Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| emu-bcl10 mice exhibit constitutive activation of both canonical and noncanonical nf-kappab pathways generating marginal zone (mz) b-cell expansion as a precursor to splenic mz lymphoma. | bcl10, required for nuclear factor kappab (nf-kappab) activation during antigen-driven lymphocyte responses, is aberrantly expressed in mucosa-associated lymphoid tissue-type marginal zone (mz) lymphomas because of chromosomal translocations. emu-driven human bcl10 transgenic (tg) mice, which we created and characterize here, had expanded populations of mz b cells and reduced follicular and b1a cells. splenic b cells from tg mice exhibited constitutive activation of both canonical and noncanonic ... | 2009 | 19696203 |
| magnetic poly(pegma-maa) nanoparticles: photochemical preparation and potential application in drug delivery. | poly(pegma-maa)-coated superparamagnetic nanoparticles were synthesized by in situ photochemical polymerization in magnetite aqueous suspension under uv irradiation. the magnetic poly(pegma-maa) nanoparticles were characterized by fourier transform infrared spectroscopy (ft-ir), transmission electron microscopy (tem), photo correlation spectroscopy (pcs) and vibration sample magnetometry (vsm), respectively. the results indicated that the magnetic poly(pegma-maa) nanoparticles were of regularly ... | 2009 | 19723435 |
| protein and albumin-to-creatinine ratios in random urines accurately predict 24 h protein and albumin loss in patients with kidney disease. | random urine protein-to-creatinine (pcr) and albumin-to-creatinine (acr) ratios have been proposed as alternatives to 24 h urine measurements to simplify sample collection and overcome errors. the aim of this study was to examine the ability of pcr and acr to predict urinary 24 h protein and albumin loss, respectively, in patients with kidney disease, and determine the most appropriate time of collection. | 2009 | 19729498 |
| the use of a hypo-osmotic swelling (hos) test on sperm of the pig (sus scrofa domesticus), emu (dromaius novaehollandiae), asian elephant (elephas maximus), hamadryas baboon (papio hamadryas hamadryas), and central rock rat (zyzomys pedunculatus). | a hypo-osmotic swelling test using talp-hepes medium over a range of 50 to 300 mosm/kg was applied to sperm from domestic and endangered species. maximal responses of curling of the sperm tails were seen over a range of osmolalities for epididymal sperm from the pig (100 mosm/kg), hamadryas baboon (range 50-125 mosm/kg), and central rock rat (range 50-100 mosm/kg), and the ejaculated sperm from the emu (50 mosm/kg) and the asian elephant (range 75-150 mosm/kg). a solution of talp-hepes medium at ... | 2009 | 19734955 |
| a role for e2f activities in determining the fate of myc-induced lymphomagenesis. | the phenotypic heterogeneity that characterizes human cancers reflects the enormous genetic complexity of the oncogenic process. this complexity can also be seen in mouse models where it is frequently observed that in addition to the initiating genetic alteration, the resulting tumor harbors additional, somatically acquired mutations that affect the tumor phenotype. to investigate the role of genetic interactions in the development of tumors, we have made use of the emu-myc model of pre-b and b ... | 2009 | 19749980 |
| multi-functional thermosensitive composite microspheres with high magnetic susceptibility based on magnetite colloidal nanoparticle clusters. | monodisperse organic/inorganic composite microspheres with well-defined structure were prepared through the encapsulation of silica coated superparamagnetic magnetite colloidal nanoparticle clusters (cncs) with cross-linked poly(n-isopropylacrylamide) (pnipam) shell. at first, the sub-micrometer-sized cncs were fabricated by the solvothermal process, and then a silica layer was coated on the surface of cncs through a sol-gel process, and finally, a thermoresponsive shell of pnipam was deposited ... | 2010 | 19754089 |
| chronic lymphocytic leukemia of emu-tcl1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic cd257 to accelerate disease progression. | results of heavy-water labeling studies have challenged the notion that chronic lymphocytic leukemia (cll) represents an accumulation of noncycling b cells. we examined leukemia cell turnover in emu-tcl1 transgenic (tcl1-tg) mice, which develop a cll-like disease at 8 to 12 months of age. we found that leukemia cells in these mice not only had higher proportions of proliferating cells but also apoptotic cells than did nonleukemic lymphocytes. we crossed tcl1-tg with baff-tg mice, which express h ... | 2009 | 19755673 |
| investigation of the new p'3-na0.60vo2 phase: structural and physical properties. | a new layered phase na(0.60)vo(2) was synthesized by chemical deintercalation of sodium from the pristine compound o3-navo(2). the na(0.60)vo(2) compound exhibits a distorted p'3-type oxygen stacking (aabbcc) with an average monoclinic unit cell containing a = 4.9862(14) a, b = 2.8708(8) a, c = 5.917(2) a, and beta = 104.36(3) degrees. a modulated structure was observed by transmission electron microscopy and x-ray diffraction (xrd) measurements. indexation of the xrd pattern was achieved by usi ... | 2009 | 19780614 |
| distinctive cell properties of b cells carrying the bcl2 translocation and their potential roles in the development of lymphoma of germinal center type. | the bcl2/igh translocation is a hallmark of follicular lymphoma and germinal center b-cell type diffuse large b-cell lymphoma. although a strong determinant of these histological subtypes, this translocation is insufficient by itself for lymphomagenesis, so that other genetic alterations are required. to clarify how the bcl2 translocation contributes to the development of specific lymphoma subtypes, we used chimeric mouse models and a bone marrow transplantation system to examine the biological ... | 2009 | 19780757 |
| in vivo rnai screening identifies regulators of actin dynamics as key determinants of lymphoma progression. | mouse models have markedly improved our understanding of cancer development and tumor biology. however, these models have shown limited efficacy as tractable systems for unbiased genetic experimentation. here, we report the adaptation of loss-of-function screening to mouse models of cancer. specifically, we have been able to introduce a library of shrnas into individual mice using transplantable emu-myc lymphoma cells. this approach has allowed us to screen nearly 1,000 genetic alterations in th ... | 2009 | 19783987 |
| a novel route in bone tissue engineering: magnetic biomimetic scaffolds. | in recent years, interest in tissue engineering and its solutions has increased considerably. in particular, scaffolds have become fundamental tools in bone graft substitution and are used in combination with a variety of bio-agents. however, a long-standing problem in the use of these conventional scaffolds lies in the impossibility of re-loading the scaffold with the bio-agents after implantation. this work introduces the magnetic scaffold as a conceptually new solution. the magnetic scaffold ... | 2010 | 19788946 |
| repetitive heterocoagulation of oppositely charged particles for enhancement of magnetic nanoparticle loading into monodisperse silica particles. | oppositely charged particles were repetitively heterocoagulated to fabricate highly monodisperse magnetic silica particles with high loading of magnetic nanoparticles. positively charged magnetic nanoparticles prepared by surface modification with n-trimethoxysilylpropyl-n,n,n-trimethylammonium chloride (tsa) were used to heterocoagulate with silica particles under basic conditions to give rise to negative silica surface charge and prevent the oxidation of the magnetic nanoparticles. the resulta ... | 2010 | 19824685 |
