Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| strong country level correlation between syphilis and hsv-2 prevalence. | background. syphilis is curable but herpes simplex virus-2 (hsv-2) is not. as a result, the prevalence of syphilis but not hsv-2 may be influenced by the efficacy of national sti screening and treatment capacity. if the prevalence of syphilis and hsv-2 is found to be correlated, then this makes it more likely that something other than differential sti treatment is responsible for variations in the prevalence of both hsv-2 and syphilis. methods. simple linear regression was used to evaluate the r ... | 2016 | 27069710 |
| managing atypical and typical herpetic central nervous system infections: results of a multinational study. | there have been many studies pertaining to the management of herpetic meningoencephalitis (hme), but the majority of them have focussed on virologically unconfirmed cases or included only small sample sizes. we have conducted a multicentre study aimed at providing management strategies for hme. overall, 501 adult patients with pcr-proven hme were included retrospectively from 35 referral centres in 10 countries; 496 patients were found to be eligible for the analysis. cerebrospinal fluid (csf) a ... | 2016 | 27085724 |
| [immune system data in patients with persistent recurent herpes virus infections in dynamics of complex therapy]. | the positive clinical, serolgical and immunological effects of glutamyl-triptophan in patients on persistent herpes virus infections are shown. treatment resulted in the increase of avidity on hsv 1, hsv 2, cmv, ebv antibody, the levels of cd3+-, icd8+-, cd16+-, cd3+hla-dr+- (%, abs) and.cd3+cd25t-cells (%), that indicates the optimization of the immune systemdata. the data received allow to recommend bestim for patients with persistent herpes virus infections. | 2016 | 27089710 |
| implementation and evaluation of a fully automated multiplex real-time pcr assay on the bd max platform to detect and differentiate herpesviridae from cerebrospinal fluids. | a fully automated multiplex real-time pcr assay--including a sample process control and a plasmid based positive control--for the detection and differentiation of herpes simplex virus 1 (hsv1), herpes simplex virus 2 (hsv2) and varicella-zoster virus (vzv) from cerebrospinal fluids (csf) was developed on the bd max platform. performance was compared to an established accredited multiplex real time pcr protocol utilizing the easymag and the lightcycler 480/ii, both very common devices in viral mo ... | 2016 | 27092772 |
| polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus. | twelve polyhydroxylated sulfated steroids synthesized from a 5α-cholestane skeleton with different substitutions in c-2, c-3 and c-6 were evaluated for cytotoxicity and antiviral activity against herpes simplex virus (hsv) by a virus plaque reduction assay. four compounds elicited a selective inhibitory effect against hsv. the disodium salt of 2β,3α-dihydroxy-6e-hydroximine-5α-cholestane-2,3-disulfate, named compound 7, was the most effective inhibitor of hsv-1, hsv-2 and pseudorabies virus (prv ... | 2016 | 27101075 |
| correlating flavivirus virulence and levels of intrinsic disorder in shell proteins: protective roles vs. immune evasion. | computational analyses revealed correlations between the intrinsic disorder propensity of shell proteins and case fatality rates (cfrs) among flaviviruses and within at least two flavivirus species, such as tick-borne encephalitis virus (tbev) and dengue virus (denv). the shell proteins analyzed in this study are capsid (c) and membrane (prm, pr, and m) proteins. the highest correlations can be found when regression analyses were conducted using pr (flavivirus: r(2) = 0.78, p < 0.01) or m (flavi ... | 2016 | 27102744 |
| vaccination with the secreted glycoprotein g of herpes simplex virus 2 induces protective immunity after genital infection. | herpes simplex virus 2 (hsv-2) infects the genital mucosa and establishes a life-long infection in sensory ganglia. after primary infection hsv-2 may reactivate causing recurrent genital ulcerations. hsv-2 infection is prevalent, and globally more than 400 million individuals are infected. as clinical trials have failed to show protection against hsv-2 infection, new vaccine candidates are warranted. the secreted glycoprotein g (sgg-2) of hsv-2 was evaluated as a prophylactic vaccine in mice usi ... | 2016 | 27110813 |
| herpes simplex vaccines: prospects of live-attenuated hsv vaccines to combat genital and ocular infections. | herpes simplex virus type-1 (hsv-1) and its closely related type-2 (hsv-2) viruses cause important clinical manifestations in humans including acute ocular disease and genital infections. these viruses establish latency in the trigeminal ganglionic and dorsal root neurons, respectively. both viruses are widespread among humans and can frequently reactivate from latency causing disease. currently, there are no vaccines available against herpes simplex viral infections. however, a number of promis ... | 2015 | 27114893 |
| in situ detection of regulatory t cells in human genital herpes simplex virus type 2 (hsv-2) reactivation and their influence on spontaneous hsv-2 reactivation. | herpes simplex virus type 2 (hsv-2) reactivation is accompanied by a sustained influx of cd4(+) and cd8(+) t cells that persist in genital tissue for extended periods. while cd4(+) t cells have long been recognized as being present in herpetic ulcerations, their role in subclinical reactivation and persistence is less well known, especially the role of cd4(+) regulatory t cells (tregs). | 2016 | 27117511 |
| high prevalence of herpes simplex virus (hsv)- type 2 co-infection among hiv-positive women in ukraine, but no increased hiv mother-to-child transmission risk. | over 3500 hiv-positive women give birth annually in ukraine, a setting with high prevalence of sexually transmitted infections. herpes simplex virus type 2 (hsv-2) co-infection may increase hiv mother-to-child transmission (mtct) risk. we explored factors associated with hsv-2 seropositivity among hiv-positive women in ukraine, and its impact on hiv mtct. | 2016 | 27121953 |
| effects of a traditional chinese medicine, longdanxiegan formula granule, on toll-like receptor pathway in female guinea pigs with recurrent genital herpes. | the aim of the present study was to investigate the effects of longdanxiegan formula granule (ldxgfg), a chinese traditional medicine on toll-like receptor (tlr) pathway in recurrent genital herpes. | 2016 | 27125405 |
| statistical analysis of amenamevir (asp2151) between pharmacokinetics and clinical efficacies with non-linear effect model for the treatment of genital herpes. | amenamevir is the international non-proprietary name for asp2151 synthesized by astellas pharma, inc. it is a structurally novel class of helicase-primase inhibitor and demonstrated more potency in vitro anti-viral activity with low cytotoxicity against varicella-zoster virus (vzv), herpes simplex virus type 1 (hsv-1), and herpes simplex virus type 2 (hsv-2) than acyclovir (acv). phase ii randomized trial assessed the safety and efficacy of asp2151 for episodic therapy of recurrent genital herpe ... | 2014 | 27129009 |
