Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| possible role of the nipah virus v protein in the regulation of the interferon beta induction by interacting with ubx domain-containing protein1. | nipah virus (niv) is a highly pathogenic paramyxovirus that causes lethal encephalitis in humans. we previously reported that the v protein, one of the three accessory proteins encoded by the p gene, is one of the key determinants of the pathogenesis of niv in a hamster infection model. satterfield b.a. et al. have also revealed that v protein is required for the pathogenicity of henipavirus in a ferret infection model. however, the complete functions of niv v have not been clarified. in this st ... | 2018 | 29769705 |
| sixty seconds on . . . nipah virus. | 2018 | 29871862 | |
| enhancing preparation for large nipah outbreaks beyond bangladesh: preventing a tragedy like ebola in west africa. | the nipah virus has been transmitted from person-to-person via close contact in non-urban parts of india (including kerala may 2018), bangladesh, and the philippines. it can cause encephalitis and pneumonia, and has a high case fatality rate. nipah is a one health zoonotic infectious disease linked to fruit bats, and sometimes pigs or horses. we advocate anticipating and preparing for urban and larger rural outbreaks of nipah. immediate enhanced preparations would include standardized guidance o ... | 2018 | 29879523 |
| nipah virus control needs more than r&d. | 2018 | 29900857 | |
| experimental infection of syrian hamsters with aerosolized nipah virus. | nipah virus (niv) is a paramyxovirus (genus henipavirus) that can cause severe respiratory illness and encephalitis in humans. transmission occurs through consumption of niv-contaminated foods, and contact with niv-infected animals or human body fluids. however, it is unclear whether aerosols derived from aforesaid sources or others also contribute to transmission, and current knowledge on niv-induced pathogenicity after small-particle aerosol exposure is still limited. | 2018 | 29912426 |
| development of a novel real-time polymerase chain reaction assay for the quantitative detection of nipah virus replicative viral rna. | nipah virus (niv) is a highly pathogenic zoonotic paramyxovirus that can result in severe pulmonary disease and fatal encephalitis in humans and is responsible for outbreaks in bangladesh, malaysia, singapore, india and possibly the philippines. niv has a negative-sense rna genome that contains six genes and serves as a template for production of viral mrna transcripts. niv mrna transcripts are subsequently translated into viral proteins. traditionally, niv quantitative real-time reverse transcr ... | 2018 | 29920552 |
| circulation of nipah virus in pteropus giganteus bats in northeast region of india, 2015. | 2018 | 29923524 | |
| nipah virus in kerala: a deadly zoonosis. | 2018 | 29935330 | |
| [research progress in enveloped glycoproteins and the membrane-fusion mechanism of nipah virus]. | nipah virus (niv) is the pathogen of an emerging zoonotic disease that is highly lethal and infectious. niv seriously impacts human lives and the property in the epidemic areas and poses a great threat to the global public health security. this paper provides a brief introduction to the morphological structure, and physiological function of the attachment protein g and the fusion protein f, which are both crucial glycoproteins located on the surface of the virus envelope. moreover, recent advanc ... | 2016 | 29963835 |
| sendai virus v protein inhibits the secretion of interleukin-1β by preventing nlrp3 inflammasome assembly. | inflammasomes play a key role in host innate immune responses to viral infection by caspase-1 (casp-1) activation to facilitate interleukin-1β (il-1β) secretion, which contributes to the host antiviral defense. the nlrp3 inflammasome consists of the cytoplasmic sensor molecule nlrp3, adaptor protein asc, and effector protein pro-caspase-1 (pro-casp-1). nlrp3 and asc promote pro-casp-1 cleavage, leading to il-1β maturation and secretion. however, as a countermeasure, viral pathogens have evolved ... | 2018 | 30021903 |
| viral regulation of host cell biology by hijacking of the nucleolar dna-damage response. | recent studies indicate that nucleoli play critical roles in the dna-damage response (ddr) via interaction of ddr machinery including nbs1 with nucleolar treacle protein, a key mediator of ribosomal rna (rrna) transcription and processing. here, using proteomics, confocal and single molecule super-resolution imaging, and infection under biosafety level-4 containment, we show that this nucleolar ddr pathway is targeted by infectious pathogens. we find that the matrix proteins of hendra virus and ... | 2018 | 30076298 |
| a stochastic assembly model for nipah virus revealed by super-resolution microscopy. | understanding virus assembly mechanisms is important for developing therapeutic interventions. nipah virus (niv) is of interest because of its high mortality rate and efficient human-human transmissions. the current model for most enveloped viruses suggests that matrix proteins (m) recruit attachment glycoproteins (g) and fusion glycoproteins (f) to the assembly site at the plasma membrane. here we report an assembly model that differs in many aspects from the current one. examining niv proteins ... | 2018 | 30076303 |
| nipah virus: a new threat to south asia. | 2018 | 30089418 | |
| nipah virus epidemic in southern india and emphasizing "one health" approach to ensure global health security. | nipah virus (niv) encephalitis first reported in "sungai nipah" in malaysia in 1999 has emerged as a global public health threat in the southeast asia region. from 1998 to 2018, more than 630 cases of niv human infections were reported. niv is transmitted by zoonotic (from bats to humans, or from bats to pigs, and then to humans) as well as human-to-human routes. deforestation and urbanization of some areas have contributed to greater overlap between human and bat habitats resulting in niv outbr ... | 2020 | 30090764 |
