Publications

alcohol and liver injury: dose-related or permissive effect?	studies addressing the risk of development of cirrhosis of the liver in relation to alcohol consumption have been based on comparisons at the aggregate population level and, at the individual level, on case-control studies and cohort studies, and on retrospective and prospective assessment of alcohol consumption. the ideal, but unfeasible, study design for estimation of the risk function is a prospective monitoring of alcohol consumption and recording of the rate of development of cirrhosis per ...	2009	2671569
structure and regulation of the multigene family controlling maltose fermentation in budding yeast.		1989	2672110
[application of hemodilution to ischemic heart disease].		2008	2672312
malignant hyperthermia. potential crisis in patient care.		2009	2673033
the expression of enterotoxin a-b+ gene of v. cholerae in e. coli.	the cloning in e. coli of a cholerae toxin gene that is a-b+ has been successfully constructed by using dna recombinant techniques. e. coli cells carrying the recombinant plasmid pmm-ctb have been shown to produce a large amount of ctb subunits which are secreted as extracellular proteins.	1989	2673288
investigation of the structure of the capsular polysaccharide of escherichia coli k55 using klebsiella bacteriophage phi 5.	the structure of the capsular polysaccharide from escherichia coli o9:k55 (n 24c) has been studied, using methylation analysis, degradation by bacteriophage, and n.m.r. spectroscopy. depolymerisation of the k55 polysaccharide, using the lyase enzyme borne by klebsiella phi 5, yielded a tri- and a hexa-saccharide, analysis of which indicated the following repeating unit. (formula; see text) this structure differs from that for the repeating unit of the capsular polysaccharide of klebsiella k5 onl ...	1989	2673507
[clinical evaluation of renal autotransplantation in renal vascular hypertension].	from 1976 to 1984, 22 cases of renal vascular hypertension were treated with renal autotransplantation. 20 cases have been followed up for 3-11 years, 17 cases of them over 5 years. the results showed that 14 cases were cured, 5 cases relieved, 1 cases ineffective. 19 cases of these patients suffered from large arteritis, 3 cases from atherosclerosis. the clinical efficacy of the former was better than the later. our results suggest that the clinical efficacy has nothing to do with the course of ...	2009	2673688
use of temporary keratoprosthesis in the management of severe ocular trauma with retinal detachment and proliferative vitreoretinopathy.		2009	2673881
a risk assessment process for allergic contact sensitization.	this review describes an approach that has been used to assess the skin sensitization risk of new chemicals and product formulations prior to launching the new chemical or product on the market. the risk assessment process utilizes a comparative toxicological approach, in which data on the inherent toxicity of a material, and the exposure to it through manufacturing or consumer use or foreseeable misuse, are integrated and compared with data generated by 'benchmark' materials of similar chemistr ...	1989	2673957
a risk assessment process for allergic contact sensitization.	this review describes an approach that has been used to assess the skin sensitization risk of new chemicals and product formulations prior to launching the new chemical or product on the market. the risk assessment process utilizes a comparative toxicological approach, in which data on the inherent toxicity of a material, and the exposure to it through manufacturing or consumer use or foreseeable misuse, are integrated and compared with data generated by 'benchmark' materials of similar chemistr ...	1989	2673957
expression and detection of different biotype-associated cell-bound haemagglutinins of vibrio cholerae o1.	the expression of two cell-bound haemagglutinins, one sensitive to l-fucose (fsha) and the other to d-mannose (msha), on vibrio cholerae o1 strains of both the classical and the el tor biotypes was studied by (i) agglutination of chicken and human group o erythrocytes in the presence of l-fucose or d-mannose, (ii) binding of the bacteria to l-fucose- and d-mannose-coated agarose beads, and (iii) agglutination of the bacteria by 'biotype-specific' antisera. all of the 12 classical strains studied ...	1989	2674322
modeling of palmitate transport in the heart.	transport of palmitate from the albumin-palmitate complex in the plasma to inside mitochondria where it undergoes beta-oxidation is a multistep process. albumin's large size prevents permeation via interendothelial clefts. palmitate dissociation from albumin in solution is too slow to provide an adequate supply of the unbound palmitate. the discovery that the dissociation occurs upon albumin binding to an endothelial surface receptor resolves the conundrum. palmitate transport across the luminal ...	1989	2674667
modeling of palmitate transport in the heart.	transport of palmitate from the albumin-palmitate complex in the plasma to inside mitochondria where it undergoes beta-oxidation is a multistep process. albumin's large size prevents permeation via interendothelial clefts. palmitate dissociation from albumin in solution is too slow to provide an adequate supply of the unbound palmitate. the discovery that the dissociation occurs upon albumin binding to an endothelial surface receptor resolves the conundrum. palmitate transport across the luminal ...	1989	2674667
