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natural history of rickettsia rickettsii. 19863096192
cloned gene of rickettsia rickettsii surface antigen: candidate vaccine for rocky mountain spotted fever.two major protective antigens of rickettsia rickettsii have been previously described. in this study, we cloned the gene encoding one of these antigens into escherichia coli and tested the effectiveness of the recombinant-made product as a vaccine for rocky mountain spotted fever. a clone bank of r strain r. rickettsii dna was made in e. coli k-12 by using the plasmid vector pbr322. transformants were screened for their ability to make rickettsial antigens by reactivity with rabbit antibodies to ...19873099387
fluvoxamine in the treatment of the older depressed patient; double-blind, placebo-controlled data.fluvoxamine was given in placebo-controlled trials to 33 severely depressed patients of between 60 and 71 years, 29 received imipramine and 14 placebo. at week 4 of treatment fluvoxamine and imipramine were superior to placebo on the hamd and cgi scales (p less than 0.05). there was indication of an earlier onset of antidepressant activity in the fluvoxamine group. there was no evidence of systematic changes in laboratory variables in any treatment group. fluvoxamine and placebo had similar effe ...20113104446
in vitro antibiotic susceptibility of rickettsia rickettsii and rickettsia conorii: plaque assay and microplaque colorimetric assay. 19873104481
susceptibility of rickettsia conorii and r. rickettsii to pefloxacin, in vitro and in ovo.the activity of pefloxacin against rickettsia conorii and r. rickettsii was determined by several methods. the mean survival time of embryonated eggs infected with r. conorii was increased by pefloxacin 50 micrograms/egg; plaque formation in vero cells was inhibited by 1 mg/l. in a microplate assay, the mic of pefloxacin was 0.5 mg/l for r. conorii and 1 mg/l for r. rickettsii. the results support the use of pefloxacin in treating spotted fever rickettsioses.19873106303
a serological survey of scrub, tick, and endemic typhus in sabah, east malaysia.a seroepidemiological survey of 837 people and 383 febrile patients was performed in rural areas of sabah. we determined that the rickettsial diseases scrub typhus and endemic typhus were uncommon causes of febrile illness, as was tick typhus, except in forest dwelling peoples. the rate of occurrence of sfgr specific antibody was 16.5% among 412 forest dwellers, indicating that tick typhus may be a frequent cause of illness in this population.19863107139
sequence analysis of the 17-kilodalton-antigen gene from rickettsia rickettsii.dna obtained from the sheila smith strain of rickettsia rickettsii was digested to completion with the restriction endonucleases bamhi and sali and ligated with the plasmid vector puc19. the ligation mixture was used to transform escherichia coli. a total of 465 bacterial clones were screened for antigen production with hyperimmune rabbit serum. one of the reactive clones, containing a recombinant plasmid designated pss124, was solubilized and subjected to immunoblot analysis and revealed expres ...19873108232
[description of a treatment technic using a co2 laser in a lymphangioma of the upper aerodigestive tract]. 20113109273
steroid production in vitro by granulosa, theca, and luteal cells from goat ovaries.basal progesterone (p4) production by isolated goat ovarian cells in vitro was in the order corpus luteum (cl) greater than granulosa (g) greater than theca (th), while estradiol (e2) production was in the order th greater than g greater than cl. in g cells, various concentrations (0.01 to 100 micrograms/ml) of luteinizing hormone (lh), human chorionic gonadotropin (hcg) and follicle-stimulating hormone (fsh) increased p4 and e2 secretion. testosterone (t, 10(-9) to 10(-5) m) produced dose-depen ...19873109512
psychiatric expertise in clinical decision making for psychiatric inpatients.hospital boards and medical staffs are faced with difficult decisions about whether nonphysician mental health professionals should be given admitting privileges to psychiatric hospitals or treatment units. the authors describe the special medical expertise of the psychiatrist and define 11 indicators, such as a patient's need for new psychotropic medication or the presence of symptoms requiring medical or laboratory procedures, that can be used to determine whether psychiatric expertise is need ...20093111970
psychiatric expertise in clinical decision making for psychiatric inpatients.hospital boards and medical staffs are faced with difficult decisions about whether nonphysician mental health professionals should be given admitting privileges to psychiatric hospitals or treatment units. the authors describe the special medical expertise of the psychiatrist and define 11 indicators, such as a patient's need for new psychotropic medication or the presence of symptoms requiring medical or laboratory procedures, that can be used to determine whether psychiatric expertise is need ...20093111970
