Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| allergic encephalomyelitis in common marmosets: pathogenesis of a multiple sclerosis-like lesion | experimental allergic encephalomyelitis (eae) is an autoimmune disease of the central nervous system that has been extensively studied as a model for the human demyelinating disease multiple sclerosis (ms). here we describe the characteristics of a novel form of eae developed in a nonhuman primate. in callithrix jacchus marmosets (c. jacchus), immunization with whole brain white matter induces a primary demyelinating disease with a relapsing-remitting chronic course, closely resembling human ms. ... | 1996 | 8954853 |
| the potential of the zona pellucida as a target for immunocontraception. | to investigate the contraceptive potential of the zona pellucida. | 1996 | 8962643 |
| evaluation of zona pellucida antigens as potential candidates for immunocontraception. | antibodies directed against the zona pellucida can interrupt sperm-egg recognition in vitro. however, the mechanisms by which anti-zona antibodies exert this contraceptive effect in vivo remain uncertain. there is an accumulating body of evidence to suggest that active immunity against zona antigens not only induces infertility via an antibody-mediated interruption of sperm--egg interaction but also disrupts normal ovarian function. we have evaluated the consequence of inducing active immunity a ... | 1996 | 8984181 |
| immunocytochemical localization of zp3 in primordial follicles of rabbit, marmoset, rhesus monkey and human ovaries using antibodies against human zp3. | active immunization with zona pellucida (zp) proteins leads to depletion of primordial and recruited follicles in the ovary by a yet unknown mechanism. small amounts of zp present on primordial follicles or granulosa cells may be one of the reasons for this ovarian pathology. this study was undertaken in an attempt to identify the presence of zp in or on primordial follicles and granulosa cells in ovaries of rabbits, common marmosets (callithrix jacchus), rhesus monkeys (macacas mulatta) and hum ... | 1996 | 8984187 |
| parallel processing in cerebral cortex of the marmoset monkey: effect of reversible si inactivation on tactile responses in sii. | 1. responsiveness within the hand region of the second somatosensory area of cortex (sii) was investigated in the marmoset monkey (callithrix jacchus) in association with cooling-induced, reversible inactivation of the primary somatosensory area, si. the aims were to determine whether thalamocortical systems in this primate species are organized according to a serial scheme in which tactile information is conveyed from the thalamus to si and thence to sii as the next hierarchical level of proces ... | 1996 | 8985863 |
| cardiac-like musculature of the intrapulmonary venous wall of the long-clawed shrew (sorex unguiculatus), common tree shrew (tupaia glis) and common marmoset (callithrix jacchus). | the cardiac-like musculature is distributed not only in the heart wall but also in the intrapulmonary venous wall in a few species of insectivores. it has been suggested that the evolutionary origin of venous cardiac-like musculature may be traceable to a basic stock of certain mammalian lines of descent. so, it is important to clarify whether the musculature may be a common structure in lower mammals from insectivores to primates and to examine the functional significance of the structure. | 1997 | 8986302 |
| occurrence of an infanticide within a captive polygynous group of common marmosets, callithrix jacchus. | 1996 | 8990517 | |
| clinical pathologic changes in two marmosets with wasting syndrome. | two sexually mature marmosets (callithrix jacchus) showing clinical signs similar to those seen in wasting marmoset syndrome (weight loss, decreased muscle mass, and alopecia) were evaluated for clinical and anatomic pathologic changes. the most prominent clinical pathologic alterations included macrocytic normochromic anemia, hypoproteinemia, hypoalbuminemia, elevated serum aspartate aminotransferase and alkaline phosphatase levels, and previously unreported changes of thrombocytosis. the princ ... | 2017 | 8994297 |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal level. | the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) has been shown to induce parkinsonism in man and non-human primates. hypotheses concerning the mechanism of action of mptp have been related to the pathogenesis of nigral cell death in parkinson's disease. for instance, alterations of calcium influxes have been reported to be implicated in both mptp-induced parkinsonism and parkinson's disease. recently, we reported that nimodipine, a blocker of l-type calcium channels, prevents ... | 1996 | 9001722 |
| characterization of the tcrb chain repertoire in the new world monkey callithrix jacchus. | callithrix jacchus is an outbred new world primate characterized by a naturally occurring bone marrow chimerism, restricted polymorphism at many mhc loci, and unusual susceptibility to viral pathogens, adenocarcinoma, colitis, and, following immunization with myelin antigens, a demyelinating disease of the central nervous system closely resembling human multiple sclerosis. here we characterize the tcrb repertoire in this species, representing the first such analysis in a new world monkey. two tc ... | 1997 | 9013960 |
| location and developmental regulation of androgen receptor in primate ovary. | locally produced androgens act via granulosa cell androgen receptors to modulate follicular responsiveness to gonadotrophins and thereby contribute to the paracrine regulation of ovarian function. we used quantitative androgen receptor immunocytochemistry to assess androgen receptor distribution in relation to pre-ovulatory follicular development in the common marmoset (callithrix jacchus), a new world primate that ovulates two to four follicles in each approximately 28 day ovarian cycle. ovarie ... | 1997 | 9043913 |
| age of epiphyseal closure in tamarins and marmosets. | estimates of the chronological age for animals of unknown age provide useful information for medical, demographic, and evolutionary studies. skeletal development, as indicated by epiphyseal closure, can be used to estimate an animal's chronological age or specify its stage of development. many studies of primate skeletal development have used animals of unknown age, with the order of epiphyseal closure providing a relative age for each animal. this study examines the age of epiphyseal closure at ... | 1997 | 9050370 |
| morphological analysis of the blue cone pathway in the retina of a new world monkey, the marmoset callithrix jacchus. | we have studied the components of the short wavelength-sensitive (sws or "blue") cone pathway in the retina of a new world primate, the marmoset callithrix jacchus. of particular interest was the small bistratified ganglion cell, which has been identified in macaque monkey to be the morphological substrate of the blue-on cell (dacey and lee [1994] nature 367:731-735). small bistratified cells were intracellularly filled with neurobiotin in an in vitro retinal wholemount preparation. their morpho ... | 1997 | 9050786 |
| the morphology and distribution of horizontal cells in the retina of a new world monkey, the marmoset callithrix jacchus: a comparison with macaque monkey. | the morphology and distribution of horizontal cells was studied in the retina of a new world monkey, the marmoset, callithrix jacchus, and compared with that of the old world macaque monkey. horizontal cells in macaque and marmoset were either labelled with the carbocyanine dye, dii, and then photoconverted, or were labelled by intracellular injection with neurobiotin. the marmoset has two types of horizontal cell, h1 and h2, which have dendritic and axonal morphology similar to their counterpar ... | 1997 | 9057275 |
