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prevention of carcinogenesis by murine sarcoma virus (harvey) following injections of immune sera during the latent period. 19694310638
biological activity and separation of a leukaemogenic virus from murine sarcoma virus-harvey (msv-h). 19694310639
murine sarcoma virus: titration patterns and interference by a murine leukemia virus. 19694310643
[factors antagonistic to interferon extracts from tumors induced by murine sarcoma virus in hamsters]. 19694310956
murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells.a continuous cell line of highly contact-inhibited cells (nih/3t3) has been developed from nih swiss mouse embryo cultures. its growth properties are similar to those of 3t3 and balb/3t3. although 3t3 is relatively insensitive to focus formation by murine sarcoma viruses, cloned lines of both nih/3t3 and balb/3t3 have been isolated that are highly sensitive to sarcoma virus focus formation and leukemia virus growth. the sensitivity and specificity are comparable to those found with primary embry ...19694311790
alterations in the characteristics of sugar uptake by mouse cells transformed by murine sarcoma viruses. 19694312003
transformation and virus growth by murine sarcoma viruses in human cells. 19704312364
studies of hamster-specific oncogenic virus derived from hamster tumors induced by kirsten murine sarcoma virus. 19704313154
trans-species rescue of defective genomes of murine sarcoma virus from hamster tumor cells with helper feline leukemia virus.this report describes a trans-species rescue of defective msv genome with helper leukemia virus derived from cats. this rescue was achieved by in vitro co-cultivation of hamster tumor cells with feline embryo cells in the presence of helper feline leukemia virus (felv), or by inoculation of tumor cells into felv-infected newborn cats. the rescued focus-forming viruses produced foci in feline embryo cultures but not in cultures of mouse, rat, and hamster species. one isolate was tested and found ...19704313195
dependence of murine sarcoma virus infection on the cell cycle. 19704313400
evidence for a functional change in the plasma membrane of murine sarcoma virus-infected mouse embryo cells. transport and transport-associated phosphorylation of 14c-2-deoxy-d-glucose. 19704313605
control of multiplication of uninfected rat cells and rat cells converted by murine sarcoma virus. 19704313839
studies on murine sarcoma virus; a morphological comparison of tumorigenesis by the harvey and moloney strains in mice, and the establishment of tumor cell lines. 19694314173
production of virus by mammalian cells tranformed by rous sarcoma and murine sarcoma viruses.cultured cells of mammalian tumors induced by ribonucleic acid (rna)-containing oncogenic viruses were examined for production of virus. the cell lines were established from tumors induced in rats and hamsters with either rous sarcoma virus (schmidt-ruppin or bryan strains) or murine sarcoma virus (moloney strain). when culture fluids from each of the cell lines were examined for transforming activity or production of progeny virus, none of the cell lines was found to be infectious. however, ele ...19684316021
replication of defective and competent forms of murine sarcoma virus in mouse cell cultures. 19704316311
the behaviour of two strains of murine sarcoma virus in vitro. 19704316690
altered glucose transport kinetics in murine sarcoma virus-transformed balb-3t3 clones. 19704317728
carcinogenesis by rna sarcoma viruses. xiv. infection of stationary cultures with murine sarcoma virus (harvey). 19704318031
focus formation by a murine sarcoma leukemia virus complex. ii. quantitative aspects of the interaction between radiation leukemia virus and its murine sarcoma virus pseudotype in strain c57bl mouse embryo cells.a quantitative study has been made of the interactions between radiation leukemia virus (radlv), its murine sarcoma virus pseudotype, and their c57bl host cells. the elimination of interference phenomena by delayed infection of cells with radlv made possible the quantitative determination of the pseudotype in terms of defective sarcoma and endogenous radlv particles. this in turn permitted the quantitative assessment of radlv helper activity and of the various factors which influence the accurac ...19704318086
