Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| rate of bactericidal activity for branhamella catarrhalis of fleroxacin compared with that of amoxycillin-clavulanic acid. | the rate of bactericidal activity of fleroxacin was compared with that of the combination of amoxycillin and clavulanic acid (in the proportion of 4 to 1) on beta-lactamase producing strains of branhamella catarrhalis. the rate of bactericidal activity of 1 mg/l was as rapid as that of 1 mg/l of amoxycillin-clavulanic acid combination. this rate was not significantly more rapid if the concentrations of fleroxacin were increased to 10 mg/l. in conclusion, the bactericidal activity of fleroxacin i ... | 1988 | 3144548 |
| the antibiotic susceptibilities and beta-lactamase production of clinical isolated branhamella catarrhalis from acute otitis media in children. | branhamella catarrhalis has been misconsidered as a normal resident in human respiratory tract for a long time. however, many authors recently have reported its pathogenecity and isolated it from the otolaryngological region. in our study, this organism can be isolated from the ear and nasal discharge in the child with acute otitis media by the rate of 7.5% and 21.4% respectively. out of this 107 isolated strains, 97 strains (90.7%) were found to be beta-lactamase producing organisms. the mic me ... | 1988 | 3144965 |
| branhamella catarrhalis septicemia in an infant with aids. | branhamella catarrhalis was isolated in blood culture from a 6-month-old infant with aids. the child had a nasopharyngeal infection with respiratory syncytial virus and pneumonitis with pneumocystis carinii. commensal organisms such as b. catarrhalis may be potential pathogens in infants with aids. | 1988 | 3146808 |
| pneumonia due to branhamella catarrhalis. | in 12 of 451 patients diagnosed as having pneumonia in a single hospital over 18 months the causative organism appeared to be branhamella catarrhalis. | 1988 | 3146819 |
| in vitro evaluation of ceftibuten (7432-s, sch 39720), a novel orally administered cephalosporin. | 7432-s (sch 39720) was the most active beta-lactam tested against the enterobacteriaceae, inhibiting 92% of strains at less than or equal to 8.0 micrograms/ml compared to 82%, 65% and 39% of strains inhibited by cefixime, cefuroxime and cefaclor, respectively. 7432-s was also very effective against haemophilus influenzae (mic90, less than or equal to 0.25 microgram/ml), branhamella catarrhalis (mic90, 4.0 micrograms/ml) and neisseria meningitidis (mic90, less than or equal to 0.25 microgram/ml). ... | 1988 | 3147148 |
| branhamella catarrhalis: fatty acid and lipopolysaccharide analysis of an atypical strain from blood culture. | a branhamella catarrhalis-like organism was isolated from blood cultures; it was atypical in showing negative nitrate and nitrite and positive gamma-glutamylaminopeptidase reactions, in agglutinating with neisseria meningitidis antisera, and in forming butyrous colonies. cell-wall fatty-acid and lipopolysaccharide analysis provided evidence that this isolate was an atypical b. catarrhalis. | 1988 | 3147160 |
| selective medium for branhamella catarrhalis with acetazolamide as a specific inhibitor of neisseria spp. | several semiselective media for branhamella catarrhalis have been proposed. these media allow growth of all members of the family neisseriaceae, and further differentiation is necessary. by addition of 10 micrograms of acetazolamide, a carbonic anhydrase inhibitor, per ml and incubation in air, a medium was created which reduced growth of neisseria spp. when saliva samples from 178 healthy schoolchildren were screened for the presence of b. catarrhalis, the carrier rate for this organism was est ... | 1988 | 3147992 |
| characterization of a plasmid isolated from branhamella catarrhalis and detection of plasmid sequences within the genome of a b. catarrhalis strain. | we isolated a 12.2-kb plasmid from two clinical strains of branhamella catarrhalis and evaluated its distribution among other b. catarrhalis strains by colony hybridization experiments using the whole plasmid as a probe. homology was detected with the two plasmid-bearing strains and also with a third b. catarrhalis strain named e7, which is plasmidless. southern transfer analysis of total digested e7 dna using the purified plasmid as a probe revealed a single band of hybridization, different fro ... | 1988 | 3148947 |
| [recent trend of incidence of respiratory pathogenic bacteria and its susceptibility to antimicrobial agents: studies in the year 1984-1986]. | based on a quantitative analysis of sputum cultures, pathogenic bacteria in respiratory ailments isolated in our laboratory during 1984 to 1986 were classified and analyzed. during the study period, the most frequently isolated agent was haemophilus influenzae followed by pseudomonas aeruginosa, branhamella catarrhalis and streptococcus pneumoniae. they together consisted of 70 approximately 74% of all the respiratory pathogenic bacteria isolated in our study. susceptibilities of above pathogens ... | 1988 | 3149325 |
| [clinical experience with ofloxacin in the treatment of chronic respiratory tract disease aggravated by acute infection]. | we studied the clinical usefulness of ofloxacin (oflx) in 13 patients with chronic respiratory tract diseases aggravated by acute infections with identified causative bacteria. 1. overall clinical efficacies were: highly effective 5, effective 6, slightly effective 2, and ineffective none, showing an efficacy rate of 84.6%. 2. in 6 patients with fever of over 37 degrees c, time lengths in days for symptoms to have been alleviated due to oflx treatment were; 1 day: 4 cases, 3 days: 1 case and 5 d ... | 1988 | 3149326 |
| in-vitro activity of amoxycillin/clavulanic acid and five other oral antibiotics against clinical isolates of haemophilus influenzae and branhamella catarrhalis. | the in-vitro activity of amoxycillin/clavulanic acid, amoxycillin, erythromycin, doxycycline, chloramphenicol and cephalexin against 183 clinical isolates of haemophilus influenzae and 61 of branhamella catarrhalis was determined. amoxycillin/clavulanic acid showed the greatest activity against h. influenzae. all isolates of b. catarrhalis were susceptible to amoxycillin/clavulanic acid, chloramphenicol, cephalexin and doxycycline. | 1988 | 3149634 |
| [branhamella catarrhalis and bronchopulmonary infection]. | 1988 | 3149788 | |
| antimicrobial susceptibility testing of haemophilus influenzae, branhamella catarrhalis, and neisseria gonorrhoeae. | 1988 | 3149883 | |
| respiratory tract infections due to branhamella catarrhalis and neisseria species. | 1987 | 3151758 | |
| the pharmacokinetics and serum and urine bactericidal activity of ciprofloxacin. | ciprofloxacin is an investigational quinolone agent possessing an impressive antibacterial spectrum. its pharmacokinetics were studied in six volunteers after 250-mg and 500-mg single oral doses, and its bactericidal activity compared to that of trimethoprim-sulfamethoxazole given to the same volunteers. mean peak serum levels were 1.45 micrograms/ml and 2.46 micrograms/ml for 250-mg and 500-mg doses, and time to peak was 1 and 1.3 hours. the 12-hour levels were 0.12 micrograms and 0.22 microgra ... | 1985 | 3157705 |