| familial influences on ovulatory function in common marmosets (callithrix jacchus). | previous studies have indicated that many, but not all, female common marmosets (callithrix jacchus) housed with their natal families undergo social suppression of ovulation. in this study, we further characterized ovulatory activity in common marmoset daughters to determine the prevalence of social suppression of ovulation and to elucidate familial influences on daughters' ovarian activity. blood samples were collected twice weekly from each of 46 daughters for 5-12 months, usually beginning wh ... | 1997 | 9057963 |
| development of an enzyme-immunoassay (eia) for the measurement of follicle-stimulating-hormone (fsh) in callitrichid primates using a monoclonal antibody against the human-fsh-beta-subunit. | despite the importance of callitrichid primates in both biomedical and conservation research, practical and reliable immunoassays for the measurement of follicle-stimulating hormone (fsh) have not yet been described. a panel of monoclonal antibodies against specific peptide fragments within either the alpha or beta subunit of human fsh was evaluated for their ability to recognize fsh from callitrichid and other new world primates. one of these, monoclonal antibody 46.3h6.b7 raised against human ... | 1997 | 9057964 |
| behavioral and social correlates of escape from suppression of ovulation in female common marmosets housed with the natal family. | although female common marmosets typically do not breed while housed with their natal families, up to half ovulate at least once while housed with the intact natal family, and a similar proportion conceive if an unrelated adult male is present in the group. in this study, we investigated the behavioral and social correlates of escape from suppression of ovulation by daughters housed in intact natal families or in families in which the father had been replaced by an unrelated adult male. focal-an ... | 1997 | 9064194 |
| birth of offspring following artificial insemination in the common marmoset, callithrix jacchus. | the objective of the study was to develop a method for artificial insemination (ai) in the common marmoset, a new world primate species. for ai to be successful, sperm must be deposited at an appropriate site and time in the female reproductive tract, details of which are currently not available for callitrichid species. epididymal sperm were deposited in the cervix of 18 marmoset monkeys (callithrix jacchus) around the time of expected ovulation using either 3, 2, or 1 inseminations. six out of ... | 1997 | 9064196 |
| comparative chromosomal study of five taxa of genus callithrix, group jacchus (platyrrhini, primates). | the karyotypes of four marmoset species of the callithrix jacchus group (c. aurita, c. kuhlii, c. geoffroyi, and c. penicillata) were investigated. the patterns of g-, c-, and nor-bands of these karyotypes were compared with those of c. jacchus, previously described, in order to clarify the taxonomic relationships of this species group. all species present 2n = 46, 14 uni- and 30 biarmed autosomes, a median size submetacentric x chromosome, and the same nor-band patterns. no rearrangement or con ... | 1997 | 9064198 |
| comparative study on age-dependent development of surface receptors on peripheral blood lymphocytes in children and young nonhuman primates (marmosets). | general conformity was found concerning age-dependent changes in the major subsets (cd4, cd8, cd2, cd20) and the adhesion molecules cd11a and cd29 on peripheral blood lymphocytes in children and young marmosets (callithrix jacchus). differences exist in the expression of the surface receptors cd45ra and cd56. taking the total number of white blood cells into account, an age-related increase in the absolute numbers of peripheral blood lymphocytes was found in marmosets whereas in children, an age ... | 1997 | 9064482 |
| competition and chemical communication in wild groups of common marmosets (callithrix jacchus). | 1997 | 9071391 | |
| escape from social suppression of sexual behavior and of ovulation in female common marmosets. | 1997 | 9071400 | |
| brain-stem auditory evoked potentials in the common marmoset (callithrix jacchus). | brain-stem auditory evoked potentials (baeps) were recorded in 10 common marmosets (callithrix jacchus) to investigate the effects of recording electrode configurations, stimulus rate, and stimulus frequency on baep wave forms and peak latencies. tone burst stimulations were used to evaluate the effects of pure tone on baep wave forms. five positive peaks superimposed on positive and negative slow potentials were identified in the baep recorded at the linkage between the vertex and the dorsal ba ... | 1997 | 9076252 |
| functional characterization and purification of an intracellular vitamin d-binding protein in vitamin d-resistant new world primate cells. amino acid sequence homology with proteins in the hsp-70 family. | most genera of new world primates exhibit resistance to vitamin d. these monkeys harbor high circulating concentrations of the prohormone 25-hydroxyvitamin d and the active vitamin d hormone 1, 25-dihydroxyvitamin d. previous work from this laboratory indicated that resistance is associated with the overexpression of a 60-65-kda intracellular protein that binds vitamin d metabolites competitively. in the current studies 25-[3h]hydroxyvitamin d3 (25-ohd3) was used as a competitive ligand to inves ... | 1997 | 9079669 |
| creation of a model for multiple sclerosis in callithrix jacchus marmosets. | multiple sclerosis (ms) is an inflammatory disease of the cns white matter characterized pathologically by the accumulation of perivascular and parenchymal t lymphocytes (t cells), and macrophage infiltration associated with myelin destruction. ms lesions are also characterized by the death of oligodendrocytes (the myelin-producing cells) and proliferation and hypertrophy of astrocytes with scar tissue (gliosis) replacing normal myelin. these changes result in the loss of axonal conduction for n ... | 1997 | 9106075 |
| toxoplasmosis in a colony of new world monkeys. | in a colony of new world monkeys five tamarins (saguinus oedipus, saguinus labiatus and leontopithecus rosal. rosal.), three marmosets (callithrix jacchus and callithrix pygmaea) and one saki (pithecia pithecia) died suddenly. the colony comprised 16 marmosets, 10 tamarins and three sakis. the main pathological findings were necrotic lesions in the lung, the intestine, and the liver. histopathologically t. gondii parasites were observed in organs from the tamarins and the marmosets but not in th ... | 1997 | 9106950 |
| fertilization-promoting peptide in reproductive tissues and semen of the male marmoset (callithrix jacchus). | fertilization-promoting peptide (fpp) is present in the prostate gland and semen of some mammals, and has been shown to enhance the fertilizing ability of both epididymal mouse and ejaculated human spermatozoa. the novel peptide may prove of importance for the treatment of some cases of male infertility, and a suitable animal model would be useful to test this hypothesis. to this end, we examined reproductive tissues and semen of the male marmoset for the presence of fpp. peptides were extracted ... | 1997 | 9110322 |
