Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| increased prevalence of human papillomaviruses in the lower genital tract of pregnant women. | in order to evaluate the influence of pregnancy on the presence of human papillomavirus (hpv) in the lower female genital tract, cervical smears of 92 pregnant and 96 non-pregnant women, matched by age, were examined for the presence of hpv-dna by means of southern blot hybridization. all patients had negative pap smears. twenty-six (28%) of the pregnant women and 12 (12.5%) of the non-pregnant women were positive for hpv. hpv 16 accounted for 42% of all positive pregnant cases and only 25% of t ... | 1987 | 3038757 |
| the nucleotide sequence and genome organization of bovine papillomavirus type 4. | the nucleotide sequence of bovine papillomavirus type 4 (bpv-4) was determined. the viral genome is 7261 base pairs long. several overlapping open reading frames (orfs) have been identified both on the basis of amino acid comparison with other papillomaviruses and on their transcriptional pattern. eight early orfs (e1 to 8) were recognized, coding for dna replication and cell transformation functions, and three late orfs (l1 to 3), coding for structural proteins. like the e5 orf of human papillo ... | 1987 | 3039043 |
| oral human papillomavirus infections. | 1987 | 3039681 | |
| molecular analysis of integrated human papillomavirus 16 sequences in the cervical cancer cell line siha. | human papillomavirus (hpv) 16 is frequently found integrated into cervical cancer cell genomes and these integrations are thought to play a role in tumorigenesis. to investigate the mechanisms of hpv integration and its effect on transcription and chromosomal sequence organization, we have cloned and analyzed the hpv16 integration from the cervical cancer cell line siha. restriction analyses and southern blotting indicated that approximately 95% of an hpv16 genome was integrated without gross re ... | 1987 | 3039733 |
| [vulvar cancer originating from pointed condylomas--case report]. | a vulvar cancer is demonstrated. its origin from condylomata acuminata is discussed. the ultrastructural evidence of papillomavirusparticles within the nucleus of koilocytes are hints at a possible human papillomavirus etiology of vulvar carcinoma. because of the malign transformation of condylomata acuminata described we recommend a consequent treatment and histologic examination of condylomata acuminata. | 1987 | 3039758 |
| perinatal viral infections. | in comparison to older children and adults, neonates are immunologically incompetent. they are susceptible to infections caused by a variety of microorganisms, including bacteria, fungi and viruses. these infectious agents may be acquired by neonates either prenatally, during the intrapartum period or postnatally. the purpose of this review is to emphasize the potential impact of viral infections contracted by neonates at the time of delivery or within the neonatal period. the viruses reviewed i ... | 1987 | 3040392 |
| integration of human papillomavirus type 16 dna sequences: a possible early event in the progression of genital tumors. | the keratinocyte line sk-v harbors only integrated human papillomavirus type 16 (hpv 16) dna sequences, although it originated from vulvar bowenoid papules predominantly containing multiple copies of free hpv 16 genomes. we have cloned a fragment of cell dna that contains the integrated hpv 16 dna sequences and have shown that integration interrupts the hpv 16 genome in open reading frames e2 and l2 and creates a deletion of 813 base pairs. this allows the expression of open reading frames e6 an ... | 1987 | 3041049 |
| interferons in the treatment of genital human papillomavirus infections. | three major classes of interferons have been identified (alpha, beta, and gamma). all three have been tested in clinical trials in condylomata acuminata, or genital warts, with positive results. administration by topical, intralesional, intramuscular, and subcutaneous routes results in regression of human papillomavirus genital disease. significant reduction in measurable lesions occurs in some patients within days of initiation of therapy. responses appear to be both time and dose dependent. al ... | 1988 | 3044081 |
| somatic deletions and mutations of c-ha-ras gene in human cervical cancers. | the c-ha-ras-1 locus was analysed in cervical cancers and shown to exhibit the loss of one allele in 36% of heterozygous tumours and a mutation at codon 12 in 24% of tumours at advanced stages. 40% of tumours with mutation contained also a deletion. a c-myc gene activation was found in 100% and 70% of tumours containing mutation and deletion respectively. this suggests that the two proto-oncogenes cooperate for the progression of cervical cancers. furthermore as more than 90% of these tumours co ... | 1988 | 3060795 |
| role of epidermal langerhans cells in viral infections. | langerhans cells function as highly potent antigen-presenting cells in the epidermis. in the last few years, their role in viral infections has been studied in various experimental systems. they have been shown to be involved in the pathogenesis of a number of infections of viral origin. these include vaccinia virus, human papilloma virus, herpes simplex virus, foot and mouth disease virus and human retrovirus infections. studies on the effect of various factors, that are known to modulate the a ... | 1988 | 3063231 |
| treatment of recurrent squamous papillomata of the conjunctiva by carbon dioxide laser vaporization. | complete resection of recurrent conjunctival squamous papillomata frequently may be exceedingly difficult, since such lesions are typically friable and multilobulated. recurrent lesions often fill the fornicies and spill onto the lid margins. moreover, since the human papillomavirus (hpv) has been linked to some of these lesions, there remains the further possibility of spread with "cold knife" resection. we discuss the benefits of carbon dioxide laser vaporization therapy for recurrent squamous ... | 1986 | 3093950 |
| nuclear dna analysis of koilocytic and premalignant lesions of the uterine cervix. | cervical biopsy samples were taken from 79 patients who had various grades of cervical intraepithelial neoplasia or who showed evidence, in the form of koilocytosis, of human papillomavirus infection of the uterine cervix and from 10 women with normal cervices. the dna content of the cells in the samples was analysed by flow cytometry. analysis of the data obtained showed that the biopsy samples from women with cervical intraepithelial neoplasia and human papillomavirus lesions contained signifi ... | 1987 | 3101837 |
