Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| evidence that microtubules do not mediate opsin vesicle transport in photoreceptors. | the organization of the rod photoreceptor cytoskeleton suggests that microtubules (mts) and f actin are important in outer segment (os) membrane renewal. we studied the role of the cytoskeleton in this process by first quantifying os membrane assembly in rods from explanted xenopus eyecups with a video assay for disc morphogenesis and then determining if the rate of assembly was reduced after drug disassembly of either mts or f actin. membrane assembly was quantified by continuously labeling new ... | 2009 | 2687292 |
| putidaredoxin competitively inhibits cytochrome b5-cytochrome p-450cam association: a proposed molecular model for a cytochrome p-450cam electron-transfer complex. | cytochrome b5 has been genetically engineered to afford a fluorescent derivative capable of monitoring its association with cytochrome p-450cam from pseudomonas putida [stayton, p. s., fisher, m. t., & sligar, s. g. (1988) j. biol. chem. 263, 13544-13548]. in the mutant cytochrome b5, threonine is replaced by a cysteine at position 65 (t65c) and has been labeled with the environmentally sensitive fluorophore acrylodan. in this paper, the physiological p-450cam reductant putidaredoxin, an fe2s2.c ... | 1989 | 2690937 |
| mechanisms involved in the pathogenesis of yersinia infections. | yersinia enterocolitica and yersinia pseudotuberculosis are food-borne enterobacterial pathogens which may initiate rheumatoid diseases. by molecular genetic analysis of the pathogenicity of these species virulence gene loci could be identified on the chromosome and on a plasmid. plasmid-encoded proteins mediate cell adherence, phagocytosis resistance, survival in serum, cytotoxicity, and collagen binding. y. enterocolitica of serotype 0:8 is mouse-lethal and arthritogenic for lewis rats. mouse ... | 1989 | 2692128 |
| [serum and cerebrospinal fluid kinetics of ceftazidime]. | ceftazidime serum concentrations and cerebrospinal fluid (csf) penetration across non-inflamed meninges were evaluated in 10 patients after intravenous application of 2 g ceftazidime over a period of 30 min. after a continuous increase during infusion the highest level of ceftazidime in serum with 172.27 micrograms/ml (+/- 60.43 micrograms/ml) was ascertained at the end of the infusion. the further development demonstrated a continuous decrease of serum concentrations. concentrations in serum fo ... | 1989 | 2693344 |
| augmentation of the resistance against escherichia coli by oral administration of a hot water extract of chlorella vulgaris in rats. | in previous studies, we demonstrated that a hot water extract of chlorella vulgaris (cve) augmented the resistance against an intraperitoneal infection with escherichia coli by its intraperitoneal, intravenous or subcutaneous administration. the augmented resistance appeared to be attributable to the enhanced activity of polymorphonuclear leukocytes (pmn). in this study, the effect of oral administration of cve against escherichia coli infection was examined. male fisher rats (f344/ducrj) were a ... | 1989 | 2693376 |
| correlated distribution of actin, myosin, and microtubules at the leading edge of migrating swiss 3t3 fibroblasts. | the formation of lamellipodia in migrating cells involves dynamic processes that occur in a cyclic manner as the leading edge of a cell slowly advances. we used video-enhanced contrast microscopy (vec) to monitor the motile behavior of cells to classify protrusions into the temporal stages of initial and established protrusions (fisher et al.: cell motility and the cytoskeleton 11:235-247, 1988), and to monitor the fixation of cells. multiple parameter fluorescence imaging methods (debiasio et a ... | 1989 | 2696599 |
| the need for a search for a proximal pathogenic principle of human aids. | some of the unexplained aspects of hiv/aids epidemiology, virology, and pathology (6, 13) may thus be due to a lack of knowledge of the basic virology of the virus complex and its pathological interaction with cells of the host. there may be no need to call upon anomalous immune responses, vicious transactivating activities, or new virological or biological principles if we can first do the basic virology of the disease-inducing viruses. while we do not want to propose that working out the virol ... | 1989 | 2702660 |
| structural characterization of nitrimyoglobin. | nitrimyoglobin was formed in greater than 94% yield by a simple reaction between excess nitrite and horse heart metmyoglobin at ph 5.5. this dark green pigment was shown by 1h nmr spectroscopy to be a single, pure product with a well defined tertiary structure that is highly similar to the starting myoglobin. electronic spin states parallel those of myoglobin, although the relaxation times differ. ligand binding reactions of nitrimyoglobin parallel those of normal myoglobin, but lead to a unique ... | 1989 | 2703482 |
| new sensitizers for photodynamic therapy: controlled synthesis of purpurins and their effect on normal tissue. | purpurins are a class of porphyrin derivative that have been shown to have good in vivo cytotoxicity to n-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (fanft) induced rat bladder tumors (ay-27) implanted into fisher 344 rats. the synthesis of purpurins from etioporphyrin i and coproporphyrin i proceeds in high yield and with a high degree of regioselectivity. product formation can be rationalized in terms of relief of steric strain about the periphery of the purpurin macrocycle. the effect of ther ... | 1989 | 2704035 |
| [breast saving therapy in the small breast cancer]. | according to the satisfying results reported by fisher, veronesi and other authors who used a breast-conserving operation modality in the treatment of breast cancer since 1980 109 patients with a carcinoma up to 2.5 cm underwent this kind of operation at the surgical department of the hanusch-hospital, vienna. although the median follow-up-time (29 months) is too short for conclusive statements, results of recurrence and survival compared to 162 cases of modified radical mastectomy were satisfyi ... | 1989 | 2704284 |
| [expression of cell surface transformation-associated antigens taas on activated oncogene-transfected rat fibroblast and antitumor immunity by hosts]. | the key point in this study was that the cell surface antigens in the events of transformation were analyzed using the same clonal-derived nontransformed cell and various oncogenes. wka rat fetus-derived fibroblast line, wfb, showed the strict non-transformant phenotypes. transfection of ejras and polyoma middle t oncogenes into wfb resulted in the acquisition of tumorigenicity in vitro and in vivo. the newly expressed cell-surface antigens on some transformants were analyzed using four monoclon ... | 1989 | 2705790 |
| diffusion approximations of the two-locus wright-fisher model. | diffusion approximations are established for the multiallelic, two-locus wright-fisher model for mutation, selection, and random genetic drift in a finite, panmictic, monoecious, diploid population. all four combinations of weak or strong selection and tight or loose linkage are treated, though the proof in the case of strong selection and loose linkage is incomplete. under certain conditions, explicit formulas are obtained for the stationary distributions of the two diffusions with loose linkag ... | 2009 | 2708916 |
