Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| sequence of the mitochondrial genome of pneumocystis carinii: implications for biological function and identification of potential drug targets. | 2006 | 17169041 | |
| draft assembly and annotation of the pneumocystis carinii genome. | 2006 | 17169080 | |
| co-infection of pneumocystis carinii f. sp. suis and porcine circovirus-2 (pcv2) in pig lungs obtained from slaughterhouses in southern and midwestern regions of brazil. | 2006 | 17169081 | |
| responsibility in naming pathogens: the case of pneumocystis jirovecii, the causal agent of pneumocystis pneumonia. | 2007 | 17182335 | |
| interaction of pneumocystis carinii with dendritic cells and resulting host responses to p. carinii. | to assess the interaction of pneumocystis carinii with dendritic cells (dcs), and the consequences of the response of the host immune system to p. carinii antigens when dc are pulsed with p. carinii, murine dc were pulsed with p. carinii, and the resultant p. carinii host responses assessed in vitro and in vivo. p. carinii interacted with murine bone marrow-derived dc in vitro in part via mannose receptors. dc pulsed with p. carinii did not demonstrate increased expression of the cell surface ma ... | 2007 | 17198083 |
| interleukin 7 receptor alpha-chain-mutation severe combined immunodeficiency without lymphopenia: correction with haploidentical t-cell-depleted bone marrow transplantation. | severe combined immunodeficiency (scid) is a rare primary immunodeficiency characterized by abnormal lymphocyte development and lymphopenia. it often presents during the first year of life with recurrent, opportunistic infections, failure to thrive, and malabsorption. | 2006 | 17201233 |
| identification and characterization of rad51 of pneumocystis. | rad51, a eukaryotic homolog of reca, is an important protein involved in dna recombination and repair. we have characterized rad51 of pneumocystis carinii and pneumocystis murina. rad51 is a single copy gene that encodes a 1.2 kb mrna, which contains an open reading frame encoding 343 amino acids. rad51 from pneumocystis showed high homology to those from yeast. atp binding motifs gefrtgks and llivd, similar to those of saccharomyces cerevisiae and schizosaccharomyces pombe, are conserved in pne ... | 2007 | 17207588 |
| herpes simplex virus (hsv) pneumonia in a heart transplant: diagnosis and therapy. | organ transplants are frequently complicated by viral infections. the period of maximum immunosuppression, 1 to 6 months posttransplantation, predisposes one to intracellular pathogens. the most common intracellular viral pathogens in transplant recipients include cytomegalovirus (cmv), herpes simplex virus (hsv), and respiratory syncytial virus (rsv). cytomegalovirus and hsv are common viral pathogens in the early transplant period (0-1 month posttransplant). although respiratory syncytial viru ... | 2007 | 17234480 |
| tuberculosis as a disease defining acquired immunodeficiency syndrome: ten years of surveillance in rio de janeiro, brazil. | to analyze the frequency of tuberculosis and of the other principal opportunistic infections defining acquired immunodeficiency syndrome at the time such cases were reported in the city of rio de janeiro, brazil. | 2006 | 17268749 |
| oral and nasal enteral tube placement errors and complications in a pediatric intensive care unit. | to report five cases of errors in the placement of oral/nasal enteral tubes in a pediatric intensive care unit, and to review literature on placement techniques and complication rates. | 2007 | 17273117 |
| [detection of pneumocystis carinii dna in air and washes from medical equipment in hospitals]. | results of study of rooms' air and washes from medical equipment by pcr assay to detect pneumocystis carinii dna are presented. pcr assay sensivity was 200 copies/ml. method of taking of air samples by mc-2 sample-taking device was modified for p. carinii detection. sensivity of the method was 10 copies/m3. 27 air samples and 105 washes from medical equipment were studied and p. carinii dna was not detected. it has been shown during the study that dna of pneumocysts remains intact at room temper ... | 2006 | 17297893 |
| pneumocystis stimulates mcp-1 production by alveolar epithelial cells through a jnk-dependent mechanism. | pneumocystis carinii is an opportunistic fungal pathogen that causes pneumonia (pcp) in immunocompromised individuals. recent studies have demonstrated that the host's immune response is clearly responsible for the majority of the pathophysiological changes associated with pcp. p. carinii interacts closely with alveolar epithelial cells (aecs); however, the nature and pathological consequences of the epithelial response remain poorly defined. monocyte chemotactic protein-1 (mcp-1) is involved in ... | 2007 | 17307812 |
| [a case of bronchiolitis due to pneumocystis lung infection related to major histocompatibility class ii deficiency]. | despite occurring commonly in children bronchiolitis can also be the presenting feature of other disorders particularly congenital malformations and immunological diseases. we report a rare and severe cause of bronchiolitis: major histocompatibility (mhc) class ii deficiency, an autosomal recessive disease. case report: an eight month old infant was admitted with hypoxic bronchiolitis. an immunodeficiency disease was suspected based on lingering symptoms associated with poor weight gain. microbi ... | 2006 | 17314748 |
| pneumocystis murina msg gene family and the structure of the locus associated with its transcription. | analysis of the pneumocystis murina msg gene family and expression-site locus showed that, as in pneumocystis carinii, p. murina msg genes are arranged in head-to-tail tandem arrays located on multiple chromosomes, and that a variety of msg genes can reside at the unique p. murina expression site. located between the p. murina expression site and attached msg gene is a block of 132 basepairs that is also present at the beginning of msg genes that are not at the expression site. the center of thi ... | 2007 | 17320432 |