use of a murine sarcoma virus in an in vivo assay for antiviral and antitumor agents. 19704318464
mechanism of carcinogenesis by rna tumor viruses. i. an rna-dependent dna polymerase in murine sarcoma viruses.a highly active and stable dna polymerase was found in purified preparations of two murine sarcoma viruses. enzyme activity is not detected in most virus preparations unless they are treated with low concentrations of a nonionic detergent such as nonidet p-40. the incorporation of labeled thymidine triphosphate requires all four deoxyribonucleoside triphosphates and either mg(2+) or mn(2+). enzyme activity is proportional to virus concentration and is linear with time up to 90 min. that the temp ...19704318786
nonproducer clones of murine sarcoma virus transformed balb-3t3 cells. 19704318987
[transplantable osteosarcoma caused by the "moloney strain of murine sarcoma virus (m-msv)" in osborne-mendel rats]. 19704319060
isolation of murine sarcoma virus-transformed mouse cells which are negative for leukemia virus from agar suspension cultures. 19704319233
control of multiplication of uninfected mouse embryo fibroblasts and mouse embryo fibroblasts converted by infection with murine sarcoma virus (harvey). 19704319758
murine sarcoma virus transformation of balb-3t3 cells: lack of dependence on murine leukemia virus.murine sarcoma virus induces foci of morphologically altered cells in balb/3t3 cultures. focus formation in mouse cells has been thought to require the presence of a helper, murine leukemia virus, which is present in murine sarcoma virus stocks but by itself does not induce any morphological transformation of mouse cells. the present studies show that early after infection, the titration pattern for murine sarcoma virus in balb/3t3 cells is "two-hit" since only foci produced by virus spread can ...19704319884
enhancement of murine sarcoma virus (moloney) infection in mice by guaroa virus. 19704321083
immunity to murine sarcoma virus (msv)-induced tumors demonstrated by "in vivo" elimination of 51-chromium labeled tumor cells. 19704322224
glycopeptides from the surface of control and virus-transformed cells.glycopeptides were removed by trypsin digestion from the surface of control cells and cells transformed by rous sarcoma virus, murine sarcoma virus, or polyoma virus. after digestion with pronase, the glycopeptides were analyzed by gel filtration. the elution profiles suggest that there are differences in the glycopeptides from the surface of control cells and those from transformed cells.19714323250
retention of antigen specificity of murine sarcoma viruses grown in hamster cells in vitro. 19714324572
in vivo enhancement of a murine sarcoma virus by diethylaminoethyl-dextran. 19714325778
cellular interactions in vitro with cells derived from tumors induced by murine sarcoma virus (harvey). 19714325932
transformation of mouse 3t3 cells by murine sarcoma virus: release of virus-like particles in the absence of replicating murine leukemia helper virus.small numbers of virus-like particles were observed by electron microscopy in each of two cloned lines of 3t3 cells transformed by murine sarcoma virus, even though these lines were free of detectable quantities of infectious leukemia and sarcoma virus. the morphology and occurrence of the particles were identical to those of the murine leukemia-sarcoma group. moreover, the particles incorporated uridine and had a buoyant density of 1.16 g/ml in sucrose gradients. no evidence of sarcoma or leuke ...19714327005
nucleic acid and proteins isolated from a strain of murine sarcoma virus (msv-o). 19714327113
the effects of oronasal administration of two strains of murine sarcoma virus in mice. 19714330220
lack of requirement of murine leukemia virus for early steps in infection of mouse embryo cells by murine sarcoma virus. 19714331113
cytoplasmic dna synthesis induced by rna tumor viruses.infection of mouse embryo cells with two strains of murine sarcoma virus and one strain of murine leukemia virus was followed rapidly by synthesis of dna in the cytoplasm. persistently infected cells have not shown such synthesis, and ultraviolet-irradiated virus did not induce dna synthesis. this new dna presumably represents an intermediate in the virus replication cycle specified by the virion dna polymerase(s). failure to observe cytoplasmic dna synthesis in persistently infected cells sugge ...19714331562
