Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [effect of the site of microbial aerosol application on the pathogenesis and clinical picture of aerosol infection]. | on the basis of experimental and clinical study of infections with the aerosol mechanism of infection there was revealed a relationship between the fractional-dispersive composition of the microbial aerosol, the porta of infection and the clinico-pathogenetic peculiarities of the course of the disease. on the example of tularemia, plague and other nosological forms it was demonstrated that coarse-dispersive aerosol caused development of oculo-bubonic and anginous-bubonic form of the disease, whe ... | 1976 | 185856 |
| equine herpesviruses: type 3 as an abortigenic agent. | the inoculation of equine herpesvirus type 3 (ehv3) strain 65/61 into the amniotic cavity of a mare 6-7 months pregnant resulted in abortion 11 days later. following abortion typical lesions of coital exanthema were not observed in the genital tract of the mare, nor was ehv3 isolated from her. serological evidence, however, indicated that the mare was infected with ehv3 following inoculation. grossly the foetal disease was characterised by placentitis, focal ulcerative dermatitis, focal necrosis ... | 1976 | 186003 |
| iso-cytochrome c species from baker's yeast. analysis of their circular-dichroism spectra. | the circular-dichroism spectra of baker's-yeast iso-1- (methylated and unmethylated forms) and iso-2-cytochrome c species were examined between 200 and 600nm. in the visible region the yeast haemoproteins have characteristics nearly indistinguishable from those of horse heart cytochrome c. from the spectra in the u.v. region the latter appears, however, to be more helical. it is proposed that the likely element of non-helical structure in iso-1-cytochrome c is residues 62-70. | 1976 | 186031 |
| studies on oxidative phosphorylation and steroidogenesis by ovarian mitochondria after gonadotropic stimulation. | no differences in oxidative phosphorylation or in the per cent of [4-14c]progesterone were found in ovarian mitochondria of immature rats after treatment with 20 iu of pregnant mare serum gonadotropin (pmsg) iv 30 min before killing. however, treatment of immature rats with 20 iu of pmsg sc 54 h prior to killing decreased the adp:o ratio and increased the per cent of [4-14c]cholesterol conversion. electron microscopic studies showed that mitochondria with lamellar cristae were prominent in ovari ... | 1976 | 186255 |
| kinetic transients in the reduction of aldehydes catalysed by liver alcohol dehydrogenase. | the transient-state kinetics of enzymic reduction of acetaldehyde and benzaldehyde by nadh, catalyzed by horse liver alcohol dehydrogenase, have been examined under single-turnover conditions, obtained by carrying out reactions either with limiting amounts of enzyme in the presence of 20 mm pyrazole or with limiting amounts of substrate. analysis of the variation with substrate, coenzyme, and enzyme concentrations of amplitudes and time constants for the exponential transients observed at 328 nm ... | 1976 | 186264 |
| pathogenesis of visna. ii. effect of immunosuppression upon early central nervous system lesions. | it was hypothesized that the lesions of visna might represent an immunopathologic process. to test this hypothesis, a 1-month schedule of immunosuppressive treatment was devised, using horse anti-sheep thymocyte serum. in hampshire sheep, this regime was shown to protect against experimental allergic encephalomyelitis, to inhibit development of tuberculin hypersensitivity, to retard rejection of skin homografts by 3 weeks, and to markedly reduce the number and mitogenic responsiveness of periphe ... | 1976 | 186661 |
| [isolation of a reovirus from a horse with respiratory disease]. | 1976 | 186988 | |
| the purification and kinetic properties of biophosphoglycerate synthase from horse red blood cells. | 1976 | 187124 | |
| copper and the oxidation of hemoglobin: a comparison of horse and human hemoglobins. | oxidation studies of hemoglobin by cu(ii) indicate that for horse hemoglobin, up to a cu(ii)/heme molar ratio of 0.5, all of the cu(ii) added is used to rapidly oxidize the heme. on the other hand, most of the cu(ii) added to human hemoglobin at low cu(ii)/heme molar ratios is unable to oxidize the heme. only at cu(ii)/heme molar ratios greater than 0.5 does the amount of oxidation per added cu(ii) approach that of horse hemoglobin. at the same time, binding studies indicate that human hemoglobi ... | 1976 | 187214 |
| influenza: its antigenic variation and ecology. | influenza viruses have two surface antigens, the glycoprotein structures hemagglutinin (ha) and neuraminidase (na). antibodies to each of these are associated with immunity, but the structures themselves are antigenically variable. when an antigenic change is gradual over time it is referred to as a drift, while a sudden complete or major change in either or both antigens is termed a shift. the mechanism of antigenic drift is usually attributed to selection of preexisting mutants by pressure fro ... | 1976 | 187273 |
| effects of follicle stimulating hormone and luteinizing hormone upon cyclic amp and cyclic gmp levels in rat ovaries in vitro. | in vitro effects of fsh and lh on adenosine 3',5'-cyclic monophosphate (cyclic amp) and guanosine 3',5'-cyclic monophosphate (cyclic gmp) levels in rat ovarian tissue were studied. ovaries from immature rats treated with either pregnant mare's serum (pms) or pms and human chorionic gonadotropin (hcg) were incubated at 37 c for 30 min in defined medium 199 containing aminophylline (0.1 mg/ml). increasing concentrations of lh (0.4-10.0 mug) when added to the medium containing ovaries with predomin ... | 1976 | 187411 |
