Publications

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letter: long-term gold salt therapy. 20164832169
effect of pge2 on the turnover of calcium in rat uterus. 19744833687
[experience with ultraviolet irradiation of the blood in chronic diseases]. 20164837149
[background factors relating to the delay in hospitalization analyzed among recently hospitalized patients of pulmonary tuberculosis (author's transl)]. 20114845630
group exposure (flooding) in vivo for agoraphobics. 20164852186
cycloheximide induced amnesia and recovery as a function of training parameters. 20164857294
serotyping of proteus rettgeri on the basis of o antigens. 19744857623
treatment of gastrointestinal cancer: current status and recent progress. 20164860338
spinal fluid cytomorphology. description of apparatus, technique, and findings. 20164862475
effect of previous injection of homologous embryonic tissue on the growth of certain transplantable mouse tumours. 19674862516
[autoimmune hepatitis]. 20164865241
benjamin rush, m. d. (1745-1813). 20164875618
effects of propranolol and isosorbide dinitrate on exercise performance and adrenergic acitivity in patients with angina pectoris. 20164884575
asthmatic hyperresponsiveness. 20164885824
the asparagine synthetase of escherhic coli. i. biosynthetic role of the enzyme, purification, and characterization of the reaction products. 19694895361
a technique for studying biological reaction rates at high pressure. 20144897388
drug induced retinopathy. 20164902422
trachoma among the navajo indians. 19704904035
[etiological frequency of purulent meningitis]. 19684909030
supplementary impressions for crowns and bridges. 20164912412
a histologic reappraisal of the thymus in myasthenia gravis. a correlative study of thymic pathology and response to thymectomy. 20164922629
[studies on the functional and morphological changes after unilateral and bilateral lung reimplantation with special reference to the neural regulation of respiration without the hering-breuer reflex]. 19694923195
infectious resistance to carbenicillin in proteus rettgeri: occurrence of two different penicillinases in the same strain. 19714929467
experimental approaches to the stem cell problem in postnatal life. 19714938530
characterization of an unusual strain of proteus rettgeri associated with an outbreak of nosocomial urinary-tract infection.an outbreak of nosocomial urinary-tract infection was caused by a strain of proteus rettgeri that fermented lactose overnight and was resistant to all antimicrobial drugs tested. the nonmotile isolates shared an o (somatic) antigen that differed from those of wild-type p. rettgeri. the organisms proved markedly serum-sensitive. in rats, the isolates elicited an acute interstitial nephritis with associated transient bacteriuria. attempts to transfer the lac(+) trait and drug-resistance markers to ...19714940869
the genetic effects of ionizing radiations. 19714947106
bacteriocinogeny in proteus rettgeri. 19714947915
teratogenesis of craniofacial malformations in animals. 3. natural and experimental cephalic deformities in sheep. 19664958863
pyriformsinusosotomy. a useful technique for temporary or permanent tube feeding. 20164959520
gastrointestinal parasites of farm animals in eastern nigeria. 19664961677
lassa fever, a new virus disease of man from west africa. iv. electron microscopy of vero cell cultures infected with lassa virus. 19704987548
[differentiation of streptococcus faecalis andrewes a. horder from str. faecium orla-jensen by physiological characteristics]. 19704996135
purification and biochemical characteristics of urease from proteus rettgeri. 19715001086
incidence of primary carcinoma of the ureter: a report of five cases. 20165005322
the fluorescence from the tryptophans of rhodopsin. 19725034101
carcinoma of breast. influence of size of primary lesion and lymph node involvement based on selective biopsy. 20165045884
protein-alkaloid relationship in datura stramonium var. tatula. 20165050374
[mechanism of action of erythropoietin on energy metabolism of bone marrow]. 19725050574
[results of controlled ophthalmologic studies during hormonal contraception using ovosiston]. 20155064445
serum enzyme levels during exercise in patients with coronary heart disease: effects of training. 20165075087