| cutaneous representations of the hand and other body parts in the cuneate nucleus of a primate, and some relationships to previously described cortical representations. | dynamic properties of primate somatosensory maps are dependent on normal central adjacencies of cutaneous representations. the cuneate nucleus is an important brainstem processing center of cutaneous information. surprisingly, there are no descriptions of functional representations of the skin in the primate cuneate nucleus; as a result, the relationships of functional representations at the brainstem level and other levels of the somatosensory neuraxis remain obscure. the present neurophysiolog ... | 1996 | 9110422 |
| oxytocin and oxytocin receptor expression in reproductive tissues of the male marmoset monkey. | using a combination of reverse transcriptase polymerase chain reaction to detect specific mrna and immunohistochemistry employing antibodies that recognize two different epitopes for each molecule, the local production of oxytocin (ot) and its cognate receptor was investigated in the male marmoset monkey (callithrix jacchus). there was synthesis of both ot and the oxytocin receptor (otr) within the testis, and both were markedly expressed within the leydig cells. a weak staining for both ot and ... | 1997 | 9116141 |
| five new or recently discovered (gbv-a) virus species are indigenous to new world monkeys and may constitute a separate genus of the flaviviridae. | in previous studies, human hepatitis viruses have been experimentally transmitted to new world monkeys of the genus saguinus (tamarins). recently, two flaviviridae-like agents (gbv-a and gbv-b) were identified in tamarins that developed hepatitis following inoculation with serum of the 11th tamarin passage of a potentially new human hepatitis agent. however, it was not shown that these viruses originated from the initial inoculum. we here report the discovery of indigenous species-specific virus ... | 1997 | 9126255 |
| hepatic hemosiderosis in common marmosets, callithrix jacchus: effect of diet on incidence and severity. | we examined the effect of dietary iron concentration on the incidence of hepatic hemosiderosis in common marmosets (callithrix jacchus) and assessed the impact of hemosiderosis on animal health. thirteen young adult common marmosets were fed nutritionally balanced natural-ingredient diets formulated to contain either 100 or 500 ppm of iron. six were fed the low-iron and seven received the high-iron diet. baseline blood values and liver iron content were determined for each animal. animals were w ... | 1997 | 9150491 |
| the expression of sf-1/ad4bp is related to the process of luteinization in the marmoset (callithrix jacchus) ovary. | expression of the nuclear receptor, steroidogenic factor-1 (sf-1/ad4bp), was studied in a primate (marmoset) ovary using immunohistochemical, rt-pcr, and immunoblot techniques. the periovulatory phase was compared with the luteal phase. with pcr we found a marmoset homolog of sf-1/ad4bp to be expressed in ovarian and other steroidogenic tissues. characteristically, the periovulatory ovaries consisted of growing (non-luteinized) small follicles together with large luteinizing follicles and many c ... | 1997 | 9151117 |
| nitric oxide synthase inhibition and mptp-induced toxicity in the common marmoset. | nitric oxide, produced following activation of n-methyl-d-aspartate (nmda) receptors, may be involved in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) toxicity since nmda receptor antagonists have been shown to prevent mptp induced nigral cell loss in primates. common marmosets were treated with either saline or mptp or l-ngnitro arginine methyl ester (l-name) or mptp and l-name. mptp-treated common marmosets showed motor deficits including bradykinesia, rigidity, and tremor accompanied by ... | 1997 | 9183819 |
| direct demonstration of persistent epstein-barr virus gene expression in peripheral blood of infected common marmosets and analysis of virus-infected tissues in vivo. | epstein-barr virus (ebv) infection in animal model systems has been studied previously in marmosets and tamarins using serology and pcr of saliva. here we directly demonstrated long-term persistence of ebv in the peripheral blood of marmosets by assaying eber rna expression. a new reverse transcription-pcr assay, able to distinguish a naturally occurring strain polymorphism in eber 2 that may be useful as a strain marker for monitoring persistence and interactions between multiple strains in the ... | 1997 | 9191939 |
| immunolocalisation of oestrogen receptor-alpha within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood. | the sites of action and the physiological role of oestrogens in the male reproductive tract are poorly understood. we have undertaken a systematic study of the immunoexpression of oestrogen receptor-alpha (er alpha) in the male rat from late fetal life through to adulthood and compared the findings with results obtained in the marmoset monkey (callithrix jacchus) from neonatal to adult life. the testes, rete testis, efferent ducts and epididymis were examined from normal male rats (aged 4, 8, 10 ... | 1997 | 9204003 |
| a local oxytocin system is part of the luteinization process in the preovulatory follicle of the marmoset monkey (callithrix jacchus). | luteinization is a complex differentiation process involving the interaction of extrinsic and intraovarian factors. the aim of this study was to examine the components of an intraovarian oxytocin (ot) system during the periovulatory period in the marmoset monkey, as well as the possible relationship of these components to other factors involved in the luteinization process, using immunohistochemistry and cell culture techniques. ovaries were collected on day 7 of the follicular phase (before the ... | 1997 | 9209075 |
| tumors of the respiratory tract observed at the german primate center, 1978-1994. | eight spontaneous pulmonary tumors (four bronchiolar tubular adenomas, two bronchiolar adenocarcinomas, two squamous-cell carcinomas) occurred in a total of 54 adult tree shrews (tupaia belangeri) of the gpc colonies between 1978 and 1994. the adenomas and adenocarcinomas consisted of tubularly or trabecularly arranged cuboidal to cylindrical cells interspersed with some pas-positive goblet cells, thus resembling the epithelial lining of respiratory bronchioles of tree shrews. the two squamous-c ... | 1996 | 9210028 |
| local relaxin biosynthesis in the ovary and uterus through the oestrous cycle and early pregnancy in the female marmoset monkey (callithrix jacchus). | the pattern of peripheral serum concentration for the peptide hormone relaxin in women points to the possibility of an interesting paracrine function in the cycle and early pregnancy. in order to investigate this physiology in detail, it was decided to examine local relaxin biosynthesis in an established primate model for human female reproductive function, the marmoset monkey (callithrix jacchus). in this initial study relaxin biosynthesis was assessed using a combination of molecular and immun ... | 1997 | 9222026 |
| the distribution of p75 neurotrophin receptor-immunoreactive cells in the forebrain of the common marmoset (callithrix jacchus). | the distribution of neurones that could be stained immunohistochemically with antibody to the p75 neurotrophin protein was studied in the forebrain of the common marmoset. the p75-immunoreactive forebrain cells appear to correspond to choline acetyltransferase-immunoreactive (i.e., cholinergic) neurones. two populations of cells could be distinguished on the basis of the intensity of p75 immunostaining. moderately stained cells correspond to cholinergic interneurones of the caudate and putamen, ... | 1997 | 9222533 |