| pregnant mare serum gonadotrophin: ratio of follicle-stimulating hormone and luteinizing hormone activities measured by radioreceptor assay. | specific radioreceptor assays for fsh and lh, which employ tissue receptors from rat testis and highly purified human fsh (ler 1575-c) and lh (hartree irc-2, 24/6/69) as standards, have been developed to determine the fsh-like and lh-like activities in pregnant mare serum gonadotropin (pmsg). measurements of fsh and lh concentrations in the serum of six pregnant pony mares showed that the ratio of these two activities did not vary significantly between mares and remained constant between days 40 ... | 1976 | 187709 |
| [influenza a/equine 2: example for an atypical course in a group of 21 horses]. | 1976 | 188127 | |
| estrogen use in postmenopausal women. | fifteen per cent of postmenopausal women living in a retirement community used oral estrogens. both use and new-use continued in the seventh, eighth and ninth decades of life, although use and age-specific use-prevalence declined after age 70. mean duration of most recent continuous use was 105 months. vaginal estrogenic preparations were used infrequently, briefly, and usually by women who also used oral estrogens in the same year. the most commonly used oral estrogenic preparation was conjugat ... | 1977 | 188333 |
| clinical pharmacology of antibacterial drugs in the uterus of the mare. | 1977 | 188793 | |
| eia research. | 1977 | 189175 | |
| effects of pressure on visible spectra of complexes of myoglobin, hemoglobin, cytochrome c, and horse radish peroxidase. | the spectra of the ferric form of most heme proteins [metmyoglobin, methemoglobin, horse radish peroxidase (ec 1.11.1.7), and ferricytochrome c at ph 1.5] are converted from high-spin (open crevice) structure to low-spin (closed crevice) form under pressure. pressures up to 8000 kg/cm2 (780 mpa) have no effect on the spectra of high-spin ferro- and ferricytochrome c, which have a closed crevice structure at ph 7.0. spectra of deoxy-ferromyoglobin and deoxy-ferrohemoglobin are reduced in intensit ... | 1977 | 189301 |
| in vitro cytotoxicity of serum and peripheral blood leukocytes for equine herpesvirus type 1-infected target cells. | the immune response in horses following experimental infection with equine herpesvirus type 1 (ehv-1) was assessed by measuring cytotoxicity for ehv-1-infected target cells. a technique was developed, using [125i]5-iodo-2'-deoxyuridine ([125i]iudr)-labeled equine fetal kidney cells infected with ehv-1 as the target cells. it was shown that peripheral blood leukocytes from a recovered horse were capable of lysing target cells, as measured by the loss of radio-active label. following the experimen ... | 1977 | 189645 |
| [nephroblastoma on a horse-shoe kidney]. | a female child, 5 years 10/12 old, is presented with a nephroblastoma inserted on a horse-shoe kidney. she is in a satisfactory state 14 months after surgery. the authors emphasize the favorable outcome with a treatment of combined surgery, radiotherapy and vincristine. | 1976 | 189653 |
| isolation of an adenovirus from an arab foal with a combined immunode ficiency disease. | some details of the clinical and postmortem findings of an arab foal that died as a consequence of adenoviral pneumonia superimposed on a combined immunodeficiency disease are provided. the foal was the 17th in a series of similar deaths that occurred on a farm since 1959. an adenovirus, which by haemagglutination inhibition and serum neutralisation tests was antigenically similar to 2 other equine adenoviruses isolated in australia, was isolated from a nasal swab taken from the foal when it was ... | 1976 | 189745 |
| solvent denaturation of globular proteins: unfolding by the monoalkyl- and dialkyl-substituted formamides and ureas. | the effects of the monoalkyl and dialkyl-substituted formamide series of denaturants on the native conformation of sperm whale myoglobin, horse heart cytochrome c, and glycera dibranciata (single chain) hemoglobin have been investigated by spectral measurements in the soret region (409 and 422 nm) and optical rotation measurements (265nm). the effectiveness of these two classes of protein denaturants is similar to the other straight-chain compounds of the urea, amide, and alcohol classes, examin ... | 1977 | 189823 |
| control of bovine adrenal cortical cell proliferation by fibroblast growth factor. lack of effect of epidermal growth factor. | primary functional bovine adrenal cortical cell cultures have been developed to study the factors controlling adrenal cell growth. cells were prepared by the collagenase technique and maintained in f-12 medium containing fetal calf serum and horse serum. cells contained abundant lipid as demonstrated by staining with oil red o and showed strongly positive staining for delta5,3beta-hydroxysteroid dehydrogenase. acth inhibited dna synthesis and stimulated steriodogenesis in these cells. fibroblast ... | 1977 | 189990 |
| transmission of the cytochrome c structural gene in horse-donkey crosses. | donkey cytochrome c was shown to differ from horse cytochrome c by having a serine in position 47 rather than a threonine. the rest of the amino acid sequences are identical. mules and hinnies, both males and females, carry equal amounts of horse and donkey cytochromes c. the same ratio is found in hinnies in preparations from heart tissue and from skeletal muscle. these results demonstrate that cytochrome c is transmitted in horse-donkey crosses as a simple mendelian character which is neither ... | 1977 | 190219 |
| formation of a biologically active, ordered complex from two overlapping fragments of cytochrome c. | a noncovalent complex of the apoprotein (1-104) and cyanogen bromide heme fragment containing residues 1 to 65, (1-65) h, has been prepared from horse heart cytochrome c. conditions under which the redundant portions of the ferrous complex can be removed by limited trypsin digestion have been devised. the complementing fragments have been isolated from the derived complexes and four apofragments and one heme fragment have been identified in the amino acid sequence of cytochrome c. they are (39-1 ... | 1977 | 190231 |
