Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| candida glabrata prosthesis infection following pyelonephritis and septicaemia. | candida glabrata is a well-known cause of lower urinary tract infections. systemic infections caused by this organism are less common, but have increased dramatically in recent years. prosthesis infection caused by c. glabrata is extremely rare. we report a case of prosthesis failure due to c. glabrata 5 y after candidaemia and pyelonephritis caused by this organism. the same c. glabrata strain was isolated from both infections, as confirmed by the random amplified polymorphic dna (rapd) method. | 1997 | 9571751 |
| phenotypic and genotypic characterization of oral yeasts from finland and the united states. | a total of 4-22 isolates of oral yeasts per subjects from 48 yeast-positive finnish and american subjects (25 females and 23 males) were phenotyped and genotyped to determine the frequency of simultaneous oral carriage of multiple yeast taxa. an oral sample from either periodontal pockets, oral mucosa or saliva was obtained. all subjects yielded candida albicans and 3 subjects an additional yeast species (candida krusei, candida glabrata or saccharomyces cerevisiae). the api 20c aux kit distingu ... | 1997 | 9573811 |
| limitations of the current microbial identification system for identification of clinical yeast isolates. | the ability of the rapid, computerized microbial identification system (mis; microbial id, inc.) to identify a variety of clinical isolates of yeast species was compared to the abilities of a combination of tests including the yeast biochemical card (biomerieux vitek), determination of microscopic morphology on cornmeal agar with tween 80, and when necessary, conventional biochemical tests and/or the api 20c aux system (biomerieux vitek) to identify the same yeast isolates. the mis chromatograph ... | 1998 | 9574676 |
| comparison of the rapid yeast plus panel with the api20c yeast system for identification of clinically significant isolates of candida species. | the rapid yeast plus system (innovative diagnostic systems, norcross, ga.) is a qualitative micromethod employing conventional tests and single-substrate chromogenic tests and having a 4-h incubation period. this system was compared with the api20c (biomerieux vitek, hazelwood, mo.) system, a 24- to 72-h carbohydrate assimilation method. one hundred thirty-three clinical yeast isolates, including 57 of candida albicans, 26 of candida tropicalis, 23 of candida glabrata, and 27 of other yeasts, we ... | 1998 | 9574727 |
| the effect of antifungal drugs in combination on the growth of candida glabrata in solid and liquid media. | the effect of drugs in combination on the growth of candida glabrata was studied in solid medium by demonstration of reduced or enhanced growth, and in liquid medium by determination of interaction indices. amphotericin b and 5-fluorocytosine showed a synergic effect, while combinations of amphotericin b and miconazole, and miconazole and 5-fluorocytosine exhibited antagonistic effects. in addition, concentration-dependent antagonism was observed amongst combinations of metabolic inhibitors, bet ... | 1998 | 9578162 |
| nosocomial breakthrough fungaemia during antifungal prophylaxis or empirical antifungal therapy in 41 cancer patients receiving antineoplastic chemotherapy: analysis of aetiology risk factors and outcome. | forty-one episodes of breakthrough fungaemia occurring over a 7.5 year period in the national and st elizabeth's cancer institutes in bratislava, slovakia, were analysed. five of them occurred during prophylaxis with fluconazole (one torulopsis glabrata, one hansenula anomala, two candida krusei and one candida parapsilosis), ten with itraconazole (three trichosporon pullulans, one trichosporon beigelii, one cryptococcus laurentii, three candida albicans and two t. glabrata), 11 during prophylax ... | 1998 | 9578164 |
| in vitro activities of terbinafine against cutaneous isolates of candida albicans and other pathogenic yeasts. | terbinafine is active in vitro against a wide range of pathogenic fungi, including dermatophytes, molds, dimorphic fungi, and some yeasts, but earlier studies indicated that the drug had little activity against candida albicans. in contrast, clinical studies have shown topical and oral terbinafine to be active in cutaneous candidiasis and candida nail infections. in order to define the anti-candida activity of terbinafine, we tested the drug against 350 fresh clinical isolates and additional str ... | 1998 | 9593126 |
| influence of test conditions on antifungal time-kill curve results: proposal for standardized methods. | this study was designed to examine the effects of antifungal carryover, agitation, and starting inoculum on the results of time-kill tests conducted with various candida species. two isolates each of candida albicans, candida tropicalis, and candida glabrata were utilized. test antifungal agents included fluconazole, amphotericin b, and ly303366. time-kill tests were conducted in rpmi 1640 medium buffered with morpholinepropanesulfonic acid (mops) to a ph of 7.0 and incubated at 35 degrees c. pr ... | 1998 | 9593151 |
| candidemia: a nosocomial complication in adults with late-stage aids. | we retrospectively analyzed 13 episodes of candidemia observed between july 1990 and july 1995 in human immunodeficiency virus (hiv)-infected adults. candidemia was nosocomially acquired by 11 patients, among whom nine had a central venous catheter (cvc). twelve cases were of stage c2/c3 according to the 1993 classification of the centers for disease control and prevention. the median cd4+ cell count was 10/mm3 (range, 3-400/mm3). causative species were candida albicans in nine episodes and cand ... | 1998 | 9597242 |
| in vitro activity of voriconazole against candida species. | the in vitro activity of voriconazole was compared with that of itraconazole and fluconazole against 181 isolates of candida albicans, 124 isolates of candida glabrata, and 20 isolates of candida krusei obtained from the early 1980s through the mid-1990s. voriconazole had greater intrinsic activity than fluconazole or itraconazole against all three candida species. for c. glabrata, c. krusei, and c. albicans, the mic50 values for voriconazole were 1 microgram/ml, 0.5 microgram/ml, and 0.01 micro ... | 1998 | 9597390 |
| a high-copy-number ade2-bearing plasmid for transformation of candida glabrata. | the candida glabrata ade2 gene encoding aminoimidazole ribonucleotide (air) carboxylase (ec 4.1.1.21) was isolated by complementation of the ade2-1 mutation in saccharomyces cerevisiae. the predicted amino acid (aa) sequence is 75% identical to that of s. cerevisiae. integrative transformation was used to produce a c. glabrata strain bearing a deletion of ade2 coding sequences. a high-copy-number shuttle vector bearing the ade2 gene was constructed and contains a fragment of s. cerevisiae mitoch ... | 1998 | 9602176 |
| [vulvovaginal mycoses]. | due to its pathogenety candida albicans is the most frequent yeast in cases of vaginal candidosis, probably mostly caused by local immunological weakness. in 5-30% one can expect a vaginal yeast colonisation depending on age, estrogen influence, pregnancy and dispositions by illness. prepartal vaginal yeast colonisation should be treated to protect the newborn. the only typical symptom of acute vaginal candidosis is itching. beside history and clinical symptoms, examination of vaginal secretion ... | 1998 | 9606884 |