| [genital condylomas in women. treatment using a co2 laser: analysis of 141 cases]. | 141 patients who had lesions caused by human papilloma virus (hpv) in the vulva and vagina (63 cases) or in the cervix (78 cases) were routinely treated solely by using co2 laser. the lesions were vaporized when they were localised to the perineum and in certain selected cases in the cervix after they had been examined colposcopically and had biopsies taken. we resorted to conisation when lesions were not completely visible or when they were associated with cin iii (severe dysplasia and carcinom ... | 1988 | 3135302 |
| [a case of esophageal papillomatosis in adults]. | the authors report the case of a 60 year-old woman patient with esophageal papillomatosis, revealed by slowly progressive dysphagia and digestive hemorrhage. multiple warty tumors were found at endoscopy, starting at approximately 23 cm from the dental ridge, increasing in size into the lower esophagus where they were responsible for stenosis. pathological examination demonstrated epithelial proliferation with lengthened papillae, hyperkeratosis, hyperacanthosis and severe dysplasia. no extra-es ... | 1988 | 3280382 |
| predictive value of phenotypic cytologic characteristics in early dysplastic cervical lesions. | four phenotypic cytologic parameters (koilocytotic changes, binucleation, multinucleation and the presence of metaplastic dysplastic cells) were evaluated in the initial cervical smears from 89 women who presented with slight or moderate dysplastic changes and had an adequate follow-up. the cases were divided in two groups according to their evolution: the 51 cases constituting group i showed persistence or progression of the lesions while the 38 cases in group ii showed regression. koilocytosis ... | 1988 | 3287818 |
| monochloroacetic acid and 60% salicylic acid as a treatment for simple plantar warts: effectiveness and mode of action. | monochloroacetic acid crystals and 60% salicylic acid ointment was found to be more effective than placebo as a treatment for simple plantar warts in a double blind study on 57 patients. nineteen (66%) patients in the active treatment group compared with five (18%) patients in the placebo group were cured after 6 weeks (p = 0.002). the active treatment was associated with a significantly higher cure rate 6 months after entry (p = 0.04). treatments were well tolerated. igg or igm antibodies or bo ... | 1988 | 3377974 |
| results of carbon dioxide laser therapy and topical 5-fluorouracil treatment for subclinical condyloma found by magnified penile surface scanning. | previously we demonstrated a 68 per cent recurrence rate for subclinical penile human papillomavirus infections found by magnified penile surface scanning and treated with the carbon dioxide laser. in this report it is shown that the addition of a regimen of adjuvant topical 5-fluorouracil does not lower the recurrence rate. this knowledge combined with the evidence for a subclinical urethral reservoir of human papillomavirus implies that any strictly topical therapy will fail at 4 months of fol ... | 1988 | 3379696 |
| langerhans cells in epidermodysplasia verruciformis. | t cell defect and energy to contact sensitizers are characteristic of the depressed cell-mediated immunity in epidermodysplasia verruciformis (ev). in this disease the generalized infection with human papilloma viruses is associated with a high risk of skin cancers. langerhans cell density was studied quantitatively in lesions and noninvolved epidermis of ev using okt6 and anti-hla-dr monoclonal antibodies with indirect immunofluorescence technique. no significant changes were found in apparentl ... | 1987 | 3495461 |
| quantitative assessment of langerhans' cells in human cervical intraepithelial neoplasia and wart virus infection. | langerhans' cell density was assessed quantitatively in cervical wart virus infection (cervical condyloma), cervical intraepithelial neoplasia, and koilocytic dysplasia with use of an antibody to s100 protein and an indirect immunoperoxidase technique. when compared with normal ectocervix, langerhans' cell density was significantly decreased in cervical wart virus infection and significantly increased in cervical intraepithelial neoplasia. in koilocytic dysplasia, intermediate langerhans' cell d ... | 1986 | 3513580 |
| perianal bowen's disease associated with anorectal warts: a case report. | the occurrence of anogenital warts has increased both in clinic and in private practice. both sexes and all races are affected, with the highest prevalence in patients aged 15 to 40 years. the etiologic agent, the human papillomavirus (hpv), has been classified by dna hybridization techniques into at least 42 types, of which types 16 and 18 are considered to carry a high risk for cancer. a patient who had been seen intermittently over a period of 26 years with perianal and anal warts that respon ... | 1987 | 3563833 |
| carbon dioxide laser therapy of subclinical condyloma found by magnified penile surface scanning. | the etiology and treatment of condyloma caused by the human papilloma virus (hpv) and the association of hpv with cervical dysplasia and/or carcinoma is a major issue in current gynecologic literature. this study examined results of carbon dioxide (co2) laser treatment of 127 high-risk males with biopsy-proved subclinical hpv infections found by magnified penile surface scanning (mpss). at a mean follow-up of four months a 66 per cent recurrence rate of microscopic condyloma was encountered. a d ... | 1987 | 3576886 |
| gonorrhea and syphilis in incarcerated urban adolescents: prevalence and physical signs. | during a 1-year period from july 1983 to june 1984, 285 adolescent girls and 2,236 adolescent boys, ranging in age from 9 to 18 years (89% were 14 to 16 years of age), were screened for gonorrhea and syphilis on entry into a detention facility in new york city. the prevalence rate for gonorrhea was 3% for boys and 18.3% for girls, and the prevalence rate for syphilis was 0.63% for boys and 2.5% for girls. the rates of gonorrhea without penile or cervical discharge on physical examination were 2. ... | 1987 | 3658575 |
| [examination of condylomatous lesions of the uterine cervix in 468 anatomic specimens. retrospective study]. | on the basis of 468 anatomical specimens, we intended to look for histological signs of an hpv (human papilloma virus) infestation. this study has enabled to calculate the true incidence of this pathology, to correlate the histo-clinical aspects as well as the association severe lesions-condylomatous lesions. our conclusions confirm the close connection between viral lesions and malignant pathology of the cervix. | 1987 | 3671977 |