| failure to demonstrate equine rhinopneumonitis virus as a cause of abortion in mares in new zealand. | 1976 | 190568 | |
| the effect of conjugated estrogens on coagulability in menopausal women. | to investigate the effect of conjugated equine estrogens on the coagulability in menopausal women, blood samples were drawn from 69 menopausal females--35 receiving estrogens and 34 receiving no replacement therapy. using tests for antithrombin and heparin-antithrombin activities, 14.7% of the control patients were found to be hypercoagulable. this is a 289% increase in the incidence of hypercoagulability in the group treated with estrogens. the particular relevance of this finding to menopausal ... | 1977 | 190571 |
| organophosphate inhibitors. the stereospecificity of hydrolysis of methyl n-butyl p-nitrophenyl phosphate by serum phosphotriesterases (ec 3.1.1.2) and by acetylcholinesterases (ec 3.1.1.7). | a chiral phosphotriester, methyl n-butyl p-nitrophenyl phosphate was used to determine the stereospecificity of hydrolysis catalysed by serum phosphotriesterases (aryl-ester hydrolases, ec 3.1.1.2) from horse, ox and rabbit. each enzyme hydrolysed the (-)-enantiomer more quickly. the same phosphate was used to inhibit acetycholinesterase (acetycholine hydrolase, ec 3.1.1.7) from ox, rabbit and electric eel, and in each case, the (+)-enantiomer caused more rapid inhibition. serum phosphotriestera ... | 1977 | 191080 |
| ion binding to lysine-modified derivatives of cytochrome c. | the effect of cl- and k+ ions on the apparent equilibrium constant of the reaction between horse ferricytochrome c and potassium ferrocyanide was studied. unmodified cytochrome was compared with two lysine-modified derivatives. one, guanidinated, had all lysyl groups converted to homoarginine (but retained the same positive charge); the other was trinitrophenylated at one lysine (measured spectrophotometrically). both modified derivatives had a somewhat larger equilibrium constant in the reactio ... | 1977 | 191160 |
| composition and enzyme activities of spiroplasma citri membranes. | spiroplasma citri was cultured in three different media that supplied cholesterol and fatty acids from: (i) horse serum, (ii) pleuropneumonia-like organism (pplo) serum fraction, or (iii) bovine serum albumin-fatty acid-cholesterol. the ability of pplo serum fraction to support growth varied by lot number. neither pplo serum fraction nor the bovine serum albumin medium supported growth as well as the horse serum medium. analysis of cholesterol, lipid phosphorus, and membrane protein showed the h ... | 1977 | 191432 |
| sequential changes associated with the degeneration of preovulatory rat follicles. | in 26-day-old rats, follicles capable of ovulation were present 48 h after pmsg injection and they degenerated if not exposed to an ovulating dose of hcg. in such follicles 125i-labelled lh bound to the thecal and granulosa cells. by 60 h after pmsg, lh binding to the granulosa cells was reduced by 46% although these follicles retained their ability to ovulate. lh binding to the granulosa cells was lost in most follicles by 72 h and ovulation could not be induced. the thecal cells still possesse ... | 1977 | 191604 |
| bovine papilloma virus: presence of virus-specific dna sequences in naturally occurring equine tumors. | four of five spontaneous benign equine connective tissue tumors of unknown etiology and a bovine papilloma virus (bpv)-induced equine tumor contained bpv-specific dna sequences as determined by dna-dna hybridization of dna from tumors with bpv dna labeled in vitro. analysis of the kinetics of reassociation indicated that 20-75% of the bpv genome was present in the various tumors. the number of partial bpv genome equivalents ranged from 60 to 500 copies per diploid quantity of cellular dna. therm ... | 1977 | 191813 |
| equine antibody to bovine serum induced by several equine vaccines as a source of extraneous precipitin lines in the agar gel immunodiffusion test for equine infectious anemia. | precipitin lines not associated with equine infectious anemia (eia) were observed in routine agar gel immunodiffusion (agid) testing for the infection. the serums which produced these lines were obtained from horses which had been given multiple vaccinations with commercially available cell culture-origin equine virus vaccines as part of a comprehensive herd health program. the lines formed against cell culture-derived, but not spleen-derived eia viral antigens. investigation revealed that bovin ... | 1977 | 192111 |
| [superinduction of interferon and and a study of its messenger rna]. | combined use of interferon inductor poly-ic and antibiotics (cycloheximide and actinomycin d) provided a significant increase (up to 1000 times) in interferon production by chick, mouse, monkey and human cells. messenger rna with matrix activity for interferon (mrna-if) was isolated from superinduced cells. on translation of mrna-if in homogenous and heterogenous cells the specificity of interferons produced was determined by the type of the cells from which mrna-if was isolated. sedimentation a ... | 1977 | 192141 |
| a functioning complex between tryptic fragments of cytochrome c. a route to the production of semisynthetic analogues. | we report the discovery of a functioning non-covalent complex between two peptides obtained from a limited tryptic digest of horse heart cytochrome c. we have used the phenomenon to produce three modified versions of the complex. we have replaced lysine-39 semisynthetically with ornithine in the first analogue, with p-fluorophenyl-alanine in the second, and removed it entirely in the third. | 1977 | 192193 |