| evaluation of endpoints for antifungal susceptibility determinations with ly303366. | we have previously reported poor correlation between the in vitro fungicidal activity of ly303366 and mic results in rpmi medium based upon the manufacturer's suggested susceptibility endpoint, lack of visual growth. additionally, we have noted a significant trailing effect with ly303366 when mics are determined in rpmi medium. these observations have led us to evaluate an alternative susceptibility endpoint for ly303366, an 80% reduction in growth compared with control (similar to that utilized ... | 1998 | 9624481 |
| a role for hem2 in cadmium tolerance. | a candida glabrata cadmium-sensitive mutant partially defective in glutathione production and exhibiting a complete absence of phytochelatins was used to clone a gene required for cd tolerance. transformation of the cd-sensitive mutant with a genomic library from the wild-type c. glabrata led to the cloning of a gene that restored cd tolerance and formation of cd-glutathione and cd-phytochelatin complexes. the cloned gene showed high levels of nucleic acid and protein sequence homology to the he ... | 1998 | 9654753 |
| fulminant hepatitis complicated by small intestine infection and massive hemorrhage. | a 34-year-old man diagnosed with fulminant hepatitis, caused by hepatitis b virus, and acute renal failure was referred to our hospital. after admission to the intensive care unit, the liver and renal failure were ameliorated. melena requiring transfusion occurred during the course of his illness. endoscopic examination demonstrated pseudomembranes, erosions, ulcers, and hemorrhage in the duodenum, the upper jejunum, and the terminal ileum, suggesting widespread lesions throughout the small inte ... | 1998 | 9658323 |
| fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, pdh1, in candida glabrata. | sequential candida glabrata isolates were obtained from the mouth of a patient infected with human immunodeficiency virus type 1 who was receiving high doses of fluconazole for oropharyngeal thrush. fluconazole-susceptible colonies were replaced by resistant colonies that exhibited both increased fluconazole efflux and increased transcripts of a gene which codes for a protein with 72.5% identity to pdr5p, an abc multidrug transporter in saccharomyces cerevisiae. the deduced protein had a molecul ... | 1998 | 9661006 |
| solution structure of a zinc domain conserved in yeast copper-regulated transcription factors. | the three dimensional structure of the n-terminal domain (residues 1-42) of the copper-responsive transcription factor amtl from candida glabrata has been determined by two-dimensional 1h-correlated nuclear magnetic resonance (nmr) methods. the domain contains an array of zinc-binding residues (cys-x2-cys-x8-cys-x-his) that is conserved among a family of cu-responsive transcription factors. the structure is unlike those of previously characterized zinc finger motifs, and consists of a three-stra ... | 1998 | 9665167 |
| post-mortem findings in patients with repeatedly mycological demonstration of candida glabrata. | in our mycological laboratory we saw an increase in the occurrence of candida glabrata isolates from 0.5% in 1990 to 22.2% in 1996, mainly isolates of high-risk patients of the intensive care unit and the oncological ward. we were interested to analyse whether this increase in c. glabrata was also demonstrable in a corresponding number of deep-seated candidosis. eighteen patients were autopsied and examined microscopically. in all patients, repeated occurrence of c. glabrata, with or without c. ... | 1998 | 9670764 |
| [isolation, identification, and typing of yeasts from hiv-positive patients with oral candidiasis]. | a study of oral candidiasis was conducted among 25 hiv-positive and aids patients. the predominant clinical form of presentation was the pseudomembranous one, whereas the most frequently yeast species found in the isolations were: candida albicans (54.1%), candida tropicalis (8.1%), and torulopsis glabrata (8.1%). it was demonstrated that patients with recurrent infections have colonization of the oral cavity by multiple strains and/or yeast species more often (30.8%) than those through their fi ... | 1997 | 9685984 |
| hemoglobin differentially induces binding of candida, trichosporon, and saccharomyces species to fibronectin. | fibronectin (fn) is an abundant host protein that is specifically recognized by several pathogenic yeasts. binding of fn in solution to candida, trichosporon, and saccharomyces species is increased 20- to 110-fold by growth in medium containing hemoglobin, but specific adhesion to immobilized fn is increased only in candida albicans, candida tropicalis, candida krusei, and candida glabrata. hemoglobin induces both specific and nonspecific binding of soluble fn. nonspecific binding accounts for a ... | 1998 | 9697732 |
| evaluation of the etest method for determining fluconazole susceptibilities of 402 clinical yeast isolates by using three different agar media. | the performance of the etest for fluconazole susceptibility testing of 402 yeast isolates was assessed against the national committee for clinical laboratory standards (nccls) microdilution broth method. the nccls method employed rpmi 1640 broth medium, and mics were read after incubation for 48 h at 35 degrees c. etest mics were determined with rpmi agar containing 2% glucose (rpg), casitone agar (cas), and mueller-hinton agar (mha) and were read after incubation for 48 h at 35 degrees c. the y ... | 1998 | 9705397 |
| yeasts in the gastrointestinal tract of preweaned calves and possible involvement of candida glabrata in neonatal calf diarrhea. | to examine the possibility of a mycotic involvement in neonatal calf diarrhea (ncd) the presence of fungi was assessed in (a) the intestinal contents of dead calves and fecal samples submitted for routine laboratory examination, (b) fecal specimens, sampled once in winter and once in summer, of calves raised on 2 farms with different management systems, and (c) mucosal scrapings of various segments of the digestive tract of a diarrheic calf, massively shedding candida glabrata. c. glabrata was t ... | 1998 | 9725026 |
| sordarins: a new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts. | gr135402, a sordarin derivative, was isolated in an antifungal screening program. gr135402, sordarin, and derivatives of both compounds were evaluated for their ability to inhibit cell-free translational systems from five different pathogenic fungi (candida albicans, candida glabrata, candida krusei, candida parapsilosis, and cryptococcus neoformans). the activity profile of gr135402 is extended to other chemical compounds derived from sordarin. experimental results indicate that sordarin analog ... | 1998 | 9736548 |