the kinetics of rescue of the murine sarcoma virus genome from a nonproducer line of transformed mouse cells. 19714331729
chemical induction of focus-forming virus from nonproducer cells transformed by murine sarcoma virus.focus-forming virus can be induced by chemicals from virus-negative clonal lines of cells transformed by murine sarcoma virus. the viruses activated from such nonproducer cells have the host range and serologic properties of endogenous helper viruses of the cells rather than those of the sarcoma virus used to transform them. the evidence indicates that murine sarcoma virus-transformed nonproducer cells of two species contain the genetic information for both murine sarcoma and helper virus produc ...19714332005
rescue of murine sarcoma virus from a sarcoma-positive leukemia-negative cell line: requirement for replicating leukemia virus.the nature of murine sarcoma virus (msv) "defectiveness" was investigated by employing an msv-transformed mouse 3t3 cell line which releases noninfectious virus-like particles. rescue kinetics of msv, observed after murine leukemia virus (mulv) superinfection of these "sarcoma-positive leukemia-negative (s + l -)" mouse 3t3 cells, consisted of a 9- to 12-hr eclipse period followed by simultaneous release of both msv and mulv with no evidence for release of infectious msv prior to the production ...19714332138
cell line derived from a murine sarcoma virus (moloney pseudotype)-induced tumor: cultural, antigenic, and virological properties.a cell line derived from a murine sarcoma virus (moloney pseudotype)-induced tumor has been established. it retains oncogenicity, releases both sarcoma and leukemia viruses, and has virus-induced cellular antigens.19714332935
clonal isolation of murine sarcoma virus (msv): characterization of virus produced from transformed cells. 19714332977
immunobiological studies of tumors induced by murine sarcoma virus (kirsten). 19724333497
detection of some murine leukemia virus antigens in virus particles derived from 3t3 cells transformed only by murine sarcoma virus. 19724333569
characterization of murine sarcoma virus (kirsten) transformation of mouse and human cells. 19714333712
demonstration of differences in murine sarcoma virus foci formed in mouse and rat cells under a soft agar overlay. 19714333721
immune complex diseases. i. pathological changes in the kidneys of balb-c mice neonatally infected with moloney leukaemogenic and murine sarcoma viruses. 19714333814
the murine sarcoma virus (msv). 19714333859
expression of a new complement-fixing antigen reactive with murine sarcoma virus rat antiserum in rat cells transformed by polyoma virus. 19724334196
stimulation of dna synthesis and enhancement of murine sarcoma virus replication in mouse embryo cells by sv 40. 19724334773
ultraviolet inactivation of moloney leukaemia virus: relative target size required for virus replication and rescue of 'defective' murine sarcoma virus. 19724334784
age dependent resistance to polyoma and murine sarcoma viruses in mice. 19724334879
increased uptake of amino acids and 2-deoxy-d-glucose by virus-transformed cells in culture.transformed and nontransformed cells in tissue culture differ in their rate of uptake of certain nutrients, as determined by a polyester-coverslip technique. a 2.5- to 3.5-fold increased rate of uptake of alpha-aminoisobutyric acid, cycloleucine, and 2-deoxy-d-glucose was observed with polyoma virus-transformed baby hamster kidney (bhk) 21 cells and simian virus 40 (sv40)-transformed balb/3t3 (mouse fibroblast) cells, compared to their nontransformed counterparts. kinetic analysis suggested that ...19724335068
properties of a murine sarcoma virus isolated from a tumor arising in an nzw-nzb f 1 hybrid mouse. i. isolation and pathology of tumors induced in rodents. 19724335642
properties of a murine sarcoma virus isolated from a tumor arising in an nzw-nzb f 1 hybrid mouse. ii. physical and biological characteristics. 19724335643