| evidence that blue-on cells are part of the third geniculocortical pathway in primates. | colour vision in primates is mediated by cone opponent ganglion cells in the retina, whose axons project to the dorsal lateral geniculate nucleus in the visual thalamus. it has long been assumed that cone opponent ganglion cells project to the parvocellular layers of the geniculate. here, we examine the role of a third subdivision of the geniculocortical pathway: the interlaminar or koniocellular geniculate relay cells. we made extracellular recordings in the dorsal lateral geniculate nucleus of ... | 1997 | 9240412 |
| idiopathic myelofibrosis (agnogenic myeloid metaplasia) in a marmoset (callithrix jacchus): hematologic and histopathologic changes. | idiopathic myelofibrosis (imf), or agnogenic myeloid metaplasia, was diagnosed in a sexually mature male marmoset (callithrix jacchus) based on the results of hematology and histopathologic evaluation of the bone marrow. the hematologic changes included pancytopenia, leukoerythroblastosis, anisocytosis, poikilocytosis, and giant platelets. histopathologic evaluation of the bone marrow showed marked widespread fibrosis replacing hematopoietic cells and the presence of atypical megakaryocytes. in ... | 1997 | 9240843 |
| calbindin immunoreactivity delineates the circadian visual centers of the brain of the common marmoset (callithrix jacchus). | the hypothalamic suprachiasmatic nucleus and the thalamic pregeniculate nucleus (which includes the intergeniculate leaflet) comprise the circadian visual system in the primate brain. in this study, we used intraocular injections of cholera toxin subunit b to identify those nuclei in the common marmoset brain, and demonstrated that calbindin d-28k immunoreactivity apparently labels most neurons in both the suprachiasmatic and pregeniculate nuclei. these data suggest that calbindin d-28k could re ... | 1997 | 9241439 |
| spontaneous herpes simplex virus infection in common marmosets (callithrix jacchus). | 1997 | 9249183 | |
| interactions between infant growth and survival: evidence for selection on age-specific body weight in captive common marmosets (callithrix jacchus). | the objective of this study is to investigate factors influencing infant survival in captive common marmosets. we investigated the influence of age-specific weight, litter size, caging, and the presence of helpers on survival to 6 months of age in 189 callithrix jacchus infants. infant survival was analyzed using cox proportional hazards regression, and fitness functions were plotted to explore the relationship between survival and growth. results indicate that weights at birth and 120 days sign ... | 1997 | 9261508 |
| number of ovulations in the marmoset monkey (callithrix jacchus): relation to body weight, age and repeatability. | the relation between number of ovulations and body weight, age or maternal identity was examined in 69 ovarian cycles from 29 captive-born common marmoset monkeys (callithrix jacchus). specifically, we addressed the following questions: was there high repeatability of ovulation number? most of the variation in ovulation number was within, rather than between subjects. repeatability in number of ovulations was 0.081 (n = 20 females with 2-6 ovulatory cycles per female); was age related to number ... | 1997 | 9261513 |
| (-)-osu 6162 inhibits levodopa-induced dyskinesias in a monkey model of parkinson's disease. | we have studied the effects of two d2 dopamine receptor-selective compounds, (-)-osu 6162 and raclopride, on levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned common marmosets (callithrix jacchus). three monkeys developed a severe parkinsonian syndrome following administration of mptp. in response to daily levodopa treatment the animals developed reproducible and idiosyncratic peak-dose dyskinesias. pretreatment with (-)-osu 6162 and raclopride, in dose ... | 1997 | 9261828 |
| marmoset conspecific confrontation: an ethologically-based model of anxiety. | a method of measuring confrontation-induced behavioural changes in common marmosets (callithrix jacchus) together with automated monitoring of locomotor activity has been developed as a possible model of anxiety. recording both affiliative and agonistic behaviours between male/female pairs of marmosets and using diazepam as a reference drug, it has been possible to define a profile of behavioural changes which could be regarded as representing an anxiolytic response. unfamiliar male/female pairs ... | 1997 | 9264075 |
| vasopressin and oxytocin immunoreactive neurons and fibers in the forebrain of male and female common marmosets (callithrix jacchus). | vasopressin (avp) and oxytocin (ot) immunoreactive (ir) neurons and fibers were examined in the forebrain of male and female common marmosets (callithrix jacchus). as expected from previous studies of cell distribution in the rodent and primate brain, avp-ir cells were most evident in the paraventricularis, supraopticus, and suprachiasmaticus of the hypothalamus. avp-ir cells were also widely distributed in the lateral hypothalamus and the bed nucleus of the stria terminalis. a sexually dimorphi ... | 1997 | 9268061 |
| effects of click intensity and frequency on the brain-stem auditory evoked potentials in the common marmoset (callithrix jacchus). | brain-stem auditory evoked potentials (baeps) were recorded in 20 common marmosets (callithrix jacchus) to investigate the effects of click frequency up to 99 khz, in consideration of the higher hearing range of the marmoset, and intensity on wave forms and peak latencies. according to the results of baep recordings at frequencies of 4, 32, and 99 khz, the number of components recorded was affected by the stimulus intensity and the clicks at an intensity of 80 db peak equivalent sound pressure l ... | 1997 | 9271451 |
| n-methyl-d-aspartate subunit r1 involvement in the postnatal organization of the primary visual cortex of callithrix jacchus. | it has been demonstrated that the primary visual cortex is highly sensitive to manipulations of the visual environment during a specific, early, postdevelopmental period: the critical period. pharmacological studies have shown that n-methyl-d-aspartate (nmda) receptors are involved in the plasticity of the visual cortex just as they are involved in the induction of long-term potentiation (ltp), another activity-dependent form of plasticity. the setting up of synaptic connectivity in the neocorte ... | 1997 | 9295151 |
| learning impairments following injection of a selective cholinergic immunotoxin, me20.4 igg-saporin, into the basal nucleus of meynert in monkeys. | four groups of monkeys (callithrix jacchus) were injected with saline or increasing amounts of the immunotoxin, me20.4 igg-saporin, directly into the basal nucleus of meynert via a frontal trajectory which avoided damage to the overlying basal ganglia. me20.4 igg binds to the primate p75 low-affinity neurotrophin receptor, when the saporin derivitized antibody is injected into the basal forebrain, it selectively destroys the magnocellular neurons of the basal nucleus of meynert which are the cel ... | 1997 | 9300425 |