| herpesvirus infections and risk of frailty and mortality in older women: women's health and aging studies. | to examine the relationship between herpesvirus infections and mortality and incident frailty risks in community-dwelling older women. | 2016 | 27131018 |
| prevalence of intrathecal acyclovir resistant virus in herpes simplex encephalitis patients. | herpes simplex encephalitis (hse) is a life-threatening complication of herpes simplex virus (hsv) infection. acyclovir (acv) is the antiviral treatment of choice, but may lead to emergence of acv-resistant (acvr) hsv due to mutations in the viral ul23 gene encoding for the acv-targeted thymidine kinase (tk) protein. here, we determined the prevalence of intrathecal acvr-associated hsv tk mutations in hse patients and compared tk genotypes of sequential hsv isolates in paired cerebrospinal fluid ... | 2016 | 27171421 |
| evaluation of a transcription mediated amplification assay for detection of herpes simplex virus types 1 and 2 mrna in clinical specimens. | herpes simplex viruses (hsv) are double-stranded dna human herpesviruses (hhvs) that have the capacity to cause significant morbidity and mortality in humans. like hhv5 (cytomegalovirus) and hhv8 (kaposi's sarcoma virus), hsv type 1 (hsv-1), and hsv type 2 (hsv-2) (hhv1, hhv2) selectively package certain viral messenger rnas inside mature virions, as well as expressing those mrnas in infected cells. | 2016 | 27175478 |
| self-collected genital swabs compared with cervicovaginal lavage for measuring hiv-1 and hsv-2 and the effect of acyclovir on viral shedding. | hiv-1 and hsv-2 are frequent genital co-infections in women. to determine how self-collected genital swabs compare to provider-collected cervicovaginal lavage, paired self-collected genital swabs and cervicovaginal lavage from women co-infected with hiv-1 and hsv-2 were evaluated. women were in an acyclovir clinical trial and their samples were tested for hiv-1 rna (361 samples) and hsv-2 dna (378 samples). virus shedding, quantity and acyclovir effect were compared. hiv-1 and hsv-2 were more fr ... | 2017 | 27179350 |
| intravaginal zinc oxide tetrapod nanoparticles as novel immunoprotective agents against genital herpes. | virtually all efforts to generate an effective protection against the life-long, recurrent genital infections caused by hsv-2 have failed. apart from sexual transmission, the virus can also be transmitted from mothers to neonates, and it is a key facilitator of hiv coacquisition. in this article, we uncover a nanoimmunotherapy using specially designed zinc oxide tetrapod nanoparticles (zoten) with engineered oxygen vacancies. we demonstrate that zoten, when used intravaginally as a microbicide, ... | 2016 | 27183601 |
| performance of the hsv oligogen kit for the diagnosis of herpes simplex virus type 1 and 2. | pcr methods are nowadays between the most rapid and sensitive methods for screening and diagnosing herpes simplex virus (hsv) type 1 and 2. the aim of this study was to analyze the reliability, accuracy, and usefulness of the new assay hsv oligogen kit in comparison with the roche lightcycler hsv ½ qual kit assay for the detection of hsv in clinical samples. for this analysis, a prospective study was designed for detection of hsv-1 and hsv-2 including 110 ulcer specimens, 48 urine, 48 endocervic ... | 2016 | 27185644 |
| herpes simplex virus type 2 seroprevalence and ultrasound-diagnosed uterine fibroids in a large population of young african-american women. | for decades reproductive tract infections (rtis) have been hypothesized to play a role in uterine fibroid development. the few previous studies conducted used self-reported history of rtis and had inconsistent findings. we investigated this hypothesis further using serological analysis, an immunological measure of past exposure. we focused on herpes simplex virus type 2 (hsv-2) because prior published data have suggested a possible association with fibroids, and serology for hsv-2 is much more s ... | 2016 | 27188945 |
| immunological signaling during herpes simplex virus-2 and cytomegalovirus vaginal shedding after initiation of antiretroviral treatment. | vaginal proinflammatory cytokine expression during herpes virus reactivation was examined in human immunodeficiency virus-infected women before and after initiation of antiretroviral therapy (art). vaginal swabs were screened for levels of cytokines interleukin (il)-1β, il-2, il-4, il-6, il-8, il-10, il-12p70, il-13, tumor necrosis factor (tnf)-α, and interferon-γ. the relative risk (rr) of herpes simplex virus-2 or cytomegalovirus (cmv) shedding being associated with cytokine levels above the m ... | 2016 | 27191006 |
| development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways. | since their inception five decades ago, most antivirals have been engineered to disrupt a single viral protein or process that is essential for viral replication. this approach has limited the overall therapeutic effectiveness and applicability of current antivirals due to restricted viral specificity, a propensity for development of drug resistance, and an inability to control deleterious host-mediated inflammation. as obligate intracellular parasites, viruses are reliant on host metabolism and ... | 2016 | 27192555 |
| multicenter evaluation of meridian bioscience hsv 1&2 molecular assay for detection of herpes simplex virus 1 and 2 from clinical cutaneous and mucocutaneous specimens. | herpes simplex virus (hsv) causes acute and relapsing symptoms characterized by ulcerative lesions. laboratory diagnosis of hsv in cutaneous or mucocutaneous lesions has historically been performed with the use of viral cell culture systems; however, these tests are laborious and suffer decreased sensitivity for advanced-stage lesions. the recent availability of fda-cleared moderately complex assays has resulted in the increased use of molecular diagnostics for the routine detection of hsv in su ... | 2016 | 27194690 |
| herpes simplex virus-2 esophagitis in a young immunocompetent adult. | herpes simplex esophagitis (hse) is commonly identified in immunosuppressed patients. it is rare among immunocompetent patients and almost all of the reported cases are due to hsv-1 infection. hsv-2 esophagitis is extremely rare. we report the case of a young immunocompetent male who presented with dysphagia, odynophagia, and epigastric pain. endoscopy showed multitudes of white nummular lesions in the distal esophagus initially suspected to be candida esophagitis. however, classic histopatholog ... | 2016 | 27195158 |
| herpes simplex virus type 1 and type 2 infection increases atherosclerosis risk: evidence based on a meta-analysis. | objective. the aim of our study was to evaluate the relation of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) infection with the risk of atherosclerosis (as). methods. a systematic literature search was performed through three electronic databases. the pooled odds ratio (or) and corresponding 95% confidence interval (ci) were used to assess the effect of hsv-1 and hsv-2 infection on as risk. results. 17 studies were available for meta-analysis of hsv-1 infection and as risk and seven st ... | 2016 | 27195284 |
