Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [occurrence of aspergillus fumigatus in west berlin - contribution to the epidemiology of aspergillosis (author's transl)]. | the increasing incidence of human a. fumigatus infections particularly such of the respiratory tract has led to this study of the epidemiological situation. during the period between october 1968 and december 1977, a. fumigatus was isolated from clinical material in 425 cases. these findings which were established at the mycology unit, robert koch institute, federal health office, exhibited the following distribution by regions of the body or type of specimen: respiratory tract 277 (65.1(); veno ... | 1978 | 364887 |
| isolation of dna from aspergillus nidulans. | a procedure for isolation of dna from aspergillus nidulans on a preparative scale is described. mechanical disruption of lyophilized material in high-salt medium and treatment with proteinase k, followed by sedimentation of the lysate into saturated csc1 solution yielded pure, highly polymerized dna. | 1978 | 364902 |
| cystic fibrosis, atopy, and airways lability. | in a survey of cystic fibrosis (cf) in the avon area, 48 children with cf from 40 families together with 71 of their parents were studied by spirometry, exercise tests, and pinch tests. a control group of 42 young adults was similarly tested; control data for children were taken from previously published work. the prevalence of atopy (any positive prick test) in children with cf was 48%. sensitivity to grass pollens and house dust mite was no more common in these children (29%) than in a normal ... | 1978 | 365112 |
| immunodiagnosis of systemic aspergillosis. i. antigenemia detected by radioimmunoassay in experimental infection. | because systemic aspergillosis is difficult to diagnose ante mortem, a study to improve immunodiagnosis was undertaken in a rabbit model of disseminated infection. we found that the predominant humoral response of infected animals was directed against four aspergillus antigens identified by crossed immunoelectrophoresis. one of these antigens, a cell-wall carbohydrate, was purified by gel-filtration chromatography and was used to develop a radioimmunoassay. the sensitivity of this assay was incr ... | 1979 | 366048 |
| some pulmonary manifestations of allergy. | 1978 | 366356 | |
| experimental mycosis in immunosuppressed rabbits. ii. acute and chronic aspergillosis. | the influence of immunosuppression on the course of experimental aspergillosis was investigated. rabbits (2.2--2.5 kg) were divided into four groups. group one received no drugs and was given 10(6) spores intravenously (iv) or intratracheally (it) on two occasions one week apart. weight gain or loss, appearance or disappearance of aspergillus antigen and/or antibody, and detection of aspergillosis at autopsy were followed. group 2 received weekly injections of cyclophosphamide (70 mg/kg) startin ... | 1978 | 366426 |
| [presence of sexual forms (cleistothecia and hülle cells) in a case of human maxillary sinus aspergillosis caused by aspergillus nidulans in association with aspergillus fumigatus]. | the authors observed, in a biopsic sample from a human maxillary sinus, the coexistence, in parasitic stages, of two different aspergillus species: a. fumigatus and a. nidulans. after having described the morphologies of each species, in sections on slides, and particularly those of cleistothecia and hülle-cells for the second, they draw attention to the three interests of such an observation: -- rarety of observing aspergillus nidulans in a parasitic stage, in spite of its particular thermotole ... | 1978 | 366429 |
| immunohistochemical observation of lysozyme in macrophages and giant cells in human granulomas. | lysozyme activity of macrophages and giant cells in various human granulomas were examined with immunoperoxidase bridge method in tissue sections. various numbers of epithelioid cells and giant cells of epithelioid cell granulomas of tuberculosis, sarcoidosis and crohn's disease exhibited intense granular cytoplasmic lysozyme activity. foreign body granulomas induced with various substances showed negative or faintly positive lysozyme stain. macrophages and giant cells of aspergillus granuloma a ... | 1978 | 367052 |
| aspects of the molecular biology of lipoamide dehydrogenase. | 1978 | 367117 | |
| [treatment of severe forms of aspergillosis-related pneumonia]. | 1978 | 368427 | |
| an "up-promotor" mutation affecting the acetamidase of aspergillus nidulans. | a derivative of an area200 strain of aspergillus nidulans selected for strong growth on acetamide as the sole nitrogen source was found to have a mutation, amd-18, closely linked to amds, the acetamidase structural gene. this mutation results in 2--3 fold higher acetamidase activities than wildtype strains in uninduced as well as induced cultures. the effects of the amd-18 mutation are superimposed on the effects of other regulatory mutations affecting the acetamidase. the amd-18 mutation is cis ... | 1978 | 368568 |