up-regulation of prostaglandin e2 binding and of prostanoid release in rabbits producing antibodies against prostaglandin e2.	german giant rabbits successfully immunized against prostaglandin (pg) e2 as shown by a rise in antibody titers developed gastric mucosal lesions. enzymatically dispersed gastric mucosal cells of these animals had a significantly enhanced production of pg e2 and pg i2 as measured by specific radioimmunoassays. this may be explained by an increased supply with endogenous arachidonic acid (as indicated by an enhanced phospholipase a2/lat ratio) and by a higher activity of the subsequent pg forming ...	1989	2675196
a biotin-streptavidin amplified enzymeimmunoassay for 13,14-dihydro-15-keto-pgf2 alpha.	as an alternative for radioimmunoassays a new enzyme immunoassay (eia) for the determination of 13,14-dihydro-15-keto pgf2 alpha (pgfm) has been developed. biocytin was linked to pgfm by the n-hydroxysuccinimide method and the product (biocytinyl-pgfm) purified by reversed phase column chromatography. biocytinyl-pgfm was used in the eia as a bridge between the immobilized pgfm-antibody and streptavidin-peroxidase. the absolute sensitivity of the assay was about 160 amol (92% rel. binding) and re ...	1989	2675197
[flow cytometry. advantages and disadvantages of analysis technics after embedding in paraffin].		2009	2675869
lung parasitoses.		2009	2676037
[primary malignant melanoma of the bladder. apropos of a case].	the authors report about a case of a primitive melanoma of the bladder that a man aged 77 years suffered of. the diagnosis was carried-out with certain difficulty on fragments of endoscopic resection and was discussed from the clinical facts as well as from the anatomo-pathological results and, more particularly, from the immuno-histochemical results. this study makes it possible that a comparison be made with those rare cases observed on a world-scale basis which are described in the literature ...	1989	2677153
[antibacterial and bactericidal activities of japanese green tea].	we found that extracts of japanese green tea leaves inhibited the growth of various bacteria causing diarrheal diseases. all tea samples tested showed antibacterial activity against staphylococcus aureus, s. epidermidis, vibrio cholerae o1, v. cholerae non o1. v. parahaemolyticus, v. mimicus, campylobacter jejuni and plesiomonas shigelloides. none of the tea samples had any effect on the growth of v. fluvialis, aeromonas sobria, a. hydrophila, pseudomonas aeruginosa, salmonella enteritidis, ente ...	1989	2677434
[a case of chronic bronchitis with pasteurella multocida possibly resulting from infection from a bird].	a 60-year-old woman was admitted to our division for further evaluation of fever and purulent sputa. in sputum cultures performed when the patient had complained of an increase in symptoms on three occasions during the previous 6 months, pasteurella multicoida was usually detected. based on the fact that the bacteria had been detected from the patient's sputa after feeding a macaw, but was not detected after treatment of the bird with oflx, a diagnosis of respiratory tract infection by p. multoc ...	1989	2677461
effect of hyperglycemia on hepatic extraction of insulin in totally pancreatectomized dogs.	using the glucose clamp technique, we investigated the effect of blood glucose levels on hepatic extraction of insulin in pancreatectomized dogs. a primed continuous infusion of regular insulin was administered at a rate 1.5 mu/kg body wt./min into the portal or peripheral vein and the blood glucose level was clamped at hyperglycemia (over 200 mg/dl) or euglycemia (below 100 mg/dl) by a variable infusion of glucose through the saphenous or portal vein. plasma insulin concentrations were measured ...	1989	2677518
establishment and characterization of human glioblastoma cell lines in vitro and their xenografts in nude mice.	human gliomas were grown as permanent tissue cultures and xenografts in nude mice. growth kinetics, immunohistology and karyotypes were established. one tumor showed a distinct change in its karyotype after only two passages in nude mice; by contrast, no change of immunophenotype occurred during and after in vivo passaging. treatment of this glioma as xenograft in nude mice revealed a high sensitivity towards single agent treatment with bcnu. in view of the cytologic aberrations, however, this r ...	1989	2677876
rapid colony screening of yac libraries by using alginate as matrix support.		1989	2678011
[the use of imaging procedures following kidney transplantation--diagnostic strategy].	despite the continuously increasing number of successfully transplanted kidneys, graft and patient are still "threatened" by several postoperative complications as acute and chronic rejection, acute tubular necrosis, urologic and vascular complications and disorders caused by immunosuppressive medication. an early and safe detection of these conditions is of high clinical importance and a challenge to diagnostic imaging. all radiologic methods and nuclear medicine have their value for transplant ...	2008	2678232
[the use of imaging procedures following kidney transplantation--diagnostic strategy].	despite the continuously increasing number of successfully transplanted kidneys, graft and patient are still "threatened" by several postoperative complications as acute and chronic rejection, acute tubular necrosis, urologic and vascular complications and disorders caused by immunosuppressive medication. an early and safe detection of these conditions is of high clinical importance and a challenge to diagnostic imaging. all radiologic methods and nuclear medicine have their value for transplant ...	2008	2678232