cytological characteristics of main cellular elements in benign and malignant giant cell tumor of bone. 20113115731
antibodies to spotted fever-group rickettsiae in dogs in north carolina.a seroepidemiologic survey was conducted to determine the prevalence of antibodies reactive with 4 spotted fever-group (sfg) rickettsiae in sera of dogs from various geographic regions in north carolina. serum specimens were obtained from 600 dogs, and antibody titers were determined, using microimmunofluorescence. data analysis (setting as the criterion for a positive result, a rickettsia rickettsii titer greater than or equal to 1:64) overestimated the actual prevalence of canine exposure to t ...19873118744
infection and injury of human endothelial cells by rickettsia rickettsii. 19863122642
clinical, hematologic, and humoral immune response in female dogs inoculated with rickettsia rickettsii and rickettsia montana.female beagles were inoculated intradermally with a sublethal dose of rickettsia rickettsii and r montana. three dogs (group 1) were inoculated with 2 x 10(2) plaque-forming units (pfu) of r rickettsia and were treated with tetracycline beginning on postinoculation day (pid) 12; 3 dogs (group 2) were inoculated with 2 x 10(2) pfu of r rickettsii but were not treated; 3 dogs (group 3) were inoculated with 2 x 10(2) pfu of r montana. group-3 dogs failed to seroconvert and were inoculated a second ...19883128147
limited proteolysis of bovine adrenodoxin reductase: evidence for a domain structure.treatment of bovine adrenodoxin reductase with trypsin under conditions of limited proteolysis yields two major fragments of apparent molecular weights 30,500 and 20,200. the fragments, which have been partially purified by affinity chromatography to remove most of the intact adrenodoxin reductase, retain adrenodoxin-dependent nadph cytochrome c reductase activity. kinetic analyses yield vmax and km (adrenodoxin) values of 485 min-1 and 0.96 microm, respectively, at an ionic strength of 0.13 m i ...19883128975
update: acquired immunodeficiency syndrome (aids)--worldwide.as of march 21, 1988, 136 countries or territories throughout the world had reported a total of 84,256 cases of aids to the global programme on aids (gpa) (formerly the special programme on aids) of the world health organization (who). 37 countries or territories had reported no aids cases. reports are based on either the centers for disease control (cdc)/who surveillance definition, the who clinical definition, or a physician's diagnosis. from 1979 through march 21, 1988, the number of aids cas ...20113129644
[experimental chemo- and chemoendocrine therapy of human breast carcinomas serially transplanted into nude mice].four human breast carcinoma strains serially transplanted into nude mice were used for the experimental chemotherapy and combination chemoendocrine therapy. whereas three of these strains (mcf-7, br-10, tm-61) possessed cytosol estrogen receptor (erc) and were dependent on estradiol for the tumor growth, the other strain (mx-1) without erc was hormone independent. for the chemotherapy, mitomycin c (mmc), adriamycin (adm), cyclophosphamide (cpm) and 5-fluorouracil (5-fu) were administered 3 times ...19883129645
in vitro evaluation of josamycin, spiramycin, and erythromycin against rickettsia rickettsii and r. conorii.the antimicrobial activities of josamycin, erythromycin, and spiramycin against rickettsia conorii and r. rickettsii were evaluated in two tests: a dye-uptake assay and a plaque assay. the mic of josamycin was 1 microgram/ml for both species; the mics of erythromycin and spiramycin were 4 to 8 and 16 to 32 micrograms/ml, respectively, for both species. only josamycin may be of clinical use in treating spotted fever rickettsiosis. it may be useful in treating pregnant women and young children.19883129987
a focus of rocky mountain spotted fever within new york city.in the spring and summer of 1987, four persons acquired rocky mountain spotted fever within new york city, an area in which the disease had not previously been known to be endemic. three of the four patients were residents of the soundview area of the bronx. all diagnoses were confirmed by indirect fluorescent-antibody tests. environmental investigation revealed that the tick vector for rickettsia rickettsii, dermacentor variabilis, was present in a local park. of the 66 specimens of d. variabil ...19883130574
protection of guinea pigs from experimental rocky mountain spotted fever with a cloned antigen of rickettsia rickettsii. 19883134494
segregation analysis of juvenile myoclonic epilepsy.we examined the inheritance of juvenile myoclonic epilepsy (jme). we looked at both the trait of "epilepsy" and the trait of "epilepsy-plus-eeg abnormalities," since eeg abnormalities are frequently found in the clinically unaffected sibs of jme patients. we tested several modes of inheritance including the fully penetrant recessive and several two-locus models. we could reject all models tested (fully penetrant single-locus and two-locus models) when abnormal eegs were classified as "unaffected ...20103136050