| lactam utilisation in aspergillus nidulans: evidence for a fourth gene under the control of the integrator gene inta. | mutations in the lama gene of aspergillus nidulans prevent the conversion of exogenous 2-pyrrolidone (gamma-butyrolactam) to gamma-amino-n-butyrate (gaba) and also prevent the (probably analogous) utilisation of 2-piperidone (sigma-valerolactam). the lama gene, in linkage group viii, probably specifies a lactamase but a rôle in lactam uptake cannot be ruled out. lama is probably under the control of the positive acting regulatory gene inta, which can integrate its expression with the expression ... | 1978 | 368580 |
| [evaluation of nonlyophilized and lyophilized metabolic antigens of aspergillus fumigatus using the precipitation test]. | 1979 | 368734 | |
| [pathomorphological studies of spontaneous and experimental abortions in cows and guinea pigs]. | the morphologic studies of aspergillosis abortions in cows and guinea pigs were carried out on 83 spontaneously affected aborted cattle fetuses, pregnant guinea pigs and their offsprings. fifty-four fetuses were of spontaneously aborted cows from 12 farms along with 15 pregnant guinea pigs experimentally infected with aspergillus fumigatus and a total of 14 fetuses of theirs. microscopically, both in the cattle fetuses and in guinea pigs and their fetuses there were stasis, thrombosis, diapedeti ... | 1978 | 369113 |
| [progress in the therapy of systemic mycoses]. | 1978 | 369201 | |
| [comparative study of glycosidase from cattle liver and exoglycanase from aspergillus awamori]. | anomerities of products were estimated for glucosidases from cattle liver and aspergillus awamori. it was demonstrated that the enzyme from cattle liver is alpha-glucosidase and that from asp. awamori is exogluconase. it was demonstrated that alpha-glucosidase hydrolyzes the c1--o bond in the course of reaction. delta-lactone of gluconic acid is a competitive inhibitor for both enzymes. the secondary kinetic isotope effects for both enzymes were measured. the isotope effect for alpha-glucosidase ... | 1978 | 369619 |
| regulatory properties of pyruvate carboxylase from aspergillus nidulans: evidence for the presence of a masked activator site [proceedings]. | 1978 | 369914 | |
| non-specific potentiation of ige by parasitic infections in man. | infection with the helminthic parasites ascaris lumbricoides and/or necator americanus (hookworm) induces the production in man of high levels of serum ige. the specificity of this ige antibody when measured by rast to a wide range of allergens was restricted in general to the helminthic antigens. absorption of the sera with immunosorbents produced by coupling extracts of a. lumbricoides to cnbr activated sepharose 4b established that ascaris antigen specific ige antibodies contributed a minor f ... | 1979 | 370030 |
| acute allergic alveolitis. | 1979 | 370393 | |
| [use of a pyrimidine-dependent mutant for effective labeling of the dna of aspergillus nidulans]. | incorporation of the radioactive label from pyrimidines into rna and dna of an aspergillus nidulans pyrimidine-dependent mutant was studied. the label from [14c2]uridine was incorporated at the highest rate into both fractions of nucleic acids from a. nidulans of the wild type and pyr-mutant. the content of the label in the dna of the pyr-mutant was several times higher than that in the wild type dna. therefore, pyr-mutants can be used in order to study molecular-genetic processes in the cells o ... | 1978 | 370508 |
| [metabolic pathways of exogenous pyrimidines in aspergillus nidulans]. | studies on the susceptibility of the wild-type strain of aspergillus nidulans to 6-azauracil suggest that it synthesizes pyrimidines using a by-pass pathway which is induced with 6-azauracil. the effect of a series of pyrimidines on the toxic action of 5-fluorouracil, 5-fluorouidine and 5-fluorodeoxyuridine has been investigated. as the result of these studies, a scheme is proposed for the metabolism of some pyrimidine bases and nucleosides in aso. nidulans. | 1979 | 370519 |
| mutagenicity to salmonella typhimurium of some aspergillus and penicillium mycotoxins. | 17 mycotoxins produced by various aspergillus and penicillium species were screened for their mutagenic activity to salmonella typhimurium strains ta98, ta100, ta1535 and ta1537, both with and without metabolic activation. austdiol, austocystins a and d, kojic acid and viridicatumtoxin were found to be mutagenic after metabolic activation, while austdiol was also mutagenic per se. aflatoxin b1, sterigmatocystin and versicolorin a, which were used as positive controls were also mutagenic. no muta ... | 1978 | 370570 |
| fungal toxins as a parasitic factor responsible for the establishment of fungal infections. | although the mechanism of fungal infections, particularly that of opportunistic fungus infections, has been studied extensively, much still remains to be clarified. as is the case of certain bacterial infections, it has long been assumed by numerous investigators that some toxins, enzymes and other metabolites produced in vitro as well as in vivo by pathogenic fungi or their cellular constituents might be responsible for the establishment of fungal infections. however, there are very few papers ... | 1978 | 370602 |
| virulence genetics of aspergillus nidulans eidam: a review. | studies of the influence of genotypic alterations on the murine virulence of aspergillus nidulans eidam are reviewed to emphasize the potential of this fungus for genetic studies of virulence. | 1978 | 370604 |
