Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| serum igg antibody levels to periodontal microbiota are associated with incident alzheimer disease. | periodontitis and alzheimer disease (ad) are associated with systemic inflammation. this research studied serum igg to periodontal microbiota as possible predictors of incident ad. | 2014 | 25522313 |
| distribution of 8 periodontal microorganisms in family members of chinese patients with aggressive periodontitis. | to date, no information on the distribution of periodontal microorganisms among family members of chinese patients with aggressive peridontitis (agp) is available. the aim of the present study was to investigate the probability of transmission of eight periodontal microorganisms between patients with aggressive periodontitis and their family members. | 2015 | 25526624 |
| microbial leakage at the implant-abutment connection due to implant insertion maneuvers: cross-sectional study 5 years postloading in healthy patients. | the aim of this study was to test if stress on the prosthetic connection during insertion maneuvers can induce micro-warping at the implant connection. from september 2011 to july 2013, patients with implants loaded for at least 5 years that were placed with 2 different insertion implant mounters-mp (conventional) and me (mountless)-were selected from all of those who had received dental implant therapy in the past and were attending routine check-up or spontaneous visits during the study period ... | 2015 | 25536224 |
| effects of adjunctive daily phototherapy on chronic periodontitis: a randomized single-blind controlled trial. | the purpose of this randomized single-blind controlled trial was to elucidate the clinical and antimicrobial effects of daily phototherapy (pt) as an adjunct to scaling and root planing (srp) in patients with chronic periodontitis. | 2014 | 25568808 |
| inhibition of sphingosine kinase prevents lipopolysaccharide-induced preterm birth and suppresses proinflammatory responses in a murine model. | premature delivery occurs in 12% of all births, and accounts for nearly half of long-term neurological morbidity, and 60% to 80% of perinatal mortality. despite advances in obstetrics and neonatology, the rate of premature delivery has increased approximately 12% since 1990. the single most common cause of spontaneous preterm birth is infection. several lines of evidence have demonstrated the role of endothelin-1 as both a constrictor of uterine myometrial smooth muscle and a proinflammatory med ... | 2015 | 25579843 |
| establishment of an oral infection model resembling the periodontal pocket in a perfusion bioreactor system. | periodontal infection involves a complex interplay between oral biofilms, gingival tissues and cells of the immune system in a dynamic microenvironment. a humanized in vitro model that reduces the need for experimental animal models, while recapitulating key biological events in a periodontal pocket, would constitute a technical advancement in the study of periodontal disease. the aim of this study was to use a dynamic perfusion bioreactor in order to develop a gingival epithelial-fibroblast-mon ... | 2015 | 25587671 |
| association between periodontal condition and subgingival microbiota in women during pregnancy: a longitudinal study. | in this study, the gingival conditions and the quantitative detection for aggregatibacter actinomycetemcomitans, fusobacterium nucleatum, porphyromonas gingivalis and prevotella intermedia in pregnant women were determined. | 2014 | 25591021 |
| identification and characterization of a putative chemotaxis protein, chey, from the oral pathogen campylobacter rectus. | campylobacter rectus is an understudied oral bacterium that contributes to periodontitis. processes that contribute to the disease-causing capabilities of pathogens, such as chemotaxis, are largely unknown in c. rectus. the aim of this study was to better understand c. rectus chemotaxis, by examining the c. rectus genome for the presence of a chey gene. chey proteins play a part in chemotaxis by acting as two-component response regulators. significantly, chey proteins from several pathogens, inc ... | 2014 | 25598863 |
| relationship between invasion of the periodontium by periodontal pathogens and periodontal disease: a systematic review. | bacterial invasion of the periodontal tissues has been suggested as a relevant step in the etiopathogenesis of periodontal disease. however, its exact importance remains to be defined. the present systematic review assessed the scientific evidence concerning the relationship between the quality or quantity of periodontal microbiota in periodontal tissues and development of periodontal disease. the databases medline-pubmed, cochrane-central, isi web of knowledge and scopus were searched, up to ja ... | 2015 | 25654367 |
| anaerobic culture to detect periodontal and caries pathogens. | anaerobic culture has been critical in our understanding of the oral microbiotas. | 2014 | 25678835 |
| anaerobic culture to detect periodontal and caries pathogens. | anaerobic culture has been critical in our understanding of the oral microbiotas. | 2014 | 25678835 |
| effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model. | chronic periodontitis is one of the most prevalent human diseases and is caused by dysbiosis of the subgingival microbiota. treatment involves primarily mechanical disruption of subgingival biofilms and, in certain cases, adjunctive use of systemic antibiotic therapy. in vitro biofilm models have been developed to study antimicrobial agents targeting subgingival species. however, these models accommodate a limited number of taxa, lack reproducibility, and have low throughput. we aimed to develop ... | 2015 | 25733510 |
| quantitative proteomics reveal distinct protein regulations caused by aggregatibacter actinomycetemcomitans within subgingival biofilms. | periodontitis is an infectious disease that causes the inflammatory destruction of the tooth-supporting (periodontal) tissues, caused by polymicrobial biofilm communities growing on the tooth surface. aggressive periodontitis is strongly associated with the presence of aggregatibacter actinomycetemcomitans in the subgingival biofilms. nevertheless, whether and how a. actinomycetemcomitans orchestrates molecular changes within the biofilm is unclear. the aim of this work was to decipher the inter ... | 2015 | 25756960 |
| abnormal pregnancy outcomes in mice using an induced periodontitis model and the haematogenous migration of fusobacterium nucleatum sub-species to the murine placenta. | to investigate if there is subspecies specific migration to the placenta by fusobacterium nucleatum (fn) and to determine whether experimentally induced periodontitis results in adverse pregnancy outcomes (apo) in mice. | 2015 | 25806806 |
