Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| lipids and slow viruses: comparison of measles and sspe virions. | 1976 | 937121 | |
| antibodies to vaccinia and measles viruses in multiple sclerosis patients. | a virologic comparison was made of 144 patients with multiple sclerosis, 34 of their healthy siblings, and 40 patients with other neurologic diseases (ond). antibodies in serum and cerebrospinal fluid (csf) to vaccinia and measles viruses were measured, and these were correlated in the multiple sclerosis patients with the clinical characteristics of their disease. the csf antibody to vaccinia virus was more frequent and at a higher titer in multiple sclerosis patients than in either control grou ... | 1976 | 938265 |
| [subacute sclerosing panencephalitis. report of 31 cases (author's transl)]. | we present 31 cases of subacute sclerosing panecephalitis from the epidemiologic, clinical, electroencephalographic, laboratory and anatomopatological point of view. psychical disorders (51,59%) and generalized convulsive fits (19,45%) stand out as a first cause of consultation. a high visual hallucinatory incidence (35,48%) was observed. repeated complexes were of great value for the early diagnosis as well as the high titers of measles-virus antibody in the serum and cerebrospinal fluid for th ... | 1976 | 942129 |
| cytotoxic activity of peripheral blood lymphocytes against hela cells persistently infected with measles virus: depressed capacity in multiple sclerosis. | 1976 | 944900 | |
| [immunologic response and reactions to vaccination in children vaccinated against measles. iii. persistence of measles antibodies in children vaccinated in 1972]. | 1976 | 945592 | |
| booster vaccination with further live attenuated measles vaccine. | revaccination with live attenuated measles vaccine was evaluated in a large group of children to determine (1) if protective antibody to measles infection could be augmented and (2) after what interval will the revaccination yield optimal results. the rate of decline in measles hemagglutination-inhibition (hi) antibody was observed to be directly related to the time interval since the previous vaccination, and individuals with declining titers became increasingly responsive to revaccination with ... | 1976 | 945997 |
| letter: measles immunity and revaccination. | 1976 | 946524 | |
| transient appearance of oligoclonal immunoglobulins and measles virus antibodies in the cerebrospinal fluid in a case of acute measles encephalitis. | acute measles encephalitis with severe sequelae in a 25-year-old man was studied. a transient appearance of oligoclonal igg in cerebrospinal fluid and of intrathecally produced measles antibodies was found during 2 months after the onset of the disease. on the basis of this finding of local hyperimmunization it is proposed that in the case studied the measles virus infection may have been directly responsible for the disease process in the central nervous system. | 1976 | 947643 |
| [role of measles virus infection in patients with multiple sclerosis]. | 1976 | 951335 | |
| defective bud formation in human cells chronically infected with subacute sclerosing panencephalitis virus. | human prostate cells chronically infected with the mantooth strain of subacute sclerosing panencephalitis (sspe) virus multiply normally, fuse only occasionally to form giant cells, and yet have twisted intracytoplasmic nucleocapsids. these cells are able to support replication of vesicular stomatitis virus, although they release only small amounts of sspe virus. to determine why carrier cells do not produce virus, they were examined with techniques for surface replication, freeze-fracturing, an ... | 1976 | 957482 |
| fine structural changes in human astrocyte carrier lines for measles virus. | 1976 | 958474 | |
| measles virus-induced migration inhibition in vitro of leukocytes from patients with multiple sclerosis. | the migration inhibition in vitro induced by measles virus material on leukocytes from 17 patients with multiple sclerosis (ms) was compared with that of 8 patients with various other central nervous system diseases and that of 12 healthy blood donors. significant differences could not be demonstrated. the results do not indicate that ms patients' leukocytes show an altered behaviour to measles virus material in the migration inhibition test. | 1976 | 959780 |
| the properties of uv-inactivated measles virus. | 1976 | 963607 | |
| variation in thermostability of measles virus. | 1976 | 966395 | |
| [atypical clinical patterns of subacute sclerosing encephalitis]. | 1976 | 967601 | |
| electron microscopy of mitotic cells in a measles-carrier human cell line. | 1976 | 977380 | |
| salt-dependent haemagglutinating measles virus in s.s.p.e. | two strains fo s.s.p.e. virus show both haemagglutinin and salt-dependent haemagglutinin. these properties are associated with distinct plaque forms within each strain. the existence of salt-dependent strains in wild-type measles virus suggests that they should be found in the early isolates of all strains of s.s.p.e. | 1976 | 978182 |