| a general method for maximizing the expression of a cloned gene. | we present a method, utilizing a combination of restriction endonuclease cleavage and digestion with escherichia coli exonuclease iii and aspergillus orizae nuclease s1, that allows us to position a restriction fragment bearing the promoter of the lacz gene of e. coli at virtually any distance in front of any cloned gene. in particular, we have used this method to examine the effect on protein production of gene-promoter separation for the cro gene of phage lambda and to produce plasmids that, u ... | 1979 | 370836 |
| transurethral passage of aspergillus fungus balls in acute myelocytic leukemia. | a patient with acute myelocytic leukemia who had a chronic febrile illness during the induction of remission of leukemia developed asymptomatic discrete pulmonary infiltrates which rapidly evolved into cavities containing homogeneous opacities. over the next five weeks, the cavities resolved without specific treatment. the patient subsequently passed large fungus balls in the urine, and the diagnosis of disseminated aspergillosis was made. a course of intravenous amphotericin b therapy was compl ... | 1979 | 371013 |
| allergy in cystic fibrosis. | forty-four patients with cystic fibrosis, sixty-seven parents, and thirty-nine controls were compared with regard to their immediate cutaneous hypersensitivity, total and specific serum ige and serum igg4 concentrations. the patients had increased prick test reactions and specific ige to aspergillus fumigatus. the development of reactions to a. fumigatus correlated with the severity of the disease. there were no other significant differences when serum total ige, specific ige and igg4 concentrat ... | 1979 | 371883 |
| acute disseminated aspergillosis during the neonatal period. report of an instance in a 14-day-old infant. | we describe an infant who died with extensive lesions of disseminated aspergillosis on the 18th day of postnatal life. aspergillus fumigatus was recovered from blood cultures. initial clinical manifestations were suggestive of hepatitis, and steroids and antibiotics were used in the treatment. this therapy may have fostered the onset of an opportunistic mycosis. advanced multisystemic aspergillotic lesions were seen at autopsy, especially prominent in lungs and gastrointestinal tract. the extent ... | 1979 | 371889 |
| characterization of subunits from fatty acid synthetase in fungi [proceedings]. | 1979 | 372037 | |
| induced quantitative variation for penicillin titre in clonal populations of aspergillus nidulans. | the variation in penicillin titre within populations of cultures of aspergillus nidulans derived from untreated conidia and from conidia treated with ethyl methanesulphonate (ems), near-ultraviolet light in the presence of 8-methoxypsoralen (8mop) or n-methyl-n'-nitro-n-nitrosoguanidine (ntg), each at several dose levels, was determined. both mutagentreated and untreated populations showed a continuous distribution of pencillin titres. the population mean titre of the mutagenized populations was ... | 1979 | 372487 |
| invasive pulmonary aspergillosis associated with influenza. | fatal invasive pulmonary aspergillosis may follow viral influenza infections. two cases with verified influenza a infection were followed by fatal necrotizing pneumonia due to aspergillus fumigatus. both patients demonstrated cutaneous anergy and lymphocytopenia. influenza and perhaps other viruses that depress t-cell function may result in increased susceptibility to infections in which t cells are important in host defenses. | 1979 | 372590 |
| induced segregation in interspecific hybrids of aspergillus nidulans and aspergillus rugulosus obtained by protoplast fusion. | interspecific hybrids produced by polyethylene glycol induced fusion of protoplasts from auxotrophic mutants of aspergillus nidulans and aspergillus rugulosus were grown in the presence of the recombinogens benomyl and chloral hydrate to stimulate segregation. the a. nidulans parental strains used had a known genetic marker in each linkage group. hybrids grown on complete medium containing benomyl yielded more segregants. analysis of the segregants showed that the distribution of a. nidulans lin ... | 1979 | 372762 |
| [two cases of pulmonary aspergilloma (author's transl)]. | 1978 | 373022 | |
| [cases of aspergillus mastitis in cattle]. | 1979 | 373748 | |
| studies of the carbohydrate residues of glycoproteins by natural abundance carbon 13 nuclear magnetic resonance spectroscopy. glucoamylase from aspergillus niger. | 1979 | 374412 | |
| combined amphotericin b-flucytosine therapy in aspergillus pneumonia. | the incidence of aspergillosis is increasing while the prognosis remains dismal. standard single-drug therapy with amphotericin b offers unacceptably low cure rates. a patient with aspergillus pneumonia was treated with a synergistic combination of amphotericin b and flucytosine. a prompt clinical response and progressive resolution of the infection were observed. combination therapy appeared to decrease the dose of amphotericin b needed for effective therapy. it may provide improved results wit ... | 1979 | 374761 |