| social context affects phee call production by nonreproductive common marmosets (callithrix jacchus). | common marmosets produce two variants of their long call (phee call) in different situations. intergroup calls are produced in territorial situations, and intragroup separation calls are produced by marmosets isolated from group members. marmoset groups frequently include postpubertal, nonreproductive members; their roles in the spontaneous production of territorial vocalizations is unclear. this study analyzed the production of home cage phee calls by nonreproductive, postpubertal marmosets whi ... | 1997 | 9327096 |
| four-week repeated inhalation study of hcfc 225ca and hcfc 225cb in the common marmoset. | four male and three female marmosets in each group were exposed to air only, 1000 ppm of hcfc 225ca or 5000 ppm of hcfc 225cb, for 6 h per day for 28 consecutive days. hcfc 225ca caused a slight reduction in body weight. hcfc 225cb occasionally caused somnolence during exposure and vomiting on the first day of exposure. clinical chemistry findings included a mild reduction of triglyceride, cholesterol and phospholipid levels and increased got level in the hcfc 225ca exposure group. hcfc 225cb al ... | 1997 | 9334832 |
| proliferation and apoptosis in follicles of the marmoset monkey (callithrix jacchus) ovary. | proliferation and apoptosis were studied in ovarian follicles of immature and pubertal marmosets and in mature marmosets during the follicular, periovulatory and luteal phases. proliferation was evaluated using a ki 67 antibody and apoptosis was assessed by in situ detection of dna fragmentation. in the immature animals only small follicles were present, and the expression of ki 67 was restricted to the granulosa cells of follicles localised near the medulla. there was no evidence of dna fragmen ... | 1997 | 9341948 |
| report on primate supply for biomedical scientific work in the uk. eupren uk working party. | a working party of the uk group of european primate resources network (eupren) considered primate supply for scientific work in the uk. through a questionnaire, which achieved a very good response, it obtained details of primate use, sources and breeding in the uk and it put forward options to ensure that animal welfare is the best possible whilst ensuring continued supply. the questionnaire showed that contract research laboratories and pharmaceutical companies use about 80% of the 4233 primate ... | 1997 | 9350698 |
| relationship between expression of integrins and granulosa cell apoptosis in ovarian follicles of the marmoset (callithrix jacchus). | dna fragmentation (apoptosis) was studied during the follicular, periovulatory and luteal phase in the marmoset monkey ovary by means of terminal transferase mediated in situ nick end labeling, and correlated with immunohistochemical localization of integrins (beta 1, alpha 2 and alpha 6 subunits). for this purpose a double-labeling technique was developed. during all phases, apoptosis of granulosa cells was exclusively restricted to tertiary follicles displaying advanced stages of atresia (as m ... | 1997 | 9364802 |
| increased dopamine turnover in the putamen after mptp treatment in common marmosets. | the differences in dopamine turnover rate between the putamen and the caudate nucleus in the striatum lesioned by a neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) were studied in the common marmoset, a small new world monkey. systemic administration of mptp damaged equally and dose-dependently nigrostriatal dopaminergic neurons projecting both to the caudate nucleus and the putamen. the compensatory increase of dopamine turnover, however, occurred more prominently in the putamen ... | 1997 | 9367253 |
| vasopressin in the forebrain of common marmosets (callithrix jacchus): studies with in situ hybridization, immunocytochemistry and receptor autoradiography. | the distribution of vasopressin (avp) producing cells, their projections and avp receptors was examined in the brain of common marmosets (callithrix jacchus) using in situ hybridization, immunocytochemistry and receptor autoradiography. clusters of cells labeled for avp mrna or stained for avp immunoreactivity (avp-ir) were found in the paraventricular (pvn), supraoptic (son) and suprachiasmatic nuclei (scn) of the hypothalamus. scattered avp producing cells were also found in the lateral hypoth ... | 1997 | 9369311 |
| cell death during luteal regression in the marmoset monkey (callithrix jacchus). | the mechanism controlling luteal regression in primates is unknown but may involve cell death by apoptosis. marmoset ovaries containing corpora lutea were studied at different stages of the normal ovarian cycle. two additional groups of animals underwent induced luteolysis with either the prostaglandin f2 alpha analogue, cloprostenol, or the gnrh antagonist, antarelix, at the mid-luteal phase. apoptosis in ovarian sections was estimated both by counting the number of cells exhibiting morphologic ... | 1997 | 9370974 |
| reproductive efficiency in the common marmoset (callithrix jacchus): a longitudinal study from ovulation to birth monitored by ultrasonography. | this study examines reproductive efficiency in the common marmoset monkey, callithrix jacchus, using sequential ultrasound examinations to establish ovulation number, implantation rate, and incidence of prenatal loss. ultrasound was carried out with a 10 or 7.5 mhz probe in nonsedated animals, daily during the late follicular phase, approximately twice a week until day 20 after ovulation, and at days 35, 56, and 85 of pregnancy to enable visualization of gestation sacs, heartbeats, and fetal hea ... | 1997 | 9379480 |
| inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein. | a primary demyelinating form of experimental allergic encephalomyelitis (eae) resembling human multiple sclerosis (ms) occurs in callithrix jacchus marmosets following immunization with human white matter. participation of a t-cell immune response against myelin basic protein (mbp) in this disease model is supported by observations of increased reactivity against mbp in pbmc and of adoptive transfer of an inflammatory form of eae by mbp-reactive t-cells. to evaluate the effects of ectopic presen ... | 1997 | 9394784 |
| primate embryonic stem cells. | primate embryonic stem (es) cells are derived from preimplantation embryos, have a normal karyotype, and are capable of indefinite, undifferentiated proliferation. even after culture for more than a year, primate es cells maintain the potential to differentiate to trophoblast and derivatives of embryonic endoderm, mesoderm, and ectoderm. in this review, we compare the characteristics of es cell lines from two primate species, the rhesus monkey (macaca mulatta) and the common marmoset (callithrix ... | 1998 | 9399078 |
| entacapone enhances levodopa-induced reversal of motor disability in mptp-treated common marmosets. | oral administration of levodopa (l-dopa) (2.5-25.0 mg/kg) plus carbidopa (12.5 mg/kg p.o.) to mptp-treated common marmosets produced a dose-related increase in locomotor activity and a corresponding decrease in motor disability. pretreatment with the peripheral comt inhibitor entacapone (12.5 mg/kg p.o.) enhanced the intensity and duration of the increase in locomotor activity and the reversal of motor disability produced by a threshold dose of l-dopa (2.5 mg/kg p.o.) plus carbidopa. by contrast ... | 1997 | 9399218 |
| the common marmoset (callithrix jacchus) as a model for neuroleptic-induced acute dystonia. | to examine whether acute dystonia is induced by neuroleptic treatment, common marmosets were treated with haloperidol orally twice a week over 25 weeks until dystonic behavior was elicited. movement disorders such as acute dystonia were observed 6 weeks after the initial treatment, and had appeared in all treated animals by 25 weeks. once these movement disorders were induced, they consistently reappeared after further treatment with haloperidol, and once haloperidol dosing was discontinued, the ... | 1997 | 9408199 |