| multivariate analysis of a tissue cea, tpa, and ca 19.9 quantitative study in colorectal cancer patients. a preliminary finding. | tissue cea, tpa, and ca 19.9 concentrations from samples of surgical specimens were measured in 47 evaluable colorectal cancer patients (median follow-up, 20 months, 13 recurrences) and correlated with individual patient follow-up status. the quantitative method appeared to be sensitive, easily reproducible, and standardizable. the tissue marker concentration was analyzed by means of the multivariate discriminant analysis, to evaluate the risk of relapse in each patient; the tumor cea (cea t) sh ... | 1989 | 2714130 |
| comparative studies of radiotracer citrates in oncological models--2. 153sm-citrate and 67ga-citrate. | 153sm-citrate solutions were prepared from enriched 152sm2o3 which had been irradiated at 10(12)n cm-2 s-1 in the university of alberta slowpoke reactor. 153sm was rapidly bound (93% in 2 h) by melanoma 2ab cells in tissue culture upon incubation in the presence of 153sm-citrate (1.9 nmol 10(6) cells). in vitro ultracentrifugation studies of 153sm-citrate solutions showed that colloid formation under incubation conditions could have been responsible in part for the uptake by cultured cells. low ... | 1989 | 2714996 |
| age-related alterations in duodenal calcium transport rate in rats. | to determine the age-related alterations in intestinal calcium transport under in vitro controlled conditions, we studied the calcium transport across duodenal segments of prepubertal (2 months), young adult (6 months) and aged (26 months) fisher 344 male rats using the ussing chamber technique. we also evaluated the effect of 10(-11) m 1,25-dihydroxycholecalciferol [1,25-(oh)2d3] in tissue bathing media. the calcium transport rate from mucosa-to-serosa (jms) and from serosa-to-mucosa (jsm) in 2 ... | 1989 | 2716368 |
| fisher syndrome. an infantile case. | a case of acute onset of partial ophthalmoplegia, ataxia and areflexia in a child is described. this case closely resembles those described by fisher (fisher syndrome). clinical data, also in relation to the few cases previously reported, are discussed. | 1989 | 2718813 |
| changes in the hepatic perfusion index during the development of experimental hepatic tumours. | a model of microscopic liver tumour has been developed in the fisher rat by intraportal injection of 1.6 x 10(7) walker 256 carcinosarcoma cells. rats were studied at 2, 4 and 6 days after the inoculation of live walker cells. a control group received dead walker cells. no tumour was visible in control groups at 2, 4 and 6 days after inoculation. similarly in rats injected with live cells no tumour was visible at 2 days after inoculation but at 4 and 6 days the percentage hepatic replacement was ... | 1989 | 2720322 |
| membranous glomerulonephritis and the nephrotic syndrome in a patient with landry-guillain-barré-strohl syndrome. | membranous glomerulonephritis and the nephrotic syndrome concurrent with the miller-fisher variant of the landry-guillain-barré-strohl syndrome (lgbs), acute post-infective polyneuritis, is reported in a 49-year-old man. the onset of heavy proteinuria coincided with the development of the neurological disturbance. while immunosuppressive therapy appeared to hasten improvement in the neurological disease, no such improvement occurred in the glomerulopathy. | 1989 | 2728436 |
| transesophageal atrial pacing: a first-choice technique in atrial flutter therapy. | here we report on a study of 181 episodes of spontaneous atrial flutter (af) (mean atrial cycle length 250 +/- 32 msec) treated by transesophageal atrial pacing (tap) in 138 patients (92 men and 46 women; mean age 59.5 +/- 12.6 years). tap was effective in 163 episodes (90%); sinus rhythm resumption was immediate in 36 (19.9%) and followed a short period of atrial fibrillation in 64 (35.3%); in 63 episodes (34.8%) a stable atrial fibrillation was obtained. tap was unsuccessful in 18 cases (10%). ... | 1989 | 2729054 |
| purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin. | a wide variety of rodent and human tumor cells secrete antigenically related phosphoproteins with molecular weights (mr) of approximately 58,000 (hamster), 62,000 (rat, mouse), 67,000 (human) (senger, d.r. and perruzzi, c.a. (1985) cancer res. 45, 5818-5823). expression of these phosphoproteins is transformation-related; tumor cells produce at least 10-fold or more of this protein as compared to their normal or untransformed counterparts. n-terminal and internal sequences derived from the rat tu ... | 1989 | 2736258 |
| the problem of our common mitochondrial mother. | it has been suggested that the mitochondrial dna (mtdna) of all present-day human beings stems exclusively from one woman who lived about 200000 years ago in africa; examination of the problem by the mathematical theory of random walks supposedly renders alternatives very unlikely. however, a statistical argument first used by fisher indicates that this hypothesis is untenable, at least if the assumptions made by previous workers are accepted. all present-day mtdna might go back to one individua ... | 1989 | 2737664 |
| biodistribution of misonidazole and 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) in rats bearing unclamped and clamped 9l subcutaneous tumors. | the biodistribution of misonidazole (miso) and 1,3bis(2-chloroethyl)-1-nitrosourea (bcnu) was studied using the subcutaneous (s.c.) 9l tumor model in male fisher 344 rats. a transient hypoxia in these tumors was created by clamping the blood supply to the tumor. reoxygenation occurred upon release of the clamp. the plasma and tumor concentrations of miso and bcnu were quantitated by high pressure liquid chromatography. when 12 mg/kg of bcnu was given i.p. without miso, the peak plasma concentrat ... | 1989 | 2745188 |
| morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature. | the purpose of this study was to compare microvascular morphometric and hemodynamic characteristics of a tumor and granulating normal tissue to develop quantitative data that could be used to predict microvascular characteristics which would be most likely associated with hypoxia. the dorsal flap window chamber of the fisher 344 rat was used to visualize the microvasculature of 10 granulating and 12 tumor (r3230 ac adenocarcinoma) tissues at 2 weeks following surgical implantation of the chamber ... | 1989 | 2745213 |
| relapsing polyneuritis following classic miller fisher syndrome. | 1989 | 2746278 | |
| aging: effect on hepatic metabolism and transport of folate in the rat. | effects of aging on hepatic folate metabolism and transport were assessed in male fisher 344 rats. total serum and hepatic folate levels were measured. hepatic folates were measured by high-performance liquid chromatography and by lactobacillus casei assay. transport of 5-methyltetrahydrofolate (5-ch3-h4pteglu) was measured in isolated hepatocytes. serum folate declined with aging; however, neither the total folate level nor the distribution of hepatic folate coenzymes was affected by the aging ... | 1989 | 2756923 |
| treatment of experimental pseudomonas aeruginosa pneumonia with a human igm monoclonal antibody. | a human igm monoclonal antibody (ma-1c1) to fisher immunotype 3 pseudomonas aeruginosa lipopolysaccharide antigen was evaluated for in vivo activity in a guinea pig model of experimental pneumonia. pharmacokinetics of ma-1c1 were compared in infected and noninfected animals. intravenous bolus infusion of ma-1c1, 1 mg/kg, resulted in peak serum antibody concentrations of 3.8 +/- 0.08 and 3.7 +/- 0.05 micrograms/ml in infected and noninfected animals, respectively. serum half-lives were 25 and 22 ... | 1989 | 2760499 |