| [laboratory and clinical studies of rokitamycin dry syrup in the field of pediatrics]. | laboratory and clinical studies on rokitamycin (rkm) dry syrup, a new macrolide antibiotic, were carried out in the field of pediatrics. the results are summarized as follows. 1. plasma concentrations and urinary recovery rates after oral administration on fasting of rkm dry syrup at doses of 10 mg/kg and 20 mg/kg to 2 and 1 cases, respectively, were determined. peak plasma levels were obtained in 30 minutes after administration of both dosages with half-lives of 1.5 to 2.2 hours. a clear-cut do ... | 1988 | 3172461 |
| in-vitro and in-vivo activities of t-3262, a new pyridone carboxylic acid. | t-3262[p-toluenesulfonic acid salt of dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid monohydrate] is a new pyridone carboxylic acid with a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria. the activity of t-3262 against most enterobacteriaceae was comparable with that of ciprofloxacin except proteus spp. and providencia rettgeri and exceeded that of ofloxacin and norfloxacin. the activ ... | 1988 | 3182417 |
| comparative in-vitro activity of tigemonam, a new monobactam. | the in-vitro activity against gram-negative aerobic bacterial pathogens of a new oral monobactam, tigemonam, was compared with those of amoxycillin/clavulanic acid, aztreonam, cefaclor, ceftazidime, cefuroxime, ciprofloxacin, co-trimoxazole and gentamicin, by an agar-dilution method. tigemonam inhibited 90% of strains tested of escherichia coli, klebsiella spp., proteus spp., salmonella spp., haemophilus influenzae and branhamella catarrhalis at concentrations of 0.25 mg/l or below. the mic90 fo ... | 1988 | 3182428 |
| antimicrobial activity of ly163892, an orally administered 1-carbacephem. | ly163892 was found to be similar to cefaclor and slightly superior to cephalexin in antimicrobial activity and spectrum. bacteria with mic50 less than or equal to 8.0 mg/l included escherichia coli, klebsiella spp., proteus mirabilis, citrobacter diversus, haemophilus influenzae, branhamella catarrhalis, pathogenic neisseria spp., oxacillin-susceptible staphylococci, and streptococcus spp. strains that produced plasmid-mediated beta-lactamases generally remained susceptible to ly163892. ly163892 ... | 1988 | 3182429 |
| bacteriological findings of acute maxillary sinusitis in young adults. | bacteriological findings in 339 sinus secretions obtained by puncture were investigated in 238 young adult patients with acute maxillary sinusitis. aerobic and anaerobic cultures were performed immediately. a total of 76% of the secretions were positive. the most common pathogens isolated were haemophilus influenzae (50%), streptococcus pneumoniae (19%), streptococcus pyogenes (5%), and branhamella catarrhalis (2%). coagulase-negative staphylococci and staphylococcus aureus were isolated in 8 an ... | 1988 | 3182986 |
| antimicrobial activity, spectrum, and recommendations for disk diffusion susceptibility testing of ceftibuten (7432-s; sch 39720), a new orally administered cephalosporin. | the antimicrobial activity and spectrum of ceftibuten (7432-s; sch 39720) was determined on a wide variety of bacterial species selected for resistance to oral and parenteral beta-lactam antimicrobial agents. ceftibuten was found to be the most active beta-lactam tested against members of the family enterobacteriaceae, inhibiting 81.6% of strains at less than or equal to 8.0 micrograms/ml compared with 75.0 and 54.8% of strains inhibited by cefixime and cefuroxime, respectively. all strains of h ... | 1988 | 3190185 |
| in vitro activity of u-76,252 (cs-807), a new oral cephalosporin. | u-76,252 is the prodrug of u-76,253. mics of u-76,253 were 0.015 to 0.06 microgram/ml for greater than or equal to 90% of the strains of streptococcus spp., haemophilus influenzae, and proteus mirabilis; 0.25 to 1 microgram/ml for branhamella catarrhalis, escherichia coli, klebsiella spp., and citrobacter diversus; 1 to 8 micrograms/ml for staphylococcus spp.; and 2 to greater than 16 micrograms/ml for other members of the family enterobacteriaceae and aeromonas hydrophila; for 72% of the latter ... | 1988 | 3190194 |
| in vitro activities of pd 117,596 and reference antibiotics against 448 clinical bacterial strains. | the in vitro activity of pd 117,596, a new fluoroquinolone antibiotic, was tested against 448 bacterial isolates (15 genera) by agar dilution (inoculum, 10(4) cfu per spot). the activity of pd 117,596 was compared with that of 15 antibiotics against 327 gram-negative strains and with that of 8 other antibiotics against 121 gram-positive strains. pd 117,596 demonstrated the best activity against klebsiella spp., enterobacter spp., acinetobacter spp., serratia marcescens, and branhamella catarrhal ... | 1988 | 3196008 |
| in vitro activity of cefixime, a new oral cephalosporin. | the in vitro activities of cefixime and seven comparative oral antimicrobials were studied. mic90s of cefixime were 0.015-1 micrograms/ml for haemophilus influenzae, branhamella catarrhalis, escherichia coli, klebsiella, citrobacter diversus, proteus, providencia, aeromonas hydrophila and streptococcus. mic90s for other enterobacteriaceae were greater than or equal to 2 micrograms/ml; 44% of those strains were inhibited by less than or equal 1 microgram/ml. staphylococcus, psuedomonas aeruginosa ... | 1988 | 3219746 |
| [clinical evaluation of s 6472 granule preparation (sustained-release cefaclor) in chronic bronchitis]. | s 6472 granule preparation, a sustained-release cefaclor, was orally administered to 20 acutely exacerbated cases of chronic bronchitis at a daily dosage of 750 mg (titer) in 2 divided doses for a duration of 7-15 days and its clinical usefulness was evaluated. clinical efficacies were good in 17 cases and fair in 3 cases, with a rate of efficacy of 85.0%. organisms isolated from 13 patients were totalling 14 strains, i.e., 5 strains of streptococcus pneumoniae, 3 strains of branhamella catarrha ... | 1988 | 3241328 |
| antibacterial activities of cefpodoxime, cefixime, and ceftriaxone. | cefpodoxime, cefixime, and ceftriaxone inhibited branhamella catarrhalis at less than or equal to 1 microgram/ml, beta-hemolytic streptococci at less than or equal to 0.25 microgram/ml, neisseria meningitidis at less than or equal to 0.06 microgram/ml, and haemophilus influenzae (other than beta-lactamase-negative, ampicillin-resistant isolates) at less than or equal to 0.12 microgram/ml. the mics for 50% of isolates of the family enterobacteriaceae other than citrobacter freundii, enterobacter ... | 1988 | 3245701 |