tripelennamine enhances buprenorphine-, but not pentazocine-induced hyperactivity in mice.the opioid agonist-antagonist pentazocine (1-30 mg/kg) and the partial agonist buprenorphine (0.05-0.25 mg/kg) were tested, alone or in combination with the histamine h1-receptor antagonist tripelennamine (1, 2.5, 5 or 10 mg/kg), on locomotor activity in mice of the cd-1 strain. when given alone, pentazocine produced slight and non-dose-related activity increments, while buprenorphine induced strong and dose-related locomotor stimulation. tripelennamine slightly increased activity by itself and ...20113137594
serological examinations of slaughtered animals (cattle and goats) in the slaughter-house of colombo/sri lanka towards antibodies against brucellosis, q-fever, rmsf-rickettsia-group, listeriosis, echinococcosis and adenoviruses.serological examinations of slaughtered animals (76 cattle and 184 goats) in the slaughter-house of colombo/sri lanka revealed antibodies against listeriosis, brucellosis, q-fever, rmsf-rickettsia-group, echinococcus and adenoviruses. as the results show, part of this zooanthroponosis has a role to play in human medicine and human infections are to be expected.19883139493
expression of the gene encoding the 17-kilodalton antigen from rickettsia rickettsii: transcription and posttranslational modification.recently, we reported the molecular cloning and nucleotide sequence analysis of a gene from rickettsia rickettsii that codes for a 17-kilodalton antigen (17k antigen) and is preceded by sequences closely resembling the -10 and -35 consensus sequences for recognition by escherichia coli rna polymerase (anderson et al., j. bacteriol. 169:2385-2390, 1987). experiments described in this report indicate that the start sites for initiating transcription of the 17k antigen gene are identical in the e. ...19883139629
ovarian carcinoma: abdominopelvic irradiation following reexploration.twenty patients with ovarian cancer, who following reexploration were left with residual disease nodules of less than 2 cm diameter, received abdominopelvic irradiation. of these patients 18 had previous chemotherapy. fifteen patients completed treatment, 13 of whom had prior chemotherapy. six of the 18 patients with invasive tumors were alive and disease free 18-53 months postradiotherapy, while only 4 patients had died at the time of follow-up. no patient with residual nodules greater than 1 c ...20113141249
potential for free radical-induced lipid peroxidation as a cause of endothelial cell injury in rocky mountain spotted fever.cells infected by rickettsia rickettsii, the causative agent of rocky mountain spotted fever, display unusual intracellular morphological changes characterized by dilatation of the membranes of the endoplasmic reticulum and outer nuclear envelope. these changes are consistent with those that might be expected to occur following peroxidation of membrane lipids initiated by oxygen radical species, such as the hydroxyl radical or a variety of organic radicals. using a fluorescent probe, we have fou ...19883141280
extraction of protective components of rickettsia rickettsii with n-octyl-beta-d-glucopyranoside.two rickettsia rickettsii proteins, with apparent molecular masses of 120 and 155 kilodaltons, have been implicated as important antigens in immunity to rocky mountain spotted fever. an n-octyl-beta-d-glucopyranoside-soluble fraction of r. rickettsii was found to be enriched for these proteins along with others. vaccination of mice with the detergent-soluble fraction protected them against death caused by r. rickettsii and protected guinea pigs from developing rocky mountain spotted fever after ...19883142019
antibodies to ehrlichia canis, ehrlichia platys, and spotted fever group rickettsiae in louisiana dogs.antibodies to ehrlichia canis, ehrlichia platys, and spotted fever group (sfg) rickettsiae were detected by indirect immunofluorescence in sera from 27 ill individually owned thrombocytopenic dogs (platelet concentrations less than 200,000 platelets/microliters) and 59 healthy kenneled dogs located in southern louisiana. platelet concentrations less than 100,000 platelets/microliters were detected in 63% of ill thrombocytopenic dogs and 6.8% of healthy kennel dogs. one ill thrombocytopenic dog h ...19883146636
report of the second public health service aids prevention and control conference. women and aids. 20113147491
the population dynamics of two vertically transmitted infections.the transmission of keystone virus in the mosquito aedes atlanticus and of rickettsia rickettsii in the tick dermacentor andersoni is modeled and analyzed. both of these infections can be transmitted vertically from an infective parent to newborn offspring as well as horizontally via direct or indirect contacts with infected individuals. the vertical transmission mechanism plays a major role in the maintenance of these infections and its effects are analyzed in detail. this same mechanism can ac ...19883148206