| [aspergillus endocarditis following aortic valve replacement]. | 1979 | 374821 | |
| cis-dominant regulatory mutations affecting the expression of gaba permease in aspergillus nidulans. | in aspergillus nidulans expression of the gaba gene, the probable structural gene for the gamma-amino-n-butyrate (gaba) permease, is controlled by induction, via the inta gene, ammonium repression, mediated by the area gene, and probably carbon catabolite repression. regulatory mutations, tightly linked to gaba, were selected by reverting an arear-2 strain on gaba as nitrogen source. these mutations, gabi-1, gabi-2, and gabi-3 result in increased gaba expression and are cis-dominant in their eff ... | 1979 | 375001 |
| the regulation of hexokinase and phosphoglucomutase activity in aspergillus nidulans. | the levels of glucose-6-phosphate and 6-phosphogluconate dehydrogenase in wildtype cells of aspergillus nidulans varied with the carbon and nitrogen source. in general, hexokinase activity did not vary with carbon or nitrogen source. the ammonium derepressed mutant amra1 had only 50% of the wildtype level of hexokinase. phosphoglucomutase activity was low in wildtype cells grown with nitrate, but high in cells grown with ammonium when glucose was the carbon source. a non-inducible mutant, nira-1 ... | 1979 | 375022 |
| molecular cloning of the 4.2 md ecori fragment of aspergillus nidulans mitochondrial dna. | the 4.2 md ecori fragment of aspergillus nidulans mitochondrial dna was cloned using the plasmid pbr 332 as vector and e. coli as host. hitherto unknown sequence of hindiii sites within this region of mitochondrial genome was established. | 1979 | 375024 |
| the ability of ionizing radiations of different let to induce chromosomal deletions in aspergillus nidulans. | conidia, derived from a strain of aspergillus nidulans known to carry a specific chromosomal duplication, were irradiated. the duplicated segment had genetic markers, which, when eliminated from the genome, allowed the easy detection of deletion mutants. survival curves derived following 15 mev electron and gamma-ray irradiation were characterised by the presence of an appreciable shoulder, whilst 50 kvp x-rays gave a much smaller shoulder. irradiation with beta-particles and alpha-particles gav ... | 1979 | 375074 |
| [in vitro toxigenesis of aspergillus fumigatus strain. production of fumitoxins]. | a new class of mycotoxins has been characterized from a strain of aspergillus fumigatus: the fumitoxins a, b, c and d. the in vitro production of these metabolites is studied. fumitoxins are common in cultures extracts of most strains of a. fumigatus. they are not detected from a. fischeri. variations of the levels of these products during the incubation of cultures, and also by using different media, are noted. at all events, the toxicity of crude extracts of the mould, for the chick embryo, is ... | 1978 | 375091 |
| aspergillus fumigatus and aspergillus niger in two potted ornamental plants, cactus (epiphyllum truncatum) and clivia (clivia miniata). biological and epidemiological aspects. | the presence and growth of aspergillus fumigatus and aspergillus niger in the soil of ornamental plants have been demonstrated. the ecological conditions in the soil of such plants as influenced by temperature, humidity, desiccation, fertilization and ventilation obviously influence such fungal growth. the epidemiological significance of these findings is of interest with a view to the present efforts to control aspergillosis in the environment of susceptible persons. observations of a preferent ... | 1978 | 375093 |
| humidifier-associated extrinsic allergic alveolitis. | three cases of allergic alveolitis due to indoor humdification systems are described. thermoactinomyces vulgaris precipitins were detected in the serum of a 37-year-old female patient who had typical febrile attacks during exposure to cool-mist from a home humidifier. when the cause was detected and eliminated, the symptoms and signs disappeared and the woman's gas transfer factor improved from 56% to normal within six months. in a printing office a 60-year-old woman had had febrile attacks with ... | 1979 | 375386 |
| characterization of a new choline locus in aspergillus nidulans and its significance for choline metabolism. | 1978 | 376401 | |
| demonstration of antigenemia by radioimmunoassay in rabbits experimentally infected with aspergillus. | antigens were detected in the blood of rabbits infected with aspergillus fumigatus by a solid-phase (tube) radioimmunoassay (ria). the radiolabel for the assay was a polysaccharide-rich alkali extract (apae) from the mycelia of a. fumigatus. before this extract could be suitable labeled with 125i, it had to be conjugated with tyramine. rabbits immunized with heat-killed mycelia had titers of antibody in serum of as high as 1:38,000 against this radiolabeled antigen. with unlabeled and unconjugat ... | 1979 | 376756 |