abnormal insulin metabolism by specific organs from rats with spontaneous hypertension.	spontaneously hypertensive rats (shr) have been shown to be both insulin resistant and hyperinsulinemic after oral glucose administration or infusion of exogenous insulin during an insulin suppression test. to determine if this hyperinsulinemia may be due to decreased removal of insulin, the metabolic clearance (k) of insulin was measured in isolated perfused liver, kidney, and hindlimb skeletal muscle from shr and wistar-kyoto (wky) control rats. the data indicate that the k for insulin removal ...	1989	2679128
detection of intracellular canine distemper virus antigen in mink inoculated with an attenuated or a virulent strain of canine distemper virus.	using an indirect immunofluorescence technique, the distribution of viral antigen in various tissues and blood mononuclear leukocytes was studied in wild mink, either vaccinated with an attenuated vaccine strain of canine distemper virus (cdv) or experimentally inoculated with the virulent snyder-hill strain of cdv. viral antigen was detected in cells of the lymphoid system 6 to 12 days after vaccination. from 2 to 3 days after inoculation with the virulent strain, cdv antigen was demonstrated i ...	1989	2679253
induction of acantholysis in organ explant culture by penicillamine and captopril.	pemphigus is an autoimmune disease proved to be mediated by igg autoantibodies. skin lesions clinically and histologically identical to pemphigus may occur in patients receiving penicillamine and captopril, but some of these patients lack circulating or tissue-bound autoantibodies. therefore, we examined the ability of these drugs to produce acantholysis directly in organ explant culture. human skin explants were prepared from split-thickness graft skin from adults and from neonatal foreskins. e ...	1989	2679399
bone mass, muscle function and fracture of the proximal femur.	the epidemiology and pathogenesis of hip fractures are reviewed. there is evidence that physical inactivity and concomitant muscle weakness are important determinants of the risk of hip fracture.	2009	2679947
[regional strategy of surveillance of pathogenic agents of infectious diarrhea having epidemic potential].	the authors expose the strategy put into effect to identify quickly, and fight against the pathogenic agents responsible for epidemic outbreak in rural areas, which, until now--were not properly controlled.	1989	2680134
converging and diverging pathways in polypeptide hormone action.		2008	2680229
evolution of dialytic therapy.		2008	2680258
minimizing the risk of oral aluminium exposure in chronic renal failure.		2008	2680268
mechanistic aspects of cytochrome p-450-hydroperoxide interactions: substituent effects on degradative pathways.		2007	2680387
national study on the utilization of prophylactic antibiotics in surgery, belgium, 1986.	during the last week of may 1986, a 1-week prospective study on antibiotic utilization in surgical patients was held in 104 (42%) of the 247 belgian acute care hospitals. all surgical patients with a post-operative stay of at least 3 days were studied, involving 3112 patients. each patient was observed for 7 days, starting from the day before surgery. antibiotics were administered to 71.9% of all patients; 21.9% received therapeutic antibiotics and 52.9% prophylactic antibiotics; 2.9% received b ...	2008	2680549
use of hybridoma immunoglobulin switch variants in the analysis of the protective properties of anti-lipopolysaccharide antibodies in escherichia coli k1 infection.	functional properties of rat immunoglobulins obtained from hybridoma isotype switch variants were studied in vivo in a rat model for neonatal bacterial sepsis. escherichia coli 018:k1, a common cause of human neonatal sepsis and meningitis, was injected intravenously into 6-day-old rats after incubation with 018-specific antibodies igm, igg1, igg2a, igg2b, igg2c, ige and iga. the clearance of bacteria treated with saline or ige was low, whereas monoclonal antibodies of other isotypes triggered h ...	1989	2680911
evaluation of some prognostic factors in small squamous cell carcinoma of the mobile tongue: a multicenter study in sweden.	in a retrospective study of 58 patients from all over sweden, treated for small squamous cell carcinoma of the mobile tongue (t1n0m0), different prognostic factors were evaluated. a partial glossectomy was performed as primary treatment in all patients. the cancer recurred in 28 (38%) of 58 patients. one of 7 patients with only local recurrence, and 9 of 14 with recurrence in the neck died of their disease. the relative survival rate was 77%. of the prognostic factors tested, tumor thickness was ...	2009	2681065
digit-muscle responses evoked from multiple intracortical foci in monkey precentral motor cortex.	1. the precentral motor cortex, including the anterior bank of the central sulcus of monkey (macaca fuscata), was systemically penetrated with microelectrodes to determine the spatial organization of the microexcitable cortical elements that can produce responses in digit muscles. 2. at 200-microns intervals on each electrode track, low-current intracortical microstimuli were delivered and the muscle responses evoked from four digit muscles were recorded. the responses, obtained with 5, 8, 15, a ...	1989	2681562
alpha 1-antitrypsin deficiency (pi sz) and biliary atresia.	we report an infant who presented at 2 days of age with conjugated hyperbilirubinemia. serological, radiographic, and surgical investigations revealed the concurrence of alpha-1-antitrypsin deficiency, protease inhibitor type sz, and extrahepatic biliary atresia.	2009	2681651