| protein flexibility and species specificity in structure-based drug discovery: dihydrofolate reductase as a test system. | in structure-based drug discovery, researchers would like to identify all possible scaffolds for a given target. however, techniques that push the boundaries of chemical space could lead to many false positives or inhibitors that lack specificity for the target. is it possible to broadly identify the appropriate chemical space for the inhibitors and yet maintain target specificity? to address this question, we have turned to dihydrofolate reductase (dhfr), a well-studied metabolic enzyme of phar ... | 2007 | 17335207 |
| enhanced defense against pneumocystis carinii mediated by a novel dectin-1 receptor fc fusion protein. | pneumocystis carinii (pc) pneumonia is a leading opportunistic infection found among hiv-infected individuals worldwide. although cd4(+) t cell deficiency clearly correlates with susceptibility to pc pneumonia, murine models of disease indicate that pc-directed abs may prevent infection and/or inhibit growth of existing pc within the lungs. recognition of pc by alveolar macrophages involves the beta-glucan receptor dectin-1 and macrophage effector function against pc is enhanced by abs derived f ... | 2007 | 17339468 |
| prophylaxis of pneumocystis carinii pneumonia with atovaquone in children with leukemia. | despite extensive studies of atovaquone in human immunodeficiency virus (hiv)-infected patients, there is little information about its efficacy as a prophylactic agent for pneumocystis carinii pneumonia (pcp) in pediatric patients with cancer. therefore, a retrospective analysis was conducted to determine the incidence of pcp in pediatric patients who received prophylactic atovaquone during treatment for acute leukemia. | 2007 | 17345613 |
| noninfectious entry of hiv-1 into peripheral and brain macrophages mediated by the mannose receptor. | although protein receptors on the plasma membrane involved in the initial steps of productive hiv-1 infection have been well characterized, little is known about interactions between cellular carbohydrate receptors and hiv-1. here, we report the involvement of a carbohydrate receptor, the macrophage mannose receptor (mr), and its role in supporting hiv-1 binding and entry. hiv-1 can enter the cytoplasm of human macrophages and microglia as well as murine macrophages by mr, although no subsequent ... | 2007 | 17360361 |
| pharmacokinetics and metabolism of the prodrug db289 (2,5-bis[4-(n-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug db75 (2,5-bis(4-guanylphenyl)furan dihydrochloride). | db289 (pafuramidine maleate; 2,5-bis[4-(n-methoxyamidino)phenyl]furan monomaleate) is a prodrug of db75 (furamidine dihydrochloride; 2,5-bis(4-guanylphenyl)furan dihydrochloride), an aromatic dication related to pentamidine that has demonstrated good efficacy against african trypanosomiasis, pneumocystis carinii pneumonia, and malaria, but lacks adequate oral availability. the pharmacokinetics and metabolism of 14c-db289 have been investigated in rat and monkey after oral and intravenous adminis ... | 2007 | 17360833 |
| [observation on the ultrastructure of pneumocystis carinii]. | to study the life cycle and morphology of pneumocystis carinii by ultrastructural observation. | 2006 | 17366977 |
| [electron microscopical observation on rats with pneumocystis carinii pneumonia treated with brucea javanica and fructus psoraleae]. | rats with pneumocystis carinii pneumonia (pcp) were established by hypodermic injection of dexamethasone and treated by brucea javanica combined with fructus psoraleae 2 ml (brucea javanica 0.12 mg and fructus psoraleae 1.0 mg) per rat per day for 7 days or 14 days. the effect of cyst-killing and the pathological change were observed under transmission electron microscope. lung damage was alleviated or repaired, and a significant reduction of cysts was shown in the treatment group. the results s ... | 2006 | 17366985 |
| differentiating pneumocystis cysts from candida sp. yeasts in pulmonary specimens using methenamine silver. | pneumocystis carinii (pc) pneumonia in the immunocopromised patient requires prompt therapeutic intervention; therefore, rapid identification of pc organisms in cytopathologic specimen is essential. conclusive diagnoses of pc are achievable using grocott's methenamine silver (gms), the "gold-standard" stain for pc cyst visualization. however, non-budding candida sp. yeasts can simulate pc cysts with gms and thus pose significant diagnostic challenges. after qualitative and semi-quantitative anal ... | 1996 | 17372436 |
| parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex. | hydroxy-naphthoquinones are competitive inhibitors of the cytochrome bc(1) complex that bind to the ubiquinol oxidation site between cytochrome b and the iron-sulfur protein and presumably mimic a transition state in the ubiquinol oxidation reaction catalyzed by the enzyme. the parameters that affect efficacy of binding of these inhibitors to the bc(1) complex are not well understood. atovaquone, a hydroxy-naphthoquinone, has been used therapeutically to treat pneumocystis carinii and plasmodium ... | 2007 | 17383607 |
| pneumocystis carinii jiroveci pneumonia following infliximab infusion for crohn disease: emphasis on prophylaxis. | 2007 | 17402149 | |
| interleukin-23 (il-23)-il-17 cytokine axis in murine pneumocystis carinii infection. | host defense mechanisms against pneumocystis carinii are not fully understood. previous work in the murine model has shown that host defense against infection is critically dependent upon host cd4(+) t cells. the recently described th17 immune response is predominantly a function of effector cd4(+) t cells stimulated by interleukin-23 (il-23), but whether these cells are required for defense against p. carinii infection is unknown. we tested the hypothesis that p. carinii stimulates the early re ... | 2007 | 17403873 |
