varied physical factors and its survival in different surroundings].	to observe the resistance of mycobacterium fortuitum against some physical factors and its survival in different surroundings.	2001	16136908
breast implant infection with mycobacterium fortuitum group: report of case and review.	there has been a marked increase in the frequency with which breast prosthesis are being used, both for reconstructive and cosmetic purposes. although breast implant-related infections are uncommon, they are typically caused by bacterial skin flora, specifically staphylococcus aureus and the coagulase negative staphylococci. there have been infrequent reports of breast implant infection caused by the atypical mycobacteria. this report summarizes the case of a young female who underwent augmentat ...	2006	16171871
mycobacterial ecology of the rio grande.	this is the first study to characterize the environmental conditions which contribute to the presence and proliferation of environmental mycobacteria in a major freshwater river. over 20 different species of environmental mycobacteria were isolated, including the pathogenic m. avium and m. kansasii. species of the rapidly growing m. fortuitum complex were the most commonly isolated mycobacteria, and one-third of all isolates were not identified at the species level, even by 16s sequencing. pcr r ...	2005	16204480
[mechanism study on difference of biotransformation between mycobacterium fortuitum mf2 and mf96].	biotransformation difference between parent strain (mf2) and mutant strain (mf96) of mycobacterium fortuitum was observed. biotransformation with resting cells showed that the major products of biotransformation by both parent and mutant strains are delta4-androstenedione(4ad) and testosterone(ts). experiments with cell-free extract system showed that the proportion of 4ad/ts obtained from parent and mutant strains was almost same when enough nad+ and nadh were supplied in this system. it was su ...	2005	16245863
non-tuberculous mycobacteria disease as a cause of hospitalization in hiv-infected subjects.	the present study characterized and determined the prevalence of mycobacterial diseases (tuberculosis (tb) and non-tuberculous mycobacteria (ntm)) as a cause of hospitalization among hiv-infected subjects consecutively admitted to a large metropolitan hospital during 2001/2002.	2006	16290202
mycobacterial trehalose-containing glycolipid with immunomodulatory activity on human cd4+ and cd8+ t-cells.	protection against mycobacterium tuberculosis is based on cell-mediated immunity, most importantly involving cd4+ and cd8+ t-cell subsets. one of the key features of the tubercle bacillus is its cell envelope, characterized by extremely abundant and specific lipids. the cell-surface glycolipid 2,3-di-o-acyl-trehalose (dat) has been consistently found in m. tuberculosis strains. in this study, analysis of proliferation, activation markers and cytokine release was performed in human peripheral blo ...	2006	16300984
emergence of mycobacterium simiae in respiratory specimens.	temporal changes in epidemiology of non-tuberculous mycobacteria (ntm) infections have hardly been explored. frequency of isolation of different ntm species varies geographically. we aimed to determine whether the distribution of mycobacteria species isolated from respiratory specimens had changed from 1996 to 2003. we analysed data on 484 patient mycobacterial isolates from 23,483 respiratory specimens submitted to the laboratory of microbiology in a tertiary medical centre. the proportion of p ...	2005	16308217
in vitro activity of some beta-lactams in combination with dicloxacillin against mycobacterium fortuitum.		1989	16312429
[ulcerative lymphadenitis due to mycobacterium fortuitum in an aids patient].		2005	16324572
polyphasic characterization reveals that the human pathogen mycobacterium peregrinum type ii belongs to the bovine pathogen species mycobacterium senegalense.	mycobacterium peregrinum consists of two taxa: types i and ii. we evaluated 43 clinical type ii strains from throughout the united states. they were responsible for soft-tissue and bone infections, catheter-related infections, and possible pneumonitis. by carbohydrate utilization, they were indistinguishable from type i strains, being d-mannitol and trehalose positive. however, they had a distinct susceptibility pattern that included intermediate ciprofloxacin mics but low clarithromycin and dox ...	2005	16333077
