Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| intrathecal synthesis of ige in children with eosinophilic meningoencephalitis caused by angiostrongylus cantonensis. | abstract: | 2008 | 19032790 |
| [study on the epidemiological characteristics and natural infectious focus of angiostrongylus cantonensis in shenzhen area of zhujiang delta in china]. | to delimit the natural infectious focus, including the distribution of wildlife, species, ecology of intermediate hosts and final host of angiostrongylus cantonensis, as well as the routes of transmission and epidemiological characteristics and wildlife of human angiostrongylus cantonensis, based on human diverging cases identified in shenzhen, southern area of china. | 2008 | 19040040 |
| enzootic angiostrongyliasis in shenzhen, china. | 2008 | 19046534 | |
| optic neuritis caused by intraocular angiostrongyliasis. | a 21-year-old thai man first presented with eosinophilic meningitis. one week later he developed visual impairment of the left eye with a visual acuity of 20/600. he had a marcus gunn pupil, constricted visual field, prolongation of visual evoked potential and the presence of inflammatory cells in the vitreous cavity of the affected eye. on funduscopic examination there was disc swelling with hyperemia of the left eye. these ocular findings are compatible with optic neuritis. the causative agent ... | 2008 | 19062688 |
| abdominal angiostrongyliasis: report of two cases with different clinical presentations. | abdominal angiostrongyliasis is a sporadic infectious disease caused by the nematode angiostrongylus costaricensis. it usually presents as acute abdomen, secondary to mesenteric ischemia, and pronounced eosinophilia. in some cases its course is insidious and transient, and the diagnosis is suspicious. the disease is confirmed by the detection of a. costaricensis elements in surgical specimen. the treatment is supportive, with avoidance of antihelminthic administration due to a possible erratic m ... | 2008 | 19082375 |
| immunological diagnosis of human angiostrongyliasis due to angiostrongylus cantonensis (nematoda: angiostrongylidae). | angiostrongylus cantonensis-associated eosinophilic meningitis in humans has been commonly reported worldwide. however parasitologically confirmed cases are not common, as the parasite has been recovered only infrequently from the cerebrospinal fluid of patients. the potential value of immunodiagnosis is therefore self-evident. immunological tests can also help in the differential diagnosis of parasitic (particularly helminths) infections that cause eosinophilic meningitis. this paper summarizes ... | 2009 | 19117782 |
| eosinophilic meningitis due to angiostrongylus and gnathostoma species. | eosinophilic meningitis can be the result of noninfectious causes and infectious agents. among the infectious agents, angiostrongylus cantonensis and gnathostoma spinigerum are the most common. although angiostrongyliasis and gnathostomiasis are not common in the united states, international travel and immigration make these diseases clinically relevant. both a. cantonensis and g. spinigerum infection can present as severe cns compromise. diagnoses of both infections can be challenging and are o ... | 2009 | 19123863 |
| [pathological change in the brain of mice infected with angiostrongylus cantonensis]. | to observe the pathological change in the brain of angiostrongylus cantonensis-infected mouse. | 2008 | 19157298 |
| [epidemiological investigation of angiostrongylus cantonensis in jiangmen of guangdong province]. | to make an epidemiological survey on angiostrongylus cantonensis in jiangmen city of guangdong province. | 2008 | 19157302 |
| [morphology of iii stage larvae of angiostrongylus cantonensis in pomacea canaliculata]. | to observe the morphologic characteristics of iii stage larvae of angiostrongylus cantonensis from pomacea canaliculata. | 2008 | 19160967 |
| angiostrongylus cantonensis: morphological and behavioral investigation within the freshwater snail pomacea canaliculata. | an infection with angiostrongylus cantonensis, the main causative agent for human eosinophilic encephalitis, can be acquired through the consumption of the freshwater snail pomacea canaliculata. this snail also provides a suitable model to study the developmental morphology and behavior of a. cantonensis larvae, facilitated by the snail's distinct lung structure. we used microanatomy for studying the natural appearance and behavior of a. cantonensis larvae while developing within p. canaliculata ... | 2009 | 19172296 |
| invasive snails and an emerging infectious disease: results from the first national survey on angiostrongylus cantonensis in china. | eosinophilic meningitis (angiostrongyliasis) caused by angiostrongylus cantonensis is emerging in mainland china. however, the distribution of a. cantonensis and its intermediate host snails, and the role of two invasive snail species in the emergence of angiostrongyliasis, are not well understood. | 2009 | 19190771 |
| surveillance of endoparasitic infections and the first report of physaloptera sp. and sarcocystis spp. in farm rodents and shrews in central taiwan. | a total of 95 rodents and shrews including 82 rattus norvegicus, 7 rattus rattus, and 6 suncus murinus were trapped from different localities of taichung, taiwan. the overall prevalence of parasites was 93.7%. the infection rates for r. norvegicus, r. rattus, and s. murinus were 93.9%, 85.7%, and 100%, respectively. the rats were infected with four cestodes, taenia taeniaeformis (48.4%), hymenolepis diminuta (38.9%), hymenolepis nana (5.3%), and raillietina celebensis (45.3%); ten nematodes, ang ... | 2009 | 19194075 |
| thai koi-hoi snail dish and angiostrongyliasis due to angiostrongylus cantonensis: effects of food flavoring and alcoholic drink on the third-stage larvae in infected snail meat. | human infection with the rat lungworm angiostrongylus cantonensis (parastrongylus cantonensis) in thailand, especially in the northeastern region, is associated with the habit of eating koi-hoi, which contains raw snail meat. infection results from the snails being carriers of the larval parasite. the present study was conducted to assess the effect of food flavorings in koi-hoi, alcohol, and exposure time of the two variable on the infective larvae of a. cantonensis. infected biomphalaria glabr ... | 2009 | 19272010 |