| condylomas of the uterine cervix initially interpreted as squamous carcinoma: a report of four cases including a lesion resembling the buschke-loewenstein giant condyloma. | the recognition of human papilloma virus (hpv)-induced cervicovaginal condylomatous lesions is in a period of dynamic development. it is estimated that condylomatous involvement of the uterine cervix is epidemic and that is particularly true in the younger, more sexually active woman. while cervical condylomas are often associated with cervical dysplasia, carcinoma in situ, or even invasive carcinoma, they are sometimes misdiagnosed as these entities. four cases of cervical condylomas are presen ... | 1986 | 3710268 |
| the pathology of vulvar squamous cell carcinoma and verrucous carcinoma. | squamous cell carcinoma is far more common than verrucous carcinoma in the vulva. the clinical and morphologic distinctions between these neoplasms are important to understand because of their contrasting biologic behavior and treatment. both cancers present with symptoms of pruritus and a noticeable mass. on examination, both tumors commonly occur on the labia and are exophytic. if infection occurs in association with verrucous carcinoma, the resulting induration of the surrounding tissue as we ... | 1986 | 3748617 |
| cytologic detection of condylomas and cervical intraepithelial neoplasia of the uterine cervix with histologic correlation. | human papillomavirus (hpv) has been implicated as an important etiologic factor in cervical carcinoma. this study evaluates the efficacy of cytology as a screening tool in the detection of cervical lesions with koilocytotic features. cervical smears and biopsy specimens from 76 women seen between january 1983 and october 1985 were reviewed. the histologic categories consisted of koilocytotic lesions (flat condylomas) with minimal cellular atypia, cin i, ii, iii, with surface koilocytes showing c ... | 1986 | 3756823 |
| many oncogenes are transcribed in the d98ah2 derivative of the hela carcinoma cell line. | as a first step in an ongoing study on the correlation of oncogene expression and tumorigenicity in hybrids made by fusing d98ah2 (d98) carcinoma cells with normal diploid human fibroblasts, we determined which oncogenes are expressed in the d98 cells. northern blot determinations of the rna levels of 21 oncogenes revealed moderate to abundant transcripts of 13 oncogenes. the remaining eight oncogenes for which no rna was found normally show a very restricted pattern of expression among cell typ ... | 1986 | 3780321 |
| condylomata acuminata arising in a neovagina. | a case is reported in which condylomata acuminata arose in a mcindoe neovagina. histopathologic and virologic evidence are provided to support the characterization of these lesions as benign warty processes secondary to human papillomavirus-6. factors influencing viral site specificity are discussed. | 1987 | 3808542 |
| diagnosis of cervical lesions from human papova virus. | the impact of human papillomavirus (hpv) infection in genital pathology has been clarified relatively recently and its relevance appears to be parallel to the liberalization of sexual customs. aside from some aspects of the infection grossly evident to the naked eye, an increasing number of sub-clinical lesions, that can be colposcopically identified as "flat condylomata" is commonly revealed by cytologic screenings. the authors report their experience in the diagnosis of this frequent pathology ... | 1985 | 3832715 |
| [epidemiologic factors in cervical intraepithelial neoplasia iii in our experience]. | the study of 52 cases of cervical intraepithelial neoplasia seen from 1980 to 1984 shows that early sexual activity increases the relative risk 3.35 times if the intercourse takes place before 20 years of age, and 2.5 times if before 15 years. the use of iud increases the risk 2.77 times. parity, civil status and gynecologic infections do not increase the risk. cervical intraepithelial neoplasia is more frequently diagnosed in women with a higher socio-economic status, due to a better health car ... | 1985 | 3880162 |
| skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells. | of 108 renal transplant recipients (53 men and 55 women) treated with azathioprine (0.8-2.9 mg/kg/day) and prednisolone (10 mg daily), 10 men had actinic keratoses, and five of these had squamous cell carcinoma, on light-exposed areas of skin. the time from transplantation to diagnosis of these skin lesions varied from 1.2 to 9.0 (mean 5.1) years. the concentration of the active azathioprine metabolite 6-thioguanine nucleotide was 120-425 (mean 276) pmol per 8 x 10(8) red blood cells in the tran ... | 1985 | 3913458 |
| progress toward the 1990 objectives for sexually transmitted diseases: good news and bad. | the problem of sexually transmitted diseases (stds) in the united states has been growing, in both scope and complexity, at an alarming rate. as evidence of the emergence of these diseases as a primary national concern, the surgeon general has designated them as 1 of 15 priority areas in which further actions are required to improve the health of the american people. the key targets for the 1990 objectives for the nation in the std area include reducing the incidence of gonorrhea; gonococcal pel ... | 1985 | 3923531 |
| improved laser techniques for the elimination of genital and extragenital warts. | two series of patients with genital warts were compared for effectiveness of treatment by means of the carbon dioxide laser. in the earlier series (1977 to 1981) laser vaporization was used to remove overt warts while surrounding normal skin was spared. examination of anal, urethral, and other extragenital sites for possible involvement was done only when warts persisted or recurred. in the later series (1983 to 1985), patients were similarly treated by carbon dioxide laser techniques; however, ... | 1985 | 4061516 |
| a study of human papilloma virus dna. | 1965 | 4286353 | |
| monoclonal antibodies to the major capsid protein of human papillomavirus type 1. | two stable monoclonal hybridoma cell lines secreting type-specific antibodies against the human papillomavirus type 1 (hpv-1) were isolated. the monoclonal antibodies detected hpv-1 antigens in frozen sections of hpv-1-induced warts, using immunofluorescence or immunoperoxidase techniques, and they reacted with hpv-1 particles in an immunodiffusion test. the two monoclonal antibodies recognized the major structural viral polypeptide, with a molecular weight of 54 000, and a minor polypeptide, wi ... | 1984 | 6086818 |