| studies on the persistent infection of measles virus in hela (hela/mv) cells. vi. electron microscopic observation of hela/mv cells. | 1976 | 978840 | |
| [subacute sclerosing panencephalitis (sspe), an unusual and therefore often unrecognized disease]. | 1976 | 980139 | |
| severe measles-associated pneumonia treated with assisted ventilation. | measles-associated pneumonia, which was severe enough to require mechanical ventilation, caused a mortality of 64%. the main indications for special respiratory care were severe infection and hypoxaemia. complications of the disease occurred in 78% of the patients. the commonest were anaemia, enteritis and cardiac failure, and they contributed to the grave prognosis. viral pneumonia was present in most of the patients who died; superinfection was rare. the characteristics of measles virus was pr ... | 1976 | 982215 |
| [incomplete digeorge syndrome (author's transl)]. | a newborn with multiple malformations, recurrent infections and hypocalcemic tetany is presented. the malformations included: facial asymmetry, micrognathia, epicantus, low set nose, peculiar ears, club-feet and heart disease. the immunologic work-up disclosed a cellular immunodeficiency, but normal humoral immunity, and a diagnosis of "incomplete digeorge syndrome" was made. no thymus, nor parathyroid glands were found at autopsy. the disagreement between the analytical data and the pathologica ... | 1976 | 984606 |
| growth of rubella, measles and mumps viruses in rat fetus. | 1976 | 986487 | |
| the effect of levamisole on cellular immunity in multiple sclerosis. | the lymphocyte stimulation test has been standardized in a normal human population using four virus cell-associated antigens (vcaa): human embryonic lung cells infected with the lec and norrby strains of measles virus, mumps virus, and vaccinia virus. following 1 week of treatment with the immunopotentiating drug levamisole, a group of multiple sclerosis (ms) patients was found to have increased lymphocyte stimulation responses toward vcaa and increased delayed hypersensitivity responses towards ... | 1976 | 991460 |
| measles antigen in multiple sclerosis: identification in the jejunum by immunofluorescence. | 1976 | 994704 | |
| measles virus-induced migration inhibition of human leukocytes in vitro: an expression of cell-mediated immunity? | attempts were made to establish measles virus-induced migration inhibition of human leukocytes as an in vitro test of cell-mediated immunity to the virus. crude material from cell cultures infected with two different strains of measles virus was used as antigen in the capillary modification of the test. both virus preparations induced migration inhibition. incubation with puromycin indicated that the inhibition was dependent on protein synthesis, which has been regarded as a characteristic featu ... | 1976 | 996451 |
| oligoclonal measles virus-specific igg antibodies isolated from cerebrospinal fluids, brain extracts, and sera from patients with subacute sclerosing panencephalitis and multiple sclerosis. | measles virus-specific antibodies were isolated from sera, cerebrospinal fluids (csf), and brain extracts of patients with subacute sclerosing panencephalitis (sspe) and multiple sclerosis (ms) by absorption with measles antigens and subsequent acid elution of the antigen-antibody precipitates. electrophoretically homogeneous measles antibodies were isolated from csf or brain extracts in five patients with sspe and in five out of seven patients with ms. homogeneous igg antibodies were also demon ... | 1976 | 996452 |
| application of microassay technique in cell-mediated immunity to measles virus infection. | a microassay technique for the detection of cell-mediated immunity to measles virus is described. lymphocytotoxicity of peripheral blood lymphocytes was determined employing the percent reduction of target cells surviving on the microtissue culture plate. simultaneously, subpopulation of peripheral blood lymphocytes was also measured. significant measles specific cytotoxicity was only demonstrated in the subjects with prior histories of measles but no reactivity was observed in the children with ... | 1976 | 996848 |
| neurotropism in new born hamsters of plaque purified measles virus clones. | 1976 | 999517 | |
| circular and elongated linear forms of measles virus nucleocapsid. | 1976 | 1004581 | |
| rna homology between subacute sclerosing panencephalitis and measles viruses. | 1976 | 1004582 | |
| [multiple sclerosis with reduced and with normal levels of complement in the blood. clinical and genetic correlation]. | the authors describe the results of immunological assay of complement factors c3, c4 (the usual path of activation of complement) and of b factor (the alternate path of activation) in 61 multiple sclerosis patients not receiving corticoids, 52 normal controls and 217 patients with other neurological disorders. hypocomplementaemia (fall in factor c3 related to a fall in total haemolytic activity) was found in 29.5 p. 100 of the patients not on corticotherapy at the first assay, and in 36 p. 100 o ... | 1976 | 1006010 |