| comparison of oral microbial profiles between children with severe early childhood caries and caries-free children using the human oral microbe identification microarray. | early childhood caries (ecc) has become a prevalent public health problem among chinese preschool children. the bacterial microflora is considered to be an important factor in the formation and progress of dental caries. however, high-throughput and large-scale studies of the primary dentition are lacking. the present study aimed to compare oral microbial profiles between children with severe ecc (secc) and caries-free children. | 2015 | 25821962 |
| microbiota at teeth and implants in partially edentulous patients. a 10-year retrospective study. | to determine the microbiota at implants and adjacent teeth 10 years after placement of implants with a sandblasted and acid-etched surface. | 2016 | 25827437 |
| occurrence of periodontal pathogens in ethnic groups from a native brazilian reservation. | the present study was designed to evaluate the occurrence of periodontal pathogens in the subgingival biofilm of 100 native brazilians living at the umutina indian reservation, mato grosso state, brazil. | 2015 | 25847068 |
| pseudomonas aeruginosa and periodontal pathogens in the oral cavity and lungs of cystic fibrosis patients: a case-control study. | cystic fibrosis (cf) is the most frequent lethal genetic disease in the caucasian population. lung destruction is the principal cause of death by chronic pseudomonas aeruginosa colonization. there is a high prevalence of oropharyngeal anaerobic bacteria in sputum of cf patients. this study was carried out due to the lack of results comparing subgingival periodontal pathogenic bacteria between the oral cavity and lungs in patients with cf in relation with p. aeruginosa presence. our first goal wa ... | 2015 | 25854483 |
| relationship between gingival inflammation and pregnancy. | an increase in the prevalence and severity of gingival inflammation during pregnancy has been reported since the 1960s. though the etiology is not fully known, it is believed that increasing plasma sex steroid hormone levels during pregnancy have a dramatic effect on the periodontium. current works of research have shown that estrogen and progesterone increasing during pregnancy are supposed to be responsible for gingivitis progression. this review is focused not only on epidemiological studies, ... | 2015 | 25873767 |
| bacterial profile of aggressive periodontitis in morocco: a cross-sectional study. | aggressive periodontitis (agp) is one of the most severe forms of periodontal diseases. in morocco, aggregatibacter actinomycetemcomitans has been strongly associated with agp, however limited knowledge is available about the implication of other periodontal pathogens in this entity. therefore, the main aim of this study was to evaluate the composition of the subgingival microbiota in moroccan patients with agp. | 2015 | 25888404 |
| functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis. | periodontitis is a polymicrobial biofilm-induced inflammatory disease that affects 743 million people worldwide. the current model to explain periodontitis progression proposes that changes in the relative abundance of members of the oral microbiome lead to dysbiosis in the host-microbiome crosstalk and then to inflammation and bone loss. using combined metagenome/metatranscriptome analysis of the subgingival microbiome in progressing and non-progressing sites, we have characterized the distinct ... | 2015 | 25918553 |
| quantitation of biofilm and planktonic life forms of coexisting periodontal species. | complexity of oral polymicrobial communities has prompted a need for developing in vitro models to study behavior of coexisting bacteria. little knowledge is available of in vitro co-growth of several periodontitis-associated species without early colonizers of dental plaque. | 2015 | 25926392 |
| increased infection with key periodontal pathogens during gestational diabetes mellitus. | gestational diabetes mellitus (gdm), gingivitis, infection with specific periodontal pathogens and systemic inflammation each increase the risk for poor pregnancy outcome. we set out to monitor the interactions of gingivitis and gdm with respect to oral infection and the systemic inflammatory burden. | 2015 | 25959628 |
| the epigenetic paradigm in periodontitis pathogenesis. | epigenome refers to "epi" meaning outside the "genome." epigenetics is the field of study of the epigenome. epigenetic modifications include changes in the promoter cpg islands, modifications of histone protein structure, posttranslational repression by micro-rna which contributes to the alteration of gene expression. epigenetics provides an understanding of the role of gene-environment interactions on disease phenotype especially in complex multifactorial diseases. periodontitis is a chronic in ... | 2015 | 26015662 |
| microbial dynamics during conversion from supragingival to subgingival biofilms in an in vitro model. | the development of dental caries and periodontal diseases result from distinct shifts in the microbiota of the tooth-associated biofilm. this in vitro study aimed to investigate changes in biofilm composition and structure, during the shift from a 'supragingival' aerobic profile to a 'subgingival' anaerobic profile. biofilms consisting of actinomyces oris, candida albicans, fusobacterium nucleatum, streptococcus oralis, streptococcus mutans and veillonella dispar were aerobically grown in saliva ... | 2016 | 26033167 |
| nodulation characterization and proteomic profiling of bradyrhizobium liaoningense ccbau05525 in response to water-soluble humic materials. | the lignite biodegradation procedure to produce water-soluble humic materials (wshm) with a penicillium stain was established by previous studies in our laboratory. this study researched the effects of wshm on the growth of bradyrhizobium liaoningense ccbau05525 and its nodulation on soybean. results showed that wshm enhanced the cell density of ccbau05525 in culture, and increased the nodule number, nodule fresh weight and nitrogenase activity of the inoculated soybean plants. then the chemical ... | 2015 | 26054030 |
| global epidemiology of campylobacter infection. | campylobacter jejuni infection is one of the most widespread infectious diseases of the last century. the incidence and prevalence of campylobacteriosis have increased in both developed and developing countries over the last 10 years. the dramatic increase in north america, europe, and australia is alarming, and data from parts of africa, asia, and the middle east indicate that campylobacteriosis is endemic in these areas, especially in children. in addition to c. jejuni, there is increasing rec ... | 2015 | 26062576 |