| photmicrography of urinary deposits in stone clinic. | the importance of routine urine deposit study has not been projected satisfactorily in literature. this paper analyses the findings of urine microscopy of urinary stone patients who attended the stone clinic. a total number of 800 patients who attended the urinary stone clinic during the years 2005-2007 were selected for the study. each patient had two samples of urine studied; early morning urine (emu) and random. the patients were classified into different groups as proved stone patients (304) ... | 2009 | 19834702 |
| improved computational performance of mfa using elementary metabolite units and flux coupling. | extending the scope of isotope mapping models becomes increasingly important in order to analyze strains and drive improved product yields as more complex pathways are engineered into strains and as secondary metabolites are used as starting points for new products. here we present how the elementary metabolite unit (emu) framework and flux coupling significantly decrease the computational burden of metabolic flux analysis (mfa) when applied to large-scale metabolic models. we applied these tech ... | 2010 | 19837183 |
| msh2-dependent dna repair mitigates a unique susceptibility of b cell progenitors to c-myc-induced lymphomas. | c-myc is one of the most common targets of genetic alterations in human cancers. although overexpression of c-myc in the b cell compartment predisposes to lymphomas, secondary mutations are required for disease manifestation. in this article, we show that genetic deficiencies causing arrested b cell development and accumulation of b cell progenitors lead to accelerated lymphomagenesis in emu c-myc transgenic mice. this result suggests that b cell progenitors are more prone than their mature coun ... | 2009 | 19837692 |
| gum arabic-coated magnetic nanoparticles for potential application in simultaneous magnetic targeting and tumor imaging. | magnetic iron oxide nanoparticles (mnp) coated with gum arabic (ga), a biocompatible phytochemical glycoprotein widely used in the food industry, were successfully synthesized and characterized. ga-coated mnp (ga-mnp) displayed a narrow hydrodynamic particle size distribution averaging about 100 nm; a ga content of 15.6% by dry weight; a saturation magnetization of 93.1 emu/g fe; and a superparamagnetic behavior essential for most magnetic-mediated applications. the ga coating offers two major b ... | 2009 | 19842043 |
| involvement of rhoh gtpase in the development of b-cell chronic lymphocytic leukemia. | rhoh is a hematopoietic-specific, gtpase-deficient member of the rho gtpase family that functions as a regulator of thymocyte development and t-cell receptor signaling by facilitating localization of zeta-chain-associated protein kinase 70 (zap70) to the immunological synapse. here we investigated the function of rhoh in the b-cell lineage. b-cell receptor (bcr) signaling was intact in rhoh(-/-) mice. because rhoh interacts with zap70, which is a prognostic factor in b-cell chronic lymphocytic l ... | 2010 | 19847197 |
| ontogeny of long bone geometry in capuchin monkeys (cebus albifrons and cebus apella): implications for locomotor development and life history. | studies of a diverse array of animals have found that young individuals often have robust bones for their body size (i.e. augmented cross-sectional dimensions), limiting fracture risk despite general musculoskeletal immaturity. however, previous research has focused primarily on precocial taxa (e.g. rodents, lagomorphs, bovids, goats and emu). in this study, we examined the ontogenetic scaling of humeral and femoral cross-sectional robusticity in a mixed-longitudinal sample of two slow-growing, ... | 2010 | 19864273 |
| the excurrent ducts of the testis of the emu (dromaius novaehollandiae) and ostrich (struthio camelus): microstereology of the epididymis and immunohistochemistry of its cytoskeletal systems. | the volumetric proportion of the various ducts of the epididymis of the emu and ostrich and the immunohistochemistry of actin microfilaments, as well as cytokeratin, desmin and vimentin intermediate filaments, were studied in the various ducts of the epididymis of the emu and ostrich. the volumetric proportions of various ducts, which are remarkably different from those of members of the galloanserae monophyly, are as follows: the rete testis, 5.2 +/- 1.4% for the emu and 2.4 +/- 1.8% for the os ... | 2010 | 19874278 |
| carbon nanostraws: nanotubes filled with superparamagnetic nanoparticles. | a two-step magnetically assisted capillary action method is demonstrated as a facile technique to produce hollow carbon nanotubes filled with uniformly dispersed fe3o4 nanoparticles (nps). template-assisted chemical vapor deposition (cvd) grown cnts with average diameter 200-300 nm and length 5-6 microm were effectively used as 'nanostraws' to suck in chemically synthesized fe3o4 nanoparticles (mean size approximately 6 nm) in a ferrofluid suspension. temperature and magnetic field-dependent dc ... | 2009 | 19880982 |
| facile preparation of superparamagnetic fe3o4/poly(st-co-mps)/sio2 composite particles with high magnetization by introduction of silanol groups. | fe3o4/poly(st-co-mps) particles were prepared by encapsulation of fe3o4 nanoparticles into copolymers of styrene (st) and 3-trimethoxysilylpropylmethacrylate (mps) (poly(st-co-mps)) prepared by miniemulsion copolymerization. it is found that the structure of the fe3o4/poly(st-co-mps)/sio2 composite particles prepared by direct silica deposition on surface of the fe3o4/poly(st-co-mps) particles is dependent on the volume fraction of mps used in the copolymerization. it is identified that the surf ... | 2009 | 19908468 |
| magnetic studies of cofe2o4/sio2 aerogel and xerogel nanocomposites. | the evolution of the structural and magnetic properties of nanocomposites formed by cobalt ferrite particles dispersed in xerogel and aerogel silica matrices (cofe2o4/sio2) have been studied as a function of the temperature of preparation and the amount of ferrite dispersed in the matrix. wet samples with different amounts of cofe2o4 in sio2 matrix were prepared by sol-gel process in monolithic form. xerogel and aerogel samples were prepared by controlled and hypercritical drying, respectively, ... | 2009 | 19908477 |
| room temperature ferromagnetism in fe-doped ceo2 nanoparticles. | rt ferromagnetism was observed in nanoparticles of fe-doped ceo2 (i.e., ce(0.97)fe(0.03)o2) synthesized by a sol-gel method. the undoped and fe-doped ceo2 were characterized by xrd, raman spectroscopy, tem, and vsm. the undoped samples and ce(0.97)fe(0.03)o2 precursor exhibit a diamagnetic behavior. the 673 k-calcined ce(0.97)fe(0.03)o2 sample is paramagnetic whereas 773 and 873 k-calcined ce(0.97)fe(0.03)o2 samples are ferromagnetism having the magnetizations of 4.65 x 10(-3) emu/g and 6.20 x 1 ... | 2009 | 19908543 |
| x-ray magnetic circular dichroism and small angle neutron scattering studies of thiol capped gold nanoparticles. | x-ray magnetic circular dichroism (xmcd) and small angle neutron scattering (sans) measurements were performed on thiol capped au nanoparticles (nps) embedded into polyethylene. an xmcd signal of 0.8 x 10(-4) was found at the au l3 edge of thiol capped au nps embedded in a polyethylene matrix for which superconducting quantum interference device (squid) magnetometry yielded a saturation magnetization, m(s), of 0.06 emu/g(au). sans measurements showed that the 3.2 nm average-diameter nanoparticle ... | 2009 | 19908546 |