| the koilocyte and cervical intraepithelial neoplasia: time-trend analysis of a recent decade. | to determine whether the role of the human papillomavirus in the development of cervical intraepithelial neoplasia has changed recently, cervical biopsy specimens from the years 1972 and 1982 were reviewed to compare the frequency of diagnosis of human papillomavirus-associated koilocytosis in patients with suspected cervical intraepithelial neoplasia. no significant difference was found in the frequency of koilocytosis in biopsy specimens with cervical intraepithelial neoplasia between the year ... | 1984 | 6091461 |
| [cytologic diagnosis of cervico-vaginal infections with herpesvirus hominis type ii and human papilloma virus]. | 1984 | 6091487 | |
| molecular cloning and characterization of the genomes of nine newly recognized human papillomavirus types associated with epidermodysplasia verruciformis. | the genomes of 11 human papillomaviruses (hpvs) found in benign lesions of eight patients suffering from epidermodysplasia verruciformis were cloned in escherichia coli after insertion into plasmid pbr322. the study of the sensitivity of the cloned hpv dnas to 14 restriction endonucleases permitted the construction of physical maps. dna-dna hybridization experiments, performed under stringent conditions, showed that these viruses represent nine new types, hpvs 14 (with subtypes a and b), 15, 17 ... | 1984 | 6092701 |
| [focal epithelial hyperplasia (heck disease). contribution on its viral origin]. | demonstration of human papilloma virus dna (hpv-dna) in the lesions of focal epithelial hyperplasia in an 11-year-old turkish girl provides further proof of its viral cause. in this case characterization of hpv-dna showed a reaction with that of type 13 and 18. this previously undescribed variant is probably the expression of a new hpv type. | 1984 | 6094135 |
| cloning and characterization of papillomavirus type 2c dna. | human papillomavirus (hpv) dna was isolated from a clinically diagnosed flat wart and proved to be related to hpv2. the isolate showed 55% cross-hybridization with hpv2a. a physical map of restriction enzyme cleavage sites differed completely from those of hpv2a and hpv2b. the new hpv2 subtype, which will be classified as hpv2c, was found to be very prevalent in common warts. | 1984 | 6094390 |
| immunology of human papillomavirus: warts. | great progress has been made over the last five years in our understanding of papillomavirus (pv) biology. new technology has enabled investigators to understand the relationship between the pv and its host. the pv cannot be cultured in vitro, and this has led to limitations for those wishing to study the biology of this virus. however, utilizing recombinant dna technology, investigators now have abundant quantities of human papillomavirus (hpv) dna for study. such hpv genomes may be labeled wit ... | 1983 | 6095237 |
| human papillomavirus dna in genital tumours. | human papillomaviruses (hpv) types 16 and 18 have been identified in two different human cervical carcinomas. the viral dnas were molecularly cloned and used as probes to screen a large number of genital tumours by southern blot analysis. hpv 16 or hpv 18 sequences were found in a high percentage of cervical carcinomas but only in a small number of condylomata acuminata or flat condylomas. the majority of the latter lesions, however, contained hpv 6 or hpv 11 sequences, respectively, which, in c ... | 1984 | 6100278 |
| morphological and immunohistochemical evidence of human papilloma virus (hpv) involvement in the dysplastic lesions of the uterine cervix. | a series of 110 biopsies of the uterine cervix containing dysplastic and/or in situ changes were assessed morphologiccally with reference to presence or absence of the coexistent condylomatous lesions, and using the immunoperoxidase-pap technique to disclose the hpv (human papilloma virus) antigens in the cells. morphologically, 79 biopsies contained condylomatous (co) lesions (63 flat, 12 inverted and 4 papillomatous ones), and 31 were non-condylomatous (nco) dysplasias/in situ carcinomas. the ... | 1983 | 6141079 |
| langerhans cells in human papillomavirus (hpv) lesions of the uterine cervix identified by the monoclonal antibody okt-6. | the local inflammatory cell infiltrates in 263 cervical punch biopsies of the women followed-up since 1981 (16 +/- 14 months, mean +/- s.d.) for an established human papillomavirus (hpv) lesion with or without concomitant cervical intraepithelial neoplasia (cin) were analysed for occurrence of langerhans cells, defined by the monoclonal antibody okt-6 using the avidin-biotin peroxidase complex (abc) technique. okt-6+ cells remained at the constant low level (1.5-1.9% of the inflammatory cells) i ... | 1984 | 6151923 |
| human papilloma virus infection of the uterine cervix. | 1980 | 6243835 | |
| oral retinoid treatment of human papillomavirus type 5-induced epidermodysplasia verruciformis. | 1980 | 6245361 | |
| molecular cloning, refined physical map and heterogeneity of methylation sites of papilloma virus type 1a dna. | the entire genome of human papilloma virus type 1a was cloned in escherichia coli using the plasmid pbr322 as vector. the integrity and the homogeneity of the viral dna thus obtained was confirmed by restriction endonucleases analysis. viral dna isolated from a single wart was partially methylated at only one out of the four hpaii sites, d(c-c-g-g). recognition sites for bg/i, bg/ii, psti and pvuii restriction endonucleases were located on the cloned genome. | 1980 | 6250842 |
| a potentially oncogenic human papillomavirus (hpv-5) found in two renal allograft recipients. | we have observed 2 immunosuppressed renal allograft recipients with skin lesions induced by human papillomavirus type 5 (hpv-5). one recipient had multiple pityriasis versicolor-like (pv-like) skin lesions on his arms and trunk, and multiple bowenoid in-situ skin cancers. the other had 2 warty lesions on the back of her fingers. structural antigens of human papillomavirus type 5 (hpv-5) were identified in benign lesions from both patients by immunofluorescence. the histologic and ultrastructural ... | 1980 | 6253573 |
| cloning of human papilloma virus genomic dnas and analysis of homologous polynucleotide sequences. | the complete dna genomes of four distinct human papilloma viruses (human papilloma virus subtype 1a [hpv-1a], hpv-1b, hpv-2a, and hpv-4) were molecularly cloned in escherichia coli, using the certified plasmid vector pbr322. the restriction endonuclease patterns of the cloned hpv-1a and hpv-1b dnas were similar to those already published for uncloned dnas. physical maps were constructed for hpv-2a dna and hpv-4 dna, since these viral dnas had not been previously mapped. by using the cloned dnas, ... | 1980 | 6253665 |