| the influence and role of microbial factors in autoimmune kidney diseases: a systematic review. | a better understanding of the pathophysiology of autoimmune disorders is desired to allow tailored interventions. despite increased scientific interest a direct pathogenic factor in autoimmune renal disease has been described only in a minority like membranous nephropathy or anca-associated vasculitis. nonetheless the initial step leading to the formation of these antibodies is still obscure. in this review we will focus on the possible role of microbial factors in this context. staphylococcus a ... | 2015 | 26078982 |
| periodontal bacteria and prediabetes prevalence in origins: the oral infections, glucose intolerance, and insulin resistance study. | periodontitis and type 2 diabetes mellitus are known to be associated. the relationship between periodontal microbiota and early diabetes risk has not been studied. we investigated the association between periodontal bacteria and prediabetes prevalence among diabetes-free adults. origins (the oral infections, glucose intolerance and insulin resistance study) cross sectionally enrolled 300 diabetes-free adults aged 20 to 55 y (mean ± sd, 34 ± 10 y; 77% female). prediabetes was defined as follows: ... | 2015 | 26082387 |
| association of periodontal disease and pre-term low birth weight infants. | the incidence of pre-term low birth weight still prevails in developed as well as developing countries though the numbers may vary. periodontitis is a chronic inflammatory process with multifactorial etiology and adversely affects the outcome of pregnancy which becomes a major public health problem. the association of periodontitis as risk factor for pre-term birth has been in extensive research in the past two decades when a number of studies investigated this relationship. however, definite co ... | 2014 | 26085737 |
| association of periodontal disease and pre-term low birth weight infants. | the incidence of pre-term low birth weight still prevails in developed as well as developing countries though the numbers may vary. periodontitis is a chronic inflammatory process with multifactorial etiology and adversely affects the outcome of pregnancy which becomes a major public health problem. the association of periodontitis as risk factor for pre-term birth has been in extensive research in the past two decades when a number of studies investigated this relationship. however, definite co ... | 2014 | 26085737 |
| a randomized trial of ethyl lauroyl arginate-containing mouthrinse in the control of gingivitis. | this 4-week, single-centre, randomized, examiner-blind, controlled study investigated the efficacy and safety of 0.15% ethyl lauroyl arginate (lae)-containing mouthrinse in adults with mild-to-moderate gingivitis. | 2015 | 26087864 |
| prevalence of eight putative periodontal pathogens in atherosclerotic plaque of coronary artery disease patients and comparing them with noncardiac subjects: a case-control study. | the study was aimed to assess the prevalence of periodontal pathogens namely tannerella forsythia (t.f), campylobacter rectus (c.r), eikenella corrodens (e.c), porphyromonas gingivalis (p.g), treponema denticola (t.d), prevotella nigrescens (p.n) ,aggregatibacter actinomycetemcomitans (a.a), p.g (fi ma gene) and prevotella intermedia (p.i), in the subgingival and the atheromatous plaque of patients with coronary artery disease (cad), and comparing them with the noncardiac subjects thereby indica ... | 2017 | 26096116 |
| the biofilm community-rebels with a cause. | oral biofilms are one of the most complex and diverse ecosystem developed by successive colonization of more than 600 bacterial taxa. development starts with the attachment of early colonizers such as actinomyces species and oral streptococci on the acquired pellicle and tooth enamel. these bacteria not only adhere to tooth surface but also interact with each other and lay foundation for attachment of bridging colonizer such as fusobacterium nucleatum followed by late colonizers including the re ... | 2015 | 26120510 |
| a biofilm pocket model to evaluate different non-surgical periodontal treatment modalities in terms of biofilm removal and reformation, surface alterations and attachment of periodontal ligament fibroblasts. | there is a lack of suitable in vitro models to evaluate various treatment modalities intending to remove subgingival bacterial biofilm. consequently, the aims of this in vitro-study were: a) to establish a pocket model enabling mechanical removal of biofilm and b) to evaluate repeated non-surgical periodontal treatment with respect to biofilm removal and reformation, surface alterations, tooth hard-substance-loss, and attachment of periodontal ligament (pdl) fibroblasts. | 2015 | 26121365 |
| the influence of smoking on the peri-implant microbiome. | smokers are at high risk for 2 bacterially driven oral diseases: peri-implant mucositis and peri-implantitis. therefore, the purpose of this investigation was to use a deep-sequencing approach to identify the effect of smoking on the peri-implant microbiome in states of health and disease. peri-implant biofilm samples were collected from 80 partially edentulous subjects with peri-implant health, peri-implant mucositis, and peri-implantitis. bacterial dna was isolated and 16s ribsomal rna gene li ... | 2015 | 26124222 |
| the oral bacterial communities of children with well-controlled hiv infection and without hiv infection. | the oral microbial community (microbiota) plays a critical role in human health and disease. alterations in the oral microbiota may be associated with disorders such as gingivitis, periodontitis, childhood caries, alveolar osteitis, oral candidiasis and endodontic infections. in the immunosuppressed population, the spectrum of potential oral disease is even broader, encompassing candidiasis, necrotizing gingivitis, parotid gland enlargement, kaposi's sarcoma, oral warts and other diseases. here, ... | 2015 | 26146997 |
| host response, malnutrition and oral diseases. part 1. | effective defense response of the body requires the proper nutritional and metabolic preparation and adequate energy expenditure. every pathological process with coexisting malnutrition is subject to an increased risk of failure and complications in medical treatment, which is a serious threat to human health and life. malnutrition, particularly protein-calorie malnutrition, is characterized by a decrease in resistance, particularly involving cellular immune deficiency, which in turn causes a si ... | 2014 | 26155172 |