potential risk of mycobacterium avium subspecies paratuberculosis spread by syrphid flies in infected cattle farms.	the syrphid eristalis tenax linnaeus (diptera: syrphidae) may be found in and around dung storage pits at cattle farms at various developmental stages of their life cycle. the purpose of this study was to investigate the occurrence of mycobacterium avium ssp. paratuberculosis in 1044 e. tenax samples at various developmental stages, as well as fresh and stored dung originating from nine cattle farms. mycobacterium fortuitum was isolated from one (1.5%) larva from the vicinity of three paratuberc ...	2005	16336300
stereospecificity of microbial hydrations of oleic acid to 10-hydroxystearic acid.	we recently described a simple method for ascertaining the stereochemical purities of hydroxy fatty acids (s. h. el-sharkawy, w. yang, l. dostal, and j. p. n. rosazza, appl. environ. microbiol. 58:2116-2122, 1992) based on the h-nuclear magnetic resonance spectral analysis of diastereomeric s-(+)-o-acetylmandelate esters of hydroxystearates. this report describes the stereochemistries of microbial hydrations of oleic acid to 10-hydroxystearic acid by nocardia aurantia (also known as rhodococcus ...	1993	16348853
isolation and identification of environmental mycobacteria in the mycobacterium bovis bcg trial area of south india.	the isolation profiles of environmental mycobacteria present in soil, water, and dust samples, and sputum samples of persons with symptoms of chest infection in the south indian mycobacterium bovis bcg (bacillus calmette-guérin) trial area were compared. isolates belonging to the mycobacterium avium-intracellulare-scrofulaceum complex were predominant in water, dust, and sputum samples and mycobacterium fortuitum-complex organisms were predominant in soil samples irrespective of the season of th ...	1994	16349305
helium-neon and nitrogen laser irradiation accelerates the phagocytic activity of human monocytes.	intracellular survival of mycobacteria within monocytes is a crucial stage in the pathogenesis of tuberculosis. the aim was to check intracellular survival of mycobacterium fortuitum within the human monocytes exposed to he-ne and nitrogen laser irradiation.	2005	16356149
isolation of mycobacterium septicum from the sputum of a patient suffering from hemoptoic pneumonia.	a rapidly growing mycobacterium was isolated in pure culture from the sputum of a 78-year-old woman suffering from hemoptoic pneumonia. the isolate exhibited an antimicrobial susceptibility pattern and a biochemical profile similar to that of mycobacterium septicum atcc 700731(t) and shared 100% 16s rrna gene sequence similarity with this type strain over 1480 bp. its partial rpob sequence shared 98.2% similarity with the latter species, suggesting the isolate was representative of a sequevar of ...	2006	16364605
characterization of tetracycline resistance mediated by the efflux pump tap from mycobacterium fortuitum.	the aim of this study was to characterize the efflux pump tap from mycobacterium fortuitum, to test its sensitivity to well known efflux inhibitors, to study the interaction between tetracycline and these compounds and to test the ability of these compounds to overcome efflux pump-mediated tetracycline resistance. for all these studies, we produced tap protein in mycobacterium smegmatis.	2006	16373429
host range of 14 mycobacteriophages in mycobacterium ulcerans and seven other mycobacteria including mycobacterium tuberculosis--application for identification and susceptibility testing.	the host range of well-characterized mycobacteriophages, such as d29 and tm4, has been determined, together with that of more recently isolated mycobacteriophages, in mycobacterium ulcerans, mycobacterium tuberculosis, mycobacterium bovis bcg, mycobacterium avium, mycobacterium marinum, mycobacterium scrofulaceum, mycobacterium fortuitum and mycobacterium chelonae. here, a set of virulent phages for m. ulcerans, a pathogen with a dramatic increase of incidence over the last decade, is demonstrat ...	2006	16388028
rapidly growing mycobacteria in king chulalongkorn memorial hospital and review of the literature in thailand.	rapidly growing mycobacteria (rgm) have emerged as important human pathogens that can cause a variety of diseases. thirty isolates of the pathogenic rgm were recovered from patients who attended king chulalongkorn memorial hospital during 1997 and 2003. there were 16 isolates of mycobacterium chelonae, ten isolates of m. fortuitum and four isolates of m. abscessus. clinical data was available in only nine patients (five males and four females) including six m. chelonae, two m. abscessus, and one ...	2005	16404850
successful treatment of severe mycobacterium fortuitum exit-site infection with preservation of the tenckhoff catheter.		2005	16411533
