Publications

TitleAbstractYear
Filter
PMID(sorted ascending)
Filter
[fluorescence-microscopical demonstration of biogenic monoamines in the epiphysis cerebri of rana esculenta and rana pipiens]. 19705485027
regeneration of rhodopsin in the isolated retina of the frog (rana esculenta). 19705488271
the metabolic rate of the intact frog (rana esculenta l.) and its isolated tissues at different ambient temperatures. 19705491273
morpho-functional study of hypothalamic neurosecretion. iv. the effect of osmotic stress on the preoptico-neurohypophysial system of rana esculenta, rana temporaria, and xenopus laevis. 19705493990
morpho-functional study of hypothalamic neurosecretion. vi. the effect of locally administered x-irradiation in rana temporaria and rana esculenta. 19705493992
[electron microscopic study of the neurohypophysis of rana esculenta l]. 19705495355
[identification and localization of the aminergic fibres in the median eminence of the frog (rana esculenta l.) by electron microscopic autoradiography]. 19705495356
changes in the cytology of the pars distalis of pituitary of green frog, rana esculenta, under laboratory confinement. 19705500431
[proteins of the blood plasma and lymph in the frog (rana esculenta). ii. immunoelectrophoretic studies]. 19705512314
pigmentary potentiality of the truncal medullary plate of rana esculenta. 19705518033
[transport of chlorine in the small intestine of rana esculenta]. 19705519801
cytological changes in the pars distalis of pituitary of the green frog, rana esculenta l., during the reproductive cycle. 19705530269
cytological and functional segmentation of the proximal tubule in the mesonephros of rana esculenta (l.). 19715564113
[effect of colcemid (n-desacetyl-n-methyl-colchicine) on the spiralization of the mitotic chromosomes of rana esculenta l]. 20155600390
[the millimolar extinction coefficient of cyanohematoglobin in rana esculenta and axolotl mexicanum]. 19675618687
[activity of lactic acid dehydrogenase (ldh) and of glucose-6-phosphate dehydrogenase (g-6-pdh) in the epithelium of the gallbladder of the frog (rana esculenta)]. 19675629599
electron-microscopic investigation of the thymus of adult frog (rana esculenta). 19685692605
[on lymph proteins of rana esculenta]. 19685709545
[further studies on the regeneration of the spinal cord in rana esculenta l. and rana temporaria l]. 19685715912
the hemoglobins of ambystoma tigrinum green and of rana esculenta l. a comparative study on their primary structure. 19685727746
[the effect of the exclusion of the horizontal semicircular canals on the reaction to tilting in the frog (rana esculenta l]. 19685732651
[influence of elimination of the utriculi on reactions due to stimulation of the horizontal semicircular canals in the frog (rana esculenta l.)]. 19685734502
[regarding the frequency of the inversions in graphs presenting the phenomenon of highly variable mechanical responses. experiments carried out on the striate muscle of rana esculenta by repeated stimulation at low frequency and at constant submaximal intensity]. 20155736770
[special aspects of intersexuality in rana esculenta]. 19685740925
[statistical study on the subject of determination of chorionic hormones using the moroccan rana esculenta]. 20035758410
[electron microscopical investigation on the reaction of the pituicytes after stalk section in rana esculenta]. 19695784538
responses of rana temporaria and rana esculenta to prolonged exposure to a saline environment. 19695786829
investigations of lymph proteins of amphibian, rana esculenta, by zone electrophoresis on several supporting media. 19695786832
purification of p-hydroxyphenylpyruvate hydroxylase and its natural inhibitor from liver of the frog, rana esculenta. 19695791859
[adaptation of rana esculenta to various environments. a special study of renal excretion of water and electrolytes during changes in environment]. 19695795818
the effect of temperature elevation and feeding on the pancreas of rana esculenta in late winter. a biochemical and ultrastructural study. 19695807447
[the nycthemeral rhythm of oxygen consumption in frogs (rana esculenta)]. 19695807998
catabolism of allantoate and ureidoglycolate in rana esculenta. 19695809773
[regeneration of the transsected spinal cord in the rana esculenta]. 19655825938