| erythrocytes as funguslike artifacts in pulmonary cytology. | 2007 | 17425214 | |
| a background and critical analysis of the treatment of pneumocystis carinii pneumonia (pcp) in hiv/aids. | 2007 | 17441498 | |
| pneumocystis carinii pneumonia in a rheumatoid arthritis patient treated with adalimumab. | patients with rheumatoid arthritis (ra) have an increased risk of infection as a result of alterations in immune regulation, debility, and comorbid illnesses. tnf-alpha is of central importance in the pathophysiological responses to infection and inflammation, and plays a crucial role in host defence. pneumocystis carinii is an opportunistic pathogen that commonly affects individuals with inadequate t-cell mediated immune response. patients with acquired immune deficiency, as well as those recei ... | 2007 | 17464877 |
| pneumocystis carinii pneumonia in immunocompromised host--an autopsy report of three cases. | 2007 | 17474255 | |
| the role of the beta-glucan receptor dectin-1 in control of fungal infection. | during fungal infection, a variety of receptors initiates immune responses, including tlr and the beta-glucan receptor dectin-1. tlr recognition of fungal ligands and subsequent signaling through the myd88 pathway were thought to be the most important interactions required for the control of fungal infection. however, recent papers have challenged this view, highlighting the role of dectin-1 in induction of cytokine responses and the respiratory burst. two papers, using independently derived, de ... | 2007 | 17475782 |
| exogenous heat-killed escherichia coli improves alveolar macrophage activity and reduces pneumocystis carinii lung burden in infant mice. | pneumocystis carinii is an opportunistic fungal pathogen that causes life-threatening pneumonia in immunocompromised individuals. infants appear to be particularly susceptible to pneumocystis pulmonary infections. we have previously demonstrated that there is approximately a 3-week delay in the clearance of pneumocystis organisms from pup mouse lungs compared to that in adults. we have further shown that there is approximately a 1-week delay in alveolar macrophage activation in pups versus adult ... | 2007 | 17485459 |
| transcriptome of pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. | members of the genus pneumocystis are fungal pathogens that cause pneumonia in a wide variety of mammals with debilitated immune systems. little is known about their basic biological functions, including life cycle, since no species can be cultured continuously outside the mammalian lung. to better understand the pathological process, about 4500 ests derived from sequencing of the poly(a) tail ends of p. carinii mrnas during fulminate infection were annotated and functionally characterized as un ... | 2007 | 17487271 |
| hypercalcemia and suppressed pth levels in a renal transplant patient infected with pneumocystis carinii. | pneumocystis carinii pneumonia is a serious and relatively common complication of immunosuppressive therapy. in immunocompromised patients, p. carinii pneumonia can cause significant morbidity and mortality. another common complication, typically seen in the subpopulation of renal transplant recipients, is hypercalcemia. the prevalence of hypercalcemia varies, reaching as high as 71%. we report the case of a renal transplant recipient who developed p. carinii pneumonia and hypercalcemia, the lat ... | 2007 | 17497478 |
| carbamate prodrugs of n-alkylfuramidines. | the synthesis and evaluation of 2,5-bis[4-(n-ethoxycarbonyl-n'-isopropyl)amidinophenyl]furan, 2,5-bis[4-(n-2,2,2-trichloroethoxycarbonyl-n'-isopropyl)amidinophenyl]furan and 2,5-bis[4-(n-cyclopentyl-n'-2,2,2-trichloroethoxycarbonyl)amidinophenyl]furan as prodrugs of bis-n-alkylamidines are reported. the results show that the bis-2,2,2-trichloroethyl carbamates function effectively in a rat model for pneumocystis pneumonia. | 2008 | 17499888 |
| audit of pneumocystis pneumonia in patients seen by the christchurch hospital rheumatology service over a 5-year period. | the aim of the study was to review all cases of pneumocystis carinii pneumonia (pcp) in patients seen by the christchurch hospital rheumatology service over a 5-year period and to determine the annual incidence of pcp. | 2007 | 17517083 |
| usefulness of beta-d glucan in diagnosing pneumocystis carinii pneumonia and monitoring its treatment in a living-donor liver-transplant recipient. | pneumocystis carinii pneumonia (pcp) is one of the fatal complications encountered after liver transplantation. the diagnosis of pcp is sometimes very difficult, because detection of the bacteria itself is not easy under some conditions, and the serum level of the chemical mediator is not yet considered to be a definitive diagnostic marker. we report a case of pcp that occurred 3 months after transplantation in a living-donor liver-transplant recipient; the disease developed during the course of ... | 2007 | 17520208 |
| scavenger receptor a dampens induction of inflammation in response to the fungal pathogen pneumocystis carinii. | alveolar macrophages are the effector cells largely responsible for clearance of pneumocystis carinii from the lungs. binding of organisms to beta-glucan and mannose receptors has been shown to stimulate phagocytosis of the organisms. to further define the mechanisms used by alveolar macrophages for clearance of p. carinii, mice deficient in the expression of scavenger receptor a (sra) were infected with p. carinii, and clearance of organisms was monitored over time. sra-deficient (srako) mice c ... | 2007 | 17548480 |