| formative work and community engagement approaches for implementing an hiv intervention in botswana schools. | providing adolescents with evidence-based sexual risk reduction interventions is critical to addressing the hiv/aids epidemic among adolescents in sub-saharan africa. project aim (adult identity mentoring) is an innovative, evidence-based, youth development intervention that is being evaluated for the first time in botswana through a 3-year (2015-2017), 50-school cluster randomized controlled trial, including testing for herpes simplex virus type 2 as a sexual activity biomarker. conducting a tr ... | 2016 | 27196663 |
| herpes simplex virus type 2: cluster of unrelated cases in an intensive care unit. | herpes simplex viruses, which are associated with various clinical manifestations, can be transmitted to critically ill patients from other patients or health care staff. we report an apparent outbreak of mucocutaneous herpes simplex virus 2 infections (5 cases in 10 weeks). an epidemiologic investigation and genotype analysis showed no connections among the 5 cases. | 2016 | 27198455 |
| access of protective antiviral antibody to neuronal tissues requires cd4 t-cell help. | circulating antibodies can access most tissues to mediate surveillance and elimination of invading pathogens. immunoprivileged tissues such as the brain and the peripheral nervous system are shielded from plasma proteins by the blood-brain barrier and blood-nerve barrier, respectively. yet, circulating antibodies must somehow gain access to these tissues to mediate their antimicrobial functions. here we examine the mechanism by which antibodies gain access to neuronal tissues to control infectio ... | 2016 | 27225131 |
| herpes simplex acute retinal necrosis presenting as unilateral disc swelling in young immunocompetent patients. | to report two cases of young immunocompetent males with herpes simplex acute retinal necrosis (hsv arn) with initial diagnosis of unilateral disc swelling. | 2016 | 27230575 |
| parallel declines in hiv and hepatitis c virus prevalence, but not in herpes simplex virus type 2 infection: a 10-year, serial cross-sectional study in an inner-city emergency department. | the johns hopkins hospital emergency department (jhhed) has served as an observational window on the hiv epidemic in a socioeconomically depressed, urban population. we previously reported that hiv incidence among jhhed patients is decreasing and that prevalence has declined from 11.4% in 2003-5.6% in 2013. | 2016 | 27232485 |
| clinical and corneal microbial profile of infectious keratitis in a high hiv prevalence setting in rural south africa. | the purpose of this investigation was to determine the clinical and corneal microbial profile of infectious keratitis in a high human immunodeficiency virus (hiv) prevalence setting in rural south africa. data in this cross-sectional study were collected from patients presenting with symptoms of infectious keratitis (n = 46) at the ophthalmology outpatient department of three hospitals in rural south africa. corneal swabs were tested for herpes simplex virus type 1 (hsv-1) and 2 (hsv-2), varicel ... | 2016 | 27236644 |
| high rates of herpes simplex virus type 2 infection in homeless women: informing public health strategies. | homeless and unstably housed women living in an urban setting are at risk for sexually transmitted diseases, yet the seroprevalence and correlates of herpes simplex virus type 2 (hsv-2) specific to impoverished women are poorly understood. | 2016 | 27243474 |
| prevalence and risk factors of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis and other sexually transmissible infections among women attending antenatal clinics in three provinces in papua new guinea: a cross-sectional survey. | background: papua new guinea (png) is estimated to have among the highest prevalences of hiv and sexually transmissible infections (stis) of any asia-pacific country, and one of the highest burdens of maternal syphilis globally. the prevalence of curable stis, such as chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv), among pregnant women in png is relatively unknown. methods: a cross-sectional bio-behavioural survey to investigate the epidemiology of ct, ng, ... | 2016 | 27248708 |
| development of a high-throughput β-gal-based neutralization assay for quantitation of herpes simplex virus-neutralizing antibodies in human samples. | measurement of neutralizing antibodies against herpes simplex virus (hsv) is important for evaluation of candidate vaccines. the established plaque-reduction neutralization assay is time consuming, labor intensive, and difficult to validate and transfer. here, we describe the characterization of a hsv-neutralization assay based on the expression of a reporter gene, β-galactosidase (β-gal). using previously constructed hsv-β-gal recombinant viruses, hsv-2/gal and hsv-1/tk12, we developed a colori ... | 2016 | 27265458 |
| the role of micrornas in the pathogenesis of herpesvirus infection. | micrornas (mirnas) are small non-coding rnas important in gene regulation. they are able to regulate mrna translation through base-pair complementarity. cellular mirnas have been involved in the regulation of nearly all cellular pathways, and their deregulation has been associated with several diseases such as cancer. given the importance of micrornas to cell homeostasis, it is no surprise that viruses have evolved to take advantage of this cellular pathway. viruses have been reported to be able ... | 2016 | 27271654 |
| exocytosis of alphaherpesvirus virions, light particles, and glycoproteins uses constitutive secretory mechanisms. | many molecular and cell biological details of the alphaherpesvirus assembly and egress pathway remain unclear. recently we developed a live-cell fluorescence microscopy assay of pseudorabies virus (prv) exocytosis, based on total internal reflection fluorescence (tirf) microscopy and a virus-encoded ph-sensitive fluorescent probe. here, we use this assay to distinguish three classes of viral exocytosis in a nonpolarized cell type: (i) trafficking of viral glycoproteins to the plasma membrane, (i ... | 2016 | 27273828 |
| prevention of vaginal and rectal herpes simplex virus type 2 transmission in mice: mechanism of antiviral action. | topical microbicides to stop sexually transmitted diseases, such as herpes simplex virus type 2 (hsv-2), are urgently needed. the emerging field of nanotechnology offers novel suitable tools for addressing this challenge. our objective was to study, in vitro and in vivo, antiherpetic effect and antiviral mechanisms of several polyanionic carbosilane dendrimers with anti-hiv-1 activity to establish new potential microbicide candidates against sexually transmitted diseases. plaque reduction assay ... | 2016 | 27274240 |