| antimicrobial activity of mdl 19,592: an oral cephalosporin. | mdl 19,592, a semisynthetic oral cephalosporin, has an antimicrobial spectrum principally directed against gram-positive cocci (mic50, 0.25-4 micrograms/ml), branhamella catarrhalis (mic50, 1-2 micrograms/ml), and pathogenic neisseria spp. such as meningococci (mic50, 4 micrograms/ml). enterobacteriaceae, enterococci, pseudomonas spp., corynebacterium jeikeium, and acinetobacter calcoaceticus strains had mdl 19,592 mic50 of greater than or equal to 32 micrograms/ml. although mdl 19,592 generally ... | 1988 | 3246143 |
| [pharmacokinetic, bacteriological and clinical studies of sultamicillin fine granule in pediatric field]. | pharmacokinetic, bacteriological and clinical studies on sultamicillin (sbtpc) fine granule were carried out in the field of pediatrics. the results obtained are summarized as follows. 1. antibacterial activities of sbtpc against clinically isolated strains of haemophilus influenzae, haemophilus parainfluenzae, streptococcus pneumoniae, streptococcus pyogenes, streptococcus agalactiae, staphylococcus aureus, branhamella catarrhalis, and escherichia coli were compared with those of ampicillin (ab ... | 1988 | 3249362 |
| comparative in vitro activities of new 14-, 15-, and 16-membered macrolides. | the in vitro activities of several 14-, 15- and 16-membered macrolides were compared with that of erythromycin. in general, 14-membered macrolides such as erythromycin, clarithromycin, and flurithromycin were more active against streptococci and bordetella pertussis than was the 15-membered macrolide azithromycin, which was more active than 16-membered macrolides such as miocamycin and rokitamycin. clarithromycin was the most active compound against streptococcus pyogenes, pneumococci, listeria ... | 1988 | 3252753 |
| beta-lactamase-producing bacteria in head and neck infection. | we have summarized our experience in recovery of beta-lactamase-producing bacteria (blpb) in head and neck infection (hni). these hni include conjunctivitis, serous and chronic otitis media, cholesteatoma, chronic mastoiditis, chronic sinusitis, adenoiditis, recurrent tonsillitis in children and adults, peritonsillar abscess, and retropharyngeal abscess. beta-lactamase-producing bacteria were found in 262 (51%) of 513 patients with hni; 72% had aerobic blpb and 57% had anaerobic blpb. the infect ... | 1988 | 3258396 |
| bmy-28100, a new oral cephalosporin: antimicrobial activity against nearly 7,000 recent clinical isolates, comparative potency with other oral agents, and activity against beta-lactamase producing isolates. | the antimicrobial activity of bmy-28100 was tested against approximately 7,000 bacterial pathogens in a multicenter, multiphased collaborative investigation. the bmy-28100 spectrum and antimicrobial potency was most similar to that of cefaclor and superior to that of cephalexin among currently available cephalosporins. species that had greater than or equal to 90% of clinical strains inhibited by bmy-28100 (less than or equal to 8.0 micrograms/ml) were: citrobacter diversus, escherichia coli, kl ... | 1988 | 3259489 |
| beta-lactamase production in the upper respiratory tract flora in relation to antibiotic consumption: a study in children attending day nurseries. | the occurrence of beta-lactamase production in haemophilus influenzae, branhamella catarrhalis and moraxella nonliquefaciens was compared in 191 healthy children attending day nurseries in 2 municipalities differing with regard to the prescription rate of beta-lactam antibiotics. a significantly higher frequency of beta-lactamase production was recorded in m. nonliquefaciens isolated in the municipality with the higher prescription rate. a corresponding difference was not recorded for h. influen ... | 1988 | 3261446 |
| staphylococcus epidermidis and staphylococcus aureus in otitis media with effusion. | bacteriologic investigation of middle ear effusion (mee), external ear canal, and the nasopharynx was carried out on 458 patients with otitis media with effusion. staphylococcus epidermidis was the most common bacteria in mee, even after excluding the contaminants from the external ear canal, which had the same value of minimal inhibitory concentration as the paired mee. the bacterial agreement of s epidermidis between mee and the nasopharynx was extremely rare in contrast with haemophilus influ ... | 1988 | 3262358 |
| in-vitro activity and beta-lactamase stability of ly163892. | ly163892 is a new orally absorbed carbacephem. it inhibited streptococcus pyogenes and str. pneumoniae at less than or equal to 1 mg/l, but was less active against group b streptococci and groups c, f, g and bovis streptococci with mics of 1 to 2 mg/l for most but as high as 8 mg/l for some isolates. mic90 of methicillin-susceptible staphylococcus aureus was 8 mg/l, but greater than 128 mg/l for methicillin-resistant staphylococci. ly163892 had activity similar to cefaclor and cephalexin with mi ... | 1988 | 3263352 |
| in vitro antibacterial activity of fk482, a new orally active cephalosporin. | fk482 is a new orally active cephem antibiotic which offers some advantages over the commercially available oral beta-lactam antibiotics. it displayed a broad spectrum of activity in vitro against stock strains of gram-positive and gram-negative aerobes and anaerobes. fk482 was more active in vitro than cefixime (cfix), cefaclor (ccl) or cephalexin (cex) against clinical isolates of gram-positive organisms such as methicillin-sensitive staphylococcus aureus, coagulase-negative staphylococci incl ... | 1988 | 3264828 |
| in vitro evaluations of aminopenicillin/beta-lactamase inhibitor combinations. | sulbactam/ampicillin (unasyn) possesses the antimicrobial activity of each drug plus the synergistic action and qualities of sulbactam used as a beta-lactamase inhibitor. the combination has a spectrum of activity against many enterobacteriaceae, haemophilus species, branhamella catarrhalis, pathogenic neisseria species, acinetobacter anitratus, some pseudomonads, nearly all anaerobes (including bacteroides), staphylococcus species, streptococci, and the enterococci. sulbactam/ampicillin was fou ... | 1988 | 3265377 |
| [antimicrobial activities of sultamicillin against clinical isolates from upper respiratory tract infections]. | sultamicillin (sbtpc) is a mutual prodrug in which ampicillin (abpc) and a potent beta-lactamase inhibitor sulbactam (sbt) are ester-bound in an equimolar ratio. sbtpc is hydrolyzed during absorption after oral administration to provide abpc and sbt for systemic circulation. in the present study, the antimicrobial activities of sbtpc against 50 isolates each of 6 species (staphylococcus aureus, klebsiella pneumoniae subsp. pneumoniae, branhamella catarrhalis, haemophilus influenzae, streptococcu ... | 1988 | 3266508 |