| allergic bronchopulmonary aspergillosis-like syndrome consequent to aspergilloma. | two patients who represent the first well-documented cases of an allergic bronchopulmonary aspergillosis-like syndrome developing consequent to an aspergilloma are reported. these patients experienced both subjective and objective evidence of improvement after the initiation of corticosteroid therapy. literature relevant to the combined occurrence of aspergilloma and allergic bronchopulmonary aspergillosis and their immunology is reviewed. | 1979 | 378049 |
| identification of a gene for alpha-tubulin in aspergillus nidulans. | 1979 | 378391 | |
| genetic control of transport loss during development of aspergillus nidulans. | 1979 | 378737 | |
| fine-structure mapping of the acetamidase structural gene and its controlling region in aspergillus nidulans. | a large number of amds mutants altered in acetamide utilization have been used to construct a fine-structure map of the amds locus. the mutagen diepoxyoctane generated most of the deletion strains used for mapping. a minimum of 14 sites within the amds gene were found. biochemical analysis of amds mutants defined the extent of the probable coding region. a new mutant, amd-205, which did not produce detectable inactive gene product, was found to be inseparable by recombination from the "up-promot ... | 1979 | 378765 |
| a model for hyphal growth and branching. | a mathematical model for hyphal growth and branching is described which relates cytological events within hyphae to mycelial growth kinetics. essentially the model quantifies qualitative theories of hyphal growth in which it is proposed that vesicles containing wall precursors and/or enzymes required for wall synthesis are generated at a constant rate throughout a mycelium and travel to the tips of hyphae where they fuse with the plasma membrane, liberating their contents into the wall and incre ... | 1979 | 379276 |
| pulmonary infections by the fungus aspergillus. | 1979 | 379325 | |
| [in vivo leukocyte migration in patients with chronic bronchitis and precipitating antibodies to aspergillus fumigatus antigen in the serum]. | 1979 | 380172 | |
| [detection of antibodies against aspergillus fumigatus. 1st report: making of antigens (author's transl)]. | a method of antigen preparation from aspergillus fumigatus has been described. we received the antigens from medium and mycel used for the detection of precipitins and ige-antibodies. the antigenic components are demonstrated in the immunoelectrophoresis. by the use of absorption we did not find essential differences between medium antigen and mycel antigen for the detection of precipitins. the medium antigen recommended for diagnostic is easier to produce and, moreover, has advantages for the d ... | 1979 | 380190 |
| intra- and extracellular forms of alpha-glucosidase from aspergillus niger. | 1979 | 380468 | |
| [substrate thermostabilization of soluble and immobilized glucoamylase]. | a new kinetic approach to the study of enzyme thermal inactivation in the presence of a substrate, which influences the rate of inactivation has been developed. the method was applied to investigation of inactivation kinetics of soluble and porous silica-immobilized glucoamylase. it was found that the binding of a substrate (maltose or maltodextrines star-dri 24-r) increases the thermal stability of glucoamylase, the stabilizing effect being more pronounced in the case of the soluble enzyme (40- ... | 1979 | 380665 |
| rna polymerase from the fungus, aspergillus nidulans. large-scale purification of dna-dependent rna polymerase i (or a). | the dna-dependent rna polymerase i (or a) from the lower eukaryote aspergillus nidulans has been purified on a large scale to apparent homogeneity by homogenizing the fungal hyphae in liquid nitrogen, extraction of the enzyme at high salt concentration, precipitation of rna polymerase activity with polymin p (a polyethylene imine), elution of the rna polymerase from the polymin p precipitate, ammonium sulphate precipitation, molecular sieving on bio-gel a-1.5m, binding to ion-exchangers and dna- ... | 1979 | 380997 |
| [uv-induced dna degradation in aspergillus nidulans cells]. | uv-induced dna degradation was studied in mycellial cells of aspergillus nidulans wild type and several uvs mutants. it was shown to be an enzymatic specific process which possibly reflects the excision of pyrimidine dimers from uv-damaged dna. inhibition of dna degradation by caffeine and 2,4-dinitrophenol shows the connection between degradation and repair of dna. two ways of dna degradation were found in a. nidulans cells, one of them being glucose dependent and the other--glucose independent ... | 1979 | 381100 |
| fungus isolations from sputum. | 1978 | 381527 | |
| aspergillus nidulans as a test organism for assessing radio-induced chromosomal non-disjunction. | a genetically marked heterozygous diploid of aspergillus nidulans was synthesized and the feasibility of using this system for the simultaneous estimation of radio-induced mitotic crossing-over and non-disjunction has been investigated. in the case of the latter, serious experimental problems have been encountered. nevertheless, induction curves for non-disjunction with 15-mev electrons, 50-kvp x-rays, beta-particles and alpha-particles are presented showing an increase in non-disjunction with i ... | 1979 | 381904 |