| preparation of monodisperse magnetic polymer microspheres by swelling and thermolysis technique. | a novel process for the preparation of monodisperse magnetic polymer microspheres by uniquely combining swelling and thermolysis technique was reported. the monodisperse polystyrene microspheres were first prepared by dispersion polymerization and swelled in chloroform. then, ferric oleate was dispersed in chloroform as a precursor and impregnated into the swollen polymer microspheres. subsequently, the iron oxide nanoparticles were formed within the polymer matrix by thermal decomposition of fe ... | 2010 | 19908847 |
| electrical conductivity and total dissolved solids in urine. | the objective of this paper is to study the relevance of electrical conductivity (ec) and total dissolved solids (tds) in early morning and random samples of urine of urinary stone patients; 2,000 urine samples were studied. the two parameters were correlated with the extent of various urinary concrements. the early morning urine (emu) and random samples of the patients who attended the urinary stone clinic were analysed routinely. the ph, specific gravity, ec, tds, redox potential, albumin, sug ... | 2010 | 19921168 |
| ictal spect using an attachable automated injector: clinical usefulness in the prediction of ictal onset zone. | ictal single-photon emission computed tomography (spect) is a valuable method for localizing the ictal onset zone in the presurgical evaluation of patients with intractable epilepsy. conventional methods used to localize the ictal onset zone have problems with time lag from seizure onset to injection. | 2009 | 19922314 |
| synthesis and magnetic properties of fe3o4 nanoparticles coated with biocompatible double hydrophilic block copolymer. | fe3o4 nanoparticles coated with double hydrophilic biocompatible poly(sodium(2-sulfamate-3-carboxylate)isoprene)-b-poly(ethylene oxide) block copolymer were prepared by a one step precipitation method. the magnetic nanoparticles have 15 nm mean diameter (tem), 68 nm hydrodynamic diameter, -30.10 mv zeta-potential and form very stable dispersion in aqueous media. structural characterization using powder xrd and mössbauer spectroscopy establish the magnetite phase, while thermogravimetric analysis ... | 2009 | 19928145 |
| magnetic properties of iron particles embedded in multiwall carbon nanotubes. | iron nanoparticles are embedded in multiwall carbon nanotubes by the chemical vapor deposition, where benzene and ferrocene are taken as precursor materials. varying quantity of iron particles are embedded in these tubes by taking different amount of ferrocene. these particles exhibit a magnetic moment up to 98 emu/g and an enhanced coercivity in the range of 500-2000 oe. negative magnetoresistance approximately 10% is observed in the presence of magnetic field up to 11 t applied at various temp ... | 2009 | 19928233 |
| p53-dependent senescence delays emu-myc-induced b-cell lymphomagenesis. | the effect of p53-dependent cell-cycle arrest and senescence on emu-myc-induced b-cell lymphoma development remains controversial. to address this question, we crossed emu-myc mice with the p53(515c) mutant mouse, encoding the mutant p53r172p protein that retains the ability to activate the cell-cycle inhibitor and senescence activator p21. importantly, this mutant lacks the ability to activate p53-dependent apoptotic genes. hence, emu-myc mice that harbor two p53(515c) alleles are completely de ... | 2010 | 19935700 |
| mcl-1-dependent leukemia cells are more sensitive to chemotherapy than bcl-2-dependent counterparts. | myeloid cell leukemia sequence 1 (mcl-1) and b cell leukemia/lymphoma 2 (bcl-2) are anti-apoptotic proteins in the bcl-2 protein family often expressed in cancer. to compare the function of mcl-1 and bcl-2 in maintaining cancer survival, we constructed complementary mouse leukemia models based on emu-myc expression in which either bcl-2 or mcl-1 are required for leukemia maintenance. we show that the principal anti-apoptotic mechanism of both bcl-2 and mcl-1 in these leukemias is to sequester pr ... | 2009 | 19948485 |
| preparation, characterization, in vivo and in vitro studies of arsenic trioxide mg-fe ferrite magnetic nanoparticles. | mgfe(2)o(4) magnetic nanoparticle composed of as(2)o(3) (as(2)o(3)-mnps) were prepared and their in vitro and in vivo characteristics were studied. | 2009 | 19960013 |
| suppression of b-cell lymphomagenesis by the bh3-only proteins bmf and bad. | oncogenic c-myc is known to balance excessive proliferation by apoptosis that can be triggered by p53-dependent and p53-independent signaling networks. here, we provide evidence that the bh3-only proapoptotic bcl-2 family members bcl-2 modifying factor (bmf) and bcl-2 antagonist of cell death (bad) are potent antagonists of c-myc-driven b-cell lymphomagenesis. tumor formation was preceded by the accumulation of preneoplastic pre-b and immature immunoglobulin m-positive (igm(+)) b cells in hemato ... | 2010 | 19965635 |
| nanobeads highly loaded with superparamagnetic nanoparticles prepared by emulsification and seeded-emulsion polymerization. | functional superparamagnetic colloids possessing high saturation magnetization are prepared by emulsification of superparamagnetic nanoparticles (spm nps) and heterogeneous polymerization. the colloids consist of a core of densely packed nps encapsulated within a thin polymer shell. the cores are made by emulsifying spm nps and toluene into an aqueous surfactant solution, and subsequently condensing the emulsion droplets by removal of the solvent generating clusters of spm nps. by tuning the emu ... | 2010 | 20000392 |
| controlled synthesis of iron oxide nanoparticles over a wide size range. | we report on the effect of using decanoic acid as capping ligand on the synthesis of iron oxide nanoparticles by thermal decomposition of an organic iron precursor in organic medium. this procedure allowed us to control the particle size within 5 nm and about 30 nm by modifying the precursor-to-capping ligand ratio in a systematic fashion and to further expand the particle size range up to about 50 nm by adjusting the final synthesis temperature. the nanoparticles also showed high saturation mag ... | 2010 | 20000725 |
| malignant transformation of slp65-deficient pre-b cells involves disruption of the arf-mdm2-p53 tumor suppressor pathway. | the adapter protein slp65 is a key component of the precursor-b (pre-b) cell receptor. slp65-deficient mice spontaneously develop pre-b cell leukemia, but the mechanism by which slp65(-/-) pre-b cells become malignant is unknown. loss of btk, a tec-family kinase that cooperates with slp65 as a tumor suppressor, synergizes with deregulation of the c-myc oncogene during lymphoma formation. here, we report that the presence of the immunoglobulin heavy chain transgene v(h)81x prevented tumor develop ... | 2010 | 20008789 |
| autonomic control of heart rate and its variability during normoxia and hypoxia in emu (dromaius novaehollandiae) hatchlings. | heart rate variability is a common feature of the vertebrate cardiovascular system and is a consequence of variable input from the sympathetic and parasympathetic branches of the autonomic nervous system. the aim of this study was to examine the role of the autonomic nervous system in regulating heart rate and heart rate variability in 1-d-old emu hatchlings in normoxia and during exposure to 10% o2. the role of the autonomic nervous system in controlling emu heart rate and its variability was e ... | 2010 | 20008811 |