cellular immunity: alterations of macrophage functions by mediators from lymphocytes. 19725077115
[isolation of a proteus rettgeri phenylalanine negative strain]. 19715147517
arylsulfatase multiplicity in proteus rettgeri. 19705491277
a transducing bacteriophage for proteus rettgeri. 19695795919
[on the production of colonies with orange centers by proteus rettgeri and providencia on desoxycholate-citrate-lactose agar]. 19655869294
the inactivation and reactivation of a proteus rettgeri phage in salt solutions. 19665963332
a study of arylsulfatase activity in proteus rettgeri. 19665969336
mechanisms of regulation of urease biosynthesis in proteus rettgeri.urease of proteus rettgeri is an inducible enzyme synthesized specifically in the presence of urea; urea analogues did not act as inducers. once initiated, the biosynthesis of the enzyme proceeded as a constant fraction of the total protein formed. the rate of urease formation was affected by the carbon source used. in comparison with glycerol, glucose inhibited enzyme synthesis. the addition of ammonium ions to the inducing medium also decreased the rate of urease biosynthesis, and when ammoniu ...19676032508
the effect of some cultural conditions on the arylsulfatase of proteus rettgeri. 19676035143
regulation by repression of urease biosynthesis in proteus rettgeri.measuring the specific enzyme activity in cells of proteus rettgeri it was shown that urease formation is controlled by repression through ammonia. derepressed synthesis of the enzyme, as initiated by the absence of ammonia, required an external nitrogen source, which may not only be urea, but also nitrate, glutamate or nutrient broth. in contradiction to earlier reports the observations indicated that urea is not required for the synthesis of this enzyme, and that, therefore, urease is not an i ...19826126049
in vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim.norfloxacin is a quinolinecarboxylic acid compound. we examined the in vitro activity of this compound against gram-positive and -negative species, including anaerobic species. it inhibited 90% (mic90) of strains of escherichia coli at 0.05 microgram/ml, klebsiella sp. at 0.4 microgram/ml, salmonella and shigella spp. at 0.1 microgram/ml, citrobacter sp. at 0.4 microgram/ml, enterobacter cloacae at 0.2 microgram/ml, enterobacter aerogenes at 0.4 microgram/ml, and enterobacter agglomerans at 0.2 ...19826214995
in vitro activity of moxalactam against pathogenic bacteria and its comparison with other antibiotics.843 isolates from clinical specimens were tested against moxalactam by disc agar diffusion. the bacteria used in this study consisted of escherichia coli, enterobacter aerogenes, enterobacter agglomerans, enterobacter cloacae, klebsiella pneumoniae, proteus mirabilis, providencia rettgeri, pseudomonas aeruginosa, serratia marcescens, staphylococcus aureus, staphylococcus epidermidis and group b and group d streptococci. in vitro activity of moxalactam was compared with the following antibiotics: ...19836219865
aminoglycoside antibiotics. 3. epimino derivatives of neamine, ribostamycin, and kanamycin b.2',3'-epimino analogues of neamine, ribostamycin, and kanamycin b possessing little or no intrinsic antimicrobial activity were designed to enhance the activity of kanamycin a against bacterial strains that elaborate aminoglycoside 3'-phosphotransferases. routes were devised for their synthesis from the parent antibiotics and the 2'',3''-epimino analogue of kanamycin b also was prepared. none of these analogues was active against phosphotransferase-producing bacteria, although the kanamycin b de ...19806244410
lethal effect of polymyxin b sulfate in experimental proteus rettgeri infection in mice.the mouse model of intraperitoneal sepsis with proteus rettgeri was used to evaluate the anti-endotoxic effect of polymyxin b sulfate. an unexpected reversal of the usual protective effect of polymyxin in experimental enterobacterial sepsis was observed in which the lethality of the infection was enhanced.19806250690
assay of cefotaxime by high-pressure-liquid chromatography.a high-pressure-liquid chromatographic (hplc) procedure for quantitative assay of cefotaxime (ct) and its major metabolite in serum of normal individuals, desacetyl cefotaxime (dact), is described. it employs lichrosorb rp-8, elution with phosphoric-acid-methanol and uv absorption at 310 nm. the method is optimized for cefotaxime and allows differentiation between the parent compound and the biotransformation product dact. the lower assay sensitivity level of ct and dact is 0.3 microgram/ml. cor ...19816262021