| comparative susceptibility and effect of mild aspergillus fumigatus infection on three strains of chickens. | a single comb white leghorn strain (dryden x auburn = dax) was more susceptible to aspergillus fumigatus infection and suffered significantly greater mortality than the athens-canadian or a vantress x arbor-acres cross exposed soon after hatching. the unexposed controls of the three types weighed significantly more than the corresponding exposed survivors at 5 weeks of age. | 1979 | 382171 |
| [significance and diagnosis of fungal abortion in cattle]. | 1979 | 382703 | |
| mode of action of the azasteroid antibiotic 15-aza-24 methylene-d-homocholesta-8,14-dien-3 beta-ol in ustilago maydis. | ustilago maydis sporidia treated with 0.1 mug of azasterol (15-aza-24-methylene-d-homocholesta-8,14-dien-3beta-ol) per ml appeared branched and vacuolated after 6 h of incubation. sporidial multiplication, dry weight increase, and synthesis of protein, deoxyribonucleic acid, and ribonucleic acid were only slightly or moderately inhibited during the initial 3 h of incubation. an increase of free fatty acids was observed in lipid extracts of treated sporidia after incubation for 3 h or more. ergos ... | 1979 | 383015 |
| incidence of immediate sensitivity to aspergillus fumigatus in a north american asthmatic population. | allergic bronchopulmonary aspergillosis might be less frequent in north america because the incidence of immediate sensitivity by asthmatics to a. fumigatus is less. in order to check this hypothesis, 200 asthmatics were skin tested with two extracts of a. fumigatus which had been shown to produce positive reactions in fifty patients who had allergic aspergillosis. of the asthmatics, 21.5% reacted to the commercial extract by prick testing and 39% by intradermal testing. using an extract kindly ... | 1979 | 383312 |
| d-galactose requiring mutants in aspergillus nidulans lacking phosphoglucomutase. | 1979 | 383505 | |
| galactomannan antigenemia in invasive aspergillosis. | galactomannan (gm) extracted from mycelia of aspergillus fumigatus with cold dilute alkali reacted with antiserum specific for an antigen that circulated in invasive aspergillosis in rabbits and humans. the gm was purified by its affinity for concanavalin a and was separated from a nonantigenic glucan by gel permeation on sephacryl s-200. the gm molecular weight of between 25,000 to 75,000 was smaller than the antigen present in infected rabbit serum which was retained by an ultrafiltration memb ... | 1979 | 383620 |
| serum ige antibodies in sudden infant death syndrome. | 1979 | 383930 | |
| product induction of purine hydroxylase ii in asperigillus nidulans. | by the use of a mutation, hxb-20, that eliminates purine hydroxylase ii activity but retains cross-reacting material and an ancillary nadh dehydrogenase activity, it has been established that 6-hydroxynicotinic acid rather than nicotinic acid, is the true inducer of purine hydroxylase ii. | 1979 | 384157 |
| do the tightly linked structural genes for nitrate and nitrite reductases in aspergillus nidulans form an operon? evidence from an insertional translocation which separates them. | previous work (rand and arst, 1977) led to the proposal that the nis-5 mutation results in a new low activity promoter for niia, the structural gene for nitrite reductase in aspergillus nidulans. expression of niia via this promoter differs from expression of niia via its normal promoter/initiator in that expression by the new promoter is not subject to nitrate induction or ammonium repression. nis-5 reduces but does not abolish niia expression mediated by the normal promoter/initiator. in this ... | 1979 | 384164 |
| detection of circulating antigen of aspergillus fumigatus in sera of mice and rabbits by enzyme-linked immunosorbent assay. | circulating antigen of aspergillus fumigatus was demonstrated in the sera of experimentally infected, cortisone-treated mice and rabbits by enzyme-linked immunosorbent assay (micro-elisa), confirming earlier results where fungal antigen had been detected by counter-immunoelectrophoresis (cie). peaks of detection of circulating antigen by cie and micro-elisa in mice were not simultaneous suggesting that the nature of the predominant antigens may have altered during the course of infection. cie fa ... | 1979 | 384254 |
| cystic organizing pneumonia with elements of plasma cell granuloma. | 1979 | 384960 | |
| chronic obstructive pulmonary disease (copd) in horses: aetiological studies: responses to intradermal and inhalation antigenic challenge. | micropolyspora faeni and aspergillus fumigatus were identified as common causes of respiratory hypersensitivity in horses affected with chronic obstructive pulmonary disease (copd). rye grass pollen and an actinomycete evoked respiratory allergy in a few horses. not infrequently, individual horses were found to have respiratory hypersensitivity to two or more antigens. the methods used to examine for allergy were intradermal testing and inhalation challenge with environmental antigens. an intrad ... | 1979 | 385306 |