| world health organization methodology to prioritize emerging infectious diseases in need of research and development. | the world health organization r&d blueprint aims to accelerate the availability of medical technologies during epidemics by focusing on a list of prioritized emerging diseases for which medical countermeasures are insufficient or nonexistent. the prioritization process has 3 components: a delphi process to narrow down a list of potential priority diseases, a multicriteria decision analysis to rank the short list of diseases, and a final delphi round to arrive at a final list of 10 diseases. a gr ... | 2018 | 30124424 |
| position paper on road map for rna virus research in india. | the indian subcontinent with its population density, climatic conditions, means of subsistence, socioeconomic factors as well as travel and tourism presents a fertile ground for thriving of rna viruses. despite being pathogens of huge significance, there is very little focus on research into the biology and pathogenesis of rna viruses in india. studies on epidemiology and disease burden, risk factors, the immune response to rna viruses, circulating virus strains and virus evolution, animal model ... | 2018 | 30131779 |
| changing resource landscapes and spillover of henipaviruses. | old world fruit bats (chiroptera: pteropodidae) provide critical pollination and seed dispersal services to forest ecosystems across africa, asia, and australia. in each of these regions, pteropodids have been identified as natural reservoir hosts for henipaviruses. the genus henipavirus includes hendra virus and nipah virus, which regularly spill over from bats to domestic animals and humans in australia and asia, and a suite of largely uncharacterized african henipaviruses. rapid change in fru ... | 2018 | 30138535 |
| international health threats and global early warning and response mechanisms. | the global community continues to incur the high costs of crisis mitigation and emergency response to outbreaks of emerging infectious diseases, such as those caused by the h5n1 highly pathogenic avian influenza virus, ebola virus, nipah virus, zika virus or the middle east respiratory syndrome coronavirus. these viruses are particularly dangerous in regions associated with poor development indicators and high vulnerability. the drivers of these disease crises include failures in the way that an ... | 2017 | 30152454 |
| what is new in infectious diseases: nipah virus, mers-cov and the blueprint list of the world health organization. | not available. | 2018 | 30246760 |
| emerging trends of nipah virus: a review. | since emergence of the nipah virus (niv) in 1998 from malaysia, the niv virus has reappeared on different occasions causing severe infections in human population associated with high rate of mortality. niv has been placed along with hendra virus in genus henipavirus of family paramyxoviridae. fruit bats (genus pteropus) are known to be natural host and reservoir of niv. during the outbreaks from malaysia and singapore, the roles of pigs as intermediate host were confirmed. the infection transmit ... | 2019 | 30251294 |
| mapping disease transmission risk of nipah virus in south and southeast asia. | since 1998, nipah virus (niv) (genus: henipavirus; family: paramyxoviridae), an often-fatal and highly virulent zoonotic pathogen, has caused sporadic outbreak events. fruit bats from the genus pteropus are the wildlife reservoirs and have a broad distribution throughout south and southeast asia, and east africa. understanding the disease biogeography of niv is critical to comprehending the potential geographic distribution of this dangerous zoonosis. this study implemented the r packages enmeva ... | 2018 | 30274453 |
| phylogeography, transmission, and viral proteins of nipah virus. | nipah virus (niv), a zoonotic paramyxovirus belonging to the genus henipavirus, is classified as a biosafety level-4 pathogen based on its high pathogenicity in humans and the lack of available vaccines or therapeutics. since its initial emergence in 1998 in malaysia, this virus has become a great threat to domestic animals and humans. sporadic outbreaks and person-to-person transmission over the past two decades have resulted in hundreds of human fatalities. epidemiological surveys have shown t ... | 2018 | 30311101 |
| generation of therapeutic antisera for emerging viral infections. | the recent ebola virus outbreak has highlighted the therapeutic potential of antisera and renewed interest in this treatment approach. while human convalescent sera may not be readily available in the early stages of an outbreak, antisera of animal origin can be produced in a short time frame. here, we compared adjuvanted virus-like particles (vlp) with recombinant modified vaccinia virus ankara and vesicular stomatitis virus (vsv), both expressing the ebola virus antigens. the neutralizing anti ... | 2018 | 30323953 |
| the main risk factors of nipah disease and its risk analysis in china. | nipah disease is a highly fatal zoonosis which is caused by the nipah virus. the nipah virus is a bsl-4 virus with fruit bats being its natural host. it is mainly prevalent in southeast asia. the virus was first discovered in 1997 in negeri sembilan, malaysia. currently, it is mainly harmful to pigs and humans with a high mortality rate. this study describes the route of transmission of the nipah virus in different countries and analyzes the possibility of the primary disease being in china and ... | 2018 | 30347642 |
| outbreak investigation of nipah virus disease in kerala, india, 2018. | nipah virus (niv) is a highly fatal emerging zoonotic virus and a potential threat to global health security. here we describe the characteristics of the niv outbreak that occurred in kerala, india, during may-june 2018. | 2019 | 30364984 |
| nipah virus outbreaks: still small but extremely lethal. | 2019 | 30365002 | |
| the interaction between the nipah virus nucleocapsid protein and phosphoprotein regulates virus replication. | continued outbreaks of henipaviruses in south asia and australia cause severe and lethal disease in both humans and animals. together, with evidence of human to human transmission for nipah virus and the lack of preventative or therapeutic measures, its threat to cause a widespread outbreak and its potential for weaponization has increased. in this study we demonstrate how overexpression of the nipah virus nucleocapsid protein regulates viral polymerase activity and viral rna production. by over ... | 2018 | 30375468 |