| susceptibilities of candida species isolated from the lower gastrointestinal tracts of high-risk patients to the new semisynthetic echinocandin ly303366 and other antifungal agents. | fifty-two percent of stool specimens collected from 1,200 high-risk patients were colonized with yeasts, primarily candida albicans (53. 6%) and candida glabrata (35.7%). susceptibilities to all antifungal agents tested, including ly303366, were similar to those reported previously for candida species isolated from blood. | 1998 | 9736582 |
| voriconazole against fluconazole-susceptible and resistant candida isolates: in-vitro efficacy compared with that of itraconazole and ketoconazole. | we compared the in-vitro activity of fluconazole, itraconazole, ketoconazole and voriconazole against 67 blood isolates of candida spp. exhibiting a wide range of fluconazole mics (0.125 to >64 mg/l). voriconazole was the most potent in vitro, followed by itraconazole, ketoconazole and fluconazole. itraconazole and voriconazole had in-vitro activity against fluconazole-susceptible and -resistant candida isolates. higher itraconazole and voriconazole mics were observed in isolates exhibiting high ... | 1998 | 9738846 |
| practical guide to diagnosing and treating vaginitis. | bacterial vaginosis (bv), candidiasis, and trichomoniasis account for more than 90% of vaginal infections. bv typically is associated with a decrease in commensal, protective lactobacilli and a proliferation of other flora. mobiluncus is pathognomonic but found in only 20% of cases. presence of 3 of 4 criteria indicates bv: a homogenous noninflammatory discharge (not many wbcs); ph >4.5; clue cells (bacteria attached to borders of epithelial cells, > 20 % of epithelial cells); and a positive whi ... | 1997 | 9746676 |
| isolation of candida glabrata homologs of the saccharomyces cerevisiae kre9 and knh1 genes and their involvement in cell wall beta-1,6-glucan synthesis. | the candida glabrata kre9 (cgkre9) and knh1 (cgknh1) genes have been isolated as multicopy suppressors of the tetracycline-sensitive growth of a saccharomyces cerevisiae mutant with the disrupted knh1 locus and the kre9 gene placed under the control of a tetracycline-responsive promoter. although a cgknh1delta mutant showed no phenotype beyond slightly increased sensitivity to the k1 killer toxin, disruption of cgkre9 resulted in several phenotypes similar to those of the s. cerevisiae kre9delta ... | 1998 | 9748432 |
| oral microbiota and implant type membranes. | candida albicans (ca), staphylococcus aureus (sa), streptococcus sanguis (ss), actinomyces naeslundii (an), actinomyces odontolyticus (ao), porphyromona spp (p spp), candida glabrata (cg), candida krusei (ck), and rhodotorula spp (r spp) were tested with equal pieces of biodegradable membranes. membranes pretreated with saliva or clorhexidine and nontreated control membranes were tested in three different culture media containing 0.1 ml homologous suspension for each strain under study. incubati ... | 1998 | 9759038 |
| vulvovaginal candidiasis in female sex workers. | vulvovaginal candidiasis is a frequent inflammatory process in women but it has not been widely studied in female sex workers (fsws). to estimate the frequency of candida species infection in fsws and to identify related risk factors and clinical findings, we carried out a retrospective study of 1923 fsws over 11 years. we also performed a prospective study of 163 consecutive fsws with a history of candidiasis during a 4-year period. candida species were isolated in 1967 samples (18.5% of the to ... | 1998 | 9764936 |
| antimicrobial activity of ambisome and non-liposomal amphotericin b following uptake of candida glabrata by murine epidermal langerhans cells. | the antifungal efficacy and cellular toxicity of ambisome(r) and non-liposomal amphotericin b were compared in cultured epidermal langerhans cells infected with candida glabrata. uptake of the yeast was determined by light and electron microscopy, and viability was assessed by plating dilutions of lysates from yeast-infected langerhans cells and counting colony forming units. the candida-infected langerhans cells were incubated for 6, 24 or 48 h with 12.5 micro ml-1 of ambisome or non-liposomal ... | 1998 | 9776826 |
| a controllable gene-expression system for the pathogenic fungus candida glabrata. | a system for controlling gene expression was established in the pathogenic fungus candida glabrata to elucidate the physiological functions of genes. to control the expression of the gene of interest, the c. glabrata cells were first transformed with the plasmid carrying the tetracycline repressor-transactivator fusion tetr::gal4, then with the dna fragment containing the controllable cassette, the tetracycline operator chimeric promoter (teto::schop1). the peptide elongation factor 3 (cgtef3) a ... | 1998 | 9782488 |
| sordarins: in vitro activities of new antifungal derivatives against pathogenic yeasts, pneumocystis carinii, and filamentous fungi. | gm 193663, gm 211676, gm 222712, and gm 237354 are new semisynthetic derivatives of the sordarin class. the in vitro antifungal activities of gm 193663, gm 211676, gm 222712, and gm 237354 against 111 clinical yeast isolates of candida albicans, candida kefyr, candida glabrata, candida parapsilosis, candida krusei, and cryptococcus neoformans were compared. the in vitro activities of some of these compounds against pneumocystis carinii, 20 isolates each of aspergillus fumigatus and aspergillus f ... | 1998 | 9797217 |
| in vitro activity of a new polyene, spa-s-843, against yeasts. | the in vitro activity of a new water-soluble polyene, spa-s-843, was evaluated against 116 strains of candida, cryptococcus, and saccharomyces spp. and compared with that of amphotericin b. spa-s-843 demonstrated better inhibitory activity against all of the yeasts examined and better fungicidal activity against candida albicans, candida glabrata, candida krusei, and candida tropicalis than did amphotericin b. | 1998 | 9797244 |
| candida glabrata endophthalmitis following penetrating keratoplasty. | 1998 | 9797681 | |
| constant low rate of fungemia in norway, 1991 to 1996. the norwegian yeast study group. | since 1991 information on yeast isolates from blood cultures has been recorded prospectively from all microbiological laboratories (5 university and 16 county or local hospital laboratories) in norway (population, 4.3 million). from 1991 to 1996 a total of 571 episodes of fungemia in 552 patients occurred (1991, 109 episodes; 1992, 81 episodes; 1993, 93 episodes; 1994, 89 episodes; 1995, 98 episodes; and 1996, 101 episodes). the fungemia rates per 10,000 patient days were 0.29 in 1991 and 0.27 i ... | 1998 | 9817853 |
| comparison of a new commercial colorimetric microdilution method with a standard method for in-vitro susceptibility testing of candida spp. and cryptococcus neoformans. | the sensititre yeast one method (accumed international ltd, east grinstead, uk) is a microplate-based procedure that incorporates an oxidation-reduction indicator, alamar blue, for the in-vitro testing of five antifungal agents (amphotericin b, fluconazole, itraconazole, ketoconazole and flucytosine). we compared this colorimetric method with a standard broth microdilution test, performed according to us national committee for clinical laboratory standards document m27-a guidelines, for determin ... | 1998 | 9818741 |