the ultrastructure of gliosomes in the brains of amphibia.small fragments of superficial neuropil and fragments of deeper layers from various regions of the brains of xenopus laevis daud. and rana esculenta l. were fixed in buffered osmium tetroxide, embedded in vestopal w or methacrylate, and studied with the electron microscope. the glial fibers and their meningeal end-feet contain numerous large mitochondrion-like dense bodies for which the term "gliosome" has been adopted. gliosomes have a specific and constant structure characterized by the presen ...19655865926
[electron microscopic studies on the nerve tracts of the pineal complex of rana esculenta l]. 19655869603
[the osmotic behavior of the isolated skin of rana esculenta]. 19655876890
[the net inflow of sodium ion and the total outflow of chlorine ion in isolated rana esculenta skin under the action of triamterene]. 19635877327
[localization of a substance with pterin nucleus in the skin of rana esculenta l]. 19645878052
[effects of different doses of post-pituitary hormone on active transport of nacl across isolated skin of rana esculenta]. 19645878122
[comparison of the effects of postpituitary hormone on the active transport of nacl and on the passive permeation of some electrolytes into the isolated skin of rana esculenta]. 19645878123
[effects of substitution of sodium chloride of the perfusion solution on active transport of sodium by the isolated skin of rana esculenta]. 19655878195
[analysis of the effects of a thiazide diuretic (benzhydroflumethiazide) on hydraulic permeability of isolated skin of rana esculenta]. 19655878482
[the hemoglobin of amphibia. 3. characterization of the hemoglobin of rana esculenta: chemico-physical properties and amino acid composition]. 19655889622
[details on the possiblity of destroying the germinal plasma of the egg of rana esculenta with ultraviolet rays]. 19645896203
[the gametokinetic reaction in male amphibia. i. weight changes of the testicles of rana esculenta l. in vivo caused by injection of human chorionic gonadotropin]. 19655896421
[the gametokinetic reaction in male amphibia. ii. weight changes of the testicles of rana esculenta l. in vitro caused by human chorionic gonadotropin]. 19655896422
[the gemetokinetic reaction in male amphibia. 3. weight changes of the testicles of rana esculenta l. in vitro caused by hypotonic solutions]. 19655896423
effect of inhibitors on the histochemical reaction of alkaline alpha-naphthyl- and naphthol-as-phosphomonoesterase in the kidney of edible-frog (rana esculenta l.). 19665905593
electron microscopic observations on vacuolated neurons in starved rana esculenta. 19665935370
[inhibitory action of rana esculenta cerebral poltiglia on the development of the cerebral ganglia of planaria]. 19665945191
[hormonal regulation of alkaline and acid phenylphosphatases, acid proteinase and alanylglycine dipeptidase of the oviduct in rana esculenta. 2. action of progesterone]. 20155959300
[hormonal regulation of alkaline and acid phenylphosphatases, acid proteinase and alanylglycine dipeptidase of the oviduct in rana esculenta. 3. action of progesterone and of 17-beta-estradiol in various combinations]. 20155959301
[effects of some diuretics on the hydraulic permeability of the isolated skin of rana esculenta]. 19665969316
[analysis of the effects induced by furosemide and hgcl 2 on hydraulic permeability of the isolated skin of rana esculenta]. 19665972384
[on the development of the spinal cord of rana esculenta after metamorphosis]. 19665982859
further observations on gomori-positive material containing cells in the telencephalon of rana esculenta. 19665986016
[on the autonomous nature of the seasonal mitotic activity of the crystalline lens epithelium in rana esculenta]. 19665986469
[hemoglobin in amphibia. iv. chromatographic and electrophoretic pattern of oxyhemoglobin in rana esculenta l]. 19666004977
[on melanokinesis of internal ear pigmented cells in rana esculenta and cava cobaya. hormonal and ultrastructural studies]. 19666012355
cytological effect of the gastropancreatic reflex on the acinar cells of the pancreas in rana esculenta. 19676030729
the hemoglobin of amphibia. v. the amino-terminal residues and the carboxyl-terminal sequences of the hemoglobin of rana esculenta l. 19676047654
effect of estradiol-17-beta on the distribution of 3-beta-hydroxysteroid dehydrogenase in the testes of rana esculenta and lacerta sicula. 19676050510