| changes with aging in the levels of amino acids in rat cns structural elements. ii. taurine and small neutral amino acids. | taurine (tau) and the small neutral amino acids glycine (gly), serine (ser), threonine (thr), and alanine (ala) were measured in 53 brain areas of 3- and 29-month-old male fisher 344 rats. the ratio of highest to lowest level was 34 for tau, 9.1 for thr, 7.6 for gly and ser, and 6.5 for ala. the heterogeneity was found in numerous areas; for example, tau levels were more than 90 nmol/mg protein in 6 areas, and less than 20 nmol/mg protein in 10 areas. similar heterogeneity was found with the oth ... | 1989 | 2761675 |
| expression of a human multidrug resistance gene in ovarian carcinomas. | expression of the human mdr1 gene has been shown to confer the multidrug resistance (mdr) phenotype to sensitive cells. to investigate the possible contribution of the mdr phenotype to chemoresistance in ovarian carcinoma, we have analyzed mdr1 gene expression in fresh carcinoma specimens from 50 patients. fifteen received chemotherapy before surgery and were judged as poor responders. thirty-five patients did not receive any drug before surgery. control tissues were lymphocytes from 7 patients. ... | 1989 | 2766278 |
| chloroform inhibition of 1,2-dimethylhydrazine-induced gastrointestinal tract tumors in the fisher 344 rat. | the effect of chloroform (chcl3), administered at 0, 900, and 1800 mg/liter in the drinking water, on the carcinogenic potency of 1,2-dimethylhydrazine (dmh) was investigated. groups of 40 male fisher 344 rats were given one of the three drinking water solutions for 39 weeks following the subcutaneous injection of 200 mg/kg dmh, a known gastrointestinal (gi) tract carcinogen in this animal strain. when tumors from the gi tract were pooled there was a highly significant (p less than 0.001) decrea ... | 1989 | 2767360 |
| establishment and characterization of an epithelial cell line from the rat submandibular gland. | an epithelial cell line, rsmtx, has been established from the submandibular gland of weanling fisher 344 rats by treatment of explanted tissue clumps with 3-methylcholanthrene. these cells exhibit a polygonal shape on light microscopy and a polar appearance, with desmosomes, terminal bar-like structures, surface microvilli and cytoplasmic interdigitations, when examined by electron microscopy. the cells react positively with an antiserum to cytoskeletal keratin, and a commercial monoclonal antib ... | 1989 | 2769593 |
| correlation of mdr1 gene expression with chemotherapy in neuroblastoma. | forty-one neuroblastoma tumor specimens have been analyzed by northern and slot blot hybridization techniques with human mdr1 gene probes. only one of 15 (6%) tumors from patients who had not received chemotherapy exhibited high levels of mdr1 transcripts, while 11 of 26 (42%) treated tumors showed high levels of mdr1 expression (fisher exact test: p = .03). the results indicate that the level of mdr1 mrna expression is associated with previous chemotherapy, including drugs that select the multi ... | 1989 | 2778826 |
| temporal actions of 16 alpha-hydroxyestrone in the rat: comparisons of lordosis dynamics with other estrogen metabolites and between sexes. | 16 alpha-hydroxyesterone (16ohe1), a metabolite of estradiol (e2) and precursor of estriol (e3), binds to the estrogen receptor (er) with low affinity (3% of e2), but is estrogenic in both in vitro and in vivo systems. this metabolite is able to bind in a non-dissociable manner to the er. we examined these properties in vivo by assessing the temporal dynamics of estrogen metabolite action in the rat brain, using lordosis score (ls) to manual stimulation as a serial bioassay of estrogen effect. m ... | 1989 | 2779234 |
| denial and medical outcome in unstable angina. | denial may be adaptive during hospitalization for acute coronary disease. we studied the impact of denial in 48 patients referred to a tertiary care center for treatment of unstable angina. using the hackett-cassem denial scale, we divided the group into 25 high deniers and 23 low deniers. the two groups were comparable in baseline demographic and social data, coronary risk factors, cardiac history, medical treatment, vital signs, and cardiac catheterization results (number of diseased vessels a ... | 2004 | 2784580 |
| interleukin-1-induced anorexia in the rat. influence of prostaglandins. | the anorexia associated with acute and chronic inflammatory or infectious conditions is poorly understood. our objectives were to explore the anorexigenic effects of interleukin-1 (il-1) in the rat. recombinant human (rh) il-1 beta, murine (rm) il-1 alpha and to a lesser extent rhil-1 alpha significantly reduced food intake at greater than or equal to 4.0 micrograms/kg i.p. but not at lower doses, in young (200-250 g) meal-fed rats on chow diets. the anorexic effect appears to be mediated by pro ... | 1989 | 2786888 |
| effect of magnesium deficiency on interleukin production by fisher rats: effect of interleukins on reduced in vitro lymphocyte responses to concanavalin a and lipopolysaccharide. | the ability of rats fed a magnesium-deficient diet to produce interleukins (ils) and the effect of ils on in vitro lymphocyte mitogenesis have been studied in rats. lack of magnesium resulted in a lower number of plastic-adherent spleen cells and in a reduction of il-1 production. il-2 production was not significantly affected, indicating differential sensitivity of t cells to magnesium deficiency. the diminished mitogenic response of splenocytes to concanavalin a (con-a) was restored by the add ... | 1989 | 2788143 |
| immortalization of rat spleen and thymus t cells by human t-cell leukemia virus type i. | co-cultivation of thymus and spleen cells of fisher and lewis rats with lethally irradiated mt-2 cells harboring human t-cell leukemia virus type i (htlv-i) resulted in the establishment of lymphoid cell lines, firt-1, firs-1, lert-1, and lers-1, respectively. cells of these cell lines had rat t-cell characters as demonstrated by the positive reaction to monoclonal antibodies (mabs) to rat t cell antigens (thy 1 and pan t). they lacked surface immunoglobulins and strongly expressed rat interleuk ... | 1989 | 2788356 |
| the treatment of childhood night terrors through the use of hypnosis--a case study: a brief communication. | night terrors are nocturnal episodes of intense autonomic arousal which are manifested by loud shouting or screaming in terror. the sufferer is not awake and is generally completely amnestic for the episodes. night terrors and other sleep disturbances, such as somnambulism, are disorders of arousal (broughton, 1968; fisher, kahn, edwards, & davis, 1973; guilleminault, 1987). a 10-year-old white male was treated for a 6-year-long bout of night terrors. the hypnotic induction consisted of the fing ... | 1989 | 2793269 |