| relationship between condylomata and laryngeal papillomata. clinical and molecular virological evidence. | in a survey of 49 papilloma patients accurate maternal condyloma history was obtained in 31 instances and of these, 21 were positive for the presence of condyloma during pregnancy or parturition. molecular virological studies indicate that positive hybridization could be demonstrated to human papilloma virus 2 in both laryngeal papilloma and condyloma by the southern blot technique. immunoperoxidase staining illustrated the presence of virus-related particles only near the surface of the mucous ... | 1980 | 6254426 |
| anogenital warts contain several distinct species of human papillomavirus. | anogenital warts from 26 patients were examined for the presence of human papillomavirus (hpv). although no whole, intact virus could be identified, varying amounts of nonintegrated hpv dna were detected in 18 tissue specimens (70%) by employing both an agarose gel-ethidium bromide staining method and the southern blot hybridization procedure. when hybridization analysis was performed under stringent conditions, six anogenital warts were observed to contain hpv genomic sequences related to eithe ... | 1980 | 6255208 |
| presence of human papilloma viral antigens in juvenile multiple laryngeal papilloma. | juvenile laryngeal papillomas, solitary laryngeal papillomas of the adult, and cylindric cell papillomas of the nose and sinuses were examined for the presence of papillomavirus antigens by means of immunocytochemistry. by using an antiserum capable of recognizing a common group antigen that reacts with papillomavirus antigens of different species, it was found that half of the juvenile laryngeal papillomas studied contained cells staining for papillomavirus antigens. no positive cells were foun ... | 1981 | 6258422 |
| immunoperoxidase localization of human papillomavirus in laryngeal papillomas. | five antigenically distinct serotypes of human papillomavirus (hpv) cause various cutaneous verrucae with distinct clinical features. laryngeal and other mucosal papillomas, also suspected to have a viral etiology, were examined for the presence of a genus-specific (common) antigen of hpv using a peroxidase-antiperoxidase (pap) technique. the primary antiserum used was reactive against laryngeal papillomas from 26 of 35 randomly selected patients (74%); overall, 49 of the 102 squamous papilloma ... | 1980 | 6263818 |
| histological evidence for the presence of condylomatous epithelial lesions in association with laryngeal squamous cell carcinoma. | the laryngeal specimens obtained from 116 patients with established invasive squamous cell carcinoma of the larynx were histologically assessed with special reference to the detection of morphological manifestations of human papilloma virus (hpv), as newly described in the uterine cervix, i.e. the three different types of condylomas (the papillomatous, the flat and the inverted ones). epithelial changes fulfilling the criteria of the papillomatous condyloma were found in 15 cases, those of the i ... | 1981 | 6265845 |
| human papilloma virus type i purified from human genital warts. | human wart virus (hpv) was isolated from a pool of genital warts. the electrophoretic mobility of virion proteins was studied by sds polyacrylamide gel electrophoresis and showed the same pattern as that obtained with hpv-1. the analysis of dna after restriction enzyme digestion with the endonucleases hind iii and hae iii, and nucleic acid hybridization did not show any difference with hpv-1. the viral particles were agglutinated by anti-hpv-1 serum, as shown by electron microscopic particle agg ... | 1981 | 6266889 |
| genital warts. | human papillomaviruses have not been propagated in tissue culture, so they cannot be studied by the procedures of classical virology. recently, dna hydridization techniques and restriction enzyme analysis have revealed that multiple strains of human papillomaviruses exist. it is now accepted that genital warts are a sexually transmitted disease; other routes of infection are possible, but unusual. an association between maternal warts during pregnancy and the development of vulval warts and lary ... | 1981 | 6277022 |
| vulvar intraepithelial neoplasia: correlation of nuclear dna content and the presence of a human papilloma virus (hpv) structural antigen. | immunoperoxidase localization of a human papilloma virus structural antigen (hpv) was attempted in 68 intraepithelial lesions of the vulva, 39 of which were analyzed for nuclear dna content by microspectrophotometry. overall, 5.9% (4/68) stained positive for hpv. ninety percent (35/39) of the cases tested were aneuploid, and, of these, 2.8% (1/35) stained positive for hpv. in contrast, 50% (2/4) of the polyploid lesions were positive. hence dna microspectrophotometry and immunoperoxidase localiz ... | 1982 | 6277449 |
| analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 dna. | 32p-labelled cloned hpv 6 dna was used as probe to analyze human genital tumors for dna sequences homologous to hpv 6 dna. ninety three percent of all condylomata acuminata (41 out of 44) were found to harbor hpv 6 dna. of the remaining three, one contained hpv 1 dna. no papillomavirus dna was identified in the two other tumors. all three invasively growing giant condylomata acuminata (buschke-löwenstein tumors) investigated also contained hpv 6 dna. two out of six atypical condylomata of the ce ... | 1982 | 6277807 |
| human papillomavirus dna in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis. | dna extracted from squamous cell carcinomas from patients with the chronic wart disease syndrome, epidermodysplasia verruciformis, was analyzed for the presence of human papillomavirus (hpv)-specific dna sequences by southern blot hybridization analysis. employing an hpv probe obtained by molecular cloning of viral dna purified from benign warts from these patients, we have unequivocally identified hpv-specific nucleotide sequences in squamous cell carcinomas from these patients. restriction end ... | 1982 | 6280194 |
| new human papilloma virus isolated from epidermodysplasia verruciformis lesions. | human papilloma virus (hpv) was isolated from red plaques of a patient (n. f.) with epidermodysplasia verruciformis. electron microscopic examination showed characteristic particles of papilloma virus as icosahedrons about 45 nm in diameter. dna was extracted from these particles, and closed-circular dna (form i) was purified by centrifugation in cscl containing ethidium bromide. the molecular weight of the dna was about 5.0 x 10(6). a physical map of the hpv dna was constructed using several re ... | 1982 | 6280858 |
| infections by human papillomavirus (warts). | 1982 | 6282150 | |