| genital herpes: a review. | genital herpes is a common sexually transmitted disease, affecting more than 400 million persons worldwide. it is caused by herpes simplex virus (hsv) and characterized by lifelong infection and periodic reactivation. a visible outbreak consists of single or clustered vesicles on the genitalia, perineum, buttocks, upper thighs, or perianal areas that ulcerate before resolving. symptoms of primary infection may include malaise, fever, or localized adenopathy. subsequent outbreaks, caused by react ... | 2016 | 27281837 |
| mathematical modeling predicts that increased hsv-2 shedding in hiv-1 infected persons is due to poor immunologic control in ganglia and genital mucosa. | a signature feature of hiv infection is poor control of herpes virus infections, which reactivate from latency and cause opportunistic infections. while the general mechanism underlying this observation is deficient cd4+t-cell function, it is unknown whether increased severity of herpes virus infections is due primarily to poor immune control in latent or lytic sites of infection, or whether cd4+ immunodeficiency leads to more critical downstream deficits in humoral or cell-mediated immunologic ... | 2016 | 27285483 |
| development and application of a rapid detection system for human papillomavirus and herpes simplex virus-2 by loop-mediated isothermal amplification assay. | human papillomavirus (hpv) infection is an important factor that causes cervical cancer and non-melanoma skin cancer (nmsc), while hsv-2 plays an important role when hr-hpv triggers the cancer. thus, a quick and convenient assay in the detection of hpv and hsv-2in the screening of hpv and hsv-2 infection is required. two respective hpv and hsv-2 detection methods were established based on loop-mediated isothermal amplification (lamp) assay. specific outer primers, inner primers, and loop primers ... | 2016 | 27287497 |
| antiviral activity of myticin c peptide from mussel: an ancient defense against herpesviruses. | little is known about the antiviral response in mollusks. as in other invertebrates, the interferon signaling pathways have not been identified, and in fact, there is a debate about whether invertebrates possess antiviral immunity similar to that of vertebrates. in marine bivalves, due to their filtering activity, interaction with putative pathogens, including viruses, is very high, suggesting that they should have mechanisms to address these infections. in this study, we confirmed that constitu ... | 2016 | 27307570 |
| csf herpes virus and autoantibody profiles in the evaluation of encephalitis. | to report the frequency of coexisting herpes viruses (herpes simplex virus 1 [hsv-1] or hsv-2, varicella zoster virus, epstein-barr virus [ebv], cytomegalovirus, or human herpes virus 6 [hhv-6]) and autoantibodies in patients with encephalitis (herpes or autoimmune) in clinical laboratory service. | 2016 | 27308306 |
| inhibition of herpes simplex type 1 and type 2 infections by oximacro(®), a cranberry extract with a high content of a-type proanthocyanidins (pacs-a). | in the absence of efficient preventive vaccines, topical microbicides offer an attractive alternative in the prevention of herpes simplex type 1 (hsv-1) and type 2 (hsv-2) infections. because of their recognized anti-adhesive activity against bacterial pathogens, cranberry (vaccinium macrocarpon ait.) extracts may represent a natural source of new antiviral microbicides. however, few studies have addressed the applications of cranberry extract as a direct-acting antiviral agent. here, we report ... | 2016 | 27321663 |
| common infections with polyomaviruses and herpesviruses and neuropsychological development at 4 years of age, the rhea birth cohort in crete, greece. | viral infections of the central nervous system may have detrimental effects for the developing brain, but the effects of less virulent common infections are unclear. we aim to investigate the impact of common viral infections of early childhood on neuropsychological performance of children at age four. | 2016 | 27334233 |
| herpes simplex virus 2 virion host shutoff endoribonuclease activity is required to disrupt stress granule formation. | we previously established that cells infected with herpes simplex virus 2 (hsv-2) are disrupted in their ability to form stress granules (sgs) in response to oxidative stress and that this disruption is mediated by virion host shutoff protein (vhs), a virion-associated endoribonuclease. here, we test the requirement for vhs endoribonuclease activity in disruption of sg formation. we analyzed the ability of hsv-2 vhs carrying the point mutation d215n, which ablates its endoribonuclease activity, ... | 2016 | 27334584 |
| the association between antibodies to neurotropic pathogens and schizophrenia: a case-control study. | exposure to neurotropic pathogens has been proposed as an environmental risk factor for schizophrenia and can be evaluated by measuring pathogen-specific immunoglobulin g (igg). seroprevalence of pathogen-specific igg reflects prior exposure, whereas igg levels are associated with reactivity or reinfection. several studies have examined these parameters in schizophrenia. however, results still remain inconclusive, as several previous studies did not correct for important confounding factors. | 2015 | 27336045 |
| a recombinant plasmid containing cpg motifs as a novel vaccine adjuvant for immune protection against herpes simplex virus 2. | the aim of the present study was to evaluate the efficacy of a herpes simplex virus type 2 (hsv-2) dna vaccine co‑immunized with a plasmid adjuvant containing cpg motifs. a novel eukaryotic expression plasmid vector containing kanamycin resistance gene (pcdna3kan) was acquired from pet‑28a(+) and pcdna3 plasmids. a gene encoding full length hsv‑2 glycoprotein d (gd) was amplified from the pcdna3‑gd plasmid, which was cloned into pcdna3kan resulting in the construction of the recombinant plasmid ... | 2016 | 27357208 |
| crispr/cas9-mediated genome editing of herpesviruses limits productive and latent infections. | herpesviruses infect the majority of the human population and can cause significant morbidity and mortality. herpes simplex virus (hsv) type 1 causes cold sores and herpes simplex keratitis, whereas hsv-2 is responsible for genital herpes. human cytomegalovirus (hcmv) is the most common viral cause of congenital defects and is responsible for serious disease in immuno-compromised individuals. epstein-barr virus (ebv) is associated with infectious mononucleosis and a broad range of malignancies, ... | 2016 | 27362483 |
| virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex pcr assay. | several studies have indicated that viral reactivations following allogeneic hematopoietic stem cell transplantation (allo-hsct) are frequent, but viral reactivations after autologous hsct (auto-hsct) have not been investigated in detail. we performed multiplex polymerase chain reaction (pcr) assay to examine multiple viral reactivations simultaneously in 24 patients undergoing auto-hsct between september 2010 and december 2012. weekly whole blood samples were collected from pre- to 42 days post ... | 2017 | 27364410 |