esophageal leiomyoma in children: two case reports and review of the literature.	leiomyoma of the esophagus is not uncommon in the adult population but is rarely seen in children; only 20 cases have been reported in the pediatric population. in this paper we describe two cases of esophageal leiomyoma in female patients aged 6 and 13 years and review previous reports. several differences were noted between the pediatric and adult population. the mean age in children is 14 years (range, 4 to 20 years). leiomyoma appears 1.71 times more often in females than in males. localized ...	2009	2681658
success of etched-metal bonded retainers with nonrigid connections: a clinical study.	the use of etched-metal bonded retainers in combination with conventional fixed retainers has been described in the literature. this design creates several potential problems that can be overcome by the use of an etched-metal bonded retainer with a nonrigid connector as described in this article. also presented are the preliminary results of a clinical study of 25 restorations that had been in place 13 to 45 months (average 22 months). the preliminary results are encouraging. no failures have be ...	2009	2681695
[poisoning by geromitra esculenta].	gyromitra esculenta (persoon ex fries) mushrooms have been responsible for severe intoxications and even deaths. clinical data are characterized primarily by vomiting and diarrhoea, and, afterwhile, by jaundice, convulsions and coma. the species of concern are mainly g. esculenta, g. fastigiata and g. gigas; nevertheless, recent advances in chromatography, biochemistry and toxicology have established that other species within the ascomycetes may prove also toxic. the toxins, i.e. gyromitrin (n-m ...	2009	2681713
gnrh peptides and regulation of the corpus luteum.		1989	2681738
mechanism of action of gnrh-induced oocyte maturation.		1989	2681744
comparison of direct immunofluorescent staining and an enzyme-linked immunoabsorbent assay for identifying chlamydia trachomatis in cervical and urethral specimens.	a direct fluorescent antibody (dfa) stain (microtrak, syva) and an enzyme-linked immunoabsorbent assay (chlamydiazyme, abbott) were used to detect chlamydial infection in 179 cervical specimens and 56 specimens obtained from the female urethra. chlamydiazyme, when compared with the dfa technique, revealed a high degree of correlation in these specimens (22 and 21 positive cervical specimens, respectively, and 7 each positive urethral specimens). since both techniques are readily available, inexp ...	1989	2681749
the failure of intravenous cyclophosphamide therapy in refractory idiopathic inflammatory myopathy.	eleven patients with idiopathic inflammatory myopathy refractory to treatment with corticosteroids and other immunosuppressive agents were treated with monthly intravenous cyclophosphamide (0.75-1.357 g/m2). six patients completed a full course of 7 infusions at which point only one patient met predefined criteria for improvement in both strength and function. five had modest improvement in strength but did not meet the criteria for improvement. all patients have subsequently required treatment ...	1989	2681763
the research arena of this symposium and an outlook for future treatment of osteoarthritis.	attention of researchers in the field of cartilage degradation in osteoarthritis is being focused on pathways of enzymic degradation and their control. whereas, it is unlikely that a precise cascade as in the complement and clotting systems will be found, a more loosely knit cascade is evolving in terms of mediators, activators, and inhibitors of enzymes, which degradate matrix stroma. structural changes in the proteoglycans are becoming clearly obvious with newer technologies, which can be visu ...	2009	2681765
biblical leprosy: a comedy of errors.		2009	2681774
fact and fashion: changing practices in child psychiatry.		2009	2681776
acute gluteal abscesses: injectable chloroquine as a cause.	one hundred and seven patients admitted to the casualty department with acute gluteal abscesses and surgically drained were studied. in 91 patients (85%) the abscess was a result of an intramuscular injection, of whom 71 patients (66%) had the abscess following a chloroquine injection (antimalarial). of those patients with an abscess following an intramuscular injection, in 64 patients (70%) a disposable syringe was used for injection of the drug and in 18% a boiled disposable was used. the inje ...	1989	2681814
first trimester bradycardia. a sign of impending fetal loss.	normal first trimester fetal heart rates rise from an average of 100 beats per minute (bpm) at 5 to 6 weeks to 140 bpm at 8 to 9 weeks. the heart rates of 65 consecutive first trimester fetuses between 5+ and 8+ weeks were measured to determine whether unusually slow first trimester fetal heartbeats are associated with a poor outcome. all five pregnancies in which heart rates were below 85 ended in spontaneous miscarriage. this study suggests that first trimester bradycardia may be associated wi ...	2009	2681826
[adenosquamous carcinoma and squamous cell carcinoma of the liver: a resected case and three autopsied cases].	a resected case and an autopsied case of an adenosquamous carcinoma and two autopsied cases of a squamous cell carcinoma of the liver are presented. with regard to the first case, a 58-year-old male underwent an operation, based on the diagnosis of a hypovascular hepatoma or a cholangioma. the resected material showed a nodular whitish gray tumor at the s4 region which histologically proved to be an adenosquamous carcinoma. in the two autopsied cases, found was a huge, grayish necrotic mass at t ...	2009	2681878