| mir-19 is a key oncogenic component of mir-17-92. | recent studies have revealed the importance of multiple micrornas (mirnas) in promoting tumorigenesis, among which mir-17-92/oncomir-1 exhibits potent oncogenic activity. genomic amplification and elevated expression of mir-17-92 occur in several human b-cell lymphomas, and enforced mir-17-92 expression in mice cooperates with c-myc to promote the formation of b-cell lymphomas. unlike classic protein-coding oncogenes, mir-17-92 has an unconventional gene structure, where one primary transcript y ... | 2009 | 20008935 |
| il-6 and myc collaborate in plasma cell tumor formation in mice. | interleukin-6 (il-6) plays a critical role in the natural history of human plasma cell neoplasms (pcns), such as plasma cell myeloma and plasmacytoma (pct). il-6 is also at the center of neoplastic plasma cell transformation in balb/c (c) mice carrying a transgene, h2-l(d)-il6, that encodes human il-6 under control of the major histocompatibility complex h2-l(d) promoter: strain c.h2-l(d)-il6. these mice are prone to pct, but tumor development is incomplete with long latencies ( approximately 40 ... | 2010 | 20018915 |
| the preparation of magnetically guided lipid based nanoemulsions using self-emulsifying technology. | this paper reports an easy and highly reproducible preparation route, using self-emulsifying technology, for an orally administered high quality magnetically responsive drug delivery system. hydrophobic iron oxide nanoparticles of about 5 nm in diameter were prepared and incorporated into the lipid core of the produced oil droplets of a self-nanoemulsifying drug delivery system (magc(18)/snedds). the produced nanoemulsion exhibits colloidal stability at high ionic strengths and temperatures. the ... | 2010 | 20032554 |
| replacement of imu-cmu intron by neor gene alters imu germ-line expression but has no effect on v(d)j recombination. | the neor gene has often been used to unravel the mechanisms underlying long-range interactions between promoters and enhancers during v(d)j assembly and class switch recombination (csr) in the immunoglobulin heavy chain (igh) locus. this approach led to the notion that csr is regulated through competition of germ-line (gl) promoters for activities displayed by the 3' regulatory region (3'rr). this polarized long-range effect of the 3'rr is disturbed upon insertion of neor gene in the igh constan ... | 2010 | 20036775 |
| [preparation, characterization and property of bamboo-like alpha-fe2 o3 nanobars]. | firstly, hydroxide iron precursor was prepared by the co-precipitation method through using nitric iron as the source of iron, ammonia as precipitants, and poly-glycol as dispersant. secondly, the precursor was calcined at 450 degrees c for 2 h under the protection of nitrogen. finally, the images and structures of resultant powders were investigated by transmission electron microscopes (tem), x-ray diffraction (xrd), raman spectrum and the near-edge x-ray absorption fine structure (nexafs), res ... | 2009 | 20038080 |
| transient improvement after brief antiepileptic drug withdrawal in the epilepsy monitoring unit--possible relationship to aed tolerance. | a drug holiday seems to produce seizure interval prolongation (sip) after reinstitution of antiepileptic drugs (aeds). this effect was demonstrated mainly with carbamazepine. we evaluated sip with newer aeds and tested the relationship of sip to history of aed tolerance. | 2010 | 20067500 |
| how common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures? | autonomic effects of seizures, including cardiorespiratory abnormalities, may be involved in sudden unexpected death in epilepsy (sudep). the purpose of this study was to determine the prevalence and risk factors for ictal hypoxemia (oxygen saturation <90%) and ictal bradycardia (heart rate < second percentile for age) in children during recorded seizures. | 2010 | 20067502 |
| fragmentation channels in dissociative electron recombination with hydronium and other astrophysically important species. | we report on our recent studies of dissociative recombination (dr) employing two different fragment imaging detection techniques at the tsr storage ring in heidelberg, germany. principles of an upgraded 3d optical system and the new energy-sensitive multistrip detector (emu) are explained together with possible applications in reaction dynamics studies. with the emu imaging detector we succeeded to observe the branching ratios after dr of deuterated hydronium ions d(3)o(+) at energies of 0-0.5 a ... | 2010 | 20073483 |
| b cell-specific lentiviral gene therapy leads to sustained b-cell functional recovery in a murine model of x-linked agammaglobulinemia. | the immunodeficiency disorder, x-linked agammaglobulinemia (xla), results from mutations in the gene encoding bruton tyrosine kinase (btk). btk is required for pre-b cell clonal expansion and b-cell antigen receptor signaling. xla patients lack mature b cells and immunoglobulin and experience recurrent bacterial infections only partially mitigated by life-long antibody replacement therapy. in pursuit of definitive therapy for xla, we tested ex vivo gene therapy using a lentiviral vector (lv) con ... | 2010 | 20093406 |
| the mouse immunoglobulin heavy chain v-d intergenic sequence contains insulators that may regulate ordered v(d)j recombination. | during immunoglobulin heavy chain (igh) v(d)j recombination, d to j precedes v to dj recombination in an ordered manner, controlled by differential chromatin accessibility of the v and dj regions and essential for correct antibody assembly. however, with the exception of the intronic enhancer emu, which regulates d to j recombination, cis-acting regulatory elements have not been identified. we have assembled the sequence of a strategically located 96-kb v-d intergenic region in the mouse igh and ... | 2010 | 20100833 |
| growth and sculpting of co nano-strings on si micro-cantilevers: magneto-mechanical properties. | si micro-cantilevers were coated with co nano-strings, which were simultaneously grown and sculpted during off-normal pulsed laser deposition. the surface morphology of micro-cantilevers with longitudinal or transverse nano-strings was analysed by scanning tunnelling microscopy. magnetic anisotropy was detected with a magnetization direction parallel to the nano-strings. the two micro-cantilever types exhibited different mechanical behaviours when placed in a non-uniform magnetic field. by varyi ... | 2010 | 20124658 |
| nanostructured multifunctional electromagnetic materials from the guest-host inorganic-organic hybrid ternary system of a polyaniline-clay-polyhydroxy iron composite: preparation and properties. | a nanostructured electromagnetic polyaniline-polyhydroxy iron-clay composite (ppic) was prepared by oxidative radical emulsion polymerization of aniline in the presence of polyhydroxy iron cation (pic) intercalated clays. morphological observation through sem, tem, and afm suggested the formation of self-assembled nanospheres of pic with self-assembled pani engulfed over pic, and the presence of iron in ppic was confirmed by the eds analysis. xrd studies revealed that ppic are comprised of exfol ... | 2010 | 20136090 |
| water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging. | we report here a thermal decomposition approach to the synthesis of water-soluble superparamagnetic manganese ferrite (mnfe(2)o(4)) nanoparticles (nps) for magnetic resonance (mr) imaging applications. in this approach, tetraethylene glycol was utilized as a coordination and stabilization agent, rendering the nps water-soluble and stable. the formed nps had a diameter of 7 nm with a narrow size distribution, and were superparamagnetic with a saturated magnetization (ms) of 39 emu/g. in vitro cyt ... | 2010 | 20144480 |
