Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| tafro syndrome: new subtype of idiopathic multicentric castleman disease. | castleman disease (cd) describes a group of three rare and poorly understood lymphoproliferative disorders that have heterogeneous clinical symptoms and common lymph node histopathological features. unicentric cd (ucd) involves a single region of enlarged nodes. multicentric cd (mcd) involves multiple regions of enlarged lymph nodes, constitutional symptoms, and organ dysfunction due to a cytokine storm often including interleukin 6. mcd is further divided into human herpes virus-8 (hhv-8)-assoc ... | 2017 | 28135567 |
| relapse of hhv8-positive multicentric castleman disease following rituximab-based therapy in hiv-positive patients. | successful treatment of hiv-associated multicentric castleman disease (hiv+mcd) with rituximab-based approaches has dramatically improved survival and reduced the risk of human herpesvirus 8 (hhv8)-associated lymphoma. longer term outcomes including relapse rates have not been described and are important to establish the potential role of maintenance therapy. a prospective cohort of 84 patients with biopsy-proven hiv+mcd were treated with risk-stratified rituximab-based therapy. four patients (5 ... | 2017 | 28143881 |
| up-regulation of tumor suppressor genes by exogenous dhc16-cer contributes to its anti-cancer activity in primary effusion lymphoma. | primary effusion lymphoma (pel) is a rare and highly aggressive b-cell malignancy with kaposi's sarcoma-associated herpesvirus (kshv) infection, while lack of effective therapies. our recent data indicated that targeting the sphingolipid metabolism by either sphingosine kinase inhibitor or exogenous ceramide species induces pel cell apoptosis and suppresses tumor progression in vivo. however, the underlying mechanisms for these exogenous ceramides "killing" pel cells remain largely unknown. base ... | 2017 | 28146424 |
| successful treatment of classic kaposi sarcoma with long-pulse neodymium-doped yttrium aluminum garnet laser: a preliminary study. | kaposi sarcoma (ks) is a systemic disease that can present with cutaneous lesions with or without internal involvement, mostly caused by infection with human herpesvirus-8. the treatment options include surgical excision, cryotherapy, radiotherapy, intralesional chemotherapy, laser, and elastic stockings for the prevention of lymphedema. | 2017 | 28157730 |
| methylseleninic acid and sodium selenite induce severe er stress and subsequent apoptosis through upr activation in pel cells. | selenium compounds such as methylseleninic acid (msa) and sodium selenite (ss) have been widely evaluated as potential anti-cancer agents in the clinical setting. primary effusion lymphoma (pel) is a non-hodgkin's b-cell lymphoma, associated with immunosuppressed individuals, such as post-transplant or aids patients. kaposi's sarcoma-associated herpesvirus (kshv) is the causative agent of pel and kaposi's sarcoma. here, we found that msa and ss markedly inhibited the growth of pel cells compared ... | 2017 | 28161410 |
| kaposi's sarcoma-associated herpesvirus (kshv)-encoded micrornas promote matrix metalloproteinases (mmps) expression and pro-angiogenic cytokine secretion in endothelial cells. | the human oncogenic virus kaposi's sarcoma-associated herpesvirus (kshv) is linked to kaposi's sarcoma (ks), a tumor of endothelial cells characterized by angiogenesis and invasiveness. kshv genome encodes 25 mature micrornas (mirnas), but their roles in kshv-induced tumor dissemination and angiogenesis are not fully understood. in this study, we constructed the sensor reporters of kshv mirnas and used a luciferase reporter assay to demonstrate the function of the mimics of kshv mirnas. then, we ... | 2017 | 28165144 |
| castlemans disease - surgical treatment, case reports. | the authors describe their experience with surgical treatment of benign rare lymph proliferation - castlemans disease (cd). it occurs in unicentric and multicentric forms. the very low incidence of the disease makes it very difficult to design larger prospective studies. cases of two leading localizations of the unicentric form of cd - intrathoracic and retroperitoneal with special emphasis on the preoperative diagnosis and imaging options are described. this article underlines the curative pote ... | 2016 | 28182443 |
| molecular epidemiology of kaposi's sarcoma-associated herpes virus, and risk factors in hiv-infected patients in tehran, 2014. | kaposi's sarcoma (ks) remains the most common malignancy among hiv-infected patients. human herpesvirus type-8 (hhv-8) is regarded as the infectious etiological agent of kaposi's sarcoma (kshv). diagnostic procedures associated with kshv are not routinely performed in hiv-infected subjects. | 2016 | 28191343 |