| rapid identification of candida glabrata by using a dipstick to detect trehalase-generated glucose. | candida glabrata is a yeast frequently isolated from human specimens. based upon its well-known ability to rapidly hydrolyze trehalose, we have developed a novel and cost-effective test incubating one yeast colony emulsified in 50 microl of citrate buffer (0.1 m [ph 5. 0]) containing 4% (wt/vol) trehalose for 3 h at 37 degrees c. trehalase-generated glucose is detected with a commercially available dipstick (range, 1.0 to 50 g/liter). for evaluation, consecutive clinical isolates and several ref ... | 1999 | 9854091 |
| persistent oral candidosis by non-albicans candida strains including candida glabrata in a human immunodeficiency virus-infected patient observed over a period of 6 years. | a 38-year-old woman infected with human immunodeficiency virus (hiv) presented with persistent oral candidosis in which non-albicans candida strains were the predominant yeasts in most of the examinations performed over a period of 6 years. oral treatment with fluconazole had no effect on clinical signs of oral candidosis. in 8 of a total of 11 specimens, candida glabrata, candida parapsilosis and candida tropicalis were at least suspected as the causative pathogens of oral candidosis. the non-r ... | 1998 | 9861840 |
| candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to c. albicans. | until recently, candida glabrata was considered a relatively nonpathogenic commensal fungal organism of human mucosal tissues. however, with the increased use of immunosuppressive agents, mucosal and systemic infections caused by c. glabrata have increased significantly, especially in the human immunodeficiency virus-infected population. a major obstacle in c. glabrata infections is their innate resistance to azole antimycotic therapy, which is very effective in treating infections caused by oth ... | 1999 | 9880475 |
| evaluation of chromagar candida for presumptive identification of clinically important candida species. | chromagar candida is a recently described and differential medium for the isolation and the presumptive identification of clinically important yeasts. we evaluated it with 262 yeast strains from clinical specimens, including 173 candida albicans, 21 candida tropicalis, 8 candida krusei, 49 candida glabrata, and 12 strains of other yeast species. strains were presumptively identified on the basis of colony color and texture. these observations were compared with conventional identification result ... | 1998 | 9884836 |
| antifungal susceptibility of candida isolates at the american university of beirut medical center. | for the first time from lebanon, the antifungal susceptibility patterns of 70 consecutive clinical candida isolates (each from one patient) representing 48 c. albicans, 12 c. tropicalis, 6 c. parapsilosis, 2 c. kruseii, and 2 c. (torulopsis) glabrata were studied against amphotericin b (ap), 5-fluorocytosine (fc), ketoconazole (ke), fluconazole (fl), and itraconazole (it) using the epsilometer test (e-test; ab biodisk, solna, sweden). the mic90 (and mic range, mg/l) determined, at 24 h incubatio ... | 1998 | 9916903 |
| advances in molecular genetics of candida albicans and candida glabrata. | ten years ago, when molecular genetic methods were being applied vigorously to viruses, bacterial pathogens and eukaryotic parasites, there seemed to be a partial paralysis in applying them to infectious fungi; this state of affairs was more than apparent in the composition of the symposia at the isham conference in 1987. since then, however, things have changed. the isham conference held in italy in 1997 was replete with studies utilizing molecular genetic techniques to answer questions related ... | 1998 | 9988512 |
| images in haematology. candida glabrata in a blood film. | 1999 | 10027704 | |
| be-31405, a new antifungal antibiotic produced by penicillium minioluteum. i. description of producing organism, fermentation, isolation, physico-chemical and biological properties. | a new antifungal antibiotic, be-31405, was isolated from the culture broth of a fungal strain, penicillium minioluteum f31405. be-31405 was isolated by adsorption on high porous polymer resin (diaion hp-20), followed by solvent extraction, precipitation and crystallization. be-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as candida albicans, candida glabrata and cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as p ... | 1998 | 10048566 |
| amphotericin b- and fluconazole-resistant candida spp., aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides. | the present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, pgla, are active against amphotericin b-resistant candida albicans, candida krusei, and aspergillus fumigatus strains and against a fluconazole-resistant candida glabrata isolate. | 1999 | 10049295 |
| efficient homologous and illegitimate recombination in the opportunistic yeast pathogen candida glabrata. | the opportunistic pathogen candida glabrata causes significant disease in humans. to develop genetic tools to investigate the pathogenicity of this organism, we have constructed ura3 and his3 auxotrophic strains by deleting the relevant coding regions in a c. glabrata clinical isolate. linearized plasmids carrying a saccharomyces cerevisiae ura3 gene efficiently transformed the ura3 auxotroph to prototrophy. homologous recombination events were observed when the linearized plasmid carried short ... | 1999 | 10049916 |
| torulopsis glabrata an emerging yeast pathogen in cancer patients. | 1999 | 10075271 | |
| vulvovaginitis due to candida glabrata. an emerging problem. | a review is presented of the emerging problem of resistant and chronic vaginitis due to candida glabrata. although accurate numbers are lacking, several investigators report encountering increased numbers of women with vaginitis due to c. glabrata. possible reasons for this apparent increase are discussed. risk factors and clinical manifestations of symptomatic c. glabrata vaginitis differ from those of c. albicans, c. glabrata being less susceptible to fungistatic azole agents is more difficult ... | 1998 | 10085680 |
| [comparison of strain specificity of yeasts from various organs of women with vaginal candidiasis]. | sexual partners harbour often identical yeast strains in the vagina, orointestinal tract and sperm in cases of recurrent vulvovaginal candidoses. mycologic cultures from the vagina, mouth and stool of the patient and from the mouth and sperm of her partner were cultured on sabouraud-glucose-agar and, if positive, specified by candida id-agar (biomerieux), rice agar and the system walk away (dade). equal species were compared by dnr-fingerprinting using pcr. the vagina of 22 women was in 21 cases ... | 1998 | 10085681 |
| in vitro pharmacodynamic properties of mk-0991 determined by time-kill methods. | mk-0991 has demonstrated activity against a variety of fungal pathogens. we evaluated the mic endpoint for mk-0991 by reading the endpoint using three methods and comparing these results with minimum fungicidal concentrations and electron micrographs. the concentration that resulted in 80% inhibition of fungal growth compared with control, similar to the endpoint for the azole antifungal agents, provided the most consistent results. additionally, we investigated the time-kill properties of this ... | 1999 | 10091029 |