creatinine excretion rates for evaluation of kidney function in children.a protein load protocol for evaluation of kidney function was tested in normal children and pediatric renal patients. an overnight, timed urine collection was used for calculation of the baseline creatinine clearance and creatinine excretion rate. one hour following ingestion of a standardized protein meal (baked chicken), a 2-3 h urine collection was begun. the post-protein meal changes in creatinine clearance showed considerable variation in both the normal children and those with renal disord ...19883153054
re: general practitioners and orthodontics. 20113162643
clinical alternative. formulating your own concept of occlusion. 20113163180
the elastogenic effect of recombinant transforming growth factor-beta on porcine aortic smooth muscle cells.transforming growth factor-beta, a peptide growth factor, is known to be a multifunctional regulator of cellular activity. the effect of this growth factor on extracellular matrix formation is well established, but its effects on elastin, a critical component of lung, skin, and blood vessels are unknown. in the present study, by use of an enzyme-linked immunoassay method, we found that transforming growth factor-beta strongly increased elastin production in cultured porcine aortic smooth muscle ...19883165637
antibacterial action of powdered semiconductor on a serotype g streptococcus mutans (short communication). 19883165714
a new approach to the quality control of steroid receptor assays.lyophilized cytosols prepared from calf uterus and human breast tumor tissue are commonly used to assess the reliability of routine steroid receptor assays. however, preanalytical error (sample preparation, storage, homogenization) cannot be detected in this way. participating laboratories were asked to mail us all their receptor results obtained over a four-month interval, and to include some information about the patients involved (age, menopausal status, nodal status). after verifying the hom ...19883168219
interactions of age, gender, and sensorineural hearing loss on abr latency.the interactive effects of gender, age, and degree of sensorineural hearing loss on the absolute latency of wave v of the auditory brain stem response were analyzed in 325 subjects with cochlear loss. norms based on these data were then applied to an analysis of the wave v latencies of 87 subjects with retrocochlear loss. results in the cochlear group revealed interactions between gender and age and between gender and degree of hearing loss. the interactive effect between gender and degree of lo ...20113169397
use of oblique chest roentgenograms in detecting pleural disease in asbestos-exposed workers.oblique chest roentgenograms have been recommended by some for use in screening programs of asbestos-exposed workers to increase detection of pleural fibrosis not evident on posteroanterior (pa) films. as a screening test, identification of pleural abnormalities with oblique films is especially important in subjects without evidence of other asbestos-induced abnormalities on pa films, namely, parenchymal fibrosis. to evaluate the incremental value of oblique films in the identification of pleura ...20113183783
[hyperuricemia in the joint syndrome in children]. 20113186400
[basic knowledge of electrocardiography]. 20113187347
separation and identification of trifluralin metabolites by open-tubular liquid chromatography/negative chemical ionization mass spectrometry.the utility of combined open-tubular liquid chromatography/negative ion chemical ionization (nci) mass spectrometry for the separation and analysis of trifluralin, a commonly used pre-emergence herbicide, and seven of its metabolites has been demonstrated. the nci mass spectra for these compounds are reported. some of the nci mass spectra were obtained from as little as 50 pg of analyte.20113203148
[an experience of a nursing instructor as a patient. 8. suffering imposed on the patient (2): problems related to treatment]. 20113204763
[esophagectomy via a right-sided thoracic approach. role of the circulating nurse]. 20113206015
[specificity of first and second generation hiv-1 antibody screening tests].among 9867 sera tested between january and april 1987 by abbott htlv-iii eia (cell culture-derived antigen) 155 reacted repeatedly positive. 22% of these could not be confirmed, while 77% could be confirmed by other tests. the results of 2 sera remained equivocal. subsequently abbott recombinant htlv-iii eia was used and until august of the same year 184 out of 11508 sera gave reproducible positive results. 12% of these could not be confirmed, while 86% could be confirmed. the results of 3 sera ...19883209234