| evolution of codon usage bias in henipaviruses is governed by natural selection and is host-specific. | hendra virus (hev) and nipah virus (niv) are among a group of emerging bat-borne paramyxoviruses that have crossed their species-barrier several times by infecting several hosts with a high fatality rate in human beings. despite the fatal nature of their infection, a comprehensive study to explore their evolution and adaptation in different hosts is lacking. a study of codon usage patterns in henipaviruses may provide some fruitful insight into their evolutionary processes of synonymous codon us ... | 2018 | 30388838 |
| the killer virus called nipah: a review. | nipah virus (niv) is a deadly virus with a high mortality rate that has affected many developing countries in the past. according to the centers for disease control and prevention (cdc), many economically deprived countries such as madagascar, cambodia, and thailand are also at high risk for future outbreaks. the first case of niv was reported in 1998 and almost two decades later, little scientific progress has been made in finding a proper treatment and prevention vaccine. as many developing co ... | 2018 | 30416895 |
| epitope-based immunoinformatics approach on rna-dependent rna polymerase (rdrp) protein complex of nipah virus (niv). | persistent outbreaks of nipah virus (niv) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease. with little knowledge of its molecular mechanisms, we utilized the proteome data of niv to evaluate the potency of three major proteins (phosphoprotein, polymerase, and nucleocapsid protein) in the rna-dependent rna polymerase complex to count as a possible candidate for epitope-based vaccine design. profound computational analysis was use ... | 2018 | 30417438 |
| epidemics and peptide vaccine response: a brief review. | we briefly review the situations arising out of epidemics that erupt rather suddenly, threatening life and livelihoods of humans. ebola, zika and the nipah virus outbreaks are recent examples where the viral epidemics have led to considerably high degree of fatalities or debilitating consequences. the problems are accentuated by a lack of drugs or vaccines effective against the new and emergent viruses, and the inordinate amount of temporal and financial resources that are required to combat the ... | 2018 | 30417788 |
| computational prediction of mirnas in nipah virus genome reveals possible interaction with human genes involved in encephalitis. | current re-emergence of nipah virus (niv) in india caused 11 deaths so far and many patients were kept in quarantine. a thorough study of previous outbreaks occurred in malaysia, bangladesh and india represents cases with high rate of fatality due to acute encephalitis. our work involves genome analysis of niv for prediction of mirnas and their targeted genes in human in order to understand encephalitis origin. ab-intio program-vmir was used for initial screening of genome, obtained nine pre-mir ... | 2018 | 30426028 |
| tetherin inhibits nipah virus but not ebola virus replication in fruit bat cells. | ebola virus (ebov) and nipah virus (niv) infection of humans can cause fatal disease and constitutes a public health threat. in contrast, ebov and niv infection of fruit bats, the putative (ebov) or proven (niv) natural reservoir, is not associated with disease, and it is currently unknown how these animals control the virus. the human interferon (ifn)-stimulated antiviral effector protein tetherin (cd317, bst-2) blocks release of ebov- and niv-like particles from cells and is counteracted by th ... | 2019 | 30429347 |
| aerosol exposure to intermediate size nipah virus particles induces neurological disease in african green monkeys. | nipah virus (niv) infection can lead to severe respiratory or neurological disease in humans. transmission of niv has been shown to occur through contact with virus contaminated fomites or consumption of contaminated food. previous results using the african green monkey (agm) model of niv infection identified aspects of infection that, while similar to humans, don't fully recapitulate disease. previous studies also demonstrate near uniform lethality that is not consistent with human niv infectio ... | 2018 | 30462637 |
| nipah virus infection of immature dendritic cells increases its transendothelial migration across human brain microvascular endothelial cells. | nipah virus (niv) can infect multiple organs in humans with the central nervous system (cns) being the most severely affected. currently, it is not fully understood how niv spreads throughout the body. niv has been shown to infect certain leukocyte populations and we hypothesized that these infected cells could cross the blood-brain barrier (bbb), facilitating niv entry into the cns. here, three leukocyte types, primary immature dendritic cells (idc), primary monocytes (pmo), and monocytic cell ... | 2018 | 30483242 |
| towards global health security: response to the may 2018 nipah virus outbreak linked to pteropus bats in kerala, india. | 2018 | 30483413 | |
| linkages between chiropteran diversity and ecosystem services for sustainable fragmented forest conservation. | this data article informs about chiropteran diversity, new records, ecosystem services and possible pathogen carriers in fragmented forests (sub-divided by utility corridors, man-made structures, untouched and secondary plantations) within districts setiu (setiu research station), hulu terengganu (saok and lasir waterfalls) and besut (gunung tebu forest reserve) of state terengganu, peninsular malaysia. these bats were captured using harp traps and mist nets that were set 10 m apart across flywa ... | 2018 | 30533456 |
| isolation and full-genome characterization of nipah viruses from bats, bangladesh. | despite molecular and serologic evidence of nipah virus in bats from various locations, attempts to isolate live virus have been largely unsuccessful. we report isolation and full-genome characterization of 10 nipah virus isolates from pteropus medius bats sampled in bangladesh during 2013 and 2014. | 2019 | 30561301 |
| evidence of exposure to henipaviruses in domestic pigs in uganda. | hendra virus (hev) and nipah virus (niv), belonging to the genus henipavirus, are among the most pathogenic of viruses in humans. old world fruit bats (family pteropodidae) are the natural reservoir hosts. molecular and serological studies found evidence of henipavirus infection in fruit bats from several african countries. however, little is known about the potential for spillover into domestic animals in east africa, particularly pigs, which served as amplifying hosts during the first outbreak ... | 2019 | 30576076 |