[cystic thyroid masses: ultrasonographic and pathologic correlation].	forty-nine patients with 63 cystic thyroid masses who had undergone preoperative sonography were retrospectively reviewed. 52 lesions (83%) were benign and others (17%) were malignant. among various sonographic findings of cystic thyroid masses, oval cystic lesions with polyp or dome like solid component projecting into the lumen were all diagnosed adenomatous goiter. irregular cystic structures with more than 2 cm finger like pedunculated mass extended into and/or out of the lumen were all diag ...	2009	2681887
histological changes in the airway after antigen inhalation challenge in asthma.		2009	2681901
lung cancer coexisting with bullae.	scattered reports have suggested the association of cancer with bullous disease. we report herein, two surgical cases of lung cancer arising from bullae. both the patients were males who smoked heavily and the generation of cancer was found simultaneously with the discovery of the bulla. at thoracotomy, it was found that the cancer had arisen from the firm, scarred and contracted area adjacent to the bulla wall. on the basis of this experience and review of the literature, it is suggested that p ...	2009	2681905
high-frequency ventilation experience: a rescue protocol for neonates with airleaks.		2009	2681914
[reca-independence of the process of amplification caused by the rs-1 sequence of vibrio cholerae].	the processes of amplification and deamplification of a plasmid dna segment flanked by direct repeats of rsi-sequence of vibrio cholerae and carrying the structural genes of cholera toxin inside the recombinant plasmid in e. coli cells have been studied. these processes determined by rsi-sequences are shown to take place independent of the reca-system of e. coli cells.	1989	2682220
the vestibulo-ocular reflex: is it an independent subsystem?	traditionally, the vestibulo-ocular reflex (vor) is described as a distinct, phylogenetically old, oculomotor subsystem, which serves to stabilize gaze direction. it is supposed to act as a stereotyped reflex with definite input-output relations, which can be measured by rotating a subject passively in darkness, and which are kept at a nearly ideal level by adaptive parametric adjustments. this paper argues that such a view of the vor may be not realistic: 1) the vor in darkness (especially in h ...	2009	2682929
corticosteroids in homeostasis.		2008	2683585
corticosteroids in homeostasis.		2008	2683585
vibrio cholerae non-o1 infection presenting as localized cellulitis.	vibrio cholerae non-o1 characteristically causes gastrointestinal illness but can occasionally be responsible for extra-intestinal infections. the authors report an unusual case of a man presenting with extensive cellulitis that did not improve with conventional antimicrobial therapy. vibrio cholerae non-o1 was later isolated from a cutaneous bulla. although he had severe hepatic cirrhosis, the infection remained confined to the cutaneous tissues and he was never bacteremic. he improved dramatic ...	1989	2683771
single-dose treatment of cholera with furazolidone or tetracycline in a double-blind randomized trial.	to evaluate single doses of 400 mg of furazolidone and 1 g of tetracycline given orally to patients with diarrhea due to vibrio cholerae, we studied 87 adults in a randomized, double-blind, placebo-controlled trial. all patients received intravenous fluids for rehydration and no other drugs. the total volumes of stool (mean +/- standard deviation) during a 6-day period after treatment were significantly smaller in the tetracycline group (10.5 +/- 8.6 liters) than in the furazolidone group (20.9 ...	1989	2684006
detection with synthetic oligonucleotide probes of nucleotide sequence variations in the genes encoding enterotoxins of escherichia coli.	we examined variations in the genes encoding heat-stable enterotoxin (st) and heat-labile enterotoxin (lt) in 88 strains of escherichia coli isolated from individuals with traveler's diarrhea to find suitable sequences for use as oligonucleotide probes. four oligonucleotide probes of the gene encoding st of human origin (stib or sth), one oligonucleotide probe of the gene encoding st of porcine origin (stia or stp), and three oligonucleotide probes of the gene encoding lt of human origin (ltih) ...	1989	2685027
volvulus of the gallbladder. report of two cases and review of the literature.	torsion or volvulus of the gallbladder is a rare cause of acute cholecystitis. although it has been reported in all age groups, it is most commonly seen in the elderly. with our increasingly aged population, it behooves the clinician to keep this entity in mind when treating the older patient with abdominal pain. we present two cases of torsion of the gallbladder and review the clinical and pathological aspects of this disease.	2009	2685538
[clinical significance of immunoscintigraphy for the diagnosis and treatment of gastrointestinal malignant tumors].	eighty-one immunoscintigraphy (is) studies in 80 patients with gastrointestinal malignancies were re-evaluated retrospectively to analyze accuracy and clinical impact of the is findings. selection of patients was based upon complete diagnostic records and a clinical follow-up of at least 6 months. the 3 antibody preparations used (99m-tc labelled complete anti-cea antibodies (bw 431/26), 111-in labelled f(ab')2-fragments against cea (bw 431/31), and a mixture of 131-i labelled f(ab')2-fragments ...	1989	2685690