| molecular typing of candida spp. by random amplification of polymorphic dna and analysis of restriction fragment length polymorphism of ribosomal dna repeats. | random amplification of polymorphic dna (rapd) using an arbitrary oligonucleotide primer (5'-cggtgcgacg) and analysis of restriction fragment length polymorphism of ribosomal dna (rdna-rflp) after digestion of genomic dna with restriction endonuclease ecori were investigated as tools for genotypic delineation beyond the species level of 91 candida clinical isolates and four reference strains including 33 candida albicans, 19 candida tropicalis, 22 candida krusei and 21 candida (torulopsis) glabr ... | 1999 | 10190116 |
| [epidemiology of yeast colonization and oropharyngeal infection other than candida albicans in patients with hiv infection]. | an increasing frequency of opportunistic fungal infections in immunosuppressed patients in recent years. concurrent with this finding, it has been noted an increasing use of fluconazole. in addition, non-candida albicans species (ncas), most of which are fluconazole-resistant have been increasing isolated. the aim of this study was to investigate the epidemiology of colonization and infection due to ncas in hiv-infected patients. | 1999 | 10191483 |
| susceptibility of candida species isolated from female prostitutes with vulvovaginitis to antifungal agents and boric acid. | the aim of this study was to determine the antifungal susceptibility of 108 candida albicans and 23 candida glabrata isolates obtained from female prostitutes with vulvovaginitis, a population for which available data is limited. amphotericin b, flucytosine, and fluconazole were tested by broth microdilution, and boric acid was tested by the agar dilution method. the susceptibility patterns found in this population were the same as those in the general population. candida glabrata required great ... | 1999 | 10192716 |
| antifungal activity of chlorhexidine containing mouthrinses. an in vitro study. | oral candidosis has emerged as an increasing problem in immunocompromised patients because oral cavity represents an important port of entry for systemic fungal infections. | 1998 | 10207302 |
| evaluation of dna-based typing procedures for strain categorization of candida spp. | dna-based procedures have replaced earlier epidemiologic methodologies that relied on nonreproducible and insensitive measurements of phenotypic characteristics to identify a specific strain as the source of infection. the reliability (interlaboratory percent agreement for strain delineation) and sensitivity (recognition of subtle strain-to-strain variation) of similar dna-based typing systems by different laboratories were evaluated. ten isolates (five epidemiologic-related and five unrelated s ... | 1999 | 10212749 |
| [the in vitro properties of a new hydroxypyridone antimycotic rilopirox, with special reference to its anti-candida activity]. | in vitro properties of a new hydroxypyridone antimycotic rilopirox (ril) with special reference to its anti-candida activities were studied in comparison with the three reference drugs, ciclopirox olamine (cpo), oxiconazole nitrate (ocz) and isoconazole nitrate (icz), using several strains of candida albicans and candida glabrata as the test organisms. ril was potently fungicidal for growing cultures of these candida strains, whereas all the three reference drugs were slightly fungicidal or fung ... | 1999 | 10221179 |
| in vitro susceptibilities of clinical yeast isolates to the new antifungal eberconazole compared with their susceptibilities to clotrimazole and ketoconazole. | the antifungal activity of eberconazole, a new imidazole derivative, against 124 clinical isolates of candida comprising eight different species and to 34 isolates of cryptococcus neoformans was compared to those of clotrimazole and ketoconazole. mics of eberconazole, determined by the national committee for clinical laboratory standards standardized microbroth method, were equal to or lower than those of other azoles, especially for candida krusei and candida glabrata, which are usually resista ... | 1999 | 10223946 |
| natural defenses against candida colonization breakdown in the oral cavities of the elderly. | candida colonization of the oral cavity increases in the elderly. a major predisposing condition is denture use, which also increases in the elderly. to test whether the increase in colonization is age-related in a fashion independent of denture use, we analyzed the frequency (incidence) of carriage, the intensity of carriage, the multiplicity of species, and the genetic relatedness of strains in the oral cavities of 93 test subjects separated into the three age groups: 60 to 69 yr, 70 to 79 yr, ... | 1999 | 10326730 |
| rapid speciation of the five most medically relevant candida species using pcr amplification and a microtiter plate-based detection system. | background: diagnosis of disseminated candidiasis can be difficult, as patient symptoms are often vague and blood cultures negative despite systemic involvement. rapid detection of candida would be advantageous, as delays in initiating antifungal therapy increase mortality. conventional blood culturing methods require at least 3-7 days for detecting and speciating isolates, especially non-albicans species. in contrast, dna amplification techniques make it possible to detect candida dna directly ... | 1996 | 10330197 |
| a comparative evaluation of etest and broth microdilution methods for fluconazole and itraconazole susceptibility testing of candida spp. | the etest strip is a promising tool of broad application in clinical microbiology. the method provides mic readings and is easier to perform than broth microdilution. we carried out a study to compare the mics of fluconazole and itraconazole obtained by the etest with those obtained by broth microdilution, performed according to the guidelines of the nccls document m27-a, with 402 clinical isolates (360 candida albicans, 17 candida tropicalis, nine candida krusei, nine candida glabrata and seven ... | 1999 | 10350375 |
| electrophoretic karyotyping and triazole susceptibility of candida glabrata clinical isolates. | a series of 35 strains of candida glabrata isolated from 29 subjects (5 aids patients and 24 hiv-seronegative individuals) were typed by electrophoretic karyotyping and tested for their susceptibilities to both fluconazole and itraconazole. almost every individual harboured his/her own specific isolate (dna type). neither the source of isolation nor the patient's hiv status was associated with a given dna type. recurrences were generally due to the persistence of the same dna type over time. onl ... | 1999 | 10357051 |
| evaluation of six commercial tests and the germ-tube test for presumptive identification of candida albicans. | six commercial tests (albicans id, biomérieux, france; candiselect, sanofi diagnostics pasteur, france; chromagar candida, becton dickinson, usa; fluoroplate candida, merck, germany; fongiscreen 4h, sanofi diagnostics pasteur; and murex candida albicans, murex diagnostics, usa) and the germ-tube test for presumptive identification of candida albicans were evaluated using clinical isolates of candida albicans (n = 350) and of non-albicans yeasts (n = 135). sensitivities and specificities of all t ... | 1999 | 10357052 |