application of four molecular typing methods for analysis of mycobacterium fortuitum group strains causing post-mammaplasty infections.	a cluster of cases of post-augmentation mammaplasty surgical site infections occurred between 2002 and 2004 in campinas, in the southern region of brazil. rapidly growing mycobacteria were isolated from samples from 12 patients. eleven isolates were identified as mycobacterium fortuitum and one as mycobacterium porcinum by pcr-restriction digestion of the hsp65 gene. these 12 isolates, plus six additional m. fortuitum isolates from non-related patients, were typed by pulsed-field gel electrophor ...	2006	16441452
atypical mycobacterium furunculosis occurring after pedicures.	mycobacterium fortuitum complex are rapidly-growing nontuberculous mycobacteria found ubiquitously in the environment including, water, soil, dust, and biofilms. m fortuitum has been reported to cause skin and soft-tissue infections in association with nail salon footbath use during pedicures. four cases of m fortuitum complex furunculosis are reported that occurred after pedicures in the cincinnati, ohio/northern kentucky area. dermatologists and clinicians should consider mycobacterial infecti ...	2006	16488309
non-tuberculous mycobacteria masquerading as aspiration pneumonia in patients with gastrointestinal problems.	the association between non-tuberculous mycobacterial pulmonary disease and achalasia, although previously documented in the respiratory literature, is not well recognised generally. we present a case of a female who presents with weight loss, cough and radiological findings of aspiration pneumonia and achalasia. a discussion of mechanisms for this association are presented.	2006	16500097
delayed post-operative wound infections due to non-tuberculous mycobacterium.	the non-tuberculous mycobacteria (ntm) have emerged as important opportunistic pathogens of human beings in the recent years. the ntm are rapid growing mycobacteria (rgm), which include mycobacterium fortuitum and m. chelonae and grouped as m. fortuitum-chelonae complex. though there are reports on isolation of ntm from various parts of india, information on its occurrence in northeastern india is lacking. we therefore undertook this preliminary investigation to report on the occurrence of ntm-a ...	2005	16518006
chronic cutaneous disease caused by the rapid growers mycobacterium fortuitum and chelonae.		2006	16536829
[mycobacterium fortuitum: a rare cause of pacemaker infection].		2006	16545324
synthesis and antileprosy activity of some dialkyldithiocarbamates.	to investigate the antileprosy potential of a set of original compounds with antimycobacterial activity.	2006	16595643
description of mycobacterium conceptionense sp. nov., a mycobacterium fortuitum group organism isolated from a posttraumatic osteitis inflammation.	a nonpigmented rapidly growing mycobacterium was isolated from wound liquid outflow, bone tissue biopsy, and excised skin tissue from a 31-year-old woman who suffered an accidental open right tibia fracture and prolonged stay in a river. the three isolates grew in 3 days at 24 to 37 degrees c. 16s rrna sequence analyses over 1,483 bp showed that they were identical and shared 99.7% (4-bp difference) sequence similarity with that of mycobacterium porcinum, the most closely related species. partia ...	2006	16597850
distribution of environmental mycobacteria in karonga district, northern malawi.	the genus mycobacterium includes many species that are commonly found in the environment (in soil and water or associated with plants and animals), as well as species that are responsible for two major human diseases, tuberculosis (mycobacterium tuberculosis) and leprosy (mycobacterium leprae). the distribution of environmental mycobacteria was investigated in the context of a long-term study of leprosy, tuberculosis, mycobacterium bovis bcg vaccination, and the responses of individuals to vario ...	2006	16597928
disseminated nontuberculous mycobacterial infection in a child with interferon-gamma receptor 1 deficiency.	we describe the case of a 2-year-old boy with disseminated infection by a rapidly growing, poorly pathogenic mycobacterial species that belonged to the mycobacterium fortuitum-mycobacterium peregrinum complex. he had a severe course characterized by a poor response to treatment and recurrent lymph node abscess formation. sequencing of the interferon-gamma receptor 1 gene (ifngammar1) revealed that he was homozygous for a novel null mutation, 453delt. patients presenting with disseminated infecti ...	2006	16602008
lower extremity furunculosis in a female adolescent.		2006	16645521