| increased expression of herpes virus-encoded hsv1-mir-h18 and hsv2-mir-h9-5p in cancer-containing prostate tissue compared to that in benign prostate hyperplasia tissue. | previously, we reported the presence of virus-encoded micrornas (mirnas) in the urine of prostate cancer (cap) patients. in this study, we investigated the expression of two herpes virus-encoded mirnas in prostate tissue. | 2016 | 27377944 |
| in vitro exposure to pc-1005 and cervicovaginal lavage fluid from women vaginally administered pc-1005 inhibits hiv-1 and hsv-2 infection in human cervical mucosa. | our recent phase 1 trial demonstrated that pc-1005 gel containing 50 μm miv-150, 14 mm zinc acetate dihydrate, and carrageenan (cg) applied daily vaginally for 14 days is safe and well tolerated. importantly, cervicovaginal lavage fluid samples (cvls) collected 4 or 24 h after the last gel application inhibited hiv-1 and human papillomavirus (hpv) in cell-based assays in a dose-dependent manner (miv-150 for hiv-1 and cg for hpv). herein we aimed to determine the anti-hiv and anti-herpes simplex ... | 2016 | 27381393 |
| prevalence of sexually transmitted viral and bacterial infections in hiv-positive and hiv-negative men who have sex with men in toronto. | hepatitis b (hbv), hepatitis c (hcv) and other sexually transmitted infections (stis) have been associated with hiv transmission risk and disease progression among gay men and other men who have sex with men (msm), but the frequency and distribution of stis in this community in canada has not been extensively studied. | 2016 | 27391265 |
| antiherpetic plants: a review of active extracts, isolated compounds, and bioassays. | herpes simplex is a disease that is widely distributed throughout the world. it is caused by herpes simplex virus type 1 (hsv-1) and simplex virus type 2 (hsv-2). the drugs of choice for treatment are acyclovir (acv), penciclovir (pcv) and other guanine analogues, which have the same mechanism of action. however, due to the constant increase of acv-resistant strains in immunocompromised patients, it is necessary to find new treatment alternatives. it has been shown that natural products are a go ... | 2016 | 27396217 |
| etiology of genital ulcer disease in male patients attending a sexually transmitted diseases clinic: first assessment in cuba. | sexually transmitted diseases (stds) and in particular genital ulcer disease (gud) have a major impact on morbidity and mortality in developing countries. the world health organization recommends the use of syndromic guidelines for the treatment of sexually transmitted infections (stis) in resource-constrained countries. surveillance of autochthonous etiologies provides epidemiological information contributing to the prevention and treatment of stis. we investigated the etiology and factors asso ... | 2016 | 27419816 |
| 3,19-isopropylideneandrographolide suppresses early gene expression of drug-resistant and wild type herpes simplex viruses. | a diterpenoid lactone, 3,19-isopropylideneandrographolide (ipad) compound isolated from andrographis paniculata (burm. f.) nees, has been reported to inhibit herpes simplex virus type 1 (hsv-1) infection at the post-entry step. to identify the molecular target of ipad, this study characterized the inhibitory effect of ipad on infection of vero cells by hsv-1, hsv-2 and a drug-resistant (dr) hsv-1 strain acgr4 (acyclovir-resistant and thymidine kinase (tk)-deficient). viral production, gene and p ... | 2016 | 27424493 |
| herpes simplex encephalitis: an uncommon presentation. | herpes simplex virus (hsv) encephalitis is an uncommon illness, with about 2 cases per 250,000 per year. most are caused by hsv-1, with 10% having hsv-2 as the aetiologic factor. we present a case of herpes simplex type1encephalitis in a 70 year old male with an uncommon presentation. the patient was a known case of endogenous depression with no medical records and on no treatment for the same, reported with acute changes in mental state for the past five days. he was talking irrelevantly, had h ... | 2016 | 27437286 |
| first-in-human trial of miv-150 and zinc acetate coformulated in a carrageenan gel: safety, pharmacokinetics, acceptability, adherence, and pharmacodynamics. | to evaluate the safety and pharmacokinetics of miv-150 and zinc acetate in a carrageenan gel (pc-1005). acceptability, adherence, and pharmacodynamics were also explored. | 2016 | 27437826 |
| oral treatment with valacyclovir for hsv-2-associated eczema herpeticum in a 9-month-old infant: a case report. | eczema herpeticum is a rare, severe, and disseminated infection of herpes simplex virus in the setting of eczematous skin diseases. | 2016 | 27442669 |
| incidence of and temporal relationships between hiv, herpes simplex ii virus, and syphilis among men who have sex with men in bangkok, thailand: an observational cohort. | high hiv incidence has been detected among men who have sex with men (msm) in thailand, but the relationship and timing of hiv, herpes simplex virus 2 (hsv-2), and syphilis is unknown. this analysis measures incidence, temporal relationships, and risk factors for hiv, hsv-2, and syphilis among at-risk msm in the bangkok msm cohort study. | 2016 | 27449012 |
| herpes simplex virus type 1 and type 2 in the netherlands: seroprevalence, risk factors and changes during a 12-year period. | genital herpes results in considerable morbidity, including risk of neonatal herpes, and is increasingly being caused by herpes simplex virus (hsv) type 1. possibly children are less often hsv-1 infected, leaving them susceptible until sexual debut. we assessed changes in the dutch hsv-1 and hsv-2 seroprevalence over time and determinants associated with hsv seropositivity. | 2016 | 27484304 |
| association of depressed mood with herpes simplex virus-2 immunoglobulin-g levels in pregnancy. | depressed mood is common in pregnancy, is associated with stress, and could result in immune suppression that may lead to latent herpes viral reactivation. this study investigated whether depressed mood is associated with higher herpes viral igg levels in pregnant women. | 2016 | 27490851 |
| atypical vzv retinitis in a patient with good syndrome. | to describe atypical varicella zoster virus (vzv) retinitis in a patient with good syndrome. | 2016 | 27494574 |
| assessment of igg antibodies against hsv1, hsv2, cmv and ebv in patients with pemphigus vulgaris versus healthy people. | regarding the implication of viruses particularly herpes in pemphigus vulgaris, we sought to assess and compare the level of immunoglobulin g (igg) antibodies against herpes simplex virus types 1 and 2 (hsv1 and hsv2), cytomegalovirus (cmv) and epstein-barr virus (ebv) in patients with pemphigus vulgaris and healthy people. | 2015 | 27507994 |
| role of type-specific herpes simplex virus-1 and 2 serology as a diagnostic modality in patients with clinically suspected genital herpes: a comparative study in indian population from a tertiary care hospital. | type-specific serology (tss) test for herpes simplex virus (hsv) have been used as a research tool in seroepidemiological studies for some years. however, tss as a diagnostic modality for diagnosis of current episode of genital herpes is not well documented. | 2017 | 27510668 |