| persistence of nipah virus rna in semen of survivor. | 2019 | 30590474 | |
| spatial association between a nipah virus outbreak in india and nipah virus infection in pteropus bats. | 2019 | 30590538 | |
| adaptive immune responses in humans during nipah virus acute and convalescent phases of infection. | nipah virus (niv) is 1 of 10 potential causes of imminent public health emergencies of international concern. we investigated the niv outbreak that occurred in may 2018 in kerala, india. here we describe the longitudinal characteristics of cell-mediated and humoral immune responses to niv infection during the acute and convalescent phases in 2 human survivors. | 2019 | 30615097 |
| nipah virus: south india in panic mode. | 2020 | 30647521 | |
| analysis of codon usage patterns and influencing factors in nipah virus. | codon usage bias (cub) is the unequal usage of synonymous codons of an amino acid in which some codons are used more often than others and is widely used in understanding molecular biology, genetics, and functional regulation of gene expression. nipah virus (niv) is an emerging zoonotic paramyxovirus that causes fatal disease in both humans and animals. niv was first identified during an outbreak of a disease in malaysia in 1998 and then occurred periodically since 2001 in india, bangladesh, and ... | 2019 | 30664908 |
| viruses in bats and potential spillover to animals and humans. | in the last two decades, several high impact zoonotic disease outbreaks have been linked to bat-borne viruses. these include sars coronavirus, hendra virus and nipah virus. in addition, it has been suspected that ebolaviruses and mers coronavirus are also linked to bats. it is being increasingly accepted that bats are potential reservoirs of a large number of known and unknown viruses, many of which could spillover into animal and human populations. however, our knowledge into basic bat biology ... | 2019 | 30665189 |
| vaccine development for nipah virus infection in pigs. | nipah virus (niv) causes a severe and often fatal neurological disease in humans. whilst fruit bats are considered the natural reservoir, niv also infects pigs and may cause an unapparent or mild disease. direct pig-to-human transmission was responsible for the first and still most devastating niv outbreaks in malaysia and singapore in 1998-99, with nearly 300 human cases and over 100 fatalities. pigs can therefore play a key role in the epidemiology of niv by acting as an "amplifying" host. the ... | 2019 | 30778392 |
| a conserved basic patch and central kink in the nipah virus phosphoprotein multimerization domain are essential for polymerase function. | nipah virus is a highly lethal zoonotic pathogen found in southeast asia that has caused human encephalitis outbreaks with 40%-70% mortality. niv encodes its own rna-dependent rna polymerase within the large protein, l. efficient polymerase activity requires the phosphoprotein, p, which tethers l to its template, the viral nucleocapsid. p is a multifunctional protein with modular domains. the central p multimerization domain is composed of a long, tetrameric coiled coil. we investigated the impo ... | 2019 | 30799076 |
| nipah virus: a review on epidemiological characteristics and outbreaks to inform public health decision making. | the objectives of this review were to understand the epidemiology and outbreak of niv infection and to discuss the preventive and control measures across different regions. we searched pubmed and scopus for relevant articles from january 1999 to july 2018 and identified 927 articles which were screened for titles, abstracts and full texts by two review authors independently. the screening process resulted in 44 articles which were used to extract relevant information. information on epidemiology ... | 2020 | 30808593 |
| computational identification of inhibitors using qsar approach against nipah virus. | nipah virus (niv) caused several outbreaks in asian countries including the latest one from kerala state of india. there is no drug available against niv till now, despite its urgent requirement. in the current study, we have provided a computational one-stop solution for niv inhibitors. we have developed the first "anti-nipah" web resource, which comprising of a data repository, prediction method, and data visualization module. the database contains of 313 (181 unique) chemicals extracted from ... | 2019 | 30809147 |
| diagnostics for nipah virus: a zoonotic pathogen endemic to southeast asia. | nipah virus (niv) is an emerging pathogen that, unlike other priority pathogens identified by who, is endemic to southeast asia. it is most commonly transmitted through exposure to saliva or excrement from the pteropus fruit bat, or direct contact with intermediate animal hosts, such as pigs. niv infection causes severe febrile encephalitic disease and/or respiratory disease; treatment options are limited to supportive care. a number of in-house diagnostic assays for niv using serological and nu ... | 2019 | 30815286 |
| advances in diagnostics, vaccines and therapeutics for nipah virus. | nipah virus is an emerging zoonotic paramyxovirus that causes severe and often fatal respiratory and neurological disease in humans. the virus was first discovered after an outbreak of encephalitis in pig farmers in malaysia and singapore with subsequent outbreaks in bangladesh or india occurring almost annually. due to the highly pathogenic nature of niv, its pandemic potential, and the lack of licensed vaccines or therapeutics, there is a requirement for research and development into highly se ... | 2020 | 30817995 |
| a spatial assessment of nipah virus transmission in thailand pig farms using multi-criteria decision analysis. | thailand's central plain is identified as a contact zone between pigs and flying foxes, representing a potential zoonotic risk. nipah virus (niv) has been reported in flying foxes in thailand, but it has never been found in pigs or humans. an assessment of the suitability of niv transmission at the spatial and farm level would be useful for disease surveillance and prevention. multi-criteria decision analysis (mcda), a knowledge-driven model, was used to map contact zones between local epizootic ... | 2019 | 30832676 |