effect of combination of cefsulodin and mecillinam.the effect of cefsulodin in combination with mecillinam was examined against a wide range of bacterial species. the antibacterial spectrum was widened by the combination of cefsulodin and mecillinam in the ratio of 5:1 and 10:1. in overall observations, in the in vitro test, a synergistic effect against clinical isolates was found on klebsiella pneumoniae, citrobacter freundii, enterobacter cloacae, serratia marcescens, proteus mirabilis and proteus vulgaris, and an additive effect was found on ...19816268593
[antibacterial activities of cefotiam against various pathogens isolated from clinical materials (author's transl)].bacteriological evaluation was made on cefotiam (ctm), a new broad-spectrum cephalosporin antibiotic, and the following results wer obtained. 1) ctm has shown very potent antibacterial activities against staphylococcus aureus, escherichia coli, edwardsiella tarda, citrobacter intermedius, salmonella, klebsiella, proteus mirabilis, proteus rettgeri, proteus inconstans, yersinia enterocolitica, aeromonas hydrophila, plesiomonas shigelloides and pseudomonas putrefaciens. 2) streptococcus faecalis, ...19826285018
synergistic activity of mecillinam in combination with the beta-lactamase inhibitors clavulanic acid and sulbactam.the beta-lactamase inhibitors clavulanic acid and sulbactam were combined with mecillinam. beta-lactamase-containing escherichia coli resistant to mecillinam was synergistically inhibited by both clavulanic acid and sulbactam. beta-lactamase-containing enterobacter was synergistically inhibited, but strains lacking beta-lactamases were not synergistically inhibited. synergistic inhibition was noted for beta-lactamase-containing, mecillinam-resistant klebsiella, citrobacter, serratia, and salmone ...19826291454
[clinical evaluation of the method to determine antibiotic concentrations in small amounts of samples].concentrations of cefotiam (ctm) in the exudate after abdominal operation were studied. the exudates were collected by 6 mm paper discs and the antibiotic concentrations were determined by the paper disc method using proteus rettgeri atcc 9250 as test organism. comparison between agar well and paper disc assay for ctm in ascites specimens showed good correlation. two grams of ctm was intravenously given to the patients after abdominal operations. the concentration of ctm in the exudate for 6 hou ...19836325751
comparative in vitro activity and beta-lactamase stability of fr 17027, a new orally active cephalosporin.fr 17027, a new orally absorbed cephalosporin ester, inhibited group a and b streptococci and streptococcus pneumoniae at less than or equal to 0.1 micrograms/ml, which is similar to the inhibition concentration of amoxicillin and cefaclor, and was more active than cephalexin. it was less active (mic, 25 micrograms/ml) against staphylococci than was cephalexin, and it did not inhibit streptococcus faecalis or listeria monocytogenes. fr 17027 inhibited beta-lactamase-producing isolates of neisser ...19846333207
inactivation of cephalosporins by beta-lactamases of gram-negative rods.intracellular beta-lactamase activity of gram-negative rods (four pseudomonas aeruginosa strains, one strain each of enterobacter cloacae, proteus rettgeri, providencia stuartii and serratia marcescens) was greatly increased by subinhibitory concentrations of cefoxitin, with the exception of one p. aeruginosa strain. cefotaxime, cefoperazone and ceftazidime were much less effective as enzyme inducers in these strains. a reduction in beta-lactamase activity after pre-incubation with cephalosporin ...19836339417
in vitro antibacterial activity of moxalactam, a new broad-spectrum semisynthetic antibiotic.the antibacterial activity of moxalactam was studied in vitro against 229 clinical isolates of gram-positive and gram-negative aerobic microorganisms using the agar dilution technique. mueller-hinton agar was used as growth medium. the results were compared to those obtained with cefamandole. all isolates of staphylococcus aureus and streptococcus pneumoniae were inhibited by moxalactam at a concentration of 8 microgram/ml or less. the concentrations of cefamandole with which the same effect was ...19806447672