perforations of the tympanic membrane following the use of goode-type 'long term' tympanostomy tubes.a retrospective review of 64 goode 't' tube insertions is presented. these were inserted into 61 ears of 48 patients over a period of four years. at the time of review of these 61 ears, 34 tubes were found to be in situ, 27 had extruded spontaneously and three had been removed surgically. ten ears in which the tube had been extruded or removed had central perforations of the tympanic membrane of which eight had been present for more than six months. the number of previous myringotomies or gromme ...20113209952
serum free thyroxine and free tri-iodothyronine in normal children.serum free thyroxine (ft4) and free tri-iodothyronine (ft3) were measured in 138 normal school children, adolescents and their younger siblings, whose ages ranged from 3 months to 18 years. mean ft4 concentration (16.8 pmol/l) was similar to the adult mean concentration of 17 pmol/l and all the values were within the adult reference range. at all ages the ft3 range was considerably higher than the adult reference range and the overall mean ft3 concentration (8.3 pmol/l) was at the upper limit of ...20113232955
hazardous waste minimization: part ix. waste minimization in the automotive repair industry. 20113236044
[consequences of the composition of breast milk for the nutrition of underweight newborn infants. i. calcium and phosphorus]. 19883236663
[disappearance of a calcification of the sub-quadriceps pouch in a case of chondrocalcinosis]. 20113245685
[treatment of chronic bursitis with fistula by a cryogenic method]. 20123247124
pediatric emergency care: a survey of michigan emergency departments. 20113250954
[gonorrhea, chlamydia infection, trichomonas vaginitis and candidiasis in drug addicts. second report]. 19883253803
spatial phase dependence and the role of motion detection in monocular and dichoptic forward masking.contrast thresholds for briefly flashed gratings were measured by the quest procedure, under conditions of forward masking by gratings of the same spatial frequency (usually 1 c/deg). low-contrast masks reduced threshold at short onset asynchronies (0 to 50 msec), while higher contrasts raised threshold over a broader temporal range (0 to 100-140 msec). both effects depended on the spatial phase relation, but in different ways. threshold reduction at 0- +/- 90 deg phases probably arises from spa ...20113253991
spatial phase dependence and the role of motion detection in monocular and dichoptic forward masking.contrast thresholds for briefly flashed gratings were measured by the quest procedure, under conditions of forward masking by gratings of the same spatial frequency (usually 1 c/deg). low-contrast masks reduced threshold at short onset asynchronies (0 to 50 msec), while higher contrasts raised threshold over a broader temporal range (0 to 100-140 msec). both effects depended on the spatial phase relation, but in different ways. threshold reduction at 0- +/- 90 deg phases probably arises from spa ...20113253991
the role of trimethoprim/sulfamethoxazole in the treatment of wegener's granulomatosis. 20123261588
[visual function and the preparation for employment of persons with congenital glaucoma. v. preparation for working employment]. 20123267756
[ectopic parathyroid adenoma disclosed by cortical blindness and hypercalcemic encephalopathy]. 20123269289
rocky mountain spotted fever.the epidemiology, pathogenesis, clinical features, and treatment of rocky mountain spotted fever are reviewed. rocky mountain spotted fever is a severe infection caused by rickettsia rickettsii transmitted to man by various species of ticks. high-incidence areas exist in the southeast and south central united states. only 60-70% of patients with the disease report a history of tick bite or exposure to tick-infested areas. the disease is initially characterized by fever, headache, gastrointestina ...19883280217
ventricular arrhythmias.sudden cardiac death claims thousands of canadians annually. ventricular tachycardia and fibrillation account for up to 85% of these deaths. identifying the patients at risk remains a major challenge. those who have recurrent ventricular tachycardia or have been resuscitated from ventricular fibrillation are generally considered to be at highest risk. although ventricular premature beats in the absence of previous ventricular tachycardia or fibrillation are not helpful in identifying such patien ...20123284626
[immunodiagnosis of aids using preparations of the recombinant antigen of the surface protein of the htlv-iii virus].a technological scheme has been developed for purification of recombinant antigen of surface protein (asp) of the causative virus of aids from escherichia coli cells carrying plasmid pl2 which codes for the synthesis of a hybrid polypeptide consisting of phage lambda n protein (59 amino acid residues) and a fragment of sp (env) of hiv virus (569 a.r.). purification of asp is based on two separation principles: fractionation of polypeptides of bacterial lysates by preparative isoelectrofocusing i ...19883285593
