Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| viral antigens and antibodies in hepatitis b infection. | hepatitis b virus antigens and antibodies were detected in the sera of acute and persistently infected patients. evidence of active virus replication was confined to immediately before or during the initial detection of hepatitis b surface antigen during acute hepatitis b. hepatitis b core antibody appeared during the period of antigenaemia and preceded recovery. hepatitis b e antigen was dound in a proportion of sera which contained significant levels of virus particles. in contrast, all sera c ... | 1978 | 670424 |
| [hbsag negative chronic active hepatitis: presence of sanded nuclei in hepatocytes]. | 1978 | 673742 | |
| [hepatitis b virus infection in tuberculous patients]. | 1978 | 673866 | |
| [hepatitis virus. identification and immuno-pathogenic mechanisms]. | 1978 | 675105 | |
| [prospects for vaccination against hepatitis b]. | 1978 | 675110 | |
| infection of the common bedbug (cimex lectularius l) with hepatitis b virus in south africa. | a total of 1 368 bedbugs of the species cimex lectularius l were collected mainly from huts in villages or on farms at 6 localities in the northern transvaal. they were tested in pools of 10 for the presence of hepatitis b surface antigen (hbsag). none of 20 pools from pietersburg was hbsag-positive, but 32 out of 120 pools from the 5 other localities were hbsag-positive. estimated infection rates per 1 000 bugs were 17,1 (messina), 24,9 (waterpoort), 28,4 (letaba), 54,5 (potgietersrus) and 67,0 ... | 1978 | 675426 |
| different fates of hepatitis b virus markers during plasma fractionation: a clue to the infectivity of blood derivatives. | hepatitis b surface antigen (hbs ag) and associated particles, e antigen (e ag) and dna polymerase are unevenly distributed during cohn's cold ethanol fractionation of plasmas positive for these markers of the hepatitis b virus (hbv). most of the e ag, dane particles and dna polymerase are retained in fraction iii whereas the bulk of hbs ag is recovered in fraction iv where only 22 nm spheres and short filaments are still identified. these results suggest that differences in quantitative distrib ... | 1978 | 676242 |
| anti-hbc titers in hbeag and anti-hbe positive asymptomatic hbsag carriers. | a study was undertaken to establish markers for hbv replication in relation to hbeag and anti-hbe. hbsag carriers with serum hbeag had dna polymerase activity in the serum and hbcag in the liver nuclei. anti-hbe positive and anti-hbe/hbeag negative sera lacked these markers. for anti-hbc the following geometrical mean titers were calculated: 1: 12,000 for hbeag positive, 1:9, 100 for anti-hbe and anti-hbc positive, and 1:2,800 for anti-hbc positive anti-hbe/hbeag negative asymptomatic hbsag carr ... | 1978 | 676425 |
| familial clustering and immune response in family contacts of patients with hbsag-positive liver cirrhosis. | families of 11 patients with hepatitis b surface antigen (hbsag)-positive cirrhosis were studied to evaluate the immunologic correlates and extent of intrafamilial hbsag clustering. of 76 family contacts, 12 were identified to be asymptomatic carriers of hbsag and two were diagnosed to have hssag-positive cirrhosis. the over-all hbsag prevalence for the 76 contacts was 18% and that for all 87 members studied 29.0%. serologic evidence of hepatitis b virus (hbv) infection (either hbsag, anti-hbs, ... | 1978 | 677091 |
| [recent acquisitions on vertical transmission of viral hepatitis b]. | 1978 | 677679 | |
| long-term follow-up of chronic active hepatitis of moderate severity. | a group of patients with only moderately active chronic hepatitis has been studied. the follow-up was long (mean 87 months). all patients except one were treated with prednisone and/or azathioprine. of the hepatitis b virus positive patients two-thirds developed cirrhosis between the second and fifth year of evolution, while in the hepatitis b negative group this occurred in less than one-third. the transition to cirrhosis was clinically silent. the patients were all allowed to do their normal w ... | 1978 | 680585 |
| clinical and pathological study of asymptomatic hbsag carriers in chile. | a clinical, biochemical, and pathological study was performed in 38 chronic hbsag carriers. the study group is a part of 393 carriers found among 117 705 voluntary blood donors at the national blood bank, hospital del salvador, santiago, chile. none of the 38 carriers had a past history of illicit drug abuse, hepatitis, or work involving a high risk of hepatitis b virus infection. ten individuals had a normal liver biopsy, 17 reactive non-specific hepatitis, one fatty changes, four chr onic pers ... | 1978 | 680591 |
| hepatitis b core particles with endogenous dna polymerase activity from chimpanzee liver. | hepatitis b core antigen (hbcag) particles, approximately 27-28 nm in diameter and rho = 1.30-1.35 g/cm3, were purified from the liver of a chimpanzee experimentally infected with hepatitis b virus (hbv) while under cyclophosphamide treatment. the purified hbcag particles incorporated radioactive deoxythymidine triphosphate. the product was precipitable by trichloroacetic acid and sensitive to dnase, but resistant to digestion by rnase. the reaction required four deoxyribonucleosise triphosphate ... | 1978 | 681146 |