| increased adherence of fluconazole-resistant isolates of candida species to explanted esophageal mucosa. | the adherence of fluconazole-resistant and fluconazole-susceptible isolates of candida albicans to explanted rabbit esophageal mucosa was examined in vivo. among six candida albicans isolates collected from hiv-infected patients, three fluconazole-resistant (mic > 64 microg/ml) isolates attached more avidly than three fluconazole-susceptible strains (mic < or = 0.5 microg/ml) to esophageal mucosa (p < or = 0.05). when three strains each of six different candida spp. were compared, the more inher ... | 1999 | 10357058 |
| evaluation of mycology laboratory proficiency testing. | changes over the last decade in overt proficiency testing (opt) regulations have been ostensibly directed at improving laboratory performance on patient samples. however, the overt (unblinded) format of the tests and regulatory penalties associated with incorrect values allow and encourage laboratorians to take extra precautions with opt analytes. as a result opt may measure optimal laboratory performance instead of the intended target of typical performance attained during routine patient testi ... | 1999 | 10364601 |
| differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in candida albicans. | the anti-candida potentials of 12 korean medicinal plants were explored: methanol extracts from coptis rhizoma and phellodendron amurense caused significant inhibition of growth of candida albicans, candida glabrata, candida krusei and candida parapsilosis. the predominant active components of the extracts were the protoberberines berberine and palmatine; the most potent inhibition of growth was exhibited by berberine on c. krusei (mic <4 mg/l) and palmatine on c. parapsilosis (mic 16 mg/l). bot ... | 1999 | 10382888 |
| purification, reconstitution, and inhibition of cytochrome p-450 sterol delta22-desaturase from the pathogenic fungus candida glabrata. | sterol delta22-desaturase has been purified from a strain of candida glabrata with a disruption in the gene encoding sterol 14alpha-demethylase (cytochrome p-45051; cyp51). the purified cytochrome p-450 exhibited sterol delta22-desaturase activity in a reconstituted system with nadph-cytochrome p-450 reductase in dilaurylphosphatidylcholine, with the enzyme kinetic studies revealing a km for ergosta-5,7-dienol of 12.5 microm and a vmax of 0. 59 nmol of this substrate metabolized/min/nmol of p-45 ... | 1999 | 10390230 |
| lack of sialidase activity in candida albicans and candida glabrata. | because several micro-organisms having close contact to animal hosts and man produce sialidase (ec 3.2.1.18) as a tool for adhesion and invasion, we investigated two candida species for the presence of this enzyme. two sensitive assays, a fluorometric test with 4-methylumbelliferyl-alpha-d-n-acetylneuraminic acid and a radiometric test with 3h-labelled sialyllactitol as sialidase substrates, were applied to detect sialidase activity. none of 40 candida albicans and 10 c. glabrata strains grown i ... | 1999 | 10394845 |
| in vitro activity of rilopirox against fluconazole-susceptible and fluconazole-resistant candida isolates from patients with hiv infection. | the in vitro antifungal activity of the new hydroxypyridone antimycotic rilopirox has been evaluated against 38 fluconazole-susceptible and -resistant clinical isolates of candida albicans together with other candida species isolated from patients with human immunodeficiency virus (hiv) infection and oropharyngeal candidosis. minimum inhibitory concentrations (mics) of both rilopirox and fluconazole were measured by a microdilution method using high-resolution medium supplemented with asparagine ... | 1999 | 10394849 |
| evaluation of chromagar candida for rapid screening of clinical specimens for candida species. | chromagar candida is a new differential culture medium that allows selective isolation of yeasts and simultaneously identifies colonies of candida albicans, candida glabrata, candida tropicalis and candida krusei. we evaluated this medium and compared it with a reference medium, sabouraud glucose agar, for the presumptive identification of yeast species isolated directly on the medium from 1150 clinical specimens. a total of 731 specimens showed no growth, 299 isolates (70.2%) showed growth to t ... | 1999 | 10394850 |
| cloning of a centromere binding factor 3d (cbf3d) gene from candida glabrata. | the gene encoding centromere binding factor 3d (cbf3d) of the human pathogenic yeast candida glabrata has been isolated by hybridization of saccharomyces cerevisiae cbf3d (sccbf3d) dna to a c. glabrata partial genomic library. sequence analysis revealed a 540 bp open reading frame encoding a protein of 179 amino acids with a calculated molecular mass of 20.9 kda. the amino acid sequence is highly homologous (78.6% identity) to sccbf3d and 48.3% identical to the human homologue p19 (skp1). southe ... | 1999 | 10398347 |
| in-vitro resistance to azoles associated with mitochondrial dna deficiency in candida glabrata. | a commercially available disk diffusion procedure was used in a large-scale study to evaluate the susceptibility of a wide range of candida isolates to polyenes and azoles. with almost all isolates of c. glabrata resistant colonies were present within the inhibition zones for the azole compounds fluconazole, ketoconazole and miconazole, and less frequently for isoconazole, econazole and clotrimazole. ten randomly selected isolates were cloned by limiting dilution and the susceptibility of the re ... | 1999 | 10403417 |
| 5-fluorocytosine antagonizes the action of sterol biosynthesis inhibitors in candida glabrata. | the concentration-dependent antagonistic interaction between 5-fluorocytosine and a sterol biosynthesis inhibitor (sbi) was studied using intact cells and cell-free extracts of candida glabrata. 5-fluorocytosine promoted incorporation of radioactivity into 4-desmethylsterols (p < 0.01), and enhanced the relative and absolute increases of ergosterol (p < 0.05) in c. glabrata incubated aerobically with an sbi (miconazole or amorolfine). further aerobic incubation of c. glabrata with combinations o ... | 1999 | 10404315 |
| an adhesin of the yeast pathogen candida glabrata mediating adherence to human epithelial cells. | candida glabrata is an important fungal pathogen of humans that is responsible for about 15 percent of mucosal and systemic candidiasis. candida glabrata adhered avidly to human epithelial cells in culture. by means of a genetic approach and a strategy allowing parallel screening of mutants, it was possible to clone a lectin from a candida species. deletion of this adhesin reduced adherence of c. glabrata to human epithelial cells by 95 percent. the adhesin, encoded by the epa1 gene, is likely a ... | 1999 | 10417386 |