| reduced transplantability of syngenic mouse tumors superinfected with membrane viruses in nu/nu mice. | transplantability of mouse tumors superinfected with various kinds of membrane viruses was investigated in syngeneic hosts. methylcholanthrene-induced fibrosarcomas in balb/c mice, meth a, and in c57bl/6 mice, bmt-, superinfected with friend lymphatic leukemia virus in mice given neonatal injection of the virus, grew more slowly than uninfected tumors. the retardation of growths was not observed in mice that had been given injections of the virus at birth. similarly, meth a and a hepatoma in c3h ... | 1976 | 1006777 |
| [pathology and immune lysis of cells infected with measles virus isolated from subacute sclerosing panencephalitis]. | the si strain isolated from a patient with subacute sclerosing panencephalitis like reference measles virus strains was shown to induce in cell cultures formation of symplasts and spindle-shaped cells, cytoplasmic and intranuclear inclusions, pathology of mitosis, appearance of intracellular and surface virus-induced antigens. the presence of the latter caused cell cytolysis under the effect of measles immune sera and complement. | 1976 | 1007218 |
| [measles antibody in patients with multiple sclerosis at different stages of the disease]. | sixty-nine patients with multiple sclerosis from 12 to 53 years of age were examined. the titre of measles antibody in the blood serum (geometric mean) was 9.0 log2 in the patients and 5.1 log2 in normal subjects of the control group. the antibody titre was found to depend upon the stage of the disease: the sera collected in the period of remission had a titre of 7.3 log2, and those collected in the exacerbation stage 10.7 log2. nineteen patients were examined both during remission and at the ti ... | 1976 | 1007227 |
| long-term persistence of antibody following enders' original and more attenuated live measles virus vaccine. | 1976 | 1013156 | |
| measles and the immune system. | 1976 | 1017310 | |
| events following the infections of enucleate cells with measles virus. | the development of measles virus (edmonston) and sspe measles virus (horta-barbosa) has been examined in enucleate bsc 1 cells. new antigen synthesis in measles virus infected enucleate cells has been demonstrated by fluorescent antibody, by the formation of extensive syncytia from enucleate cells alone and by analysis of polypeptide formation by polyacrylamide gel electrophoresis. all polypeptides formed in nucleate cells were also present in enucleate cells but the amount synthesized was reduc ... | 1976 | 1018171 |
| purification of host dna synthesis-suppressing factor (dsf) produced by infection with measles virus. | host dna synthesis-suppressing factor (dsf) produced into culture fluid of cloned hela cells (hela c-9) infected with a small plaque variant of toyoshima strain of measles virus was purified by precipitation with ammonium sulfate, chromatography on cm-cellulose and deae-cellulose, and gel-filtration on sephadex g-100 and g-200. the specific activity of the finally purified dsf was 302 units/mg of protein representing approximately 300-fold purification. the molecular weight of dsf was estimated ... | 1976 | 1018343 |
| sero-epidemiological study of measles virus infection in and around chandigarh. | 1976 | 1024074 | |
| [strategy of persistence (facts, hypotheses)]. | the universal phenomenon of virus persistence is considered to be a regular phenomenon primarily meeting the interests of the host. examinations of 1112 patients with various diseases of the nervous system revealed a certain dependence of macroglobulin measles antibody upon the character of the disease and the intensity of demyelinization process. these data do not suggest the etiological role of the persisting measles virus in the genesis of multiple sclerosis and a large group of other nervous ... | 1976 | 1025914 |
| [effect of infectious factors on human and animal cytogenetic structures]. | the analysis of blood leucocyte chromosomes has been carried out on 60 patients with different infectious diseases (influenza, measles, scarlet fever, and disentery), and on 47 patients immunized against measles, tick-born encephalitis, typhoid fever and brucellosis. the mutagenic influence of viruses on the genital cells of mice and on the human somatic cells in vitro was studied. both viruses and bacteria appeared to be able to bring about different breaks in human and animal cells. | 1976 | 1027162 |