| effect of trimethoprim/sulphamethoxazole and hyperbaric oxygen on experimental spiroplasma mirum encephalitis. | this study was undertaken to determine the susceptibility of experimentally induced spiroplasma mirum infection in the rat to trimethoprim/sulfamethoxazole (tmp/smx) in combination with hyperbaric oxygen (hbo). one-day-old fisher 344 rats were intracerebrally inoculated with the gt-48 strain of s. mirum and were exposed to regimens employed combined antibiotic and hbo treatments. the exclusive use of tmp/smx produced a significant reduction in mortality (p less than 0.0001) and an absence of cli ... | 1989 | 2799063 |
| [treatment of fractures of the carpal scaphoid with herbert's bone screw. review of 21 clinical cases]. | twenty-one patients with scaphoid fractures treated by internal fixation with the herbert screw are reviewed. nine patients presented acute fractures and twelve had fractures with delayed or non-union. the results of these two kinds of lesions are analyzed following the criteria established by herbert and fisher in 1984. this type of internal fixation gives excellent results in isolated lesions of the scaphoid provided it is correctly executed. | 1989 | 2801079 |
| subfornical organ lesions in rats abolish hyperdipsic effects of isoproterenol and serotonin. | isoproterenol (300 micrograms/ml/kg) and serotonin (2 mg/ml/kg) given sc to rats (n = 27) caused significant drinking (fisher plsd, scheffe f test, dunnett t) in the 1 and 2 hours after injection. such drinking was completely prevented in rats later shown to have complete lesions of their subfornical organs (n = 7). in contrast a response not significantly different from the prelesion response was found in rats later given cortical lesions (n = 11) or other lesions which did not damage the subfo ... | 1989 | 2804709 |
| probability and likelihood in genetic counselling. | the aim of this paper is to clarify some of the concepts used in the calculation of risk in genetic counselling. the use of probability as a measure of risk in a particular case is reviewed, with special reference to the fisher-neyman controversy. the technical concept of likelihood is then introduced and applied to risk probabilities themselves. the difficulties of interpretation are discussed, with a distinction drawn between calculating the risk for a child and inferring the genotype of his m ... | 1989 | 2805378 |
| 1,2-dimethylhydrazine-induced carcinogenesis influenced by different colonic anastomoses in rats. | dispensing subcutaneously 1,2-dimethylhydrazine, intestinal carcinogenesis was investigated in male fisher rats with different surgical colonic anastomoses, producing blind gut loops of isoperistaltic high (fecal stasis) and anisoperistaltic low fecal contact. one hundred and eight rats, except 1 rat of the control group, developed colonic neoplasms. in contrast to the control group, mainly in anastomotic areas and in isoperistaltic blind gut loops with intensive fecal contact huge adenocarcinom ... | 1989 | 2806346 |
| characteristics of submucosal lymphoid tissue located in the proximal colon of the rat. | in this study we have examined the morphology and steroid sensitivity of proximal colonic lymphoid tissue in the fisher 344 rat. a time course study was conducted in which groups of animals were injected subcutaneously with hydrocortisone sodium succinate (125 mg/kg body weight) and killed on days 0-4. thymus, jejunal and ileal peyer's patches and proximal colonic lymphoid tissue were excised, weighed and processed for histological analysis. the results showed that the maximum cytoreductive effe ... | 1989 | 2808123 |
| one-way analysis of variance with unequal variances. | we have designed a statistical test that eliminates the assumption of equal group variances from one-way analysis of variance. this test is preferable to the standard technique of trial-and-error transformation and can be shown to be an extension of the behrens-fisher t test to the case of three or more means. we suggest that this procedure be used in most applications where the one-way analysis of variance has traditionally been applied to biological data. | 1989 | 2813387 |
| an interpretation and proof of the fundamental theorem of natural selection. | fisher's "fundamental theorem of natural selection" has long caused controversy in population genetics theory. viewed as a statement about the increase, or rate of increase, of mean fitness over time, it encounters difficulties with cases arising in a multi-locus system for which mean fitness can decrease. an interpretation of the theorem is put forward here which implies that it is correct as a mathematical statement, but of less biological value than was claimed by fisher. | 1989 | 2814903 |
| [stomatological morbidity analysis in deep-sea fishermen in the gdr]. | 465 male seamen of the gdr's deep-sea fishery (about 10%) had stomatologically been examined at the open sea on board of various cargo-ships. the dmf-t index, the distribution of kinds of fillers, the proportion of primary and secondary caries, the number of teeth being missed, the distribution of eichner classes and the mode and frequency of dentures had been analysed. the quantity and quality of the stomatological care in deep-sea fishers depends on numerous factors of influence, not at least ... | 1989 | 2815159 |
| observations on the lesion site in the miller fisher syndrome: presentation of a case including ct and mri. | debate about the lesion site in the miller fisher syndrome is still going on. we studied a patient with features of the miller fisher syndrome in whom arguments for both central and peripheral nervous system dysfunction were found. | 1989 | 2816280 |
| does sternal fracture increase the risk for aortic rupture? | we retrospectively reviewed the records of 99 patients who suffered sternal fractures between 1968 and 1987. patients ranged in age from 5 to 86 years. the most common cause of injury was a motor vehicle accident. the 99 patients were compared with a concurrent series of 2,106 patients with chest injuries and no sternal fractures. traumatic aortic rupture occurred in 2 of 99 patients with sternal fractures (2%) and in 75 of 2,106 patients without sternal fracture (3.6%). this difference was not ... | 1989 | 2818062 |
| neuropathy in the miller fisher syndrome: clinical and electrophysiologic findings. | the clinical and electrophysiologic findings in 10 patients with miller fisher syndrome (ataxia, ophthalmoplegia, and areflexia) were reviewed. all patients had motor and sensory nerve conduction studies and emg in the arm and the leg, and seven patients had cranial nerve conduction studies. electrodiagnostic abnormalities were found in all patients and were characteristic of an axonal neuropathy or a neuronopathy with predominant sensory nerve changes in the limbs and motor damage in the crania ... | 1987 | 2819783 |
| heat shock-induced changes in the structural stability of proteinaceous karyoskeletal elements in vitro and morphological effects in situ. | karyoskeletal protein fractions prepared from drosophila melanogaster embryos contain morphologically identifiable remnants of nuclear pore complexes and peripheral lamina as well as what appears to be an internal nuclear "matrix" (fisher, p. a., m. berrios, and g. blobel, 1982, j. cell biol., 92: 674-686). structural stability of these proteinaceous assemblies is dependent on thermal incubation in vitro (37 degrees c, 15 min) before subfractionation of nuclei. in the absence of such incubation, ... | 1987 | 2821008 |