| gold hybrid nanoparticles for targeted phototherapy and cancer imaging. | gold and iron oxide hybrid nanoparticles (hnps) synthesized by the thermal decomposition technique are bio-functionalized with a single chain antibody, scfv, that binds to the a33 antigen present on colorectal cancer cells. the hnp-scfv conjugates are stable in aqueous solution with a magnetization value of 44 emu g(-1) and exhibit strong optical absorbance at 800 nm. here we test this material in targeting, imaging and selective thermal killing of colorectal cancer cells. cellular uptake studie ... | 2010 | 20154383 |
| chitosan-coated octadecyl-functionalized magnetite nanoparticles: preparation and application in extraction of trace pollutants from environmental water samples. | in the present study, chitosan-coated octadecyl-functionalized magnetite nanoparticles (fe(3)o(4)-c(18)-chitosan mnps) are synthesized and used as an adsorbent to extract trace analytes from environmental water samples. the magnetic nanoparticles, 20 nm in diameter, are of uniform size and have a high magnetic saturation value of 52 emu g(-1), which endue the adsorbent with a large surface area and convenience of isolation. the anionic pollutants, perfluorinated compounds (pfcs), are trapped by ... | 2010 | 20155948 |
| nanoscale assembly of amine functionalized colloidal iron oxide. | we demonstrate a single-step facile approach for highly water stable assembly of amine-functionalized fe(3)o(4) nanoparticles using thermal decomposition of fe-chloride precursors in ethylene glycol medium in the presence of ethylenediamine. the average size of nanoassemblies is 40±1 nm, wherein the individual nanoparticles are about 6 nm. amine functionalized properties are evident from ftir, thermal and elemental analysis. the saturation magnetization and spin-echo r(2) of the nanoassemblies w ... | 2009 | 20160860 |
| a facile hydrothermal synthesis of iron oxide nanoparticles with tunable magnetic properties. | we report a facile one-step hydrothermal approach to the synthesis of iron oxide (fe(3)o(4)) nanoparticles (nps) with controllable diameters, narrow size distribution, and tunable magnetic properties. in this approach, the iron oxide nps were fabricated by oxidation of fecl(2)·4h(2)o in basic aqueous solution under an elevated temperature and pressure. transmission electron microscopy (tem) and x-ray diffraction (xrd) studies reveal that the particles are highly crystalline and that the diameter ... | 2009 | 20174618 |
| biomass accumulation and energy conversion efficiency in aromatic rice genotypes. | a field experiment was conducted to evaluate photosynthetic efficiency along with different growth parameters of aromatic rice genotypes. forty genotypes including three non-aromatic checks exhibited enormous variations for leaf area index (lai), crop growth rate (cgr), relative growth rate (rgr), net assimilation rate (nar), grain yield, total dry matter, harvest index and photosynthetic efficiency or energy use efficiency (emu) at panicle initiation and heading stages. minimum lai-value was 0. ... | 2010 | 20176338 |
| skp2 directs myc-mediated suppression of p27kip1 yet has modest effects on myc-driven lymphomagenesis. | the universal cyclin-dependent kinase inhibitor p27(kip1) functions as a tumor suppressor, and reduced levels of p27(kip1) connote poor prognosis in several human malignancies. p27(kip1) levels are predominately regulated by ubiquitin-mediated turnover of the protein, which is marked for destruction by the e3 ubiquitin ligase scf(skp2) complex following its phosphorylation by the cyclin e-cyclin-dependent kinase 2 complex. binding of phospho-p27(kip1) is directed by the skp2 f-box protein, and t ... | 2010 | 20197382 |
| severe snakebites in northern kwazulu-natal: treatment modalities and outcomes. | we aimed to study the outcomes of severe snakebites in patients admitted to ngwelezana hospital in north-eastern kwazulu-natal, the seasonal variations, and the effectiveness and complications of antivenom. | 2009 | 20218483 |
| fossil avian eggshell preserves ancient dna. | owing to exceptional biomolecule preservation, fossil avian eggshell has been used extensively in geochronology and palaeodietary studies. here, we show, to our knowledge, for the first time that fossil eggshell is a previously unrecognized source of ancient dna (adna). we describe the successful isolation and amplification of dna from fossil eggshell up to 19 ka old. adna was successfully characterized from eggshell obtained from new zealand (extinct moa and ducks), madagascar (extinct elephant ... | 2010 | 20219731 |
| tumor stroma-derived tgf-beta limits myc-driven lymphomagenesis via suv39h1-dependent senescence. | activated ras/braf oncogenes induce cellular senescence as a tumor-suppressive barrier in early cancer development, at least in part, via an oncogene-evoked dna damage response (ddr). in contrast, myc activation-although producing a ddr as well-is known to primarily elicit an apoptotic countermeasure. using the emu-myc transgenic mouse lymphoma model, we show here in vivo that apoptotic lymphoma cells activate macrophages to secrete transforming growth factor beta (tgf-beta) as a critical non-ce ... | 2010 | 20227040 |
| preparation of a chitosan-coated c(18)-functionalized magnetite nanoparticle sorbent for extraction of phthalate ester compounds from environmental water samples. | novel superparamagnetic chitosan-coated c(18)-functionalized magnetite nanoparticles (mnps) were successfully synthesized and applied as an effective sorbent for the preconcentration of several typical phthalate ester compounds from environmental water samples. the mnps were 20 nm in diameter and had a high magnetic saturation value (52 emu g(-1)), which endowed the sorbent with a large surface area and the convenience of isolation from water samples. phthalate esters could be extracted by the i ... | 2010 | 20229007 |
| room-temperature ferromagnetism and the scaling relation between magnetization and average granule size in nanocrystalline zn/zno core-shell structures prepared by sputtering. | ferromagnetism is found in nanocrystalline zn/zno core-shell structures prepared by sputtering pure zn with subsequent oxidation. the saturation magnetization (m(s)) of the passivated zno shells increases with decrease in average particle size (d). the curie temperature of the samples is above 400 degrees c. it is found that the ferromagnetism has a close relationship with point defects in zno shells. the maximum magnetization is estimated to be 28 emu cm(-3) (i.e. 0.14 mu(b) per unit cell) at 3 ... | 2010 | 20234078 |
| some physicochemical properties of the three albumin layers of the chicken, goose and emu eggs. | 1947 | 20247649 | |
| improvement in cardiac function with small intestine extracellular matrix is associated with recruitment of c-kit cells, myofibroblasts, and macrophages after myocardial infarction. | this study tested the hypothesis that modulation of angiogenesis and cardiac function by injecting small intestine extracellular matrix emulsion (emu) into myocardium is associated with recruitment of c-kit cells, myofibroblasts, and macrophages after myocardial infarction. | 2010 | 20298933 |