| helminthic eosinophilic meningitis: emerging zoonotic diseases in the south. | today most emerging infectious diseases, such as west nile virus and severe acute respiratory syndrome (sars), arise in the natural environment as zoonoses and are often imported into the united states (us). the most common helminthic infections that can cause eosinophilic meningitis (eom) in the us, neuroangiostrongyliasis and baylisascariasis, share many of the characteristics of emerging infectious diseases. neuroangiostrongyliasis, a rodent zoonosis caused by the rat lungworm, angiostrongylu ... | 2008 | 19283982 |
| existence of angiostrongylus cantonensis in rats (rattus norvegicus) in grenada, west indies. | the zoonotic rat lung worm, angiostrongylus cantonensis is endemic to asia, north america, africa and australia. the parasite is expanding geographically and has recently been recorded in some of the greater antilles in the northern part of the caribbean. in this study a. cantonensis is reported for the first time in the lesser antilles in one of the southernmost islands, grenada. between september 2005 and september 2006, 192 rats (rattus norvegicus) were trapped throughout the island. the rats ... | 2009 | 19304395 |
| [proposed chinese name of pomacea canaliculata]. | the way to translate species name of pomacea canaliculata into chinese has been of confusion for a long time. we collected the relevant references on investigations of snail, species similar to pomacea canaliculata and made comparison on the characteristics of those species which serve as intermediate snail host of angiostrongylus cantonensis. it is proposed the genus name of pomacea is translated as [chinese characters: see text], and species name pomacea canaliculata be [chinese characters: se ... | 2009 | 19459504 |
| dynamic changes of hepatocyte growth factor in eosinophilic meningitis caused by angiostrongylus cantonensis infection. | hepatocyte growth factor (hgf) is a member of the angiogenic growth factor family, which exerts a variety of effects on epithelial, endothelial, and neuronal cells by binding to the c-met receptor tyrosine kinase. it was reported that hgf attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier (bbb) and decreases in expression of tight junction proteins in cerebral vessels of rats. studies on the localization of the c-met/hgf receptor in the rat brain and the int ... | 2009 | 19478261 |
| prevalence and intensity of infection with third stage larvae of angiostrongylus cantonensis in mollusks from northeast thailand. | prevalences and intensity of infection with angiostrongylus cantonensis third stage larvae were examined in mollusks to determine whether they are potential intermediate hosts in eight provinces, northeast thailand. mollusk samples were collected from 24 reservoirs (3 reservoirs/province) in close to human cases during the previous year. six out of 24 localities and 9 (3 new record species) out of 27 species were found with the infection. the highest intensity in infected species was found to be ... | 2009 | 19478262 |
| [c3c activation and intrathecal biosynthesis in children suffering from eosinophilic meningoencephalitis due to angiostrongylus cantonensis]. | eosinophilic meningoencephalitis due to angiostrongylus cantonensis is an emergent infectious disease in our area. the objective of the present paper is to determine if the activation of the complement system was taken placed with the c3c production in cerebrospinal fluid. | 2009 | 19507122 |
| angiostrongyliasis in the americas. | 2009 | 19523320 | |
| meningitis and radiculomyelitis caused by angiostrongylus cantonensis. | 2009 | 19523323 | |
| abdominal angiostrongyliasis caused by angiostrongylus cantonensis: a possible cause of eosinophilic infiltration in human digestive tract. | we report the pathological findings of a serologically proven case of angiostrongylus cantonensis presenting with localized peritonitis followed by eosinophilic meningoencephalitis. the neurological involvement developed 3 days after the occurrence of gastrointestinal symptoms. similarly to the life cycle in rats, it takes about 2 or 3 days for the larvae to reach the nervous system. the pathological section of the sigmoid colon showed focal eosinophilic infiltration with serosal vessel invasion ... | 2010 | 19545957 |
| a case of optic nerve compression caused by angiostrongylus cantonensis. | 2009 | 19556557 | |
| angiostrongylus cantonensis: effect of combination therapy with albendazole and dexamethasone on th cytokine gene expression in pbmc from patients with eosinophilic meningitis. | to determine how combination therapy with albendazole and dexamethasone changed cytokine responses in peripheral blood mononuclear cells (pbmc) in patients with eosinophilic meningitis caused by angiostrongylus cantonensis (eoma), we measured mrna levels of th2 (il-5, il-4 and il-10) and th1 (il-2 and ifn-gamma) cytokines with reverse transcription polymerase chain reaction (rt-pcr). forty-three patients were divided into three groups: group 1 (pre-treatment, 13 patients), group 2 (7 days post-t ... | 2009 | 19559022 |
| [two outbreaks of eosinophilic meningitis in yunann (china) clinical, epidemiological and therapeutical issues]. | eosinophilic meningitis is an uncommon clinical entity, which is mostly caused by angiostrongylus cantonensis, a nematode which parasitizes rat's lungs. humans represent a dead-end in the parasite's lifecycle and become infected by ingesting snails, slugs or transport hosts. due to uncontrolled proliferation and circulation of snails and rats, human angiostrongyliasis has emerged in new foci in continental china. the treatment, which relies upon a combination of albendazole and corticosteroids, ... | 2009 | 19583024 |
