Publications

conjugated and unconjugated bilirubins in humans and rhesus monkeys. structural identity of bilirubins from biles and meconiums of newborn humans and rhesus monkeys.	1. bilirubin-ixalpha monoglucuronide was the predominant bilirubin in biles and meconiums of newborn humans and rhesus monkeys. rhesus-monkey baby biles contained slightly more diglucuronide than did human baby biles. 2. bilrubin-ixalpha glucoside, bilirubin-ixalpha xyloside and bilirubin-ixbeta were also constituents of human and rhesus-monkey baby biles and meconiums. bilirubin-ixalpha glucuronide glucoside was present in human and rhesus-monkey baby biles but not in meconiums. the identity of ...	1979	113001
age related changes in serum levels of gonadotropins and testosterone in infantile male rhesus monkeys.		1979	113042
androgen and estrogen metabolism in male rhesus monkeys.	using constant infusions of 3h-labeled androgens and 14c-labeled estrogens, the dynamics of androgen and estrogen metabolism have been studied in male rhesus monkeys. the mean (+/-) mcr, as measured in whole blood, for testosterone (t; 140 +/- 10 liters/day) was significantly smaller than the mcrs for androstenedione (a), estrone (e1), and estradiol (e2; 650 +/- 8, 1010 +/- 160, and 500 +/- 20 liters/day, respectively). these findings are compatible with the specific globulin binding of t in thi ...	1979	113203
[photographic methods for observation of the eye-fundus of rhesus monkeys (author's transl)].	the method for observing the eye-fundus of rhesus monkeys was devised by the use of kowa rc-2 hand-held fundus camera. 1. for monochrome photography, fuji neopan f (asa 32) and fuji neopan ss (asa 100) films were used. the best result was obtained under the following conditions : the strong power pack "50w" x 6 for neopan f and "50w" x 3 for neopan ss. 2. for color photography, fuji color (asa 100 : negative, positive) and sakura color (asa 100 : negative) films were used. the best result were o ...	1979	113227
[preliminary studies on the experimental pcb poisoning in rhesus monkeys (author's transl)].		1979	113313
plasma cortisol levels and dominance in peer groups of rhesus monkey weanlings.		1979	113331
immunization against schistosoma mansoni in rhesus monkeys and the requirement of activation of both cell-mediated and humoral mechanisms.	when groups of rhesus monkeys were pretreated with bcg plus hyperimmune serum from monkeys with chronic schistosomiasis or with dialyzable transfer factor from uninfected monkeys plus hyperimmune serum and were challenged with 1,500 cercariae of schistosoma mansoni, the mean worm burdens were significantly lower than that of untreated controls. pretreatment with neither bcg alone nor corynebacterium parvum plus a membrane antigen of adult worms of s. mansoni affected susceptibility. neither lymp ...	1979	113342
immune responses to schistosoma mansoni in rhesus monkeys with multiple chronic and early primary infections.	immunological reactivity in 10 rhesus monkeys was monitored over a 22-week period. cellular and humoral responses of three animals were studied after primary infection with schistosoma mansoni. two uninfected animals served as controls. increased lymphocyte proliferative responsiveness to mitogens and adult worm antigen was evident during the prepatent period of the infection. marked suppression of these responses occurred during the acute phase of the disease, but by weeks 9 and 11 the animals ...	1979	113343
sites of breakdown of the blood-aqueous barrier after paracentesis of the rhesus monkey eye.	sites of breakdown of the blood-aqueous barrier following rapid paracentesis have been investigated in rhesus monkeys with two independent procedures. (1) the entrance of fluorescein into the anterior and posterior chambers following paracentesis was studied in vivo in normal eyes, in eyes with laser-induced experimental glaucoma, and in totally iridectomized eyes. (2) scanning electron microscopy was used to study the ciliary body and trabecular meshwork regions in normal eyes and paracentetic ...	1979	113359
polychlorinated biphenyls poisoning in monkey eye.	poisoning by polychlorinated biphenyl(s) (pcb) in humans leads to cutaneous and ocular findings. a white, cheeselike secretion issuing from the orifice of the meibomian gland duct when the eyelid is squeezed is one sign of this intoxiation. in the rhesus monkey, abnormal hyperkeratosis of the ductal epithelium was observed histopathologically.	1979	113362
radiographic study of gastric hyperplasia induced by polychlorinated biphenyls in the rhesus monkey.	polychlorinated biphenyls (pcbs) are a group of compounds which have many industrial uses and have become an environmental pollutant. in the rhesus monkey, an unusual type of gastric hyperplasia has been produced by feeding the animals small amounts of these chemicals. by using a double contrast gastrogram with simultaneous pneumoperitoneum, we studied the development of the lesions radiographically. over a period of several months the gastric abnormality progressed from minimal thickening of th ...	1979	113364
pharmacokinetics of iopanoic acid in the rhesus monkey: biliary excretion, plasma protein binding and biotransformation.	a dynamic infusion method, originally developed for the pharmacokinetic studies of iodoxamic acid, was applied to the kinetic studies of the biliary excretion of another cholecystographic agent, iopanoic acid. this dynamic method has an important advantage in that the pharmacokinetic parameters involved in the hepatic uptake or biliary excretion can be evaluated from a single infusion experiment. using the equilibrium dialysis technique, iopanoic acid was found to be highly bound to the plasma p ...	1979	113366
anovulation after pregnancy termination: ovarian versus hypothalamic-pituitary factors.	28 female rhesus monkeys were studied after induced abortion or after spontaneous delivery at term to differentiate ovarian from hypothalamic-pituitary factors responsible for suppression of ovulation. human menopausal gonadotropin (hmg) was administered to stimulate follicular maturation, and estradiol benzoate was injected to test induction of gonadotropin surge. spontaneous ovulation was delayed until about 39 days after abortion. the presence of multiple preovulatory follicles on both ova ...	1979	113424