| first experience of ribavirin postexposure prophylaxis for nipah virus, tried during the 2018 outbreak in kerala, india. | 2019 | 30851290 | |
| a bimolecular multicellular complementation system for the detection of syncytium formation: a new methodology for the identification of nipah virus entry inhibitors. | fusion of viral and cellular membranes is a key step during the viral life cycle. enveloped viruses trigger this process by means of specialized viral proteins expressed on their surface, the so-called viral fusion proteins. there are multiple assays to analyze the viral entry including those that focus on the cell-cell fusion induced by some viral proteins. these methods often rely on the identification of multinucleated cells (syncytium) as a result of cell membrane fusions. in this manuscript ... | 2019 | 30866435 |
| nipah pseudovirus system enables evaluation of vaccines in vitro and in vivo using non-bsl-4 facilities. | because of its high infectivity in humans and the lack of effective vaccines, nipah virus is classified as a category c agent and handling has to be performed under biosafety level 4 conditions in non-endemic countries, which has hindered the development of vaccines. based on a highly efficient pseudovirus production system using a modified hiv backbone vector, a pseudovirus-based mouse model has been developed for evaluating the efficacy of nipah vaccines in biosafety level 2 facilities. for th ... | 2019 | 30866781 |
| nipah virus infection: a review. | nipah virus (niv) is an emerging bat-borne pathogen. it was first identified 20 years ago in malaysia and has since caused outbreaks in other parts of south and southeast asia. it causes severe neurological and respiratory disease which is highly lethal. it is highly infectious and spreads in the community through infected animals or other infected people. different strains of the virus show differing clinical and epidemiological features. rapid diagnosis and implementation of infection control ... | 2019 | 30869046 |
| nipah virus disease: a rare and intractable disease. | nipah virus, an enveloped ribonucleic acid virus, has been a major cause of encephalitis out-breaks with high mortality, primarily in the indo-bangladesh regions. except for the first outbreak in malaysia-singapore, which was related to contact with pigs and the outbreak in philippines associated with horse slaughter, most other outbreaks have affected the indo- bangladesh regions. the indo-bangladesh outbreaks were associated with consumption of raw date palm sap contaminated by fruit bats and ... | 2019 | 30881850 |
| nano-based approach to combat emerging viral (nipah virus) infection. | emergence of new virus and their heterogeneity are growing at an alarming rate. sudden outburst of nipah virus (niv) has raised serious question about their instant management using conventional medication and diagnostic measures. a coherent strategy with versatility and comprehensive perspective to confront the rising distress could perhaps be effectuated by implementation of nanotechnology. but in concurrent to resourceful and precise execution of nano-based medication, there is an ultimate ne ... | 2019 | 30904587 |
| differential innate immune responses elicited by nipah virus and cedar virus correlate with disparate in vivo pathogenesis in hamsters. | syrian hamsters (mesocricetus auratus) are a pathogenesis model for the nipah virus (niv), and we sought to determine if they are also susceptible to the cedar virus (cedpv). following intranasal inoculation with cedpv, virus replication occurred in the lungs and spleens of infected hamsters, a neutralizing antibody was produced in some hamsters within 8 days post-challenge, and no conspicuous signs of disease occurred. cedpv replicated to a similar magnitude as niv-bangladesh in type i ifn-defi ... | 2019 | 30909389 |
| rapid and specific detection of all known nipah virus strains' sequences with reverse transcription-loop-mediated isothermal amplification. | nipah virus (niv) is a zoonotic virus and can be transmitted through contaminated food or directly between people. niv is classified as a biosafety level 4 agent, not only because of its relatively high case fatality rate, but also because there is no vaccine or other medical countermeasures and it appears to be transmitted by fomites/particulates. the development of rapid detection assay for niv is of great importance because no effective field test is currently available. in this study, an iso ... | 2019 | 30915049 |
| establishment of an immunofluorescence assay to detect igm antibodies to nipah virus using hela cells expressing recombinant nucleoprotein. | a novel indirect fluorescent antibody test (ifat) for detection of igm against nipah virus (niv) was developed using hela 229 cells expressing recombinant niv nucleocapsid protein (niv-n). the niv ifat was evaluated using three panels of sera: a) experimentally produced sera from niv-n-immunized/pre-immunized macaques, b) post-infection human sera associated with a nipah disease outbreak in the philippines in 2014, and c) human sera from a non-exposed malaysian population. immunized macaque sera ... | 2019 | 30954461 |
| using healthcare-seeking behaviour to estimate the number of nipah outbreaks missed by hospital-based surveillance in bangladesh. | understanding the true burden of emergent diseases is critical for assessing public-health impact. however, surveillance often relies on hospital systems that only capture a minority of cases. we use the example of nipah-virus infection in bangladesh, which has a high case-fatality ratio and frequent person-to-person transmission, to demonstrate how healthcare-seeking data can estimate true burden. | 2019 | 30977803 |
| henipaviruses at the interface between bats, livestock and human population in africa. | nipah virus (niv) and hendra virus (hev) are closely related members within the genus henipavirus, family paramyxoviridae, for which fruit bats serve as the reservoir. the initial emergence of niv infections in pigs and humans in malaysia, and hev infections in horses and humans in australia, posed severe impacts on human and animal health, and continues threatening lives of humans and livestock within southeast asia and australia. recently, henipavirus-specific antibodies have also been detecte ... | 2019 | 30985268 |