[on the color change in rana esculenta following epiphysectomy]. 19676057032
[on the ultrastructure of the autonomic innervation in the neuromuscular apparatus of some outer eye muscles of the rana esculenta]. 19676080693
the distribution of substance p in the habenulo-interpeduncular system of the frog shown by an immunohistochemical method.the distribution of substance p(sp)-like immunoreactivity was studied in the habenulo-interpeduncular (hab-itp) complex of the frog rana esculenta by means of the immunohistochemical peroxidase-antiperoxidase (pap) method. the hab of the frog were subdivided into dorsal and ventral nuclei, corresponding to the medial and lateral hab of mammals respectively. in addition, the dorsal hab of the frog were morphologically asymmetric, since only the left has a lateral and a medial subnucleus. sp-like ...19846084986
solubilization and characterization of opioid binding sites from frog (rana esculenta) brain.active opioid receptors were solubilized from frog (rana esculenta) brain membrane fractions by the use of 1% digitonin. it was found by kinetic as well as by equilibrium measurements that both the membrane and the solubilized fractions contain two binding sites. for the membrane preparations, kd values were 0.9 and 3.6 nm, and bmax values were 293 and 734 fmol/mg protein. for the solubilized preparations, kd values were 0.4 and 2.6 nm, an bmax values were 35 and 266 fmol/mg protein. the stereos ...19846088699
natural interspecies transfer of mitochondrial dna in amphibians.mtdnas of two central european water frog species, rana ridibunda and rana lessonae, were examined by electrophoresis of restriction enzyme fragments. two types of mtdna occur in r. ridibunda. one shares with mtdna of r. lessonae 25.8% of 132 fragments generated by 19 enzymes, corresponding to a nucleotide sequence divergence of 8.1%; the other has diverged from r. lessonae mtdna by only 0.3%. this latter type is a variant r. lessonae mtdna that has been transferred into r. ridibunda; the introg ...19846091109
maturation involves suppression of voltage-gated currents in the frog oocyte.voltage- and time-dependent currents having slow kinetics have been studied in plasma membranes of immature oocytes of the european frog, rana esculenta. ik, corresponding to an outward flow of k+, is activated at potentials more positive than about -40 mv, and subserves outward rectification; iir, corresponding to an outward flow of cl-, is activated at potentials more negative than about -80 mv and subserves inward rectification. such currents can act as negative feedback mechanisms in the con ...19846094599
mechanism of hydrogen ion transport in the diluting segment of frog kidney.transepithelial h+ transport was studied in diluting segments of the isolated-perfused kidney of rana esculenta. the experiments were performed in controls as well as in k+-adapted and na+-adapted animals (exposed to 50 mmol/l kcl or nacl, resp. for at least 3 days). conventional and single-barreled, liquid ion-exchanger h+-sensitive microelectrodes were applied in the tubule lumen to evaluate transepithelial h+ net flux (jhte) as well as limiting transepithelial electrical and h+ electrochemica ...19846097868
distinctly different rates of benzocaine action on sodium channels of ranvier nodes kept open by chloramine-t and veratridine.single myelinated nerve fibres of the frog, rana esculenta, were voltage clamped in a fast-exchange chamber in the presence of 10 mm tea to block potassium channels. after treatment with 0.6 mm chloramine-t for 1-4 min a sizeable ina component persisted even during a 14-s depolarizing impulse. changing the perfusate to ringer solution + 1 mm benzocaine resulted in a fast reduction (half time ca. 0.06 s) of the persistent ina, comparable to the rate of block of peak ina during a series of short i ...19846097874
modification of sodium inactivation in myelinated nerve by anemonia toxin ii and iodate. analysis of current fluctuations and current relaxations.(1) na+ currents and na+ current fluctuations were measured in single myelinated nerve fibres of rana esculenta under voltage-clamp conditions. the process of na+ inactivation was modified by external treatment with 7 microm anemonia toxin ii or by internal application of 20 or 40 mm io3(-). (2) at depolarization of 24 and 32 mv the spectral density of na+ current fluctuations could be described as the sum of two contributions, sh(f) and sm(f), representing the spectrum from fluctuations of the ...19806105881