| simultaneous detection of dual nucleic acids using a sers-based lateral flow assay biosensor. | a new class of surface-enhanced raman scattering (sers)-based lateral flow assay (lfa) biosensor has been developed for the simultaneous detection of dual dna markers. the lfa strip in this sensor was composed of two test lines and one control line. sers nano tags labeled with detection dna probes were used for quantitative evaluation of dual dna markers with high sensitivity. target dna, associated with kaposi's sarcoma-associated herpesvirus (kshv) and bacillary angiomatosis (ba), were tested ... | 2017 | 28194991 |
| cutaneous plasmacytosis resembling pityriasis rosea in a 66-year-old white woman: a rare disease presenting in an unusual patient demographic. | 2017 | 28203625 | |
| elevated serum interferon γ-induced protein 10 kda is associated with tafro syndrome. | multicentric castleman disease (mcd) is a heterogeneous lymphoproliferative disorder. it is characterized by inflammatory symptoms, and interleukin (il)-6 contributes to the disease pathogenesis. human herpesvirus 8 (hhv-8) often drives hypercytokinemia in mcd, although the etiology of hhv-8-negative mcd is idiopathic (imcd). a distinct subtype of imcd that shares a constellation of clinical features including thrombocytopenia (t), anasarca (a), fever (f), reticulin fibrosis (r), and organomegal ... | 2017 | 28205564 |
| sumo modification of a heterochromatin histone demethylase jmjd2a enables viral gene transactivation and viral replication. | small ubiquitin-like modifier (sumo) modification of chromatin has profound effects on transcription regulation. by using kaposi's sarcoma associated herpesvirus (kshv) as a model, we recently demonstrated that epigenetic modification of viral chromatin by sumo-2/3 is involved in regulating gene expression and viral reactivation. however, how this modification orchestrates transcription reprogramming through targeting histone modifying enzymes remains largely unknown. here we show that jmjd2a, t ... | 2017 | 28212444 |
| pulmonary kaposi sarcoma with osseous metastases in an human immunodeficiency virus (hiv) patient: a remarkable response to highly active antiretroviral therapy. | background kaposi sarcoma (ks) is known to involve the mucocutaneous tissues and the aero-digestive tracts. in acquired immune deficiency syndrome (aids) patients, ks has an aggressive course and carries poor prognosis. we present a case of pulmonary ks with osseous metastases as the first presentation of human immunodeficiency virus (hiv) infection in a young male. the lesions impressively decreased in size and numbers following initiation of highly active antiretroviral therapy (haart). case r ... | 2017 | 28216610 |
| hepatic kaposi sarcoma: a case report and review of the literature. | kaposi sarcoma (ks) is an aggressive cancer caused by human herpesvirus-8, primarily seen in immunocompromised patients. as opposed to the well-described cutaneous manifestations and pulmonary complications of ks, hepatic ks is rarely reported before death as most patients with hepatic ks do not manifest symptoms or evidence of liver injury. in patients with acquired immune deficiency syndrome, hepatic involvement of ks is present in 12%-24% of the population on incidental imaging and in approxi ... | 2017 | 28217255 |
| developmental therapeutics implications of next-generation sequencing in human herpesvirus 8-negative castleman disease. | 2017 | 28241212 | |
| kshv-associated and ebv-associated germinotropic lymphoproliferative disorder: new findings and review of the literature. | we report 2 cases of kaposi sarcoma-associated herpesvirus (kshv)-and epstein-barr virus (ebv) associated germinotropic lymphoproliferative disorder. both cases arose in patients from regions endemic for kshv, cape verde, and the democratic republic of the congo, presenting as localized lymphadenopathy. the affected lymph nodes showed colonization of the follicles by clusters of large atypical plasmablasts, but also showed regressive changes with vascular proliferation and interfollicular plasma ... | 2017 | 28248818 |
| novel chemokine-based immunotoxins for potent and selective targeting of cytomegalovirus infected cells. | immunotoxins as antiviral therapeutics are largely unexplored but have promising prospective due to their high selectivity potential and their unparalleled efficiency. one recent example targeted the virus-encoded g protein-coupled receptor us28 as a strategy for specific and efficient treatment of human cytomegalovirus (hcmv) infections. us28 is expressed on virus-infected cells and scavenge chemokines by rapid internalization. the chemokine-based fusion-toxin protein (ftp) consisted of a varia ... | 2017 | 28251165 |