inferior temporal lesions do not impair discrimination of rotated patterns in monkeys.	ablation of inferior temporal cortex in the rhesus monkey produces a visual discrimination learning deficit. the severity of this deficit has often been found to be a function of task difficulty. this report concerns a type of visual discrimination problem that, although difficult, is not sensitive to inferior temporal lesions. monkeys with anterior, posterior, and complete inferior temporal lesions were repeatedly unimpaired or only slightly impaired in learning to discriminate a pattern from t ...	1978	113428
contrasting effects of lateral striate and superior colliculus lesions on visual discrimination performance in rhesus monkeys.	rhesus monkeys with lesions of lateral striate cortex, monkeys with superior colliculus lesions, and unoperated monkeys were tested for retention of a preoperatively acquired pattern discrimination. the three groups of monkeys were then tested in two-choice, color, color discrimination tests, one involving varying degrees of stimulus-response (s-r) separation and the other, administered several months later, involving various directions of s-r separations. the monkeys were also tested in a serie ...	1979	113429
sensitivity in horseradish peroxidase neurohistochemistry: a comparative and quantitative study of nine methods.	nine currently available methods for hrp neurohistochemistry have been compared with each other on matching tissue sections from four rats and four rhesus monkeys. the nine methods investigated in this report are the diaminobenzidine (dab) procedures of lavail jh and lavail mm (j comp neurol 157:303, 1974), of adams jc (neuroscience 2:141, 1977) and of streit p and reubi jc (brain res 126:530, 1977); the benzidine dihydrochloride (bdhc) procedures of mesulam m-m (j histochem cytochem 24:1273, 19 ...	1979	113450
composition of geniculostriate input ot superior colliculus of the rhesus monkey.	1. in order to examine the composition of the geniculostriate input to the superior colliculus, microelectrode recordings were undertaken in this structure of the rhesus monkey while parvocellular or magnocellular laminae of the lgn were reversibly inactivated by injecting minute quantities of lidocaine or mgcl2. 2. the inactivation of magnocellular laminae disrupted the visually driven activity of most cells in the topographically corresponding areas of the colliculus, but not in the superficia ...	1979	113508
behavioral interaction in social-deprivation-reared macaca mulatta: effects of cerebellar lesions on aggressive and afiliative behaviors.	maintaining isolation-reared adult female macaca mulatta in a group enclosure resulted in rapid resocialization. the influence of cerebellar lesions on social behaviors was most marked on aggressive interactions and cage stereotype pacing and circling.	1979	113535
placental radioangiography as a method for the study of uteroplacental blood flow in the rhesus monkey.	placental radioangiography was performed in lightly anesthetized, pregnant rhesus monkeys under close monitoring of vital signs. two angiographies in the same animal performed at an interval of approximately 20 min consistently produced identical patterns but not at intervals of one or two weeks. evidence is adduced that the parameters, calculated from the angiograms, represent indices of uteroplacental blood flow under the standardized conditions of the angiographic procedure described here. th ...	1979	113538
a radioangiographic study of the effects of catecholamines on uteroplacental blood flow in the rhesus monkey.	two placental radioangiographies were performed with a 20-min interval in ten lightly anesthetized rhesus monkeys. amniotic and aortic pressures, as well as the maternal ecg, were continuously monitored. norepinephrine or metaproterenol was administered in a low dose which did not cause general cardiovascular effects, prior to the second angiography. norepinephrine appeared to cause constriction and metaproterenol, dilatation of the uteroplacental vessels. these effects could be diminished or ab ...	1979	113539
chronic methods to study the release of catecholamines from the neostriatum in nonanaesthetized monkeys (macaca mulatta).	the present report describes two methods allowing the chronic collection of catecholamine (ca) released from the neostriatum in the nonanaesthetized monkey (macaca mulatta). in both methods the monkeys were placed in a restraining chair. indwelling electrodes allowed the correlation of behavioural observations with polygraphic recordings. the first method uses a special superfusing cup permanently implanted on the lateral surface of the caudate nucleus, which permits the demonstration of spontan ...	1979	113547
[electroophthalmological characteristics in ischemic retinopathy (author's transl)].	in the erg the b-wave and the oscillatory potentials are reduced or nonrecordable in ischemic retinopathy. the photopic b-wave appeared to be more sensitive than the scotopic b-wave. in the eog the slow oscillation is reduced. these clinical observations are in accordance with the results of experimental studies in rhesus monkeys.	1979	113610
ultrastructure of normal monkey liver.	the normal ultrastructure of the liver of rhesus and cynomolgus monkeys is described. a classification of type a and b periportal hepatocytes is introduced together with a discussion of the high incidence of mitochondrial abnormalities. it is suggested that the rhesus monkey is more suitable as an experimental model than the cynomolgus since its liver ultrastructure is less variable.	1979	113618
ultrastructure of rhesus monkey renomedullary interstitial cells.	the fine structure of rhesus monkey renomedullary interstitial cells was studied by electron microscopy. these stellate cells contained variable numbers of lipid droplets, moderate numbers of mitochondria, moderate amounts of rough endoplasmic reticulum, and prominent golgi zones. in rare instances, apparent release of lipid droplets into the interstitium was observed. the most prominent feature of the interstitial cells was larger nuclear pseudoinclusions which were observed in a high proportio ...	1979	113623