growth of clinical isolates in the cold.common clinical isolates were tested to determine their ability to multiply after 7 days at 4 degrees c in trypticase soy broth. 34% of the 214 isolates grew in the cold. citrobacter freundii, group d enterococci, klebsiella oxytoca, proteus vulgaris, providencia rettgeri and serratia marcescens grew best of all. the importance of growth in the cold is discussed.19846472199
comparative evaluation of the eiken and api 20e systems and conventional methods for identification of members of the family enterobacteriaceae.to evaluate the accuracy and utility of the eiken systek no. 1 (eiken system; eiken chemical co., ltd., tokyo, japan), we conducted a clinical comparison, with 345 enterobacteriaceae isolates, of the eiken system with api 20e (analytab products, inc., plainview, n.y.) and conventional methods. the eiken system is a 21-biochemical-test battery tray stored at 25 degrees c and inoculated in one step. it is similar to the api 20e except that the eiken system contains malonate, adonitol, and maltose; ...19846490860
in vitro study of the sensitivity of 1030 hospital-isolated bacterial strains to aztreonam.the antibacterial activity in vitro of aztreonam is compared with other antibiotics on 1,030 strains isolated from pathological specimens. its spectrum is very large, with special regard to gram-negative bacteria. of particular interest appears the sensitivity to aztreonam of otherwise multiresistant strains of pseudomonas aeruginosa and proteus rettgeri.19846543433
cefotetan: profile of in-vitro activity.cefotetan, a novel 7 alpha-methoxy cephalosporin, was shown to be comparable to other third-generation cephalosporins when tested in vitro against 1063 gram-negative clinical isolates of 11 species. ninety per cent of all isolates of escherichia coli, klebsiella, proteus mirabilis, proteus vulgaris, proteus rettgeri, providencia stuartii, serratia marcescens and citrobacter freundii were inhibited by concentrations of cefotetan between 0.07 and 3.2 mg/l. activity against gram-positive cocci was ...19836601656
antibacterial activity of aztreonam: a synthetic monobactam. a comparative study with thirteen other antibiotics.the in vitro activity of aztreoman (sq 26, 776), a new monocyclic beta-lactam antimicrobial agent, was determined against 1720 bacteria, all clinical isolates, and compared with that of thirteen beta-lactam and aminoglycoside antibiotics. aztreonam inhibited 90% of citrobacter diversus, citrobacter freundii, enterobacter agglomerans, e. coli, klebsiella pneumoniae, proteus mirabilis, proteus morganii, proteus rettgeri, proteus vulgaris and salmonella sp. by less than or equal to 0.4 micrograms m ...19836684718
effects of different forms of dialytic treatment on serum antibacterial activity in patients with chronic renal failure.the antibacterial activity of fresh and heat-inactivated normal serum was compared with that of sera from patients with renal failure: 16 on diet, 9 on regular hemodialysis (hd) and 9 on continuous ambulatory peritoneal dialysis (capd). the antibacterial activity was determined on proteus rettgeri (sanelli) by a turbidimetric method. the inhibitory activity of fresh serum was only slightly decreased in nondialyzed uremic patients, whereas it was significantly impaired in capd and hd patients. he ...19846709115
correlation of beta-lactamase production and resistance to beta-lactam antibiotics in enterobacteriaceae.incidence of beta-lactamase production (using the nitrocefin test and isoelectric focusing) was evaluated on 284 strains of ampicillin-resistant enterobacteriaceae. production of the various beta-lactamases was correlated with the resistance to different beta-lactam antibiotics. no obvious correlation between the beta-lactamase production and the resistance pattern was found. the most striking result was the lack of beta-lactamase production in 42.6% of the strains. about 50% or more of the prot ...19826758422
inducer activity of beta-lactam antibiotics for the beta-lactamases of proteus rettgeri and proteus vulgaris. 19826761329