| seroprevalence of kaposi's sarcoma-associated herpesvirus among hiv-infected uygurs in xinjiang, china. | kaposi's sarcoma-associated herpesvirus (kshv) is the etiological agent of kaposi's sarcoma (ks), which primarily affects human immunodeficiency virus (hiv)-infected adults with advanced immunodeficiency. xinjiang province in china is an endemic area for kaposi's sarcoma (ks), however, currently, only limited prevalence data for kshv infection in hiv-infected individuals living in this endemic area is available. a cross-sectional study of 86 hiv positive participants was conducted in xinjiang, c ... | 2017 | 28252177 |
| integrated systems biology analysis of kshv latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism. | kaposi's sarcoma associated herpesvirus (kshv), an oncogenic, human gamma-herpesvirus, is the etiological agent of kaposi's sarcoma the most common tumor of aids patients world-wide. kshv is predominantly latent in the main ks tumor cell, the spindle cell, a cell of endothelial origin. kshv modulates numerous host cell-signaling pathways to activate endothelial cells including major metabolic pathways involved in lipid metabolism. to identify the underlying cellular mechanisms of kshv alteration ... | 2017 | 28257516 |
| kshv micrornas: tricks of the devil. | kaposi's sarcoma-associated herpesvirus (kshv) is the etiologic agent of kaposi's sarcoma (ks), a vascular tumor frequently found in immunodeficient individuals. kshv encodes 12 pre-micrornas (pre-mirnas), which are processed into 25 mature micrornas (mirnas). kshv mirnas maintain kshv latency, enhance angiogenesis and dissemination of the infected cells, and interfere with the host immune system by regulating viral and cellular gene expression, ultimately contributing to ks development. in this ... | 2017 | 28259385 |
| endoscopic appearance of oropharyngeal and upper gi kaposi's sarcoma in an immunocompromised patient. | introduction. kaposi's sarcoma (ks) usually manifests as a cutaneous disease but gi manifestation is often rare. it is associated with human herpes virus-8 (hhv-8) and seen in immunocompromised patients. in the usa, use of highly active antiretroviral therapy (haart) has drastically reduced incidence of ks in hiv patients. case presentation. a 65-year-old male with human immunodeficiency virus (hiv) was admitted to the intensive care unit (icu) with cardiopulmonary arrest secondary to hyperkalem ... | 2017 | 28261507 |
| kaposi's sarcoma after t-cell costimulation blockade with abatacept in rheumatoid arthritis: a case report. | kaposi's sarcoma (ks) is a malignant neoplasm caused by hhv-8, a pathogen that leads to endothelial cell transformation when host defences are weakened. | 2017 | 28262965 |
| glycolysis, glutaminolysis and fatty acid synthesis are required for distinct stages of kshv lytic replication. | kaposi's sarcoma-associated herpesvirus (kshv) is the etiologic agent of kaposi's sarcoma (ks). kshv infection induces and requires multiple metabolic pathways, including glycolysis, glutaminolysis and fatty acid synthesis (fas) for the survival of latently infected endothelial cells. to determine the metabolic requirements for productive kshv infection, we induced lytic replication in the presence of inhibitors of different metabolic pathways. we found that glycolysis, glutaminolysis and fas ar ... | 2017 | 28275189 |
| establishment of multiplex solid-phase strip pcr test for detection of 24 ocular infectious disease pathogens. | to establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip pcr) for concurrent detection of common ocular infectious disease pathogens. | 2017 | 28282487 |
| modulation of oncogenic signaling networks by kaposi's sarcoma-associated herpesvirus. | kaposi's sarcoma-associated herpesvirus (kshv) is the etiological agent of three human malignancies: kaposi's sarcoma, primary effusion lymphoma, and multicentric castleman's disease. to persist and replicate within host cells, kshv encodes proteins that modulate different signaling pathways. manipulation of cell survival and proliferative networks by kshv can promote the development of kshv-associated malignancies. in this review, we discuss recent updates on kshv pathogenesis and the viral lif ... | 2017 | 28284028 |