| morphometric analysis of the cell outlines of normal and polyomavirus-transformed fr 3t3 fibroblasts. | a method is described for the analysis of cell shape, using an image analyzer connected to a computer to assess the cell outline. a series of parameters to assess the contribution of large cytoplasmic expansions to cell morphology and to cell spreading on a planar substratum were used to quantify the visual morphologic differences between normal (nontransformed; n.3t3) and polyomavirus-transformed (py.3t3) fisher rat 3t3 fibroblasts. the results show that the py.3t3 fibroblasts are more spherica ... | 1987 | 2822058 |
| induction of a novel ca2+-dependent protease in preneoplastic and neoplastic liver tissues during rat liver carcinogenesis. | the activity of a novel ca2+-dependent protease in preneoplastic and neoplastic tissues of male fisher 344 rat liver was examined during experimental liver carcinogenesis. this protease activity is significantly high in hyperplastic nodules and hepatocellular carcinomas which were induced by the method of solt and farber. taken together with our previous report on the promoter-specific induction of this protease, the results suggest the possible importance of this protease in the promotion stage ... | 1987 | 2824086 |
| temperature-sensitive cellular mutant for expression of mrna from murine retrovirus. | the cellular mutant b812 isolated from a fisher rat cell line shows temperature sensitivity of focus formation induced by various retroviruses such as recombinant murine retrovirus containing the middle t gene of polyomavirus (pymlv), kirsten murine sarcoma virus, moloney murine sarcoma virus, and recombinant murine retrovirus containing the src gene of rous sarcoma virus. b812 cells, however, show normal ability to proliferate and synthesize protein at the nonpermissive temperature, suggesting ... | 1988 | 2824838 |
| long-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the peripheral nervous system. clinical and neurophysiological controlled study on subjects with chloracne from the seveso area. | this work was set up to investigate the possible presence of peripheral nervous system involvement as a long-term effect of the exposure to dioxin in 152 subjects with chloracne from the seveso area; 123 age- and sex-matched subjects living in nearby towns with similar environmental pollution formed the control group. the accident in seveso took place in july, 1976, and this study was carried out from october, 1982, to may, 1983. although a peripheral neuropathy was not found in any of the subje ... | 2010 | 2829044 |
| the localization of the lesion in patients with acute ophthalmoplegia, ataxia and areflexia (miller fisher syndrome). a serial multimodal neurophysiological study. | results of comprehensive serial neurophysiological tests from onset to full recovery in 3 patients with the miller fisher syndrome (acute ophthalmoplegia, ataxia and areflexia) are presented. these included emg and nerve conduction, late response (h and f wave) and direct facial motor and blink reflex studies, computerized motor unit number estimation, automated quantitative sensory threshold measurements, quantitative pupillometric and pupillopharmacological studies and multimodality evoked pot ... | 1988 | 2835120 |
| enhancement of the clinical activity of melphalan by the hypoxic cell sensitizer misonidazole. | one hundred patients with non-small cell lung cancer were entered by members of the northern california oncology group into a randomized phase ii trial of i.v. melphalan versus i.v. melphalan with concomitant oral misonidazole. the patients had not received prior chemotherapy. eighty-five patients were evaluable for assessment of response and 89 were evaluable for toxicity analysis. the melphalan/misonidazole group had a superior response rate (two complete and four partial responses among 42 pa ... | 2009 | 2836059 |
| herpes simplex virus-induced dutpase: target site for antiviral chemotherapy. | in studies using mutants of hsv-1 (strain 17), which are defective in inducing the hsv-specific dutpase, fisher and preston concluded that since this enzyme was not essential for hsv replication, it would not be useful as a target site for the development of antiviral agents. in this study, we demonstrate that while these mutants do not induce a hsv-specific dutpase, they do not shut off cellular dutpase activity in infected cells and that the cellular dutpase can function in place of the hsv-in ... | 1988 | 2842952 |
| cytomegalovirus pneumonia after bone marrow transplantation successfully treated with the combination of ganciclovir and high-dose intravenous immune globulin. | to assess the efficacy of the combination of the antiviral agent ganciclovir (9-1,3 dihydroxy-2-propoxymethylguanine) and high-dose intravenous immune globulin for treating cytomegalovirus interstitial pneumonitis after allogeneic bone marrow transplantation. | 1988 | 2847609 |
| relationship between cellular adhesiveness and metastatic activity in polyomavirus-transformed fr3t3 rat cell lines. | a series of polyomavirus-transformed rat cells with varying tumorigenic potential were tested for biophysical parameters possibly related to metastatic properties: adhesive capacity and strength of adhesion to different substrates (laminin, fibronectin and albumin), cell deformability and spreading. two groups of cell lines were defined according to their higher or lower adhesive capacity. adhesivity did not appear to be related to cell deformability and spreading. a weak correlation was suggest ... | 1988 | 2847989 |
| a study of fine specificity of monoclonal antibodies to yeast iso-1-cytochrome c. | seven monoclonal antibodies, prepared to yeast holo- or apo-iso-1-cytochrome c by the method of köhler and milstein (goding, j. w. (1983) monoclonal antibodies: principles and practice, academic press, orlando, fl) were characterized by cross-reaction with a panel of evolutionarily related cytochromes c, apocytochromes c, fragments and homologous and hybrid fragment complexes, inhibition, competitive inhibition, and complementation and fluorescence titration. the results have permitted us to ass ... | 1988 | 2848803 |
| statistical analysis of morphometrically analyzed outlines of cells in culture. comparison of populations of normal and polyomavirus-transformed fr 3t3 fibroblasts. | the correspondence analysis method was used to statistically characterize the morphologies of populations of normal (nontransformed; n.3t3) and polyomavirus-transformed (py.3t3) fisher rat 3t3 fibroblasts in culture, based on morphologic parameters calculated according to a previously described morphometric method. with this statistical method, each cell is considered as a vector in a space defined by an arrangement of the calculated morphologic parameters. the n.3t3 cells and the py.3t3 have tw ... | 1988 | 2849952 |
| precursor prothrombin status in patients receiving anticonvulsant drugs. | protein induced by vitamin k absence (pivka) is the circulating prothrombin precursor found in considerable concentrations when carboxylation of prothrombin is impaired. in this study pivka-positivity was assessed in adult epileptic patients receiving a variety of anticonvulsant drugs. mean pivka (+/- sd) concentration was 4.6 +/- 2.3% in 16 epileptics vs 1.1 +/- 0.7% in 10 age-matched controls (p less than 0.001). 13 of the 16 (81%) epileptics had pivka values above the highest value recorded f ... | 1985 | 2857211 |