| design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates. | the classical antifolate n-{4-[(2,4-diamino-5-ethyl-7h-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoyl}-l-glutamic acid (2) and 15 nonclassical analogues (3-17) were synthesized as potential dihydrofolate reductase (dhfr) inhibitors and as antitumor agents. 5-ethyl-7h-pyrrolo[2,3-d]pyrimidine-2,4-diamine (20) served as the key intermediate to which various aryl thiols and a heteroaryl thiol were appended at the 6-position via an oxidative addition reaction. the classical analogue 2 was synthesized ... | 2007 | 17552508 |
| [pneumocystis carinii pneumonia in a patient with hyper-ige syndrome]. | a 15-year-old girl with abnormal findings detected on a medical check-up chest x-ray film was admitted to our center. high-resolution computed tomography, performed upon hospitalization, demonstrated panlobular nodular darkening in left lung fields, and an expanding, blended, map-like darkening near the pleura. since a grocott stain-positive cyst was confirmed histopathologically by transbronchial lung biopsy, the patient was given a diagnosis of pneumocystis carinii pneumonia. drug therapy was ... | 2007 | 17554982 |
| novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation. | two boron-containing, ortho-icosahedral carborane lipophilic antifolates were synthesized, and the crystal structures of their ternary complexes with human dihydrofolate reductase (dhfr) and dihydronicotinamide adenine dinucleotide phosphate were determined. the compounds were screened for activity against dhfr from six sources (human, rat liver, pneumocystis carinii, toxoplasma gondii, mycobacterium avium, and lactobacillus casei) and showed good to modest activity against these enzymes. the co ... | 2007 | 17569517 |
| improved detection of pneumocystis jirovecii infection in a tertiary care reference hospital in india. | we prospectively examined 143 clinical samples from 115 patients including both hiv infected (n=53) and hiv uninfected immunocompromized (n=62) patients, with lung infiltrates and with clinical features suggestive of pneumocystis carinii pneumonia/ pneumocystis pneumonia (pcp), using both microscopic techniques as well as pcr assay. clinical samples in the present study consisted of bronchoalveolar lavage (bal), tracheal aspirate (ta), nasopharyngeal aspirate (npa), sputum and gastric aspirate ( ... | 2007 | 17577820 |
| estimation of cd4+ and cd8+ t-lymphocytes in human immunodeficiency virus infection and acquired immunodeficiency syndrome patients in manipur. | to estimate and stratify cd4 + and cd8 + t-lymphocyte levels in human immunodeficiency virus (hiv) infected (asymptomatic) and acquired immunodeficiency syndrome (aids) patients (symptomatic) and correlate the clinical features of the patients with cd4+ and cd8+ lymphocyte level. | 2007 | 17582182 |
| phase i study of the combination of nedaplatin and weekly paclitaxel in patients with advanced non-small cell lung cancer. | this trial was conducted to determine the maximum tolerated dose (mtd), principal toxicity, and recommended dose for phase ii study of the combination of nedaplatin and weekly paclitaxel in patients with advanced non-small cell lung cancer (nsclc). | 2008 | 17589845 |
| canadian recommendations for the treatment of glioblastoma multiforme. | recommendation 1: management of patients with glioblastoma multiforme (gbm) should be highly individualized and should take a multidisciplinary approach involving neuro-oncology, neurosurgery, radiation oncology, and pathology, to optimize treatment outcomes. patients and caregivers should be kept informed of the progress of treatment at every stage. recommendation 2: sufficient tissue should be obtained during surgery for cytogenetic analysis and, whenever feasible, for tumour banking. recommen ... | 2007 | 17593983 |
| hiv-associated maternal mortality--primary causes of death at king edward viii hospital, durban. | the maternal mortality ratio in poor countries is reported to be 650/100,000 live births. this high maternal mortality may be associated with increasing numbers of hiv related deaths in sub-saharan africa. | 2007 | 17599219 |
| successful intermittent prophylaxis with trimethoprim/sulfamethoxazole 2 days per week for pneumocystis carinii (jiroveci) pneumonia in pediatric oncology patients. | this study was conducted to determine the efficacy of dosing trimethoprim/sulfamethoxazole on 2 consecutive days per week for the prevention of pneumocystis carinii (jiroveci) pneumonia in a pediatric leukemia and lymphoma population and to determine whether trimethoprim/sulfamethoxazole contributes to neutropenia during maintenance therapy. | 2007 | 17606548 |
| (1->3)beta-d-glucan assay positivity in patients with pneumocystis (carinii) jiroveci pneumonia. | 2007 | 17606968 | |
| clinical features of hiv/aids patients presenting to an inner city clinic in ho chi minh city, vietnam. | an outpatient hiv clinic was opened in march 2005 in binh thanh district, a poor section of ho chi minh city, vietnam. over 1500 patients were seen in the first year. the average age of patients was 27 years. men represented 77% of the clinic population, women, 23% and children under the age of 16 years of age, 5% of the population. the most common risk factor among men was being an injecting drug user (idu), 76%, and among women, being married to an idu hiv-positive man, 35%. physical signs of ... | 2007 | 17623507 |
| [continuous axenic cultivation of pneumocystis carinii isolated from the bronchoalveolar lavage fluid of infected rat]. | to establish axenic cultivation of pneumocystis carinii (p.c). | 2007 | 17633824 |
| [the characteristics of opportunistic infections in 181 hiv/aids patients in china]. | to investigate the spectra of opportunistic infections (ois) in hiv/aids patients in china and evaluate the relation between ois and cd(4)(+), cd(8)(+) t cell counts so as to suggest when the prophylaxis for ois should begin. | 2007 | 17637305 |