| effects of hangeshashinto on growth of oral microorganisms. | oral mucositis (om) in cancer patients induced by chemotherapy or radiotherapy has a significant impact on quality of life, and causes considerable morbidity. oral microorganisms are likely to intensify the inflammatory process and aggravate the formation of ulcers. hangeshashinto (hst), a japanese kampo medicine, has been reported to be effective when used as a gargle for the treatment of om. to clarify the effects of hst on oral microorganisms, we assessed its antimicrobial activity against 27 ... | 2015 | 26170876 |
| tlr4, nod1 and nod2 mediate immune recognition of putative newly identified periodontal pathogens. | periodontitis is a polymicrobial inflammatory disease that results from the interaction between the oral microbiota and the host immunity. although the innate immune response is important for disease initiation and progression, the innate immune receptors that recognize both classical and putative periodontal pathogens that elicit an immune response have not been elucidated. by using the human oral microbe identification microarray (homim), we identified multiple predominant oral bacterial speci ... | 2016 | 26177212 |
| exploring salivary microbiota in aids patients with different periodontal statuses using 454 gs-flx titanium pyrosequencing. | patients with acquired immunodeficiency syndrome (aids) are at high risk of opportunistic infections. oral manifestations have been associated with the level of immunosuppression, these include periodontal diseases, and understanding the microbial populations in the oral cavity is crucial for clinical management. the aim of this study was to examine the salivary bacterial diversity in patients newly admitted to the aids ward of the public health clinical center (china). saliva samples were colle ... | 2015 | 26191508 |
| detection of subgingival periodontal pathogens--comparison of two sampling strategies. | the aim of the study is to compare detection frequency of periodontal pathogens in patients with aggressive/severe chronic periodontitis using pooled plaque samples from the deepest pockets per quadrant/per sextant. | 2016 | 26193958 |
| periodontal diseases: bug induced, host promoted. | 2015 | 26226364 | |
| periodontal health awareness among gynecologists in riyadh, saudi arabia. | to determine the knowledge of periodontal disease and pregnancy outcomes among the gynecologists practicing in riyadh, saudi arabia. | 2015 | 26236681 |
| microbiologic and clinical findings of implants in healthy condition and with peri-implantitis. | to compare implants in healthy conditions and implants with peri-implantitis with regard to their clinical parameters and the microbiologic composition at the peri-implant sulcus, inside the implant connection, and the gingival sulcus of neighboring teeth. | 2016 | 26252036 |
| the inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity. | inflammasomes are an oligomeric assembly of multiprotein complexes that activate the caspase-1-dependent maturation and the subsequent secretion of inflammatory interleukin-1beta and interleukin-18 cytokines in response to a 'danger signal' in vertebrates. the assessment of their significance continues to grow rapidly as the complex biology of various chronic inflammatory conditions is better dissected. increasing evidence strongly links inflammasomes and host-derived small 'danger molecule atp' ... | 2015 | 26252403 |
| long-term evaluation of the antimicrobial susceptibility and microbial profile of subgingival biofilms in individuals with aggressive periodontitis. | this study evaluates the antimicrobial susceptibility and composition of subgingival biofilms in generalized aggressive periodontitis (gap) patients treated using mechanical/antimicrobial therapies, including chlorhexidine (chx), amoxicillin (amx) and metronidazole (met). gap patients allocated to the placebo (c, n = 15) or test group (t, n = 16) received full-mouth disinfection with chx, scaling and root planning, and systemic amx (500 mg)/met (250 mg) or placebos. subgingival plaque samples we ... | 2015 | 26273264 |
| periodontal microbiota and phospholipases: the oral infections and vascular disease epidemiology study (invest). | periodontal infections have been linked to cardiovascular disease, including atherosclerosis, and systemic inflammation has been proposed as a possible mediator. secretory phospholipase a2 (s-pla2) and lipoprotein-associated pla2 (lp-pla2) are inflammatory enzymes associated with atherosclerosis. no data are available on the association between oral microbiota and pla2s. we studied whether a relationship exists between periodontal microbiota and the activities of these enzymes. | 2015 | 26282947 |
| synergic phototoxic effect of visible light or gallium-arsenide laser in the presence of different photo-sensitizers on porphyromonas gingivalis and fusobacterium nucleatum. | according to the development of resistant strains of pathogenic bacteria following treatment with antimicrobial chemotherapeutic agents, alternative approaches such as lethal photosensitization are being used. the aim of this study was to evaluate the effect of visible light and laser beam radiation in conjugation with three different photosensitizers on the survival of two main periodontopathogenic bacteria including porphyromonas gingivalis and fusobacterium nucleatum in different exposure per ... | 2015 | 26288621 |
| the expression of gingival epithelial junctions in response to subgingival biofilms. | periodontitis is an infectious inflammatory disease that destroys the tooth-supporting tissues. it is caused by the formation of subgingival biofilms on the surface of the tooth. characteristic bacteria associated with subgingival biofilms are the gram-negative anaerobes porphyromonas gingivalis, tannerella forsythia and treponema denticola, collectively known as the "red complex" species. inter-epithelial junctions ensure the barrier integrity of the gingival epithelium. this may however be dis ... | 2015 | 26305580 |
| oral campylobacter species: initiators of a subgroup of inflammatory bowel disease? | in recent years, a number of studies detected a significantly higher prevalence of campylobacter species such as campylobacter concisus (c. concisus) in intestinal biopsies and fecal samples collected from patients with inflammatory bowel disease (ibd) compared to controls. most of these campylobacter species are not of zoonotic origin but are human oral campylobacter species. bacterial species usually cause diseases in the location where they colonize. however, c. concisus and other oral campyl ... | 2015 | 26309350 |