| clones of lactobacillus casei and torulopsis glabrata associated with recurrent abdominal wall abscess. | infectious disease caused by lactobacillus sp has not been previously reported in taiwan. we present a case of recurrent abdominal wall abscess in a chronically ill 36-year-old woman, and review the literature on lactobacillus infection. five isolates of l. casei were recovered from blood and pus samples, and two isolates of torulopsis glabrata were isolated from two blood specimens 3 months apart. two clones of l. casei and t. glabrata were identified by means of antibiotyping with the e test a ... | 1999 | 10420704 |
| adherence of candida albicans to bladder mucosa: development and application of a tissue explant assay. | in order to study the interactions between candida species and uroepithelial tissue, a tissue explant assay was developed using bladder mucosa harvested from new zealand white rabbits. blastoconidia of candida albicans, candida tropicalis and candida glabrata attached to the uroepithelial tissue in similar quantities. however, there was significantly more adherence to the uroepithelium by pre-germinated c. albicans compared with c. albicans blastoconidia. furthermore, the amount of uroepithelial ... | 1999 | 10424092 |
| effects of pycnoporellus fulgens (fr.) donk crude extract on candida glabrata ultrastructure. | among antifungal products of natural origin, pycnoporellus fulgens (fr) donk, is active against pathogenic yeasts. our study was carried out to observe the ultrastructural modifications produced by p. fulgens crude extract on candida glabrata. yeasts were submitted to different concentrations (50, 100, 200, 400 micrograms ml-1) for 72 h under constant stirring at 35 degrees c. transmission electron microscopy revealed that the extract acted on the cell envelope (cell wall and plasmalemma). cell ... | 1999 | 10424096 |
| candida glabrata fungemia. clinical features of 139 patients. | candida species are now the fourth leading cause of nosocomial bloodstream infection in hospitalized patients, and non-candida albicans species now surpass candida albicans. the clinical features of the most common non-candida albicans species, candida (torulopsis) glabrata, have not been well studied. we retrospectively reviewed the clinical features of 139 patients with c. glabrata blood-stream infection over a period of 7 years. the mean age of patients was 62 years, and the most common admit ... | 1999 | 10424204 |
| candida (torulopsis) glabrata septic arthritis. | 1999 | 10433591 | |
| [fungemia by candida non albicans in patients with hiv infection]. | to analyse candidemia by candida non albicans in adult hiv-infected patients from 1989 to august 1998. | 1999 | 10439537 |
| a rapid method for detecting and distinguishing clinically important yeasts by heteroduplex mobility assays (hmas). | heteroduplex mobility assays (hmas) of 700 bp amplified products of a 17s rdna region were used to identify and differentiate seven yeast species of clinical importance candida albicans, torulopsis (candida) glabrata, candida tropicalis, candida parapsilosis, candida (pichia) guilliermondii and hansenula (pichia) anomala. distance of heteroduplex migration (dhe) was found to be negatively correlated to the number of nucleotide differences between amplified dna sequences. | 1999 | 10441196 |
| comparative in vitro activity of voriconazole and itraconazole against fluconazole-susceptible and fluconazole-resistant clinical isolates of candida species from spain. | the in vitro activity of voriconazole was compared with that of itraconazole against 299 fluconazole-susceptible (mic < or = 8 microg/ml) and 130 fluconazole-resistant (mic > or = 16 microg/ml) clinical isolates of candida spp. an adaptation of the national committee for clinical laboratory standards reference method was employed for determination of mics. voriconazole showed more potent activity than either fluconazole and itraconazole, even against some candida albicans, candida glabrata, and ... | 1999 | 10442422 |
| functional analysis of a homopolymeric (da-dt) element that provides nucleosomal access to yeast and mammalian transcription factors. | eukaryotic organisms ranging from yeast to humans maintain a large amount of genetic information in the highly compact folds of chromatin, which poses a large dna accessibility barrier to rapid changes in gene expression. the ability of the yeast candida glabrata to survive copper insult requires rapid transcriptional autoactivation of the amt1 copper-metalloregulatory transcription factor gene. the kinetics of amt1 autoactivation is greatly enhanced by homopolymeric (da-dt) element (a16)-mediat ... | 1999 | 10446135 |
| looking for a few good mutants. | 1999 | 10447486 | |
| optimizing voriconazole susceptibility testing of candida: effects of incubation time, endpoint rule, species of candida, and level of fluconazole susceptibility. | voriconazole is a new triazole antifungal agent that has potent activity against many isolates of candida, including candida krusei and candida glabrata. in this work, we studied the impact of glucose supplementation, incubation time, agitation of the plates prior to reading, endpoint determination rule, visual versus spectrophotometric reading, candida species, and fluconazole mic on the mic of voriconazole for candida isolates tested by using the microdilution format assay of the national comm ... | 1999 | 10449447 |
| evolution of vaginal candida species recovered from human immunodeficiency virus-infected women receiving fluconazole prophylaxis: the emergence of candida glabrata? terry beirn community programs for clinical research in aids (cpcra). | the effect of fluconazole prophylaxis on the vaginal flora of 323 human immunodeficiency virus-infected women was evaluated in a multicenter, randomized, double-blind, placebo-controlled trial. women with cd4 cell counts of < or = 300/mm3 received either 200 mg of fluconazole per week or placebo. vaginal surveillance cultures were performed every 3 months. after a follow-up of 29 months, candida albicans was recovered from 53% of patients receiving fluconazole and 68% of patients assigned placeb ... | 1999 | 10452629 |
| candidemia in cancer patients: a prospective, multicenter surveillance study by the invasive fungal infection group (ifig) of the european organization for research and treatment of cancer (eortc). | in a surveillance study of candidemia in cancer patients that was conducted by the european organization for research and treatment of cancer, 249 episodes were noted; candida albicans was isolated in 70% (63) of the 90 cases involving patients with solid tumors (tumor patients) and in 36% (58) of the 159 involving those with hematologic disease (hematology patients). neutropenia in tumor patients and acute leukemia and antifungal prophylaxis in hematology patients were significantly associated ... | 1999 | 10452637 |
| effects of voriconazole on candida glabrata in vitro. | the effects of voriconazole on the growth, morphology and lipids of candida glabrata were studied. mic data showed that voriconazole was up to 32- to 64-fold more active than fluconazole in its ability to inhibit various c. glabrata strains. voriconazole inhibited the growth of c. glabrata in a dose-dependent fashion. electron microscope examination showed that voriconazole treatment affected the external and internal morphology of c. glabrata. treatment of c. glabrata with voriconazole inhibite ... | 1999 | 10459817 |
| [chemotherapy of endocarditis due to candida glabrata]. | 1999 | 10465954 | |