normal values for some whole blood and serum components of grivet monkeys (cercopithecus aethiops).	normal values for a number of blood components of grivet monkeys are reported. haematological data and values for glucose, cholesterol and urea are similar to those of rhesus monkeys. activities of alkaline phosphatase (1526 u/l), glutamine oxaloacetate transaminase (30.9 u/l), glutamine pyruvate transaminase (13.7 u/l), lactate dehydrogenase (629 u/l), alpha-hydroxybutyrate dehydrogenase (175 u/l), creatine phosphokinase (227 u/l), gamma-glutamyl transpeptidase (38.7 u/l) and sorbitol dehydroge ...	1979	113624
genesis of the primate neostriatum: [3h]thymidine autoradiographic analysis of the time of neuron origin in the rhesus monkey.		1979	113693
maternal-fetal transfer of melatonin in the non-human primate.	melatonin was detected in the circulation of the near-term rhesus monkey (macaca mulatta) and baboon (papio papio) fetus. we determined whether the source could be the mother by studying placental transfer of melatonin in the rhesus monkey. when [3h]melatonin was administered i.v. to the mother it promptly appeared in the fetal circulation; the rates of disappearance of [3h]melatonin in the maternal and fetal circulations were parallel. the rapid decrease in circulating [3h]melatonin was associa ...	1979	113767
ultradian barpressing for rewarding brain stimulation in rhesus monkeys.		1979	113793
the effects of blood sludging upon short-term memory in rats and rhesus monkeys: an evaluation of its role in age-related cognitive declines.		1979	113794
sexual behavior in long-term vasectomized male rhesus monkeys.		1979	113795
experiential variables influencing play, foot-clasp mounting and adult sexual competence in male rhesus monkeys.		1979	113802
genetic analysis of 23 rhl-a histocompatibility antigens of the rhesus monkey.	the lymphocytotoxicity of 116 rhesus monkey alloantisera was evaluated in 92 unrelated rhesus monkeys and in 33 pedigreed rhesus families. the study was conducted using a standard complement-dependent microcytotoxocity assay. a computer-assisted chi2 analysis of the reactivity of these sera in unrelated monkeys generated 23 groups of highly correlated antisera. the two-locus model of the mammalian major histocompatibility complex was assumed for the monkey, and genetic criteria for rhl-a antigen ...	1979	113914
the disposition of [14c]iprindole in man, dog, miniature swine, rhesus monkey and rat.	1. absorption of a single oral dose of [14c]iprindole was rapid in rats, rhesus monkeys, miniature swine, dogs and human volunteers. in all species except the rat, most of the radioactivity in the blood resided in the plasma. small amounts of unchanged iprindole were detected in the plasma of rats and rhesus monkeys but not in man and miniature swine. 2. radioactivity was excreted mainly in the urine of man, miniature swine and rhesus monkey, but in the faeces of rat and dog. 3. urinary radioact ...	1979	113942
transmission of sarcocystis suihominis from humans to swine to nonhuman primates (pan troglodytes, macaca mulatta, macaca irus).	sporocysts of sarcocystis suihominis obtained from human feces were used to infect swine. heart, tongue, and skeletal muscle from experimentally infected and noninfected control swine were fed via stomach tube to nonhuman primates including chimpanzees (pan troglodytes), rhesus monkeys (macaca mulatta), and cynomolgus monkeys (macaca irus). all primates fed infected swine tissues shed sporocysts beginning 13 to 15 days postinfection and were still shedding sporocysts at the conclusion of the exp ...	1979	113949
cortical potentials associated with vocalization in the rhesus monkey.	cortical potentials associated with vocalization have been investigated in two rhesus monkeys. in both animals a slow negative potential shift beginning approximately 1 sec prior to the onset of vocalization has been observed in transcortical recordings from precentral areas. it is suggested that this slow potential change might be the phylogenetic antecedent of the voluntary control of speech in humans.	1977	113982
neuronal-vascular relationships in the raphe nuclei, locus coeruleus, and substantia nigra in primates.	a fluorescence histochemical and electron microscopic study of the monoaminergic cell groups in the squirrel monkey and rhesus monkey brains has revealed the direct apposition of blood vessels to perikarya and dendrites of monoaminergic neurons. capillaries and small arterioles or venules, ranging from 8-50 microns in diameter, showed perikarya and dendrites abutting the basement membrane without evidence of glial interposition. this neuronal-vascular relationship was present in 20% to 30% of th ...	1979	114041
studies on the 2,4-diamino-6 substituted quinazolines. i. antimalarial activities of 2,4-diamino-6-[(3,4-dichlorobenzyl)-nitrosoamino]-quinazoline (ci-679) as exhibited in rhesus monkeys infected with the ro or ro/pm strains of plasmodium cynomolgi.	this report summarizes the results of appraisals of various activities of ci-679 (a 2,4-diamino-6-amino-substituted quinazoline) in rhesus monkeys infected with the ro and ro/pm strains of plasmodium cynomolgi. in subjects inoculated with sporozoites, ci-679, administered in appropriate schedules in doses up to and including the maximum tolerated level, neither prevented development of infections with these strains nor cured those already established. although these evaluations showed that ci-67 ...	1979	114064
sarcocystis in man: a review and report of five cases.	sarcocystis was identified in biopsy specimens of skeletal muscle from two adults in singapore and one in bombay, and in muscle obtained at autopsy from an adult in uganda, and in the heart of a child in costa rica. review of case reports revealed that in seven reported cases, including three reported by lindemann, non-parasite objects were misinterpreted as sarcocysts; in four instances organisms of undetermined classification were described, and in 35 cases true sarcocysts were observed. among ...	1979	114067