deficiency of viral ribonucleic acid-dependent deoxyribonucleic acid polymerase in noninfectious virus-like particles released from murine sarcoma virus-transformed hamster cells.virions from hamster cells transformed by a new strain of murine sarcoma virus (msv) appear to represent a form of msv deficient in one or more of the viral components necessary for infectivity. both the noninfectious virions and the sarcoma virus-transformed cells, which have no detectable replicating leukemia helper virus of either murine or hamster origin, are deficient in viral-type ribonucleic acid (rna)-dependent deoxyribonucleic acid (dna) polymerase activity (i.e., reverse transcriptase ...19724335663
replication of radiation-induced murine leukemia virus in normal and transformed mouse cells.autonomous radiation-induced leukemia virus (radlv) replication could be detected in mouse 3t3 cells by the development of interference with murine sarcoma virus (msv), the appearance of covert helper activity for defective msv, and by the induction of cytopathic effect type foci in msv-transformed, leukemia virus-negative (s+l-) cells. a chronic infection of either 3t3 or s+l- cells with radlv could be established. both radlv infectivity and helper activity were demonstrated in the same peak at ...19724335664
co-infection of mouse spleen cells with murine sarcoma virus and guaroa virus.enhancement of tumor induction by oncornaviruses through a dual viral infection has been described by several investigators. the mechanism(s) of this enhancement has not as yet been determined. by using a murine sarcoma virus and a bunyawera group arbovirus (guaroa virus) in an in vitro system, evidence was obtained for enhancement of the oncogenic potential of the viruses by genetic interaction with the nononcogenic virus as well as the production of increased amounts of the oncogenic virus. th ...19724336016
[loss of cellular sensitivity to endogenous interferon induced with the murine sarcoma virus]. 19724336176
comparison of murine sarcoma viruses in nonproducer and s + l - -transformed cells.the biologic properties of murine sarcoma viruses in nonproducer and s(+)l(-) cells were compared. each virus was found to be genetically stable through at least two cycles of rescue and transmission to new cells. there was no evidence for production of a defective murine leukemia virus by s(+)l(-) cells. the results are most consistent with the hypothesis that the sarcoma genome in s(+)l(-) cells contains information for replication functions which the virus in nonproducer cells either lacks or ...19724336564
amantadine hydrochloride: inhibitory effect on murine sarcoma virus infection in cell cultures. 19724336828
the genome of rna tumor viruses contains polyadenylic acid sequences.the 70s genome of two rna tumor viruses, murine sarcoma virus and avian myeloblastosis virus, binds to millipore filters in buffer with high salt concentration and to glass fiber filters containing poly(u). these observations suggest that 70s rna contains adenylic acid-rich sequences. when digested by pancreatic rnase, 70s rna of murine sarcoma virus yielded poly(a) sequences that contain 91% adenylic acid. these poly(a) sequences sedimented as a relatively homogenous peak in sucrose gradients w ...19724337237
stress and murine sarcoma virus (moloney)-induced tumors. 19724337829
transformation of guinea pig embryo cells by a murine sarcoma virus. 19724337992
reversion of murine sarcoma virus transformed mouse cells: variants without a rescuable sarcoma virus.murine sarcoma virus transformed mouse 3t3 cells, which are negative for murine leukemia virus and which yield sarcoma virus after superinfection with murine leukenmia virus, spotaneously give rise to flat variants front which murine sarcoma virus can no longer be rescued. the revertants support leukemia viruis growth and show an enhanced sensitivity to murine sarcoma superinfection and, like normal cells, do not release rna-dependent dna polymerase activity. because revertants could be obtained ...19724338196
viral rna subunits in cells transformed by rna tumor viruses.single-stranded 35s and 20s viral rna species are synthesized in virus-producing mouse and rat cells transformed by the murine sarcoma virus. a transformed hamster cell line that does not produce virus synthesizes 35s, but not 20s viral rna.19724338254