| stereochemistry of the porphyrin-protein bond of cytochrome c. stereochemical comparison of rhodospirillum rubrum, yeast, and horse heart porphyrins c. | porphyrins c have been obtained from rhodospirillum rubrum cytochrome c2, yeast cytochrome c, and horse heart cytochrome c and compared using proton magnetic resonance and circular dichroism. identity of the spectra establishes that chemically and stereochemically the three porphyrins c are identical. since the stereochemistry of the porphyrin alpha-thioether linkage is not affected in the conversion to porphyrin c, the stereochemistry at the porphyrin alpha-thioether bonds among the correspondi ... | 1977 | 192273 |
| conjugated equine oestrogens and blood clotting: a follow-up report. | a follow-up study of blood clotting and platelet aggregation was performed on 21 women who had received long-term hormone replacement treatment with conjugated equine oestrogens. the prothrombin time and factor vii and x values were significantly accelerated after three months, but there was no further increase with continual administration for 18 months. after 12 to 18 months' treatment, however, thrombin-induced platelet aggregation (chandler's tube) was also significantly accelerated, which s ... | 1977 | 192405 |
| dexamethasone suppression of ovulation in pms-treated immature rats. | a single injection of 2.0 mg/kg dexamethasone (dxm) administered at 51 h after pregnant mare serum gonadatropin (pms) treatment inhibited both ovulation and luteinization. s.c. injection of human chorionic gonadotropin (hgg) caused ovulation and luteinization in dxm-pms-treated rats, whereas treatment with acth failed to overcome the dxm inhibitory effect. these findings are interpreted to indicate that dxm inhibits ovulation through a mechanism which might involve the central nervous system. | 1977 | 192574 |
| binding of avian testicular homogenate with rat follicle stimulating hormone and inhibition of the binding by hypophyseal extracts of lower vertebrates. | 1977 | 192630 | |
| infectious causes of equine respiratory disease on ontario standardbred racetracks. | upper respiratory disease has been a serious problem in standardbred horses on racetracks in ontario, with outbreaks occurring once or twice annually in late winter and early spring seasons. to determine the causes of these epidemics, a 3-year investigation was carried out in which nasal swabs and serum samples were obtained at intervals from apparently healthy horses and from horses suffering from upper respiratory disease. the nasal swabs were used to isolate bacteria and viruses. the serum sa ... | 1977 | 192757 |
| antiproliferative effects of 9-beta-d-arabinofuranosyladenine in a mammalian cell line devoid of adenosine deaminase activity. | the effect of ara-a on cellular growth, dna synthesis, and rna synthesis, and rna synthesis was measured in an established cell line (b-mix k-44/6) devoid of adenosine deaminase activity. cells adapted to growth in a medium supplemented with horse serum provided an environment totally lacking adenosine deaminase activity whereas cultivation of cells in a medium supplemented with calf serum provided a system capable of deaminating ara-a to ara-h (half-life = 14 hours). under deaminase-free condit ... | 1977 | 192768 |
| effects of equine rhinopneumonitis vaccination on an epizootic of race track cough (tracheopharyngitis). | 1977 | 193232 | |
| effect of estrogens on the concentration and composition of arterial sterols and steryl esters in male white carneau pigeons. | the effect of short-term (6 months) administration of conjugated equine estrogen (premarin) on content and composition of the aortic sterols in male shite carneau pigeons while they were on a cholesterol-free grain diet was investigated. estrogen treatment resulted in a 38% increase (p less than 0.05) in free sterol concentration, with a 28.8% concomitant decrease (p less than 0.05) in the percent of cholesteryl esters. the total sterol concentration remained unchanged. this finding suggests tha ... | 1977 | 193527 |
| kinetic studies of the oxidation of horse heart ferrocytochrome c, pseudomonas aeruginosa ferrocytochrome c551, co(terpy)22+, and ru(nh3)5py2+ by tris(1,10-phenanthroline)cobalt(iii) ions. | 1977 | 193881 | |
| studies on equine adenovirus. i. characteristics of an adenovirus isolated from a thoroughbred colt with pneumonia. | 1977 | 194078 | |
| [vaccinations of animals and human health (author's transl)]. | vaccination of animals may have both positive and negative effects on human health. the negative consequences largely occur with live vaccines. the protection provided by vaccination to animals is taken advantage of for human health in the most diverse ways, both directly and indirectly. typical examples are vaccination of dogs and cats against against rabies and inoculation against diseases of cattle, horses and dogs in which reoviruses of serotypes 1, 2 and 3 are involved. an important contrib ... | 1977 | 194146 |
| covalent attachment of peptides to cytochrome c for automated sequence determination. | because small peptides are lost into the organic solvents used, it is virtually impossible to obtain the complete amino acid sequence of a small peptide using only an automated peptide sequencer of the spinning cup type. to overcome this problem we have extended peptides at the carboxy terminus by attachment to equine cytochrome c by a water soluble carbodiimide, relying on the acetylated n-terminus of the cytochrome to minimize its direct contribution to recovery of pth-amino acids. the model p ... | 1977 | 194233 |
| the temperature dependence of the redox potential of horse heart cytochrome c in sodium chloride solutions. | 1976 | 194599 | |