| induction of 2',3'-cyclic nucleotide 3'-phosphodiesterase in demyelination of balb/c mice caused by angiostrongylus cantonensis. | angiostrongylus cantonensis causes severe central nervous system (cns) infection leading to chronic demyelinating disease. the biological role of 2',3'-cyclic nucleotide 3'-phosphohydrolase (cnp) in myelin-related disease requires investigation. cnp expression was investigated in the brain of mice at six time points 5-25 days post-inoculation with a. cantonensis. cnp was measured in brain tissue by quantitative reverse transcription polymerase chain reaction and by western blotting in the cerebr ... | 2009 | 19592007 |
| [analysis on the literature concerning angiostrongylus cantonensis and angiostrongyliasis cantonensis]. | to explore the development of the study on angiostrongylus cantonensis. | 2009 | 19620081 |
| differences of proteolytic enzymes and pathological changes in permissive and nonpermissive animal hosts for angiostrongylus cantonensis infection. | in this study, mice (nonpermissive hosts) infected with angiostrongylus cantonensis showed significant worm degeneration and eosinophil degranulation, whereas infected rats (permissive hosts) showed lower worm degeneration and eosinophil degranulation. pathophysiological changes developed to a lesser extent in rat than in the mouse strains. neurological evaluation of a. cantonensis-infected mice showed mechanical damage caused by worms migrating to the brain. a significant correlation between th ... | 2009 | 19671486 |
| recognizing and reducing the risks of helminthic eosinophilic meningitis in travelers: differential diagnosis, disease management, prevention, and control. | 2009 | 19674268 | |
| eosinophilic meningitis due to angiostrongylus cantonensis in germany. | we report a case of eosinophilic meningitis due to angiostrongylus cantonensis in a patient who returned from thailand. the presence of a compatible epidemiologic history and eosinophilia in cerebrospinal fluid (csf) lead to the diagnosis, which was confirmed by detection of specific antibodies. after treatment with albendazole and corticosteroids he recovered completely. | 2009 | 19674273 |
| comparison of prednisolone plus albendazole with prednisolone alone for treatment of patients with eosinophilic meningitis. | corticosteroid and the combination of corticosteroid and antihelminthic drug are safe and beneficial in relieving headaches in patients with eosinophilic meningitis. however, clinical trials comparing the efficacies of these regimens have never been reported. we conducted a prospective, open, randomized, controlled study to compare the efficacy of the combination of prednisolone plus albendazole and prednisolone alone for the treatment of eosinophilic meningitis. our study had 53 patients in the ... | 2009 | 19706911 |
| human angiostrongyliasis outbreak in dali, china. | several angiostrongyliasis outbreaks have been reported in recent years but the disease continues to be neglected in public health circles. we describe an outbreak in dali, southwest china in order to highlight some key problems for the control of this helminth infection. | 2009 | 19771154 |
| clinical factors predictive of encephalitis caused by angiostrongylus cantonensis. | angiostrongylus cantonensis is mainly caused eosinophilic meningitis in humans, whereas a minority of patients develop encephalitic angiostrongyliasis (ea). ea is an extremely fatal condition, and the clinical factors predictive of ea have never been reported. a comparison study was conducted in a hospital situated in an endemic area of thailand. we enrolled 14 and 80 angiostrongyliasis patients who developed encephalitis and meningitis, respectively. logistic regression analysis was used to ass ... | 2009 | 19815890 |
| [expressed sequence tags (ests) analysis of angiostrongylus cantonensis]. | a total of 1,277 ests of angiostrongylus cantonensis were downloaded from genbank and analyzed with blastx. signalp v3.0 analysis was applied to predict potential putative antigen or allergen relative proteins with n-terminal secreted signal peptides or signal anchors. blastx analysis showed that there were 614 ests scored more than 100, of which 14 were identical with a. cantonensis, 60 ests did not match any proteins in the databases. the identified 614 ests could be grouped into 10 categories ... | 2009 | 19852370 |
| preliminary molecular characterization of the human pathogen angiostrongylus cantonensis. | human angiostrongyliasis is an emerging food-borne public health problem, with the number of cases increasing worldwide, especially in mainland china. angiostrongylus cantonensis is the causative agent of this severe disease. however, little is known about the genetics and basic biology of a. cantonensis. | 2009 | 19852860 |
| an outbreak of angiostrongyliasis cantonensis in beijing. | an outbreak of 81 cases of angiostrongyliasis cantonensis (ac) occurred in beijing, china, during june through september 2006. epidemiological characteristics, clinical signs and symptoms, laboratory tests, imaging, and treatment data from the 81 ac patients were collected and analyzed. all cases had a history of eating raw freshwater snails, and acquired angiostrongylus cantonensis as a result. the incubation period ranged from 1 to 36 days. the main symptoms were fever, severe headache, neck s ... | 2010 | 19874073 |
| anti-ccr3 monoclonal antibody inhibits eosinophil infiltration in angiostrongylus cantonensis-infected icr mice. | icr mice were each infected with 35 angiostrongylus cantonensis larvae. one group of mice received an intraperitoneal injection of anti-ccr3 monoclonal antibody (mab) (50 microg) at 10 days post-infection (dpi), while another similarly-treated group also received a booster injection (25 microg) at 12 dpi. all the mice were sacrificed at 14 dpi for pathological examination, enzyme-linked immunosorbent assay analysis and rna extraction. the infiltration of eosinophils and the severity of eosinophi ... | 2010 | 19887061 |
| effect of thai 'koi-hoi' food flavoring on the viability and infectivity of the third-stage larvae of angiostrongylus cantonensis (nematoda: angiostrongylidae). | the effect of the food flavoring of 'koi-hoi', a popular thai snail dish, on the viability and infectivity of angiostrongylus (=parastrongylus) cantonensis third-stage larvae was assessed in a mouse model. groups of 50 each of actively moving, non-motile coiled, and extended larvae were obtained from experimentally infected snail meat, after one-hour exposure to standard 'koi-hoi' flavoring. these larvae and groups of 50 unexposed moving larvae (control) were individually fed to each group of th ... | 2010 | 19931504 |