| igf-i variants which bind poorly to igf-binding proteins show more potent and prolonged hypoglycaemic action than native igf-i in pigs and marmoset monkeys. | the relative acute hypoglycaemic potencies of igf-i and several variants of igf-i which bind poorly to the igf-i binding proteins (igfbps) have been examined in marmosets (callithrix jacchus) and the pig. in the marmoset study, igf-i and des(1-3)igf-i were compared in anaesthetised and conscious animals in a range of bolus doses from 42 to 270 micrograms/kg body weight. in the pig study, igf-i was compared with four variants, des(1-3)igf-i long-igf-i, r3igf-i and long-r3igf-i (lr3igf-i), which s ... | 1997 | 9415072 |
| nonsurgical embryo transfer in the common marmoset monkey. | a technique for nonsurgical embryo transfer in common marmosets was developed. transfers were either synchronous (st) or asynchronous (at). synchronous transfers (embryo donor and the embryo recipient ovulated on the same day) were performed 5 to 8 days post-ovulation. asynchronous transfers (embryo donor had ovulated at least 2 days before the embryo recipient) were performed when the recipient was 2 to 4 days post-ovulation (donor was 6 to 8 days post-ovulation). four pregnancies from nine tra ... | 1997 | 9437262 |
| ultrasonographic and hormonal monitoring of pregnancy in the saddle back tamarin, saguinus fuscicollis. | ultrasonography was used in six saddle back tamarin females (saguinus fuscicollis) to diagnose pregnancy, monitor the patterns of uterine growth and embryonic/foetal development and examine the incidence loss of single embryos/foetuses. pregnancy was reliably diagnosed 17 days after conception, 10 days earlier than by plasma progesterone measurement. the patterns of uterine and embryonic/foetal growth paralleled those reported for the common marmoset, including a delay in embryonic development. ... | 1997 | 9438223 |
| hand preference during behavioral tests and spontaneous activity in two species of common marmoset (callithrix jacchus and callithrix penicillata). | hand preference in two adult c. jacchus (one male and one female) and five c. penicillata (three adult females and two 70-day-old male and female infants) was examined in this study. animals were housed in large wire mesh cages and daily tested twice during 40 consecutive days in 15-minute experimental sessions. tests were carried out with dog food pellets and were as follows: 1) food taking from a glass cylinder (12 cm long x 5 cm diameter), 2) food taking from an opaque plastic flask (11 cm lo ... | 1997 | 9440356 |
| stp and tip are essential for herpesvirus saimiri oncogenicity. | mutant forms of herpesvirus saimiri (hvs) subgroup c strain 488 with deletions in either stp-c488 or tip were constructed. the transforming potentials of the hvs mutants were tested in cell culture and in common marmosets. parental hvs subgroup c strain 488 immortalized common marmoset t lymphocytes in vitro to interleukin-2-independent growth, but neither of the deletion mutants produced such growth transformation. wild-type hvs produced fatal lymphoma within 19 to 20 days of experimental infec ... | 1998 | 9445031 |
| sequences of the primate epsilon-globin gene: implications for systematics of the marmosets and other new world primates. | sequences of the epsilon-globin gene were determined for five species of marmosets, along with approximately 2 kb of 5' flanking sequence. an analysis of these data, compared with those of other primates strongly supports the classification of callithrix jacchus and c. geoffroyi into the jacchus group, and c. argentata and c. mauesi into the argentata group. the pygmy marmoset, formerly identified as cebuella pygmaea joined strongly to the argentata group, indicating that without the pygmy marmo ... | 1997 | 9461380 |
| proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. | although granule cells continue to be added to the dentate gyrus of adult rats and tree shrews, this phenomenon has not been demonstrated in the dentate gyrus of adult primates. to determine whether neurons are produced in the dentate gyrus of adult primates, adult marmoset monkeys (callithrix jacchus) were injected with brdu and perfused 2 hr or 3 weeks later. brdu is a thymidine analog that is incorporated into proliferating cells during s phase. a substantial number of cells in the dentate gy ... | 1998 | 9501234 |
| effects of acute or prolonged administration of cabergoline on parkinsonism induced by mptp in common marmosets. | the effects of a single treatment or chronic administration of cabergoline (1-[(6-allylergolin-8beta-yl)carbonyl]-1-[3-(dimethylamino)p ropyl]-3-ethyl-urea), a potent, long-lasting dopamine receptor agonist, on parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in common marmosets were studied. the administration of 0.2 mg/kg or a higer dose of cabergoline began to reverse parkinsonism-like symptoms 60 min after a subcutaneous injection, and showed steady and constant ef ... | 1998 | 9512077 |
| concurrent monitoring of eeg and performance in the common marmoset: a methodological approach. | a model has been developed in a nonhuman primate, the common marmoset (callithrix jacchus), which should enable the study of long term effects of compounds with potentially psychoactive properties. the technique facilitates concurrent monitoring of both behavioral and electrophysiological parameters while animals remain in their home cages. subjects were trained to perform tests from a neuropsychological test battery (the cambridge neuropsychological test automated battery, cantab) in which they ... | 1998 | 9523903 |
| mutation of the lck-binding motif of tip enhances lymphoid cell activation by herpesvirus saimiri. | the proline-rich sh3-binding (sh3b) motif of the tyrosine kinase-interacting protein (tip) of herpesvirus saimiri (hvs) is required for binding to the cellular src family kinase lck. we constructed a mutant form of hvs in which prolines in the sh3b motif of tip were altered to alanines. this mutant form of tip was incapable of binding to lck. the mutant virus, hvs/tip msh3b, retained its ability to immortalize common marmoset lymphocytes in culture. in fact, common marmoset lymphocytes immortali ... | 1998 | 9525577 |
| a single amino acid change in the hemagglutinin protein of measles virus determines its ability to bind cd46 and reveals another receptor on marmoset b cells. | this paper provides evidence for a measles virus receptor other than cd46 on transformed marmoset and human b cells. we first showed that most tissues of marmosets are missing the scr1 domain of cd46, which is essential for the binding of edmonston measles virus, a laboratory strain that has been propagated in vero monkey kidney cells. in spite of this deletion, the common marmoset was shown to be susceptible to infections by wild-type isolates of measles virus, although they did not support edm ... | 1998 | 9525611 |
| role of androgens in follicle maturation and atresia. | androgens are products of progestogen metabolism, intermediates in oestrogen biosynthesis and local regulators of ovarian function. current understanding of intraovarian androgen formation, metabolism and action is reviewed, highlighting the contribution of androgens to the paracrine regulation of follicular maturation and atresia. any factor that alters intracellular camp levels is a potential modulator of granulosa cell differentiation, and hence follicular development. androgen appears to mod ... | 1997 | 9536210 |