| hepatocarcinogenic and promoting action of a choline-devoid diet in the rat. | male fisher 344 rats were solely fed a choline-supplemented diet for 65 to 105 weeks or a choline-devoid diet for 24 to 102 weeks. hepatocellular carcinomas developed in the latter animals, beginning at 24 weeks. other groups of rats were given a single dose of 20 mg diethylnitrosamine/kg, 18 h after a partial hepatectomy and were fed, 4 weeks thereafter, either a choline-supplemented, or a choline-devoid diet for up to 48 weeks. in rats fed the choline-supplemented diet, the only relevant lesio ... | 1985 | 2859112 |
| the capability for regulation of insulin secretion by somatostatin in purified pancreatic islet b cells during aging. | pancreatic islet b cells from sprague-dawley and fisher 344 rats aged 3-27 months were separated from a and d cells by centrifugation over a linear percoll density gradient, and incubated in vitro with various concentrations of glucose and somatostatin. elevation of glucose concentration in the incubation medium from 2.6 to 16.7 mm provokes an insulin secretory response that is independent of rat donor age. inhibition of the insulin secretory response by somatostatin is independent of rat donor ... | 1986 | 2870220 |
| serum ferritin values in nigerian pregnant women. | serum ferritin values have been studied in 28 indigenous nigerian pregnant women during the second and third trimesters of pregnancy. the mean serum ferritin value in the second trimester is higher than that in the third trimester, however, the difference is not statistically significant. when our results are related to those of fenton and co-workers in 1977 (fenton v, cavill i, fisher j: iron stores in pregnancy. br j haem 37: 145, 1977) it appears that serum ferritin decreases in early pregnan ... | 2010 | 2874081 |
| the effects of reserpine and haloperidol on tyrosine hydroxylase activity in the brains of aged rats. | many neurotransmitter systems appear to be altered with aging. the effects of aging on the regulation of tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of catecholamines in the brain has been examined. the endogenous basal activity of tyrosine hydroxylase was lower in the hypothalamus of 24 month old fisher 344 rats than in the hypothalamus of 3 month old or 6 month old animals. there was no difference in the basal activity of tyrosine hydroxylase in the locus ceruleus, frontal ... | 1986 | 2874461 |
| the dynamics of phase partition. a study of parameters affecting rat liver organelle partitioning in aqueous two-polymer phase systems. | separation of subcellular organelles by two-phase partition is thought to reflect differential partition of the organelles between the two phases or between one of the phases and the interface. studies by fisher and colleagues [fisher & walter (1984) biochim. biophys. acta 801, 106-110] suggest that cell separation by phase partition is a dynamic process in which the partition changes with time. this is mainly due to association of the cells with sedimenting droplets of one phase in the bulk of ... | 1986 | 2874790 |
| [neuromediator binding to receptors in the rat brain. the effect of chronic administration of ginkgo biloba extract]. | the present data confirm the results of others that post-synaptic receptor changes may contribute to the decline in brain cholinergic function in ageing and dementia. we have also shown that chronic oral treatment with an extract of gingko biloba increases the apparent muscarinic receptor population in the hippocampus of the aged fisher 344 rat. the possible effect on (3h) kainic acid binding to the kainate-excitatory amino acid site is also interesting because of the proposed association of neu ... | 1986 | 2878427 |
| enzyme histochemistry of the rat nasal mucosa embedded in cold glycol methacrylate. | the nasal passages are anatomically complex, and while there have been a number of descriptions of nasal structure in many species, there is very little information available on the distribution of enzymes in the nasal mucosa. in rodents, this delicate mucosa is the first site within the respiratory tract to be exposed during inhalation toxicology studies designed to assess human risks from such exposures. however, the nasal mucosa presents problems for histologic preparation because it is encas ... | 1987 | 2887103 |
| immunosuppression by succinylacetone. ii. prevention of graft-vs-host disease. | succinylacetone is a seven-carbon organic ketoacid that we have previously shown to inhibit tumor allograft rejection as well as the primary antibody response to sheep erythrocytes in rats. because it appeared to be such a potent immunosuppressive agent in our initial studies, we evaluated succinylacetone for its ability to block graft-vs-host disease (gvhd) in adult f1 rats injected with parental strain spleen cells. untreated ace x lewis f1 rats given lewis strain spleen cells died of gvhd, wi ... | 1987 | 2889780 |
| lithium increases dynorphin a(1-8) and prodynorphin mrna levels in the basal ganglia of rats. | the aim of this study was to understand the possible influence of the antimanic drug, lithium, and the neuroleptic, haloperidol, alone or in combination, on the regulation of dynorphin biosynthesis in the striatum. the study was done using male fisher-344 rats subjected to a regimen of subchronic administration of lithium chloride (4 meq/kg/day for 1,2,4 or 6 days, i.p.) or a regimen of chronic oral administration of a diet containing lithium carbonate (1.5 g/kg of the diet). subchronic administ ... | 1988 | 2898269 |
| clinical utility of thyrotropin-receptor antibody assays: comparison of radioreceptor and bioassay methods. | thyrotropin (thyroid-stimulating hormone or tsh)-receptor antibodies, important in the pathogenesis of graves' disease, can be assayed by one of two methods: (1) bioassays that measure stimulation of thyroid cellular activity by patient immunoglobulins or (2) radioreceptor assays that measure inhibition of binding of labeled tsh to tsh receptors by the same substances. in this study, we report our experience with bioassay of thyroid-stimulating immunoglobulins (tsi) based on measurement of gener ... | 1988 | 2898572 |
| dual secretory and myoepithelial differentiation in the transplantable r3230ac rat mammary carcinoma. | the hormone-responsive r3230ac mammary carcinoma, serially transplantable in fisher rats, shows striking functional and morphological similarities to the normal mammary gland. we have studied its cellular composition by both light and electron microscopy, employing markers of myoepithelial and epithelial cells. we identified two cell types: the major cellular component corresponded to epithelial milk-protein secreting cells, while a second component showed immunocytochemical and ultrastructural ... | 1988 | 2898832 |
| activation of mhc-restricted rat t cells by cloned syngeneic thyrocytes. | we have previously demonstrated that rat thyrocytes express mhc class ii ag (rt1.b&d) in response to ifn-gamma. to determine whether mhc class ii-positive thyrocytes can be recognized by mhc-restricted t cells, we used our clone of rat thyroid cells (1b-6) derived from the fisher rat thyroid cell line (frtl-5) and known to express mhc class ii ag in response to recombinant rat ifn-gamma. cd4+ and cd8+ normal syngeneic fisher rat spleen t cells were selected by flow cytometry and averaged greater ... | 1988 | 2899600 |