| oxidative stress and igg antibody modify periodontitis-crp association. | in a previous report, we demonstrated the inverse association of high serum 8-isoprostane levels, a marker for oxidative stress, with decreased serum igg antibodies to oral bacteria. the association between increased serum igg with increased plaque and periodontitis (increased probing depths) was attenuated by high systemic oxidative stress. other investigations have reported a role for systemic oxidative stress as a stimulus of hepatic c-reactive protein (crp) response. these observations led u ... | 2015 | 26318589 |
| the effect of fixed orthodontic appliances and fluoride mouthwash on the oral microbiome of adolescents - a randomized controlled clinical trial. | while the aesthetic effect of orthodontic treatment is clear, the knowledge on how it influences the oral microbiota and the consequential effects on oral health are limited. in this randomized controlled clinical trial we investigated the changes introduced in the oral ecosystem, during and after orthodontic treatment with fixed appliances in combination with or without a fluoride mouthwash, of 10-16.8 year old individuals (n = 91). we followed several clinical parameters in time, in combinatio ... | 2015 | 26332408 |
| microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation. | the purpose of this study was to compare the microbial and clinical effects of mechanical debridement (md) alone or in combination with the application of enamel matrix derivative (emd) and sustained-release micro-spherical minocycline (msm) for treatment of peri-implant mucosal infl ammation (pimi). | 2015 | 26339576 |
| a randomized clinical trial of an adjunct diode laser application for the nonsurgical treatment of peri-implantitis. | in this radiographic and microbiologic split-mouth clinical trial, efficacy of a diode laser as an adjunct to conventional scaling in the nonsurgical treatment of peri-implantitis was investigated. | 2015 | 26382562 |
| systemic effects of periodontitis: lessons learned from research on atherosclerotic vascular disease and adverse pregnancy outcomes. | studies conducted over the past 25 years have focussed on the role of periodontitis, an inflammatory condition of microbial aetiology that destroys the tooth-supporting tissues, as a systemic inflammatory stressor that can act as an independent risk factor of atherosclerotic vascular disease (avsd) and adverse pregnancy outcomes (apos). it has been suggested that periodontitis-associated bacteraemias and systemic dissemination of inflammatory mediators produced in the periodontal tissues may res ... | 2015 | 26388299 |
| point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge. | periodontitis is a chronic inflammation of the periodontium caused by persistent bacterial infection that leads to the breakdown of connective tissue and bone. because the ability to reconstruct the periodontium is limited after alveolar bone loss, early diagnosis and intervention should be the primary goals of periodontal treatment. however, periodontitis often progresses without noticeable symptoms, and many patients do not seek professional dental care until the periodontal destruction progre ... | 2015 | 26389079 |
| effect of camphylobacter rectus on serum iron and transferrin- in-vivo findings. | periodontopathogens require iron constituents for their growth and metabolism in subgingival crevice. in this study, c.rectus was detected and quantified by using 16s rdna based pcr in chronic periodontitis and compared with the levels of serum iron, total iron binding capacity and transferrin in chronic periodontitis and healthy sites. | 2015 | 26393200 |
| in vitro culture of previously uncultured oral bacterial phylotypes. | around a third of oral bacteria cannot be grown using conventional bacteriological culture media. community profiling targeting 16s rrna and shotgun metagenomics methods have proved valuable in revealing the complexity of the oral bacterial community. studies investigating the role of oral bacteria in health and disease require phenotypic characterizations that are possible only with live cultures. the aim of this study was to develop novel culture media and use an in vitro biofilm model to cult ... | 2015 | 26407883 |
| should antibiotics be prescribed to treat chronic periodontitis? | although scaling and root planing is a cost-effective approach for initial treatment of chronic periodontitis, it fails to eliminate subgingival pathogens and halt progressive attachment loss in some patients. adjunctive use of systemic antibiotics immediately after completion of scaling and root planing can enhance the degree of clinical attachment gain and probing depth reduction provided by nonsurgical periodontal treatment. this article discusses the rationale for prescribing adjunctive anti ... | 2015 | 26427574 |
| pancreatic amylase is an environmental signal for regulation of biofilm formation and host interaction in campylobacter jejuni. | campylobacter jejuni is a commensal bacterium in the intestines of animals and birds and a major cause of food-borne gastroenteritis in humans worldwide. here we show that exposure to pancreatic amylase leads to secretion of an α-dextran by c. jejuni and that a secreted protease, cj0511, is required. exposure of c. jejuni to pancreatic amylase promotes biofilm formation in vitro, increases interaction with human epithelial cell lines, increases virulence in the galleria mellonella infection mode ... | 2015 | 26438798 |
| incorporation of staphylococci into titanium-grown biofilms: an in vitro "submucosal" biofilm model for peri-implantitis. | staphylococcus spp. are postulated to play a role in peri-implantitis. this study aimed to develop a "submucosal" in vitro biofilm model, by integrating two staphylococci into its composition. | 2015 | 26461083 |
| incorporation of staphylococci into titanium-grown biofilms: an in vitro "submucosal" biofilm model for peri-implantitis. | staphylococcus spp. are postulated to play a role in peri-implantitis. this study aimed to develop a "submucosal" in vitro biofilm model, by integrating two staphylococci into its composition. | 2015 | 26461083 |
| towards microbiome transplant as a therapy for periodontitis: an exploratory study of periodontitis microbial signature contrasted by oral health, caries and edentulism. | conventional periodontal therapy aims at controlling supra- and subgingival biofilms. although periodontal therapy was shown to improve periodontal health, it does not completely arrest the disease. almost all subjects compliant with periodontal maintenance continue to experience progressive clinical attachment loss and a fraction of them loses teeth. an oral microbial transplant may be a new alternative for treating periodontitis (inspired by fecal transplant). first, it must be established tha ... | 2015 | 26468081 |