| [study on the changes of soluble intercellular adhesion molecule-1 level in sera of rats infected with pneumocystis carinii]. | to examine sicam-1 in pneumocystis carinii pneumonia (pcp) and the effect of tmp-smz therapy on its level and on pathological and immunological changes in rats. | 2007 | 17639695 |
| prevalence of bacterial and fungal agents causing lower respiratory tract infections in patients with human immunodeficiency virus infection. | this study was designed to document the prevalence of hiv associated respiratory infections in hyderabad. such studies have not been worked out before in this region. | 2004 | 17642682 |
| patients receiving standard-dose temozolomide therapy are at risk of pneumocystis carinii pneumonia. | 2007 | 17644327 | |
| [opportunistic invasive mycoses in aids. an autopsy study of 211 cases.]. | the opportunistic mycoses are an important cause of morbidity-mortality among patients with severe immunosuppression provoked by hiv. we present a study of 211 serial autopsies of patients with hiv/aids infection carried out by our service in a period of 10 years, observing frequency of invasive mycoses of the 44.1%. pneumocystis carinii infection was the most frequent (32%) with a prevalence of lung affection. candidiasis follows it in order of frequency with 31.1%, predominantly the oropharyng ... | 1998 | 17655402 |
| interstitial lung disease in infancy. | to describe the clinical profile of interstitial lung disease in infancy. | 2007 | 17699971 |
| oral trimethoprim/sulfamethoxazole in the treatment of acne vulgaris. | oral trimethoprim/sulfamethoxazole (tmp-smx) is approved by the us food and drug administration for the treatment of urinary tract infections, shigellosis, acute otitis media in pediatric patients, and pneumocystis carinii pneumonia. tmp-smx has been used off label in dermatology to treat various skin conditions, including acne vulgaris and other skin and soft tissue infections, especially those infections caused by methicillin-resistant staphylococcus aureus. | 2007 | 17713145 |
| extrapulmonary pneumocystis carinii infection in an aids patient: a case report. | extrapulmonary pneumocystis carinii (epc) infection is an uncommon condition, regardless of hiv status, and can occur as a complication of p carinii pneumonia (pcp). however, pcp is the most common severe opportunistic infection in patients with aids. the incidence of epc is variable, and in hiv-1-infected individuals it has been estimated to be 0.06-2.5%. | 2007 | 17718133 |
| [bilateral angle-closure glaucoma induced by trimetoprim and sulfamethoxazole combination: case report]. | sulfamethoxazole-trimethoprim (cotrimoxazole) is an antibiotic combination widely used for infections treatment and prophylaxis. these and others sulfonamides have been implicated in a rare syndrome of choroidal effusion with transient myopia and angle-closure glaucoma. previous cases reported in literature evolved to complete resolution after drug withdrawal. in contrast, we describe a rare case in which a patient developed the syndrome while taking cotrimoxazole, but did not recover visual acu ... | 2007 | 17768563 |
| prophylaxis of pneumocystis pneumonia in immunocompromised non-hiv-infected patients: systematic review and meta-analysis of randomized controlled trials. | to assess the efficacy of prophylaxis for pneumocystis pneumonia (pcp), caused by pneumocystis jirovecii (formerly pneumocystis carinii), for immunocompromised non-hiv-infected patients by conducting a systematic review and meta-analysis. | 2007 | 17803871 |
| pneumocystis carinii pneumonia in infant treated with oral steroids for hemangioma. | 2007 | 17875903 | |
| community-acquired pneumonia in thai patients with systemic lupus erythematosus. | infection, particularly pneumonia, is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (sle). this study was performed to assess the prevalence, causative organisms, and outcomes of community-acquired pneumonia (cap) in thai sle patients, and determine the predicting factors for death. a retrospective chart review of adult sle patients, age >16 years, seen at the division of rheumatology, chiang mai university over an 18 year period was carried out. cases di ... | 2007 | 17877230 |
| tc-99m red blood cell scintigraphic detection of cmv-induced small bowel hemorrhage. | a 4-month-old female child, recently diagnosed with parentally-acquired hiv complicated by moderate immunosuppression and pneumocystis carinii pneumonia (pcp), presented with hematochezia. a tc-99m bleeding study was performed and demonstrated a site of brisk bleeding in the distal ileum. the patient was taken to the operating room and resection of the distal ileum revealed the presence of cytomegalovirus (cmv) enteritis. in immunocompromised children presenting with gastrointestinal (gi) hemorr ... | 2007 | 17885365 |
| the recognition, physiology, and treatment of medication-induced methemoglobinemia: a case report. | dapsone is a leprostatic agent commonly prescribed for the management of leprosy, malaria, and the immunosuppression-induced infections of pneumocystis carinii and toxoplasma gondii. in susceptible patients, methemoglobinemia, a potentially life-threatening event, can occur. we report a case of dapsone-induced methemoglobinemia which was observed during general anesthesia for the management of a fractured mandible. the pathophysiology, diagnosis, and management of dapsone-induced methemoglobinem ... | 2007 | 17900210 |
| pneumocystis carinii pneumonia in a patient on etanercept for psoriatic arthritis. | pneumocystis carinii pneumonia (pcp) is a rare form of pneumonia associated with immune-suppression. it is common in patients with aids and with a cd4 count of less than 200 cells/mm(3). we report a case of pcp secondary to immune-suppression in a 41-year-old man with psoriatic arthritis being treated with the immune-modulatory agent etanercept. | 2007 | 17906888 |