| genital warts and cervical cancer. i. evidence of an association between subclinical papillomavirus infection and cervical malignancy. | a blind comparative survey was undertaken to study the prevalence of subclinical papillomavirus infection (spi) in a representative sample of women treated surgically for invasive or preinvasive cervical neoplasia. according to a semiobjective rating system, 73 of 80 women (91%) with cervical neoplasia and ten of 80 matched controls (12.5%) showed histologic evidence of human papillomavirus (hpv) infection. sixty of the controls (75%), but none of the study group, had normal cervicovaginal epith ... | 1982 | 6282442 |
| a comparative study on ultrastructure and immunological properties of human papilloma virus before and after fixation. | 1982 | 6286744 | |
| demonstration of human papilloma virus antigen in the condylomatous lesions of the uterine cervix by immunoperoxidase technique. | routine histological sections of characteristic condylomas (showing dysplasia of different degrees) collected from the uterine cervix of 10 women were subjected to staining with indirect immunoperoxidase technique using antihuman papillomavirus (anti-hpv) serum to demonstrate the hpv antigens in these lesions. the anti-hpv immune serum was raised in guinea pigs immunized with highly purified viruses from a pool of skin wart lesions collected from various anatomical sites. 8 out of the 10 condylo ... | 1982 | 6288519 |
| human papilloma virus infection (condyloma) of the uterine cervix in japanese women. | 1982 | 6290429 | |
| viral etiology of juvenile- and adult-onset squamous papilloma of the larynx. | juvenile- and adult-onset laryngeal papillomas were examined for the presence of a human papillomavirus (hpv) genome and capsid antigens. dna was isolated from a portion of tissue removed for therapeutic purposes, and the presence of a papillomavirus genome was detected by southern transfer analysis. the viral dna found in the 12 juvenile-onset and the 8 adult-onset laryngeal papillomas examined was identified as hpv-6 on the basis of size, restriction endonuclease digestion patterns, and homolo ... | 1982 | 6291043 |
| cervical papillomavirus infection in diethylstilbestrol-exposed progeny. | histologic sections from cervical and vaginal biopsies showing dysplasia in 37 women exposed to diethylstilbestrol (des) in utero were stained for human papillomavirus structural antigens using an immunoperoxidase technique. forty-three percent of the lesions had detectable papillomavirus antigens. these findings indicate that a significant proportion of cervical dysplasia observed in des-exposed progeny is associated with papillomavirus infection. | 1983 | 6296741 |
| human papilloma virus 5-dna in a carcinoma of an epidermodysplasia verruciformis patient infected with various human papillomavirus types. | an epidermodysplasia verruciformis patient suffering from generalized warts and a carcinoma at the forehead was found to be infected by at least six types and subtypes of human papillomaviruses. the central part of the carcinoma, however, harbored only human papillomavirus 5 dna. the dna persisted extrachromosomally in high genome copy number. in contrast to wart dna preparations, a significant part of the viral sequences in the carcinoma was present as oligomers, at least part of them being con ... | 1983 | 6297727 |
| abnormalities of the uterine cervix in women with vulval warts. a preliminary communication. | fifty women attending a clinic for sexually transmitted diseases with vulval condylomata acuminata were examined by cervical cytology and colposcopy for cervical infection by human papillomavirus (hpv) or epithelial abnormality indicating cervical intraepithelial neoplasia (cin) or both. collated results showed a high prevalence of both conditions in these 50 women; 25 (50%) had evidence of cervical infection by hpv and 18 (36%) epithelial abnormalities consistent with cin 1 or 2. | 1983 | 6299450 |
| human papillomavirus types 6 and 11 dna sequences in genital and laryngeal papillomas and in some cervical cancers. | human genital tumors as well as recurrent laryngeal papillomas were analyzed for the presence of human papillomavirus (hpv) 6 and hpv 11 sequences. hpv 11 dna was found in 7 of 14 laryngeal papillomas; in the 7 other tumors no hpv dna was demonstrated. hpv 11 dna was also found in all five atypical condylomata of the cervix included in this study. condylomata acuminata mainly contained hpv 6 dna. from 63 biopsy specimens, 41 clearly harbored hpv 6 dna and 13 harbored hpv 11 dna. in three tumors ... | 1983 | 6300854 |
| human papilloma virus linked to cervical (and other) cancers. | 1983 | 6304359 | |
| a papillomavirus dna from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. | dna from one biopsy sample of invasive cancer of the cervix contained sequences hybridizing with human papillomavirus (hpv) type 11 dna only under nonstringent conditions. this dna was molecularly cloned in lambda phage. under stringent conditions of hybridization it cross-hybridized to a minor extent (less than 0.1%) with hpv types 10, 14, and 15 and showed no homology with dna of other human hpv types. we therefore propose to designate it tentatively as hpv 16. hpv 16 dna was used as a probe t ... | 1983 | 6304740 |
| human papillomavirus (hpv) involvement in squamous cell lesions of the oral cavity. | 1983 | 6306646 | |
| the prevalence of human papillomavirus antigen in patients with cervical intraepithelial neoplasia. | 1983 | 6307333 | |
| human papilloma virus in multifocal, invasive female genital tract malignancy. | two young patients with multifocal, invasive, verrucoid carcinomas of the lower genital tract are described. viral particles consistent with human papilloma virus were demonstrated by transmission electron microscopy in areas of koilocytotic malignant and nonmalignant epithelium, and both patients had evidence of impaired immune function. the role of human papilloma virus in genital neoplasia is discussed. | 1983 | 6308532 |
| oncological consequences of impaired immune surveillance against ubiquitous viruses. | the immune system is constantly challenged by ubiquitous viruses. multiple immune defenses have evolved to meet these challenges, and thus immunocompetent individuals successfully respond to infection without sequela. x-linked lymphoproliferative syndrome patients, renal allograft recipients, and acquired immunodeficiency syndrome patients share impaired immune surveillance as a common feature. such individuals are variously susceptible to numerous untoward complications following infection with ... | 1983 | 6309892 |