characterization of the exfoliative antispermatogenic agent 1-(2,4-dichlorobenzyl)-h-indazole-3-carboxylic acid in the rhesus monkey.	the effects of oral doses of 1-(2,4-dichlorobenzyl)-1h-indazole-3-carboxylic acid (dica) on spermatogenesis in the rhesus monkey (macaca mulatta) was studied. four animals given five daily 50 mg/kg doses or three or five daily 500 mg/kg doses showed that dica was an exfoliating antispermatogenic compound. the inhibition of spermatogenesis was only partially reversible following 500 mg/kg doses of dica. weekly and monthly 50 mg/kg doses of dica only partially inhibiting spermatogenesis as measure ...	1979	114129
the disposition of 3-methyl-2,3-dihydro-9h-isoxazolo[3,2-b]-quinazolin-9-one (w-2451).	3-methyl-2,3-dihydro-9h-isoxazolo[3,2-b]quinazolin-9-one was readily absorbed, metabolized and eliminated in rat, dog, monkey and man. the radioactivity elimination after i.v. or p.o. administration of w-2451-14c in rats was biphasic with corresponding half-lives of 1.8 and 8.7 hours. plasma half-lives of w-2451 in the dog, rhesus monkey and man were 1.4, 1.2 and 3.2 hours, respectively. in the rat, excretion via the urine was predominant, no significant accumulation in tissue occurred. the only ...	1979	114130
pharmacokinetics and metabolism of cefazedone in wistar rat, beagle dog and rhesus monkey.		1979	114189
varied effects of dietary sucrose and cholesterol on serum lipids, lipoproteins and apolipoproteins in rhesus monkeys.	serum lipid, lipoproteins, apolipoproteins and plasma insulin and glucose were studied in rhesus monkeys (macaca mulatta) fed high sucrose diets (69%, w/w), with and without added cholesterol. when compared to basal diet, a high sucrose diet with no added cholesterol fed for 6 weeks increased serum total cholesterol and triglycerides by factors of 1.2 and 2.8, respectively. cholesterol supplementation of sucrose diets increased the serum total cholesterol levels by a factor of 2.2 and decreased ...	1979	114194
hormonal regulation of ovarian folliculogenesis in rhesus monkeys. ii. serum concentrations of estradiol-17 beta and follicle stimulating hormone associated with growth and identification of the preovulatory follicle.		1979	114242
elevation of blood lead concentration by confinement in the rhesus monkey.	rhesus monkeys were exposed to lead (pb) acetate under various regimens during the first 12 months of life. at 30 months of age, these animals and unexposed controls were confined to an unfamiliar experimental chamber for one week. serum cortisol concentration and pb concentration in whole blood (pbb) were measured prior to, during, and after this confinement. cortisol concentrations rose 60--90% within 2 hours of confinement, and declined to baseline levels after 98 hours of confinement. mean b ...	1979	114260
discriminative vocal conditioning in rhesus monkeys: evidence for volitional control?		1979	114270
enhancement of self-stimulation behavior in rats and monkeys after chronic neuroleptic treatment: evidence for mesolimbic supersensitivity.	the effect of chronic neuroleptic drug treatment on self-stimulation of the mesolimbic dopamine system was tested. rats with electrodes implanted into the ventral tegmental nucleus (a10 cell body area) were treated with haloperidol for three weeks. afterwards, the rats showed a 35% increase in self-stimulation rate, as compared to pre-drug control rates. this increase persisted for three weeks after drug withdrawal before returning to baseline rates. rats treated for three weeks with the atypica ...	1979	114275
[stereotype and plasticity of utterances in gibbons (hylobates concolor leucogenys)].	the "great call" of adult male and female hylobates concolor leucogenys was studied in different conditions of social stimulation, using quantitative (i. e. sonographic) analysis. vocal sequences are generally made up of mixed sounds, appearing in a fixed order and constituting a species-specific character. qualitative diversification appears in the repetition of sequences. different social situations alter parameters of the calling pattern: especially the length and intensity of homologous modu ...	1979	114327
treatment of rhesus monkeys (macaca mulatta) with intrauterine devices loaded with levonorgestrel.	the effects of levonorgestrel-loaded plastic intrauterine devices on endometrial morphology were investigated in 15 rhesus monkeys for 14 weeks. the devices were designed to release 25 microgram of the hormone per day and were inserted in the uterus by hysterotomy. control animals were sham operated or received inert placebo devices. with the levonorgestrel-releasing devices, widespread changes in endometrial morphology were seen. these changes included atrophy of the endometrial mucosal and gla ...	1979	114355
clinical experiences with repeated oral administration of l-alpha-acetylmethadol (laam) in the rhesus monkey.		1978	114383
effects of dietary cadmium on rhesus monkeys.	ten male rhesus monkeys, each weighing 3.5 kg, were divided into four groups of 3, 3, 2, and 2, and were fed daily with 100 g pelleted food containing 300, 30, 3, and 0 ppm cadmium, respectively. urine samples were collected every 2 weeks and blood samples every 4 weeks. one monkey each of the 300 and 30 ppm groups was autopsied for pathological examination and tissue cadmium determination at the week 24 of the experiment; the remaining 8 animals were killed after 55 weeks. the lowest exposed gr ...	1979	114386
fusional vergence ranges of the monkey: a behavioral study.	fusional vergence ranges were behaviorally determined for two rhesus monkeys and two human subjects using random dot stereograms as stimuli. the subject performed a two-alternative forced choice form discrimination of discretely presented stimuli and the fusional vergence stimulus was changed during the intertrial intervals. the fusional vergence measurements for the monkey were similar to those for the human subjects.	1979	114404
cortical field of origin of the anterior commissure of the rhesus monkey.		1979	114407