| alterations in the expression level of a putative aspartic protease in the development of angiostrongylus cantonensis. | aspartic proteases are a family of proteinases with catalytic aspartate residues in the active site. these enzymes have been reported to initialize the degradation of host hemoglobin in blood-feeding helminths. after identifying an expressed sequence tag representing an aspartic protease from an angiostrongylus cantonensis young adult dataset, this sequence was found to encode a protein with a predicted molecular mass of 46 kda. it also showed good homologies to aspartic proteases from caenorhab ... | 2010 | 19945419 |
| angiostrongylus cantonensis meningitis in two developmentally delayed children: findings in brain images. | 2010 | 20035209 | |
| larvicidal activities of ginger (zingiber officinale) against angiostrongylus cantonensis. | in this study, we investigated the anthelmintic activity of [6]-gingerol, [10]-shogaol, [10]-gingerol, [6]-shogaol and hexahydrocurcumin, a constituent isolate from the roots of ginger (zingiber officinale), for the parasite angiostrongylus cantonensis. this study found that the above constituents killed a. cantonensis larvae or reduced their spontaneous movements in a time- and dose-dependent manner. the larvicidal effect or ability to halt spontaneous parasite movement of [10]-shogaol, [6]-gin ... | 2010 | 20045669 |
| alicata disease: neuroinfestation by angiostrongylus cantonensis in recife, pernambuco, brazil. | 2009 | 20069226 | |
| the giant african snail achatina fulica as natural intermediate host of angiostrongylus cantonensis in pernambuco, northeast brazil. | the human cases of eosinophilic meningitis recently reported from brazil have focused the attention of the public health agencies on the role the introduced snail achatina fulica plays as hosts of the metastrongylid nematodes. determining the potential of this snail to host and develop infective larval stages of metastrongylids in the wild and identify the species harbored by them is crucial for designing effective control measures. here we assess if a. fulica may act as intermediate host of a. ... | 2010 | 20083081 |
| ocular angiostrongyliasis--first case report from jamaica. | a 30-year-old female presented with a one-month history of blurred vision in her left eye. examination revealed a live motile worm in the anterior chamber of the left eye. she also had retinal pigment epithelial disturbance with focal intraretinal haemorrhage. the 19.9 mm worm was surgically removed and identified as angiostrongylus cantonesis. she was treated with oral mebendazole. her vision improved from counting fingers in the left eye to 6/36. this is the first documented case of ocular ang ... | 2009 | 20099782 |
| finding of parastrongylus cantonensis (chen, 1935) in rattus rattus in tenerife, canary islands (spain). | parastrongylus cantonensis is a parasite of murid rodents that can infect humans and cause health problems as eosinophilic meningitis. although it is endemic in south asia, the pacific islands, australia, usa, and a few caribbean islands, it has been extended to new geographical regions. in the canary islands (spain) a survey of helminths of rattus rattus, rattus norvegicus and mus musculus domesticus was carried out. furthermore, five species of molluscs were examined for nematode larvae to det ... | 2010 | 20153283 |
| es proteins analysis of angiostrongylus cantonensis: products of the potential parasitism genes? | the expressed sequence tags (ests) of angiostrongylus cantonensis were analyzed in an attempt to gain further insight into its genomic expression patterns. a total of 1,277 ests of a. cantonensis were randomly downloaded from ncbi databank. ests were analyzed and annotated using blastx. the result showed that there were 60 ests had no match to any of the proteins and gene sequences in the published databases, and 695 ests score more than 80. according to the function, the identified 695 ests cou ... | 2010 | 20177908 |
| kinetic change of oxidative stress in cerebrospinal fluid of mice infected with angiostrongylus cantonensis. | the cerebrospinal fluid (csf) of c57bl/6 mice infected with angiostrongylus cantonensis was examined for kinetic changes in oxidative stress parameters, including reactive oxygen species (ros), superoxide dismutase (sod), catalase, malondialdehyde (mda), 8-isoprostane, and 8-hydroxy-2'-deoxyguanosine (8-ohdg). the ros increased gradually in the early stage of infection. during days 12-30 post-infection, the infected mice revealed ros levels significantly higher than that in uninfected controls ( ... | 2010 | 20196928 |
| predictive factors for encephalitis caused by angiostrongylus cantonensis infection. | 2010 | 20207885 | |
| [the first national survey on natural nidi of angiostrongylus cantonensis in china]. | to reveal the natural distribution of angiostrongylus cantonensis in the mainland of china. | 2009 | 20232636 |
| meiotic chromosomes and sex determination mechanism in thailand and hawaii isolates of angiostrongylus cantonensis (nematoda: angiostrongylidae). | angiostrongylus cantonensis, the nematode lungworm of rats, has a xx/x0 sex-determination mechanism. the chromosome constitution consists of 10 autosomes, with 2n=12, xx in the female and 2n=11, x0 in the male. meiosis-i shows five bivalents and one univalent for the male worm, and six bivalents for the female worm. the chromosome constitution of the thailand and hawaii isolates of a. cantonensis is similar to those reported for the taxa from japan, egypt and mainland china. | 2009 | 20237450 |
| [detection of circulating antigen of angiostrongylus cantonensis by 12d5 and 21b7 monoclonal antibodies.]. | to detect the rate of angiostrongylus cantonensis infection and to study the effects of treatment so as to prepare monoclonal antibodies (mcabs), and gold immunochromatography assay (gica) with 12d5 and 21b7 mcabs could be prepared in advance. | 2010 | 20302705 |
| angiostrongylus cantonensis: lesions in brain and spinal cord. | 2010 | 20348490 | |