new antimycobacterial s-alkylisothiosemicarbazones.	in connection with a systematic study of antimycobacterial agents against potentially pathogenic strains the series of 12 s-alkylisothiosemicarbazones was evaluated for in vitro antimycobacterial activity against mycobacterium tuberculosis, m. kansasii, m. fortuitum, two strains of m. intracellulare and three strains of m. avium. quinoline-4-carbaldehyde-s-hexyl-isothiohydrazone was found to be more active against potentially pathogenic strains than isoniazide.	2005	16681143
atypical mycobacterial infection among hiv seronegative patients in pondicherry.	the role of non-tuberculous mycobacteria (ntm) as aetiological agents in the causation of lung infections has seldom been systematically studied from india.	2006	16696524
successful hematopoietic stem cell transplantation in a child with active disseminated mycobacterium fortuitum infection and interferon-gamma receptor 1 deficiency.		2006	16715106
serum igm levels against select marine bacteria in the atlantic sharpnose shark (rhizoprionodon terraenovae) from three estuaries.	the atlantic sharpnose shark (rhizoprionodon terraenovae) is abundant and easily captured throughout the southeastern united states. therefore this species serves as an ideal model for generating basic immunological reagents to establish baseline information regarding the immunophysiology of sharks in the wild, and for attempting to correlate shark immune responses to potential pathogens with the quality of the habitat in which they reside. sharpnose shark serum igm was purified over a protein-a ...	2006	16750427
mycobacterium fortuitum catheter-related sepsis in acute leukaemia.	we report mycobacterium fortuitum (m. fortuitum) catheter-related sepsis in a five-year-old boy with acute lymphoblastic leukaemia (all). this is the first reported case of m. fortuitum infection seen in our paediatric oncology patients. the patient was in haematological remission and receiving maintenance chemotherapy via an indwelling central venous catheter (port-a-cath). he was febrile, toxic-looking and was in respiratory distress. clinically, he had a right pleural effusion and gross hepat ...	2006	16752025
[soft-tissue infections due to non-tuberculous mycobacteria following mesotherapy. what is the price of beauty].	mesotherapy is widely used in latin america for cosmetic purposes, particularly in obese individuals. we describe the clinical and epidemiological characteristics, microbiological diagnosis, treatment and follow-up of patients from caracas (venezuela) with soft tissue infection caused by non-tuberculous mycobacteria following mesotherapy.	2006	16762255
[inactivation of mycobacteria by disinfectants with a tuberculocidal label].	disinfectants available in venezuela, registered as tuberculocidal, and used in clinical and laboratory settings were tested for their mycobactericidal activity.	2006	16762258
crystal structure of the mycobacterium fortuitum class a beta-lactamase: structural basis for broad substrate specificity.	beta-lactamases are the main cause of bacterial resistance to penicillins and cephalosporins. class a beta-lactamases, the largest group of beta-lactamases, have been found in many bacterial strains, including mycobacteria, for which no beta-lactamase structure has been previously reported. the crystal structure of the class a beta-lactamase from mycobacterium fortuitum (mfo) has been solved at 2.13-a resolution. the enzyme is a chromosomally encoded broad-spectrum beta-lactamase with low specif ...	2006	16801434
new antimycobacterial 2,3-dihydro-1-alkylindole-2-thiones.	a series of 2,3-dihydroindole-2-thiones was evaluated for in vitro antimycobacterial activity against mycobacterium tuberculosis, m. kansasii, m. fortuitum, two strains of m. intracellulare and three strains of m. avium. 2,3-dihydro-1-methyl-2-thioxoindole-3-one and 2,3-dihydro-1-butyl-2-thioxoindole-3-one were the most active substances against potentially pathogenic strains, being more active than isoniazide.	2006	16821707
mycobacterium fortuitum group periprosthetic joint infection.	the mycobacterium fortuitum group of rapidly growing mycobacteria is recognized infrequently as a cause of periprosthetic joint infection. this report describes a case of periprosthetic joint infection due to a member of the m. fortuitum group where failure to consider this pathogen caused months of diagnostic delay. aggressive surgery and 6 months of combination antimicrobial therapy eradicated the infection.	2006	16857632
delayed recognition of a pseudo-outbreak of mycobacterium terrae.	pseudo-outbreaks of mycobacteria are difficult to recognize because of long incubation periods for growth and species identification. we report our experience with one clinical microbiology laboratory that isolated a species of nontuberculous mycobacteria from 14 patient specimens. these specimens came from 12 patients at 2 hospitals over a 6-day period and included 6 different fluids or tissues. because of the delay between mycobacterial specimen submission and growth in culture, the outbreak w ...	2006	16877101