| involvement of calcium inhibitable binding to the cell wall in the fungicidal activity of can-296. | can-296 is a heat stable, complex carbohydrate (molecular mass 4300 da) isolated from the cell wall of the filamentous fungus mucor rouxii. it possesses potent in-vitro fungicidal activity against a wide spectrum of pathogenic yeasts, including azole-resistant isolates of candida albicans and candida glabrata. as a preliminary step in the study of the mode of action of this novel antifungal agent, we investigated the effect of various cations on the antifungal activity as well as the binding of ... | 1999 | 10473228 |
| in-vitro activity of dicationic aromatic compounds and fluconazole against cryptococcus neoformans and candida spp. | we investigated the in-vitro activity of three selected dicationic aromatic compounds for nine clinical isolates of cryptococcus neoformans and 93 clinical isolates of candida spp., representing 12 different species, using a broth macrodilution method following nccls recommendations. all the clinical isolates were also tested for fluconazole susceptibility. the in-vitro data demonstrate that compounds 39 and 57 have excellent in-vitro activity for all tested strains (mic 0.19-1.56 mg/l) except c ... | 1999 | 10473229 |
| national epidemiology of mycoses survey (nemis): variations in rates of bloodstream infections due to candida species in seven surgical intensive care units and six neonatal intensive care units. | candida species are the fourth most frequent cause of nosocomial bloodstream infections, and 25%-50% occur in critical care units. during an 18-month prospective study period, all patients admitted for > or = 72 hours to the surgical (sicus) or neonatal intensive care units (nicus) at each of the participant institutions were followed daily. among 4,276 patients admitted to the seven sicus in six centers, there were 42 nosocomial bloodstream infections due to candida species (9.8/1,000 admission ... | 1999 | 10476721 |
| candidemia in hiv-infected subjects. | the epidemiological features of 37 episodes of candidemia in hiv-infected subjects were analysed in a retrospective matched case-control study conducted over an 8-year period (1990-1997). univariate analysis identified eight risk factors that were significantly associated with candidemia (p<0.05): i) use of central venous catheters; ii) administration of total parenteral nutrition; iii) previous antifungal therapy; iv) previous therapy with glycopeptides; v) presence of oral/ esophageal candidia ... | 1999 | 10482024 |
| comparison of four methodologies for rapid and cost-effective identification of candida glabrata. | to improve turnaround time and decrease the cost of the identification of candida glabrata, we evaluated four methods for the detection of trehalose assimilation or fermentation. these methods were compared with the api 20c method (biomerieux, hazelwood, mo.) to determine accuracy. we recommend the use of remel rapid trehalose assimilation broth because of its rapid, 3-h results, reasonable sensitivity, and low number of false positives. | 1999 | 10488214 |
| comparison of four methods for dna typing of clinical isolates of candida glabrata. | a series of 35 isolates of candida glabrata from 29 subjects (five aids patients and 24 hiv-seronegative individuals) was typed by electrophoretic karyotyping (ek), restriction fragment length polymorphism (rflp) analysis, random amplification of polymorphic dna (rapd) and inter-repeat pcr (ir-pcr). the rank order of discriminatory ability among the four methods was as follows: ek (25 dna types) > rapd (19 dna types) > ir-pcr (14 dna types) > rflp (4 dna types). a composite dna type was defined ... | 1999 | 10510973 |
| in-vitro antifungal activity of liposomal nystatin in comparison with nystatin, amphotericin b cholesteryl sulphate, liposomal amphotericin b, amphotericin b lipid complex, amphotericin b desoxycholate, fluconazole and itraconazole. | the in-vitro susceptibilities of 120 clinical isolates of yeasts to liposomal nystatin were compared with those to amphotericin b lipid complex (ablc), liposomal amphotericin b (lab), amphotericin b cholesteryl sulphate (abcd), amphotericin b desoxycholate, nystatin, fluconazole and itraconazole. yeast isolates examined included strains of candida albicans, candida parapsilosis, candida glabrata, candida krusei, candida guilliermondii, candida tropicalis, candida kefyr, candida viswanathii, cand ... | 1999 | 10511410 |
| candida glabrata arthritis: case report and review of the literature of candida arthritis. | we report a case of arthritis due to candida (torulopsis) glabrata in two different joints at different times in the same patient. the first episode of arthritis was situated in the right ankle and lasted more than 1 year before the patient agreed to the proposed treatment. therapy with intravenous amphotericin b and oral fluconazole failed. a cure was achieved with weekly intra-articular administration of amphotericin b, which was continued for more than 20 weeks and combined with oral itracona ... | 1999 | 10524556 |
| the epidemiology of candidemia in two united states cities: results of a population-based active surveillance. | we conducted prospective, active population-based surveillance for candidemia (defined as any candida species isolated from blood) in atlanta and san francisco (total population, 5.34 million) during 1992-1993. the average annual incidence of candidemia at both sites was 8 per 100,000 population. the highest incidence (75 per 100,000) occurred among infants </=1 year old. in 19% of patients, candidemia developed prior to or on the day of admission. underlying medical conditions included cancer ( ... | 1999 | 10524958 |
| comparative in vitro activity of antiseptics and disinfectants versus clinical isolates of candida species. | to evaluate the in vitro activity of antiseptics and detergents against candida. | 1999 | 10530645 |
| genotypic relatedness of yeast isolates from women infected with human immunodeficiency virus and their children. | the objective of this study was to compare polymerase chain reaction (pcr) fingerprinting with other molecular typing methods as an epidemiologic tool to investigate the transmission of candida strains between hiv-positive mothers and their children. forty-nine yeast strains (including candida albicans, candida glabrata, rhodotorula rubra, candida tropicalis, candida famata, candida dubliniensis, saccharomyces cerevisiae) from 30 individuals (15 children and 15 hiv-infected mothers or accompanyi ... | 1999 | 10536430 |
| fungal surveillance cultures during antifungal prophylaxis with itraconazole in neutropenic patients with acute leukaemia. | fungal colonization has been associated with an increased rate of invasive fungal infections in neutropenic patients. this study evaluates weekly fungal surveillance cultures from the oropharyngeal and perianal space as well as other suspected sites in 219 courses of myelosuppressive chemotherapy with itraconazole antifungal prophylaxis in 116 neutropenic patients with acute leukaemia. itraconazole was given from the start of chemotherapy in one of six different dosing regimens. fungal colonizat ... | 1999 | 10536431 |