| aquatic molluscs as auxiliary hosts for terrestrial nematode parasites: implications for pathogen transmission in a changing climate. | nematodes are common parasites of molluscs but are often overlooked. both metastrongyloid and rhabditoid species dominate the fauna within land snail and slug populations. nevertheless, a key characteristic of many laboratory studies is the ability of these terrestrial nematodes to utilize aquatic molluscs as auxiliary hosts. the significance of this to the ecology of the parasite has never been evaluated. there is increasing concern as to the impact of climate change on the epidemiology of many ... | 2010 | 20388234 |
| alterations of myelin proteins in inflammatory demyelination of balb/c mice caused by angiostrongylus cantonensis. | angiostrongylus cantonensis causes eosinophilic meningitis or meningoencephalitis, yet little is known about demyelination caused by this parasite. to define the course of demyelination caused by a. cantonensis, we analyzed the expression of myelin proteins including myelin-associated glycoprotein (mag), myelin basic protein (mbp), myelin-associated oligodendrocytic basic protein (mobp), and proteolipid protein (plp) in brain and cerebrospinal fluid (csf)-like fluid of infected and uninfected ba ... | 2010 | 20399564 |
| [survey on the focus of angiostrongylus cantonensis in guangdong province]. | to understand the distribution of angiostrongylus cantonensis foci in guangdong province for making surveillance program. | 2010 | 20411741 |
| [severe angiostrongyliasis cantonensis in a toddler]. | 2010 | 20411758 | |
| oxidative stress in mice infected with angiostrongylus cantonensis coincides with enhanced glutathione-dependent enzymes activity. | this study aimed to estimate reactive oxygen species (ros) production, antioxidants activity, and biomarkers level of oxidative damage to protein and dna in the cerebrospinal fluid (csf) of c57bl/6 mice infected with angiostrongylus cantonensis. the mean ros concentration in the csf of infected mice increased gradually, and the increase in ros in csf became statistical significance at days 12-30 post-infection compared to that before infection (p<0.001), and then ros returned to normal level at ... | 2010 | 20433832 |
| [angiostrongylosis or eosinophilic meningitis]. | eosinophilic meningitis, or angiostrongyliasis, is a common disease in asia, in the caribbean and in the pacific islands. it is caused by a rat lungworm angiostrongylus cantonensis. infection occurs by consumption of raw or undercooked snails. diagnosis is based on epidemiological criteria, clinical manifestations, elevated count of eosinophils in the cerebrospinal fluid and serological tests. treatment is symptomatic and supportive. | 2010 | 20465114 |
| reibergram of intrathecal synthesis of c4 in patients with eosinophilic meningitis caused by angiostrongylus cantonensis. | angiostrongylus cantonensis produces eosinophilic meningitis in humans and is endemic in thailand, taiwan, china, and the caribbean region. during infection with this parasite, it is important to know if the complement system may be activated by the classical or lectin pathway. cerebrospinal fluid and serum samples from 20 patients with meningitic angiostrongyliasis were used to quantify c4 levels and albumin. results were plotted on a c4 csf/serum quotient diagram or reibergram. twelve patients ... | 2010 | 20519605 |
| improved molecular detection of angiostrongylus cantonensis in mollusks and other environmental samples with a species-specific internal transcribed spacer 1-based taqman assay. | angiostrongylus cantonensis is the most common cause of human eosinophilic meningitis. humans become infected by ingesting food items contaminated with third-stage larvae that develop in mollusks. we report the development of a real-time pcr assay for the species-specific identification of a. cantonensis in mollusk tissue. | 2010 | 20543049 |
| molecular differentiation and phylogenetic relationships of three angiostrongylus species and angiostrongylus cantonensis geographical isolates based on a 66-kda protein gene of a. cantonensis (nematoda: angiostrongylidae). | the phylogenetic relationships and molecular differentiation of three species of angiostrongylid nematodes (angiostrongylus cantonensis, angiostrongylus costaricensis and angiostrongylus malaysiensis) were studied using the ac primers for a 66-kda protein gene of a. cantonensis. the ac primers successfully amplified the genomic dna of these angiostrongylid nematodes. no amplification was detected for the dna of ascaris lumbricoides, ascaris suum, anisakis simplex, gnathostoma spinigerum, toxocar ... | 2010 | 20566366 |
| molecular cloning and characterization of cystatin, a cysteine protease inhibitor, from angiostrongylus cantonensis. | cystatins are thiol proteinase inhibitors ubiquitously present in mammalian body and serve various important physiological functions. in the present study, a novel cystatin molecule (accystatin) was cloned from a cdna library of angiostrongylus cantonensis fourth-stage larvae. the putative 14-kda protein contained 120 residues with cystatin-conserved motifs known to interact with the active site of cysteine peptidases and showed high identities with cystatins from other nematodes. rt-pcr analysi ... | 2010 | 20567985 |
| efficacy of combined treatment with albendazole and baicalein against eosinophilic meningitis induced by angiostrongylus cantonensis in mice. | angiostrongylus cantonensis infection causes eosinophilic meningitis in humans. baicalein is a flavonoid originally isolated from the roots of scutellaria baicalensis georgi. in this study we evaluated the efficacy of the combination of albendazole and baicalein for treating eosinophilic meningitis in balb/c mice. therapeutic efficacy included the survival time, body weight, neurological function, leucocyte and eosinophil counts, eotaxin concentration, matrix metalloproteinase-9 (mmp-9) activity ... | 2011 | 20587113 |