| acquired immune deficiency syndrome-associated kaposi sarcoma in a child presenting as a solitary plantar hyperkeratotic plaque. | acquired immune deficiency syndrome (aids)-associated kaposi sarcoma (ks) among the pediatric population is a rare entity in north america and europe, and its cutaneous manifestations are not well defined in the literature. the investigators report the case of a boy with an aids-associated ks presenting as an infiltrated hyperkeratotic plaque of the plantar arch. | 2017 | 28288525 |
| increased frequency and vasculogenic potential of endothelial colony-forming cells in patients with kaposi's sarcoma. | kaposi's sarcoma (ks) is characterized by hyperproliferation of spindle cells that have an endothelial origin and assume their characteristic features upon infection with human herpesvirus-8 (hhv8), the causative agent for ks. the multifocal nature of ks suggests that spindle cells derive from circulating hhv8-infected precursors that yet lack identification. we investigated whether ecfcs obtained from ks patients may be putative precursors of spindle cells, by assessing whether their in vitro b ... | 2017 | 28288847 |
| mycosis fungoides and kaposi's sarcoma association in an hiv-negative patient. | the association of mycosis fungoides and kaposi's sarcoma in hiv-negative patients is a rare phenomenon. the presence of human herpesvirus 8 (hhv-8) - associated with all forms of kaposi's sarcoma - has also been recently identified in mycosis fungoides lesions. however, a causal association between hhv-8 and the onset of mycosis fungoides has not been established yet. the present case reports a patient who developed kaposi's sarcoma lesions after a two-year uvb phototherapy to treat a mycosis f ... | 2017 | 28300912 |
| mediastinal syndrome from plasmablastic lymphoma in human immunodeficiency virus and human herpes virus 8 negative patient with polycythemia vera: a case report. | plasmoblastic lymphoma is a rare and aggressive subtype of diffuse large b cell lymphoma, which occurs usually in the jaw of immunocompromised subjects. | 2017 | 28320457 |
| long-term nitrite inhalant exposure and cancer risk in men who have sex with men: a prospective cohort study. | nitrite inhalants (poppers) are commonly used recreational drugs among men who have sex with men (msm) and were previously associated with elevated rates of high-risk sexual behavior, hiv and hhv-8 seroconversion, and transient immunosuppressive effects in experimental models. whether long-term popper use is associated with cancer risk among msm in the haart era is unclear. | 2017 | 28323751 |
| diagnosis and treatment of kaposi sarcoma. | kaposi sarcoma (ks) is the most common neoplasm of people living with hiv today. in sub-saharan africa, ks is among the most common cancers in men, overall. not only hiv-positive individuals present with ks; any immune compromised person infected with ks-associated herpesvirus (kshv) or human herpesvirus 8 is at risk: the elderly, children in kshv-endemic areas, and transplant recipients. ks diagnosis is based on detection of the viral protein latency-associated nuclear antigen (lana) in the bio ... | 2017 | 28324233 |
| classic kaposi sarcoma in an hiv-negative han chinese man: a case report. | kaposi sarcoma (ks) is a multifocal angioproliferativetumor of endothelial origin. despite nearly identicalclinical and histopathologic presentations, ks isclassified into four distinct varieties: classic/sporadic,aids-associated, african/endemic, and iatrogenic. allsubtypes are invariably linked to human herpesvirus-8(hhv-8) and show a male predilection. classic kaposisarcoma is exceedingly rare in the asian populationand its incidence varies by region and ethnic grouppredominance. a study in t ... | 2017 | 28329475 |
| kaposi's sarcoma in an hiv-negative patient. | we report an hiv-negative, 55-year-old manwith recurrent kaposi's sarcoma (ks) of the lowerextremities, who does not fit into any of thefour previously described variants of ks: classicks, aids-related ks, iatrogenic ks, and africanendemicks. there are reports in the literature ofchildhood-onset ks, which is thought to be dueto an inherited immune deficiency that confers ahigher susceptibility to human herpesvirus-8 (hhv-8), which is the virus that is known to cause ks. ourpatient may be affecte ... | 2016 | 28329535 |
| kaposi's sarcoma-associated herpesvirus hijacks rna polymerase ii to create a viral transcriptional factory. | locally concentrated nuclear factors ensure efficient binding to dna templates, facilitating rna polymerase ii recruitment and frequent reutilization of stable preinitiation complexes. we have uncovered a mechanism for effective viral transcription by focal assembly of rna polymerase ii around kaposi's sarcoma-associated herpesvirus (kshv) genomes in the host cell nucleus. using immunofluorescence labeling of latent nuclear antigen (lana) protein, together with fluorescence in situ rna hybridiza ... | 2017 | 28331082 |