tyrosine aminotransferase activity of frog (rana esculenta) liver.1. the presence of tyrosine aminotransferase is reported both in particulate and soluble fractions of frog liver. 2. the activity of the soluble enzyme of frog liver was investigated with regard to its dose and time dependence, its substrate specificity and concentration dependence, its thermal sensitivity as well as ph and temperature dependence. 3. it appears that the properties of the soluble tyrosine aminotransferase of frog liver are in close agreement with those reported for the mammalian ...19826121662
modification of sodium channels in myelinated nerve by anemonia sulcata toxin ii.1. single myelinated nerve fibres of the frog, rana esculenta, were investigated predominantly in voltage clamp experiments. 2. sodium current (ina) inactivation was measured in the presence of 10 mm tea to suppress ik. inactivation was diphasic but complete in toxin-free solution; it was delayed and became incomplete in anemonia sulcata toxin ii (atx ii) leading to persistent ina flow even during long depolarizations. the effects were reversible. activation was not affected. 3. the persistent i ...19816125592
rate of action of anemonia sulcata toxin ii on sodium channels in myelinated nerve fibres.1. the effect of anemonia sulcata toxin ii (atx ii) on single myelinated nerve fibres of the frog, rana esculenta, was investigated. 2. atx ii promptly and reversibly increased the duration of action potentials; on applying 9.5 micro m the time, t0.5, to reach half of the final effect was 2.6 s. in the presence of 10 mm tetraethylammonium the duration was very sensitive to atx ii and as little as 10 nm could be detected. 3. the underlying mechanism was a diphasic incomplete inactivation of sodiu ...19826128716
tyrosine aminotransferase activity of frog (rana esculenta) liver--ii. comparative aspects of intracellular distribution.1. a subcellular fractionation procedure for frog liver is reported and validated by the distribution pattern of several marker enzymes, also in comparison with rat liver. 2. the subcellular distribution of tyrosine aminotransferase was investigated in frog liver as compared to rat liver: a different distribution of the enzyme was observed, being the activity mostly recovered in mitochondrial and cytosolic compartments. 3. results indicate that mitochondrial tyrosine aminotransferase of both fro ...19826129941
haematological studies on the prewintering and wintering frog, rana esculenta.1. a study of the haematology of the frog rana esculenta including erythrocyte count (rbc), haemoglobin content (hb), haematocrit (hct), mean cell volume (mcv), mean corpuscular haemoglobin (mch), mean corpuscular haemoglobin concentration (mchc) and erythrocyte size as a function of prewinter and winter was made. 2. the rbc count and hb were significantly higher in contrast to mcv and mch values during prewinter in both sexes. 3. the surface area to volume ratio was higher in prewinter whereas ...19836131773
unusual features of the ca2+-atpase activity of myosin from fast skeletal muscle of the frog: effect of actin and sh1 thiol group modification.the k+-atpase and actin-activated mg2+-atpase activity of myosin from fast skeletal muscle of the frog, rana esculenta or rana temporaria, are comparable to the respective activities of rabbit fast skeletal muscle. on the other hand, the ca2+-atpase activity of the same preparations of frog myosin is 6-7-fold lower than that of myosin from rabbit muscle. various control experiments indicate that the small extent of ca2+ stimulation is an intrinsic property of frog muscle myosin. unlike myosin fr ...19836134751
serosal and mucosal facilitated transport of urea in urinary bladder of of bufo bufo: evidence for an alleged water uptake.in bufo bufo urinary bladder an urea facilitated transport has been localised on the luminal membrane. the transport fulfils the criteria for such a mechanism, i.e. is saturable and is inhibited by phloretin, a specific inhibitor for urea transport. similarly to that of bufo marinus and rana esculenta the luminal membrane of bufo bufo urinary bladder shows an adh stimulated facilitated transport. experiments wtih amphotericin b, serosal phloretin (with and without adh), have demonstrated the pre ...19836135534