| use of human diploid cell mrc-5, for production of measles and rubella virus vaccines. | a further attenuated strain of measles virus, called aik strain, developed by makino and his colleagues at the kitasato institute, tokyo, was adapted to human diploid cells (hdc), mrc-5. in a field trial it was found that this strain initiates a low rate of clinical reactions and 100% seroconversion in vaccines. an attenuated strain of rubella virus, called takahashi strain, isolated by shishido at the national institute of health, japan, was also adapted to hdc, mrc-5. brief details of producti ... | 1976 | 1031692 |
| cytoskeletal control of surface membrane mobility. | cytochalasin b induced redistribution of actin microfilaments into a bulge of the cytoplasm, bringing cell-surface elements to the corresponding surface area. this process was reversible, inhibited by colchicine and enhanced by antibodies to cell-surface antigens. | 1976 | 1034208 |
| the mechanisms of appearance of viral glycoproteins at the cell surface membrane. | 1976 | 1036289 | |
| development of a diploid cell line from fetal calf lung for virus vaccine production. | details of isolation and replication of a fetal calf diploid cell (fcdc) is given. from the karyological point of view, the fairly large number of chromosomes existing in metaphase spreads made counting rather tedious. lack of practical classification was another problem which made reference to individual chromosomes difficult. by increasing the population doubling of this cell, a tendency of telocentric chromosomes to undergo centric fusion was observed. susceptibility of fcdc to different viru ... | 1976 | 1036404 |
| sspe-like inclusion body disorder in treated childhood leukemia. | clinico-pathological report on a boy with cytostatically treated leukemia, dying with cerebral symptoms after passing clinical measles 10 weeks before death. at autopsy, numerous nuclear inclusion bodies in glial and nerve cells were found. by electron microscopy, nuclear inclusions appeared as loosely arranged smooth tubules, corresponding to paramyxovirus nucleocapsids. frequently, cytoplasmic changes appeared too, consisting of incomplete tubular structures and an abundant dense "fuzzy" mater ... | 1975 | 1057844 |
| measles virus-specific igd antibodies in patients with subacute sclerosing panencephalitis. | indirect immunofluorescent analysis revealed that sera from five patients with subacute sclerosing panencephalitis possessed igd antibodies directed against measles virus components in persistently infected hela cells. igd levels in these sera were within the normal range. control studies indicated that the reaction was specific for measles virus. the detection of igd measles antibodies in these patients suggested that igd may be involved in the pathogenesis of this viral disease. | 1976 | 1063410 |
| atypical measles infections in leukaemic children on immunosuppressive treatment. | one case of giant-cell pneumonia and two of encephalopathy, all due to measles infection in children in leukaemic remission on immunosuppressive treatment, were seen recently. the clinical syndromes were variable and atypical and the antibody responses unpredictable. conventional doses of pooled immunoglobulin failed to protect the two children to whom it was given. degeneration rather than inflammation seems to characterise the encephalopathy in immunosuppressed children infected with measles v ... | 1976 | 1064463 |
| [slow-virus "encephalitis" following measles in a child with cytostatically-treated leukaemia (author's transl)]. | a child with acute infantile lymphoblastic leukaemia in remission after cytostatic therapy contracted apparently uncomplicated measles. 8 weeks later, an acute neurological syndrome developed, which led to death within 2 weeks. at autopsy, a peculiar type of inclusion body "encephalitis" almost without signs of inflammatory infiltration was found. electron microscopic examination showed changes of paramyxovirus infection, which were attributable to slow measles virus disease of the cns. there wa ... | 1975 | 1065146 |
| unusual encephalitic illnesses in a child with acute leukaemia in remission: possible role of measles virus and toxoplasma gondii. | we report a girl who developed an encephalitic illness with visual loss after two years treatment for acute lymphoblastic leukaemia. the visual loss was found to be due to bilateral macular degeneration. she later developed radiological evidence of intracranial calcification and temporal lobe epilepsy. a second episode of encephalitis occurred when she had been off all antileukaemic treatment for three years and this left her with a right hemiparesis. investigation suggested involvement with bot ... | 1976 | 1069915 |
| editorial: retrobulbar neuritis revisited. | 1975 | 1078940 | |
| measles virus receptor on human t lymphocytes. | 1975 | 1079923 | |
| rubella antibody levels in juvenile rheumatoid arthritis. | increased rubella antibody titres have been reported in patients with juvenile rheumatoid arthritis (jra) and it has been suggested that rubella virus may be of importance in the aetiology or pathogenesis of the disease. in the present study, rubella and rubeola antibody titres in 85 patients with jra were compared to age- and sex-matched controls. 41% of the patients did not have rubella antibody, but the geometric mean titre of those with jra who had antibody was slightly higher than that of t ... | 1975 | 1081377 |