| [antimicrobial activity of sultamicillin against clinical isolates from upper respiratory tract infections ii]. | in an attempt to examine the effect of sulbactam (sbt) on beta-lactamase activity, three hundred clinical isolates from the infected upper respiratory tract were tested for mics and disk sensitivities of ampicillin (abpc) and sultamicillin (sbtpc). beta-lactamase production was tested using the acidometry disk method (beta-check, taito pfizer co.). for strains such as klebsiella spp. which form mucoid type colonies, we used the ss culture medium which, by reducing the influence of huge amounts o ... | 1988 | 3266883 |
| five vs. ten days of therapy for acute otitis media. | in a double blind study 175 patients with acute otitis media were randomized into 2 treatment groups: 10 days of therapy with cefaclor or 5 days of therapy followed by 5 days of placebo. the dosage of cefaclor was 40 mg/kg/day administered orally in equally divided doses at 12-hour intervals. tympanocentesis before treatment yielded specimens that contained streptococcus pneumoniae or haemophilus influenzae or both in 55% of specimens. branhamella catarrhalis was isolated from 21% of specimens. ... | 1988 | 3277153 |
| comparative activity of the 4-quinolones. | minimal inhibitory concentrations (mics) of the 4-quinolones ciprofloxacin, enoxacin, norfloxacin, ofloxacin, pefloxacin, difloxacin, a-56620, and ci-934 are consistent world-wide, with allowances for differences in acquired resistance. mics of these drugs for enterobacteriaceae correlate with those of nalidixic acid, but resistance to the quinolones is rare if a breakpoint of greater than 2 mg/l is accepted. most intestinal pathogens are sensitive. acinetobacter, pseudomonas aeruginosa, and oth ... | 1988 | 3279501 |
| tigemonam, an oral monobactam. | tigemonam is an orally administered monobactam. at less than or equal to 1 microgram/ml it inhibited the majority of strains of escherichia coli, klebsiella spp., enterobacter aerogenes, citrobacter diversus, proteus spp., providencia spp., aeromonas hydrophila, salmonella spp., shigella spp., serratia marcescens, and yersinia enterocolitica. at less than or equal to 0.25 microgram/ml it inhibited haemophilus spp., neisseria spp., and branhamella catarrhalis. it did not inhibit pseudomonas spp. ... | 1988 | 3279906 |
| comparative in vitro activity of a new fluorinated 4-quinolone, t-3262 (a-60969). | the in vitro activity of a new quinolone, t-3262 [a-60969; dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1-, 4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid monohydrate], was compared with those of ciprofloxacin, ofloxacin, ceftazidime, imipenem, and gentamicin. t-3262 inhibited 90% of isolates of the family enterobacteriaceae at a concentration of less than or equal to 0.25 micrograms/ml. it was two to four times more active than ofloxacin and similarly or slightly less acti ... | 1988 | 3293524 |
| aetiology of acute pharyngitis and clinical response to empirical therapy with erythromycin versus amoxicillin. | one hundred and eighty-nine adults with acute pharyngitis had culture and serological evaluation for group a beta haemolytic streptococci (gabhs), mycoplasma pneumoniae, and branhamella catarrhalis. sixteen patients had evidence for infection with gabhs, none for m. pneumoniae, and one for b. catarrhalis. for those with gabhs, there was no significant difference between empirical treatment by erythromycin or amoxicillin. for those without gabhs, empirical treatment with erythromycin appeared to ... | 1988 | 3294074 |
| branhamella catarrhalis conjunctivitis. | eleven cases of branhamella catarrhalis conjunctivitis have been reported. in four recent studies that examine the microbial etiology of ophthalmia neonatorum, b catarrhalis was identified only twice in 1,299 cases. however, diagnosis by gram stain in some and previous antibiotic therapy in others may have resulted in underdiagnosis of b catarrhalis and inaccurate diagnosis as gonococcal ophthalmia. | 1987 | 3299731 |
| comparative efficacies of erythromycin-sulfisoxazole and cefaclor in acute otitis media: a double blind randomized trial. | a prospective double blind trial compared the fixed combination of erythromycin-sulfisoxazole (e/s) with cefaclor in the treatment of acute otitis media. one hundred nineteen children in six centers across canada were studied. diagnostic tympanocentesis of 134 ears yielded 135 bacterial isolates: streptococcus pneumoniae (42%); haemophilus influenzae (21%); branhamella catarrhalis (10%); streptococcus pyogenes (5%); and other bacteria (22%). seventy-seven percent of strains of b. catarrhalis and ... | 1987 | 3302918 |
| meningitis due to branhamella catarrhalis. | we report a case of branhamella catarrhalis meningitis which was unusual in that the patient was a healthy immunocompetent adult, the onset was subacute, and the cerebrospinal fluid pleocytosis was predominantly lymphocytic. following treatment with intravenous penicillin, recovery was complete apart from residual cortical dysarthria. | 1987 | 3304249 |
| enzymatic modification of aminoglycoside antibiotics by branhamella catarrhalis carrying an r factor. | fifteen out of 89 clinical strains of branhamella catarrhalis isolated from patients at the university hospital of zaragoza were resistant to aminoglycosides and other antimicrobials. in two strains, b. catarrhalis 220 and b. catarrhalis 115, the resistance to aminoglycosides was associated with synthesis of aminoglycoside-modifying enzymes, namely 3"-o-phosphotransferase [aph(3")] and 3'-o-phosphotransferase [aph(3')]. b. catarrhalis 115 was resistant to ampicillin, streptomycin, kanamycin, neo ... | 1987 | 3304917 |
| cefuroxime axetil in acute purulent exacerbations of chronic bronchitis. | 51 hospitalised patients with acute purulent exacerbations of chronic bronchitis were treated for ten days with two daily 1 g doses of the orally absorbed pro-drug cefuroxime axetil. however, some patients were still infected with haemophilus influenzae or branhamella catarrhalis at follow-up, and sputum purulence remained. clinical results were "excellent" or "good" in 60% of the evaluable patients one week after the end of the treatment. mean peak serum concentrations averaged 12.8 mg/l with m ... | 1987 | 3312021 |
| randomized, open label, multicenter trial of cefixime compared with amoxicillin for treatment of acute otitis media with effusion. | cefixime, a new third generation cephalosporin antibiotic for oral use, was evaluated for safety and efficacy in the treatment of children with acute otitis media with effusion. fifteen united states clinical investigators participated in the multicenter clinical trial. one hundred twenty children were randomly assigned to a 10-day course of either cefixime, 8 mg/kg, given daily (qd) (60 patients) or amoxicillin, 40 mg/kg/day, administered in three divided doses (60 patients). tympanocentesis wa ... | 1987 | 3320928 |