| a deficiency in mdm2 binding protein inhibits myc-induced b-cell proliferation and lymphomagenesis. | mdm2 binding protein (mtbp) has been implicated in cell-cycle arrest and the mdm2/p53 tumor suppressor pathway through its interaction with mdm2. to determine the function of mtbp in tumorigenesis and its potential role in the mdm2/p53 pathway, we crossed mtbp-deficient mice to emu-myc transgenic mice, in which overexpression of the oncogene c-myc induces b-cell lymphomas primarily through inactivation of the mdm2/p53 pathway. we report that myc-induced b-cell lymphoma development in mtbp hetero ... | 2010 | 20305689 |
| hydrothermal microemulsion synthesis of oxidatively stable cobalt nanocrystals encapsulated in surfactant/polymer complex shells. | air-stable magnetic cobalt nanocrystals have been conveniently prepared via a reverse micellar synthesis, followed by a hydrothermal treatment. the synthesis was carried out by first mixing an aqueous solution containing cobalt chloride and poly(sodium 4-styrenesulfonate) (pss) with an organic mixture containing cetyltrimethylammonium bromide (ctab) to form reverse micelles, followed by reducing cobalt ions with sodium borohydride. the resultant nanoparticles were then undergone a hydrothermal t ... | 2010 | 20337480 |
| gross morphology of the intra-oral rhamphotheca, oropharynx and proximal oesophagus of the emu (dromaius novaehollandiae). | information on the gross morphology of the upper digestive tract of ratites is sparse. this is an important region considering that it is the first area for food selection and intake which is vital to the nutrition and growth of the animal and therefore its commercial viability. twenty-three heads from sub-adult (12-14 months) emus were used to provide a definitive description of the oropharynx and proximal oesophagus. besides supplying baseline morphological data of veterinary importance, this ... | 2010 | 20353488 |
| the antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling. | sertraline, a selective serotonin reuptake inhibitor, is a widely used antidepressant agent. here, we show that sertraline also exhibits antiproliferative activity. exposure to sertraline leads to a concentration-dependent decrease in protein synthesis. moreover, polysome profile analysis of sertraline-treated cells shows a reduction in polysome content and a concomitant increase in 80s ribosomes. the inhibition in translation caused by sertraline is associated with decreased levels of the eukar ... | 2010 | 20354178 |
| improving the anti-tumor effect of genistein with a biocompatible superparamagnetic drug delivery system. | the practical application of genistein as a low toxicity chemotherapeutic drug is hindered by many of its in vivo properties. to overcome these obstacles, a new multifunctional drug delivery system is developed, which is based on covalently attaching genistein onto fe3o4 nanoparticles coated by cross-linked carboxymethylated chitosan (cmch). the structure of the fe3o4-cmch-genistein nano-conjugate was confirmed by transmission electron micrographs (tem), x-ray diffraction (xrd) and fourier-trans ... | 2010 | 20355429 |
| magnetically responsive phase-change microspheres with large magnetization using ferrite nanoparticles. | magnetically responsive phase-change microspheres were prepared and studied in this article. in the synthetic process, oleic acid was used to modify the iron oxide nanoparticles. the ferrite nanoparticles, about 10 nm in diameter, were highly dispersed due to the oleic acid on the surface of the particles, and they were encapsulated in polymethyl methacrylate (pmma) by microemulsion polymerization with paraffin, which could be presumed from the differential scanning calorimetry (dsc) curves. acc ... | 2010 | 20355566 |
| magnetic properties of fe(x)pt(y)au(100-x-y) nanoparticles. | fe(x)pt(y)au(100-x-y) nanoparticles of size 3.5 nm were prepared by polyol reduction of platinum acetylacetonate and gold acetate and the thermal decomposition of iron pentacarbonyl. the as-synthesized nanoparticles with disordered fcc structure were then heat treated to transform to the l1(0) structure with high magnetocrystalline anisotropy. by tuning the stoichiometry of the fe(x)pt(y)au(100-x-y) nanoparticles, the phase transition temperature was reduced by more than 200 degrees c. after the ... | 2010 | 20358888 |
| facile synthesis of porous fe7co3/carbon nanocomposites and their applications as magnetically separable adsorber and catalyst support. | a facile co-gelation route has been developed to synthesize novel porous fe(7)co(3)/carbon composites with fe(7)co(3) nanoparticles embedded in the porous carbon matrix. the sol-gel process of this route simultaneously involves the hydrolysis of tetraethylorthosilicate (teos) and the polymerization of furfuryl alcohol (fa) within an ethanol solution containing teos, fa, and metal nitrates, which led to the inorganic/organic hybrid xerogel, accompanying metal salts spontaneously captured in the x ... | 2010 | 20369845 |
| orally administered emu oil decreases acute inflammation and alters selected small intestinal parameters in a rat model of mucositis. | mucositis resulting from cancer chemotherapy is a serious disorder of the alimentary tract. emu oil has demonstrated anti-inflammatory properties in animal models of arthritis and wound healing; however, its effects on the intestine remain unknown. we investigated emu oil for its potential to decrease the severity of mucositis in a rat model. female dark agouti rats (110-150 g) were orogastrically gavaged with emu oil (0.5 or 1 ml) or water (1 ml) for 5 d before intraperitoneal injection of 5-fl ... | 2010 | 20377926 |
| ectopic expression of wild-type fgfr3 cooperates with myc to accelerate development of b-cell lineage neoplasms. | the t(4;14) translocation in multiple myeloma (mm) simultaneously dysregulates two apparent oncogenes: fibroblast growth factor receptor 3 (fgfr3) controlled by the 3' immunoglobulin heavy chain enhancer on der(14) and mmset controlled by the intronic emu enhancer on der(4). although all mm tumors and cell lines with a t(4;14) translocation have dysregulated mmset, about 25% do not express fgfr3. therefore, the function of dysregulated wild-type (wt) fgfr3 in the pathogenesis of mm remains uncle ... | 2010 | 20393505 |
| magnetic silica-coated sub-microspheres with immobilized metal ions for the selective removal of bovine hemoglobin from bovine blood. | magnetic silica-coated magnetite (fe(3)o(4)) sub-microspheres with immobilized metal-affinity ligands are prepared for protein adsorption. first, magnetite sub-microspheres were synthesized by a hydrothermal method. then silica was coated on the surface of fe(3)o(4) particles using a sol-gel method to obtain magnetic silica sub-microspheres with core-shell morphology. next, the trichloro(4-chloromethylphenyl) silane was immobilized on them, reacted with iminodiacetic acid (ida), and charged with ... | 2010 | 20397183 |
| should metapopulation restoration strategies increase patch area or number of patches? | managers of species that exist as metapopulations are faced with many decisions. in this paper we use a decision-theory framework to examine a fundamental management question: should we focus on decreasing the local extinction probability of subpopulations by increasing the size of their patch, or should metapopulation viability be improved by constructing more patches? using a spatially implicit stochastic metapopulation model and stochastic dynamic programming (sdp), we found the optimal solut ... | 2010 | 20405807 |