[the development of a quantitative method for the in vivo determination of the adhesive activity of vibrio cholerae].	the dynamics of the distribution and adhesion of v. cholerae in the intestine of suckling rabbits has been studied. the quantitative method for the in vivo determination of the adhesive activity of v. cholerae has been developed with the use of suckling rabbits as an experimental model. the method may be used for the determination of v. cholerae virulence and the pathogenesis of cholera.	1989	2686301
[quantitative evaluation of the adhesive activity of vibrio cholerae with various degrees of virulence].	in the studies on the evaluation of v. cholerae adhesion on suckling rabbits by our method, the adhesive activity of the vibrios has been found to be directly related to their virulence. this method may be used as an additional test for the differentiation of virulent and avirulent v. cholerae.	1989	2686311
specifics of specificity and sensitivity.		2008	2686458
specifics of specificity and sensitivity.		2008	2686458
[the mechanism of digging in arvicola terrestris and spalax ehrenbergi: functional and evolutional studies].	the cineradiographic study of the digging modalities in arvicola terrestris and spalax erenbergi showed important convergences in the mechanisms used by both species. head and incisors are the burrowing tools, acting as a "scraping-shovel" in spalax and as a "scratching-shovel" in arvicola. they are moved forward by a force originated by the pressure of the hind limbs against the ground, and transmitted through the vertebral axis. the myological study of these species revealed the increase of th ...	2008	2686491
[the mechanism of digging in arvicola terrestris and spalax ehrenbergi: functional and evolutional studies].	the cineradiographic study of the digging modalities in arvicola terrestris and spalax erenbergi showed important convergences in the mechanisms used by both species. head and incisors are the burrowing tools, acting as a "scraping-shovel" in spalax and as a "scratching-shovel" in arvicola. they are moved forward by a force originated by the pressure of the hind limbs against the ground, and transmitted through the vertebral axis. the myological study of these species revealed the increase of th ...	2008	2686491
the significance and scope of reproductive tract infections among third world women.	due to biomedical, behavioral and societal factors, reproductive tract infections are widespread in the third world. without early diagnosis and accurate therapy, their complications severely compromise women's health, fertility and productivity; infant health and survival; and the effectiveness of family planning programs. clinicians and public health planners can address these treatable syndromes through research and services in socially acceptable settings including family planning, prenatal ...	2009	2686703
mechanisms of resistance in anaerobes and new developments in testing.	anaerobic bacteria currently demonstrate increased resistance to antimicrobial agents, primarily by the production of beta-lactamase. a number of species of bacteroides, most notably those in the bacteroides fragilis group, produce these enzymes. a few species of fusobacterium and clostridium produce beta-lactamase as well. fortunately, this mechanism of resistance is readily overcome by administering beta-lactamase inhibitors coupled with a beta-lactam antibiotic that would otherwise be inactiv ...	1989	2686914
glasgow's temperance story: changing approaches towards the control of alcohol abuse.	this article gives an account of the growth and eventual decline of glasgow's temperance movement from its beginnings in the early part of the 19th century, to the present day. the article focuses on the changing rhetoric, aims and practice of the various organisations within the glasgow temperance movement. these shifts, from individual persuasion to moves for government legislation, are analysed in relation to the social and political conditions of their time. the article concludes by drawing ...	2009	2687207
methyl-directed repair of frameshift heteroduplexes in cell extracts from escherichia coli.	the methyl-directed dna repair efficiency of a series of m13mp9 frameshift heteroduplexes 1, 2, or 3 unpaired bases was determined by using an in vitro dna mismatch repair assay. repair of hemimethylated frameshift heteroduplexes in vitro was directed to the unmethylated strand; was dependent on muth, mutl, and muts; and was equally efficient on base insertions and deletions. however, fully methylated frameshift heteroduplexes were resistant to repair, while totally unmethylated substrates were ...	1989	2687237
regulator and enzyme specificities of the tol plasmid-encoded upper pathway for degradation of aromatic hydrocarbons and expansion of the substrate range of the pathway.	the tol plasmid upper pathway operon encodes enzymes involved in the catabolism of aromatic hydrocarbons such as toluene and xylenes. the regulator of the gene pathway, the xylr protein, exhibits a very broad effector specificity, being able to recognize as effectors not only pathway substrates but also a wide variety of mono- and disubstituted methyl-, ethyl-, and chlorotoluenes, benzyl alcohols, and p-chlorobenzaldehyde. benzyl alcohol dehydrogenase and benzaldehyde dehydrogenase, two upper pa ...	1989	2687253
sodium-transport nadh-quinone reductase of a marine vibrio alginolyticus.	the respiratory chain of a marine bacterium, vibrio alginolyticus, required na+ for maximum activity, and the site of na+ -dependent activation was localized on the nadh-quinone reductase segment. the na+ -dependent nadh-quinone reductase extruded na+ as a direct result of redox reaction. it was composed of three subunits, alpha, beta, and gamma, with apparent mr of 52, 46, and 32 kda, respectively. the reduction of ubiquinone-1 to ubiquinol proceeded via ubisemiquinone radicals. the former reac ...	1989	2687259