short-course aminoglycoside therapy in patients with spinal cord injury. standard dose versus low dose.twenty-nine patients with spinal cord injury and asymptomatic urinary tract infection were treated with standard or reduced doses of tobramycin and amikacin. the patients received five days of intramuscular antibiotics. most of the patients in the tobramycin groups had pseudomonas aeruginosa infection and most of those in the amikacin group had either proteus rettgeri or providencia stuartii infections. only 1 patient had a positive urine antibody coating test. high antibiotic concentrations wer ...19806763394
penicillin amidase from proteus rettgeri.1. penicillin amidase from proteus rettgeri was purified 580-fold by a four-step chromatographic procedure. titration with phenylmethanesulphonyl fluoride showed that the purified preparation contains 53% of the enzyme. 2. the molecular weight of the amidase was found to be 65.000. the enzyme is strongly inhibited by n-bromosuccinimide and zinc ions. it hydrolyses penicillins, cephalosporins and some synthetic substrates, and in addition it catalyses synthesis of ampicillin from methyl ester of ...19816805183
antibacterial activity and beta-lactamase stability of ceftazidime, an aminothiazolyl cephalosporin potentially active against pseudomonas aeruginosa.the in vitro activity and beta-lactamase stability of ceftazidime were evaluated against 700 gram-positive and gram-negative bacteria. ceftazidime was less active than penicillins or older cephalosporins against staphylococcus spp. and streptococcus spp., and it did not inhibit streptococcus faecalis, listeria, or anaerobic species. ceftazidime was as active as ceftizoxime and moxalactam and more active than cefoperazone against escherichia coli. klebsiella, and proteus mirabilis with minimal in ...19826805421
providencia rustigianii: a new species in the family enterobacteriaceae formerly known as providencia alcalifaciens biogroup 3.the name providencia rustigianii sp. nov. is proposed for a group of organisms previously known as providencia alcalifaciens biogroup 3. by dna hybridization, strains of p. rustigianii were 81 to 99% related to each other at 60 degrees c, but only 44 to 49% related to p. alcalifaciens biogroups 1 and 2 and 26 to 33% related to providencia stuartii. p. rustigianii could be differentiated from p. alcalifaciens and p. stuartii by simple biochemical tests. p. rustigianii produced acid from d-galacto ...19836874899
resistance factors: influence on netilmicin activity.netilmicin is active against many but not all bacterial strains that have acquired resistance to aminoglycosides. generally, netilmicin is 1) active against strains that produce enzymes inhibiting aminoglycosides by phosphorylation or adenylation. some of these enzymes are widely distributed in aminoglycoside resistant strains, e.g. the adenylating enzyme ant(2") predominating in resistant klebsiella and common in resistant pseudomonas and serratia strains. netilmicin either lacks the hydroxyl g ...19806937969
purification and biochemical properties of beta-lactamase produced by proteus rettgeri.beta-lactamase produced by proteus rettgeri was found to be a typical cephalosporin beta-lactamase on the basis of its substrate hydrolysis profile. the enzyme activity was enhanced by prior treatment with an inducer. the enzyme was purified 166-fold by carboxymethyl-sephadex column chromatography which indicated that its molecular weight was 42,000 +/- 2,000 and its isoelectric point was 8.7. cefoperazone, cefoxitin, cefusulodin, cefmetazole, cefotaxime, 6059-s, fk749, ym-09330, carbenicillin, ...19806969578
purification and some properties of beta-lactamases from proteus rettgeri and proteus inconstans.two beta-lactamases were isolated from strains of proteus species and purified, one from a strain of p. rettgeri and the other from a strain of p. inconstans. each enzyme preparation gave a single protein band on polyacrylamide gel electrophoresis. molecular weights of p. rettgeri and p. inconstans enzymes were found to be 42,000 and 43,000, and their isoelectric points ph 8.7 and 8.6, respectively. the two enzymes presented typical cephalosporinase profiles. cefmetazole (cs-1170) and cefoxitin, ...19806971391