| multicenter prospective study for laboratory diagnosis of hhv8 infection in solid organ donors and transplant recipients and evaluation of the clinical impact after transplantation. | we performed serological and molecular pretransplant screening in solid organ transplant (sot) donors and recipients in north-central italy and a surveillance program for human herpes virus 8 (hhv8) infection after transplant, aiming to establish an optimal management of hhv8 infection in sot recipients. | 2017 | 28333859 |
| quantitative analysis of the kshv transcriptome following primary infection of blood and lymphatic endothelial cells. | the transcriptome of the kaposi's sarcoma-associated herpesvirus (kshv/hhv8) after primary latent infection of human blood (bec), lymphatic (lec) and immortalized (time) endothelial cells was analyzed using rnaseq, and compared to long-term latency in bcbl-1 lymphoma cells. naturally expressed transcripts were obtained without artificial induction, and a comprehensive annotation of the kshv genome was determined. a set of unique coding sequence (ucds) features and a process to resolve overlappin ... | 2017 | 28335496 |
| kaposi's sarcoma-associated herpesvirus orf34 is essential for late gene expression and virus production. | kaposi's sarcoma-associated herpesvirus (kshv) is the causative agent of kaposi's sarcoma, primary effusion lymphoma, and multicentric castleman's disease. kshv establishes a life-long infection in its host and alternates between a latent and lytic infection state. during lytic infection, lytic-related genes are expressed in a temporal manner and categorized as immediate early, early, and late gene transcripts. orf34 is an early-late gene that interacts with several viral transcription-associate ... | 2017 | 28336944 |
| prevalence of human herpesvirus-8 and bk polyoma virus infections in end-stage renal disease and the influence of renal transplantation. | viral infections lead to significant morbidity and mortality in kidney transplant recipients. we evaluated 49 kidney transplant recipients for human herpesvirus 8 (hhv-8) and bk polyomavirus infections in conjunction with data obtained from 43 donors. the seroprevalence of hhv-8 was 6.9% in donors and 12.2% in recipients. hhv-8 dna was detected below the limit of quantification (<5000 copies/ml) in a recipient with hhv-8 seropositivity at the pretransplant period and was undetectable at month 3 ... | 2017 | 28340807 |
| kshv-encoded viral interferon regulatory factor 4 (virf4) interacts with irf7 and inhibits interferon alpha production. | before an infection can be completely established, the host immediately turns on the innate immune system through activating the interferon (ifn)-mediated antiviral pathway. kaposi's sarcoma-associated herpesvirus (kshv) utilizes a unique antagonistic mechanism of type i ifn-mediated host antiviral immunity by incorporating four viral interferon regulatory factors (virf1-4). herein, we characterized novel immune evasion strategies of virf4 to inhibit the irf7-mediated ifn-α production. kshv virf ... | 2017 | 28342865 |
| human herpesvirus-8 and human cytomegalovirus infections in bowen's disease: is there any association? | 2017 | 28366922 | |
| evidence for a mesothelial origin of body cavity effusion lymphomas. | primary effusion lymphoma (pel) is a kaposi's sarcoma herpes virus (kshv)-induced lymphoma that typically arises in body cavities of hiv-infected patients. pel cells are often co-infected with epstein-barr virus (ebv). "pel-like" lymphoma is a kshv-unrelated lymphoma that arises in body cavities of hiv-negative patients. "pel-like" lymphoma is sometimes ebv positive. the derivation of pel/"pel-like" cells is unclear. | 2017 | 28376153 |
| kaposi's sarcoma-associated herpesvirus polyadenylated nuclear rna: a structural scaffold for nuclear, cytoplasmic and viral proteins. | kaposi's sarcoma-associated herpes virus (kshv) polyadenylated nuclear (pan) rna facilitates lytic infection, modulating the cellular immune response by interacting with viral and cellular proteins and dna. although a number nucleoprotein interactions involving pan have been implicated, our understanding of binding partners and pan rna binding motifs remains incomplete. herein, we used shape-mutational profiling (shape-map) to probe pan in its nuclear, cytoplasmic or viral environments or follow ... | 2017 | 28383682 |