changes in acetylcholine concentration, miniature end-plate potentials and synaptic vesicles in frog neuromuscular preparations during lanthanum treatment.ach content and synaptic ultrastructure were compared in neuromuscular preparations (sartorius muscle of rana esculenta) incubated in control saline and in saline containing 1 mm lacl3. ach concentrations remained constant for 6 hr in control preparations. la3+ caused a 38% depletion of ach within the first 30 min with subsequent recovery to 120% of control values within 3-4 hr. recovery was prevented by hemicholinium-3. at 23 degrees c la3+ caused complete loss of synaptic vesicles: no depletio ...19836138197
combined action of intraaxonal iodate and external sea anemone toxin atx ii on sodium channel inactivation of frog nerve fibres.voltage clamp experiments were done on single myelinated nerve fibres of the frog, rana esculenta, with 10 mm tea+ in the external solutions to block potassium channels. iodate (20, 40 or 100 mm kio3) was applied to the axoplasmic side of the nodal membrane by diffusion from a cut internode. the effect of 20 mm started within a few minutes and reached a stationary value after ca. 20 min which was maintained for another 15 min. the size of the effect was independent of the iodate concentrations t ...19836138749
studies on the effect of the pyrethroid insecticide decamethrin on ionic transport through the in vitro skin of rana esculenta.the effect of the insecticide decamethrin on ionic transport through the isolated skin of rana esculenta was studied; the skins were bathed with 1-2 meq na2so4 or choline-cl solutions (exterior), and with ringer normal (interior). under open circuit (oc) conditions, mucosal decamethrin (10(-6) m), did not provoke changes in na+ fluxes. at 10(-5) m there was a slight inhibition of the jona+ after 30 min. the cl- fluxes did not change. with longer treatments (60-90 min, oc, 10(-5) m) the jnna+ was ...19836139244
tyrosine aminotransferase activity of frog (rana esculenta) liver. iii. a circannual study.a circannual study of tyrosine aminotransferase and other metabolic enzymes in frog liver is reported. the subcellular distribution of all enzymatic activities under investigation was also studied. results show significant oscillations of all enzymatic activities throughout the year; in particular tyrosine aminotransferase has a marked summer maximum. the subcellular distribution of tyrosine aminotransferase shows significant variations: the soluble activity of the enzyme presents a bimodal circ ...19846150807
neuroanatomical identification of the frog habenular connections using peroxidase (hrp).a study of the habenular nuclei connections by means of horseradish peroxidase (hrp) has never been carried out in amphibia. in the present paper we have investigated the afferent projections of the left and right habenular nuclei of the frog rana esculenta using this technique. cells, labelled by hrp, were either in a golgi-like pattern or in a granular pattern. it appears that the habenular nuclei on the two sides of the epithalamus do not show different connections even though they are morpho ...19806154592
origin of centrifugal fibers to the labyrinth in the frog (rana esculenta). a study with the fluorescent retrograde neuronal tracer 'fast blue'.after injecting a solution of a fluorescent retrograde neuronal tracer (fast blue, diamidino compound 253/50) into the perilymphatic space of the frog labyrinth (rana esculenta), labeled cells were found in the ventral and dorsal nuclei of the viiith nerve and in the nucleus reticularis medius. we consider these labeled cells to be the origin of the efferent innervation of the frog labyrinth. no evidence was found for the existence of a direct cerebello-labyrinthine connection.19816167319
active urea transport through isolated skins of frog and toad.urea influxes (ji) and effluxes (je) were studied across the isolated skins of rana esculenta, bufo bufo, and b. viridis. two symmetrical pieces of the same skin, bathed in ringer + 2 mm urea, were used for the two fluxes. in r. esculenta the urea fluxes are passive when the animals are kept in running water but become active after dehydration in air or preadaptation in saline solutions. the ratio ji/je can vary between 3 and 27 and the ji between 2 and 22 nmol . h-1 . cm-2 according to preadapt ...19816169283