vasectomy: consequences of autoimmunity to sperm antigens.	data from studies examining the effects of vasectomy in a large number of nonhuman primates vasectomized for periods ranging up to 14 years are summarized, and these findings and speculations are used as a framework with which to review the subject of autoimmunity and vasectomy. attention is directed to autoimmunity to sperm antigens following vasectomy (factors affecting antisperm antibody levels, characteristics of circulating antisperm antibodies, antisperm antibodies in seminal plasma, and ...	1979	114428
inhibition of ovarian, placental, and adrenal steroidogenesis in the rhesus monkey by trilostane.	trilostane inhibits adrenal, ovarian, and placental steroidogenesis when administered orally to rhesus monkeys. by inhibiting 3 beta-hydroxysteroid dehydrogenase activity, it causes an increase in circulating levels of pregnenolone. trilostane reverses the stimulation of luteal progesterone production and the delay in onset on menstruation induced by human chorionic gonadotropin. in pregnant monkeys it reduces circulating progesterone levels and is an effective interceptive agent if given for 5 ...	1979	114429
[comparative study of the radiosensitivity of monkey chromosomes in cellular irradiation in vivo and in vitro].	chromosome radiosensitivity was studied in the primary culture of peripheral blood lymphocytes and epithelial kidney cells of macaca mulatta monkeys after gamma-irradiation in vivo and in vitro. the results of the experiments show that there are no differences in aberration yields produced in both types of somatic cells under gamma-irradiation in vivo and in vitro.	1979	114453
the striate projection zone in the superior temporal sulcus of macaca mulatta: location and topographic organization.	in the rhesus monkey, the caudal portion of the superior temporal sulcus (sts) receives a direct projection from lateral striate cortex, the striate are representing central vision. the present study was undertaken to determine whether sts also receives a direct projection from areas of striate cortex representing peripheral vision, with the intent of defining the entire striate projection zone in sts as well as providing information regarding a possible topographic organization within this seco ...	1979	114557
warm fibers innervating palmar and digital skin of the monkey: responses to thermal stimuli.	1. three hundred fourteen warm fibers innervating the glabrous skin of the monkey's hand were isolated by dissection in the median and ulnar nerves in two species, macaca mulatta and m. nemestrina. fiber samples in the two species were functionally similar and uniform in their properties. their mean conduction velocity of 1.2 m/s (sd 0.5; n = 50) implies that these warm fibers were all unmyelinated. 2. a parametric study of the responses of warm fibers to near-rectangular warming and cooling pul ...	1979	114608
antimalarials. 11. synthesis of 3- and 5-aminoquinolines as potential antimalarials.	a series of 3-quinolinediamines (1g, 2c, and 3e) structurally related to primaquine and 4-methylprimaquine have been prepared and tested for antimalarial activity against plasmodium berghei in mice and antileishmanial activity against leishmania donovani in the hamster. all were inactive. in addition, three 5-quinolinediamines (4b, 5, and 6) were prepared. all were inactive against leishmania donovani in hamsters. one of the examples, 6, was curative against plasmodium cynmolgi in the rhesus mon ...	1979	114654
central sites controlling pituitary secretion in the rhesus monkey.		1979	114716
association of tritiated ovarian steroids with the rhesus monkey brain.		1979	114717
experimental arteriosclerosis in rhesus monkeys induced by multiple risk factors: cholesterol, vitamin d, and nictotine.	forty-four rhesus monkeys were given various regimens involving three vasotoxic factors: dietary hypercholesteremia, hypervitaminosis d2 and nicotinism for period ranging from 14 to 62 weeks. when administered singly, no or only early disease was observed. the combined three "risk factor" group demonstrated the most impressive arteriosclerosis. major arteriosclerotic changes: fat, calcium and mensenchyme of thirty standardized segments of aorta, coronary and limb arteries of all monkeys were gra ...	1979	114963
comparison of behavioral effects of systemic l-dopa and intracranial dopamine in mesolimbic forebrain of nonhuman primates.	the systemic administration of l-dopa and carbidopa to six rhesus and four squirrel monkeys produced an initial period of depressed activity followed by increased locomotion, hypervigilance, involuntary oral-facial movements and a gnawing syndrome. the squirrel monkey exhibited a depressed phase, locomotor stimulation, searching behavior, stereotypic grooming and gnawing syndrome. most of these activities were prevented by pretreatment with 0.1 mg/kg haloperidol. bilateral injection of 100 micro ...	1979	115011
reversal learning deficits in young monkeys exposed to lead.	the reversal learning capacity of young rhesus monkeys in visual discrimination tasks was examined during daily exposure to dietary lead acetate throughout the first year of life. while not affected in physical development, all lead-treated monkeys showed performance deficits on reversal learning tasks. these deficits were independent of lead-induced changes in motivation. over a series of problems, the overall learning rate of monkeys with blood lead concentrations in the range of 70-90 microgr ...	1979	115012
ethanol drinking by rhesus monkeys with concurrent access to water.	three monkeys were provided concurrent access to water and ethanol in concentrations of either 8, 16 or 32% (w/v) during daily 3-hr sessions. the monkeys were those for whom ethanol had been established as a reinforcer in an earlier study in which only ethanol or water was available. ethanol was preferred to water at all concentrations and volume of ethanol consumed was inversely related to ethanol concentration. quantity of ethanol (g/kg of body wt.) consumed remained relatively constant, and b ...	1979	115013