| subchronic toxicity of di(2-ethylhexyl)phthalate in common marmosets: lack of hepatic peroxisome proliferation, testicular atrophy, or pancreatic acinar cell hyperplasia. | to evaluate the toxicological effect, di(2-ethylhexyl)phthalate (dehp) was administered orally at 100, 500, and 2500 mg/kg to four male and four female marmosets in each group for 13 weeks. its potentials of hepatic peroxisome proliferation, testicular atrophy, and pancreatic acinar cell hyperplasia were evaluated more closely. clofibrate, which potently causes peroxisome proliferation in rodents, was administered in like manner at 250 mg/kg as a reference drug. dehp induced significant suppress ... | 1998 | 9538047 |
| de novo administration of ropinirole and bromocriptine induces less dyskinesia than l-dopa in the mptp-treated marmoset. | in contrast to levodopa (l-dopa), de novo administration of the d2-like receptor agonist bromocriptine to patients with parkinson's disease (pd) or to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated subhuman primates is not associated with the onset of significant dyskinesia. we now compare the ability of the novel d2-like selective dopamine agonist ropinirole with that of bromocriptine and l-dopa to induce dyskinesia in mptp-treated common marmosets. mptp-treated common marmosets we ... | 1998 | 9539335 |
| lipid lowering effects of pravastatin in common marmosets. | in the present study it was examined if the common marmoset was susceptible to pravastatin (cas 81131-70-6, cs 514, mevalotin), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a (hmg-coa) reductase. it has been reported that serum lipid levels in common marmosets resemble those in humans. first serum total cholesterol and lipoprotein cholesterol levels of common marmosets were examined in comparison with those in seven different experimental animals including cynomolgus monkeys, beagle dogs, ... | 1998 | 9541726 |
| adenosine a2a antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys. | treatment of parkinson's disease with l-dopa therapy leads to long-term complications, including loss of drug efficacy and the onset of dyskinesia. adenosine a2a receptors in striatum are selectively localized to gabaergic output neurons of the striato-pallidal pathway and may avoid such problems. the novel adenosine a2a receptor antagonist kw-6002 has been examined for antiparkinsonian activity in mptp-treated primates. oral administration of kw-6002 reversed motor disability in mptp-treated co ... | 1998 | 9546333 |
| deregulation of cell growth by the k1 gene of kaposi's sarcoma-associated herpesvirus. | at a position equivalent to the gene encoding the saimiri transforming protein (stp) of herpesvirus saimiri (hvs), kaposi's sarcoma-associated herpesvirus (kshv) contains a distinct open reading frame called k1. although kshv and hvs are related members of the rhadinovirus subgroup of gamma herpesviruses, k1 and stp exhibit no similarity in amino acid sequence or in structural organization. since stp is required for the oncogenic potential of hvs, we investigated the functional consequence of k1 ... | 1998 | 9546789 |
| visuotopic organisation and neuronal response selectivity for direction of motion in visual areas of the caudal temporal lobe of the marmoset monkey (callithrix jacchus): middle temporal area, middle temporal crescent, and surrounding cortex. | on the basis of extracellular recordings in marmoset monkeys, we report on the organisation of the middle temporal area (mt) and the surrounding middle temporal crescent (mtc). area mt is approximately 5-mm long and 2-mm wide, whereas the mtc forms a crescent-shaped band of cortex 1-mm wide. neurones in area mt form a first-order representation of the contralateral hemifield, whereas those in the mtc form a second-order representation with a field discontinuity near the horizontal meridian. the ... | 1998 | 9550155 |
| changes in lymphoid tissue after treatment with a gonadotropin releasing hormone antagonist in the neonatal marmoset (callithrix jacchus). | the effect of neonatal treatment with a gonadotropin releasing hormone (gnrh) antagonist on the morphology and distribution of lymphocytes in lymphoid tissue of the infant marmoset was examined. | 1998 | 9553650 |
| substitution of ras for the herpesvirus saimiri stp oncogene in lymphocyte transformation. | stp-c488 (stp of herpesvirus saimiri [hvs] group c strain 488 [c488]) is the only virus-encoded protein found to associate with cellular ras and activate ras signal transduction pathways. to investigate an important role for ras signal transduction in stp-dependent growth transformation, we constructed recombinant strains of hvs c488 in which the stp-c488 oncogene was replaced with cellular normal ras (c-ras) or viral oncogenic ras (v-ras). recombinant hvs deltastp/v-ras immortalized primary com ... | 1998 | 9557651 |
| chronic tvp-1012 (rasagiline) dose--activity response of monoamine oxidases a and b in the brain of the common marmoset. | the stereospecific form of the known acetylenic mechanism-based mao-inhibitor agn1135 (rasagiline, tvp-1012) is devoid of sympathomimetic amphetamine-like properties. to evaluate the efficiency and selectivity of subcutaneous injections of tvp-1012 (dose range from 0.01 up to 10 mg/kg for 7 days) the activities of monoamine oxidases a and b (mao-a,-b) were determined in different brain regions of the common marmoset. at a dose of 0.1 mg/kg tvp-1012, almost 80% of mao-b activity is inhibited in a ... | 1998 | 9564627 |
| suppression of cortisol levels in subordinate female marmosets: reproductive and social contributions. | socially subordinate female common marmosets (callithrix jacchus) have markedly lower plasma cortisol levels than dominant females. subordinate females also undergo hypoestrogenemic anovulation, and estrogen can elevate glucocorticoid levels. therefore, we previously hypothesized that this cortisol difference is mediated by rank-related differences in reproductive hormones, probably estradiol. to test this possibility, we characterized the effects of the ovarian cycle and ovariectomy on plasma c ... | 1998 | 9571014 |
| receptive field dimensions of lateral geniculate cells in the common marmoset (callithrix jacchus). | we measured the spatial receptive field dimensions of cells in the lateral geniculate nucleus (lgn) of the common marmoset (callithrix jacchus) using a bipartite field stimulus in which the two halves of the field were modulated identically but in counterphase. horizontal and vertical edges between the two fields were positioned at different locations in the receptive field. by assuming that centers and surrounds have gaussian profiles, we were able to obtain a satisfactory mathematical descript ... | 1997 | 9578900 |
| estimation of gestational ages in the common marmoset (callithrix jacchus) from published prenatal growth curves. | this report compares estimated gestational ages from published cubic spline curves to gestational ages estimated retrospectively from delivery dates in 28 pregnancies from ten common marmosets (callithrix jacchus). both crl- and bpd-based estimates of gestational age were closely correlated with delivery-based gestational age estimates. of the three ultrasound machines used, the one with 16 shades of gray and a sequential linear array overestimated gestational age during early pregnancy, based o ... | 1998 | 9606040 |