| natural history of cervical epithelial abnormalities in patients with vulval warts. a colposcopic study. | the natural history of intraepithelial abnormalities of the cervix associated with human papillomavirus infection was investigated in a prospective study of 50 women with vulval warts, of whom 28 had colposcopic evidence of a cervical epithelial abnormality and 22 a normal cervix. of the 28 with a cervical abnormality, 26 were re-examined by colposcopy after three months; the epithelial abnormality had persisted in 23 women. nineteen women who had initially shown abnormality by colposcopy were r ... | 1983 | 6311324 |
| characterization of human papillomavirus type 13 from focal epithelial hyperplasia heck lesions. | focal epithelial hyperplasia heck lesions of a turkish patient were shown to contain papillomavirus-specific dna, which was molecularly cloned into bacteriophage lambda. it proved to be related to human papillomavirus (hpv) type 6 dna and hpv type 11 dna. reassociation kinetics revealed a cross-hybridization of 4 and 3%, respectively. there was no cross-reactivity with hpv type 1, 2, 3, 4, 5, 8, or 10. this papillomavirus type will be referred to as hpv type 13. the dna was characterized by clea ... | 1983 | 6312071 |
| [clinical and histological characteristics of the changes induced by human papilloma virus (hpv 7)]. | 1982 | 6312492 | |
| identification of human papillomavirus dna in cervical and vaginal intraepithelial neoplasia with molecularly cloned virus-specific dna probes. | the presence of human papillomavirus (hpv) dna was identified in the tissues of cervical and vaginal intraepithelial neoplasia by southern blot dna hybridization under conditions of low stringency. the specific types of hpv present in the tissues were identified by using molecularly cloned types 1 through 6 (hpv-1 through hpv-6) hpv dna probes under high-stringency conditions. all tissues of cervical and vaginal intraepithelial neoplasia analyzed contained hpv genomes. fifteen of 19 samples (79% ... | 1983 | 6313534 |
| the story of a cell. the george n. papanicolaou award lecture. | the history of one cell type observed on gynecologic cytologic samples and later identified as pathognomonic of human papillomavirus (hpv) infection is presented. mention is also made of the role of hpv in the development of premalignant and malignant squamous lesions of the uterine cervix. | 1983 | 6316699 |
| human papillomavirus: detection of viral dna sequences and evidence for molecular heterogeneity in metaplasias and dysplasias of the uterine cervix. | colposcopic-directed biopsies of the uterine cervix from 22 patients were analyzed for the presence of human papillomavirus (hpv) dna and structural antigens. 11 of the biopsies were classified microscopically as mild dysplasia, 3 as moderate dysplasia, 1 as severe dysplasia, and 7 as squamous metaplasia. nonstringent hybridization with a bovine papillomavirus type 1 dna probe and immunocytochemical analysis with an antiserum against papillomavirus genus-specific structural antigens were perform ... | 1983 | 6317605 |
| association of human papillomavirus subtype and clinical course in respiratory papillomatosis. | the relationship of human papillomavirus type 6 (hpv-6) subtypes to the clinical manifestations of respiratory papillomatosis was investigated. dna was isolated from biopsy specimens of 21 patients and the viral genome analyzed by molecular hybridization. four subtypes, designated hpv-6c through hpv-6f, were distinguishable by restriction endonuclease cleavage patterns of the viral genome. patient records were reviewed to identify associations between viral subtype and sex, race, age at onset of ... | 1984 | 6318005 |
| human papillomavirus infection and cervical intraepithelial neoplasia: histopathology and dna content. | to evaluate the reliability of diagnostic criteria for separating intraepithelial squamous lesions into low- and high-risk categories, 25 lesions of the cervix were diagnosed as flat condyloma, atypical immature metaplasia, or cervical intra-epithelial neoplasia with koilocytosis based on well-defined histologic criteria. the presumption was that flat condyloma and atypical immature metaplasia would be diploid/polyploid as compared to low-grade cervical intraepithelial neoplasia, which should be ... | 1984 | 6318171 |
| human papillomavirus infection of the uterine cervix: histological appearances in 28 cases identified by immunohistochemical techniques. | twenty eight biopsy specimens of the cervix showed positive immunohistochemical staining when treated with an antiserum raised against an internal capsid antigen of human papillomavirus (hpv). histological examination of adjoining sections from the same blocks showed a much wider range of abnormalities than those already described in association with hpv infection. the picture was usually diagnostic. it rested chiefly on identifying the koilocyte--the cell with the perinuclear halo that carries ... | 1984 | 6319459 |
| bowenoid papulosis. demonstration of human papillomavirus (hpv) with anti-hpv immune serum. | two cases of bowenoid papulosis (bp) occurred. the presence of human papillomavirus was demonstrated in one patient. in the other patient, condyloma acuminatum developed after initial spontaneous improvement in his lesions. the discovery of a possible oncogenic virus in bp and the epidemiologic behavior of carcinoma in situ and multicentric carcinomas suggest the need for a very careful follow-up evaluation of such lesions. bowenoid papulosis may be a chronic dysplasia with a variable long-term ... | 1984 | 6322703 |
| human papillomavirus (hpv) venereal infections and gynecologic cancer. | 1983 | 6326025 | |
| presence of human papillomavirus in verrucous carcinoma (ackerman) of the vagina. immunocytochemical, ultrastructural, and dna hybridization studies. | human papillomavirus (hpv) genomes were identified in two cases of verrucous carcinoma of the vagina, using southern blot dna hybridization under low-stringency conditions. type (group) 6 hpv dna (hpv-6) was identified, using molecularly cloned hpv-1 through hpv-6 dna probes under high-stringency conditions in both cases. in addition, dna extract in one case hybridized with hpv-1, hpv-3, and hpv-4 dna probes. no hpv structural proteins were demonstrated in either case by immunocytochemical tests ... | 1984 | 6329128 |
| papillomavirus infection of the cervix. iii: relationship of the presence of viral structural proteins to the expression of involucrin. | forty-two cervical biopsies with cervical intraepithelial neoplasia were compared with respect to the expression of human papillomavirus (hpv) structural proteins and the expression of the cellular structural protein involucrin, a marker of suprabasal squamous differentiation. hpv structural protein and involucrin expression displayed an inverse correlation with the severity of dysplasia. both of these proteins were detected in 11 of 28 cases (39%) of mild and moderate dysplasia, but in only two ... | 1984 | 6329974 |