| sirt1 and ampk pathways are essential for the proliferation and survival of primary effusion lymphoma cells. | primary effusion lymphoma (pel) is a rare and aggressive b-cell lymphoma with a dismal prognosis caused by infection of kaposi's sarcoma-associated herpesvirus. despite the findings that numerous viral genes and cellular pathways are essential for the proliferation and survival of pel cells, there is currently no effective therapeutic treatment for pel. here, we report that the metabolic sensor sirt1 is functionally required for sustaining the proliferation and survival of pel cells. knockdown o ... | 2017 | 28393364 |
| molecular mechanisms of activating c-met in kshv+ primary effusion lymphoma. | the oncogenic kaposi's sarcoma-associated herpesvirus (kshv) is a principal causative agent of primary effusion lymphoma (pel), which is mostly seen in immunosuppressed patients. pel is a rapidly progressing malignancy with a median survival time of approximately 6 months even under the conventional chemotherapy. we recently report that the hepatocyte growth factor (hgf)/c-met pathway is highly activated in pel cells and represents a promising therapeutic target (blood. 2015;126(26):2821-31). ho ... | 2017 | 28407694 |
| kaposi sarcoma inflammatory cytokine syndrome (kics): a rare but potentially treatable condition. | kaposi sarcoma inflammatory cytokine syndrome (kics) is a newly-described condition affecting individuals who are hiv-positive and are infected with human herpesvirus 8 (hhv-8). this is a syndrome that in some ways mimics severe sepsis with associated acute respiratory distress syndrome, possibly requiring a ventilator and vasopressor support. however, unlike severe sepsis, antibiotics provide no benefit. management of kics has not been fully elucidated because of its high mortality rate. howeve ... | 2017 | 28424322 |
| disarming cellular alarm systems-manipulation of stress-induced nkg2d ligands by human herpesviruses. | the coevolution of viruses and their hosts led to the repeated emergence of cellular alert signals and viral strategies to counteract them. the herpesvirus family of viruses displays the most sophisticated repertoire of immune escape mechanisms enabling infected cells to evade immune recognition and thereby maintain infection. the herpesvirus family consists of nine viruses that are capable of infecting humans: herpes simplex virus 1 and 2 (hsv-1, hsv-2), varicella zoster virus (vzv), epstein-ba ... | 2017 | 28443092 |
| kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen: replicating and shielding viral dna during viral persistence. | kaposi's sarcoma herpesvirus (kshv) establishes lifelong latency. the viral latency-associated nuclear antigen (lana) promotes viral persistence by tethering the viral genome to cellular chromosomes and by participating in latent dna replication. recently, the structure of the lana c-terminal dna binding domain was solved and new cytoplasmic variants of lana were discovered. we discuss how these findings contribute to our current view of lana structure and assembly and of its role during viral p ... | 2017 | 28446671 |
| primary lymphocyte infection models for kshv and its putative tumorigenesis mechanisms in b cell lymphomas. | kaposi's sarcoma-associated herpesvirus (kshv) is the latest addition to the human herpesvirus family. unlike alpha- and beta-herpesvirus subfamily members, gamma-herpesviruses, including epstein-barr virus (ebv) and kshv, cause various tumors in humans. kshv primarily infects endothelial and b cells in vivo, and is associated with at least three malignancies: kaposi's sarcoma and two b cell lymphomas, respectively. although kshv readily infects endothelial cells in vitro and thus its pathogenic ... | 2017 | 28455586 |
| rhadinoviral interferon regulatory factor homologues. | kaposi's sarcoma-associated herpesvirus (kshv), or human herpesvirus 8 (hhv8) is a gammaherpesvirus and the etiological agent of kaposi's sarcoma, primary effusion lymphoma and multicentric castleman disease. the kshv genome contains genes for a unique group of proteins with homology to cellular interferon regulatory factors, termed viral interferon regulatory factors (virfs). this review will give an overview over the oncogenic, antiapoptotic and immunomodulatory characteristics of kshv and rel ... | 2017 | 28455950 |
| incorporation of the kaposi's sarcoma-associated herpesvirus capsid vertex-specific component (cvsc) into self-assembled capsids. | self-assembly of herpesvirus capsids can be accomplished in heterologous expression systems provided all six capsid proteins are present. we have demonstrated the assembly of icosahedral kaposi's sarcoma-associated herpesvirus (kshv) capsids in insect cells using the baculovirus expression system. using this self-assembly system we investigated whether we could add additional capsid associated proteins and determine their incorporation into the assembled capsid. we chose the capsid vertex-specif ... | 2017 | 28456575 |