potent cephalosporinase inhibitors: 7 beta-[2-(1, 3-dithiolan-2-ylidene) acetamido] cephalosporins and related compounds.cephalosporins possessing a 1, 3-dithiolane, 1, 3-dithiane, or 1, 3-dithietane ring on their 7 beta-substituents showed potent inhibitory activity against cephaloridine hydrolysis by cephalosporinases purified from proteus morganii, proteus rettgeri, and proteus inconstans, which were not inhibited by clavulanic acid, a well-known beta-lactamase inhibitor. the mode of inhibition was competitive. the dithiolane cephalosporins themselves were stable against hydrolysis by the beta-lactamases tested ...19826979310
the effect of acetohydroxamic acid on the induction of bacterial ureases.the ureases of proteus mirabilis, proteus vulgaris, and proteus rettgeri are inducible by urea. induction is increased when both urea and acetohydroxamic acid, an inhibitor of urease, are present during bacterial growth. acetohydroxamic acid alone does not cause induction, but, by preventing the hydrolysis of urea, it minimizes ph increases and allows induction to occur much more effectively. the ureases of proteus morganii and other bacterial genera are not inducible by this method. the relevan ...19806997229
urinary tract infection in patients with spinal cord lesions: antibody-coated bacteria tests as a diagnostic aid.urine cultures and antibody-coated bacteria (acb) tests were performed on urine specimens from 176 spinal cord injured patients at the time of annual renal function follow-up. sixty-nine percent of the cultures were positive; and of these, 55% were positive for acb. the highest incidence of positive acb tests occurred in the specimens from patients with external catheters (67%), ileal diversions (63%) and suprapublic catheters (60%). the organisms which occurred most frequently as a single isola ...19806998411
proteus-typing by proticin production and susceptibility.a proteus-typing method based on proticin production and proticin susceptibility (c.f. senior, 1977) has been modified to increase its sensitivity proticins were prepared in fluid medium and applied to agar-plates shortly before seeding the plates with indicator bacteria. a given 10 proticin producer strains, which are responsible for the susceptibility patterns of the indicator-bacteria (s-types), form the foundation for this typing method. using this producer-set and indicator-set (28 strains) ...19817039501
repression of penicillin g acylase of proteus rettgeri by tricarboxylic acid cycle intermediates.the regulation of the penicillin acylase in proteus rettgeri atcc 31052 was compared with that of the enzyme in escherichia coli atcc 9637. unlike the e. coli acylase, the p. rettgeri enzyme was not induced by phenylacetic acid, nor was it subject to catabolite repression by glucose. the p. rettgeri acylase appears to be expressed constitutively but is subject to repression by the c4-dicarboxylic acids of the tricarboxylic acid cycle, succinate, fumarate, and malate.19827118826
[molecular characterization of plasmids of proteus rettgeri]. 19817306392
patterns of oral bacterial infection in captive snakes.the bacterial isolates from culture specimens of snakes with infectious stomatitis were compared with those from culture specimens of the oral cavity of healthy captive snakes. cloacal swab specimens were also taken from healthy snakes to compare their intestinal and oral bacterial populations. the healthy snakes had a predominantly gram-positive oral flora, with corynebacterium spp and coagulase-negative staphylococcus spp being the organisms isolated most frequently. the specimens from snakes ...19817328007
in vitro and in vivo antibacterial activities of fr-31564, a new phosphonic acid antibiotic.fr-31564, a new phosphonic acid antibiotic, was active against most gram-negative bacteria except serratia marcescens and glucose-nonfermenting gram-negative rods excluding pseudomonas aeruginosa. the antibacterial activity in vitro of fr-31564 was stronger than that of fosfomycin especially against escherichia coli, klebsiella pneumoniae, enterobacter species and p. aeruginosa. fr-31564 also was active against gram-negative bacteria resistant to beta-lactam antibiotics and against gentamicin-re ...19807372548
reappraisal of the significance of multiply resistant urinary isolates of proteus rettgeri. 19807430015