| molecular differentiation of angiostrongylus taxa (nematoda: angiostrongylidae) by cytochrome c oxidase subunit i (coi) gene sequences. | nematodes of the genus angiostrongylus are parasites of rodents and carnivores. they reside in the pulmonary or mesenteric arteries of their hosts. two species are pathogenic in humans -angiostrongylus cantonensis causes eosinophilic meningitis or meningoencephalitis, and angiostrongylus costaricensis produces abdominal angiostrongyliasis. in addition angiostrongylus malaysiensis may have the potential of being pathogenic in humans. the mitochondrial gene cytochrome c oxidase subunit i (coi) of ... | 2010 | 20654571 |
| drug target in eosinophilic meningitis caused by angiostrongylus cantonensis. | eosinophilic meningitis caused by angiostrongylus cantonensis is an emerging infectious disease. it is the most common form of human angiostrongyliasis. the diagnosis is made by clinical criteria including the presence of cerebrospinal fluid eosinophils and a history of exposure to a. cantonensis larvae, e.g., from raw freshwater snails or contaminated vegetables. among various treatment options, corticosteroid is the only effective treatment. | 2010 | 20701570 |
| assessment of skin penetration of third-stage larvae of strongyloides ratti. | strongyloides stercoralis infection is caused by skin penetration of third-stage larvae (l3s). we studied skin penetration of l3s of strongyloides ratti using an in vitro assay that has been used previously to study angiostrongylus cantonensis, an agarose membrane with a temperature gradient, and scanning electron microscopy. our results revealed that skin penetration of l3s depended on host skin temperature. when the target temperature of the outer liquid was 37°c, more than 80% of l3s penetrat ... | 2010 | 20714751 |
| detection of anti-oxidant enzymatic activities and purification of glutathione transferases from angiostrongylus cantonensis. | there are several anti-oxidant enzyme families that play pivotal roles in facilitating the survival of parasites. glutathione transferases (gsts) are members of the anti-oxidant family that can detoxify a broad range of exogenous or endogenous compounds including reactive oxidative species. gsts have been studied as vaccine candidates, immunodiagnostic markers and as treatment targets. helminths of the genus angiostrongylus live inside arteries of vertebrates and two main species are associated ... | 2011 | 20807531 |
| helminthic infections mimicking malignancy: a review of published case reports. | infectious diseases, including infections with helminths, can initially present similarly to malignancies. the goal of the article is to review reports of helminthic infections that are initially diagnosed as malignancy. | 2010 | 20818089 |
| monoclonal antibodies against excretory/secretory antigens of angiostrongylus cantonensis. | in the present study, four murine monoclonal antibodies (mabs) were generated against the excretory/secretory (es) products of angiostrongylus cantonensis adult worms; two represented igg1 and two represented igm mabs, and they were designated 12d5, 15f8, 21b7 and 14g10, respectively. immunoblotting revealed that all of the mabs predominantly recognized a 98 kda antigen in the es products of a. cantonensis adult worms, and no cross reactions were found with the whole worm antigens of some other ... | 2010 | 21050048 |
| application of recombinant smr-domain containing protein of angiostrongylus cantonensis in immunoblot diagnosis of human angiostrongyliasis. | the aim of this study was to find novel proteins expressed from an angiostrongylus cantonensis adult female worm cdna library for serodiagnosis of angiostrongyliasis. an immuno-dominant clone, fac22, was identified by immunoscreening with pooled positive sera from proven angiostrongyliasis patients. the clone contained an open reading frame of 2,136 bp encoding a 80.5 kda protein with a predicted isoelectric point of 5.8. the deduced amino acid sequence (712 amino acids) contained the conserved ... | 2010 | 21073053 |
| uptake and utilization of arachidonic acid in infective larvae of angiostrongylus cantonensis. | infective larvae of angiostrongylus cantonensis may take up and incorporate exogenous arachidonic acid into their lipid pool. by scintillation counting, uptake and incorporation were determined to be time dependent. arachidonic acid was mainly incorporated into phospholipid (56.8%) and neutral lipid (22.4%) pools. in the neutral lipids, 64.0% was diglyceride and 36.0% triglyceride. phosphatidylcholine was the predominant fatty acid in the phospholipid pool. in addition to the release of leukotri ... | 2010 | 21106133 |
| the effects of different plant extracts on nematodes. | the anthelminthic efficacy of some differently obtained extracts of several plants was tested in vivo in laboratory animals and in vitro. the extracts were obtained by ethanolic, methanolic, aqueous, or chloroform, respectively, acetonitrile polyethylenglycol (peg) and/or propylencarbonate (pc) elution at room temperature or at 37°c. the plants used were bulbs of onions, garlic, chives, coconut, birch tree, ananas, cistrose, banana, chicory, date palm fruit, fig, pumpkin, and neem tree seeds. th ... | 2010 | 21110041 |
| images in clinical tropical medicine. myelitis caused by infection of angiostrongylus cantonensis. | 2010 | 21118917 | |
| use of heterologous antigens for the immunodiagnosis of abdominal angiostrongyliasis by an enzyme-linked immunosorbent assay. | angiostrongylus costaricensis has a broad geographic distribution spanning from north to south america and the infections of vertebrates with this nematode can result in abdominal complications. human infections are diagnosed by histological or serological methods because the isolation of larvae from feces is not feasible, as most parasites become trapped in intestinal tissues due to intense eosinophilic inflammation. because a. costaricensis is difficult to maintain in the laboratory, an immuno ... | 2010 | 21120363 |
| first report of angiostrongylus cantonensis (nematoda: metastrongylidae) in achatina fulica (mollusca: gastropoda) from southeast and south brazil. | the rat lungworm angiostrongylus cantonensis is a worldwide-distributed zoonotic nematode that can cause human eosinophilic meningoencephalitis. here, for the first time, we report the isolation of a. cantonensis from achatina fulica from two brazilian states: rio de janeiro (specifically the municipalities of barra do piraí, situated at the paraiba river valley region and são gonçalo, situated at the edge of guanabara bay) and santa catarina (in municipality of joinville). the lungworms were id ... | 2010 | 21120369 |