| ribonucleotide reductase represents a novel therapeutic target in primary effusion lymphoma. | primary effusion lymphoma (pel) is a highly aggressive b-cell malignancy that is closely associated with one of oncogenic viruses infection, kaposi's sarcoma-associated herpesvirus. pel prognosis is poor and patients barely survive >6 months even following active chemotherapy interventions. there is therefore an urgent need to discover more effective targets for pel management. we recently found that the ribonucleotide reductase (rr) subunit m2 is potentially regulated by the key oncogenic hepat ... | 2017 | 28459467 |
| nlrx1 negatively modulates type i ifn to facilitate kshv reactivation from latency. | kaposi's sarcoma-associated herpesvirus (kshv) is a herpesvirus that is linked to kaposi's sarcoma (ks), primary effusion lymphoma (pel) and multicentric castleman's disease (mcd). kshv establishes persistent latent infection in the human host. kshv undergoes periods of spontaneous reactivation where it can enter the lytic replication phase of its lifecycle. during kshv reactivation, host innate immune responses are activated to restrict viral replication. here, we report that nlrx1, a negative ... | 2017 | 28459883 |
| reactivation and lytic replication of kaposi's sarcoma-associated herpesvirus: an update. | the life cycle of kaposi's sarcoma-associated herpesvirus (kshv) consists of two phases, latent and lytic. the virus establishes latency as a strategy for avoiding host immune surveillance and fusing symbiotically with the host for lifetime persistent infection. however, latency can be disrupted and kshv is reactivated for entry into the lytic replication. viral lytic replication is crucial for efficient dissemination from its long-term reservoir to the sites of disease and for the spread of the ... | 2017 | 28473805 |
| successful treatment of kaposi sarcoma-associated herpesvirus inflammatory cytokine syndrome after kidney-liver transplant: correlations with the human herpesvirus 8 mirnome and specific t cell response. | after transplant, patient infection with human herpesvirus 8 (hhv-8) and kaposi sarcoma-associated herpesvirus (kshv) is known to cause aggressive tumors and severe nonneoplastic complications. these latter syndromes are driven by hhv-8/kshv lytic reactivations and related hyperinflammatory host responses typically characterized by high viral loads, elevated levels of cytokines and other inflammation biomarkers, cytopenia, organ failure, high fever, and worsening conditions (with no evidence of ... | 2017 | 28489271 |
| epstein-barr virus rta-mediated accumulation of dna methylation interferes with ctcf binding in both host and viral genomes. | rta, an epstein-barr virus (ebv) immediate-early protein, reactivates viral lytic replication that is closely associated with tumorigenesis. in previous studies, we demonstrated that in epithelial cells rta efficiently induced cellular senescence, which is an irreversible g1 arrest likely to provide a favorable environment for productive replications of ebv and kaposi's sarcoma-associated herpesvirus (kshv). to restrict progression of the cell cycle, rta simultaneously upregulates cdk inhibitors ... | 2017 | 28490592 |
| multicentric castleman disease of hyaline vascular variant presenting with unusual systemic manifestations: a case report. | castleman disease is a rare lymphoproliferative disorder presenting with localized or disseminated lymphadenopathy and systemic manifestations. it can be categorized in numerous ways, such as unicentric versus multicentric, histopathological variants (hyaline-vascular, plasma cell, and mixed), or subtypes based on causative viral infections (human immunodeficiency virus, human herpesvirus-8, or kaposi sarcoma herpesvirus). presentation ranges from asymptomatic to symptoms involving multiple orga ... | 2017 | 28501028 |
| human herpesvirus 8-related diseases: histopathologic diagnosis and disease mechanisms. | the emergence of hiv/aids more than three decades ago led to an increased incidence of diseases caused by hhv8 co-infection, particularly kaposi sarcoma, primary effusion lymphoma, and multicentric castleman disease. over time, the development of highly effective aids therapies has resulted in a decreased incidence of hhv8-associated entities, which are now more commonly found in patients with undiagnosed and/or untreated aids. due to their rarity, some of these diseases may be difficult to reco ... | 2017 | 28502522 |