| protective immunity in equine herpesvirus type i infection of hamsters. | 1977 | 194753 | |
| use of n-chlorosuccinimide/urea for the selective cleavage of tryptophanyl peptide bonds in proteins. cytochrome c. | the conditions and utility of the n-chlorosuccinimide/urea (ncs/urea) reagent for the selective cleavage of tryptophanyl peptide bonds in proteins is demonstrated with cytochrome c. at low concentrations of ncs/urea the oxidation of thioether side chains in cytochrome c is the predominant reaction. methionyl residues are oxidized to sulfoxide and the heme-thioether bridge is partially cleaved. at 10-fold excess of ncs/urea reagent, cleavage of the tryptophanyl peptide bond is optimal at approxim ... | 1977 | 194900 |
| variables affecting viral plaque formation in microculture plaque assays using homologous antibody in a liquid overlay. | a liquid antibody microculture plaque assay and the variables that govern its effectiveness are described. the assay is based on the principle that low concentrations of homologous antibody can inhibit secondary plaque formation without inhibiting formation of primary plaques. thus, clear plaques that followed a linear dose response were produced. the assay was found to be more rapid, less cumbersome, and less expensive than assays using agar overlays and larger tissue culture plates. it was rep ... | 1977 | 194918 |
| electron-transfer protein reactivities. kinetic studies of the oxidation of horse heart cytochrome c, chromatium vinosum high potential iron-sulfur protein, pseudomonas aeruginosa azurin, bean plastocyanin, and rhus vernicifera stellacyanin by pentaamminepyridineruthenium(iii). | 1977 | 194940 | |
| temporal changes in ovarian ornithine decarboxylase and cyclic amp in immature rats stimulated by exogenous or endogenous gonadotrophins. | pregnant mare serum gonadotrophin given intravenously to immature rats caused a maximal (x 70) increase in ornithine decarboxylase activity (odc) at 3 h; enzyme activity declined to about ten times the control levels by 9 h and a second rise began after about 20 h. anti-pmsg given 30 min after pmsg reduced the peak response by 70%. actinomycin d, or cycloheximide, completely prevented an increase in odc when given with pmsg, but only cycloheximide lowered the enzyme activity when given 18 h late ... | 1977 | 194994 |
| antiviral activity of some beta-diketones. 1. aryl alkyl diketones. in vitro activity against both rna and dna viruses. | the discovery that 4-[3-ethyl-6-[(3,4-methylenedioxy)phenyl]-3-hexenyl]-3,5-heptanedione (40) exhibited an in vitro inhibitory effect against equine rhinovirus led to a structure--activity study to establish the criteria for optimum activity. modification of the bridge included removal of the ethyl group and reduction of the double bond. the heptanedione was replaced with hexanedione and pentanedione with a minimal effect. the effect of replacing the heptanedione with beta-keto esters and monoke ... | 1977 | 195054 |
| in vitro stimulation of foal lymphocytes with equid herpesvirus 1. | 1977 | 195321 | |
| equine intestinal clostridiosis. an acute disease in horses associated with high intestinal counts of clostridium perfringens type a. | 1977 | 195449 | |
| immunoglobulin g subclass [igg and igg(t)] interaction with the p26 group specific antigen of equine infectious anemia virus: immunodiffusion and complement-fixation reactions. | isolated equine immunoglobulin (ig)g(t) antibodies to equine infectious anemia virus p26 antigen did not precipitate with antigen when the ratio of antibody to antigen was high. however, at lower ratios of antibody to antigen precipitation occurred. in addition, complement-fixation by igg and p26 antigen was inhibited by high concentrations of igg(t). the unusual reaction pattern noted with igg(t) antibodies was still detectable by the immunodiffusion test for equine infectious anemia virus. in ... | 1977 | 195493 |
| equine herpesvirus 1 infection of horses: studies on the experimentally induced neurologic disease. | experimental infection with equine herpesvirus 1 (rhinopneumonitis) resulted in neurologic disease in 8 of 15 inoculated horses. nonpregnant animals did not develop clinical disease, and microscopic examination of tissues revealed no changes. in all mares between 3 and 9 months of gestation, a neurologic syndrome appeared 6 to 8 days after inoculation. mares inoculated when 10 months pregnant did not develop neurologic disorders, but several aborted. the histopathologic change common to both seq ... | 1977 | 195494 |
| [several years of diagnostic studies on the ehv 1 abortion in thoroughbred studs following the introduction of vaccination]. | 1977 | 195571 | |
| kinetic studies on redox reactions of hemoproteins. i. reduction of thermoresistant cytochrome c-552 and horse heart cytochrome c by ferrocyanide. | the oxidation-reduction reaction of horse heart cytochrome c and cytochrome c (552, thermus thermophilus), which is highly thermoresistant, was studied by temperature-jump method. ferrohexacyanide was used as reductant. (formula: see text.) thermodynamic and activation parameters of the reaction obtained for both cytochromes were compared with each other. the results of this showed that (1) the redox potential of cytochrome c-552, + 0.19 v, is markedly less than that of horse heart cytochrome c. ... | 1977 | 195599 |
| gonadotropin action and androgen synthesis in enzyme disperesed testicular cells of the turtle (chrysemys picta). | 1977 | 195861 | |
| protective action of estrogen in endotoxin shock. | protective action of conjugated equine estrogen (cee) against endotoxin shock was admitted in mice. male ddn strain mice pretreated intraperitoneally with 2 mg of cee showed various survival rates according to the interval between administration of cee and endotoxin injection. survival rates of the control were 20.4%, but in the group pretreated with cee they were 0% at 0 hour, 26.3% at 1 hour, 33.3% at 12 hours, 55.7% at 24 hours (p less than 0.001), 10.5% at 36 hours, and 31.2% at 48 hours res ... | 1977 | 196120 |