| the role of human papilloma virus and herpes viruses in the etiology of nasal polyposis. | the aim of this study was to investigate the etiological role of human papilloma virus (hpv), herpes simplex virus (hsv), varicella-zoster virus (vzv), epstein-barr virus (ebv), cytomegalovirus (cmv), and human herpes virus-6 (hhv-6) and -7 (hhv-7) in the occurrence of nasal polyposis. | 2016 | 27511490 |
| b virus (macacine herpesvirus 1) divergence: variations in glycoprotein d from clinical and laboratory isolates diversify virus entry strategies. | b virus (macacine herpesvirus 1) can cause deadly zoonotic disease in humans. molecular mechanisms of b virus cell entry are poorly understood for both macaques and humans. here we investigated the abilities of clinical b virus isolates to use entry receptors of herpes simplex viruses (hsv). we showed that resistant b78h1 cells became susceptible to b virus clinical strains upon expression of either human nectin-2 or nectin-1. antibody against glycoprotein d (gd) protected these nectin-bearing c ... | 2016 | 27512063 |
| attitudes and willingness to assume risk of experimental therapy to eradicate genital herpes simplex virus infection. | current treatment of genital herpes is focused on ameliorating signs and symptoms but is not curative. however, as potential herpes simplex virus (hsv) cure approaches are tested in the laboratory, we aimed to assess the interest in such studies by persons with genital herpes and the willingness to assume risks associated with experimental therapy. | 2016 | 27513383 |
| structural characterization and antiviral effect of a novel polysaccharide psp-2b from prunellae spica. | in the present study, a novel polysaccharide, psp-2b, was isolated from aqueous extracts of prunellae spica by direct ultrafiltration membrane separation and gel chromatography purification. psp-2b is a partially sulphated polysaccharide with a molecular weight of approximately 32kda. its sulfate content is 10.59% by elemental analysis. the major sugars comprising psp-2b are arabinose, galactose and mannose, in addition to small amounts of glucose and uronic acids. the framework of psp-2b is spe ... | 2016 | 27516321 |
| mechanistic studies of viral entry: an overview of dendrimer-based microbicides as entry inhibitors against both hiv and hsv-2 overlapped infections. | this review provides an overview of the development of different dendrimers, mainly polyanionic, against human immunodeficiency virus (hiv) and genital herpes (hsv-2) as topical microbicides targeting the viral entry process. vaginal topical microbicides to prevent sexually transmitted infections such as hiv and hsv-2 are urgently needed. to inhibit hiv/hsv-2 entry processes, new preventive targets have been established to maximize the current therapies against wild-type and drug-resistant virus ... | 2017 | 27518199 |
| could zinc oxide tetrapod nanoparticles be used as an effective immunotherapy against hsv-2? | 2016 | 27527812 | |
| hsv-2 δgd elicits fcγr-effector antibodies that protect against clinical isolates. | a single-cycle herpes simplex virus (hsv) deleted in glycoprotein d (δgd-2) elicited high titer hsv-specific antibodies (abs) that (i) were rapidly transported into the vaginal mucosa; (ii) elicited antibody-dependent cell-mediated cytotoxicity but little neutralization; (iii) provided complete protection against lethal intravaginal challenge; and (iv) prevented establishment of latency in mice. however, clinical isolates may differ antigenically and impact vaccine efficacy. to determine the bre ... | 2016 | 27536733 |
| progesterone augments cell susceptibility to hiv-1 and hiv-1/hsv-2 co-infections. | in human immunodeficiency virus type 1 (hiv-1)-infected women, oral or injectable progesterone containing contraceptive pills may enhance hiv-1 acquisition in vivo, and the mechanism by which this occurs is not fully understood. in developing countries, herpes simplex virus type-2 (hsv-2) co-infection has been shown to be a risk for increase of hiv-1 acquisition and, if co-infected women use progesterone pills, infections may increase several fold. in this study, we used an in vitro cell culture ... | 2016 | 27538988 |
| mzc gel inhibits shiv-rt and hsv-2 in macaque vaginal mucosa and shiv-rt in rectal mucosa. | the population council's microbicide gel mzc (also known as pc-1005) containing miv-150 and zinc acetate dihydrate (za) in carrageenan (cg) has shown promise as a broad-spectrum microbicide against hiv, herpes simplex virus (hsv), and human papillomavirus. previous data show antiviral activity against these viruses in cell-based assays, prevention of vaginal and rectal simian-human immunodeficiency virus reverse transcriptase (shiv-rt) infection, and reduction of vaginal hsv shedding in rhesus m ... | 2017 | 27552154 |
| prevalence of herpesviruses in gingivitis and chronic periodontitis: relationship to clinical parameters and effect of treatment. | assess the prevalence of herpesviruses in healthy subjects, gingivitis, and chronic periodontitis patients, to assess the relationship between the prevalence of herpesviruses and periodontal clinical parameters, and to evaluate the effect of phase-i therapy on the level of viral detection. | 2017 | 27563201 |
| adenovirus-mediated shrna interference against hsv-1 replication in vitro. | the ul29 and ul28 proteins encoded by herpes simplex virus type 1 (hsv-1) are critical for its replication and packaging, respectively. research has demonstrated that synthesized sirna molecules targeting the ul29 gene are able to suppress hsv-2 replication and the ul28-null hsv-1 gene cannot form infectious viruses in vitro. silencing the ul28 and ul29 genes by rnai might lead to the development of novel antiviral agents for the treatment of hsv-1 infections. two kinds of short hairpin rnas (sh ... | 2016 | 27566181 |
| secreted herpes simplex virus-2 glycoprotein g alters thermal pain sensitivity by modifying ngf effects on trpv1. | genital herpes is a painful disease frequently caused by the neurotropic pathogen herpes simplex virus type 2 (hsv-2). we have recently shown that hsv-2-secreted glycoprotein g (sgg2) interacts with and modulates the activity of the neurotrophin nerve growth factor (ngf). this interaction modifies the response of the ngf receptor trka, increasing ngf-dependent axonal growth. ngf is not only an axonal growth modulator but also an important mediator of pain and inflammation regulating the amount, ... | 2016 | 27576911 |
| an escalating dose study to assess the safety, tolerability and immunogenicity of a herpes simplex virus dna vaccine, cor-1. | this paper describes a single site, open-label phase i clinical trial evaluating the safety, tolerability and immunogenicity in healthy volunteers of a herpes simplex polynucleotide vaccine that has previously been shown to enhance immunogenicity and protect against lethal herpes simplex virus type 2 (hsv-2) challenge in mice. five escalating doses of the vaccine, cor-1, were given by intradermal injection to hsv-1 and 2 seronegative healthy individuals. cor-1 was found to be safe and well-toler ... | 2016 | 27580249 |