| henipavirus infection of the central nervous system. | nipah virus (niv) and hendra virus are highly pathogenic zoonotic viruses of the genus henipavirus, family paramyxoviridae. these viruses were first identified as the causative agents of severe respiratory and encephalitic disease in the 1990s across australia and southern asia with mortality rates reaching up to 75%. while outbreaks of nipah and hendra virus infections remain rare and sporadic, there is concern that niv has pandemic potential. despite increased attention, little is understood a ... | 2019 | 30985897 |
| construction of the safe neutralizing assay system using pseudotyped nipah virus and g protein-specific monoclonal antibody. | nipah virus (niv) is a recently emerged paramyxovirus that causes acute respiratory illness and fatal encephalitis in a broad spectrum of vertebrates, including humans. due to its high pathogenicity and mortality rates, niv requires handling in biosafety level-4 (bsl-4) containment facilities and no effective vaccines or therapeutic agents are currently available. since current diagnostic tests for detecting serum neutralizing antibodies against niv mainly employ live viruses, establishment of m ... | 2019 | 30995971 |
| nipah virus sequences from humans and bats during nipah outbreak, kerala, india, 2018. | we retrieved nipah virus (niv) sequences from 4 human and 3 fruit bat (pteropus medius) samples from a 2018 outbreak in kerala, india. phylogenetic analysis demonstrated that niv from humans was 96.15% similar to a bangladesh strain but 99.7%-100% similar to virus from pteropus spp. bats, indicating bats were the source of the outbreak. | 2019 | 31002049 |
| infections among contacts of patients with nipah virus, india. | we conducted a serosurvey of 155 healthcare workers and 124 household and community members who had close contact with 18 patients who had laboratory-confirmed nipah virus infections in kerala, india. we detected 3 subclinical infections; 2 persons had igm and igg and 1 only igm against nipah virus. | 2019 | 31002050 |
| nipah virus: epidemiology, pathology, immunobiology and advances in diagnosis, vaccine designing and control strategies - a comprehensive review. | nipah (nee-pa) viral disease is a zoonotic infection caused by nipah virus (niv), a paramyxovirus belonging to the genus henipavirus of the family paramyxoviridae. it is a biosafety level-4 pathogen, which is transmitted by specific types of fruit bats, mainly pteropus spp. which are natural reservoir host. the disease was reported for the first time from the kampung sungai nipah village of malaysia in 1998. human-to-human transmission also occurs. outbreaks have been reported also from other co ... | 2019 | 31006350 |
| pteropus lylei primarily forages in residential areas in kandal, cambodia. | bats are the second most species-rich mammalian order and provide a wide range of ecologically important and economically significant ecosystem services. nipah virus is a zoonotic emerging infectious disease for which pteropodid bats have been identified as a natural reservoir. in cambodia, nipah virus circulation has been reported in pteropus lylei, but little is known about the spatial distribution of the species and the associated implications for conservation and public health.we deployed gl ... | 2019 | 31015997 |
| rabies-based vaccine induces potent immune responses against nipah virus. | nipah virus (niv) is a re-emerging zoonotic pathogen in the genus henipavirus of the paramyxoviridae family of viruses. niv is endemic to bangladesh and malaysia and is highly fatal to both livestock and humans (human case fatality rate = 74.5%). currently, there is no approved vaccine against niv on the market. the goal of this study was to use a recombinant rabv vector expressing niv glycoprotein (niv g) to develop a bivalent candidate vaccine against niv disease and rabies virus (rabv) diseas ... | 2019 | 31016033 |
| nipah virus induces two inclusion body populations: identification of novel inclusions at the plasma membrane. | formation of cytoplasmic inclusion bodies (ibs) is a hallmark of infections with non-segmented negative-strand rna viruses (order mononegavirales). we show here that nipah virus (niv), a bat-derived highly pathogenic member of the paramyxoviridae family, differs from mononegaviruses of the rhabdo-, filo- and pneumoviridae families by forming two types of ibs with distinct localizations, formation kinetics, and protein compositions. ibs in the perinuclear region form rapidly upon expression of th ... | 2019 | 31034506 |
| transmission of nipah virus - 14 years of investigations in bangladesh. | nipah virus is a highly virulent zoonotic pathogen that can be transmitted between humans. understanding the dynamics of person-to-person transmission is key to designing effective interventions. | 2019 | 31067370 |
| nipah virus (niv): a 'new' addition to the ever changing landscape of infections. | 2018 | 31086681 | |
| erratum: publisher correction: rabies-based vaccine induces potent immune responses against nipah virus. | [this corrects the article doi: 10.1038/s41541-019-0109-5.]. | 2019 | 31098303 |
| use of single-injection recombinant vesicular stomatitis virus vaccine to protect nonhuman primates against lethal nipah virus disease. | nipah virus (niv) is a zoonotic pathogen that causes high case-fatality rates (cfrs) in humans. two niv strains have caused outbreaks: the malaysia strain (nivm), discovered in 1998-1999 in malaysia and singapore (≈40% cfr); and the bangladesh strain (nivb), discovered in bangladesh and india in 2001 (≈80% cfr). recently, nivb in african green monkeys resulted in a more severe and lethal disease than nivm. no niv vaccines or treatments are licensed for human use. we assessed replication-restrict ... | 2019 | 31107231 |
| case fatality rate and risk factors for nipah virus encephalitis: a systematic review and meta-analysis. | a wide range of nipah virus (niv) encephalitis case fatality rates (cfr) have been reported. data on the involvement of several potential risk factors in nipah virus transmission remain controversial. we performed a systematic review and meta-analysis to estimate the pooled cfr of niv encephalitis and to assess the risk factors for niv infection. | 2019 | 31132674 |