effects of response-contingent clock stimuli on behavior maintained by intravenous codeine in the rhesus monkey.	response-contingent brief presentations of clock stimuli differentially correlated with food availability altered rates of codeine-maintained lever pressing. rhesus monkeys performed under a two lever multiple schedule: multiple fixed interval clock 5 min variable interval 2 min. different colored lights were presented during successive 75 sec period of the fixed-interval clock component. lever pressing under the fi clock schedule was maintained by presentation of 1 g noyes pellets, and lever pr ...	1979	115015
an improved method for embedding brain tissue in albumin-gelatin.	a new modification of the snodgrass-dorsey (1963) albumin embedding method is described. formalin fixed brains of various ages of rhesus monkey (macaca mulatta) were sunk in 10% phosphate buffered formalin which contained 30% sucrose, and then embedded in a 3% gelatin, 30% egg albumin solution which had been centrifuged to ensure uniformity. the albumin-gelatin was hardened in formaldehyde fumes and blocks cut frozen at 10-40 micron. sections thus prepared can be handled easily and mounted witho ...	1979	115116
intercellular junctions in the rhesus monkey pars distalis.	four rhesus monkey pituitary glands were examined by transmission electron microscopy. three types of intercellular junctions, desmosomes, hemidesmosomes and zonula adherens-type junctions, were observed between adjacent granular cells, folliculo-stellate cells, and joining a folliculo-stellate cell with a granular cell. demosomes were most commonly observed between granular cells while the zonula adherens-type junctions were generally found between the folliculo-stellate cells.	1979	115336
bile studies after liver transplantation.	an analysis of bile composition following orthotopic liver transplantation in the rhesus monkey showed that during rejection only small quantities of viscid bile were produced and that this was associated with increased cholesterol saturation. bile composition in patients after liver transplantation also showed that bile was supersaturated with cholesterol in the early postoperative period while the enterohepatic circulation of bile acids was interrupted by a draining t tube. however, further st ...	1979	115368
[identity of karyotypes of papio papio and macaca mulatta in r, g, c banding and ag-nor].		1978	115371
suprathreshold retinal damage due to single 6 picosecond 1060 nm laser light pulses.	the retinas of rhesus monkeys were exposed to 6 ps laser light pulses at 1060 nm at 62 and 95 muj. lesions were examined by light and transmission and scanning electron microscopy. evidence of damage was seen in all retinal layers, being most severe in the photoreceptor inner and outer segments. in addition to damage mechanisms previously proposed, it is suggested that the peak power flux density achieved with extremely short pulses may lead to some absorbance by inner retinal layers.	1979	115454
measurement of spatial behavior: methodology applied to rhesus monkeys, neon tetras, communal and solitary spiders, cockroaches, and gnats in open fields.		1979	115455
reinforcing properties of nicocodine in the rhesus monkey.	the present study demonstrates that nicocodine is self-administered by the rhesus monkey in cross self-administration experiments. the minimum reinforcing dose is 10 times higher than that of codeine and 100 times higher than that of heroin. at reinforcing doses the rate of self-administered infusions of nicocodine is comparable with those of codeine. further experiments are necessary to rank order nicocodine as to its positive reinforcing properties among the opiate-like compounds. on the other ...	1979	115478
application of linear system analysis to the horizontal vestibulo-ocular reflex of the alert rhesus monkey using pseudorandom binary sequence and single frequency sinusoidal stimulation.	horizontal eye movements of the alert rhesus monkey resulting from both pseudorandom binary sequence (prbs) and single frequency sinusoidal rotational stimulation were analyzed using a pdp 11/40 computer in order to generate gain, phase, and coherence estimates at discrete frequencies between 0.008 and 1.28 hz. a computer simulation of vestibular induced eye movements was used to validate our analysis procedures and to determine the effects of digital noise. frequency domain transfer functions d ...	1979	115503
sexual behavior in male rhesus monkeys elicited by electrical stimulation of preoptic and hypothalamic areas.	electrical stimulation of the preoptic area, lateral hypothalamus or dorsomedial nucleus of the hypothalamus (dmh) has produced sexual behavioral responses in 11 male rhesus monkeys. at a short latency following the onset of each train of stimulation, the stimulated males would mount estrogen-treated, receptive females. quantitative measures of the elicited sexual behavior, in 4 males, were applied to describe differences between the effect of preoptic and dmh stimulation on male sexual performa ...	1979	115544
vestibular projections to the monkey thalamus: an autoradiographic study.	vestibulothalamic projections were studied in the monkey (macaca mulatta) by injecting anerograde trace substances (radioactive leucine and proline) into the vestibular nuclear complex. terminal labelling was found bilaterally mainly in the nucleus ventroposterior lateralis pars oralis (vplo) and to a lesser extent in the nucleus ventroposterior inferior (vpi) and nucleus ventralis lateralis pars caudalis (vlc). the labelling was sparse, and scattered over wide areas. the vestibular origin of th ...	1979	115546
renal tubular transport of methotrexate in the rhesus monkey and dog.	the mechanism and localization of renal transport of methotrexate (mtx) were studied in the rhesus monkey and the dog. it was found that in both animals mtx was bound with plasma protein in a range of 50 to 68% varying with the mtx plasma concentration. paper chromatographic analysis showed that a negligible amount of mtx was metabolized. the excretion of mtx in rhesus monkey was mainly by tubular secretion which was blocked by probenecid, but in the dog a bidirectional transport mechanism for m ...	1979	115582