| ficus religiosa l. bark extracts inhibit infection by herpes simplex virus type 2 in vitro. | ficus religiosa extracts have been used in traditional indian medicine to treat sexually transmitted infections such as gonorrhea and genital ulcers. the aim of this study was to investigate the antiviral activity of f. religiosa extracts against herpes simplex virus type 2 (hsv-2), the main causative agent of genital ulcers and sores. water and chloroform bark extracts were the most active against hsv-2, and also against an acyclovir-resistant strain. we demonstrate that the water extract has a ... | 2016 | 27581805 |
| occurrence of viral dna in paired samples of corneal rim and cornea preservation fluid. | corneal transplants have one of the highest success rates among all transplantological procedures. corneas intended for transplantation are stored in a preservation fluid, which is then tested for bacterial and fungal infections. among all analyses of infectious complications following corneal transplants, infections caused by bacteria or fungi are the most prominent. surprisingly, however, apart from a few publications, there is a lack of data regarding the occurrence of viruses in donor cornea ... | 2017 | 27588373 |
| altered gene expression of glycosyltransferases and sialyltransferases and total amount of glycosphingolipids following herpes simplex virus infection. | there is a case report of a patient with overlapping guillain-barré syndrome and bickerstaff brainstem encephalitis after infection with herpes simplex virus type 1 (hsv-1), who carried high titers of serum anti-gq1b igg antibodies. several studies have linked viral infection to the modulation of ganglioside expression such as human t-lymphotropic virus to gd2 and simian virus 40 to gm3. also, enhancement of the expression of gm2 on the cell membrane after cytomegalovirus infection has been repo ... | 2016 | 27588895 |
| effects of female sex hormones on susceptibility to hsv-2 in vaginal cells grown in air-liquid interface. | the lower female reproductive tract (frt) is comprised of the cervix and vagina, surfaces that are continuously exposed to a variety of commensal and pathogenic organisms. sexually transmitted viruses, such as herpes simplex virus type 2 (hsv-2), have to traverse the mucosal epithelial lining of the frt to establish infection. the majority of current culture systems that model the host-pathogen interactions in the mucosal epithelium have limitations in simulating physiological conditions as they ... | 2016 | 27589787 |
| high hiv incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study. | recent upsurge of new hiv infections among men who have sex with men (msm) is a major concern in china. paucity of national-level information regarding the burden and predictors of this progressive epidemic of new infections called for a multi-centric, timely and comprehensive investigation. | 2016 | 27593703 |
| hsv-2 enhances zikv infection of the placenta and induces apoptosis in first-trimester trophoblast cells. | zika virus (zikv) has gained public concern for its association with microcephaly in infants born to zikv-infected mothers. to reach the fetus the virus must overcome the defense mechanisms provided by trophoblast cells. additionally, in the first trimester, the integrity of the placenta is critical for fetal protection as damage to differentiating trophoblast can affect placental formation and function. we sought to investigate the effect of zikv infection on trophoblast cells and the factors t ... | 2016 | 27613665 |
| marital age disparity among orphaned young women and their husbands: a mixed methods study in rural zimbabwe. | our study reports the results from a mixed method study comparing age-similar (as) marriages of orphaned young women to age disparate (ad) marriages, defined as spousal age difference of 5 or more years. research in zimbabwe and sub-saharan africa suggests that ad sexual relationships between older men and young women increase the risk for hiv but few studies have examined this association among married couples or explored why young women marry much older men. in this study, a total of 35 orphan ... | 2016 | 27614653 |
| shedding of hsv-1, hsv-2, cmv, and ebv in the saliva of hematopoietic stem cell transplant recipients at fundación homi - hospital de la misericordia, bogotá, d.c. | hematopoietic stem cell transplantation in pediatric patients is an alternative treatment for different diseases. the conditioning regimen for transplant predisposes recipients to the development of infections. viral infections by herpes simplex virus 1 (hsv-1), herpes simplex virus 2 (hsv-2), human cytomegalovirus (cmv), and epstein-barr virus (ebv), are the most common, and the leading cause of morbidity and mortality among these patients. these viruses lie dormant in various cell types and th ... | 2016 | 27622810 |
| linear biocompatible glyco-polyamidoamines as dual action mode virus infection inhibitors with potential as broad-spectrum microbicides for sexually transmitted diseases. | the initial steps of viral infections are mediated by interactions between viral proteins and cellular receptors. blocking the latter with high-affinity ligands may inhibit infection. dc-sign, a c-type lectin receptor expressed by immature dendritic cells and macrophages, mediates human immunodeficiency virus (hiv) infection by recognizing mannose clusters on the hiv-1 gp120 envelope glycoprotein. mannosylated glycodendrimers act as hiv entry inhibitors thanks to their ability to block this rece ... | 2016 | 27641362 |
| immune responses elicited by the gen-003 candidate hsv-2 therapeutic vaccine in a randomized controlled dose-ranging phase 1/2a trial. | gen-003 is a candidate therapeutic hsv-2 vaccine containing a fragment of infected cell protein 4 (icp4.2), a deletion mutant of glycoprotein d2 (gd2δtmr), and matrix-m2 adjuvant. in a dose-ranging phase 1/2a clinical trial, immunization with gen-003 reduced viral shedding and the percentage of reported herpetic lesion days. here we examine the immune responses in the same trial, to characterize vaccine-related changes in antibody and cell-mediated immunity. | 2016 | 27642130 |
| [factors related to syphilis and other infections among female drug users in shandong women's compulsory drug rehabilitation center in 2015]. | objective: to analyze the prevalence of hiv, syphilis and related factors among female drug users in shandong women's compulsory drug rehabilitation center(swcdrc). methods: during may 2015, we used a cluster sampling method for drug users in swcdrc, with a questionnaire and serological testing. we included respondents who volunteered to take part in this study, had clear histories of drug abuse, and had no symptoms of psychosis or current drug use; 451 women participated. the questionnaire addr ... | 2016 | 27655604 |
| a randomized safety and pharmacokinetic trial of daily tenofovir 1% gel in term and near-term pregnancy. | vaginal tenofovir (tfv) 1% gel may reduce incident hiv-1 and herpes simplex virus 2 infection. pregnancy may increase risk of hiv acquisition, and incident hiv in pregnancy potentiates perinatal hiv transmission. our objective was to investigate the safety and pharmacokinetics of seven days of tfv 1% vaginal gel in term and near-term pregnancy. | 2017 | 27658440 |