3-cyclic amine derivatives of rifamycin: strong inhibitors of the dna polymerase activity of rna tumor viruses.derivatives of rifamycin-sv with substituted cyclic-amine side chains in position 3 of the ansa ring are strong inhibitors of rna-directed dna and dna-directed dna polymerase activity of rna tumor viruses of murine, feline, and avian origin. among 37 3-amine derivatives of rifamycin-sv that were tested, 29 3-cyclic amine derivatives were good inhibitors of the viral polymerases. especially active were 3-piperidyl derivatives of rifamycin-sv with cyclohexyl and cyclohexylalkyl substituents. deriv ...19724338589
gazdar strain of murine sarcoma virus. biologic and antigenic interactions with the heterologous hamster host. 19724339068
tumors and other lesions induced by murine sarcoma viruses. 19724339212
rescue of the genome of the defective murine sarcoma virus from a non-producer hamster tumor cell line, pm-1, with murine and feline leukemia viruses as helpers. 19724339414
correlation between murine sarcoma virus buoyant density, infectivity, and viral rna electrophoretic mobility. 19724342084
transformation of a rat epithelial-like cell line by murine sarcoma virus. 19724342614
retransformation of ts sv40 transformants by murine sarcoma virus at non-permissive temperature. 19724343945
effects of dibutyryl cyclic adenosine phosphate plus theophylline on murine sarcoma virus transformed non-producer cells. 19724345701
an anemia-inducing virus derived from tumors caused by murine sarcoma virus--moloney. 19724345969
replication of the moloney murine sarcoma-leukemia virus in xc cells.the xc rat cell line was found to support the replication of a strain of the moloney murine sarcoma-leukemia virus. in growth curve experiments cytopathology was paralleled by the production of murine sarcoma virus and leukemia virus progeny having the biologic, antigenic, and biophysical properties of the infecting virus.19734346280
immunologic and virologic studies of a nonproducer tumor induced by murine sarcoma virus (harvey). 19724347035
transformation of rat liver cells with chicken sarcoma virus b77 and murine sarcoma virus.rat liver cells in vitro were transformed with chicken sarcoma virus b77, giving rl(b77) cells, and with murine sarcoma virus (harvey), giving rl(msv) cells. rat liver cells transformed spontaneously in vitro were designated rl cells. in addition, the rl(msv) cell line was adapted for growth in culture fluid containing 25 mug of 5-bromodeoxyuridine per ml. all cell lines were tumorigenic in 1-wk-old rats. the number of cells needed for induction of tumor growth was 1,000-fold higher in the case ...19734347422
characterization of morphologic revertants of murine and avian sarcoma virus-transformed cells.morphologic revertants which contain avian or murine sarcoma viruses have previously been isolated at low frequency from clonal lines of transformed mammalian cells. in the present study, these lines have been further characterized. they are indistinguishable from nontransformed parent cell lines with respect to parameters such as saturation density and colony formation in depleted medium or on monolayers of contact-inhibited cells. the rate of glucose uptake had also reverted to normal. the mal ...19734347425
evidence for naturally occurring murine sarcoma virus. 19734349720
production and characterization of human cell-adapted murine rauscher virus pseudotype of murine sarcoma virus. 19734349764
mouse strain-related differences in the biologic and immunologic responses to a murine sarcoma virus. 19734350031
control of group-specific antigen synthesis by the defective gazdar murine sarcoma virus genome. 19734350230
appearance of virus-specific rna, virus particles, and cell surface changes in cells rapidly transformed by the murine sarcoma virus. 19734350416
isolation of human amnion cells transformed by rescuable murine sarcoma virus. 19734350532
myogenic cells derived from murine sarcoma virus induced mouse tumours: dna synthesis and the effects of simian virus 40 infection. 19734350888
lack of sequence homology between the 70s rna of various rna tumor viruses and the dna of simian virus 40 or polyoma virus.no significant hybridization was detected of dna from simian virus 40 or polyoma virus, and of 70s rna from avian myeloblastosis virus, murine leukemia virus (rauscher), murine sarcoma virus (kirsten), rd-114b, simian sarcoma virus-1, or mason-pfizer virus.19734351455