| [two patients with chronic meningitis due to angiostrongylus cantonensis]. | 2011 | 21246496 | |
| neuroangiostrongyliasis and other parasites in tawny frogmouths (podargus strigoides) in south-eastern queensland. | the neurological, clinical and pathological findings and endoparasites in 10 wild tawny frogmouths (podargus strigoides) presented to the australian wildlife hospital in beerwah, queensland during a 28-day period in may 2009 are reported. affected birds had a history of being found in poor body condition on the ground and unable to fly. clinical examination revealed paresis with variable but generally weakened deep pain responses, withdrawal reflexes and an inability to perch. severely affected ... | 2011 | 21250956 |
| human ocular angiostrongyliasis: a literature review. | human ocular angiostrongyliasis caused by angiostrongylus cantonensis infection in the eye is a very rare condition. until now, there has been no comprehensive analysis of this disease. we searched and analysed the references found on the internet that refer to human ocular angiostrongyliasis and reviewed the aetiology, clinical manifestations, diagnosis, epidemiology and treatment of the condition. twenty-six references were found reporting 35 patients from 10 countries that were diagnosed with ... | 2011 | 21296846 |
| epidemiological survey of angiostrongylus cantonensis in the west-central region of guangdong province, china. | the study was to understand the angiostrongylus cantonensis infectious situation of rodent definitive host, snail intermediate host, and local residents in the west-central region of guangdong province in china. the snails achatina fulica and pomacea canaliculata collected from the survey place were digested with artificial gastric juice, and the third-stage larvae of a. cantonensis in the snails were examined under microscope. the heart and lung of rats captured from the survey place were taken ... | 2011 | 21301874 |
| molecular cloning and characterization of a cathepsin b from angiostrongylus cantonensis. | cysteine proteases, a superfamily of hydrolytic enzymes, have numerous functions in parasites. here, we reported the cloning and characterization of a cdna encoding a cathepsin b (accpb) from angiostrongylus cantonensis fourth-stage larvae cdna library. the deduced amino acid sequence analysis indicated accpb is related to other cathepsin b family members with an overall conserved architecture. accpb is evolutionarily more close to other parasitic nematode cathepsin b than the ones from hosts, s ... | 2011 | 21344211 |
| seroprevalence of angiostrongylus cantonensis infection in humans in china. | a seroepidemiological survey was carried out in china during 2009-2010 to determine the extent of circulating antigens (cag) for angiostrongylus cantonensis in the chinese population using the gold immunochromatographic assay, with the objective of elucidating the nationwide prevalence of angiostrongyliasis in china. a total of 1,730 blood samples was collected and assayed from the general adult population (the "general group"), and those involved in aquaculture or processing of snails achatina ... | 2010 | 21348622 |
| [multiplex pcr assay for the detection of angiostrongylus cantonensis larvae in pomacea canaliculata]. | to establish a multiplex pcr assay for detecting angiostrongylus cantonensis larvae in pomacea canaliculata. | 2010 | 21351548 |
| angiostrongylus cantonensis: identification and characterization of micrornas in male and female adults. | angiostrongylus cantonensis causes eosinophilic meningitis and eosinophilic pleocytosis in humans and is of significant socio-economic importance globally. micrornas (mirnas) are endogenous small non-coding rnas that play crucial roles in gene expression regulation, cellular function and defense, homeostasis and pathogenesis. they have been identified in a diverse range of organisms. the objective of this study was to determine and characterize mirnas of female and male adults of a. cantonensis ... | 2011 | 21356210 |
| comparison of major immunoglobulins intrathecal synthesis patterns in ecuadorian and cuban patients with angiostrongyliasis. | angiostrongylus cantonensis meningitis was first reported in cuba in 1981, and it was recently reported in south america. the aim of this paper is to evaluate the intrathecal immunoglobulin synthesis patterns from cuba's and ecuador's patients with angiostrongyliasis; 8 ecuadorian patients from two different outbreaks and 28 cuban patients were studied. simultaneous blood and cerebrospinal fluid samples were taken. immunoglobulin (ig) a, igm, igg, and albumin were quantified by radial immunodiff ... | 2011 | 21363978 |
| the rat lung-worm angiostrongylus cantonensis: a first report in south africa. | 2011 | 21382247 | |
| [two cases of chronic meningitis due to angiostrongylus cantonensis]. | 2011 | 21425117 | |
| encephalitis caused by angiostrongylus cantonensis after eating raw frogs mixed with wine as a health supplement. | angiostrongylus cantonensis also known as the rat lungworm, is prevalent in the pacific islands and southeast asia and is the most common cause of eosinophilic meningitis in humans. although frogs and toads are known as paratenic hosts of a. cantonensis, they are rarely reported as the infectious source of human angiostrongyliasis. we report a case of encephalitis caused by angiostrongylus cantonensis after eating raw frogs mixed with wine as a health supplement. prednisolone at a dose of 1 mg/k ... | 2011 | 21467715 |
| [the immunopathology mechanisms of matrix metalloproteinases in brain infection induced by parasites]. | matrix metalloproteinase (mmp) family is a class of endogenous peptidases involved in normal physiological processes of the body, such as embryonic development, wound healing, angiogenesis, cartilage absorption, etc. however, during infection, over-expression of activated matrix metalloproteinase can lead to immunopathological change, induce disease or death, also contribute to the spread or survival of pathogens. some human parasites such as plasmodium, toxoplasma gondii, cysticercus cellulosae ... | 2010 | 21500539 |