| infantile papular acrodermatitis (gianotti's disease) and intrafamilial occurence of acute hepatitis b with jaundice: age dependency of clinical manifestations of hepatitis b virus infection. | infantile papular acrodermatitis (ipa, gianotti's disease) is a clinical manifestation of hepatitis b virus (hbv) infection in childhood. an epidemic of of ipa occurred in matsuyama, japan, where 153 patients in a pediatric clinic had ipa between october 1974 and march 1977. in this period 12 mothers and two fathers of patients contracted acute hepatitis b with overt jaundice three to 14 months after their offspring had ipa. analysis of the subtype of hepatitis b surface antigen (hbsag) in the i ... | 1978 | 681797 |
| incomplete inactivation of hepatitis b virus after heat treatment at 60 c for 10 hours. | a 10(-3) dilution of pooled serum (positive for hepatitis b e antigen and dna polymerase activity) containing hepatitis b virus (hbv) in a titer 10(5) times the chimpanzee-infectious dose, was heated under water maintained at 60 c for 10 hr. there was a twofold decrease in the titer of hepatitis b surface antigen (hbsag) as measured by reverse passive hemagglutination after the heat treatment. the heated, diluted serum was still infectious and caused hbv infections in both seronegative chimpanze ... | 1978 | 681799 |
| differential activation of hepatitis b dna polymerase by detergent and salt. | three patterns of activity were evident when the differential activation of the dna polymerase associated with serum dane particles by nonionic detergent and salt was investigated. the patterns were obtained by plotting the increase in enzyme activity mediated by the detergent nonidet p-40 (np-40) in increasing concentrations of kcl compared to the activity observed in the absence of detergent. the pattern of differential activity of hepatitis b (hb) dna polymerase in detergent and salt was alte ... | 1978 | 681913 |
| [viruses--causes of human tumor forms]. | 1978 | 683122 | |
| [the quarantined dialysis room for australia-antigen-positive patients. theoretical, normative, structural, operational, organizational and management aspects]. | the technical features of dialysis facilitate the transmission of hepatitis b virus and the outbreak of possibly serious epidemics among patients and hospital staffs. statistical, epidemiological and clinical data have been collected on many occasions. they serve to emphasise the problem and the need for quarantined centres. the establishment of such a centre for hbsag-positive patients is discussed in the light of personal experience in the design and setting up of quarantined rooms. the underl ... | 1978 | 683587 |
| e antigen in hepatitis b virus infected dialysis patients: assessment of its prognostic value. | many investigations consider the presence of e antigen (hbeag) valuable in predicting which patients with acute hepatitis b are at risk of remaining infected and developing chronic liver disease. we tested this hypothesis in a retrospective study of serial samples from patients undergoing long-term hemodialysis. we found hbeag in the early phase of all hepatitis b virus (hbv) infections. there was no significant difference between transiently and persistently hepatitis b surface antigen (hbsag)- ... | 1978 | 686540 |
| [gianotti's disease--clinical variability in hepatitis b virus infection]. | 1978 | 691679 | |
| [hepatitis b virus infection as a risk factor for newborn infants]. | 1978 | 693125 | |
| [viral hepatitis]. | viral hepatitis is one of the most frequent infectious diseases of our time. it is of great concern to the epidemiological risk groups such as research laboratories, dialysis units and other public health agencies. the result of epidemiological, immunological, morphological and biochemical studies have demonstrated, that this disease is caused by at least two different viruses. the hepatitis a virus (hav) induces the type a hepatitis and the hepatitis b virus (hbv) the type b hepatitis. two anti ... | 1978 | 697524 |
| hbsag-positive chronic liver disease: inhibition of dna polymerase activity by vidarabine. | four patients who had chronic liver disease and were positive for hepatitis b surface antigen (hbsag) were treated with vidarabine, a synthetic purine nucleoside that inhibits dna polymerase activity in vitro and in vivo. before treatment all had raised serum dna polymerase concentrations. three also had hepatitis b e (hbe) and were shown by electron microscopy to have hepatitis b virus (dane) particles in their serum. in all patients 10 days' treatment with vidarabine resulted in an immediate l ... | 1978 | 698557 |
| syringe-transmitted hepatitis. | 1978 | 698666 | |
| full and empty dane particles in chronic hepatitis b virus infection: relation to hepatitis b e antigen and presence of liver damage. | circulating complete and defective hepatitis b virus forms, as represented by full, dna polymerase-positive and empty, dna polymerase-negative dane particles, respectively, were investigated in sera from patients with chronic hepatitis b virus infection and related to the presence of e antigen and antibody and to the histological findings on liver biopsy. complete hepatitis b virus particles were detected in the serum of all patients postive for e antigen, their percentage ranging from 15 to 61% ... | 1978 | 700329 |
| dental care and spread of hepatitis b virus infection. | sera from 576 healthy adults were tested for the hepatitis b surface antigen (hbsag) and antibody (anti-hbs) to evaluate the role of routine dental care as a factor in the spread of hepatitis b virus (hbv) infection. serological evidence of prior hbv infection, manifested by acquisition of anti-hbs, was detected in 97 (16.8%) individuals, and 6 (1.0%) were identified to be asymptomatic hbsag carriers. the anticipated correlations of hbsag and anti-hbs with age, country of birth, and socioeconomi ... | 1978 | 701467 |