| [separation of antirubella igm antibodies by affinity chromatography]. | the separation of igm globulins by affinity chromatography has been used for serodiagnosis of primary infections with rubella or measles virus. igm antibody activity levels are similar to those obtained when the separation has been performed by ultracentrifugation. the results of 50 cases examined by the two separation methods are in agreement. however, affinity chromatography is more specific than gel filtration methods and requires a smaller amount of serum. the anti-human igm globulins, coval ... | 1975 | 1081412 |
| replication and persistence of measles virus in defined subpopulations of human leukocytes. | replication of edmonston strain measles virus was studied in several human lymphoblast lines, as well as in defined subpopulations of circulating human leukocytes. it was found that measles virus can productively infect t cells, b cells, and monocytes from human blood. these conclusions were derived from infectious center studies on segregated cell populations, as well as from ultrastructural analyses on cells labeled with specific markers. in contrast, mature polymorphonuclear cells failed to s ... | 1975 | 1081602 |
| rosette-forming lymphocytes and measles vaccination. | 1976 | 1082019 | |
| replication of measles virus in continuous lymphoid cell lines. | the replication of measles virus was studied in a t cell-like line, molt-4, and a b cell-like line, raji. both cell lines supported measles virus replication. the infected lymphoid cells were assayed for infectious virus and expression of measles antigens at timed intervals up to 84 hr after inoculation. at time 0, after a 2-hr adsorption period at 4 degrees c, both cell lines produced a maximum of 3% infectious centers and up to 22% antigen-positive cells. eventually all cells in both populatio ... | 1976 | 1082905 |
| lymphocyte-mediated cytotoxicity to viruses in patients with multiple sclerosis: presence of a blocking factor. | 1976 | 1084246 | |
| trial of a reduced dose of measles vaccine in nigerian children. | to evaluate the effectiveness of measles vaccine in reduced dosage, schwarz live, further attenuated measles virus vaccine was given in various doses by jet injector to 967 seronegative children aged 7-30 months in rural villages in the northwest state of nigeria. for children over 12 months of age, reducing vaccine virus dosage by 40%, 60%, or 80% led to progressive and statistically significant reductions in the seroconversion rates from 89% in children receiving the full dose to a minimum val ... | 1976 | 1086728 |
| [behavior of hemagglutination-inhibiting antibodies against measles and rubella in a group of children with chronic hepatitis]. | the authors studied the amount of anti-measles and anti-rubella heteroantibodies during chronic hepatitis and the possible role of these antibodies in eliciting and maintaining the hypergammaglobulinemic picture, characteristic of this morbid condition. the results they obtained in an almost exclusively pediatric case-list (37 cases) show, whenever the contact with these viruses (measles and rubella) occurred, a percentage of subjects with comparatively higher levels among chronic liver patients ... | 1976 | 1088074 |
| chromosome aberrations in cells infected with various strains of measles virus. | the incidence of chromosome fragmentation and/or breakage has been studied in cultured human embryonic diploid cells infected with different wild and vaccinal strains of measles virus. it seemed that for wild strains the mean incidence of fragmentation was two times higher, that of breakage two times lower than for the vaccinal strains. | 1975 | 1089353 |
| demonstration of in vitro lymphocyte-mediated cytotoxicity against measles virus in sspe. | patients with subacute sclerosing panencephalitis (sspe) are presumed to lack specific cellular immunity against measles virus. in order to test this hypothesis in vitro, the interaction between peripheral lymphocytes and measles virus-infected tissue culture cells was investigated in 10 sspe patients. human fibroblasts, either uninfected or carrying a persistent measles virus infection, were labeled with 51cr and incubated with lymphocytes for 18 to 20 hr in the absence of antibody and compleme ... | 1975 | 1089723 |
| characterization of measles virus-specific cytotoxic antibodies by use of a chronically infected cell line. | the complement-dependent cytotoxic effects of measles virus specific antibodies on a chronically infected cell line were studied by a microcytotoxicity assay. cell damage was determined by trypan blue staining. monospecific antisera against the hemagglutinin (ha) and the hemolysin (hl) of the virus were both cytotoxic. rabbits, immunized with measles virus, developed cytotoxic antibodies in parallel with the appearance of antibodies against the measles virus ha and hl. human sera with high antib ... | 1975 | 1089724 |