traumatic endophthalmitis. 20063294703
vasoactive intestinal polypeptide immunoreactive neurons in the primary visual cortex of the cat.when cat visual cortex (area 17) is reacted with an antibody to vasoactive intestinal polypeptide (vip) a variety of neuronal types is labelled. many of the labelled neurons are bipolar in form and are most common in layers ii and iii, although significant numbers of bipolar neurons are also encountered in layer v. multipolar cells are also labelled. these are most frequent in layer iv and have a variety of shapes. in layer i, the labelled cells are of three varieties, i.e. horizontal bipolar ce ...19873295123
subfractionation of the dansylated derivatives of glucosyl galactosyl hydroxylysine by liquid chromatography and its application to a specific alpha-1,2-glucosidase assay.the dansyl derivative of glucosyl galactosyl hydroxylysine (ggh) was separated into two components, as gp-i (monodansyl ggh) and gp-ii (didansyl ggh) by paper chromatography. gp-i was further fractionated into four peaks (a, b, c and d) by reversed-phase liquid chromatography. these peaks corresponded to the dansyl derivatives at the alpha-amino (a and b) and epsilon-amino (c and d) groups of their hydroxylysine residues. there is the possibility that the fractions for b and d are diastereoisome ...19873298291
the role of intravenous digital subtraction angiography as an adjunct to computed tomography in the preoperative assessment of patients with abdominal aortic aneurysm.the purpose of this article is to determine the role of intravenous digital subtraction angiography (iv-dsa) as an adjunct to computed tomography (ct) in the preoperative evaluation of patients with abdominal aortic aneurysm. sixty-six patients underwent iv-dsa as well as ct during a 2-year period. sixty-four of the 66 patients underwent abdominal aortic aneurysm repair. the results of the 66 patients were analyzed to assess what additional information was obtained by iv-dsa concerning aneurysm ...20123298699
[etiopathogenesis of diabetes mellitus]. 20123299516
phenotypic composition and in vitro functional capacities of unmodified fresh cells infiltrating acutely rejected human kidney allografts.cell surface markers of isolated graft-infiltrating cells (gic) were studied, and functional in vitro assays performed in 8 cases of acute irreversible rejection of human renal allografts. the gic were mostly activated t cells (okt11+, okt3+, ia+), with predominance of the cytotoxic/suppressor t cell phenotype (okt8+). a small proportion of b cells and monocytes/macrophages were also present among these gic. the gic were able to proliferate with lectin of allogeneic stimulation and were strongly ...19873299920
[myelography and computerized tomography in the diagnosis of spinal cord compression in children]. 20123302968
[a case of successful transplantation of allogeneic bone marrow in a patient with myelocytic leukemia].allogenic bone marrow transplantation was performed in a patient with chronic myelocytic leukemia (ph+) in a stable phase. a 1,5-year recurrence-free period since the time of transplantation was observed. transplantation features were as follows: incompatibility of the recipient and donor by abo-antigens, the development of acute graft versus host disease and transient ph-positivity.20123307011
piroximone (mdl 19,205) in the treatment of unstable and stable chronic cardiac failure.the hemodynamic and clinical response to oral and intravenous piroximone was examined in 25 patients with chronic cardiac failure secondary to ischemic or myopathic heart disease: 14 with severe failure, who were clinically unstable (group i), and 11 with stable failure of mild to moderate severity (group ii) in whom maximal o2 uptake (vo2 max) to treadmill exercise could be monitored serially. intravenous (0.5 to 1.0 mg/kg) and oral (0.7 to 4.9 mg/kg) piroximone significantly (p less than 0.05) ...20113310566
mixed hematopoietic chimerism following bone marrow transplantation for hematologic malignancies.twenty-nine of 172 patients (17%) who received an allogeneic bone marrow transplant (bmt) from histocompatible sibling donors for hematologic malignancies were mixed hematopoietic chimeras; ie, they had a mixture of donor and host hematopoietic or lymphohematopoietic cells at greater than or equal to 14 days after transplantation. twenty-four of the 29 mixed chimeras (83%) have remained in continuous complete remission for up to 116 months (greater than 9 years) following bmt. four of the 29 pat ...20113311201
a human teratocarcinoma which expresses a rare neuronal cell surface antigen.a molecular characterization of the events at the cell surface of neurons is pivotal for our understanding of how the nervous system is formed and maintained. this study of cell surface events in the human nervous system may be crucial to the study of human neurological maladies. ntera-2 is a human teratocarcinoma which is unique amongst the teratocarcinomas for its ability to express many neurons. tested for the binding of a monoclonal antibody tor 23, which recognizes a surface antigen on rare ...19873315107