| small vessel vasculitis caused by hepatitis b virus immune complexes. small vessel vasculitis and hbsag. | in a comprehensive study of 80 patients with vasculitis, 4 had concurrent hepatitis b virus (hbv) infection. polyarteritis nodosa was present in 2 and in the other 2, cutaneous vasculitis, presenting clinically as palpable or henoch-schönlein purpura. in one of these patients skin biopsies demonstrated granular deposits of igm, c3, c4, and the hepatitis b surface antigen (hbsag) and electron-dense deposits of aggregated 20-nm particles resembling hbsag in postcapillary venules. evidence for circ ... | 1978 | 701656 |
| serological diagnosis of acute hepatitis b infection. | the value of different serological assays of hepatitis b virus associated antigens and antibodies was tested in forty-eight consecutive cases of acute hepatitis negative for hbsag by agargel diffusion. the tests included radioimmunoassay of hbsag, igm and igg anti-hbs and counter-immunoelectrophoresis for anti-hbc detection. twelve cases were identified as hepatitis b (25%). eleven cases were positive for hbsag by ria, and only one case was detected by an increasing titre of antibodies alone. fu ... | 1978 | 705233 |
| occurrence of cirrhosis and primary liver cancer in an eskimo population hyperendemically infected with hepatitis b virus. | hepatitis type b is hyperendemic in greenland with serologic evidence of infection in 54% of adults and a hepatitis b surface antigen (hbsag) carrier rate of 7--25%. the impact of this infection rate on the occurrence of cirrhosis and primary liver cancer (plc) was studied. mortality rates for cirrhosis were obtained from official mortality statistics, 1951--1975. plc was identified by a study of all biopsy and necropsy material taken in the study area during the same period. neither cirrhosis n ... | 1978 | 707473 |
| aplastic anemia associated with type b viral hepatitis. | aplastic anemia is a recognized complication of viral hepatitis, but, to our knowledge, no cases associated with type b hepatitis have been described. we report the case of a patient who developed severe aplastic anemia very early in the course of infection with hepatitis b virus. | 1978 | 708179 |
| carcinoembryonic antigen: transmission by blood products. | 1978 | 709526 | |
| reversibility of hepatitis b virus-induced glomerulonephritis and chronic active hepatitis after spontaneous clearance of serum hepatitis b surface antigen. | a patient presenting with nephrotic syndrome was found to have hepatitis b surface antigen-positive chronic active hepatitis and membranoproliferative glomerulonephritis. glomeruli stained positive for hepatitis b surface antigen, igg, and c1q. after spontaneous clearance of hepatitis b surface antigen both the glomerulonephritis and the chronic active hepatitis improved. the natural history, pathogenesis, and treatment of this disease complex are discussed. | 1978 | 710868 |
| hepatitis b virus infection: more than meets the eye. | 1978 | 710869 | |
| routine use of counter-immunoelectrophoresis test for detecting antibody to hepatitis b virus core antigen. | tests by counter-immunoelectrophoresis for antibody to hepatitis b core antigen (anti-hbc) were introduced into a routine testing programme for evidence of hepatitis b virus infection. samples tested for anti-hbc were selected on the basis of the results of tests for hbsag and clinical details. the sensitivity and specificity of the test were assessed and correlations made with the presence of hbsag. the presence of anti-hbc was very useful in the interpretation of a doubtful positive result for ... | 1978 | 711911 |
| cell-mediated immune response to liver tissue antigen and hepatitis b surface antigen after infection with hepatitis b virus in humans. | the in vitro correlates of cell-mediated immunity to liver tissue antigens and hepatitis b surface antigen (hbsag) were studied in groups of subjects with acute and chronic hepatitis b virus (hbv) infection and in a population of hbv-seronegative controls. the technique of in vitro lymphocyte transformation (ltf) was employed in these studies. no ltf response to liver-specific antigen and hbsag was observed in the control population. ltf activity in response to hbsag was present in 11 of the 14 ... | 1978 | 712116 |
| mechanisms of maternal-fetal transmission of hepatitis b virus. | in a prospective study of maternal-fetal transmission of hepatitis b virus in 125 healthy mothers who were carriers of hepatitis b surface antigen (hbsag), preliminary results showed that the most important determinant in such transmission was the presence of hepatitis b e antigen in the mother. hbsag was detectable by solid-phase radioimmunoassay in 33% of amniotic fluid samples, 50% of cord blood samples, 71% of breast milk samples, and 95.3% of samples of gastric contents from newborns. the p ... | 1978 | 712120 |
| studies on hepatitis b surface antigen and antibody in nauru. i. distribution amongst nauruans. | the age specific prevalence of hepatitis b surface antigen and antibody was studied among a random sample of nauruans over the age of 10 years. overall, 79% of subjects showed evidence of past infection with hepatitis b virus with the highest prevalence among young people. while there was no difference in the infection rate between males and females, the carrier rate in males was 50% higher. in both sexes the carrier rate declined with increasing age. significant differences in carrier rates wer ... | 1978 | 717627 |