| subacute sclerosing panencephalitis virus in immunosuppressed adult hamster. | a hamster-adapted subacute sclerosing panencephalitis agent (hbs virus) produced a subclinical, nonlethal, and cell-associated encephalitis after intracerebral inoculation of adult hamsters. when adult hamsters were immunosuppressed by intraperitoneal injections of rabbit origin anti-hamster lymphocyte serum for varying periods of time before and after intracerebral challenge with hbs virus, more than 50 per cent died in all experiments. large titers of cell-free virus developed acutely in all a ... | 1975 | 1089839 |
| molecular pathogenesis of systemic lupus erythematosus. | the study of patients with systemic lupus erythematosus revealed the close association of the disease with measles--or a related virus. high titres of antibodies to measles virus were found in patients that correlated with the course of the disease. immunofluorescence tests revealed measles virus or a related antigen in lupus-affected tissues. inclusion bodies consisting of paramyxovirus-like ribonucleoprotein structures were regularly detected in both affected tissues and leukocytes. molecular ... | 1975 | 1091237 |
| recent observations on central nervous system lupus erythematosus. | the recent literature on cns-sle has been reviewed. an improved prognosis is noted that is thought to be due to the use of high-dose corticosteroids. the frequencies of the various neurologic and psychiatric findings are discussed, and a distinction is noted between organic psychoses and functional psychiatric complaints. the question of corticosteroids versus cerebral vasculitis as the cause of the neuropsychiatric symptomatology in sle is examined, and the necessity of clear psychiatric diagno ... | 1975 | 1091976 |
| subacute sclerosing panencephalitis: destruction of human brain cells by antibody and complement in an autologous system. | 1975 | 1092498 | |
| immunologic injury of cultured cells infected with measles virus. i. role of ifg antibody and the alternative complement pathway. | in these studies, a number of human cell lines including epithelial, neural, glial, and lymphoid cells infected with several strains of measles virus were found to be lysed upon incubation with fresh sera from humans containing antibody measles virus. in all instances, the cytolytic event was mediated by alternative complement (c) pathway without a significant contribution from classical pathway. in contrast, isolated measles virus in conjunction with antibody was found to selectively activate t ... | 1975 | 1092789 |
| immunization of children with attenuated measles-rubella bivalent vaccine. | the effects of simultaneous administration of schwarz-strain measles virus vaccine and cendehill-strain rubella virus vaccine as a single bivalent injection was evaluated in 346 children susceptible to both diseases. with placebo and monovalent controls, four bivalent preparations were used in a double-blind protocol to determine the effects of variations in the concentration of one or both components. no unusual reactions occurred and simultaneous administration did not enhance clinical reactiv ... | 1975 | 1093389 |
| [antibodies against measles virus and antigens of the central nervous system in sera of patients with multiple sclerosis]. | 1975 | 1095847 | |
| subacute sclerosing panencephalitis. | 1975 | 1096780 | |
| subacute sclerosing panencephalitis (sspe). | subacute sclerosing panencephalitis (sspe) is a degenerative disease of the central nervous system occurring in children and adolescents. the measles virus, or a virus closely associated, plays an important role in the disease. sspe appears years after these children have had the measles but still a measles-like virus can be found in their brain and in other organs. a certain deficit, still to be defined of the cell-mediated immunity as a chronic stimulation of the antibody response against the ... | 1975 | 1096980 |
| a study of immunoglobulin m antibody to measles, canine distemper, and rinderpest viruses in sera of patients with subacute sclerosing panencephalitis. | seven boys were studied who had the clinical features of subacute sclerosing panencephalitis (sspe) and whose brain histology was consistent with sspe. measles antigen was detected in the seven brains by the direct fluorescent antibody method. three out of the seven boys had in their sera measles specific immunoglobulin m (igm) which was detected by the indirect fluorescent antibody method, and the cell receptors for it were acetone stable. a prozone effect was noted in the sera of two patients. ... | 1975 | 1097472 |