| studies on fungal pumilio gene family through mining multiple genome-scale data sets. | the genes belonging to pumilio gene family of the fission yeast schizosaccharomyces pombe (s. pombe) were compared with genome information of the several fungi and their functions have been inferred using public-access databases disclosed on the internet websites. the pumilio-family genes are conserved from yeast to man and have been considered to suppress the expression of other genes by binding their specific target messenger rnas. in s. pombe genome, nine genes belonging to pumilio gene famil ... | 2007 | 17932456 |
| [primary cerebellar t-cell lymphoma]. | primary central nervous system t-cell lymphomas are rare and have to be differentiated from reactive lesions. it is therefore essential to use all possible tools to establish the diagnosis, including immunohistochemistry, molecular genetic analysis, and/or cytogenetic methods. in this paper we present the case of a primary cerebellar t-cell lymphoma in a 50-year-old man; a clonal t-cell receptor gene rearrangement was documented. after two cycles of methotrexate therapy the patient developed pne ... | 2008 | 17934733 |
| experience with alemtuzumab in treatment of chronic lymphocytic leukaemia in the netherlands. | alemtuzumab (mabcampath) is a monoclonal antibody against cd52, indicated as third-line treatment of chronic lymphocytic leukaemia (cll). as most important side effect opportunistic infections are mentioned. it is, however, unknown whether these complications often lead to problems in general patient care in the netherlands. | 2007 | 17954952 |
| correlations among measures of quality in hiv care in the united states: cross sectional study. | to determine whether a selected set of indicators can represent a single overall quality construct. | 2007 | 17967826 |
| pneumocystis carinii exhibits a conserved meiotic control pathway. | pneumocystis carinii is an opportunistic fungus causing severe pneumonia in immune-compromised hosts. recent evidence suggests that pneumocystis exists as separate sex types, though definitive evidence is currently lacking. these studies were undertaken to determine whether pneumocystis maintains functional meiotic control molecules, which are required for sexual life stages in eukaryotes. using the pneumocystis carinii genome project database, two partial sequences for meiotic control molecules ... | 2008 | 17984205 |
| functional characterization of pneumocystis carinii brl1 by transspecies complementation analysis. | pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immunocompromised humans. the brl1 gene of p. carinii infecting rats was identified and characterized by using bioinformatics in conjunction with functional complementation in saccharomyces cerevisiae and schizosaccharomyces pombe. the ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the brr6/brl1 family in both yeasts. | 2007 | 17993570 |
| [enzyme change in bronchoalveolar lavage fluid of pneumocystis pneumonia rats and the effect of garlicin treatment]. | to study the change of enzymes and effect of garlicin treatment on the change in bronchoalveolar lavage fluid (balf) of rats with pneumocystis carinii pneumonia (pcp). | 2007 | 18038800 |
| [construction and expression of prokaryotic expression plasmids of pneumocystis carinii p55 antigen gene fragment]. | to construct prokaryotic recombinant expression plasmid carrying pneumocystis carinii mr 55 000 antigen (p55) gene fragment and express the recombinant protein. | 2007 | 18038806 |
| valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy. | alemtuzumab is an immunosuppressive antibody that depletes normal t cells and b cells. prophylaxis for herpes virus and pneumocystis carinii is standard with this agent. approximately 20% to 25% of patients will experience cytomegalovirus (cmv) reactivation. we conducted a randomized trial wherein patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily or valganciclovir 450 mg orally twice daily. the study design planned to ... | 2008 | 18039954 |
| pneumocystis encodes a functional s-adenosylmethionine synthetase gene. | s-adenosylmethionine (adomet) synthetase (ec 2.5.1.6) is the enzyme that catalyzes the synthesis of adomet, a molecule important for all cellular organisms. we have cloned and characterized an adomet synthetase gene (sam1) from pneumocystis spp. this gene was transcribed primarily as an approximately 1.3-kb mrna which encodes a protein containing 381 amino acids in p. carinii or p. murina and 382 amino acids in p. jirovecii. sam1 was also transcribed as part of an apparent polycistronic transcri ... | 2008 | 18065654 |
| anti-pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. | a series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against pneumocystis carinii and plasmodium falciparum w2 strain. most compounds were active against p. carinii above 10 microg/ml and displayed slight to marked activity. the imidazolidin-4-ones most active against p. carinii were also those most active antiplasmodial agents, in the mum range. one of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a l ... | 2008 | 18077165 |
| cotrimoxazole-induced hypoglycemia in an hiv-infected patient. | a case of cotrimoxazole-induced hypoglycemia is described in a male patient infected with hiv. ten days after initiating high dose cotrimoxazole for suspected pneumocystis carinii pneumonia, the patient developed neuroglycopenic symptoms and diaphoresis. blood glucose levels were repeatedly low, with elevated insulin and c-peptide levels despite multiple intravenous bolus doses and infusions of dextrose. hypoglycemia resolved after approximately 36 h of treatment with dextrose and discontinuatio ... | 2001 | 18159355 |