the subcellular distribution of gold in monkey liver, kidney and spleen, in vivo.	1. the subcellular distribution of gold in the livers, kidney cortex and the spleens of rhesus monkeys was determined at 2, 10 and 20 days after the administration of sodium (195au)-aurothiomalate. the serum gold levels were also determined over the period of study. 2. with the continued decrease in the serum gold levels from day 1 to day 20, a continued increase in the tissue levels of the organs studied was observed. the corresponding subcellular fractions of the tissues also showed continued ...	1979	115629
comparative aspects of blastocyst-endometrial interactions at implantation.	since the trophoblast-uterine adhesion is as nearly a universal phenomenon in implantation as can be found, an attempt was made to determine whether or not there was a reduction in cell surface glycoproteins in the rat, as can be observed in the ferret. neither colloidal iron nor cationized ferritin revealed the type of pattern anticipated for a localized reduction in surface negativity in the imprint of the blastocyst in the implantation chamber. the use of lectin-coated latex beads also proved ...	1978	115657
immunological interference with the maternal recognition of pregnancy in primates.	if chorionic gonadotropin is involved, as part of the luteotrophic stimulus, in the maternal recognition of pregnancy in primates, then immunization against the beta subunit of hcg should prevent a conception going beyond the length of the normal cycle. immunization against hcg-beta suppresses fertility in marmoset monkeys, baboons and rhesus monkeys, as long as the antibody titres remained high. as titres decline, however, female marmosets experience recurrent abortions interspersed with occasi ...	1978	115658
twenty-four-hour patterns in serum prolactin and cortisol after partial and complete isolation of the hypothalamic-pituitary unit in rhesus monkeys.		1979	115669
the pattern of urinary excretion of corticosteroids in rhesus monkeys (macaca mulatta).	urinary total 17-oxogenic steroids (17-ogs), cortisol, cortisone, corticosterone, tetrahydrocortisol (thf), allo-tetrahydrocortisol (all-thf), tetrahydrocortisone (the), cortols and cortolones, were estimated by established methods in 30 female and 20 male rhesus monkeys. the pattern of the excretion of these steroids in this species was comparable with the human corticosteroids excretion, irrespective of sex difference. the results obtained from this investigation show that they could be used d ...	1979	115672
the velocity response of vestibular nucleus neurons during vestibular, visual, and combined angular acceleration.	in alert rhesus monkeys neuronal activity in the vestibular nuclei was measured during horizontal angular acceleration in darkness, acceleration of an optokinetic stimulus, and combined visual-vestibular stimulation. the working ranges for visual input velocity and acceleration extend up to 60 degrees/s and 5 degrees/s2. the corresponding working range for vestibular input acceleration is wider and time-dependent. during combined stimulation, that is acceleration of the monkey in the light, a li ...	1979	115704
acute decreases in serum prolactin concentrations caused by delta 9-tetrahydrocannabinol in nonhuman primates.	the acute effects of single injections of delta 9-tetrahydrocannabinol (thc) on serum prolactin (prl) concentrations were studied in oophorectomized female and intact adult male rhesus monkeys. some animals were challenged with thyrotropin-releasing hormone (trh) to determine whether thc influences pituitary responsiveness to releasing hormone. thc markedly suppresses serum prl concentrations in animals of both sexes. trh injections resulted in normal prl release when administered simultaneously ...	1979	115723
effects of delta 9-tetraphydrocannabinol administration on gonadal steroidogenic activity in vivo.	the effects of delta 9-tetrahydrocannabinol (thc) administration on gonadal steroidogenic activity in vivo were studied in two animal models: (1) luteal function of the rhesus monkey and (2) periovulatory steroid concentrations of rabbits treated with human chorionic gonadotropin (hcg). thc-treated monkeys demonstrated progesterone concentrations and luteal phase lengths which were not different from those in untreated controls. thc did not impair the normal pattern of response of the corpus lut ...	1979	115724
immune response after vaginal application of antigens in the rhesus monkey.	the immune response after vaginal application of antigens was investigated in six sexually mature female rhesus monkeys. two model antigens, i.e., lipopolysaccharide (lps) of salmonella typhosa and abortive type t-4 coliphages were applied with or without adjuvant. a plastic sponge used as the antigen carrier was introduced into the upper vagina and placed against the ectocervix. for primary immunization, each monkey received 18 vaginal antigen applications and 10 applications for each booster ...	1979	115725
characterization and biosynthesis of proteoglycans of corneal stroma from rhesus monkey.	the proteoglycans of the rhesus monkey corneal stroma were characterized by analyzing both radiolabeled proteoglycans synthesized by corneas in organ culture and native corneal proteoglycans obtained by large scale preparations. the analyses indicate that the proteoglycans synthesized in organ culture were similar to, if not identical with, their counterparts in the stroma although they are synthesized in different prportions in vitro than they acumulate in vivo. the corneal stroma contains two ...	1979	115885
projections of the cerebellar and dorsal column nuclei upon the inferior olive in the rhesus monkey: an autoradiographic study.	projections from the cerebellar and dorsal column nuclei to the inferior olive of the rhesus monkey were traced with anterograde autoradiographic methods. the cerebellar nuclei give rise to a massive projection which reaches the contralateral inferior olivary complex by way of the descending limb of the superior cerebellar peduncle. dentato-olivary fibers project exclusively upon the principal olivary nucleus (po) and observe a strict topography. the dorsal, lateral, and ventral dentate project ...	1979	115909