| [fungal maxillary sinusitis]. | since 1969, 600 patients suffering from maxillary sinusitis have been systematically controlled clinically as well as mycologically. we discovered 81 cases of maxillary sinusitis (13,4%). aspergillus fumigatus and candida albicans were the most frequently isolated fungi. three clinical forms could be distinguished: (1) a muco-purulent form (35 cases); (2) a budding and/or caseous form (22 cases), and (3) a pseudotumoral form (24 cases). 42 patients treated with a 1% econazol (base) solution wer ... | 1979 | 385382 |
| [experimental aspergillosis in mice]. | the experimentally induced aspergillosis of mice is discussed as a useful parameter for the screening of new antimycotics. there are important differences between this test model and aspergillus infections in humans. mice must be infected intravenously with more than 10(6) spores of aspergillus fumigatus to provoke multiple abscess formation in the kidneys which induces an acute, lethal course of infection. intratracheal administration of 2 x 10(6) spores did not evoke any symptoms. the therapeu ... | 1979 | 385383 |
| management of pulmonary disorders caused by the inhalation of aspergillus spores. | 1979 | 385573 | |
| [orbital aspergillosis--a contribution to its diagnosis and treatment (author's transl)]. | in connection with a case report, the mycological diagnosis and treatment of orbital aspergillosis are reviewed. in a 59-year-old male patient an exophthalmus on the right side could be diagnosed as aspergillosis spreading from the corresponding sinus maxillaris into retro- and peri-orbicular regions, after other causes had been excluded by differential diagnosis. in a biopsy specimen from the retrobulbar tumor, a fungal granuloma was found which, histologically and by isolation of the fungus, c ... | 1979 | 385968 |
| effect of amphotericin b on the metabolism of aspergillus fumigatus. | action of amphotericin b on the growth and metabolism of aspergillus fumigatus has been investigated. the fungus proved to be very sensitive to amphotericin b, showing complete inhibition of growth at 0.5 units/ml. amphotericin b suppressed the exogenous and endogenous respiration and glycolysis of a. fumigatus as well as the assimilation of various glycolysis and tca cycle intermediates. addition of cations and cholesterol failed to reverse the action of amphotericin b. the treated mycelium rel ... | 1979 | 386128 |
| generalized aspergillosis showing a granulomatous pattern. | an autopsy case of a very rare form of generalized aspergillosis with a prominent granulomatous pattern simulating sarcoidosis was presented. the patient was a forty-year-old japanese female with a four years' clinical course. kveim's test was positive. multiple epithelioid cell granulomata as well as necrotizing and suppurative lesions were recognized in generalized lymph nodes, liver, epicardium, gall bladder, adrenals, kidneys and duodenal mucosa. fungal elements in the epithelioid cell granu ... | 1979 | 386709 |
| effects of fungicides on aspergillus fumigatus. | aspergillus fumigatus was the most frequently isolated thermophilous fungus from green leaf surfaces. the application of fungicides significantly reduced the frequency of its occurrence there. a. fumigatus was relatively tolerant to fungicides. on captan-, thiram-, and verdasan-treated leaves, a. fumigatus constituted 66%--80% of the total number of isolates obtained at 45 degrees c from each treatment while dicloran did not depress the percentages. at 45 degrees c, a. fumigatus was found to be ... | 1979 | 386945 |
| the thermostability of glucoamylase immobilized in different ways has a certain limit. | thermostability of glucoamylase from aspergillus niger is increased both by immobilization and substrate binding. however, the total superimposed stabilization effect at a given condition is apparently restricted by a certain limit which hardly depends on the mode of immobilization of the enzyme, and is determined mostly by the enzyme-substrate complex formation. | 1979 | 387088 |
| analysis of mitotic nondisjunction with aspergillus nidulans. | two methods to detect the induction of nondisjunction with a diploid stable strain of a. nidulans are described. the first method gives only qualitative results, while the second method is quantitative and dose-effect curves can be done. some physiological parameters affecting the induction of nondisjunction can also be studied, because either quiescent or germinating conidia can be treated with the drug under test. some agents inducing nondisjunction were also tested for the induction of point ... | 1979 | 387402 |
| effect of egg-white & avidin on the growth of aspergillus nidulans & on its proteases & nadp-gdh. | 1979 | 387580 | |
| aspergillus in the lung. | there is an increasing incidence of deep mycotic infections. the initial clue to the diagnosis is often radiologic. it is important therefore for the radiologist to be aware of these infections and the setting in which they occur, e.g., allergic bronchopulmonary aspergillosis in the asthmatic person, invasive aspergilliosis in the immune compromised host, and aspergilloma in cavitary lung disease. in so doing he can alert the clinician to the possibility of a mycotic infection and thus initiate ... | 1979 | 387671 |