| nf-kappab/stat3/pi3k signaling crosstalk in imyc e mu b lymphoma. | myc is a well known driver of lymphomagenesis, and myc-activating chromosomal translocation is the recognized hallmark of burkitt lymphoma, an aggressive form of non-hodgkin's lymphoma. we developed a model that mimics this translocation event by inserting a mouse myc cdna gene into the immunoglobulin heavy chain locus, just upstream of the intronic emu enhancer. these mice, designated imyc e mu, readily develop b-cell lymphoma. to study the mechanism of myc-induced lymphoma, we analyzed signali ... | 2010 | 20433747 |
| vibrating coil magnetometer for milli-kelvin temperatures. | we report the development of a vibrating coil magnetometer (vcm) as combined with a top-loading dilution refrigerator for measurements of the magnetization down to millikelvin temperatures. the vcm offers unique measurement conditions, notably efficient cooling of the sample, data collection in uniform magnetic fields, the possibility to study strong magnetic anisotropies, fast data collection over a very wide range of magnetic fields, and the possibility of fast sample changes. in first measure ... | 2010 | 20441354 |
| peg-modified goldmag nanoparticles (pgmns) combined with the magnetic field for local drug delivery. | polyethylene glycol-modified goldmag nanoparticles (pgmns) were synthesized and characterized by several analysis including transmission electron microscopy, dynamic light scattering, fourier transform infrared spectroscopy, and vibrating sample magnetometer. here, we showed that the composite nanoparticles have a saturated magnetization of 34 emu/g with an average diameter of 50 nm. the kinetics analysis showed the maximum doxorubicin (dox) loading capacity of pgmns is 107.78 mg/g. the pgmns lo ... | 2011 | 20465360 |
| observation of magnetic ordering for layered (2-d) potassium diruthenium tetracarbonate, k3[ru(ii/iii)2(o2co)4]: a rare second row transition metal-based magnet. | the detailed magnetic behavior of k(3)[ru(2)(co(3))(4)].xh(2)o (x = 2) reveals that it has a 2-k magnetization at 5 t of 11 125 emu oe/mol, a 50-oe coercive field, and a remnant magnetization of 670 emu oe/mol. it magnetically orders as a canted ferrimagnet below 4.2 k, and is a rare example of a magnetically ordered material based on a second row transition metal. the magnetic ordering confirms that the s not equal to 0 m(ii) site that bridges the layers in previously reported h(x)k(1-x)m(ii)-[ ... | 2010 | 20481600 |
| endothelial delivery of antioxidant enzymes loaded into non-polymeric magnetic nanoparticles. | antioxidant enzymes have shown promise as a therapy for pathological conditions involving increased production of reactive oxygen species (ros). however the efficiency of their use for combating oxidative stress is dependent on the ability to achieve therapeutically adequate levels of active enzymes at the site of ros-mediated injury. thus, the implementation of antioxidant enzyme therapy requires a strategy enabling both guided delivery to the target site and effective protection of the protein ... | 2010 | 20483366 |
| loss of p73 promotes dissemination of myc-induced b cell lymphomas in mice. | mice engineered to express c-myc in b cells (emu-myc mice) develop lethal lymphomas in which the gene encoding the p53 tumor suppressor is frequently mutated. whether the p53 homolog p73 also functions as a tumor suppressor in vivo remains controversial. here we have shown that p73 loss does not substantially affect disease onset and mortality in emu-myc mice. however, it does alter the phenotype of the disease. specifically, p73 loss decreased nodal disease and increased widespread extranodal d ... | 2010 | 20484818 |
| surface morphology of the emu (dromaius novaehollandiae) tongue. | despite numerous morphological studies on the avian tongue, very little meaningful information is currently available on the surface features of this organ using scanning electron microscopy (sem). the only sem description of a ratite tongue is that of the ostrich, although the descriptions are brief and superficial. this sem study of the emu tongue confirms and compliments the comprehensive macroscopic and histological data available for this commercially important species. the tongues of five ... | 2010 | 20491751 |
| polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administration. | this study aimed to examine the applicability of polyethyleneimine (pei)-modified magnetic nanoparticles (gpei) as a potential vascular drug/gene carrier to brain tumors. in vitro, gpei exhibited high cell association and low cell toxicity--properties which are highly desirable for intracellular drug/gene delivery. in addition, a high saturation magnetization of 93 emu/g fe was expected to facilitate magnetic targeting of gpei to brain tumor lesions. however, following intravenous administration ... | 2010 | 20494439 |
| multifunctional mesoporous composite microspheres with well-designed nanostructure: a highly integrated catalyst system. | the precise control of the size, morphology, surface chemistry, and assembly process of each component is important to construction of integrated functional nanocomposites. we report here the fabrication of multifunctional microspheres which possess a core of nonporous silica-protected magnetite particles, transition layer of active gold nanoparticles, and an outer shell of ordered mesoporous silica with perpendicularly aligned pore channels. the well-designed microspheres have high magnetizatio ... | 2010 | 20507122 |
| tinamous and moa flock together: mitochondrial genome sequence analysis reveals independent losses of flight among ratites. | ratites are large, flightless birds and include the ostrich, rheas, kiwi, emu, and cassowaries, along with extinct members, such as moa and elephant birds. previous phylogenetic analyses of complete mitochondrial genome sequences have reinforced the traditional belief that ratites are monophyletic and tinamous are their sister group. however, in these studies ratite monophyly was enforced in the analyses that modeled rate heterogeneity among variable sites. relaxing this topological constraint r ... | 2010 | 20525622 |
| preliminary investigation into the prevalence of mucormycosis in the platypus (ornithorhynchus anatinus) in three catchments in north-west tasmania. | to investigate the distribution and prevalence of mucormycosis in platypus (ornithorhynchus anatinus) from the inglis, emu and black-detention catchment areas in north-west tasmania. | 2010 | 20529030 |
| hs1 has a central role in the trafficking and homing of leukemic b cells. | the function of the intracellular protein hematopoietic cell-specific lyn substrate-1 (hs1) in b lymphocytes is poorly defined. to investigate its role in migration, trafficking, and homing of leukemic b lymphocytes we have used b cells from hs1(-/-) mice, the hs1-silenced human chronic lymphocytic leukemia (cll) mec1 cell line and primary leukemic b cells from patients with cll. we have used both in vitro and in vivo models and found that the lack of expression of hs1 causes several important f ... | 2010 | 20530793 |
| imaging and cell targeting characteristics of magnetic nanoparticles modified by a functionalizable zwitterionic polymer with adhesive 3,4-dihydroxyphenyl-l-alanine linkages. | multifunctional magnetic nanoparticles (mnps) modified by a zwitterionic polymer (pcbma-dopa(2)) containing one poly(carboxybetaine methacrylate) (pcbma) chain and two 3,4-dihydroxyphenyl-l-alanine (dopa) residue groups were developed. results showed that mnps modified by pcbma were not only stable in complex media, but also provided abundant functional groups for ligand immobilization. the pcbma-dopa(2) mnps had a hydrodynamic particle size of about 130 nm, a strong saturation magnetization of ... | 2010 | 20541254 |