antibodies against mammary derived growth inhibitor (mdgi) react with a fibroblast growth inhibitor and with heart fatty acid binding protein.a polypeptide growth inhibitor, designated as mammary derived growth inhibitor, has previously been purified from lactating bovine mammary glands. polyclonal rabbit antiserum raised against mammary derived growth inhibitor cross-reacts with bovine heart fatty acid binding protein and bovine peripheral myelin p2 protein. these results are consistent with the observation that the amino acid sequence of mammary derived growth inhibitor showed homology to the sequences of these proteins. in a parall ...19873318832
hormones in milk. 19873320320
[a case report of portal-systemic encephalopathy with normal portal vein pressure and non-cirrhosis of the liver]. 20043320417
[the problems of cardiovascular pathology in adolescents]. 20053320454
[development of l.v. gromashevskiÄ­'s theory within the socio-ecological concept of the epidemiological process]. 20113321777
[l.v. gromashevskiÄ­'s paradigm]. 20113321779
[renin-angiotensin-aldosterone system in hypertension patients who have had a cerebral stroke].the study of the renin activity and aldosterone concentrations in the blood plasma has revealed activation of the renin-angiotensin-aldosterone system (raas) in patients with stage iii essential hypertension and a history of 1-3-year-old cerebral stroke. middle-aged patients demonstrated high activity of renin and high levels of aldosterone whereas elderly patients presented a moderate rise in renin activity and elevated aldosterone levels. the data obtained indicate a decrease in the endocrine ...20113321797
insulin resistance and abnormal ovarian responses to human chorionic gonadotropin in chronically anovulatory women.we studied the interrelationships between insulin resistance, obesity, and abnormal ovarian androgen secretion in chronically anovulatory women with clinical or biochemical evidence of hyperandrogenism. four groups of six subjects each were studied: (1) normal weight (within 10% ideal body weight) anovulatory, (2) obese (greater than 120% ideal body weight) anovulatory, (3) normal weight eumenorrheic, and (4) obese eumenorrheic. after dexamethasone suppression, human chorionic gonadotropin (2000 ...19873322017
connective tissue responses in blacks in relation to disease: further observations.additional information is presented in support of the hypothesis (polednak: am. j. phys. anthropol. 41:49-58, 1974) that in some black populations certain connective-tissue responses, which are involved in protection against infection and repair after injury, also may predispose to specific chronic diseases. these diseases include some autoimmune disorders (i.e., systemic lupus erythematosus, sarcoidosis, and scleroderma) and various benign and malignant tumors involving connective-tissue cells. ...20103322033
effect of intestinal factors on extraction of insulin in perfused rat liver.to study the direct effect of intestinal factors on hepatic extraction of insulin, an investigation was made into the extraction of insulin from isolated rat liver perfused with portal venous effluent (pve) obtained from the isolated perfused rat intestine. rat intestine was perfused with krebs-ringer bicarbonate medium for 45 min, and the pve was collected from glucose-, lipid-, or nacl-treated and untreated control intestines. the pve, after adjustment of its glucose (180 mg/dl) and insulin (2 ...19873322037
theory and development of transcutaneous oxygen pressure measurement. 20043323065
[effect of anaprilin on the clinical course of stenocardia and the carbohydrate metabolic indices of ischemic heart disease patients in relation to the nature of their glucose tolerance].fourteen-day anaprilin treatment of coronary patients with varying glucose tolerance has demonstrated that the drug's therapeutic efficiency was greater in patients with normal glucose tolerance. anaprilin caused a moderate drop in baseline glucose level and considerably limited the degree of hyperglycemia in response to the glucose tolerance test in coronary patients with abnormally low glucose tolerance. insulin content was virtually unaffected by the drug, irrespective of the type of glucose ...19913327995
essential thrombocythemia in pregnancy.a 32-year-old women with essential thrombocythemia and a history of bleeding completed a full-term pregnancy. during pregnancy, the platelet count declined markedly to near-normal levels, but returned to prepregnancy levels within two weeks after delivery. the clinical course was uneventful, except for two brief episodes of vaginal bleeding during the second trimester. possible etiologic mechanisms for pregnancy-related reduction of platelet levels in thrombocythemia include increased platelet c ...20123347444