on an aspect of calculated molecular descriptors in qsar studies of quinolone antibacterials.	the re-emergence of tuberculosis infections, which are resistant to conventional drug therapy, has steadily risen in the last decade and as a result of that, fluoroquinolone drugs are being used as the second line of action. but there is hardly any study to examine specific structure activity relationships of quinolone antibacterials against mycobacteria. in this paper, an attempt has been made to establish a quantitative structure activity relationship modeling for a series of quinolone compoun ...	2006	16896544
exogenous lipoid pneumonia superinfected with acid-fast bacilli in infants: a report of nine cases.	super-infection of an exogenous lipoid pneumonia by nontuberculous mycobacteria has been described in the literature. it produces a distinctive histologic picture with suppurative, noncaseating granulomas surrounding lipid vacuoles containing acid-fast bacilli. mainly isolated cases have been found, but seldom in children. we describe a series of 9 children with similar histological findings. all our patients were under 1 year of age, malnourished, and with chronic respiratory symptoms. the diag ...	2006	16908460
an unusual presentation of mycobacterium fortuitum: massive isolated empyema in a patient with hiv.		2006	16926829
an outbreak of mycobacteriosis in gouldian finches caused by mycobacterium peregrinum.	an outbreak of mycobacteriosis was detected in an aviary containing gouldian finches (erythrura gouldiae) and golden shouldered parrots (psephotus chrysopterygius). affected birds developed granulomatous lesions, usually of the liver and intestine. mycobacterium peregrinum, a species of the mycobacterium fortuitum group, was cultured on pooled samples of intestinal tract from 31 euthanized finches. these rapid-growing mycobacteria are saprophytic organisms that are generally not associated with ...	2006	16931368
quantitative structure-activity relationship (qsar) studies of quinolone antibacterials against m. fortuitum and m. smegmatis using theoretical molecular descriptors.	the incidence of tuberculosis infections that are resistant to conventional drug therapy has risen steadily in the last decade. several of the quinolone antibacterials have been examined as inhibitors of m. tuberculosis infection as well as other mycobacterial infections. however, not much has been done to examine specific structure-activity relationships of the quinolone antibacterials against mycobacteria. the present paper describes quantitative structure-activity relationship modeling for a ...	2007	16932890
novel streptomycin resistance gene from mycobacterium fortuitum.	we have isolated the aph(3")-ic gene, encoding an aminoglycoside 3"-o-phosphotransferase [aph(3")-ic], from a genomic library of an environmental mycobacterium fortuitum strain, selecting for streptomycin resistance. aph(3")-ic phosphorylates and inactivates streptomycin. similar genes have been described in streptomyces griseus and plasmid rsf1010. it is also present in some m. fortuitum clinical isolates.	2006	16954315
successful treatment of a widespread cutaneous mycobacterium fortuitum infection with levofloxacin.		2006	16961521
[a case of pulmonary mycobacterium fortuitum infection successfully treated with kampo treatments].	a 72-year-old male was referred to our hospital in august 2001 for his pulmonary m. fortuitum infection. his symptoms were coughing, pyrexia, hemoptysis, general malaise, and insomnia. he had been suffering from these symptoms since 1982, though the intensive anti-mycobacterial chemotherapy such as three-drug (rfp, sm, and inh), twice two-drug (km and sm and cycloserine and enviomycin) and four-drug (cam, eb, rfp, and km) regimens were administered for 26 months from july 1999. his symptoms tent ...	2006	16972656
antimycobacterial activity of geranylated furocoumarins from tetradium daniellii.	seven geranylated furocoumarins were isolated from the fruits of tetradium daniellii (benn.) t.g. hartley (rutaceae) and tested for their antimycobacterial activity against mycobacterium fortuitum, m. smegmatis and m. phlei. they were shown to be highly active, with minimal inhibitory concentrations (mics) ranging from 8 to 64 microg/ml. xanthotoxin and xanthotoxol, representing furocoumarins lacking the lipophilic geranyl side chain, were tested similarly and were shown to be inactive. geraniol ...	2006	16981128