| respiratory disease in horses. | 1977 | 196170 | |
| sindbis virus-induced cytopathic effect in clones of aedes albopictus (singh) cells. | 1977 | 196393 | |
| virus-induced diabetes mellitus. | 1977 | 196570 | |
| cytochrome c-specific protein methylase iii from neurospora crassa. | a protein methylase iii responsible for specifically methylating the cytochrome c in neurospora crassa was partially characterized by using unmethylated horse heart cytochrome c as a substrate. this enzyme utilizes s-adenosyl-l-methionine as the methyl donor. an analysis of the distribution of [14c]methyl groups in the peptides obtained by chymotrypsin digestion of the enzymically methylated cytochrome c showed that all of the radioactivity could be recovered within a single peak after chromatog ... | 1977 | 196592 |
| the oxidation of ferrocytochrome c in nonbinding buffer. | the apparent equilibrium constant and rate of oxidation was investigated for the reaction of cytochrome c with iron hexacyanide. it was found that if horse heart ferricytochrome c was exposed to ferricyanide (to oxidize traces of reduced protein) the cytochrome subsequently, even after extensive dialysis, had an apparent equilibrium constant different from that of electrodialyzed protein. the effect of ferricyanide ion apparently cannot be removed by ordinary dialysis. the ionic strength depende ... | 1977 | 196725 |
| follicle-stimulating hormone receptors in rat ovaries: decrease in numbers of binding sites associated with luteinization. | 1977 | 196834 | |
| studies on cytochrome c. xii. synthesis of the protected undecapeptide (sequence 66-76) and pentadecapeptide (sequence 66-80) of horse heart cytochrome c. | this paper is part of a series on synthesis of suitably protected peptides covering the 66-104 sequence of horse heart cytochrome c. it describes the preparation, by conventional procedures, of a partially protected n alpha-benzyloxycarbonyl-undecapeptide hydrazide corresponding to the sequence from 66 to 76 (fragment f), which represents a building block for the synthesis of the entire 66-104 sequence. moreover, the preparation is described of a partially protected pentadecapeptide correspondin ... | 1977 | 197034 |
| studies on cytochrome c. xiii. synthesis of the protected undecapeptide (sequence 77-87) of horse heart cytochrome c. | a solution synthesis of z-gly-thr-lys (tfa)-met-ile-phe-ala-gly-ile-lys (tfa)-lys (tfa)-nhnh-boc corresponding to the sequence 77-87 of horse heart cytochrome c is described. the protected undecapeptide was obtained from intermediate hepta- and tetrapeptide fragments by an azide coupling. | 1977 | 197035 |
| studies on cytochrome c. xiv. synthesis of the protected heptadecapeptide (sequence 88-104) of horse heart cytochrome c. | a solution synthesis is described of the partially protected n alpha-benzyloxycarbonylheptadecapeptide z-lys (tfa)-thr-glu-arg-glu-asp-leu-ile-ala-tyr-leu-lys (tfa)-lys (tfa)-ala-thr-asn-glu (obu t)-obu t corresponding to sequence 88-104 of horse heart cytochrome c. the synthesis is achieved through the preparation of two subunits h1 (sequence 88-96) and h2 (sequence 97-104) and their linkage by an azide coupling step. | 1977 | 197036 |
| antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro. | 1-beta-d-arabinofuranosylthymine (ara-t), a metabolite of the sponge tethya crypta, has shown selective activity against herpes simplex virus (hsv) replication (g. a. gentry and j. f. aswell, virology 65:294-296, 1975). analysis of hsv-infected and uninfected cell lysates by cscl isopycnic centrifugation showed that ara-t blocked the incorporation of [(3)h]hypoxanthine into viral deoxyribonucleic acid and, to a large extent, into host deoxyribonucleic acid of infected (but not uninfected) cells. ... | 1977 | 197886 |
| multiple primary tumors in domestic animals: a preliminary view with particular emphasis on tumors in dogs. | cattle, horses, cats, and dogs with microscopically confirmed multiple primary tumors were reported to the veterinary medical data program, a system to collect, store and retrieve veterinary clinical information. of 2611 tumors diagnosed prior to, concurrent with, or subsequent to other tumors during the period studied, 2361 were in 1062 dogs and 250 were in 120 other animals in all other species categories. the 604 multiple primary malignancies (two or more malignant tumors in one animal) were ... | 1977 | 198108 |
| product-inhibition studies with yeast and horse liver alcohol dehydrogenases [proceedings]. | 1977 | 198271 | |
| [allergic reactions in cattle vaccinated against foot-and-mouth disease with vaccines prepared from viruses cultivated in bhk cells in roller bottles]. | tests on bovines vaccinated 3 or 4 times against foot-and-mouth disease with vaccines based on viruses cultivated on bkh cells, in roller bottles, have allowed to define the nature of some of the principal allergens: on the one hand residuary horse serum used to saturate the filters employed in preparing the virus intended for the manufacture of vaccines and, on the other hand, the substances liberated by the cytopathogenic action of the virus on the bhk cells. the horse serum is the most active ... | 1976 | 198319 |
| enrichment medium for the isolation of bordetella. | the development of a specimen collection and transport medium outfit for the rapid laboratory diagnosis of whoping cough is described. the transport medium consisted of a semisolid agar containing charcoal, cephalexin, and defibrinated horse blood. it was also found to be an excellent enrichment medium for the selective isolation of bordetella pertussis and b. parapertussis from scantily populated specimens. the investigation of 3,237 specimens that yielded 1,419 positive isolates of bordetella, ... | 1977 | 198430 |