| balsalazide in the maintenance treatment of patients with ulcerative colitis, a double-blind comparison with sulphasalazine. | balsalazide (bsz) is a pro-drug which releases 5-aminosalicylic acid (5asa) and 4-aminobenzoyl-beta-alanine (an inert carrier) in the colon of various species including man. bsz was compared with sulphasalazine (sasp) (both 1 g b.d. orally) in the maintenance of remission in patients with ulcerative colitis (uc). seventy-nine patients (53 male, 26 female), mean age 49 years (range 19-79 years), with uc were randomly allocated to either treatment (41 bsz, 38 sasp) for 6 months. the groups were si ... | 1988 | 2908755 |
| retinal light damage reduces autofluorescent pigment deposition in the retinal pigment epithelium. | lipofuscin in the retinal pigment epithelium (rpe) is thought to be derived from phagocytosed photoreceptor outer segment disc membranes. based on this hypothesis, one would predict that the rate of lipofuscin deposition in the rpe would be proportional to the density of photoreceptor cells in the retina. in previous studies it was demonstrated that specific loss of photoreceptor cells due to a genetic defect resulted in a substantial decrease in the rate of age-related lipofuscin accumulation i ... | 1989 | 2912913 |
| calculation of transmitral flow by doppler echocardiography: a comparison of methods in a canine model. | although several doppler echocardiographic methods for measuring transmitral flow have been described, the optimal method for calculation of flow remains unclear. seven time/shape combinations were tested in an experimental preparation in which mitral flow could be precisely controlled and measured. annular shape was considered to be either circular or elliptical, and the mitral orifice area was calculated from the anteroposterior and/or the mediolateral dimension(s) recorded at early and middia ... | 1989 | 2916413 |
| response of rat alveolar macrophages to ozone: quantitative assessment of population size, morphology, and proliferation following acute exposure. | the purpose of this study was to evaluate the in vivo effects of an acute exposure to low levels of ozone on rat pulmonary alveolar macrophages (pam). fisher 344 rats exposed to 0.0, 0.12, 0.8, or 1.5 ppm o3 for 6 h were killed immediately after and 3, 18, 42, or 66 h after ozone exposure and their lungs were lavaged. compared to sham-exposed (control) rats, exposure to 0.12 ppm o3 had no measurable effect on the total number, labeling index (li), mitotic index (mi), or morphology of rat alveola ... | 1989 | 2917543 |
| evaluation of prognostic factors in cerebral arteriovenous malformations. | in a retrospective study of 48 patients who underwent elective surgery for cerebral arteriovenous malformations, a statistical analysis of demographic, clinical, and neuroradiological data was undertaken in order to discover the best predictors of operative morbidity. in addition, the predictive value of different clinical grading systems as applied to this series was compared. all patients had a computed tomographic scan and a positive angiogram before surgery. complete resection was proven ang ... | 2010 | 2918970 |
| low inspired gas temperature and respiratory complications in very low birth weight infants. | we analyzed 3705 measurements of inspired gas temperature in the first 96 hours of life, with concurrent measurements of ventilator variables and arterial oxygen tension, to determine any relationship to respiratory sequelae in 149 infants assisted by artificial ventilation. all management was with one type of ventilator (model iv100b, sechrist industries inc., anaheim, calif.) and one type of humidifier (model mr 500, fisher and paykel, auckland, new zealand), and infants were placed under radi ... | 1989 | 2921688 |
| fiber number and type composition in extensor digitorum longus, soleus, and diaphragm muscles with aging in fisher 344 rats. | histochemical (m-atpase) fiber typing was done on extensor digitorum longus, (edl), soleus (sol), and diaphragm (dia) muscles of barrier-reared fisher 344 rats obtained at four different ages (3, 9, 28, and 30 months) from the colonies of the national institute of aging. in the edl there are no differences in the percent of type i fibers among the four age groups. the percent of type iia and iib fibers also showed no difference between the 3 and 30 month age groups. there was no apparent trend f ... | 1985 | 2931475 |
| dopaminergic modulation of the diethylstilbestrol-induced proliferation of the anterior pituitary gland of the fisher 344 rat. | bromocriptine (cb 154), a potent agonist upon the d-2 receptor, blocks the proliferation of the mammotrophs and the elevation of serum prolactin concentration induced by chronic exposure of male fisher 344 rats to diethylstilbestrol (des). fluphenazine, a dopamine receptor antagonist, blocks these effects of cb 154. we conclude that a d-2 receptor occurs on the proliferating mammotroph of the male fisher 344 rat and that stimulation of this receptor inhibits prolactin release and stops the des-i ... | 1985 | 2932654 |
| a myosin heavy-chain-like polypeptide is associated with the nuclear envelope in higher eukaryotic cells. | a high molecular weight polypeptide, identified as an atpase subunit by direct ultraviolet photoaffinity labeling, has been shown to be a component of nuclear envelope-enriched fractions prepared from a variety of higher eukaryotes (berrios, m., g. blobel, and p. a. fisher, 1983, j. biol. chem., 258:4548-4555). in rat liver as well as drosophila melanogaster embryos, this polypeptide appears to be a form of myosin heavy chain. this conclusion is based on both immunochemical and immunocytochemica ... | 1986 | 2943745 |
| polysaccharide surface antigens expressed by nonmucoid isolates of pseudomonas aeruginosa from cystic fibrosis patients. | we tested nonmucoid pseudomonas aeruginosa isolates obtained from cystic fibrosis (cf) patients for the expression of lipopolysaccharide (lps) serotype antigens, serum sensitivity, and production of mucoid exopolysaccharide (mep). when all nonmucoid isolates were compared with a set of random mucoid isolates, 20 of 52 (38%) nonmucoid isolates were typable and serum resistant, compared with 13 of 51 (24%) mucoid isolates (p = 0.16 by chi-square analysis). however, nonmucoid strains from cf patien ... | 1986 | 2943759 |
| mechanical and histochemical characterization of skeletal muscles from senescent rats. | maximal shortening velocity (vmax) and isometric tension (po) were measured in living fiber bundles and skinned fibers from extensor digitorum longus (edl) and soleus (sol) muscles of young adult (9 mo) and senescent (30 mo) fisher 344 rats. the fiber type composition of each muscle preparation was determined using myosin (m)-atpase histochemistry. vmax, determined by the slack test method, was unchanged in the edl but was increased in the sol muscles of young adult vs. senescent rats. velocitie ... | 1986 | 2944390 |
| chronic inflammatory polyradiculoneuropathy with ophthalmoplegia. | we report a case of chronic progressive inflammatory polyradiculoneuropathy with a subacute exacerbation that included ataxia, tendon areflexia, ptosis, and ophthalmoplegia. spinal fluid protein was elevated and electrophysiological studies revealed a demyelinating neuropathy. this case suggests a continuum between chronic inflammatory polyradiculoneuropathy and the miller fisher variant of acute inflammatory polyneuropathy. | 1986 | 2946724 |
| magnetic resonance imaging and the "one-and-a-half" syndrome: a case report. | a patient is described who had magnetic resonance imaging (mri) findings of a left paramedian pontine ischemic stroke. it was associated with right motor sensory and left cerebellar dysfunction and the "one-and-a-half" syndrome of fisher. | 1987 | 2958509 |