in vitro activities of the novel oxazolidinones da-7867 and da-7157 against rapidly and slowly growing mycobacteria.	da-7867 and da-7157 are oxazolidinones active against pathogenic aerobic actinomycetes including nocardia spp. and mycobacterium tuberculosis. however, the activity of these drugs against nontuberculous mycobacterium (ntm) species is not known. in this work, we compared the susceptibilities of 122 clinical isolates and 29 reference species of both rapidly growing and slowly growing mycobacteria to linezolid, da-7867, and da-7157 by the broth microdilution method. the mics for 50 and 90% of the s ...	2006	17015632
pacemaker infection due to mycobacterium fortuitum: the role of universal 16s rrna gene pcr and sequencing.	rapidly growing mycobacteria are a rare cause of pacemaker infection. a low index of suspicion and conventional diagnostic methods may delay diagnosis. we present a review of the literature and report a case of pacemaker infection due to mycobacterium fortuitum rapidly detected by universal 16s rrna gene polymerase chain reaction and sequencing.	2007	17020794
disseminated nontuberculous mycobacterial infections in sickle cell anemia patients.	nontuberculous mycobacteria (ntm) are ubiquitous in nature and have been implicated in skin/soft-tissue, pulmonary, middle ear, bone, and surgical/traumatic wound infections. disseminated disease occurs infrequently and almost exclusively in the immunocompromised. we describe the first 2 reported cases of disseminated mycobacterium fortuitum infection in teenagers with sickle hemoglobinopathy. both had central venous catheters (cvcs), frequent admissions for vaso-occlusive painful episode and re ...	2006	17023829
environmental mycobacteria in areas of high and low tuberculosis prevalence in the islamic republic of iran.	this research compared the numbers and types of different mycobacterium species in soil samples taken from 2 areas of golestan province, islamic republic of iran, 1 with a high prevalence of tuberculosis and 1 with a low prevalence. from 220 samples, 91 grew positive cultures (41.4%) and 161 different strains were diagnosed. the most common species isolated were mycobacterium fortuitum, m. flavescens and m. chelonae. the frequencies of environmental mycobacterium in the low-prevalence area were ...	2006	17037695
skin and soft tissue infections due to rapidly growing mycobacteria: comparison of clinical features, treatment, and susceptibility.	to compare the demographics, clinical features, susceptibility patterns, and treatment for skin and soft tissue infections due to mycobacterium fortuitum and mycobacterium chelonae or mycobacterium abscessus.	2006	17043183
[a case of mycobacterium fortuitum meningitis following surgery for meningioma].	a 57-year-old woman had undergone surgery for meningioma. after the surgery, she suffered from repeated fever and headache. one year after surgery, she was admitted to our hospital for further examination. cerebro-spinal fluid (csf) findings indicated bacterial meningitis infection. germ culture, acid-fast bacterium culture, pcr for mycobacteriosis and cryptococcus antigens as well as cytological examination of csf were checked repeatedly. however, all examinations were negative and etiology was ...	2006	17061701
a patient with relapsing pacemaker infection due to "gram-positive bacilli".	mycobacterium fortuitum infection of pacemaker system is rarely encountered in clinical practice. we reported a case of relapsing m. fortuitum infection of pacemaker system associated with endocarditis which had been erroneously diagnosed to be gram-positive bacilli. the diagnosis was finally confirmed by detail histological and microbiological examination. this case clearly demonstrated that incomplete removal of pacemaker system resulted in relapsing infection despite appropriate antibiotic th ...	2007	17070607
[mycobacterium fortuitum infection caused by the organism in subcutaneous abscess mediated by central venous catheter].	a 49-year-old woman with a mycobacterium fortuitum bloodstream infection, who has been managed with central venous (cv) catheterization for two years, was reported. she had undergone rectectomy for rectal cancer and gastectomy for stomach cancer at the ages of 36 and 42, respectively. also, she had undergone adhesiotomy for four times for postoperative ileus at the ages between 44 and 47. she was admitted to our hospital because of fever (38.4 degrees c) with chill and fatigue, and a subcutaneou ...	2006	17094583