| mms induction of different types of genetic damage in aspergillus nidulans: a comparative analysis in mutagenesis. | methyl methanesulphonate (mms) was used to test the induction of gene mutation, somatic crossing-over and mitotic non-disjunction in a. nidulans. gene mutation was tested by inducing mutants resistant to 8-azaguanine and revertants of methg1 in a haploid strain. somatic crossing-over was tested in heterozygous diploids, both with a selective method, i.e. inducing homozygosis to fpa resistance in a heterozygous fpa a1/+ strain, and with a non-selective method, i.e. identifying the frequencies of ... | 1979 | 388213 |
| surgical treatment of infective endocarditis. | 1979 | 388517 | |
| [reactivity of peripheral blood granulocytes in aspergillus fumigatus infection]. | 1979 | 388880 | |
| genetic studies of nitrate assimilation in aspergillus nidulans. | 1979 | 389305 | |
| a trial of isolating a tumor-like form of pulmonary cavities infected with aspergilli. ii. intra- and postoperative, morphologic and serologic data. | in ten specimens of resected pulmonary tissue, a little known and underscribed form of aspergillosis called tumor-like blocked pulmonary cavity with liquid content infected with aspergilli was observed. this designation was based on the finding in the specimens of tumor-like cavitary structures with blocked bronchus and contents from which abundant growth of aspergillus fumigatus was invariably obtained in cultures. nine of the ten specimens were bronchiectasis, and one was a bronchogenic cyst. ... | 1978 | 389368 |
| invasive aspergillosis presenting as pericarditis and cardiac tamponade. | a 38-year-old leukemic patient developed pericarditis and cardiac tamponade due to aspergillus niger one month after undergoing bone marrow transplantation. she failed to improve even though amphotericin b and rifampin therapy had been initiated before infection was evident. her unique case illustrates both the unusual presentations of invasive aspergillosis and the difficulty of diagnosing and treating this increasingly common disease. | 1979 | 389577 |
| reaction of beta-d-glucosidase a3 from aspergillus wentii with d-glucal. | 1979 | 389631 | |
| deletion mapping of the niia niad gene region of aspergillus nidulans. | 1979 | 389740 | |
| antibiotic properties of lignin components. | inhibitory effects of compounds with guaiacyl and syringyl structure, representing the structure of native lignin, were studied on model cultures of bacteria, yeasts, yeast-like microorganisms and moulds. isoeugenol exhibited the most pronounced inhibitory effect on growth of the studied microorganisms. | 1979 | 389763 |
| recurrent mutation and selection for increased penicillin titre in aspergillus nidulans. | recurrent mutation and selection has been used to increase penicillin titre in two closely related strains of aspergillus nidulans. a selection programme was initiated from each of the two strains (programmes a and b) and continued through six cycles of mutation and selection. near-ultraviolet light in conjuction with 8-methoxypsoralen was employed as the sole mutagen throughout programme a and ethyl methanesulphonate as the sole mutagen throughout programme b. excluding the first cycle of a, wh ... | 1979 | 390092 |
| mutagens in coffee and tea. | coffee prepared in the usual way for drinking contains a substance(s) that is mutagenic to salmonella typhimurium ta100 without mammalian microsomal enzymes. one cup of coffee (200 ml) contains mutagen(s) inducing 1.4-4.6 x 10(5) revertants under standard conditions. instant coffee too is mutagenic to ta100 and one cup of instant coffee prepared from 1 g of coffee powder and 200 ml of water induced 5.6-5.8 x 10(4) revertants of ta100. caffeine-free instant coffee also has similar mutagenicity. a ... | 1979 | 390384 |
| mutational studies with diquat and paraquat in vitro. | diquat and paraquat were assayed in the following tests. (1) ames test in salmonella typhimurium (strains ta1535, ta1537, ta1538, ta98 and ta100) with and without rat-liver microsomal fractions. (2) resistance to 8-azaguanine in salmonella typhimurium (strain hisg46, ta92 and ta1535. (3) repair test in salmonella typhimurium (strains ta1538 and ta1978). (4) gene mutations in aspergillus nidulans: 8-ag resistance and methionine suppression (meth a1 locus). (5) lethal recessive damage in aspergill ... | 1979 | 390391 |
| [aspergillosis of the nose and paranasal sinuses]. | 1979 | 390917 | |
| intradural extramedullary aspergilloma complicating chronic lymphatic leukaemia. | 1979 | 391317 | |
| [changes in rabbit lungs after exposure to grain and hay dust and in intravenous injections of aspergillus niger and candida albicans (author's transl)]. | 1979 | 391392 | |
| response to bronchial provocation and exercise in children with cystic fibrosis. | ten of fifteen cystic fibrosis children with positive skin prick tests to common antigens gave an immediate bronchial reaction to the antigen inhaled, five of them also gave a late reaction; however only one gave a history of asthma. the antigen most commonly eliciting a positive skin reaction in cystic fibrosis patients is aspergillus fumigatus. in six children tested to this antigen the bronchial response varied, two were negative, one gave an immediate reaction and three gave a dual (immediat ... | 1979 | 391435 |
| [a fungistatic effect of some aliphatic amines (author's transl)]. | 1979 | 392321 |