| remdesivir (gs-5734) protects african green monkeys from nipah virus challenge. | nipah virus is an emerging pathogen in the paramyxoviridae family. upon transmission of nipah virus from its natural reservoir, pteropus spp. fruit bats, to humans, it causes respiratory and neurological disease with a case-fatality rate about 70%. human-to-human transmission has been observed during nipah virus outbreaks in bangladesh and india. a therapeutic treatment for nipah virus disease is urgently needed. here, we tested the efficacy of remdesivir (gs-5734), a broad-acting antiviral nucl ... | 2019 | 31142680 |
| analysis of nipah virus codon usage and adaptation to hosts. | a recent outbreak of nipah virus (niv) in india has caused 17 deaths in people living in districts of kerala state. its zoonotic nature, as well as high rate of human-to-human transmission, has led researchers worldwide to work toward understanding the different aspects of the niv. we performed a codon usage analysis, based on publicly available nucleotide sequences of niv and its host adaptation, along with other members of the henipavirus genus in ten hosts. niv genome encodes nine open readin ... | 2019 | 31156564 |
| etiology of central nervous system infections in a rural area of nepal using molecular approaches. | the etiology of infections of the central nervous system (cns) in nepal often remains unrecognized because of underdeveloped laboratory facilities. the aim of this study was to investigate the etiology of cns infections in a rural area of nepal using molecular methods. from november 2014 to february 2016, cerebrospinal fluid (csf) was collected from 176 consecutive patients presenting at united mission hospital in tansen, nepal, with symptoms of possible cns infection. after the csf samples were ... | 2019 | 31162021 |
| peripheral immune response in the african green monkey model following nipah-malaysia virus exposure by intermediate-size particle aerosol. | the ability to appropriately mimic human disease is critical for using animal models as a tool for understanding virus pathogenesis. in the case of nipah virus (niv), infection of humans appears to occur either through inhalation, contact with or consumption of infected material. in two of these circumstances, respiratory or sinusoidal exposure represents a likely route of infection. in this study, intermediate-size aerosol particles (~7 μm) of niv-malaysia were used to mimic potential routes of ... | 2019 | 31166946 |
| a single-dose chadox1-vectored vaccine provides complete protection against nipah bangladesh and malaysia in syrian golden hamsters. | nipah virus (niv) is a highly pathogenic re-emerging virus that causes outbreaks in south east asia. currently, no approved and licensed vaccine or antivirals exist. here, we investigated the efficacy of chadox1 nivb, a simian adenovirus-based vaccine encoding niv glycoprotein (g) bangladesh, in syrian hamsters. prime-only as well as prime-boost vaccination resulted in uniform protection against a lethal challenge with niv bangladesh: all animals survived challenge and we were unable to find inf ... | 2019 | 31170144 |
| nipah virus - the rising epidemic: a review. | the nipah virus was discovered twenty years ago, and there is considerable information available regarding the specificities surrounding this virus such as transmission, pathogenesis and genome. belonging to the henipavirus genus, this virus can cause fever, encephalitis and respiratory disorders. the first cases were reported in malaysia and singapore in 1998, when affected individuals presented with severe febrile encephalitis. since then, much has been identified about this virus. these singl ... | 2019 | 31205033 |
| prioritizing surveillance of nipah virus in india. | the 2018 outbreak of nipah virus in kerala, india, highlights the need for global surveillance of henipaviruses in bats, which are the reservoir hosts for this and other viruses. nipah virus, an emerging paramyxovirus in the genus henipavirus, causes severe disease and stuttering chains of transmission in humans and is considered a potential pandemic threat. in may 2018, an outbreak of nipah virus began in kerala, > 1800 km from the sites of previous outbreaks in eastern india in 2001 and 2007. ... | 2019 | 31246966 |
| navigating research toward the re-emerging nipah virus- a new piece to the puzzle. | the recent nipah virus (niv) outbreak in india has caused a state of chaos, with potential to become the next international pandemic. there is still a great deal to learn about niv for the development of a potent treatment against it. the niv non-structural proteins play important roles in the lifecycle of the virus, with the rna-dependent rna-polymerase (rdrp) being a vital component in viral replication. in this study, we not only provide a comprehensive overview of all the literature concerni ... | 2019 | 31258065 |
| nipah virus: a narrative review of viral characteristics and epidemiological determinants. | the objectives of this article are to highlight the properties of the nipah virus (niv) and discuss its epidemiological determinants. | 2019 | 31261032 |
| insights from the fifth international one health congress, 2018, saskatoon, canada. | the recent outbreaks of diseases including ebola reemergence in the democratic republic of congo (drc), nipah virus outbreak in india, lassa virus in nigeria and the continued influenza pandemic show that we cannot predict outbreaks, however, developing response plans could help alleviate the burden of diseases. developing response plans involves strategies such as creating a repository of microbial agents as well as the implementation of the plans. in addition, zoonotic experts and policy maker ... | 2019 | 31303937 |
| containing nipah virus infection. | 2019 | 31310304 | |
| nipah virus infection. | nipah virus infection is an emerging zoonotic infection which presents with acute encephalitis and respiratory distress syndrome. it is associated with high mortality and classified as biosafety level 4 organisms in view of its features which make it a potential agent for bioterrorism. experience with broad spectrum antiviral agent ribavirin is promising in reducing the mortality and morbidity. | 2018 | 31313551 |