| oral microbiota, periodontal status, and osteoporosis in postmenopausal females. | alterations in hormone levels during menopause decrease bone density and may worsen oral health, favoring the growth of periodontal pathogens, whose detection could improve the diagnosis of periodontitis. the aim of this study is to detect and quantify the main periodontal pathogens in the oral microbiota of postmenopausal females and to explore the relationship between clinical and periodontal parameters. | 2016 | 26469811 |
| toll-like receptors: a key marker for periodontal disease and preterm birth - a contemporary review. | the receptors of the innate immune system have evolved to recognize pathogenic bacteria in a complex manner. out of these immune receptors, the pattern recognition receptors (prrs) such as toll like receptors have gained importance off late to play a key role in the activation of cascade of inflammatory cytokines in pathogenesis of preterm birth. preterm birth has become leading cause of neonatal deaths globally. the concept of oral infection influencing the occurrence of preterm delivery has ga ... | 2015 | 26501032 |
| quantitative analysis of periodontal pathogens in periodontitis and gingivitis. | periodontal tissues surround the teeth and provide their attachment. periodontal diseases include a mild and reversible form named gingivitis and periodontitis that is the main cause of tooth loss in adults. gingivitis, that affects gums and coronal junctional epithelium, as well as periodontitis, that is characterized by loss of connective tissue attachment, are caused by a persistent inflammatory response promoted by alteration of periodontal biofilm. the aim of the study was to test whether t ... | 2017 | 26511188 |
| periodontal pathogens and risk of incident cancer in postmenopausal females: the buffalo osteoperio study. | extraoral translocation of oral bacteria may contribute to associations between periodontal disease and cancer. the associations among the presence of three orange-complex periodontal pathogens (fusobacterium nucleatum, prevotella intermedia, and campylobacter rectus), two red-complex periodontal pathogens (porphyromonas gingivalis and tannerella forsythia), and cancer risk were investigated. | 2016 | 26513268 |
| proteomic profiling of host-biofilm interactions in an oral infection model resembling the periodontal pocket. | periodontal infections cause inflammatory destruction of the tooth supporting tissues. we recently developed a dynamic, in vitro periodontal organotypic tissue model in a perfusion bioreactor system, in co-culture with an 11-species subgingival biofilm, which may recapitulate early events during the establishment of periodontal infections. this study aimed to characterize the global proteome regulations in this host-biofilm interaction model. semi-quantitative shotgun proteomics were applied for ... | 2015 | 26525412 |
| treatment alternatives to negotiate peri-implantitis. | peri-implant diseases are becoming a major health issue in dentistry. despite the magnitude of this problem and the potential grave consequences, commonly acceptable treatment protocols are missing. hence, the present paper reviews the literature treatment of peri-implantitis in order to explore their benefits and limitations. treatment of peri-implantitis may include surgical and nonsurgical approaches, either individually or combined. nonsurgical therapy is aimed at removing local irritants fr ... | 2014 | 26556414 |
| photodynamic therapy in the treatment of aggressive periodontitis: a systematic review. | aggressive periodontitis (agp) is a severe form of periodontal diseases with rapid destruction of the supporting bone around teeth. the efficacy of pdt in suppressing periodontal pathogens may be crucial in adopting new protocols for the treatment of agp. thus, the aim of this systematic review was to investigate the possible role of pdt in the treatment of agp as an adjunctive therapy or monotherapy. | 2015 | 26595837 |
| photodynamic therapy in the treatment of aggressive periodontitis: a systematic review. | aggressive periodontitis (agp) is a severe form of periodontal diseases with rapid destruction of the supporting bone around teeth. the efficacy of pdt in suppressing periodontal pathogens may be crucial in adopting new protocols for the treatment of agp. thus, the aim of this systematic review was to investigate the possible role of pdt in the treatment of agp as an adjunctive therapy or monotherapy. | 2015 | 26595837 |
| tlr expression profile of human gingival margin-derived stem progenitor cells. | gingival margin-derived stem/progenitor cells (g-mscs) show remarkable periodontal regenerative potential in vivo. during regeneration, g-mscs may interact with their inflammatory environment via toll-like-receptors (tlrs). the present study aimed to depict the g-mscs tlrs expression profile. | 2015 | 26615501 |
| tlr expression profile of human gingival margin-derived stem progenitor cells. | gingival margin-derived stem/progenitor cells (g-mscs) show remarkable periodontal regenerative potential in vivo. during regeneration, g-mscs may interact with their inflammatory environment via toll-like-receptors (tlrs). the present study aimed to depict the g-mscs tlrs expression profile. | 2015 | 26615501 |
| optimized use of the maldi biotyper system and the filmarray bcid panel for direct identification of microbial pathogens from positive blood cultures. | despite the current reliance on blood cultures (bcs), the diagnosis of bloodstream infections (bsis) can be sped up using new technologies performed directly on positive bc bottles. two methods (the maldi biotyper system and filmarray blood culture identification [bcid] panel) are potentially applicable. in this study, we performed a large-scale clinical evaluation (1,585 microorganisms from 1,394 bsi episodes) on the combined use of the maldi biotyper and filmarray bcid panel compared to a refe ... | 2016 | 26677254 |
| smrt sequencing of the campylobacter coli bfr-ca-9557 genome sequence reveals unique methylation motifs. | campylobacter species are the most prevalent bacterial pathogen causing acute enteritis worldwide. in contrast to campylobacter jejuni, about 5 % of campylobacter coli strains exhibit susceptibility to restriction endonuclease digestion by dpni cutting specifically 5'-g(m)atc-3' motifs. this indicates significant differences in dna methylation between both microbial species. the goal of the study was to analyze the methylome of a c. coli strain susceptible to dpni digestion, to identify its meth ... | 2015 | 26689587 |