| imipenem-cilastatin in the treatment of respiratory infections in patients with chronic airways obstruction. | chest infections with organisms resistant to conventional antibiotics are common in patients with chronic lung disease. we have studied the use of imipenem in 40 (28 m 12 f) patients admitted for treatment of chest infections. patients were treated with imipenem 0.5 g four times daily by intravenous infusion for 6.3 +/- 1.6 (s.d.) days. forty-six respiratory pathogens were cultured from 36 patients including 18 haemophilus influenzae, 6 h. parainfluenzae, 6 streptococcus pneumoniae, 8 pseudomona ... | 1988 | 3356618 |
| in vitro activity of flomoxef in comparison to other cephalosporins. | flomoxef and cefazolin had nearly the same activity against staphylococci, which was stronger than that of other cephalosporins. against streptococcus pyogenes, streptococcus agalactiae and streptococcus pneumoniae, cefotaxime and cefazolin were more active than flomoxef, but the other cephamycins were less active than flomoxef. in comparison to the other cephalosporins, latamoxef and flomoxef had higher activity against branhamella catarrhalis, whereas cefotaxime, latamoxef and cefotetan were m ... | 1988 | 3372024 |
| antimicrobial activity and disk diffusion susceptibility testing of u-76,253a (r-3746), the active metabolite of the new cephalosporin ester, u-76,252 (cs-807). | compound u-76,253a (r-3746), the active metabolite sodium salt of the prodrug ester u-76,252 (cs-807), was demonstrated to be active against members of the family enterobacteriaceae with 82 and 85% of strains inhibited by less than or equal to 2.0 and less than or equal to 4.0 micrograms/ml, respectively. in addition, u-76,253a inhibited all strains of branhamella catarrhalis, haemophilus influenzae, pathogenic neisseria spp., oxacillin-susceptible staphylococcus aureus, beta-hemolytic streptoco ... | 1988 | 3377457 |
| prevalence and persistence of neisseria cinerea and other neisseria spp. in adults. | neisseria cinerea is a commensal neisseria sp. which was first described in 1906 but was subsequently misclassified as a subtype of branhamella catarrhalis. n. cinerea resembles neisseria gonorrhoeae in both cultural and biochemical characteristics and, thus, may also have been misidentified as n. gonorrhoeae. of 202 patients whose oropharynges were colonized by neisseria spp., n. cinerea was isolated in 57 (28.2%) patients, including 25 (30.1%) of 83 women, 22 (23.9%) of 92 heterosexual men, an ... | 1988 | 3384913 |
| the in-vitro activity of roxithromycin, a new macrolide antibiotic, in comparison with that of erythromycin. | a study was made of the in-vitro activity of roxithromycin in comparison with that of erythromycin on selected recent clinical isolates of a wide range of organisms. minimum inhibitory concentrations (mics) were determined by an agar dilution method with an inoculum of 10(4) cfu. minimum bactericidal concentrations (mbcs) and the effect of ph were determined by a broth dilution method on selected strains. in general the in-vitro activity of roxithromycin mirrored that of erythromycin, but it was ... | 1987 | 3428135 |
| [the study of flomoxef in the pediatric field]. | flomoxef (fmox; 6315-s), a new synthetic oxacephem antibiotic, was studied in the pediatric field and pharmacokinetic and clinical results obtained were summarized below. 1. the activity of fmox against staphylococcus aureus isolated from clinical patients, including latamoxef resistant strains was very high and mic was approximately less than or equal to 0.39 microgram/ml. this mic value was lower than other cephem antibiotics such as cefotaxime, cefotiam, cefmetazole, cefamandole. the distribu ... | 1987 | 3430712 |
| respiratory infections: clinical experiences with the new quinolones. | nearly 300 patients, admitted to hospital with acute purulent exacerbations of chronic respiratory disease, have been treated with various newer quinolones: 26 patients received enoxacin, 50 pefloxacin, 80 ciprofloxacin and 143 ofloxacin. dosages varied from 400 mg once daily to 1000 mg twice daily. orally for five to 10 days. patients were evaluated bacteriologically and clinically before, during and after treatment. nearly all infections associated with haemophilus influenzae and/or branhamell ... | 1987 | 3438151 |
| [clinical evaluations of flomoxef in respiratory tract infections]. | flomoxef (fmox, 6315-s), a new antibacterial drug, was administered to 9 cases with respiratory tract infections for a duration of 8 approximately 16 days at a daily dose of 2 g. diagnosis of these patients were bronchopneumonia 5 cases, chronic bronchitis 3 cases and acute bronchitis 1 case. from transtracheal aspiration several organisms were isolated; haemophilus influenzae was isolated in 3 cases, streptococcus pneumoniae in 3 cases, h. influenzae plus branhamella catarrhalis in 1 case, stre ... | 1987 | 3444019 |
| branhamella catarrhalis: a respiratory pathogen in children? | 1986 | 3463283 | |
| the comparative in-vitro activity of eight newer quinolones and nalidixic acid. | the in-vitro antibacterial activity of nalidixic acid and the 4-quinolones, ciprofloxacin, norfloxacin, enoxacin, ofloxacin, pefloxacin, a-56619, a-56620 and ci-934 was assessed by determination of mics. the 4-quinolones were all highly active against most isolates of enterobacteriaceae, including nalidixic acid-resistant strains. ciprofloxacin (mics 0.002-2 mg/l) was the most active and a-56619 (mics 0.008-32 mg/l) was the least active. a-56619, a-56620, ofloxacin, ciprofloxacin and ci-934 were ... | 1986 | 3468100 |
| branhamella catarrhalis, a respiratory tract pathogen. | 1986 | 3469976 | |
| fatal branhamella catarrhalis pneumonia. | 1987 | 3475613 | |
| penetration of ofloxacin into bronchial secretions. | the penetration of ofloxacin into bronchial secretions was evaluated in 16 patients after administration of a single oral dose of ofloxacin 400mg. bronchial secretions were aspirated at bronchoscopy after 1 to 6 hours and serum was collected simultaneously. ofloxacin concentrations were measured by a microbiological assay method. considerable individual variations in serum and bronchial aspirate concentrations were recorded: bronchial aspirate concentrations varied between 1.1 mg/l and 4.5 mg/l ... | 1987 | 3481325 |
| bacterial pneumonia in patients with the acquired immunodeficiency syndrome. | eighteen episodes of community-acquired bacterial pneumonia were diagnosed in 13 patients among 336 with the acquired immunodeficiency syndrome (aids) cared for at memorial sloan-kettering cancer center since 1979. bacterial pathogens isolated in 16 of 18 episodes were haemophilus influenzae in 8, streptococcus pneumoniae in 6, group b streptococcus in 1, and branhamella catarrhalis in 1. eight episodes were presumed pneumocystis carinii pneumonia until cultures obtained at bronchoscopy confirme ... | 1986 | 3484420 |