seasonal fluctuations of pancreatic activities and cyclic nucleotide levels in the frog rana esculenta.1. seasonal influence on pancreatic activity has been determined in the frog rana esculenta. 2. protein content, amylase activity and cyclic nucleotide levels, show significant changes throughout the year, being higher in the active period (spring, summer), with respect to a constant pancreas weight. 3. a significant correlation between protein content and cyclic amp levels has been observed. 4. results suggest that feeding habits exert a control on the pancreatic activity even if stimuli other ...19826175476
[gramicidin a-induced membrane conductance of isolated muscle fiber].the conductance of single fibres from m. ileofibularis of rana esculenta was studied in isotonic k2so4 solution under constant--current conditions using the double sucrose gap method. the antibiotic gramicidin a effects a drastic increase of membrane conductance. variation of the gramicidin-induced conductance with gramicidin concentration in the bathing solution (10(-8)-5,5 . 10(-7) m) was investigated. gramicidin-induced conductance was proportional to the square of gramicidin concentration in ...20146178439
[effect of thallium ions on gramicidin-induced conductance of muscle fiber membranes].conductance of single fibres from m. ileofibularis of rana esculenta was studied in isotonic k2so4 solution under constant current conditions using the double sucrose gap method. it was found that tl+ (at concentrations 5, 10, and 20 mm) blocked k+ currents in the gramicidin channel. the decrease of k+ conductance caused by tl+ was associated with the changes of the membrane potential. both the decrease of k+ conductance and value of permeability ratio (ptl/pk) found from the membrane potential ...20146197098
methoxyindole synthesis in the retina of the frog (rana esculenta) during a diurnal period.in the present study, the synthesis of methoxyindoles in the neural part and in the pigment epithelial layer of the retina of the frog eye was investigated on the basis of naturally occurring substrate at regular intervals during a 24 hour period. melatonin, 5-methoxytryptophol and 5-methoxyindole acetic acid were synthesized by the neural part of the retina only, while 5-methoxytryptamine and 5-methoxytryptophan were produced by both, the neural part of the retina and the pigment epithelium. th ...19836198459
the extracranial portion of the pineal complex of the frog (frontal organ) is connected to the pineal, the hypothalamus, the brain stem and the retina.the central connections of the frontal organ of the frog rana esculenta were studied by means of the cobalt-filling technique using the cobaltic lysine complex. the results showed that the frontal organ has surprisingly more extended connections than those demonstrated after the application of other techniques. in fact, we found that it is connected to the pineal, the hypothalamus, the brain stem and the retina. these connections, which neuroanatomically have not been reported before, suggest th ...19836201381
immunoreactive opsin in the pineal organ of reptiles and birds.the presence of opsin was investigated with light microscopic immunocytochemistry in pinealocytes of reptiles and birds (emys orbicularis, pseudemys scripta elegans, lacerta agilis et viridis, gallus domesticus, columba livia, melopsittacus undulatus, serinus canaria, taeniopyga punctate). the outer segments of pinealocytes selectively bound antiopsin antibody as revealed by indirect immunocytochemical techniques, indicating the occurrence of a rhodopsin-like photopigment in these structures. th ...19826213109
cerebrospinal fluid-contacting neurons, sensory pinealocytes and landolt's clubs of the retina as revealed by means of an electron-microscopic immunoreaction against opsin.opsin-immunoreactive sites of hypothalamic cerebrospinal fluid (csf)-contacting neurons, pinealocytes and retinal cells were studied in various vertebrates (carassius auratus, phoxinus phoxinus, triturus cristatus, bombina bombina, rana esculenta) by means of postembedding immuno-electron microscopy with the use of the protein a-gold labeling method. the retina of the rat served as a general reference tissue for the quality of the immunocytochemical reaction. a strong opsin immunoreaction (rat-a ...19836226359