| single-component molecular conductor [cu(tmdt)(2)] containing an antiferromagnetic heisenberg chain. | traditional molecular conductors are composed of more than two chemical species and are characterized by low-dimensional electronic band structures. by contrast, the single-component molecular metals [m(tmdt)(2)] (m = ni, pt, au; tmdt = trimethylenetetrathiafulvalenedithiolate) possess three-dimensional electronic structures that can be widely tuned by exchanging the central transition metal atom (m). in this study, the cu atom was used to realize a new magnetic single-component molecular conduc ... | 2010 | 20545349 |
| peglated magnetic polymeric liposome anchored with tat for delivery of drugs across the blood-spinal cord barrier. | due to the existence of the blood-spinal cord barrier (bscb), many therapeutic macromolecular agents, such as drugs, protein and gene, cannot pass through this barrier to reach the site of injury, all of which restricts the treatment of spinal cord injuries (sci). in this study, tat-conjugated peglated magnetic polymeric liposomes (tat-peg-mpls) formed from peglated amphiphilic octadecyl quaternized carboxymethyl chitosan (peg-oqcmc), cholesterol (chol), superparamagnetic nanoparticles, and tran ... | 2010 | 20553983 |
| chronic lymphocytic leukemia modeled in mouse by targeted mir-29 expression. | b-cell chronic lymphocytic leukemia (b-cll), the most common leukemia in the western world, occurs in two forms, aggressive (showing for the most part high zap-70 expression and unmutated igh v(h)) and indolent (showing low zap-70 expression and mutated igh v(h)). we found that mir-29a is up-regulated in indolent human b-cll as compared with aggressive b-cll and normal cd19(+) b cells. to study the role of mir-29 in b-cll, we generated emu-mir-29 transgenic mice overexpressing mir-29 in mouse b ... | 2010 | 20566844 |
| high-frequency, magnetic-field-responsive drug release from magnetic nanoparticle/organic hybrid based on hyperthermic effect. | magnetic nanoparticles (mnps) generate heat when a high-frequency magnetic field (hfmf) is applied to them. induction heat is useful not only for hyperthermia treatment but also as a driving force for drug-release. beta-cyclodextrin (cd) can act as drug container because of its inclusion properties. drugs incorporated in the cd can thus be released through the use of induction heating, or hyperthermic effects, by applying a hfmf. in this study, we have synthesized folic acid (fa) and cd-function ... | 2010 | 20568697 |
| reversion of epigenetically mediated bim silencing overcomes chemoresistance in burkitt lymphoma. | in burkitt lymphoma/leukemia (bl), achievement of complete remission with first-line chemotherapy remains a challenging issue, as most patients who respond remain disease-free, whereas those refractory have few options of being rescued with salvage therapies. the mechanisms underlying bl chemoresistance and how it can be circumvented remain undetermined. we previously reported the frequent inactivation of the proapoptotic bim gene in b-cell lymphomas. here we show that bim epigenetic silencing b ... | 2010 | 20570860 |
| the de-ubiquitinase uch-l1 is an oncogene that drives the development of lymphoma in vivo by deregulating phlpp1 and akt signaling. | de-ubiquitinating enzymes (dubs) can reverse the modifications catalyzed by ubiquitin ligases and as such are believed to be important regulators of a variety of cellular processes. several members of this protein family have been associated with human cancers; however, there is little evidence for a direct link between deregulated de-ubiquitination and neoplastic transformation. ubiquitin c-terminal hydrolase (uch)-l1 is a dub of unknown function that is overexpressed in several human cancers, ... | 2010 | 20574456 |
| magnetic and cytotoxicity properties of la(1-x)sr(x)mno(3) (0 </= x </= 0.5) nanoparticles prepared by a simple thermal hydro-decomposition. | this study reports the magnetic and cytotoxicity properties of magnetic nanoparticles of la(1-x)sr(x)mno(3) (lsmo) with x = 0, 0.1, 0.2, 0.3, 0.4, and 0.5 by a simple thermal decomposition method by using acetate salts of la, sr, and mn as starting materials in aqueous solution. to obtain the lsmo nanoparticles, thermal decomposition of the precursor was carried out at the temperatures of 600, 700, 800, and 900 degrees c for 6 h. the synthesized lsmo nanoparticles were characterized by xrd, ft-i ... | 2009 | 20596291 |
| preparation and characterization of silica-coated magnetic-fluorescent bifunctional microspheres. | bifunctional magnetic-fluorescent composite nanoparticles (mpqds) with fe(3)o(4) mps and mn:zns/zns core-shell quantum dots (qds) encapsulated in silica spheres were synthesized through reverse microemulsion method and characterized by x-ray powder diffraction, scanning electron microscopy, transmission electron microscopy, vibration sample magnetometer, and photoluminescence (pl) spectra. our strategy could offer the following features: (1) the formation of mn:zns/zns core/shell qds resulted in ... | 2009 | 20596403 |
| magnesium ferrite (mgfe(2)o(4)) nanostructures fabricated by electrospinning. | magnesium ferrite (mgfe(2)o(4)) nanostructures were successfully fabricated by electrospinning method. x-ray diffraction, ft-ir, scanning electron microscopy, and transmission electron microscopy revealed that calcination of the as-spun mgfe(2)o(4)/poly(vinyl pyrrolidone) (pvp) composite nanofibers at 500-800 degrees c in air for 2 h resulted in well-developed spinel mgfe(2)o(4) nanostuctures. the crystal structure and morphology of the nanofibers were influenced by the calcination temperature. ... | 2008 | 20596441 |
| bi-functional silica nanoparticles doped with iron oxide and cdte prepared by a facile method. | cadmium telluride (cdte) and iron oxide nanoparticles doped silica nanospheres were prepared by a multistep method. iron oxide nanoparticles were first coated with silica and then modified with amino group. thereafter, cdte nanoparticles were assembled on the particle surfaces by their strong interaction with amino group. finally, an outer silica shell was deposited. the final products were characterized by x-ray powder diffraction, transmission electron microscopy, vibration sample magnetometer ... | 2009 | 20596493 |
| use of thiafentanil-medetomidine for the induction of anesthesia in emus (dromaius novaehollandiae) within a wild animal park. | fifteen adult emu (dromaius novaehollandiae) anesthetic events were successfully undertaken with the use of thiafentanil oxalate (a3080) 0.175 mg/kg i.m. (sd 0.026) and medetomidine 0.092 mg/kg i.m. (sd 0.009) via remote injection. following induction, the birds were transported to the clinic, where a venous blood gas sample was taken for analysis, which indicated a respiratory acidosis, with a mean arterial pco2 of 54.46 mmhg (sd 9.31) and venous ph of 7.135 (sd 0.11), most likely due to modera ... | 2010 | 20597214 |
| synthesis and characteristic of the fe3o4@sio2@eu(dbm)3.2h2o/sio2 luminomagnetic microspheres with core-shell structure. | the core-shell structured luminomagnetic microsphere composed of a fe(3)o(4) magnetic core and a continuous sio(2) nanoshell doped with eu(dbm)(3).2h(2)o fluorescent molecules was fabricated by a modified stöber method combined with a layer-by-layer assembly technique. x-ray diffraction (xrd), fourier transform infrared spectroscopy (ftir), field emission scanning electron microscopy (fe-sem), transmission electron microscopy (tem), confocal microscopy, photoluminescence (pl), and superconductin ... | 2010 | 20602919 |