| induction by e1a oncogene expression of cellular susceptibility to lysis by tnf. | tumour necrosis factor alpha (ref. 1), synthesized primarily by monocytes in response to various invasive agents, induces a wide variety of biological effects relevant to regulating cell growth and differentiation, including the selective killing of some tumour cells and the growth stimulation of some normal fibroblasts. as tumour necrosis factor (tnf) appears to kill tumour cells preferentially, we asked whether tnf sensitivity correlates with the expression of specific oncogene(s). if so, by e ... | 2006 | 2960901 |
| lambda cro repressor complex with or3 dna: 15n nmr observations. | 15n nmr studies of the coliphage lambda cro repressor are presented. the protein has been uniformally labeled with 15n, and individual amino acids have been incorporated. although the four c-terminal residues (63-66) were not located in the original crystallographic studies of the protein [anderson, w.f., ohlendorf, d.h., takeda, y., & matthews, b.w. (1981) nature (london) 290, 754], it has been proposed that the c-terminus is involved in dna binding [ohlendorf, d.h., anderson, w.f., fisher, r.g ... | 1987 | 2962634 |
| paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult rats. | adult male fisher rats injected with streptozotocin (stz) to produce diabetes mellitus demonstrated a significant loss of total body weight associated with adipose and muscle tissue wasting. paradoxically, intestinal mass and length were increased in stz-treated rats despite catabolism of other tissues. concomitant with increased intestinal mass, food and water intake increased significantly in stz-diabetic animals. renal weight was not reduced despite the fall in total body weight. it is propos ... | 1988 | 2967640 |
| understanding the central processing limit in consistent-mapping visual search tasks. | effects of load (i.e., the number of stimuli in the display) have been observed in multiple-frame studies using a consistent mapping of stimuli to responses (e.g., fisher, 1982, 1984). in a series of four experiments, it is shown that these effects are not the consequence of differences across the high- and low-load conditions in either decision noise or peripheral masking. additionally, it is shown that of two modes of limited capacity (a limited-channel and divided-capacity model) considered a ... | 1988 | 2967879 |
| renal phosphate transport in humoral hypercalcemia of malignancy. | fisher rats bearing the h-500 leydig cell tumor (lct) develop humoral hypercalcemia of malignancy (hhm), which is accompanied by hypophosphatemia and hyperphosphaturia. to better define the mechanisms underlying the changes in phosphate metabolism, the activity of sodium-dependent phosphate uptake (na+-pi) in microvillus membrane vesicles (mmv) isolated from the renal cortex of lct-bearing rats was studied. ten days after tumor transplantation the animals became hypercalcemic, hypophosphatemic, ... | 1988 | 2974244 |
| fisher information in the logistic model. | 1987 | 2977701 | |
| testicular lh receptors during aging in fisher 344 rats. | levels of serum lh, prolactin, testosterone, progesterone and 17-oh progesterone and the testicular concentration and total content of lh receptors were measured in 4-, 11-, 18-, and 27-month-old fisher 344 rats. all 27-month-old rats had leydig cell tumors. at first, testicular lh receptor levels decreased with age, but with the appearance of the testicular tumors, these levels increased dramatically. serum prolactin levels fluctuated with age, but were significantly decreased in 27-month-old r ... | 1985 | 2982778 |
| relapsing ophthalmoparesis-sensory neuropathy syndrome. | we studied two patients with recurrent sensory neuropathy and weakness of extraocular muscles. there was electrophysiologic evidence of multifocal demyelination of sensory nerves, with relative sparing of somatic motor nerves. sural nerve biopsy in one patient showed segmental demyelination. we believe that these patients had an unusual form of inflammatory polyneuropathy--possibly a relapsing variant of the miller-fisher syndrome of acute idiopathic polyneuritis. | 1985 | 2984602 |
| stability and utility of the unique human small cell carcinoma line shp-77. | the human small cell (oat cell) carcinoma line, shp-77, established by fisher and paulson in 1977 and originally described as a "large cell variant of oat cell cancer" has been evaluated by several different parameters and shown even after more than 200 passages to retain properties described for the original cell line. karyotypic, histological, and biochemical features are retained, as well as tumorigenicity in nude mice. the original authors' suggestion that this is a propitious cell line for ... | 1985 | 2985251 |
| correction of abnormal renal blood flow response to angiotensin ii by converting enzyme inhibition in essential hypertensives. | in 40-50% of patients with essential hypertension, a high sodium intake does not increase renal blood flow (rbf). these patients have been defined as nonmodulators because sodium intake does not modulate renal and adrenal responsiveness to angiotensin ii (aii). to define the role of aii in mediating this altered responsiveness, we assessed the effect of a converting enzyme inhibitor (enalapril) on rbf and its responsiveness to aii in 25 patients with essential hypertension--10 modulators and 15 ... | 1985 | 2985655 |
| the simian virus 40 sequences between 0.169 and 0.423 map units are not essential to immortalize early-passage rat embryo cells. | f8dl is a simian virus 40 early-region deletion mutant that lacks the sequences between 0.169 and 0.423 map units. we show that cloned f8dl dna immortalized early-passage fisher rat embryo cells with an efficiency that was about 20% of that of cloned wild-type simian virus 40 dna. in contrast, we detected no immortalized colonies when we transfected the cells with dna of five other early-region deletion mutants that do not make stable truncated forms of t antigen. since all five of these mutants ... | 1985 | 2987680 |
| rhinovirus inactivation by nasal tissues treated with virucide. | rhinovirus colds may be transmitted by hand-to-hand contact followed by self-inoculation of nasal and/or conjunctival mucosa with virus contaminating the fingertips. the purpose of this study was to determine whether impregnation of nasal tissues with virucidal compounds could prevent rhinovirus from passing through the tissue and thus provide a means of preventing hand contamination during nose blowing. paper tissues treated with a combination of citric acid, malic acid, and sodium laruryl sulf ... | 2006 | 2990332 |
| hepatic neoplastic nodules, adenofibrosis, and cholangiocarcinomas in male fisher 344 rats fed corn naturally contaminated with fusarium moniliforme. | twelve male fisher 344 rats were fed corn naturally contaminated with fusarium moniliforme. this corn sample was obtained from feed being fed horses during an outbreak of leukoencephalomalacia. all rats necropsied from 123 to 176 days post feeding had multiple hepatic nodules and pale depressed hepatic areas. histological examination revealed multiple hepatic neoplastic nodules and large areas of adenofibrosis and cholangiocarcinomas. the corn only diet was deficient in many nutrients including ... | 1985 | 2990756 |