| large scale purification of hepatitis b surface antigen (hbsag). | in october 1975, a specific immunization by means of a formalin inactivated hepatitis b vaccine has been introduced to protect patients and staff members of three haemodialysis units of the loire valley (tours, blois, orléans). after two years follow-up the innocuity and efficacy of this preparation have been shown to be very satisfactory in the conditions under which it was used. a method of vaccine preparation has been instituted in the development of industrial batches of vaccine to be used f ... | 1978 | 718020 |
| a study of street heroin lots for the presence of the hepatitis b surface antigen. | hepatitis b surface antigen (hbsag) of subtype ay predominates among narcotic addicts infected with hepatitis b virus (hbv) in europe, australia and the united states. however, the ad subtype predominates among the non-addict carriers of hbsag. we investigated the possibility that heroin lots were contaminated with hbv at a source of opium production, the middle east, a geographical region where hbsag/ay predominates in the general population. one hundred and nine lots of street heroin were assa ... | 1978 | 720209 |
| high risk groups for hepatitis b virus infection in a university hospital staff as determined by detection of hb antigens, antibodies, and dane particles. | the prevalence of hbsag and anti-hbs has been determined by solid-phase radioimmunoassay in 1815 university hospital employees and compared with the results obtained by investigating 131 metal workers and 86 laboratory technicians. hospital personnel and here especially dialysis staff members and laboratory workers is at higher risk to acquire a hepatitis b virus infection than population compartments without contact to patients or blood. electronmicroscopic studies revealed that a considerable ... | 1978 | 723787 |
| hepatitis-b virus markers in patients with bleeding disorders and in healthy blood donors. | 1978 | 726013 | |
| hepatitis b-virus markers and immune complexes in hbsag-positive patients on hemodialysis. | 1978 | 726810 | |
| studies on hepatitis b surface antigen and antibody in nauru. ii. distribution amongst gilbert and ellice (tuvalu) islanders. | the age-specific prevalence of hepatitis b surface antigen (hbsag) and antibody was studied in a random sample of gilbert and ellice islanders over the age of 10 years living in nauru. while approximately 82% of each group showed evidence of past infection with hepatitis b virus (hbv) the carriage rate of hbsag was significantly lower in the polynesian ellice islanders (7.5%) than in the micronesian gilbertese (26.3%) and indigenous nauruans (14.7%). these findings suggest that micronesian and p ... | 1978 | 727326 |
| [role of chronic hbsag carriers in intrafamilial diffusion of hepatitis b virus infection]. | to assess the hepatitis b virus infection risk to household contacts exposed to hbsag-positive chronic carriers, 169 family members of 20 healthy carriers of hbsag and of 12 with chronic hepatitis were followed up prospectively for two to five years. all family members are investigated for the presence of serum hbsag/antihbs system and for the presence of liver disease. our results indicate that the family contacts of hbsag carriers with evidence of chronic liver disease are at greater risk of e ... | 1978 | 728268 |
| the epidemiology of hepatitis b infection in housestaff. | ninety-nine medical and surgical house officers were prospectively evaluated during internship and residency for the development of hepatitis b virus (hbv) infection. the overall incidence of hepatitis b was 10.2% per year. eighty-six percent of episodes were subclinical. the greatest risk factor appeared to be frequent hand-to-mouth activity such as smoking or licking requisition labels. the presence of a hemodialysis or transplantation unit may be an additional institutional risk factor. hbv i ... | 1978 | 730389 |
| e-antigen: a link between immune response and infectivity in hepatitis b? | in a study of the distribution of e-antigen and anti-e in subjects whose blood was positive for hepatitis b surface antigen (hbsag), patients with acute hepatitis b who were tested during the incubation period were all e-antigen-positive but after the onset of illness e-antigen was detected in only 11%. persistence, and in some instances reappearance of e-antigen in those who became long-term carriers of hbsag was associated with high titres of hbsag. there was a high incidence of e-antigen in t ... | 1978 | 731022 |
| effect of ethanol during hepatitis b virus infection in chimpanzees. | to determine whether the use of ethyl alcohol (ethanol, c2h5oh) may increase the liver damage caused by hepatitis b virus infection, ethanol was infused into four chimpanzees on one or two occasions during the course of natural or experimentally induced hepatitis b virus infections. a fifth chimpanzee, without active hepatitis b virus infection, served as a control. moderate elevations of serum aspartate or alanine aminotransferases occurred in four of the five chimpanzees, including the control ... | 1978 | 731211 |
| diagnosis of hepatitis b by dane particle associated dna polymerase assay. | we have studied prospectively 478 subjects exposed to hepatitis b virus and 20 pregnant women who developed hbs antigen during the last trimester of pregnancy. the results suggest that the dna polymerase assay might be useful for the diagnosis of hepatitis b infection and that in confirmed cases of hepatitis, the enzyme might be detected in the absence of hbs antigen. hbe antigen appeared in 19% of those subjects who developed hbs and a positive correlation between hbe antigen and dna polymerase ... | 1978 | 731223 |