| [pulmonary manifestations of acquired immunodeficiency syndrome (aids)]. | the lungs are the principal target organ in the infectious complications of acquired immunodeficiency syndrome (aids) and this predisposition to infections is not the regional manifestation of systemic immunologic deficiency induced by human immunodeficiency virus (hiv) only, because hiv also affects lung's own complex system of local defense mechanisms. it was demonstrated that pulmonary host defenses were compromised by.direct infection of alveolar macrophages with hiv and decreased production ... | 1992 | 18170978 |
| s-adenosylmethionine levels in the diagnosis of pneumocystis carinii pneumonia in patients with hiv infection. | s-adenosylmethionine (adomet) is a key molecule involved in methylation reactions and polyamine synthesis. pneumocystis carinii are unable to synthesize this molecule and have been shown to scavenge this metabolic intermediate from the plasma of rats during active infection. a prior study involving humans strongly suggested that low levels of plasma adomet are sensitive and specific indicators of acute infection. | 2008 | 18177224 |
| botryomycosis caused by staphylococcus aureus and pneumocystis carinii in a patient with acquired immunodeficiency disease. | botryomycosis is an uncommon, chronic, granulomatous and/or suppurative, opportunistic infection affecting the skin and viscera, primarily caused by bacteria. the exact pathogenesis of this infection is not well understood. however, both the host's immune status and microbial infectivity have been implicated in the pathogenesis of this unusual clinical condition. to date, botryomycosis caused by a nonbacterial pathogen has not been reported in the literature. we report a case of cutaneous botryo ... | 2008 | 18177488 |
| pneumocystis pcint1, a molecule with integrin-like features that mediates organism adhesion to fibronectin. | pneumocystis species cause severe pneumonia during chronic immunosuppression, especially in patients with aids or malignancy. adhesion of pneumocystis to extracellular matrix proteins, particularly fibronectin, associated with alveolar epithelial cell surfaces, triggers organism proliferative pathways. herein, we report the characterization of a novel pneumocystis molecule with considerable structural features of an integrin-like extracellular matrix adhesion receptor. a pcint1115 bp probe was i ... | 2008 | 18179594 |
| the effect of care team composition on the quality of hiv care. | compared to single-clinician care, care provided by multiple clinicians might result in higher-quality care, especially if some of them have condition-specific expertise and complementary knowledge, skills, and roles. individual physician continuity, which has been shown to be associated with care quality, necessarily decreases when care is provided by multiple clinicians. this study uses data from the hiv cost and services utilization study to assess the effect of care team composition on the q ... | 2008 | 18184871 |
| living unrelated renal transplant: outcome and issues. | living unrelated transplantation (lurt) is emerging as a practical option in renal transplantation due to shortage of living related and cadaver donors. we report a six-years (december 1991 to december 1996) follow-up of 60 lurt patients. the majority of these patients (95%) were transplanted outside the kingdom of saudi arabia; 37 in india, 14 in egypt, five in the usa and one in pakistan. only three patients (emotionally related) were transplanted in saudi arabia. before transplantation, 50 (8 ... | 2000 | 18209344 |
| molecular evidence of nosocomial pneumocystis jirovecii transmission among 16 patients after kidney transplantation. | in recent years, clusters of pneumocystis jirovecii (formerly pneumocystis carinii) pneumonia (pcp) among immunocompromised individuals have been reported. mostly, the source of infections was suspected to be within the clinical settings when transplant recipients and pcp patients shared hospital facilities. we report on a cluster of 16 renal transplant recipients positive for p. jirovecii. none of them received anti-pneumocystis prophylaxis prior to p. jirovecii detection. epidemiological studi ... | 2008 | 18216217 |
| type b insulin resistance syndrome induced by increased activity of systemic lupus erythematosus in a hemodialysis patient. | a-23-year-old woman with systemic lupus erythematosus (sle) and on hemodialysis for 5 years was admitted to the hospital because of severe general fatigue. on admission, laboratory findings showed that fasting plasma glucose levels ranged from 25 â 45 mg/dl, a test for antinuclear antibody (ana) was positive (1 : 320, with a discrete-speckled pattern), serum c3 and c4 complement and ch50 level were remarkably depressed (22.5 mg/dl, < 5.1 mg/dl, < 13 u/ml, respectively), and insulin receptor anti ... | 2008 | 18218307 |
| didactic lessons from the serum lactate dehydrogenase posttransplant: a clinical vignette. | posttransplant lymphoproliferative disorder (ptld) is a serious complication after solid organ transplantation. an elevated serum lactate dehydrogenase (ldh) is a marker of ptld activity. we report the case of a 58-year-old female renal transplant patient with a prior history of extranodal ptld, which developed 19 years after a second transplant. she was successfully treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (r-chop) and maintained subsequently on sirolimu ... | 2008 | 18294352 |
| it is time to move: pneumocystis jirovecii, not pneumocystis carinii. | 2008 | 18309025 | |
| dapsone induced acute photosensitivity dermatitis; a case report and review of literature. | dapsone is one of the main constituents of anti-leprosy treatment and has been in use for various dermatological and non-dermatological indications since the 1940s. dapsone-induced photosensitivity is a rare complication. only 11 cases seem to have been reported in the literature. we report a case of dapsone-induced photosensitivity in an indian patient with leprosy, and briefly review the literature. dapsone (diaminodiphenyl sulphone or dds) is the most commonly used anti-leprosy drug since the ... | 2007 | 18309716 |