bacterial agents causing chronic suppurative otitis media.ear swabs from 350 patients with chronic otitis media attending different orthorhinolaryngological clinics at different hospitals and health centres in benin city and ekpoma in edo state were screened for the presence of bacterial agents of chronic otitis media. results revealed the presence of 19 different species indicating polymicrobial infections. species isolated comprised staphylococcus aureus (33.6%), pseudomonas aeruginosa (19.3%), proteus mirabilis (17%), alcaligenes faecalis (6.2%) and ...19957498006
loss of porins following carbapenem-resistance selection and adherence modification in enterobacteria.the acquired resistance to the carbapenems is frequently joined to modified expression of porins or other outer membrane (om) structures, thus bacterial adherence, that also depends on the presence of peculiar surface structures, might theoretically be influenced. in this study the ability to adhere to hep-2 and i-407 eukaryotic cell monolayers was assayed for two susceptible strains of serratia marcescens, one strain of enterobacter cloacae and one of providencia rettgeri in comparison with tha ...19957562008
different biological conditions influencing bacterial adherence assay.adherence of bacteria to animal cells is considered the first step in the pathogenesis of many infectious diseases. the most suitable techniques developed in vitro to check the capacity of bacteria to adhere to different tissues use monolayers of established cell lines. we studied the influence of incubation time (1, 2, 3 hours), cell substrates (hep-2, h-407) and the number of bacteria per cell (1, 10, 100, 1000) on the adherence index (number of adherent bacteria per cell determined by microsc ...19957629566
effect of salicylate on expression of flagella by escherichia coli and proteus, providencia, and pseudomonas spp.osmotic stress, salicylate, and mar (multiple antibiotic resistance) mutation are known to block the expression of the ompf porin. since these conditions have also been shown to inhibit the expression of p and cfa fimbriae in escherichia coli, we speculated that they might affect the expression of flagella as well. hyperosmotic conditions have been shown to block the synthesis of flagellin and expression of flagella in e. coli (c. li, c. j. louise, w. shi, and j. adler, j. bacteriol. 175:2229-22 ...19957729888
purification and preliminary crystallographic studies of penicillin g acylase from providencia rettgeri.two isoforms of the heterodimeric enzyme penicillin g acylase (ec 3.5.1.11) from providencia rettgeri atcc 31052 (strain bro1) were purified to near homogeneity. the isoforms exhibited comparable enzymatic activities but differed slightly in the molecular weight and pi of their respective alpha-subunit. the origin of this difference was traced to the partial conversion of the n-terminal gln of the alpha-subunit to pyrrolidonecarboxylic acid (pyro-glu). the boundaries of the mature enzyme within ...19957795527
isolation of three hexahydro-1,3,5-trinitro-1,3,5-triazine-degrading species of the family enterobacteriaceae from nitramine explosive-contaminated soil.three species of the family enterobacteriaceae that biochemically reduced hexahydro-1,3,5-trinitro-1,3,5-triazine (rdx) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (hmx) were isolated from nitramine explosive-contaminated soil. two isolates, identified as morganella morganii and providencia rettgeri, completely transformed both rdx and the nitroso-rdx reduction intermediates. the third isolate, identified as citrobacter freundii, partially transformed rdx and generated high concentratio ...19947811097
in vitro activity of subinhibitory concentrations of quinolones on urea-splitting bacteria: effect on urease activity and on cell surface hydrophobicity.the effect of subinhibitory concentrations of ciprofloxacin, lomefloxacin, norfloxacin, ofloxacin, and sparfloxacin on urease activity and on cell surface hydrophobicity of urea-splitting bacteria was examined. quinolones at 0.5 mics demonstrated variable effects on bacterial-urease activity. norfloxacin inhibited enzyme activity in proteus vulgaris and proteus mirabilis, while other quinolones had no effects. in morganella morganii, sparfloxacin and ciprofloxacin enhanced urease activity, parti ...19957844396