| impact of denture cleaning method and overnight storage condition on denture biofilm mass and composition: a cross-over randomized clinical trial. | appropriate oral hygiene is required to maintain oral health in denture wearers. this study aims to compare the role of denture cleaning methods in combination with overnight storage conditions on biofilm mass and composition on acrylic removable dentures. | 2016 | 26730967 |
| porphyromonas gingivalis within placental villous mesenchyme and umbilical cord stroma is associated with adverse pregnancy outcome. | intrauterine presence of porphyromonas gingivalis (pg), a common oral pathobiont, is implicated in preterm birth. our aim was to determine if the location of pg within placental and/or umbilical cord sections was associated with a specific delivery diagnosis at preterm delivery (histologic chorioamnionitis, chorioamnionitis with funisitis, preeclampsia, and preeclampsia with hellp-syndrome, small for gestational age). the prevalence and location of pg within archived placental and umbilical cord ... | 2016 | 26731111 |
| life in a diverse oral community - strategies for oxidative stress survival. | while the oral cavity harbors more than 680 bacterial species, the interaction and association of selected bacterial species play a role in periodontal diseases. bacterial species including porphyromonas gingivalis, treponema denticola and tannerella forsythia, a consortium previously designated as the "red complex" is now being expanded to include other new emerging pathogens that are significantly associated with periodontal disease. | 2014 | 26744578 |
| identification of known and novel recurrent viral sequences in data from multiple patients and multiple cancers. | virus discovery from high throughput sequencing data often follows a bottom-up approach where taxonomic annotation takes place prior to association to disease. albeit effective in some cases, the approach fails to detect novel pathogens and remote variants not present in reference databases. we have developed a species independent pipeline that utilises sequence clustering for the identification of nucleotide sequences that co-occur across multiple sequencing data instances. we applied the workf ... | 2016 | 26907326 |
| comparison of the detection of periodontal pathogens in bacteraemia after tooth brushing by culture and molecular techniques. | the prevalence and amounts of periodontal pathogens detected in bacteraemia samples after tooth brushing-induced by means of four diagnostic technique, three based on culture and one in a molecular-based technique, have been compared in this study. | 2016 | 26946197 |
| genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease. | genome-wide association studies (gwas) of chronic periodontitis (cp) defined by clinical criteria alone have had modest success to-date. here, we refine the cp phenotype by supplementing clinical data with biological intermediates of microbial burden (levels of eight periodontal pathogens) and local inflammatory response (gingival crevicular fluid il-1β) and derive periodontal complex traits (pcts) via principal component analysis. pcts were carried forward to gwas (∼2.5 million markers) to iden ... | 2016 | 26962152 |
| management of diabolical diabetes mellitus and periodontitis nexus: are we doing enough? | periodontitis is the commonest oral disease affecting population worldwide. this disease is notorious for the devastation of tooth supporting structures, ensuing in the loss of dentition. the etiology for this disease is bacterial biofilm, which accumulates on the teeth as dental plaque. in addition to the biofilm microorganisms, other factors such as environmental, systemic and genetic are also responsible in progression of periodontitis. diabetes mellitus (dm) is metabolic disorder which has a ... | 2016 | 26962409 |
| are herpes virus associated to aggressive periodontitis? a review of literature. | periodontal disease includes a wide variety of infectious entities with various clinical manifestations in the oral cavity and responses to treatment. the determinants of clinical manifestations of periodontal disease include the type of infectious agent, the host immune response and environmental factors. aggressive periodontitis (ap) is defined as a type of inflammation with specific clinical and laboratory features, which distinguish it from other types of periodontitis, with high incidence r ... | 2015 | 26980964 |
| influence of type 2 diabetes on prevalence of key periodontal pathogens, salivary matrix metalloproteinases, and bone remodeling markers in sudanese adults with and without chronic periodontitis. | this study compared the influence of type 2 diabetes on the occurrence of six periodontal pathogens in plaque samples of patients with and without chronic periodontitis. levels of salivary mmp-8, mmp-9, rankl, and opg were also investigated. the study enrolled 31 patients with type 2 diabetes and chronic periodontitis (dm + cp), 29 with chronic periodontitis (cp), and 20 with type 2 diabetes (dm). questionnaire-guided interviews were conducted and plaque index, bleeding on probing, and pocket de ... | 2016 | 26989414 |
| accuracy of commercial kits and published primer pairs for the detection of periodontopathogens. | despite the input of microbiome research, a group of 20 bacteria continues to be the focus of periodontal diagnostics and therapy. the aim of this study was to compare three commercial kits and laboratory-developed primer pairs for effectiveness in detecting such periodontopathogens. | 2016 | 27020914 |
| non-inflammatory destructive periodontal disease. | non-inflammatory destructive periodontal disease (nidpd), is a severe destructive periodontal disease, that is characterized by the attachment loss and alveolar bone loss, without signs of the gingival inflammation, and the periodontal pocket development. | 2016 | 27053968 |
| periodontal pathogenic bacteria and ammp-8 findings depending on periodontal conditions of patients before and after liver transplantation. | the aim of this single-center cross-sectional study was to detect the prevalence of selected periodontal pathogenic bacteria and active matrix metalloproteinase-8 (ammp-8) level in patients before (preltx) and after liver transplantation (postltx). | 2017 | 27074844 |