| respiratory infection complicating hiv infection. | respiratory infections remain a major cause of morbidity among hiv-infected persons. thus, knowledge of recent advances regarding hiv-associated opportunistic pneumonias is crucial for optimal care of hiv-infected persons. | 2008 | 18317044 |
| interleukin-12 and host defense against murine pneumocystis pneumonia. | little is known about the role of the cytokine interleukin-12 (il-12) in pneumocystis pneumonia or its potential use as immunotherapy. we asked whether release of il-12 is part of the normal host response to this infection and whether local treatment with il-12 or gene transfer of il-12 could accelerate clearance of infection. il-12 was assayed by enzyme-linked immunosorbent assay in normal mice and in mice deficient in il-12 after inoculation of pneumocystis carinii. p. carinii-infected mice we ... | 2008 | 18332204 |
| [temozolomide: temodal]. | the oral alkylating agent, temozolomide (temodal: tmz), is the only anticancer drug that has been shown in a phase iii study to improve survival in glioblastoma (gbm) when administered with concomitant radiotherapy. pharmacokinetic studies have documented relatively high concentrations of tmz in brain tumors and cerebrospinal fluid (20-40% of the area under the plasma concentration curve), and other studies have demonstrated that tmz is effective for treatment of various brain tumors, including ... | 2008 | 18347414 |
| a pneumocystis carinii group i intron-derived ribozyme utilizes an endogenous guanosine as the first reaction step nucleophile in the trans excision-splicing reaction. | in the trans excision-splicing reaction, a pneumocystis carinii group i intron-derived ribozyme binds an rna substrate, excises a specific internal segment, and ligates the flanking regions back together. this reaction can occur both in vitro and in vivo. in this report, the first of the two reaction steps was analyzed to distinguish between two reaction mechanisms: ribozyme-mediated hydrolysis and nucleotide-dependent intramolecular transesterification. we found that the 3'-terminal nucleotide ... | 2008 | 18363339 |
| causes of the first aids-defining illness and subsequent survival before and after the advent of combined antiretroviral therapy. | to analyse the impact of combined antiretroviral treatment (cart) on survival with aids, according to the nature of the first aids-defining clinical illness (adi); to examine trends in aids-defining causes (adc) and non-aids-defining causes (non-adc) of death. | 2008 | 18366449 |
| [the diagnostic value of transbronchial lung biopsy in diffuse parenchymal lung diseases]. | this study was to evaluate the efficacy and limitations of transbronchial lung biopsy (tblb) in the diagnosis of diffuse parenchymal lung diseases (dpld). | 2008 | 18366902 |
| novel bisbenzimidazoles with antileishmanial effectiveness. | a small library of 2,2'-[(alpha,omega-alkanediylbis(oxyphenylene)]bis-1h-benzimidazoles has been prepared and screened in vitro against pneumocystis carinii, trypanosoma brucei rhodesiense, and leishmania donovani. among the six tested compounds two derivatives emerged as promising hits characterized by ic(50) values lower than that determined for pentamidine against l. donovani. | 2008 | 18367395 |
| antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate. | 8-aminoquinolines are an important class of antiparasitic agents, with broad utility and excellent efficacy, but also limitations due to hematological toxicities, primarily methemoglobinemia and hemolysis. one representative from this class, (+/-)-8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate (npc1161c), proved extremely efficacious in animal models of malaria and pneumocystis pneumonia. this racemic mixture was separated into its component enanti ... | 2008 | 18378716 |
| hypobaric hypoxia-related impairment of pulmonary surfactant proteins a and d did not favour pneumocystis carinii frenkel 1999 growth in non-immunocompromised rats. | it has been suggested that patients with pulmonary surfactant impairment are more susceptible to pneumocystis infection than healthy controls. owing the fact that most patients with pulmonary surfactant impairment also suffer from hypoxia, we explored the effect of intermittent hypobaric hypoxia conditions on the ability of non-immunocompromised rats infected by endotracheal route with p. carinii to clear the infection from their lungs. control rats, inoculated or not with p. carinii, were maint ... | 2008 | 18416247 |
| pneumocystis carinii pneumonia after renal transplantation. | 1996 | 18417916 | |
| [effects of fructus psoralea and brucea javanica on the level of il-2 and nk cell in rats infected with pneumocystis carinii]. | sd rat model of pcp was established by subcutaneous injection with dexamethasone. the treatment groups received fructus psoralea (fp, 10.0 mg/kg), brucea javanica (bj, 1.2 mg/kg) and a mixture of the two chinese herbs(fp 5mg/kg, bj 0.6 mg/kg) respectively. by means of detecting the level of il-2 in sera and nk cells in spleens, the effect of fp and bj on the level of il-2 and nk cells in rats with pneumocystis carinii pneumonia (pcp) was observed, with smzco treatment group (tmp 50 mg/kg, smz 25 ... | 2007 | 18442007 |
| central retinal vein occlusion in an aids patient with presumed pneumocystis carinii pneumonia. | 2008 | 18443615 | |
| development of spray dried liposomal dry powder inhaler of dapsone. | this investigation was undertaken to evaluate practical feasibility of site specific pulmonary delivery of liposomal encapsulated dapsone (ds) dry powder inhaler for prolonged drug retention in lungs as an effective alternative in prevention of pneumocystis carinii pneumonia (pcp) associated with immunocompromised patients. ds encapsulated liposomes were prepared by thin film evaporation technique and resultant liposomal dispersion was passed through high pressure homogenizer. ds nano-liposomes ... | 2008 | 18446460 |