| the detection of dna polymerase activity in the diagnosis of hbv infection. | 1978 | 731224 | |
| the role of the hepatitis b virus infection in patients with chronic hepatitis in argentina. | over a seven-year period, we monitored 221 patients with chronic hepatitis from two medical centers. by using the counterlectrophoresis (cep) test to detect the presence of hbsag and anti-hbc, or both, we established that 87.7% of them had hepatitis b infection. serum specimens originally found negative for hbsag by cep were further tested by reversed passive hemagglutination (rph), and those originally found negative for anti-hbc by cep were further tested by radioimmunoassay (ria). five patien ... | 1978 | 731225 |
| the igm antibody responses to the core antigen of hepatitis b virus. | little is known about the immunoglobulin class of antibodies to hbcag. in the present study sera containing anti-hbc were fractionated by surcose density-gradient centrifugation, and all serum fractions were tested against hbcag by immunoelectro-osmophoresis. in addition selected fractions were examined by complement fixation test, immune adherence hemagglutination and immune electron microscopy. anti-hbc activity in igg serum fractions was demonstrated by all four techniques used, but hbcag-spe ... | 1978 | 731226 |
| [intrahospital transmission of hepatitis b virus]. | 1978 | 734508 | |
| containment of hepatitis b virus infection in a hemodialysis unit. | the unsuspected introduction of a carrier of hepatitis b virus into a hepatitis-free hemodialysis unit coincided with a routine serologic survey in early april 1976. thus the prevalence of hepatitis b surface antigen and its antibody was known for the 42 patients and 23 personnel at risk. control consisted of isolating the patient identified as a carrier seven days after admission. immune globulin was not given to potentially exposed persons. during a 15-month period, only one case of icteric he ... | 1978 | 739161 |
| prevalence of antibody to hepatitis b virus in melbourne. | 1978 | 739922 | |
| the liver as a barrier against antigens in viral hepatitis infection. | 1978 | 740042 | |
| [the importance of serum inhibitory factors (sif) in the course and for the prognosis of chronic hbv-induced liver diseases. results of a 3 year course study]. | 1978 | 741879 | |
| [subpopulations and subtypes of dane particles]. | 1978 | 741880 | |
| [hepatitis b virus markers and immune complexes in hepatitis b antigen positive dialysis patients]. | 1978 | 741882 | |
| [anti-hbc titer in hbeag(e-antigen) and anti-hbe(anti-e) positive asymptomatic hepatitis b surface antigen (hbsag) carriers]. | 1978 | 742155 | |
| hepatitis and hepatitis b surface antigen and antibody in dentists. | dentists were surveyed regarding a history of hepatitis and the presence in the blood of hepatitis b surface antigen (hbsag) and antibody (anti-hbs) to determine whether they were at high risk of exposure to hepatitis b virus. of 288 canadian dentists 5.2% gave a history of hepatitis after graduation. this proportion is similar to that for 1462 ontario dentists (6.3%) and that for 3162 accountants (5.1%) who had previously completed a mailed questionnaire. one dentist (0.3%) was hbsag-positive a ... | 1978 | 743666 |
| viral hepatitis: lack of transmission in an athenian school. | in the 1975-76 school year, 3 cases of icteric hepatitis occurred almost simultaneously in 2 grades of an athenian school. an initial survey of the 2 classes approximately one week later found that 88 of 94 children were susceptible to type a hepatitis. no further clinical cases occurred. a second survey at the end of the school year revealed only 2 subclinical hepatitis a virus infections: one coincident with the overt cases in november, and a second from extramural exposure in february. two ca ... | 1978 | 744672 |
| acute hepatitis: significance of antibody to hepatitis b core antigen. | the value of testing for core antibody (anti hbc) in acute hepatitis was assessed in 503 patients. all hepatitis b surface antigen (hbsag) positive patients tested were also anti hbc positive. of the 110 hbsag negative, anti hbc positive patients, 32 were found to have surface antibody, indicating previous infection with hepatitis b virus (hbv). of the remaining 78 patients in whom anti hbc alone was detectable, follow-up specimens were received from 28 and, of these, 21 were then found to be an ... | 1978 | 748385 |
| remarks on the pathogenic significance of hbsag subtypes. | the frequent controversies concerning the possible different pathogenic significance of antigenic hepatitis b virus subtypes determined the authors to analyse the mean values of some biochemical tests in two groups of acute viral hepatitis patients. the results obtained show that a more marked alteration of these values is correlated with the presence of hbsag/ay in one of the groups (89 patients) and with that of hbsag/ad in the other group (33 patients). some explanations of these findings are ... | 1978 | 749332 |