| in vitro activity of an orally administered cephalosporin, ly164846, against potentially pathogenic respiratory and dermal bacterial isolates. | the antibacterial activity of ly164846, a new orally administered semisynthetic cephalosporin, was compared with that of amoxicillin-clavulanic acid against 492 potentially pathogenic respiratory tract and dermal isolates. against groups a, b, and g streptococci; pneumococci; staphylococci (other than methicillin resistant); haemophilus influenzae; branhamella catarrhalis; and meningococci, the mics for 90% of strains tested of ly164846 and amoxicillin-clavulanic acid were less than or equal to ... | 1986 | 3486628 |
| purification and properties of a beta-lactamase produced by branhamella catarrhalis. | a beta-lactamase from branhamella catarrhalis was purified by column chromatography. the purified enzyme hydrolyzed penicillins, such as ampicillin, carbenicillin, and piperacillin, more rapidly than cephalosporins. furthermore, the enzyme hydrolyzed cefotaxime and cefmenoxime. the molecular weight of the enzyme was 33,000. the pi was 5.4. | 1986 | 3486631 |
| characteristics of human b cells responsive to the t-independent mitogen branhamella catarrhalis. | non-t cells from tonsil or blood were fractionated according to buoyant density, isotype of surface immunoglobulin, or the ability to form rosettes with mouse erythrocytes. each fraction was tested for the ability to proliferate in response to b. catarrhalis (bc) and, for comparison, staphylococcus aureus cowan 1 (sac) or an mlr supernatant (tf). cells in all density fractions responded to bc, the greatest response occurring in the high-density cell fraction. sac could similarly induce prolifera ... | 1986 | 3486820 |
| incidence of branhamella catarrhalis in the sputa of patients with chronic lung disease. | the incidence of branhamella catarrhalis in the respiratory tract of adults, especially in the united states, is not known. during the 30-month period from january 1983 to june 1985, 4180 sputum and endotracheal samples from patients in a hospital for chest diseases were evaluated. all samples were acceptable for gram-stain analysis and/or culture based on published cellular criteria. using primarily gram-stain directed cultures, 220 isolates of b. catarrhalis were identified in 180 patients, be ... | 1986 | 3488188 |
| the incidence and antibiotic susceptibility of branhamella catarrhalis in respiratory infections. | the incidence of branhamella catarrhalis in respiratory infections at city hospital, edinburgh from january 1981 to april 1984 is described. beginning in january 1982 there was an increased incidence associated with a high proportion of beta-lactamase-producing strains. the number of these strains increased: from january 1981 to april 1983, 61% of strains produced beta-lactamase, and 83% produced beta-lactamase from january to april 1984. 53% of patients were infected in hospital. environmental ... | 1986 | 3488189 |
| upper respiratory tract infections. ecological and therapeutic aspects of beta-lactamase production with special reference to branhamella catarrhalis. | available data indicate that the most common beta-lactamase produced by branhamella catarrhalis is plasmid mediated. the same enzyme occurs in moraxella nonliquefaciens, a commensal in the upper respiratory tract. the ability to produce the enzyme, which is known as bro-1, can be transferred by conjugation from m. nonliquefaciens to b. catarrhalis. since the first beta-lactamase-producing strains of b. catarrhalis appeared in 1977, the frequency of beta-lactamase production has increased rapidly ... | 1986 | 3488190 |
| therapy of acute otitis media caused by branhamella catarrhalis. preliminary report. | since 1980, we have observed an increased incidence of otitis media caused by branhamella catarrhalis. the outcome of therapy of acute otitis media caused by this organism has been studied in a number of randomised clinical trials. 75% of isolates produced beta-lactamase. failure to sterilise b. catarrhalis-infected middle ear exudates occurred in 3 of 11 patients treated with amoxycillin or bacampicillin, 2 of 19 treated with cefaclor, but in no patients treated with co-trimoxazole (n = 10) or ... | 1986 | 3488191 |
| acute otitis media in sweden. role of branhamella catarrhalis and the rationale for choice of antimicrobial therapy. | the occurrence of branhamella catarrhalis in the nasopharynx and middle ear exudate was investigated in 3 studies. bacteria were isolated from the nasopharynx in 63% of 180 healthy children and b. catarrhalis, the most common bacterium present, was isolated in 36%. in 75 children with primary acute otitis media, bacteria were isolated from the nasopharynx in 98% and from the middle ear exudate in 80%. b. catarrhalis was found in the nasopharynx in 43% and in the middle ear exudate in pure cultur ... | 1986 | 3488192 |
| sensitivity of branhamella catarrhalis to oral antibiotics. | b. catarrhalis is a potential pathogen in the upper and lower respiratory tract which has been implicated as a clinically important cause of chronic bronchitis and otitis media in children. since the late 1970s the proportion of b. catarrhalis strains elaborating beta-lactamase seems to have significantly increased; some centres are now reporting prevalence rates as high as 76%. such a dramatic increase in the number of beta-lactamase positive strains is of clinical importance when assessing the ... | 1986 | 3488193 |
| analysis of the relationship between ampicillin resistance and beta-lactamase production in branhamella catarrhalis. | 23 strains of branhamella catarrhalis, mainly isolated from patients with acute exacerbations of chronic bronchitis, were studied. the strains were selected on the basis of a positive beta-lactamase reaction using the cefinase disc or the nitrocefin method. no bands were visible by isoelectric focusing of the crude enzyme extracts of strains showing a weak positive reaction with the cefinase method. in the 15 remaining strains, at least 6 different isoelectric focusing patterns could be detected ... | 1986 | 3488194 |
| epidemiological and bacteriological findings on branhamella catarrhalis respiratory infections in the netherlands. | the frequency of isolation of branhamella catarrhalis from sputum in a laboratory in the southern part of the netherlands is reviewed; at present 23% of positive cultures contain these organisms. seasonal variations include a considerable reduction in frequency of isolation in the summer months. the possible role of heavy industry and air pollution is briefly discussed. evidence for the direct pathogenicity of b. catarrhalis is presented, and although this may be considered as only circumstantia ... | 1986 | 3488195 |
| classification of beta-lactamases from branhamella catarrhalis in relation to penicillinases produced by other bacterial species. | branhamella catarrhalis strains resistant to commonly used penicillins, and presently isolated, produce a beta-lactamase. most of these enzymes are chromosomally mediated, but a plasmid-mediated beta-lactamase has been described (enzyme bro-1). with reference to isoelectric points, 7 different enzymes have been identified: 6 chromosomally mediated and 1 plasmid-mediated. nevertheless, they have many common properties, such as being biosynthesised constitutively but with a low level of production ... | 1986 | 3488196 |