| the production of a temperature-sensitive persistent measles virus infection. | a persistent infection of measles virus was established in hep2 cells. all cells contained virus antigen when tested by specific immunofluorescence and approx. 50% were positive by haemadsorption. infectious virus released into the supernatant medium was usually equivalent to no more than 0-001 p.f.u./cell, but between 10 and 40% of the infected cells produced plaques when plated on vero cells. passage of persistently infected cultures in the presence of measles antibody had no effect on the pro ... | 1975 | 1099170 |
| comparative studies on subacute sclerosing panencephalitis virus and a usual measles virus with special reference to their capacities to produce viral hemagglutinin in vero cells. | various comparative studies were made on the capacities of a cell-associated subacute sclerosing panencephalitis agent (sspe agent, niigata/1 strain) and a usual measles virus (toyoshima strain) to produce measles virus hemagglutinin (mv-hanim) in vero cells. the results obtained by various methods, such as the hemagglutination test (ha), hemadsorption test (had), antibody blocking test, antibody inducing test and fluorescent antibody technique (fat) using monospecific antibody to mv-hanin, cons ... | 1975 | 1101885 |
| age dependence of viral expression. electron microscopic and immunoperoxidase studies of measles virus replication in mice. | the hamster neurotropic strain of measles virus inoculated intracerebrally into balb/c mice causes a uniformly fatal encephalitis with production of infectious virus in 1- to 2-day-old suckling mice but a 31 per cent mortality with production of measles virus antigen without production of infectious virus in 4-week-weanling mice (8). these two groups of animals were studied using routine electron microscopy and the immunoperoxidase technique in order to determine the nature of the measles virus ... | 1975 | 1102777 |
| an immunofluorescent and electron microscopic study of measles skin eruptions. | immunofluorescent study was attempted to determine whether or not virus antigen were present in the epidermis of measles eruptions. the electron microscopic observations of the same materials were also performed to detect viral localization in affected skins. the failure to detect any virus antigen in affected eipdermis throughout all eruptive stages seems to be sufficient evidence to conclude that measles rash is not a manifestation of viral replication in the epidermis. dotted fluorescences we ... | 1975 | 1105894 |
| the isolation and characterization of a strain of subacute sclerosing panencephalitis measles-related virus. | the isolation of a measles-like virus in cv-1 cell cultures from a biopsy specimen obtained from a case of subacute sclerosing panencephalitis (sspe) is reported. evidence of the presence of cell-free virus was obtained from the fifth cell culture passage of the isolated virus. the virus was identified as measles-related by standard immune sera. if study did not show relevant differences between the isolated virus and the edmonston strain of measles virus, even though the proportion of cells sho ... | 1975 | 1106294 |
| acute and chronic infection of human lymphoblastoid cell lines with measles virus. | several human continuous lymphoblastoid cell lines (lcl) having t or b characteristics were infected with low and high passage strains of measles virus. all of the cell lines were susceptible to one or the other or to both strains of measles virus with the production of typical syncytial giant cells and released cell-free infectious virus into the supernatant medium. there was no consistent pattern of susceptibility of lcl with either t or b characteristics to infection by measles virus. viral i ... | 1976 | 1107427 |
| [possible mechanisms of chronic viral infections (author's transl)]. | 1975 | 1108450 | |
| measles virus: an unwanted variant causing hydrocephalus. | mutagenization of measles virus with proflavine produced a temperature-sensitive mutant capable of inducing hydrocephalus following intracranial inoculation of newborn hamsters. hydrocephalus was not produced by the parental strain or by other measles virus mutants. thus, mutants can be the causative agents of disease not associated with the parental strain. the results dictate caution in the use and distribution of experimentally induced virus variants. | 1975 | 1111114 |
| measles virus antibodies in serum and cerebrospinal fluid in patients with multiple sclerosis and other neurological disorders, with special reference to measles antibody synthesis within the central nervous system. | measles virus hemagglutination-inhibiting (hi) and gel precipitating (gp) antibodies were determined in sera and cerebrospinal fluids (csf) from 65 patinets with multiple sclerosis (ms) and 65 patients with other neurological diseases. the serological results were correlated to content of immunoglobulin-g (igg) and electrophoretic patterns of sera and csf. measles gp antibodies, identified as directed against measles virus ribonucleoprotein antigens, were detected in sera and in csf from a signi ... | 1975 | 1113135 |