| spontaneous resolution of severe aplastic anemia associated with viral hepatitis a in a 6-year-old child. | recovery from acquired aplastic anemia associated with hepatitis is rare. this case of a 6-year-old boy with severe aplastic anemia is the first reported association of this disease with a hepatitis a infection. antibody to hepatitis a (anti-ha) was not detected on admission, but was detected three weeks later. infection with hepatitis b virus, cytomegalovirus (cmv), and epstein-barr virus (ebv) were excluded. the peak titer of anti-ha was higher than would be expected for passive transfer of an ... | 1978 | 752262 |
| [infection with hepatitis b virus in lepers. ii. serum titers of surface antigens of hepatitis b virus and of homologous antibodies]. | 1978 | 755524 | |
| [infection with hepatitis b virus in lepers. relation between the envelope markers of the hepatitis b virus and transaminasemia]. | 1978 | 755525 | |
| [viral hepatitis type b. preventive measures]. | 1978 | 756977 | |
| hepatitis b virus infection on taiwan. | 1977 | 757978 | |
| viral hepatitis, type b. studies on natural history and prevention re-examined. | frozen serial serum specimens obtained from past studies on the natural history and prevention of type b hepatitis in children were retested by radioimmunoassay for the following markers of hepatitis b infection: hepatitis b surface antigen (hbsag) and antibody (anti-hbs), hepatitis b e antigen (hbeag) and antibody (anti-hbe), and antibody to hepatitis b core antigen (anti-hbc). the interval between exposure and evidence of viremia (hbsag) was as short as six days. hbsag and hbeag persisted for ... | 1979 | 758598 |
| hepatitis b virus. inappropriate reactions to transmission risks. | ten patients designated as hepatitis b surface antigen (hbsag) carriers were screened for inappropriate reactions to their disease. assessment with a 32-item questionnaire showed three carriers to have underreacted to the risks of hbsag transmission through misunderstandings or denial concerning the disease. one carrier, through severe social withdrawal, showed overreaction to the possibilities of disease transmission. counseling was provided regarding the risks of hbsag transmission. at a one-m ... | 1979 | 762815 |
| transmission of hepatitis type b from healthy hbsag-positive mothers. | seventeen mothers, all apparently healthy carriers of hepatitis-b surface antigen (hbsag) during pregnancy, and their children were studied for four to five years to determine the transmission rate of hepatitis-b virus infection. all the mothers had antibody against hepatitis-b core antigen in addition to hbsag. one of them, a renal transplant recipient, was persistently positive for hepatitis-b-associated e antigen (hbeag), while the remaining 16, who were detected during screening of healthy p ... | 1976 | 764911 |
| evidence for the multiplication of hepatitis b virus in "oval cell" culture originated from human embryonic liver. | growth conditions fof human oval cells (immature hepatocytes),evidence of hepatitis b (hb) antigen synthesis in oval cells as revealed by immunofluorescent staining and successful passage of such an agent in the culture fluid up to the 4th passage are described. the results have been proved to be readily reproducible with different inocula. the oval cells used in these experiments were defined as small round cells, with scant cytoplasm, vesicular nuclei and small nucleoli, vitally stained with i ... | 1976 | 773401 |
| hepatitis b: nature of the virus and prospects for vaccine development. | 1976 | 775545 | |
| comparison of prothrombin complex concentrate and vitamin k1 in oral anticoagulant reversal. | a randomised clinical trial was undertaken to compare the value of a factor ii, ix, and x concentrate (prothromplex) with intravenous vitamin k1 (2-5 mg) in reversing an overdose of oral anticoagulants. rapid partial correction of the prothrombin time, partial thromboplastin time, and the clotting factor assays were observed with the concentrate, but these changes were not always sustained. in contrast vitamin k1 did not show any great effect at two hours but at 24 hours there was always over-co ... | 1976 | 776348 |
| precursor lesions for liver cancer in humans. | our knowledge of the cellular changes that lead to liver cell carcinoma in humans is limited by proper and necessary ethical restriction on clinical research. we know rather more about risk factors, the most important of which is cirrhosis, it seems that both the causative agent and the time of duration of the cirrhotic process are relevent to the magnitude of this risk. according to present knowledge, alpha1-antitrypsin deficiency, alcoholism, naturally occurring carcinogens, drugs, and the hep ... | 1976 | 776394 |
| sanded nuclei in hepatitis b: eosinophilic inclusions in liver cell nuclei due to excess in hepatitis b core antigen formation. | in confirmation of earlier descriptions by huang et al. (huang s-n, millman i, o'connell a, aronoff a, gault h, blumberg bs: am j pathol 67: 453, 1972) nuclear eosinophilic inclusions due to excess hbcag particles have been identified in cases of chronic hepatitis b virus infection. as the euchromatin space of affected nuclei is "sanded" by numerous core particles with concomitant dissolution of the chromatin network, spiky, finely granular, and eosinophilic inclusions without a limiting membran ... | 1976 | 781402 |
| [study of a direct antibody against nuclear antigen in hepatitis b using indirect immunofluorescence]. | 1975 | 782488 | |