demonstration of a cell-surface antigen associated with murine sarcoma virus by immunoelectron microscopy.cells transformed by murine sarcoma virus have been examined for the presence of a new virus-associated cell-surface antigen by immunoelectron microscopy. a common antigen has been detected on the surface of nonproductively transformed cells that were induced by two different strains of murine sarcoma virus, kirsten and moloney. this antigen shows crossreaction with cell lines transformed by murine sarcoma virus that were produced in two different mammalian species, rats and mice. further, this ...19734351802
infection of embryonic myogenic cells with murine sarcoma virus in vitro. 19734352205
continuous propagation of radiation leukemia virus on a c57bl mouse-embryo fibroblast line, with attenuation of leukemogenic activity.the radiation leukemia virus (radlv), a murine leukemia virus derived from thymic lymphomas induced by x-irradiation in strain c57bl/ka mice, has been successfully propagated in sustained high titer in vitro in a newly established line, bl-5, of c57bl/ka mouse-embryo fibroblasts. in addition, the production of endogenous virus, presumed to be radlv, has been induced and sustained through multiple serial passages after treatment of bl-5 cell cultures with 5-bromodeoxyuridine. the chronically radl ...19734352226
mutants of nonproducer cell lines transformed by murine sarcoma viruses. i. induction, isolation, particle production, and tumorigenicity.a variety of cell mutants were obtained by a single 5'-bromodeoxyuridine (brdu) treatment of an nonproducer (np) cell line transformed by the kirsten strain of murine sarcoma virus (ki-msv). isolation procedures of these cell see pdf for structure mutants are described. the cell mutants obtained were classified by tumorigenic potential and shedding of type c virus particles. the cell mutants were classified into four groups: (a) tumorigenic, without particles; (b) tumorigenic, with type c partic ...19734352583
properties of mouse embryo cells infected with murine sarcoma virus and simian virus 40 simultaneously in vitro. 19734353215
variants of simian virus 40-transformed 3t3 cells that are resistant to concanavalin a.by treating populations of simian virus 40 (sv40)-transformed 3t3 cells with concanavalin a, variants have been isolated which are resistant to the killing action of the lectin. the variants (i) resemble 3t3 cells morphologically and in some of their growth characteristics; (ii) are not agglutinated by high concentrations of concanavalin a or wheat germ agglutinin, but can be rendered agglutinable by treatment with low concentrations of trypsin; (iii) bind the same number of concanavalin a molec ...19734353502
nonproducer clones of murine sarcoma virus transformed guinea pig embryo cells. 19734353525
evidence for helper independent murine sarcoma virus. i. segregation of replication-defective and transformation-defective viruses. 19734355528
differential response of rat tooth germs to a murine sarcoma virus in cell culture and syngeneic transplants. 19734355602
inhibitory effect of streptonigrin on a murine sarcoma virus-induced tumor cell line (msc) and selection of drug-resistant clones. 19734355799
a scanning electron microscope study of surface features of viral and spontaneous transformants of mouse balb-3t3 cells.cells of the mouse line balb/3t3 as well as three virus-induced transformants and two spontaneous transformants grown in vitro have been studied for their topography by scanning electron microscopy. the parent cell in confluent culture closely resembles an endothelial cell in its form and in the structure of its association with adjacent cells. the tumorigenic transformants produced by sv40, murine sarcoma virus, or polyoma viruses are fusiform to pleomorphic and distinctly different from the ce ...19734357459
low-molecular-weight rnas of murine sarcoma virus: comparative studies of free and 70s rna-associated components.several low-molecular-weight rnas were released from mouse leukemia sarcoma virus 70s rna under conditions of thermal denaturation. one of them, the 70s-associated 8s rna, exhibits a number of structural properties characteristic of a previously described free viral 8s rna. this similarity was revealed by polyacrylamide gel electrophoresis and nucleotide composition.19734357522
in vivo and in vitro studies on the morphogenesis of tumors induced by murine sarcoma virus (harvey). 19734357761
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