| humoral immune response in children with measles. | twenty-eight black children with complicated measles were investigated for their capacity to produce antibodies when stimulated with tab antigen. their measles antibody titres were also measured. antibody production to tab was defective, especially the "h" antibody. production of measles antibody was sometimes delayed in its appearance but subsequently reached normal levels. | 1975 | 1114409 |
| experimental viral labyrinthitis. | 1975 | 1118012 | |
| virus antibodies in serum and synovial fluid of patients with rheumatoid arthritis and other connective tissue diseases. | rubella and influenza a (h3n2) haemagglutination inhibition (hi) antibody titres and measles complement-fixing (cf), haemagglutination inhibition (hi), haemolysis inhibition (hli), and ribonucleoprotein gel precipitation (rnp-gp) antibody titres were studied in the serum and synovial fluid of twenty patients with rheumatoid arthritis (ra), two patients with ankylosing spondylitis, and two patients with reiter's syndrome. antibody titres were also studied in the serum and csf of four patients wit ... | 1975 | 1124954 |
| additional evidence that the cell-associated immune system is the primary host defense against measles (rubeola). | 1975 | 1125984 | |
| persistence of measles antibody after immunization. | 1975 | 1126966 | |
| serological evaluation of measles virus (schwarz strain), mumps virus (jeryl lynn strain) and rubella virus (cendehill strain) combination vaccines. | 1975 | 1126967 | |
| [clinical and serological observations on 10 cases of neuraxitis caused by measles]. | 1975 | 1128471 | |
| experiences in mass prevention of measles by vaccination. | 1975 | 1145714 | |
| evaluation of methods designed to reduce cost of measles vaccine programmes. | 1975 | 1145715 | |
| measles vaccine in dogs: efficacy against aerosol challenge with virulent canine distemper virus. | fifty young beagle pups were used in studies on the efficacy of measles virus vaccine in providing protection against virulent canine distemper (cd) virus given intranasally. among 29 dogs vaccinated with measles virus vaccine and subsequently exposed to virulent cd virus, 1 died, 7 developed relatively severe signs of cd, 15 had mild signs of distemper, and 6 remained clinically normal. of 15 unvaccinated dogs similarly exposed to virulent cd virus, 11 succumbed to distemper. six pups vaccinate ... | 1975 | 1150494 |
| microassay of measles and mumps virus and antibody in vero cells. | 1975 | 1158903 | |
| differences in the appearance of antibodies to structural components of measles virus after immunization with inactivated and live virus. | children immunized with inactivated (tween 80 and diethyl ether, te) measles vaccine, attenuated live vaccine, or a combination of the two types were studied with regard to the production of hemagglutination-inhibiting (hai), hemolysis-inhibiting (hli), and nucleocapsid complement-fixing (cf) antibodies. for identification of antibodies to envelope components distinct from hemagglutinin. hli tests were done both before and after removal of hai antibodies with te-treated virus antigen. immunizati ... | 1975 | 1159329 |
| subacute sclerosing panencephalitis in the hamster. ultrastructure of the acute disease in newborns and weanlings. | acute subacute sclerosing panencephalitis has been investigated in both newborn and weanling hamsters intracerebrally inoculated with a human subacute sclerosing panencephalitis isolate (hbs) adapted to grow in hamster central nervous system (cns) tissue. newborn animals developed a disease which was fatal in approximately 1 week whereas most weanlings showed signs of an acute disease after day 8, from which a significant number recovered. ultrastructurally, the human subacute sclerosing panence ... | 1975 | 1160338 |
| [viral inclusions in subacute sclerosing panencephalitis]. | 1975 | 1164133 | |
| growth of measles virus in nervous tissues. iii. neurovirulence of sspe virus in ferrets. | the niigata-1 strain isolated from a patient with subacute sclerosing panencephalitis (sspe) was inoculated intracerebrally into ferrets. neurological signs developed in about 1 week in most of the animals. histopathological examinations of the central nervous tissues revealed degenerative lesions in the parenchyma of the brains and inflammatory reactions predominantly in the meninges and choroid plexus. virus antigen was demonstrated mainly in the nerve cells by immunofluorescent staining. the ... | 1975 | 1165608 |
| [subacute sclerosing panencephalitis: epidemiology of an atypical infection with a measles virus-like agent]. | 1975 | 1165949 | |
| report of a workshop: disease accentuation after immunization with inactivated microbial vaccines. | 1975 | 1169271 | |
| proceedings: lymphocyte-mediated cytotoxicity to viruses in patients with multiple sclerosis: presence of a blocking factor. | 1975 | 1169714 |