| the liver and the antigens of hepatitis b. | a decade ago an antigen was identified by immunodiffusion and subsequently proved to be closely associated with hepatitis b virus. further studies showed that hepatitis b virus circulates as a large particle containing a protein coat and a dna core, and that excess coat particles are produced and circulate freely. immunization with surface protein produced protective antibodies, and this led to the development of a prototype vaccine. patients with hepatitis may develop a variety of extrahepatic ... | 1976 | 788584 |
| 1976 nobel prize winner in physiology or medicine: discoveries of new factors for etiology and distribution of infectious diseases]. | 1976 | 790054 | |
| the virus of hepatitis, type b. (second of two parts). | 1976 | 790185 | |
| hepatitis b surface antigen in saliva, impetiginous lesions, and the environment in two remote alaskan villages. | a study was conducted in an area of hepatitis b hyperendemicity to determin whether contact with infective bodily secretions or contaminated environmental surfaces could be involved in the transmission of the hepatitis b virus. hepatitis b surface antigen was detected in gingival swab, saliva, and impetiginous lesion exudate samples from children. hepatitis b surface antigen also was found in swab samples of surfaces frequently touched or placed in the mouth. in the absence of classical exposure ... | 1976 | 791124 |
| immunofluorescent localization of hepatitis b antigens in chimpanzee tissues. | three chimpanzee chronic carriers of hepatitis b surface antigen (hbs ag) were examined by immunofluorescent techniques to determine the localization of hbs ag and hepatitis b core antigen (hbc ag) in their tissues. all specimens were quick-frozen in liquid nitrogen and stored at -70degrees until sectioned. frozen sections were prepared and stained for examination by fluorescent microscopy. for staining, anti-hbs and anti-hbc labeled with fluorescein isothiocyanate were used. hbs ag was found in ... | 1975 | 791892 |
| [classification and infectiousness of chronic hepatitis b, defined by the dane particle in the blood and virus components in the liver]. | 55 hbag seropositive patients with chronic hepatitis b selected from a total of 217 liver biopsies were studied for the presence of hbcag and hbsag in the liver tissue and of dane particles in blood by immunofluorescence and electron microscopy. among 27 patients with non-aggressive chronic inflammation the following constellations were found: a) 19 patients (13 with nonspecific reactive hepatitis, 6 with chronic persistent hepatitis) had isolated hbsag expression in the tissue (hbs type) and of ... | 1976 | 792997 |
| hepatitis b infections in renal transplantied patients. | multiple serum samples collected from ten renal transplanted patients were examined by means of radioimmunoassay procedures in order to check and quantitate both hepatitis b surface antigen (hbs ag) and antibody to it (anti-hbs). the anticomplementary activity of serum, levels of serum immunoglobulins and other laboratory parameters were also tested and related to the clinical followup of patients in the pre- and post-operative period, during which they underwent immunosuppressive treatment with ... | 1976 | 798598 |
| the clinical problem of hepatitis transmission;. | although blood banks in this country have been testing every unit of blood for hepatitis b surface antigen (hbsag) by one of the highly sensitive "third generation" methods (radioimmunoassay or reversed passive hemagglutination) since september, 1975, post-transfusion hepatitis (pth) still remains the major hazard to patients who require transfusion with blood and blood products. since there may be an interval of many months between transfusion and onset of pth and many cases are subclinical, th ... | 1976 | 799307 |
| immunological aspects of hepatitis b virus infection. | infection of man and chimpanzees with the hepatitis b virus (hbv) is associated with diffuse hepatocellular infection and variable manifestations of disease which may not only reflect the character of the host immune response, but also depend upon differences in the cellular biology of this minimally cytopathic or noncytopathic agent. the presence of hepatocellular injury and the course of disease do not appear to be related to the presence of viral antigens in hepatocytes or to the specific pat ... | 1975 | 799469 |
| [presence of antigen associated with hepatitis b in saliva of patients with acute viral hepatitis, in "healthy carriers" and in mentally retarded children. part 2]. | 1976 | 801434 | |
| hepatitis b virus antigen quantitation by radioimmunoassay (ria) in viral hepatitis and in chronic liver diseases. | the incidence of hbag in viral hepatitis, in chronic active hepatitis and in cirrhosis has been investigated by using immunological methods and a solid-phase radioimmunoassay. ria demonstrated as positive: 90% of 20 patients with posttransfusion hepatitis; 88% of 50 patients with acute viral hepatitis; 100% of 13 patients with chronic active hepatitis and 35% of 20 patients with cirrhosis; whereas the frequency of hbag in the same patients appeared to be lower by agd, ciep and cf. the measure of ... | 1975 | 804225 |
| hepatitis b antigen and antibody in active chronic hepatitis and other liver diseases in australia. a multicenter collaborative study. | in a multicenter cooperative study, sera from 85 patients with active chronic hepatitis (ach) were examined for the presence of hepatitis b (australia) antigen (hbag) by radioimmunoassay (ria) and antibody to hbag (anti-hbag) by ria and passive hemagglutination (pha), the most sensitive currently available techniques. in addition, sera from 83 patients with other liver diseases 98 other hospital patients, and 67 healthy controls were tested. hbag was detected in 3 of the 85 patients (four percen ... | 1975 | 804811 |