expression of the catalytic subunit of camp-dependent protein kinase in escherichia coli.	a cdna clone for the catalytic subunit of murine camp-dependent protein kinase was placed into two expression vectors, plws-3 and plsw-4. for plws-3, the entire coding region of the catalytic subunit was inserted into the ndei site of pt7-7 under the control of the t7 promoter. plws-4 contains a polycistronic transcript under control of the lac uv5 promoter encoding for the type i regulatory subunit followed by the catalytic subunit. significant expression was achieved with plws-4 in escherichia ...	1989	2687267
complement component c1q enhances invasion of human mononuclear phagocytes and fibroblasts by trypanosoma cruzi trypomastigotes.	internalization and infectivity of trypanosoma cruzi trypomastigotes by macrophages is enhanced by prior treatment of parasites with normal human serum. heating serum or removing c1q from serum abrogates the enhancement, but augmentation of attachment and infectivity is restored by addition of purified c1q to either serum source. although both noninfective epimastigotes (epi) and vertebrate-stage tissue culture trypomastigotes (tct) bind c1q in saturable fashion at 4 degrees c, internalization b ...	1989	2687332
spontaneous motor activity in healthy volunteers after single doses of haloperidol.	video recordings of the spontaneous motor activity of 6 healthy volunteers after treatment with 0.75 mg haloperidol i.v., or placebo, were transcribed into a time-series protocol of motor behaviour. characteristic changes seen after the injection of haloperidol consisted in a reduction of the motility of the extremities and prolongation of the phases of both movement and immobility of the head. the tested dose of haloperidol induced a distinct rise in serum prolactin and sedation, but had no eff ...	2009	2687356
fluorouracil filtering surgery study one-year follow-up. the fluorouracil filtering surgery study group.	two hundred thirteen patients participated in the fluorouracil filtering surgery study, a randomized clinical trial, to determine the efficacy and safety of subconjunctivally injected 5-fluorouracil after filtering surgery in eyes with poor prognoses. twenty-eight (27%) of the 105 eyes in the 5-fluorouracil group and 54 (50%) of the 108 eyes in the standard group were classified as failures, defined by reoperation for control of intraocular pressure during the first year or an intraocular pressu ...	2009	2688428
a mutation in the dam gene of vibrio cholerae: 2-aminopurine sensitivity with intact gatc methylase activity.	vibrio cholerae mutants sensitive to 2-aminopurine (2ap) but with dna adenine methylase activity similar to parental cells have been isolated. the mutant strains were sensitive to ultraviolet light (uv), methyl methane sulphonate (mms) and 9-aminoacridine. the spontaneous mutation frequency of the mutants were not significantly affected. attempts to isolate dam v. cholerae cells by screening 2ap sensitive cells have not been successful. all the mutant phenotypes could be suppressed by introducin ...	1989	2688642
assay for sialidase using erythrocytes and peroxidase-labeled peanut lectin.	a rapid and sensitive sialidase assay method based on peroxidase-labeled peanut lectin (pna) binding to desialylated erythrocyte is described. formalinized sheep erythrocytes were used both as a stable substrate for sialidase and as a target for the lectin. in the case of sialidases from vibrio cholerae and arthrobacter ureafaciens, a linear relationship was observed between the amount of peroxidase-labeled pna bound to erythrocytes and the enzyme amount. binding of the lectin to sialidase-treat ...	1989	2688936
cholera on the louisiana gulf coast: historical notes and case report.	a 67-year old woman was brought by ambulance to the hospital because of syncope and collapse. forty-eight hours prior to the admission she ate some crabs with her husband. the morning of admission she awakened with massive, watery diarrhea followed by vomiting and shock. she was admitted to the intensive care unit with hypotension and bradycardia. she was resuscitated after a large volume of fluid was administered. approximately 22 liters of fluids were administered in 24 hours. stool cultures g ...	1989	2689545
antibiotic resistance in the tropics. 1. the genetics of bacterial ampicillin resistance in tropical areas.	ampicillin and its derivatives are the most widely used beta-lactam antibiotics throughout the world. ampicillin resistance in gram-negative bacteria is usually manifested by plasmid-encoded beta-lactamases, which hydrolyse the beta-lactam ring of the antibiotic. there are at least 30 different plasmid-encoded beta-lactamases but almost all of them are found very infrequently. the one exception is the tem-1 beta-lactamase which is found wherever transferable ampicillin resistance emerges and acc ...	1989	2690414
characterization of toxigenic vibrios isolated from the freshwater environment of hiroshima, japan.	the occurrence and characterization of toxigenic vibrios in surface water and sediment samples of the fresh water environment of the ohta river were studied. the membrane filter, pad preenrichment technique, followed by the placement of membranes onto thiosulfate citrate-bile salt-sucrose agar, was used for the enumeration of total vibrios. qualitative examination of pathogenic vibrios was also attempted. in addition, a survey was conducted to determine the incidence of clostridium botulinum in ...	1989	2690736