| synchronous generation of ovarian hcg binding sites and lh-sensitive adenylate cyclase in immature rats following treatment with pregnant mare serum gonadotropin. | a concomitant increase in the activity of lh-senstive adenylate cyclase and in the number of lh/hcg binding sites was induced in ovaries of immature rats upon administration of pregnant mare serum gonadotropin (pmsg), a hormone preparation known to have predominantly follicle stimulation (fsh-like) activity. when an optimal dose of pmsg (15 i.u./rat) was administered to 25-day-old rats, specific activity of lh-dependent adenylate cyclase and the number of binding sites for lh/hcg per mg protein ... | 1977 | 198442 |
| conjugated estrogens and the overnight dexamethasone suppression test. | basal (8:00 am) serum cortisol levels in peri- or postmenopausal women treated with 0.625 mg daily of conjugated equine estrogens were only slightly higher than pretreatment levels. a 1.25 mg/day dosage resulted in a significant increase in basal serum cortisol levels. in women treated with either dosage, 8:00 am serum cortisol levels 8 to 10 hours after 1 mg of oral dexamethasone were suppressed to below 5 microgram/100 ml, although there was a significant rise in post-dexamethasone serum corti ... | 1977 | 198707 |
| [the properties of [omega(3-acetylpyridinio)-n-alkyl]adenosine pyrophosphates, structural analogs of the coenzyme nad (author's transl)]. | [omega-(3-acetylpyridinio)-n-alkyl]adenosine pyrophosphates are coenzyme analogs of nad. the adenosine pyrophosphate moiety and the 3-acetylpyridine ring of the analogs are connected by n-alkyl chains of different lengths (ethyl--hexyl). the analogs form strong dissociating complexes with lactate dehydrogenase. the complex formation is predominantly achieved by interaction of the adp moiety with its respective binding domain at the active site. the redox potentials of the analogs and nad are of ... | 1977 | 198987 |
| the serum levels of progesterone and 20 alpha-dihydroprogesterone, and the ovarian lh, fsh and prl binding during luteolysis of the superluteinized rat ovary. | 1977 | 199009 | |
| pre-ovulatory changes in rat follicular cyclic amp and sensitivity to gonadotrophins. | 1977 | 199017 | |
| equine rhinopneumonitis virus (herpesvirus type 1): attenuation in stable monkey cell line. | an isolate of virulent equine herpesvirus (ehv) type 1 was adapted to vero stable cell line by 13 serial passages at 37 c and 50 serial passages at 26 c. characteristics of the attenuated ehv-1 were found to be avirulent, but immunogenic in horses if injected intramuscularly. the attenuated virus was regularly isolated from peripheral leukocytes in inoculated horses, but was not recovered from nasal turbinate tissues. a mild leukopenia was noticed. the attenuated virus produced characteristic la ... | 1977 | 199093 |
| inactivation of equine infectious anemia virus by chemical disinfectants. | twelve chemicals and commercial disinfectants were tested for inactivation of equine infectious anemia virus. in the presence of 10% bovine serum, all chemicals inactivated 4 log10 (based on 0.1 ml) of the virus within 5 minutes at 23 c. a reduction of at least 4 log10 was observed when the virus was exposed for 1 minute to substituted phenolic disinfectants (3 commercial preparations and sodium orthophenylphenate), halogen derivatives (iodophor and sodium hypochlorite), chlorhexidine, and 70% e ... | 1977 | 199094 |
| stimulatory action of gonadotropins and prostaglandins on adenosine-3',5'-monophosphate production by isolated rat granulosa cells. | 1977 | 199420 | |
| lactoperoxidase-catalyzed iodination of horse cytochrome c:monoiodotyrosyl 74 cytochrome c. | iodination of horse cytochrome c with the lactoperoxidase-hydrogen peroxide-iodide system results initially in the formation of the monoiodotyrosyl 74 derivative. this singly modified protein was obtained in pure form by ion exchange chromatography and preparative column electrophoresis. it shows an intact 695 nm absorption band, the midpoint potential of the native protein, a nuclear magnetic resonance spectrum which indicates an undisturbed heme crevice structure, a normal reaction with antibo ... | 1977 | 199598 |
| characterization of rna from equine infectious anemia virus. | the genome of equine infectious anemia virus, a nononcogenic retrovirus, has been characterized by velocity sedimentation, electrophoresis in polyacrylamide gels, buoyant density in cs2so4, and susceptibility to nuclease digestion. the nucleic acid of purified virus was resolved by sedimentation analysis into a fast-sedimenting genome component, which comprises about two-thirds of the virion rna, and a slow-sedimenting rna, which is probably comprised of host-derived trna and a trace amount of 5 ... | 1977 | 199735 |
| detection of antibody against adenovirus in horses imported into japan. | 1977 | 199777 | |
| [isolation and characteristics of messenger rna for antiviral protein]. | experimental data on the induction and isolation of functionally active mrna's for antiviral protein (avp) from interferon-treated cells are presented. the dynamics of mrna-avp translation in homologous cells and sedimentational distribution of the total and poly(a)-containing preparation of mrna-avp in sucrose density gradients were studied. | 1977 | 200010 |