| serologic characterization of patients with two episodes of acute viral hepatitis. | since testing for serologic markers of hepatitis b virus (hbv) became routine, we have observed in our hospital 28 patients with two distinct episodes of illnesses, each of which was compatible with acute viral hepatitis. we found no distinctions between the first and second bouts with respect to clinical characteristics, abnormalities of liver function or epidemiologic background. testing of specimens obtained during each of the two acute episodes, the interval between the two episodes and the ... | 1975 | 806228 |
| transmission of hepatitis b to the rhesus monkey. | the rhesus monkey does provide a suitable laboratory animal model for studying hepatitis b virus and for investigating various aspects of interaction between this infectious agent and the host. this species of non-human primate, however, offers a less sensitive animal model for hepatitis b infection than the chimpanzee. | 1975 | 812744 |
| [a correlation between histocompatibility antigens hl-a 1 and 8 and an improved defense in the chronic uremic patient against hepatitis b virus]. | histocompatibility antigens have been studied in 328 uraemic patients treated by chronic haemodialysis, of whom 201 were contaminated by hepatitis-b virus associated antigen (hbs ag). the frequency of the phenotypes hl-a 1 (36.2%), hl-a 8 (29.8%) and the hl-a 1,8 (23.4%) was significantly higher in the group of 47 patients who were able to eliminate hbs ag after a transient antigenemia, than in the group of 154 patients who became chronic carriers of this antigen (p less than 0.01 for hl-a 1,8 a ... | 1975 | 815019 |
| [attempts to culture hepatitis b virus on human fetal hepatocytes: preliminary results]. | foetal human hepatocytes have been maintained in prolonged culture and inoculated with two pools of hbs ag positive sera. these two pools differed from each other by the presence or the absence of dane particles. the cultures were examined during 8 weeks. hbs ag did not appear in the culture medium. however, it may be revealed inconstantly and fugaciously by ultasonic lysis of cells infected by sera containing dane particles. in the cell debris, 27 nm nucleocapsides of hbc specificity are observ ... | 1976 | 816528 |
| development and chimpanzee testing of a vaccine against human hepatitis b. | highly purified hepatitis b virus surface antigen (australia antigen) purified by physical and chemical procedures from infected human plasma was used to prepare hepatitis b vaccine. the purified antigen was treated with formalin and the vaccine was tested exhaustively for safety by ordinary procedures and additionally in marmosets (for live hepatitis b virus). the vaccine was highly potent, inducing antibody in guinea pigs, grivet monkeys, and chimpanzees given three doses of vaccine containing ... | 1976 | 817293 |
| association of dane particles with e antigen in the serum of asymptomatic carriers of hepatitis b surface antigen. | asymptomatic carriers of hepatitis b surface antigen (hbsag) were surveyed for serum e antigen (e ag) and antibody to e (anti-e) by immunodiffusion. seventeen serum samples containing e ag and 17 containing anti-e, but with similar hbsag titers, were tested for the presence of hepatitis b core antigen (hbcag) by means of immune adherence hemagglutination method. hbcag activity was detected in all of the samples containing e ag, and the titer of hbcag paralleled that of hbsag in each serum. in re ... | 1976 | 819577 |
| vaccine against human hepatitis b. | a highly purified and inactivated vaccine was made of hepatitis b virus surface antigen. the vaccine was tested exhaustively for safety by ordinary procedures and additionally in chimpanzees and marmosets. it was highly potent and induced antibody in guinea pigs, grivet monkeys, and chimpanzees after three doses of vaccine were given subcutaneously. chimpanzees given three doses of vaccine were protected against challenge with 1,000 chimpanzee-infectious doses of live human hepatitis b virus giv ... | 1976 | 819667 |
| viral hepatitis, type b. | 1976 | 822594 | |
| [familial transmission of hepatitis b virus]. | 1976 | 824389 | |
| hepatitis b subunit vaccine: a preliminary report of safety and efficacy tests in chimpanzees. | the 22 nm spherical form of hepatitis b surface antigen was purified from the serum or plasma of chronic carriers of the antigen. antigens of subtypes ayw and adr were individually prepared by isopycnic banding in cesium chloride followed by rate zonal separation in sucrose. each preparation was stabilized with human serum albumin, and aliquots were inactivated with 1:2000 formalin at 37 c for 96 hours. the potency and immunogenicity of each preparation were determined: both antigenicity and imm ... | 1975 | 828832 |
| [permeability of dialysis membranes for hepatitis-b virus: on the prophylaxis of hepatitis in a haemodialysis centre (author's transl)]. | dialysis fluids of two hepatitis-bs (hbs) antigen-positive dialysis patients were tested for hepatitis-b virus. total dialysate volume of 5.5 litres each - as obtained on haemodialysis with the redy-recirculation system - was concentrated by ultrafiltration and trap and rate-zonal ultracentrifugation, followed by fractionation, and purified. electron-microscopic evidence of permeability of an intact dialysis membrane for hepatitis-b was obtained. concentration of hepatitis-b virus was at least 1 ... | 1977 | 830518 |