hematology, intestinal parasites, and selected disease antibodies from a population of bobcats (felis rufus) in central arkansas.eight bobcats with adjoining or overlapping home ranges were examined. hematological values were within previously reported ranges. six bobcats demonstrated antibody titers to toxoplasma gondii. isospora spp., taenia taeniaeformis, spirometra mansoides, physoloptera rara, toxocara cati, strongyloides spp., trichurus spp., capillaria spp., and ancyclostoma spp. were found also in the animals examined. the mean number of parasite species per host was 4.1. all bobcats tested negative for serum anti ...19883352091
nurses helping nurses. 20123358078
geriatric education: training and practice perspectives. 20103358111
hypophosphatemia-associated respiratory muscle weakness in a general inpatient population.although hypophosphatemia has been implicated as a cause of respiratory failure, its impact on respiratory muscle function in patients hospitalized for other reasons remains to be determined. maximal inspiratory pressures (mip) and maximal expiratory pressures (mep) were measured at the bedside in 23 hospitalized patients with serum phosphate levels less than 2.5 mg/dl, and these measurements were repeated daily during phosphate repletion until serum phosphate levels reached the normal range. a ...20123364446
autosomal recessive inheritance of nager acrofacial dysostosis.nager acrofacial dysostosis is a variant of mandibulofacial dysostosis with severe micrognathia, malar hypoplasia, and radial limb defects. most cases are sporadic, but autosomal recessive inheritance has been suggested. a family is reported in which two sibs are affected by this syndrome, presenting further evidence for autosomal recessive inheritance. the recognition of this syndrome as a distinct entity has important implications. after the birth of a child with orofacial malformations sugges ...20053367347
anion transport during maturation of erythroblastic cells.bromide uptake was measured in single maturing erythroblastic cells of rabbits by means of x-ray microanalysis. increase in bromide uptake as the cells matured was observed. the order of cells from low to high bromide uptake was: early erythroblast less than late erythroblast less than marrow red cells less than peripheral red blood cells. the transition from low to high bromide uptake is correlated to the accumulation of iron which begins in the late erythroblast. a decrease in rubidium uptake ...19883367365
assess the workplace. 20023369764
activity level in hospitalized children during sleep onset latency. 20123370525
bowenoid papulosis of the penis: successful management with neodymium:yag laser.bowenoid papulosis of the penis is a recently described entity that clinically resembles benign verruca-like papular lesions but, histologically, it is identical to carcinoma in situ, bowen's disease or erythroplasia of queyrat. although a few cases of spontaneous regression of bowenoid papulosis in men have been reported, conservative therapy, consisting of topical 5-fluorouracil, electrodissection or excision, is recommended. with these treatment modalities recurrences are not uncommon. we rep ...20123373609
beef and chocolate: a partial reprieve. 19883375809
[effect of acute and chronic administration of melatonin on the temporal dynamics of apomorphine-induced stereotypy].melatonin (1-20 mg/kg) weakened in a dose-dependent way the intensity degree of apomorphine-induced stereotypy in rats. according to the spectral analysis data, this is followed by an increase of the number of waves with a short (2-3 per min) period in the temporal structure of stereotypy recorded every one minute. after administration of melatonin (1 mg/kg), the effect of apomorphine changed more in the afternoon (1-3 p.m.) than in the morning (6-8 a.m.) or the evening (6-8 p.m.) hours. the act ...19883378603
stability of a bioactive gel covering a glass surface. 20123382135
[observation on the cidal effect of ws-i type insecticide coatings on mosquitoes, flies and cockroaches]. 20123383389
the phagocytic activity of lumbricus terrestris leukocytes is enhanced by the vertebrate opsonins: igg and complement c3b fragment.the effect of the vertebrates opsonins: igg and complement c3 fragments on phagocytic activity of lumbricus terrestris leukocytes towards sheep erythrocytes was studied. sheep erythrocytes were previously sensitized with specific igg or igm and coated with one of the third component fragments (c3b, c3bi, c3d) of human complement. our results show that leukocyte phagocytosis was enhanced by vertebrate igg and c3b complement fragments but not by igm and fragment c3d. because opsonization in verteb ...19883384156
[immunologic abnormality of collagen diseases, with special reference to rheumatoid arthritis]. 20123388147
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