| suppression of the excitatory adrenergic neurotransmission; a possible role of cholinergic nerves in the retractor penis muscle. | the excitatory adrenergic response to transmural nerve stimulation of the isolated retractor penis (rp) of dog, cat, horse, boar, elk, bull, ram and goat, as well as the evoked release of 3h from dog rp preloaded with 3h-noradrenaline were studied. in untreated preparations a low concentration of scopolamine could markedly increase the excitatory adrenergic response. on the contrary, physostigmine per se suppressed this response and so did acetylcholine. scopolamine or atropine totally prevented ... | 1977 | 200067 |
| effect of hormone replacement therapy on glucose tolerance in postmenopausal women. | oral glucose tolerance tests were performed on 50 symptomatic postmenopausal women before and after three months of hormone replacement therapy. all patients were randomly allocated to one of five groups treated with various synthetic or so-called naturally occurring oestrogens. therapy produced a significant deterioration of carbohydrate tolerance with sequential preparations containing 100 microgram of ethinyl oestradiol or graduated doses of mestranol up to 50 microgram. the conjugated equine ... | 1977 | 200256 |
| [complexes between l (+) lactate: cytochrome c oxidoreductases from the yeasts saccharomyces cerevisiae or hansenula anomala and horse heart cytochrome c]. | 1977 | 200281 | |
| cell mediated immunity in equine herpesvirus type 1 infection i. in vitro lymphocyte blastogenesis and serum neutralization antibody in normal parturient and aborting mares. | blastic transformation of peripheral blood mononuclear cells and serum neutralization antibody levels for equine herpesivurs type 1 were measured in 19 mares from three farms at the time of termination of their pregnancy by normal foaling or viral abortion. the stimulation indexes of lymphocytes obtained from the mares from two farms (farm 1 and 2) which had virus abortions, ranged from 2.1 to 10.8. but there was no significant difference in stimulation index levels between the aborting and norm ... | 1977 | 200317 |
| effect of age and pregnancy on the antibody and cell-mediated immune responses of horses to equine herpesvirus 1. | the cell-mediated immune response and antibody response of horses of varying ages and of pregnant horses to equine herpesvirus 1 antigen were examined. six to eight month old horses showed either no increase or slight increases in anti-equine herpesvirus 1 serum neutralizing antibody following vaccination and revaccination with a modified live equine herpesvirus 1 vaccine. however, these same horses showed a marked increase in the cell-mediated immune response to equine herpesvirus 1 as measured ... | 1977 | 200320 |
| arrhenoblastoma in a mare. | an ovarian neoplasm measuring 10 by 8 by 6 cm was surgically removed from a 14-year-old appaloosa mare. for 2 years prior to surgery, the mare had manifested marked behavioral changes, becoming aggressive toward other broodmares. histologically, the tumor was found to be an arrhenoblastoma. preoperative endocrinologic findings (high serum testosterone and low serum estradiol concentrations) supported the diagnosis. | 1977 | 200593 |
| conformational relaxations of urea- and guanidine hydrochloride-unfolded ferricytochrome c. | several recent studies of protein the unfolded proteins. in urea- and guanidine hcl-unfolded ferricytochrome c (horse heart), an acid-induced spin state transformation of the heme group has been detected by the heme absorptions, trp-59 fluorescence, and the intrinsic viscosity of protein. kinetics of this second conformational transition, by the temperature jump and stopped flow methods, are complex. one rapid reaction (tau1), ph-independent, occurs in a 50-mus range; the second reaction (tau2), ... | 1977 | 200618 |
| the effect of estrogen on endotoxin response. iii. the relationship between doses of conjugated equine estrogen and time course of anti-endotoxic potency (author's transl)]. | 1977 | 200770 | |
| semisynthetic cytochrome c. | horse heart cytochrome c can be split with cyanogen bromide into a heme peptide (residues 1-65) and a nonheme peptide (residues 66-104). in a process involving (i) complex formation between the two fragments and (ii) restoration of the severed peptide linkage, a fully active cytochrome c preparation can be re-formed. use has been made of this process to couple the heme peptide to peptide 66-104 synthesized by the merrifield solid-phase procedure. the semisynthetic product formed in this manner i ... | 1977 | 200910 |
| effect of hypophysectomy on the functions of ovarian mitochondria of mature rats. | 1977 | 200951 | |
| identification of the receptor involved in adrenaline mediated sweating in the horse. | using adrenergic agonists and antagonists this study has demonstrated that adrenaline induced sweating is mediated via beta2-adrenoreceptors in the horse. | 1977 | 200999 |
| phosphatase activity of placental extracts and pregnant mare's plasma. | equine placental extracts show phosphatase activity with a ph optimum between 4.5 and 6. the enzyme shows heat stability to 45 degrees c and electrophoresis on cellulose acetate demonstrates the presence of two bands of activity. histochemistry confirms the presence of phosphatase activity in the placental villi. assay of plasma samples from pregnant mares showed no increase in phosphatase activity through pregnancy under conditions of test. | 1977 | 201000 |
| effect of estrogens on the acitivities of cholesteryl ester synthetase and cholesteryl ester hydrolases in pigeon aorta. | this study is the first to report the effect of conjugated equine estrogens on the acitivity of cholesteryl ester synthetase and cholesteryl ester hydrolases in the aorta. in spontaneously atherosclerosis-susceptible white carneau pigeons, estrogens significantly decreased (p less 0.01) the activity of cholesteryl ester synthetase and increased (p less than 0.01) the cholesteryl ester hydrolase activity in the microsomal fraction of the aorta. there was no effect on the cholesteryl ester hydrola ... | 1977 | 201055 |