| detection of herpes simplex virus type 2 (hsv-2) -specific cell-mediated immune responses in guinea pigs during latent hsv-2 genital infection. | genital infections with herpes simplex virus type 2 (hsv-2) are a source of considerable morbidity and are a health concern for newborns exposed to virus during vaginal delivery. additionally, hsv-2 infection diminishes the integrity of the vaginal epithelium resulting in increased susceptibility of individuals to infection with other sexually transmitted pathogens. understanding immune protection against hsv-2 primary infection and immune modulation of virus shedding events following reactivati ... | 2016 | 27659010 |
| bovine herpesvirus type-1 glycoprotein k (gk) interacts with ul20 and is required for infectious virus production. | we have previously shown that the hsv-1 gk and ul20 proteins interact and function in virion envelopment, membrane fusion, and neuronal entry. alignment of the predicted secondary structures of gks encoded by bohv-1, hsv-1, hsv-2, ehv-1 and vzv indicated a high degree of domain conservation. two bohv-1 gk-null mutant viruses were created by either gk gene deletion or stop codon insertion. in addition, a v5 epitope-tag was inserted at the carboxyl terminus of gk gene to detect gk. the engineered ... | 2016 | 27661734 |
| anti-apoptotic function of herpes simplex virus -2 latency-associated transcript rl1 sequence and screening of its encoded micrornas. | the latency-associated transcript (lat) gene of herpes simplex virus (hsv)-2 is the only detectable viral gene expressed during latent infection in neurons. lat inhibits apoptosis and maintains latency by promoting the survival of infected neurons. however, whether lat functions during hsv-2 infection via its encoded rnas or via its encoded proteins remain unknown. increasing evidence has indicated that lat is likely to functionally promote the establishment of latent infection via lat-encoded m ... | 2016 | 27663158 |
| hsv2 reactivation and myelitis following influenza vaccination. | we report the case of a 57 year-old woman who developed transverse myelitis and acute hsv-2 reactivation following influenza vaccination. over the next 5 years, she experienced a fluctuating course of improvement and regression for both myelitis and herpes. | 2017 | 27668461 |
| hiv positive patient with hsv-2 encephalitis: case report. | incidence of brain infections in human immunodeficiency virus (hiv) positive patients is reduced after the availability of current high active antiretroviral therapy (haart). herpes simplex virus type 2 (hsv-2) is an infrequent cause of encephalitis in hiv patients despite it is frequently involved in sexual transmitted infections. here, we report a case of hsv-2 encephalitis occurring in a patient without full suppression of hiv replication within the brain. a 38 year-old hiv infected man was a ... | 2016 | 27668908 |
| first description of herpes simplex virus type 1 epididymo-orchitis: a new clinical form of herpes simplex virus infection during septic shock? | genital herpes is increasingly caused by herpes simplex virus type 1 (hsv-1), but recurrences are less frequent than with hsv-2. distinguishing between primary genital infection and reactivation can be difficult, but hsv-1 more often causes severe primary infections and fewer recurrences. however, as virus reactivation is common during septic shock, a severe form of hsv-1 reactivation can occur in locations other than the lungs, which remain the most common site. the case of a 79-year-old caucas ... | 2016 | 27672563 |
| role of bacterial exopolysaccharides as agents in counteracting immune disorders induced by herpes virus. | extreme marine environments, such as the submarine shallow vents of the eolian islands (italy), offer an almost unexplored source of microorganisms producing unexploited and promising biomolecules for pharmaceutical applications. thermophilic and thermotolerant bacilli isolated from eolian vents are able to produce exopolysaccharides (epss) with antiviral and immunomodulatory effects against herpes simplex virus type 2 (hsv-2). hsv-2 is responsible for the most common and continuously increasing ... | 2015 | 27682100 |
| genital hsv shedding among kenyan women initiating antiretroviral therapy. | genital ulcer disease (gud) prevalence increases in the first month of antiretroviral treatment (art), followed by a return to baseline prevalence by month 3. since most gud is caused by herpes simplex virus type 2 (hsv-2), we hypothesized that genital hsv detection would follow a similar pattern after treatment initiation. | 2017 | 27683204 |
| type-specific detection of herpes simplex virus type 1 and type 2 using the cobas® hsv 1 and 2 test on the cobas® 4800 platform. | hsv-1 and hsv-2 are among the most common causes of sexually transmitted infections (stis) globally. these infections are strongly associated with increased risk of hiv acquisition and rare, but devastating, neonatal disease. available treatment options can reduce hsv transmission and improve quality of life. accurate diagnosis early in disease can improve patient management. areas covered: this paper describes the clinical manifestations of hsv infection often used for clinical diagnostic purpo ... | 2016 | 27687862 |
| herpes simplex virus particles interact with chemokines and enhance cell migration. | herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2, respectively) are among the most prevalent human pathogens, causing a variety of diseases. hsv modulation of the chemokine network remains poorly understood. we have previously identified secreted glycoprotein g (sgg) as the first viral chemokine-binding protein that enhances chemokine function as a novel viral immunomodulatory mechanism. however, gg is also present at the viral envelope and its role in the virus particle remains unknown. ... | 2016 | 27692045 |
| distribution and effects of amino acid changes in drug-resistant α and β herpesviruses dna polymerase. | emergence of drug-resistance to all fda-approved antiherpesvirus agents is an increasing concern in immunocompromised patients. herpesvirus dna polymerase (dnapol) is currently the target of nucleos(t)ide analogue-based therapy. mutations in dnapol that confer resistance arose in immunocompromised patients infected with herpes simplex virus 1 (hsv-1) and human cytomegalovirus (hcmv), and to lesser extent in herpes simplex virus 2 (hsv-2), varicella zoster virus (vzv) and human herpesvirus 6 (hhv ... | 2016 | 27694307 |
| school-based sexual health education interventions to prevent sti/hiv in sub-saharan africa: a systematic review and meta-analysis. | school-based sexual health education has the potential to provide an inclusive and comprehensive approach to promoting sexual health among young people. we reviewed evaluations of school-based sexual health education interventions in sub-saharan africa to assess effectiveness in reducing sexually transmitted infections and promoting condom use. | 2016 | 27724886 |