| isoelectric focusing of beta-lactamases from sputum and middle ear isolates of branhamella catarrhalis recovered in the united states. | branhamella catarrhalis obtained from the sputum of 146 patients with lower respiratory tract disease and from middle ear fluids of 26 children with otitis media were evaluated for beta-lactamase activity and the enzymes were characterised by isoelectric focusing (ief). 71% (103 of 146) of the sputum isolates and 77% (20 of 26) of the ear isolates produced beta-lactamase. by ief, the beta-lactamases of 113 of 123 (92%) strains revealed patterns identical with the ravasio type strain, having uniq ... | 1986 | 3488197 |
| plasmid-mediated beta-lactamase in branhamella catarrhalis. | the plasmid-mediated beta-lactamase in branhamella catarrhalis (bro-1), also occurring in moraxella nonliquefaciens, differs from other known plasmid-mediated beta-lactamases in gram-negative bacteria regarding substrate profile and isoelectric point. b. catarrhalis strains previously reported to produce beta-lactamases deviating from bro-1 were tested, and the beta-lactamases did not differ significantly from bro-1 in substrate profile, isoelectric point or relative substrate affinity index (rs ... | 1986 | 3488198 |
| inhibition of the beta-lactamases of branhamella catarrhalis by clavulanic acid and other inhibitors. | the beta-lactamases of branhamella catarrhalis ravasio and strain 1908 were readily inhibited by low concentrations of sulbactam, beta-halopenicillanic acids, mm 13902 and clavulanic acid. more detailed studies on the interaction of the ravasio beta-lactamase with clavulanic acid demonstrated that the enzyme had high affinity for the inhibitor (ki = 0.07 mumol/l) and was rapidly inhibited (t1/2 = 21 sec, kinhib. = 0.033/sec). two types of enzyme-inhibitor complex were formed, a transiently stabl ... | 1986 | 3488199 |
| inhibition of beta-lactamases in branhamella catarrhalis. | 1986 | 3488200 | |
| clinical and bacteriological evaluation of branhamella catarrhalis in respiratory infections. | the clinical significance of branhamella catarrhalis in respiratory infections is evaluated. 175 strains were isolated, mainly from the sputum, in 71 patients with respiratory infections. b. catarrhalis was most frequently isolated in mixed infections with haemophilus influenzae (38.3%), h. influenzae plus streptococcus pneumoniae (10.3%) or s. pneumoniae (9.7%). the rate of isolation of b. catarrhalis alone was as low as 5.1% and from mixed infections with pseudomonas aeruginosa, escherichia co ... | 1986 | 3488201 |
| direct and indirect pathogenicity of branhamella catarrhalis. | branhamella catarrhalis has been recovered from various sites of infection in the respiratory tract. these include chronic otitis media, tonsillitis, adenoiditis and pneumonia. this organism was recovered in many of these infections mixed with other aerobic, facultative anaerobic and anaerobic bacteria. increasing numbers of isolates of this organism have been noted to produce beta-lactamase. this may contribute to the high failure rate of penicillins in eradicating polymicrobial respiratory inf ... | 1986 | 3488202 |
| in honor of dr. sarah branham, a star is born. the realization of branhamella catarrhalis as a respiratory pathogen. | 1986 | 3488878 | |
| growth-enhancing effect of branhamella catarrhalis culture filtrates on the l-forms of haemophilus influenzae. | haemophilus influenzae is a common respiratory pathogen and recurrent infection due to h. influenzae is a phenomenon often present in patients with chronic respiratory tract infections. the effects of neisseria perflava and b. catarrhalis culture filtrates on the growth and reversion of h. influenzae l-forms were determined using the l-forms of h. influenzae induced and subcultured in a medium containing 10% sucrose and these culture filtrates. when each culture filtrate of two strains of n. per ... | 1986 | 3490015 |
| growth-enhancing effects of culture filtrates of sputum isolates on the l-forms of haemophilus influenzae. | the growth-enhancing effects of culture filtrates of respiratory pathogenic bacteria, including haemophilus influenzae, as well as normal floral bacteria other than neisseria perflava and branhamella catarrhalis on l-forms of h. influenzae were examined in vitro, using five species of major respiratory pathogenic bacteria and seven species of normal floral bacteria commonly isolated from the sputum of patients with chronic respiratory tract infections. the growth-enhancing factor(s) was present ... | 1986 | 3490016 |
| in vitro activity and beta-lactamase stability of two oral cephalosporins, ceftetrame (ro 19-5247) and cefetamet (ro 15-8074). | ceftetrame (ro 19-5247) and cefetamet (ro 15-8074), two new orally administered aminothiazolyl imimomethoxy cephalosporins, inhibited hemolytic streptococci and streptococcus pneumoniae at less than or equal to 0.5 micrograms/ml but were less active against staphylococci than were cephalexin and cefaclor. they did not inhibit s. faecalis, s. faecium, listeria monocytogenes, corynebacterium jk species, or pseudomonas aeruginosa. haemophilus influenzae, branhamella catarrhalis, and neisseria gonor ... | 1986 | 3490827 |
| beta-lactamase production in the upper respiratory tract flora. | in order to determine the recovery rate of species of the genera haemophilus and moraxella (including subgenus branhamella) from the upper respiratory tract and the incidence of beta-lactamase production within these genera, cultures were made of nose and throat swab specimens and adenoid tissue in 50 children undergoing adenoidectomy. haemophilus influenzae was isolated from 92% of the children. all children harboured strains of haemophilus spp. and in 46%, at least one strain produced the tem- ... | 1986 | 3490974 |
| disk diffusion susceptibility of branhamella catarrhalis and relationship of beta-lactam zone size to beta-lactamase production. | we tested 231 isolates of branhamella catarrhalis for beta-lactamase production and drug susceptibility by the national committee for clinical laboratory standards disk diffusion method. the nitrocephin disk (cefinase) identified beta-lactamase in 98% of the enzyme-producing strains, and a zone diameter of inhibition of less than or equal to 29 mm for penicillin correctly predicted the presence of beta-lactamase in 99% of the isolates. no resistance to erythromycin, tetracycline, trimethoprim-su ... | 1986 | 3492178 |
| in vitro activity of amoxicillin plus clavulanic acid against haemophilus influenzae and branhamella catarrhalis. | the in vitro activity of amoxicillin in the presence of clavulanic acid against clinical isolates of haemophilus influenzae and branhamella catarrhalis was assessed in comparison with ampicillin, amoxicillin, cefaclor and erythromycin. the isolates were selected so as to yield equal numbers of beta-lactamase producing and non-beta-lactamase producing strains of the two species. mics obtained by agar dilution indicated that amoxicillin in the presence of clavulanic acid was the most active of the ... | 1986 | 3492374 |