utility of gas chromatography for rapid identification of mycobacterial species frequently encountered in clinical laboratory.	over the last years, the clinical importance of mycobacteria has been raised. in this regard, it is important their identification in order to establish either the clinical significance or the appropriate therapy of the disease. biochemical tests are usually time consuming until the report of results, that is why more rapid techniques are needed. as an alternative identification method, we have used a commercially available system for microbial identification based on whole cellular fatty acids ...	2007	17098312
multiple infections after commercial renal transplantation in india.		2007	17132708
native double-valve endocarditis by mycobacterium fortuitum following percutaneous coronary intervention.	infective endocarditis caused by atypical mycobacteria, especially mycobacterium fortuitum, is rare. most reported cases involve diseased valves or prosthetic heart valves. only four cases of native valve endocarditis caused by this organism have been previously reported. herein is reported a case of native valve endocarditis caused by m. fortuitum; the epidemiology and management of this rare cause of culture-negative endocarditis is discussed.	2006	17152794
mycobacterium fortuitum infection complicating infliximab therapy in rheumatoid arthritis.		2006	17207395
nontuberculous mycobacterial breast implant infections.	for reasons that are unclear, the incidence of nontuberculous mycobacterial disease is increasing worldwide. periprosthetic nontuberculous mycobacterial infections following augmentation mammaplasty and breast reconstruction have been reported previously in the form of case reports.	2007	17255691
comparative evaluation of the in vitro antimycobacterial activities of six aminoglycoside antibiotics using an agar dilution method.	given the increasing prevalence of mycobacterial resistance to aminoglycoside antibiotics, we examined the susceptibility of 76 clinical isolates of mycobacteria to arbekacin, amikacin, gentamicin, kanamycin, tobramycin and streptomycin using an agar dilution method. only arbekacin and amikacin showed excellent therapeutic potential (minimum inhibitory concentrationis (mics) < or =0.25-4 microg/ml) against 30 isolates of rapidly growing mycobacteria, including mycobacterium fortuitum, m. chelona ...	2006	17267338
effects of glutathione and n-acetyl cysteine on the antimycobacterial efficacy of isoniazid on mycobacterium fortuitum in vitro.		2006	17267348
in vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in taiwan.	the in vitro activities of isepamicin against 117 mycobacteria abscessus, 48 mycobacterium fortuitum, and 20 mycobacterium chelonae isolates were evaluated by a microdilution test. isepamicin mic(90)s were < or =16 microg/ml for the three species. isepamicin was as active as amikacin and kanamycin and more active than tobramycin, capreomycin, gentamicin, and streptomycin.	2007	17353252
atypical mycobacterial spondylitis in hiv-negative patients identified by genotyping.	non-tuberculous mycobacterial infections pose a significant diagnostic and therapeutic challenge. we report two cases of such infection of the spine in hiv-negative patients who presented with deformity and neurological deficit. the histopathological features in both specimens were diagnostic of tuberculosis. the isolates were identified as mycobacterium intracellulare and m. fortuitum by genotyping (microseq 16s rdna full gene assay) and as m. tuberculosis and a mycobacterium other than tubercu ...	2007	17356147
unusual clinical presentation of mycobacterium fortuitum infection in an immunocompetent woman.	the mycobacterium fortuitum group of rapidly growing nontuberculous mycobacteria is an uncommon cause of renal infection, particularly in otherwise healthy hosts. we describe a case of nephritis due to m. fortuitum in an immunocompetent woman with a clinical and radiological diagnosis of renal tuberculosis.	2007	17360837
[in-vitro activity of two hybrid synthetic peptides having antimicrobial activity against mycobacteria].	the increase in both mycobacterium tuberculosis human clinical isolates resistant to the essential drugs and cases of disseminated micobacteriosis due to mycobacterium avium complex, underlines the need to investigate new antimicobacterial agents. the antimicrobial peptides are a new group of active antibiotics with a particular mechanism of action. some of them, like cecropin and melittin, isolated from insects, have demonstrated good in vitro activity against gram-positive and gram-negative ba ...	2006	17370578
mycobacterium fortuitum-induced persistent parotitis: successful therapy with clarithromycin and ciprofloxacin.	parotitis caused by nontuberculous mycobacteria, a very rare disease entity, has never been reported to be caused by mycobacterium fortuitum (m. fortuitum) in the literature.	2007	17427970
infection of polypropylene threads for face-lifting with mycobacterium fortuitum.		2007	17430386