| infectious and coronary artery disease. | atherosclerotic event is one of the most causes of death in the world. coronary artery disease (cad) is one manifestation of atherosclerosis. it is well-known that several risk factors, such as diabetes mellitus (dm), smoking, hypertension (htn), have effects on it. it is proposed that infection can lead to atherosclerosis or even make its process faster. here, we discuss about the effect of some of infectious agents on the atherosclerosis and cad. | 2016 | 27114736 |
| detection of cfxa2, cfxa3, and cfxa6 genes in beta-lactamase producing oral anaerobes. | purpose the aim of this study was to identify β-lactamase-producing oral anaerobic bacteria and screen them for the presence of cfxa and blatem genes that are responsible for β-lactamase production and resistance to β-lactam antibiotics. material and methods periodontal pocket debris samples were collected from 48 patients with chronic periodontitis and anaerobically cultured on blood agar plates with and without β-lactam antibiotics. presumptive β-lactamase-producing isolates were evaluated for ... | 2016 | 27119762 |
| polymerase chain reaction: a molecular diagnostic tool in periodontology. | this review discusses the principles of polymerase chain reaction (pcr) and its application as a diagnostic tool in periodontology. the relevant medline and pubmed indexed journals were searched manually and electronically by typing pcr, applications of pcr, pcr in periodontics, polymorphism studies in periodontitis, and molecular techniques in periodontology. the searches were limited to articles in english language and the articles describing pcr process and its relation to periodontology were ... | 2016 | 27143822 |
| effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis - a clinicobiochemical study. | the impact of simvastatin (smv), a cholesterol lowering drug, on bone metabolism appears to involve complex interaction with cholesterol metabolites, hormones, inflammatory mediators and growth factors, thus having direct influence on extent and severity of periodontitis. the present study aims to evaluate the in vivo effect of subgingivally delivered smv gel (1.2 mg) as a local drug-delivery agent on clinical parameters and on interleukin-6 (il-6), interleukin-8 (il-8) and interleukin-10 (il-10 ... | 2015 | 27195204 |
| effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis - a clinicobiochemical study. | the impact of simvastatin (smv), a cholesterol lowering drug, on bone metabolism appears to involve complex interaction with cholesterol metabolites, hormones, inflammatory mediators and growth factors, thus having direct influence on extent and severity of periodontitis. the present study aims to evaluate the in vivo effect of subgingivally delivered smv gel (1.2 mg) as a local drug-delivery agent on clinical parameters and on interleukin-6 (il-6), interleukin-8 (il-8) and interleukin-10 (il-10 ... | 2015 | 27195204 |
| periodontal disease's contribution to alzheimer's disease progression in down syndrome. | people with down syndrome (ds) are at an increased risk for alzheimer's disease (ad). after 60 years of age, >50% of ds subjects acquire dementia. nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. genetics cannot be modified, but environmental risk factors present a potentially relevant intervention for ds persons at risk for ad. among them, inflammation, important in ad of ds type, is potential target. consistent with this hypothesis, ... | 2016 | 27239536 |
| adjunctive use of essential oils following scaling and root planing -a randomized clinical trial. | hitherto no study has been published on the effect of the adjunctive administration of essential oils following scaling and root planing (srp). this study describes the effect of a mouthrinse consisting of essential oils (cymbopogon flexuosus, thymus zygis and rosmarinus officinalis) following srp by clinical and microbiological variables in patients with generalized moderate chronic periodontitis. | 2016 | 27266517 |
| microbial complexes levels in conventional and self-ligating brackets. | the aims were to evaluate the levels of bacterial species in saliva and in situ and to assess whether the design of brackets influences the risk of developing periodontal disease. | 2016 | 27270902 |
| novel immunomodulatory flagellin-like protein flac in campylobacter jejuni and other campylobacterales. | the human diarrheal pathogens campylobacter jejuni and campylobacter coli interfere with host innate immune signaling by different means, and their flagellins, flaa and flab, have a low intrinsic property to activate the innate immune receptor toll-like receptor 5 (tlr5). we have investigated here the hypothesis that the unusual secreted, flagellin-like molecule flac present in c. jejuni, c. coli, and other campylobacterales might activate cells via tlr5 and interact with tlr5. flac shows striki ... | 2015 | 27303676 |
| novel immunomodulatory flagellin-like protein flac in campylobacter jejuni and other campylobacterales. | the human diarrheal pathogens campylobacter jejuni and campylobacter coli interfere with host innate immune signaling by different means, and their flagellins, flaa and flab, have a low intrinsic property to activate the innate immune receptor toll-like receptor 5 (tlr5). we have investigated here the hypothesis that the unusual secreted, flagellin-like molecule flac present in c. jejuni, c. coli, and other campylobacterales might activate cells via tlr5 and interact with tlr5. flac shows striki ... | 2015 | 27303676 |
| nonsyndromic localized aggressive periodontitis of primary dentition: a rare case report. | periodontitis is an inflammatory disease of the gingiva and tissues of the periodontium. it is characterized by pocket formation and destruction of supporting alveolar bone. periodontal diseases of aggressive nature are not very common in children. they are usually associated with systemic conditions. the present case report is of a 5-year-old male child who reported with rapid attachment loss and bony defects of the gingiva and supporting structures. his family and medical history gave no contr ... | 2016 | 27307682 |
| quantitative molecular detection of 19 major pathogens in the interdental biofilm of periodontally healthy young adults. | in oral health, the interdental spaces are a real ecological niche for which the body has few or no alternative defenses and where the traditional daily methods for control by disrupting biofilm are not adequate. the interdental spaces are the source of many hypotheses regarding their potential associations with and/or causes of cardiovascular disease, diabetes, chronic kidney disease, degenerative disease, and depression. this pcr study is the first to describe the interdental microbiota in hea ... | 2016 | 27313576 |