management of subarachnoid hemorrhage in the critical care unit.	subarachnoid hemorrhage from a ruptured intracranial saccular aneurysm is associated with a high rate of morbidity and mortality. most complications occur two to three weeks after the initial hemorrhage. the key to minimizing morbidity and mortality is early and aggressive intensive-care management. the cleveland clinic neurosurgical intensive care unit approach is reviewed.	2009	2691116
improvement of estradiol enzymoimmunoassay, using a monoclonal antibody and an avidin/biotin amplification system.	a microtitre plate enzyme immunoassay for estradiol, using a purified monoclonal antibody covalently bound to peroxidase and a small amount of immobilized immunogen, was optimized. decreasing the antibody concentration to 2 x 10(-10) m (kd/5) gave optimum estradiol detectability. the enzymatic signal was, however, very low in this assay. a 14-fold enhancement could be obtained using an avidin-biotin system in which several biotin molecules are conjugated with the antibody, providing multiple sit ...	2009	2691527
lipoprotein disorders in diabetes mellitus.		2009	2691606
[gene structure and gene expression regulation of renin and angiotensinogen and processing of the precursors].		2009	2691726
[principle, method, and application for the production of peptide hormones using genetic engineering].		1989	2691727
exercise training produces changes in free and conjugated catecholamines.	in dogs the concentrations of conjugated dopamine in plasma have previously been shown to increase after exercise training. this study was done to determine whether conjugated norepinephrine and epinephrine also increase. fifteen dogs were randomly divided into training (n = 8) or sedentary (n = 7) groups. all dogs were exercised acutely for 5 min at 4 mph with a 12% grade, following a 3-min warm-up, before and after either a 12-wk training or a 12-wk sedentary period. free and conjugated catech ...	1989	2691817
positive and negative liposome-based immunoselection techniques.		2009	2691860
intraperitoneal chemotherapy in peritoneal malignancy: impact of intensive system care on practicability.	in a group of 31 patients a port-a-cath-system for intraperitoneal chemotherapy was installed. from 23 evaluable patients 9 showed a tumor remission, but only 1 was a patient with gastrointestinal carcinoma. all others were patients with ovarial carcinoma. the median survival rate of all patients was 9 months after implantation of the intraperitoneal catheter. 50% of all patients with gastrointestinal carcinoma died within the first 6 months, only 1 of 11 patients with ovarial carcinoma died in ...	2009	2692376
ontogeny and regulation of drug metabolism in humans. phase i: monooxygenases.	most data concerning the development and regulation of cytochrome p-450-dependent monooxygenases were obtained in experimental animals, especially rats, by two successive approaches: first, the assay of total liver cytochrome p-450 and of related monooxygenase activities; then, more recently, the immunoquantification of molecular forms of cytochrome p-450, and the estimation of corresponding mrnas with nucleic acid probes. results were compared, before and after birth, in untreated animals, and ...	1989	2693005
empirical antibiotics for febrile neutropenic cancer patients.	the empirical institution of broad spectrum antibiotics for febrile neutropenic cancer patients has become standard medical practice. traditionally, the antibiotics consisted of a combination of agents selected to maximize activity against the most commonly isolated pathogens, and often employed agents with synergistic antimicrobial activity. recent additions to the antibiotic armamentarium, however, have provided single agents with equivalent spectra of activity, thus potentially allowing a 'mo ...	2009	2693109
falciparum malaria--present day problems. an experience with 425 cases.	clinical details and present day problems encountered in 425 cases of falciparum malaria (pf) are reported. 10.11% had taken chloroquine prior to reporting to us. parasitic count done in 23.05% cases lacked correlation with severity of disease. pattern of fever varied markedly but 5.4% were afebrile throughout and presented only with bodyache and malaise. apyrexial spell was noted in 5.64%. 28.70% had typical facial looks of anaemia and sallow complexion. cerebral symptoms were noted in 3.05%. o ...	1989	2693436
scoliosis.	four basic criteria are important when determining which diseases are amenable to detection and treatment by screening: 1) the diagnostic test used must be highly sensitive, 2) the disease should cause substantial morbidity or mortality, 3) early detection and treatment should eliminate the disease or prevent its progression, 4) the incidence of the disease should be high enough to warrant the utilization of time, resources, and money. a review of three large screening studies evaluating the det ...	2007	2693581
[various approaches to studying molecular-genetic mechanisms of low-temperature adaptation of microbial populations].	the effect of biologically low temperature (12 degrees c) on the parameters of microbial population such as survival, catalase activity and its isoenzyme spectrum have been investigated on the models of escherichia coli and yersinia pseudotuberculosis. the quantity of nucleic acids, plasmid spectrum and temperature effect on the level of plasmid dna spiralization were studied under these conditions. the process of molecular genetic adaptation of bacterial populations having the broad temperature ...	1989	2693957
[70 years nursing school innsbruck].		2009	2694061