| a case series on the recent nipah epidemic in kerala. | during may 2018 there occurred an outbreak in kerala, which started in soopikkada village, changarothu grama panchayath in perambra taluk, kozhikode district, of a febrile illness with altered sensorium and ards. the diagnosis was made from the second case that it is the dreaded nipah infection. following that 18 cases tested positive for nipah virus infection of which 2 survived. also there were four deaths with similar clinical picture but which occurred before the virus was identified. they w ... | 2018 | 31317711 |
| nipah virus persists in the brains of nonhuman primate survivors. | nipah virus (niv) is an emerging zoonotic paramyxovirus that causes highly lethal henipavirus encephalitis in humans. survivors develop various neurologic sequelae, including late-onset and relapsing encephalitis, several months up to several years following initial infection. however, the underlying pathology and disease mechanisms of persistent neurologic complications remain unknown. here, we demonstrate persistent niv infection in the brains of grivets that survived experimental exposure to ... | 2019 | 31341108 |
| recombinant vesicular stomatitis virus vector vaccines for who blueprint priority pathogens. | the devastating ebola virus (ebov) outbreak in west africa in 2013-2016 has flagged the need for the timely development of vaccines for high-threat pathogens. to be better prepared for new epidemics, the who has compiled a list of priority pathogens that are likely to cause future outbreaks and for which r&d efforts are, therefore, paramount (r&d blueprint: https://www.who.int/blueprint/priority-diseases/en/ ). to this end, the detailed characterization of vaccine platforms is needed. the vesicu ... | 2019 | 31368826 |
| establishment of an rna polymerase ii-driven reverse genetics system for nipah virus strains from malaysia and bangladesh. | nipah virus (niv) has emerged as a highly lethal zoonotic paramyxovirus that is capable of causing a febrile encephalitis and/or respiratory disease in humans for which no vaccines or licensed treatments are currently available. there are two genetically and geographically distinct lineages of niv: niv-malaysia (niv-m), the strain that caused the initial outbreak in malaysia, and niv-bangladesh (niv-b), the strain that has been implicated in subsequent outbreaks in india and bangladesh. niv-b ap ... | 2019 | 31371748 |
| dose-response and transmission: the nexus between reservoir hosts, environment and recipient hosts. | dose is the nexus between exposure and all upstream processes that determine pathogen pressure, and is thereby an important element underlying disease dynamics. understanding the relationship between dose and disease is particularly important in the context of spillover, where nonlinearities in the dose-response could determine the likelihood of transmission. there is a need to explore dose-response models for directly transmitted and zoonotic pathogens, and how these interactions integrate with ... | 2019 | 31401955 |
| emergence and adaptive evolution of nipah virus. | since its first emergence in 1998 in malaysia, nipah virus (niv) has become a great threat to domestic animals and humans. sporadic outbreaks associated with human-to-human transmission caused hundreds of human fatalities. here, we collected all available niv sequences and combined phylogenetics, molecular selection, structural biology and receptor analysis to study the emergence and adaptive evolution of niv. niv can be divided into two main lineages including the bangladesh and malaysia lineag ... | 2020 | 31408582 |
| emerging/re-emerging viral diseases & new viruses on the indian horizon. | infectious diseases remain as the major causes of human and animal morbidity and mortality leading to significant healthcare expenditure in india. the country has experienced the outbreaks and epidemics of many infectious diseases. however, enormous successes have been obtained against the control of major epidemic diseases, such as malaria, plague, leprosy and cholera, in the past. the country's vast terrains of extreme geo-climatic differences and uneven population distribution present unique ... | 2019 | 31411169 |
| potential novel inhibitors against emerging zoonotic pathogen nipah virus: a virtual screening and molecular dynamics approach. | nipah virus is a pathogen considered highly infectious, and its lethality can cause between 40% and 70% of deaths in those infected. at present, no effective treatment is available which results in an imperative need to explore new approaches to the search for drugs. through virtual screening techniques, docking and molecular dynamics, 183 ligands were evaluated against the nipah virus glycoprotein (niv-g), involved throughout the process of virus entry to the host cell, resulting in a good targ ... | 2020 | 31411538 |
| absence of nipah virus antibodies in pigs in mizoram state, north east india. | 2019 | 31417037 | |
| strategic development of a next-generation multi-epitope vaccine to prevent nipah virus zoonotic infection. | nipah virus (niv) is an emerging zoonotic pathogen, reported for the recent severe outbreaks of encephalitis and respiratory illness in humans and animals, respectively. many antiviral drugs have been discovered to inhibit this pathogen, but none of them were that much efficient. to overcome the complications associated with this severe pathogenic virus, we have designed a multi-epitope subunit vaccine using computational immunology strategies. identification of structural and nonstructural prot ... | 2019 | 31460434 |
| nipah virus encephalitis: mri findings. | 2019 | 31497792 | |
| optimization and diagnostic evaluation of monoclonal antibody-based blocking elisa formats for detection of neutralizing antibodies to hendra virus in mammalian sera. | maintenance of hendra virus (hev) in pteropid bat populations has been associated with spillover events in horses, humans and dogs. experimental studies have demonstrated infections for several other species including guinea pigs, cats and ferrets. the criteria of a sensitive and specific serological test that is effective for a range of species, but which does not require use of live virus, has not been satisfactorily addressed by currently available tests. we have evaluated the use of two hev ... | 2019 | 31513861 |