| development of a double antibody sandwich elisa assay for the diagnosis of angiostrongyliasis. | abstract abstractusing two monoclonal antibodies (mabs) against excretory/secretory (es) antigens of angiostrongylus cantonensis adult worms, a method of double antibody sandwich elisa for the detection of circulating antigens (cag) was established with the best experimental conditions regulated for performance. to evaluate the sensitivity, the cag in sera of rats (80) and mice (15) infected with a. cantonensis as well as cag in sera of clinical confirmed angiostrongyliasis patients (70) were de ... | 2011 | 21506824 |
| lung ct findings of angiostrongyliasis cantonensis caused by angiostrongylus cantonensis. | angiostrongyliasis cantonensis is a parasitic disease caused by human infection with angiostrongylus cantonensis. fifteen cases were enrolled in our study. chest ct scanning was performed with msct in all cases. the chest ct images demonstrated that pulmonary nodular lesions and ground-glass opacity lesions located in the subpleural area are the characteristic signs of the disease. with the development of the disease, ground-glass opacity lesions disappear and pleural indentation occurs. | 2011 | 21513853 |
| specific detection of angiostrongylus cantonensis in the snail achatina fulica using a loop-mediated isothermal amplification (lamp) assay. | angiostrongylus cantonensis, a rat lungworm, can cause eosinophilic meningitis and angiostrongyliasis in humans following ingestion of contaminated foods or intermediate/paratenic hosts with infective larvae. the snail achatina fulica is one of the important intermediate hosts of a. cantonensis and is commonly eaten by humans in some countries. in the present study, we developed a loop-mediated isothermal amplification (lamp) method for the specific detection of a. cantonensis in ac. fulica. pri ... | 2011 | 21515360 |
| clinical manifestations of eosinophilic meningitis caused by angiostrongylus cantonensis: 18 years' experience in a medical center in southern taiwan. | background: with the improvement of public health, eosinophilic meningitis associated with angiostrongylus cantonensis infection is now seldom reported in taiwan. eosinophilic meningitis typically occurred sporadically in children. this study aims to analyze the clinical manifestations and change in the contemporary epidemiology of eosinophilic meningitis in taiwan. methods: this is a retrospective study of patients diagnosed with eosinophilic meningitis at kaohsiung veterans general hospital, f ... | 2011 | 21524976 |
| eosinophilic meningitis risk associated with raw ampullarium canaliculatus snails consumption. | in taiwan, angiostrongylus cantonensis infection has been reported in foreign laborers who had consumed raw ampullarium canaliculatus snails. this study analyzed three foreign laborers who had contracted enzyme-linked immunosorbent assay-confirmed a cantonensis infection while working in taiwan. all three workers had consumed either roasted snails or raw snails flavored with seasoning while drinking wine. this study investigated possible risk factors for a cantonensis, including naturally occurr ... | 2011 | 21527185 |
| a transcriptomic study on the pepsin-activated infective larvae of angiostrongylus cantonensis. | to investigate the pepsin-activated infective (third-stage) larvae of angiostrongylus cantonensis at the transcriptomic level, 1496 ests were generated from a cdna library and clustered into 161 contigs and 757 singletons. among these unigenes, 54.5% had significant sequence homology with known proteins. the most abundantly expressed transcripts were cathepsin b-like cysteine protease 1 and 2, metalloprotease i, metalloprotease 1 precursor, and extracellular superoxide dismutase. protein complex ... | 2011 | 21624399 |
| human angiostrongylus cantonensis: an update. | angiostrongylus cantonensis was first discovered in 1935 and has become an important emerging pathogen causing human angiostrongyliasis. major outbreaks of human angiostrongyliasis have been reported in endemic regions. thousands of cases of human angiostrongyliasis have been documented worldwide. a. cantonensis has spread from its traditional endemic regions of the pacific islands and southeast asia to the american continent including the usa, caribbean islands and brazil. humans acquire a. can ... | 2011 | 21725905 |
| neuroimmunological findings of angiostrongylus cantonensis meningitis in ecuadorian patients. | meningitis caused by angiostrongylus cantonensis has recently been reported in patients resulting from the first outbreaks in subtropical regions of ecuador. | 2011 | 21755123 |
| endemic angiostrongyliasis, rio de janeiro, brazil. | to the editor: the nematode angiostrongylus cantonensis (rat lung worm), a zoonotic parasite that can accidentally infect humans and cause eosinophilic meningoencephalitis, has the norway rat (rattus norvegicus) as one of its most frequent definitive vertebrate hosts (1). adult worms live in the pulmonary arteries of the definitive hosts, which excrete first-stage larvae in their feces. intermediate hosts, such as snails and slugs, are infected by first-stage larvae, which reach the infective th ... | 2011 | 21762612 |
| enzootic angiostrongyliasis, guangdong, china, 2008-2009. | to the editor: the nematode angiostrongylus cantonensis was discovered in pulmonary arteries and hearts of domestic rats in guangzhou (canton), china, by chen in 1935 (1). this parasite has a complex life cycle (2) and causes cerebral angiostrongyliasis after ingestion of infective larvae found in freshwater and terrestrial snails and slugs, paratenic hosts (such as freshwater fish, shrimp, frogs, and crabs), and contaminated vegetables (3). | 2011 | 21762614 |
| epidemic status of angiostrongylus cantonensis in hainan island, china. | to understand the current epidemiological status of angiostrongylus cantonensis in hainan island and provide the scientific evidences for prevention and control of the disease. | 2011 | 21771469 |