| papillomavirus genomes: sequences and consequences. | the complete nucleotide sequences of four papillomavirus genomes recently determined (human papillomavirus types 1a and 6b, bovine papillomavirus type 1, and the shope cottontail rabbit papillomavirus) shed light on the molecular genetics of these epitheliotropic viruses. the organization of the four genomes is very similar, and their comparative analysis suggests new hypotheses about the nature of the viral proteins, their involvement in virus structure, and their interaction with the host cell ... | 1984 | 6330226 |
| hsv, cmv, and hpv in human neoplasia. | we are studying the role of sexually transmitted viruses in the development of human tumors. the persistence of herpes simplex virus, cytomegalovirus, and human papillomavirus nucleic acid sequences has been examined using cloned viral dna sequences as probes. the relationship of the viruses to various stages in the progression of neoplasia is examined, with particular reference to the role of viral and/or cellular genes in the initiation, promotion, and maintenance of the neoplastic phenotype. ... | 1984 | 6330227 |
| the pathology of superficially invasive, thin vulvar squamous cell carcinoma. | thirty-six cases of vulvar squamous cell carcinoma 5 mm or less in thickness were studied, and potential predictors of lymph node metastases were evaluated. tumor thickness and depth of stromal invasion were measured. inguinal lymph node metastases were present in six (17%) cases, all of which had primary neoplasms more than 3 mm thick. the most superficial lesion to have lymph node metastasis was 3.2 mm thick and had 1.6 mm of stromal invasion. nonetheless, depth of stromal invasion of less tha ... | 1984 | 6511160 |
| [focal epithelial hyperplasia in lepromatous leprosy]. | focal epithelial hyperplasia heck (feh) is most likely caused by human papilloma virus. it mainly occurs in children and young people showing no associated diseases. for the first time, we describe a case of feh in a patient with lepromatous leprosy who due to persistent erythema nodosum leprosum has been treated with a lang-term glucocorticoid therapy. the question of the competence of lepromatous patients in resisting certain viral infections arises. | 1983 | 6649746 |
| human papilloma virus infection (condyloma) of the cervix and cervical intraepithelial neoplasia: a histopathologic and statistical analysis. | two hundred fifty consecutive cases previously diagnosed as advanced intraepithelial neoplasia (cin 2 and cin iii) were reviewed and examined for the presence of coexisting condyloma. when the mean ages and age distributions were analyzed, there was a consistent shift of the age distribution to a younger age among women with cin and condyloma as opposed to cin alone. furthermore, when the relationship between age and case accumulation was normalized from a curvilinear to a linear relationship, t ... | 1983 | 6822369 |
| effect of oral aromatic retinoid (ro 10-9359) on human papilloma virus-2-induced common warts. | persisting human papilloma virus (hpv) 2 induced common warts of a chronic lymphatic leukemia patient were orally treated with aromatic retinoid ro 10-9359 (tigason). clinically, the lesions improved rapidly. virus-specific cytopathogenic effects (cpe), virus particles and viral dna were no longer detectable. therapy was discontinued because of the development of a liposarcoma, which led to a complete relapse of the cutaneous lesions. hpv-2 specific parameters, cpe and viral dna, were restored. ... | 1983 | 6840376 |
| [false forms of bowen disease of the genital mucosa]. | this review deals with the lesions of the genitalia histologically mimicking bowen's disease, yet behaving like a benign process. the report is based on data from the literature and on 14 personal cases, four of which are described here as examples. some of the cases, mostly young patients, showed spontaneous regression; in others condylomata acuminata developed on the site of the lesions; in rare instances a "transformation" in lichen planus occurred. for these not really precancerous condition ... | 1983 | 6874339 |
| carcinoma cuniculatum (verrucous carcinoma of the skin): a clinicopathologic study of 46 cases with ultrastructural observations. | forty-six examples of carcinoma cuniculatum, a rare variant of squamous cell carcinoma of the skin, were studied by means of light and electron microscopy and immunoperoxidase techniques. the tumors usually presented as ulcerated, fungating, and polypoid masses with openings of sinus tracts onto the skin surface that exuded foul-smelling greasy material when pressure was applied. on microscopic examination the tumors were seen to be composed mainly of mature squamous keratinocytes with foci of c ... | 1982 | 7042070 |
| histological changes identical to those of condylomatous lesions found in esophageal squamous cell carcinomas. | esophageal specimens derived from sixty patients with an established invasive squamous cell carcinoma of the esophagus were histologically surveyed with special reference to the morphological manifestations of human papilloma virus (hpv), known to cause flat, inverted and papillomatous lesions (condylomas) in the uterine cervix. epithelial changes fulfilling the criteria of the papillomatous condyloma were present in one case, those of the inverted lesions in three cases, and those of the flat c ... | 1982 | 7138240 |
| differential regulation of human papillomavirus type 6 and 11 early promoters in cultured cells derived from laryngeal papillomas. | cells cultured from laryngeal papillomas contain episomal human papillomavirus type 6 or type 11 (hpv-6/11) dna. we developed a sensitive rnase protection assay to simultaneously measure expression from the hpv e6, e7, and e1 promoters (p1, p2 and p3, respectively) in this manipulable culture system and found that p1, p2 and p3 transcript abundances could be independently modulated by culture medium composition and culture substrate. in undifferentiated cells grown in a low-calcium, serum-free m ... | 1995 | 7474101 |
| the viral oncoproteins ad5 e1a, hpv16 e7 and sv40 tag bind a common region of the tbp-associated factor-110. | a function shared by the adenovirus e1a, papillomavirus e7 and sv40 tag oncoproteins is their ability to interfere with normal cell growth by interacting with members of the retinoblastoma protein family. in this study, we show that each of these oncoproteins can also bind to the 921 amino acid tbp-associated factor-110 (taf-110). the significance of the binding is underscored by the observation that each oncoprotein binds to the same 77 amino acid carboxyl region of taf-110. in the case of e1a ... | 1995 | 7478615 |