experimental delayed radiation necrosis of the brain. part 1: effect of early dexamethasone treatment.	the authors have designed an experiment to detect a hitherto unrecognized interaction between high doses of the glucocorticoid, dexamethasone, and brain irradiation. eighteen juvenile male rhesus monkeys received 1800 rads to the whole brain in 8.5 minutes. for 1 1/2 days before and 10 1/2 days after the irradiation, nine animals received approximately 2.9 mg/kg/day of dexamethasone intramuscularly in addition to irradiation, while the remaining nine animals served as the control group and recei ...	1979	115970
cryosurgery of major and minor salivary gland: a light microscopic evaluation in the rhesus monkey.	the minor salivary glands in the hard palate and the submandibular gland of the rhesus monkey were subjected to a liquid nitrogen, direct-spray, one-cycle freeze. a 4-min freeze in the temperature range of -40 degrees c to -60 degrees c was used. the extent of tissue destruction was determined at intervals up to 1 year. clinically relevant findings resulted and form the basis for subsequent studies by this group of investigators.	1979	115981
pharmacologic characterization of isolated rhesus monkey bronchial smooth muscle.		1979	115993
the effects of cooling globus pallidus on manual tracking in trained rhesus monkeys [proceedings].		1979	115995
establishing a free-ranging breeding colony of rhesus monkeys. part i.	the caribbean primate research center recently contracted with the food and drug administration to establish a free-ranging island breeding colony of rhesus monkeys. the goal of the program is to produce 600 to 800 offspring yearly from 1,000 breeding age females. the initial colony stock will consist of approximately 360 animals from an existing colony that was established on an island off the southwestern coast of puerto rico in 1961. expansion of the colony will be accomplished by the purchas ...	1979	116000
clinical appearance of the hyaloid artery system in the newborn rhesus monkey.	fifteen healthy newborn rhesus monkeys (macaca mulatta) were given funduscopic examinations as part of a screening process before utilization in a research project. the hyaloid vasculature, a system that supplies blood to the embryonic ocular structures, was observed in each subject and was noted to regress clinically at two to three weeks of age. although the phenomenon has been described morphologically in the literature, its clinical appearance has not been illustrated for the primate clinici ...	1979	116004
clinical utilization of mechanical sutures for intestinal anastomosis in macaca mulatta.	using three mechanical stapling instruments that employ stainless steel wire staples, a mann-bollman fistula was created on the terminal ileum in 27 rhesus monkeys (macaca mulatta). two functional end-to-end anastomoses were accomplished and an ileostium constructed. staples of various sizes were used; it was found that pediatric-sized staples were necessary for the intestinal tissue of these primates. six months after surgery, microscopic examination revealed encapsulation of the staples by gra ...	1979	116072
the effects of methamphetamine on fine motor control in rhesus monkeys.	six rhesus monkeys were trained to extend their arms through a tube to press a lever with between 25 and 40 g of force for 3 or 5 sec. responding was maintained by the delivery of 1.5 cc of water. stimulus lights indicated whether the exerted force was below 25 g. between 25 and 40 g (i.e., correct) or above 40 g. sessions were terminated after 50 water deliveries or 30 min had elapsed. performance was well-maintained in all monkeys. allowing the animals access to water prior to the session had ...	1979	116246
effects of an enkephalin analog on complex learning in the rhesus monkey.	facilitation of the learning of a discrimination reversal task for a reward of food was found in rhesus monkeys after subcutaneous administration of a potent pentafluorinated enkephalin analog. (d-ala2)-f5-phe4-enkephalin-nh2. general activity, short-term memory, startle, and analgesia, however, were not significantly affected. in a within-subject design, each of 6 monkeys (3 males and 3 females) received each of 5 doses of the enkephalin analog (0.1, 1, 10, 100, and 1,000 microgram/kg). one dai ...	1979	116247
behavioral effects of stimulating positive reward sites in the central tegmentum of rhesus monkeys.		1979	116261
cocaine, d-amphetamine, and pentobarbital effects on responding maintained by food or cocaine in rhesus monkeys.	the effects of im injections of cocaine, d-amphetamine, and pentobarbital were studied in rhesus monkeys whose lever-press responding was maintained under a second-order fixed-interval, fixed ratio schedule of reinforcement. within each session, fixed-interval components, ending with the iv injection of 30 microgram/kg cocaine (one group of monkeys) or the delivery of a 300 mg food pellet (second group of monkeys), alternated with fixed-interval components ending without an injection of cocaine ...	1979	116268
brain blood flow and metabolism after global ischemia and post-insult thiopental therapy in monkeys.	we measured total and regional cerebral blood flow (cbf, rcbf) and cerebral metabolic rate (cmr) of oxygen (o2), glucose (g), and lactate (l) levels for 4 h after 16 min global brain ischemia in rhesus monkeys with and without post-insult thiopental therapy. eleven monkeys weighing 4-5 kg anesthetized with 1 percent halothane, 66 percent nitrous oxide and 33 percent oxygen, were subjected to 16 min global brain ischemia by a combination of trimethaphan hypotension (to a mean arterial pressure of ...	1979	116395
effects of biorhythms on blood flow distribution in the pregnant uterus (macaca mulatta).	ten rhesus monkeys were studied between 143 and 161 days of gestation. the unanesthetized animals were confined to restraining chairs and maintained in a controlled environment with continuous monitoring of spontaneous uterine dynamics. forty-five determinations of blood flow distribution were made using radionuclide-labeled microspheres. the microsphere injections confirmed a circadian pattern of uterine blood flow. these biorhythms are related to alterations in distribution of blood flow to pl ...	1979	116548