update of lomefloxacin in vitro activity and spectrum. a multicenter trial testing contemporary pathogens following food and drug administration validation guidelines. lomefloxacin activity study group.the united states food and drug administration recently recommended that the antimicrobial product package insert (ppi) subsection on microbiology be annually validated with regard to the compound's spectrum and potency. to address this request, a nine-laboratory trial was organized to test (two methods) lomefloxacin, a newer fluoroquinolone, and nine comparison drugs against ppi-listed pathogens (1934 strains). a broad geographic sampling (nine medical centers) was achieved, and lomefloxacin wa ...19947867311
in vitro activity of the new fluoroquinolone cp-99,219.the in vitro activity of the new fluoroquinolone cp-99,219 [7-(3-azabicyclo[3.1.0]hexyl)naphthyridone] was compared with those of four other quinolones against 541 gram-negative, 283 gram-positive, and 70 anaerobic bacterial isolates. cp-99,219 inhibited 90% of many isolates in the family enterobacteriaceae at a concentration of < or = 0.25 micrograms/ml (range, < 0.008 to 1 microgram/ml), an activity comparable to those of tosufloxacin and sparfloxacin and two times greater than that of temaflo ...19947872757
microbiological studies of abscesses complicating bothrops snakebite in humans: a prospective study.forty patients with abscesses at the site of bothrops bite were evaluated. ten brought the snake responsible for the bite, bothrops jararaca in all cases. on admission a sample was collected from each case for aerobic and anaerobic culture, and no abscesses drained spontaneously. none of the patients had received antibacterial therapy at this time. the bacteria most frequently isolated were morganella morganii (23 patients), providencia rettgeri (7) enterobacter sp. (4), escherichia coli (3), gr ...19947940580
[antibacterial activity of aztreonam against clinical isolates].to evaluate the antibacterial activity of a monobactam antibiotic, aztreonam (azt), mics of azt and other antibiotics against clinical isolates collected at 36 participating institutions after january 1992 were determined using the agar plate dilution method (size of inoculum, 10(6) cfu/ml) according to the japan society of chemotherapy standard. the antibiotics that were tested along with azt included piperacillin (pipc), cefoperazone (cpz), and amikacin (amk). azt was found to be more active a ...19948051793
levofloxacin in vitro activity: results from an international comparative study with ofloxacin and ciprofloxacin.levofloxacin, the s-(-)-isomer of ofloxacin, was compared to ofloxacin and ciprofloxacin against > 6000 recent clinical isolates of gram-positive and gram-negative bacteria from six different countries. this international multicenter study demonstrated a high level of antibacterial activity of levofloxacin against all the members of enterobacteriaceae [minimum inhibitory concentration (mic)50s, < or = 0.03 to 0.12 mg/l] except providencia rettgeri (mic50, 2 mg/l), and providencia stuartii (mic50 ...19948077990
in vitro comparison activity of opc-17116, a new fluoroquinolone, against more than 5,000 recent clinical isolates from five medical centers.the in vitro activity of opc-17116, a new fluoroquinolone, was compared with those of ciprofloxacin, ofloxacin and cefixime. a total of 5,231 fresh clinical isolates from five geographically separate us medical centers were tested. the primary results of this study are: 1. opc-17116 is very active against enterobacteriaceae [mic90s, 0.015-1 microgram/ml, except providencia rettgeri (mic90, > 8 micrograms/ml)], 2. among nonenteric gram-negative bacilli (e.g. xanthomonas maltophilia, mic90, 2 micr ...19938106899
in vitro activity of du-6859a, a new fluorocyclopropyl quinolone.du-6859a was tested against 844 recent clinical isolates (most from bacteremias) by using reference mic determination procedures. the activity of du-6859a against members of the family enterobacteriaceae was comparable to that of ciprofloxacin (range of mics for 90% of isolates [mic90], < or = 0.015 to 1 microgram/ml), and the highest mics were observed among serratia marcescens and providencia rettgeri isolates. the du-6859a mic90 for pseudomonas aeruginosa and xanthomonas maltophilia was 0.5 m ...19938109948
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