| activation of b chronic lymphocytic leukaemia cells by branhamella catarrhalis. | cells from the blood of patients with chronic lymphocytic leukaemia were cultured in the presence of two polyclonal activators of human b cells, the bacteria branhamella catarrhalis (bc) and staphylococcus aureus cowan 1 (sac). although the magnitude of the responses varied, cells from seven of the eight patients studied were induced to proliferate in response to bc. in contrast, the response to sac was low or negligible in seven of the eight patients, and only one patient responded well to this ... | 1987 | 3493206 |
| acute otitis media caused by branhamella catarrhalis: biology and therapy. | since 1980, we have observed an epidemic of otitis media caused by branhamella catarrhalis. this event was characterized by studying the nasopharyngeal colonization of infants and children with b. catarrhalis and the clinical presentation and therapeutic outcome of acute otitis media caused by this organism. pharyngeal colonization with b. catarrhalis was commoner in winter than summer. b. catarrhalis was present in middle-ear fluid (mef) of 17% of children with otitis media, and was commoner in ... | 1987 | 3493519 |
| susceptibility of branhamella catarrhalis to sulphamethoxazole and trimethoprim. | fifty strains of branhamella catarrhalis were examined for susceptibility to sulphamethoxazole, trimethoprim and a combination of the two by determinating minimum inhibitory concentrations (mics) and fractional inhibitory concentrations (fics). all strains were susceptible to sulphamethoxazole and resistant to trimethoprim. on the basis of the mic results it was predicted that greater synergy between sulphamethoxazole and trimethoprim would be observed with approximately equal proportions of eac ... | 1987 | 3494008 |
| amoxycillin/clavulanate in acute purulent exacerbations of chronic bronchitis. | twenty patients, all admitted to hospital with acute purulent exacerbations of chronic bronchitis associated with haemophilus influenzae, streptococcus pneumoniae or beta-lactamase producing branhamella catarrhalis were treated twice daily for ten days with amoxycillin/clavulanate. ten patients were first given 1000 mg amoxycillin with 200 mg potassium clavulanate intravenously bd for three days, before crossing to the standard oral regimen of 1000 mg amoxycillin + 250 mg potassium clavulanate b ... | 1987 | 3494724 |
| [acute sinusitis in adults]. | an average of 1.4% of the more than 30,000 participants in a treatment study were diagnosed as having acute sinusitis. 62% of all cases of sinusitis arose in patients aged between 15 and 44 years. treatment with antibiotics is indicated in purulent sinusitis whilst non-purulent sinusitis is treated either with local or systemic antiphlogistic agents. the secondary bacterial infection is usually caused by haemophilus influenzae, streptococcus pneumoniae and anaerobic bacteria. in scandinavia thes ... | 1987 | 3497108 |
| comparative antibacterial activity of the new oral cephalosporin bmy-28100. | the in vitro activity of bmy-28100 was compared with that of four other oral cephalosporins against gram-positive cocci, branhamella catarrhalis and haemophilus influenzae. bmy-28100 showed 5-20 times better activity against staphylococci and streptococci. methicillin-resistant staphylococci and enterococci were resistant to the drug. branhamella catarrhalis and haemophilus influenzae strains were moderately susceptible. time-kill curve studies showed bmy-28100 to be equally as active as benzylp ... | 1987 | 3497804 |
| detection of beta-lactamase activity among clinical isolates of branhamella catarrhalis with six different beta-lactamase assays. | a total of 74 different clinical isolates of branhamella catarrhalis were examined for their ability to produce beta-lactamase by six different beta-lactamase assays. these included a conventional tube and disk test, in which the chromogenic cephalosporin nitrocefin was used as a substrate; a disk procedure, in which pyridinium-2-azo-p-dimethylanaline cephalosporin was used as a substrate; broth and disk acidometric methods; and a conventional tube iodometric assay. a total of 58 of the study is ... | 1987 | 3497942 |
| in vitro and in vivo antibacterial activities of t-2588, a new oral cephalosporin, compared with those of other oral beta-lactam antibiotics. | t-2588, the pivaloyloxymethyl ester of t-2525, [6r, 7r]-7-[(z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetoamido] -3- [(5-methyl-2h-tetrazol-2-yl)methyl]-3-cephem-4-carboxylic acid, is a new oral cephalosporin. t-2525 had a widely expanded antibacterial spectrum against gram-negative and gram-positive bacteria. t-2525 was more active in vitro than cefaclor, cephalexin, and amoxicillin against members of the family enterobacteriaceae and branhamella catarrhalis. moreover, it exhibited superior in ... | 1987 | 3499115 |
| branhamella catarrhalis--an emerging human pathogen. | 1986 | 3514103 | |
| [respiratory tract infections--clinical results with ofloxacin]. | in an open clinical trial, out-patients with respiratory tract infections were given 200 mg ofloxacin b. i. d. orally. 36 had acute bronchitis and pneumonia was diagnosed in 44. the average duration of therapy was nine days for bronchitis and 12 days for pneumonia. in the sputum of bronchitis patients, haemophilus influenzae (n = 25), streptococcus pneumoniae (n = 18), branhamella catarrhalis (n = 2) and pasteurella multocida (n = 1) were isolated. 17 h. influenzae and 12 s. pneumoniae were elim ... | 1986 | 3514472 |
| lack of immunoglobulin a1 protease production by branhamella catarrhalis. | clinical isolates of branhamella catarrhalis from the sputum of 20 patients with acute bronchopulmonary infection were examined for synthesis of immunoglobulin a1 protease by immunoelectrophoresis. ten strains produced beta-lactamase, and 10 were beta-lactamase negative. none of the strains demonstrated immunoglobulin a1 protease activity despite the fact that three different culture media were used. | 1986 | 3516884 |
| significance of the sulfonamide component for the clinical efficacy of trimethoprim-sulfonamide combinations. | the reasons for combining trimethoprim (tmp) with sulfonamides (sul) are still mainly theoretical but are supported by results from experimental infections and treatment of specific pathogens in humans, such as branhamella catarrhalis, neisseria gonorrhoeae, brucella, nocardia asteroides and perhaps bordetella pertussis and chlamydia trachomatis. addition of sul to tmp confers a therapeutic advantage also in patients with complicated urinary tract infection but probably not in young women with a ... | 1986 | 3518051 |