ultracytochemical localization of ca++-atpase activity in the paraphyseal epithelial cells of the frog, rana esculenta.ca++-atpase activity was studied ultracytochemically (cf. ando et al. 1981) in the paraphysis cerebri of the frog. an intense reaction was demonstrated on the plasmalemma of the microvilli at the apical pole of paraphyseal cells; in contrast, the basolateral plasmalemma showed only a slight staining. in addition, mitochondria, gap junctions, cilia, and cytoplasmic elements (e.g., microfilaments) displayed ca++-atpase activity. variation of the ca++-concentration in the incubation medium from 0.1 ...19846230154
re-investigation of the role of the accessory optic system and pretectum in the horizontal optokinetic head nystagmus of the frog. lesion experiments.the effects of various lesions in the accessory optic system and pretectal area were studied on the horizontal optokinetic head nystagmus (okn) in the frog rana esculenta. for histological control the cobalt-filling technique and haematoxylineosin staining were used. isolated complete transection of the basal optic root caused only a slight reduction in the frequency of the okn. transection of the marginal optic tract on one side reduced the frequency as if one eye had been removed. electrolytic ...19836237533
intra-individual length heterogeneity of rana esculenta mitochondrial dna.mitochondrial dna extracted from rana esculenta oocytes appears heterogeneous in size. the length of these molecules varies continuously from 18,700 bp to 19,700 bp. each animal is heteroplasmic and can be characterized by the range of the variation (400-700 bp) and the extreme sizes of the various molecules it carries. the variable region of the genome has been localized between the coding region and the replication origin area.19846241832
phenobarbital induces slow recovery from sodium inactivation at the nodal membrane.voltage-clamp experiments were performed on single myelinated nerve fibres of rana esculenta at 20 degrees c in ringer's solution and in solutions containing phenobarbital-sodium ([pb] less than or equal to 5 mm). the reduction of the sodium current under phenobarbital could be explained by an increase in the resting sodium inactivation; h infinity (e) was shifted towards more negative membrane potentials. the recovery from sodium inactivation proceeded with two time constants. the fast process ...19806245694
carticaine: action of the local anesthetic on myelinated nerve fibres.unlike other clinically used local anesthetics, carticaine contains a thiophene ring. current voltage relations of peak sodium current ina and steady state potassium current ik were measured in voltage clamp experiments on the node of ranvier of rana esculenta. the dependence of the maximum sodium conductance on external concnetration of carticaine is described by an apparent dissociation constant kna = 0.065 mm at ph = 7.3. an apparent dissociation constant kk = 0.147 mm at ph = 7.3 was calcula ...19806245896
relations between the inactivation of sodium channels and the immobilization of gating charge in frog myelinated nerve.1. single, voltage-clamped nerve fibres of rana esculenta were stimulated with ;p/2' pulse patterns for measuring na and gating currents at 13 degrees c.2. gating currents during test pulses to - 122 or + 10 mv were measured after 45 msec conditioning steps to voltages between - 122 and - 18 mv. as the conditioning voltage was made more positive than - 80 mv, the movable gating charge diminished along a sigmoid curve, approaching a value of nearly one third of the maximum charge. on the other ha ...19806247484
interaction of lidocaine and benzocaine in blocking sodium channels.1. single myelinated nerve fibres of the frog, rana esculenta, were investigated in voltage and current clamp experiments at ph 7.2 2. measured with infrequent test pulses, 0.123 mm lidocaine reduced ina to 54%, 0.25 mm benzocaine to 40% and the mixture 0.125 mm lidocaine +/- 0.25 mm benzocaine to 31% of the control. when hyperpolarizing prepulses (v = -40 mv for 15 ms) preceded the test pulses the respective reductions were to 58%, 74% and 55% i.e. adding benzocaine to lidocaine had little addi ...19806251426
Displaying items 601 - 700 of 1616