| insulin-like and fibroblast growth factors and their receptors are differentially expressed in the oviducts of the common marmoset monkey (callithrix jacchus) during the ovulatory cycle. | it is suggested that growth factors support the process of maturation and differentiation in the mammalian oviduct. fibroblast growth factors (fgf) and insulin-like growth factors (igf) are possible influences on these processes. the present study describes for the first time the expression of fgf-1 and -2 and their receptors as well as igf-1 and -2 and the corresponding igf receptor type 1 in the oviduct of the new world monkey callithrix jacchus. because of the limited rna yields from oviducts ... | 1998 | 9623605 |
| functional and adaptive significance of primate pads and claws: evidence from new world anthropoids. | this study tests predicted morphoclines in fingertip morphology among four small-bodied (<1 kg) new world monkeys (saimiri sciureus, leontopithecus rosalia, callithrix jacchus, and saguinus oedipus) in order to test previous functional and adaptive explanations for the evolution of flattened nails, expanded apical pads, and grasping extremities within the order primates. small-bodied platyrrhines which frequently forage among small-diameter substrates are expected to possess 1) relatively expand ... | 1998 | 9637179 |
| tularemia in a common marmoset (callithrix jacchus) diagnosed by 16s rrna sequencing. | we report a case of tularemia in a common marmoset (callithrix jacchus) diagnosed by determination of the isolate's 16s ribosomal rna (rrna) gene sequence. pathological examination of the animal revealed a multifocal acute necrotizing hepatitis, interstitial nephritis, splenitis, and lymphangitis of the mandibular, retropharyngeal, and cervical and mesenteric lymph nodes. moreover, multiple foci of acute necrosis were found in the epithelium of the jejunum and the interstitium of the lung. bacte ... | 1998 | 9646473 |
| expression of accessory molecules and cytokines in acute eae in marmoset monkeys (callithrix jacchus). | accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (ms) and experimental autoimmune encephalomyelitis (eae) in rodent models, and are potential targets for immunotherapy. evaluation of such experimental therapies requires appropriate animal models. therefore, we analysed the expression of selected accessory molecules and cytokines in the brain of marmoset monkeys (callithrix jacchus) with acute eae, a newly described non-human primate model for ms. all ... | 1998 | 9655470 |
| a role for herpesvirus saimiri orf14 in transformation and persistent infection. | the product of open reading frame 14 (orf14) of herpesvirus saimiri (hvs) exhibits significant homology with mouse mammary tumor virus superantigen. orf14 encodes a 50-kda secreted glycoprotein, as shown previously (z. yao, e. maraskovsky, m. k. spriggs, j. i. cohen, r. j. armitage, and m. r. alderson, j. immunol. 156:3260-3266, 1996). orf14 expressed from recombinant baculovirus powerfully induces proliferation of cd4-positive cells originating from several different species. to study the role ... | 1998 | 9658125 |
| immunization of common marmosets with epstein-barr virus (ebv) envelope glycoprotein gp340: effect on viral shedding following ebv challenge. | epstein-barr virus (ebv), the cause of infectious mononucleosis, is involved in the pathogenesis of several human cancers, the highest frequency of association being found in undifferentiated nasopharyngeal carcinoma and endemic burkitt's lymphoma. the development of animal models in which potential vaccines can be tested is important. ebv infection of the common marmoset, using the m81 strain originally derived from a patient with nasopharyngeal carcinoma, induces a carrier state in this animal ... | 1998 | 9661832 |
| the distribution of calcium-binding proteins in the lateral geniculate nucleus and visual cortex of a new world monkey, the marmoset, callithrix jacchus. | antibodies directed against the calcium-binding proteins, parvalbumin and calbindin, can be used to label distinct neuronal subgroups in the primate visual pathway. we analyzed parvalbumin immunoreactivity (p-ir) and calbindin immunoreactivity (c-ir) in the lateral geniculate nucleus (lgn) and visual cortex of the marmoset, callithrix jacchus. we compared marmosets which were identified as having dichromatic or trichromatic color vision. within the lgn, the density of p-ir neurones is highest in ... | 1998 | 9682866 |
| reproduction and maintenance of two species of marmoset in captivity. | marmoset monkeys are an useful model to biological human experiments and their development in captivity has been carried out in different environment and feeding conditions. this work presents the development of callithrix jacchus jacchus and callithrix jacchus penicillata in captivity at the vivarium of the centro de biologia da reprodução. couples of marmosets, obtained with the help of the forest institute, were kept in an environment where the temperature was around 22-24 degrees c, with 10 ... | 1998 | 9697652 |
| histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis: a correlative study in the experimental autoimmune encephalomyelitis model in common marmosets (callithrix jacchus). | experimental autoimmune encephalomyelitis in the common marmoset, a nonhuman primate species (callithrix jacchus), is a new model for multiple sclerosis. given the close immunological relationship between marmosets and humans, it is an attractive model for investigating immunopathological pathways relevant to multiple sclerosis and to evaluate new treatments for the disease. unlike in the originally documented model, experimental autoimmune encephalomyelitis induced without the use of bordetella ... | 1998 | 9708823 |
| unusual case of metabolic bone disease in a common marmoset (callithrix jacchus). | metabolic bone disease was diagnosed in an 11-month-old female common marmoset (callithrix jacchus). it was depressed, reluctant to move, and was cachectic and small for its age. laboratory findings included anaemia, azotaemia and an inverse calcium to phosphorus ratio. the radiological findings showed simultaneous signs of osteomalacia and soft-tissue calcification. there was decreased bone density with lytic areas in the pelvis and femur, and severe bilateral nephrocalcinosis. postmortem exami ... | 1998 | 9717224 |
| immunoreactive riboflavin carrier protein concentration during ovulatory cycle in the common marmoset (callithrix jachhus): role of estrogen. | common marmoset, a non-human primate, is increasingly being used as a model system in reproductive endocrinology. marmosets do not menstruate but have normal cycle length of 28 +/- 2 days. the presence of protein immunologically and functionally similar to the well characterized chicken riboflavin carrier protein (crcp) has been demonstrated in circulation in pregnant marmosets. marmoset rcp (mrcp) has been partially purified and the molecular weight of the immunoreactive protein is similar to c ... | 1998 | 9717443 |
| molecular cloning in the marmoset shows that semenogelin is not the precursor of the trh-like peptide pglu-glu-pro amide. | two peptides with similar structures to thyrotropin-releasing hormone (trh), pglu-glu-pro amide and pglu-phe-pro amide, have been identified in human seminal fluid and it has been shown that one of these peptides, pglu-glu-pro amide, has the ability to increase the capacitation of sperm cells, consistent with a role in fertility. in order to select a species in which there is a high degree of expression of the genes that code for 'trh-like' peptides, we have determined the levels of these peptid ... | 1998 | 9748547 |