| virus-like vesicles of kaposi's sarcoma-associated herpesvirus activate lytic replication by triggering differentiation signaling. | virus-like vesicles (vlvs) are membrane-enclosed vesicles that resemble native enveloped viruses in organization but lack the viral capsid and genome. during the productive infection of tumor-associated gammaherpesviruses, both virions and vlvs are produced and are released into the extracellular space. however, studies of gammaherpesvirus-associated vlvs have been largely restricted by the technical difficulty of separating vlvs from mature virions. here we report a strategy of selectively isol ... | 2017 | 28515293 |
| comparison of kaposi sarcoma risk in hiv-positive adults across five continents: a multiregional multicohort study. | we compared kaposi sarcoma (ks) risk in adults who initiated antiretroviral therapy (art) across the asia-pacific, south africa, europe, latin, and north america. | 2017 | 28531260 |
| seroprevalence of antibodies against kaposi's sarcoma-associated herpesvirus among hiv-negative people in china. | little information on the prevalence of kaposi's sarcoma associated herpesvirus (kshv) among hiv-negative individuals is available from asia. | 2017 | 28572838 |
| case report of a primary effusion lymphoma successfully treated with oral valganciclovir after failing chemotherapy. | primary effusion lymphoma is a rare non-hodgkin lymphoma that presents with pleural effusions and lacking of tumour mass. it is universally associated with human herpesvirus 8 (hhv8) and is more frequent among immunosuppressed patients. there is no standard treatment, chemotherapy and anti-hiv therapy have been used with poor results, but there is still no strong evidence supporting the use of valganciclovir. we present the case of a hiv positive man that presented with pleural effusion compatib ... | 2017 | 28580733 |
| guanylate-binding protein 1 inhibits nuclear delivery of kaposi's sarcoma-associated herpesvirus virions by disrupting formation of actin filament. | kaposi's sarcoma-associated herpesvirus (kshv) is a typical gammaherpesvirus that establishes persistent lifelong infection in host cells. in order to establish successful infection, kshv has evolved numerous immune evasion strategies to bypass or hijack the host immune system. however, host cells still produce immune cytokines abundantly during primary kshv infection. whether the immune effectors produced are able to inhibit viral infection and how kshv successfully conquers these immune effect ... | 2017 | 28592529 |
| kaposi's sarcoma-associated herpesvirus utilizes and manipulates rna n(6)-adenosine methylation to promote lytic replication. | n(6)-adenosine methylation (m(6)a) is the most common posttranscriptional rna modification in mammalian cells. we found that most transcripts encoded by the kaposi's sarcoma-associated herpesvirus (kshv) genome undergo m(6)a modification. the levels of m(6)a-modified mrnas increased substantially upon stimulation for lytic replication. the blockage of m(6)a inhibited splicing of the pre-mrna encoding the replication transcription activator (rta), a key kshv lytic switch protein, and halted viral ... | 2017 | 28592530 |
| functional dissection of human targets for kshv-encoded mirnas using network analysis. | kaposi's sarcoma-associated herpesvirus (kshv) is the etiological agent of kaposi's sarcoma, primary effusion lymphoma and multicentric castleman's disease, etc. in this study, we firstly systematically constructed the kshv-encoded mirna-regulated co-expressed protein-protein interaction network (ceppin), which display the biological knowledge regarding the mechanism of mirna-regulated kshv pathogenesis. then, we investigated the topological parameters for the proteins in ceppin, especially for ... | 2017 | 28600495 |
| an easily transfectable cell line that produces an infectious reporter virus for routine and robust quantitation of kaposi's sarcoma-associated herpesvirus reactivation. | reactivation of kaposi's sarcoma-associated herpesvirus (khsv; also known as human herpesvirus (hhv)-8) from latency is associated with progression to disease. the primary experimental models for studying kshv reactivation are b lymphocyte cell lines derived from patients with primary effusion lymphoma (pel). pel models have remained essential tools for understanding molecular details of latency and reactivation, yet they have shortcomings. in particular, pel cells are difficult to transfect wit ... | 2017 | 28602767 |
| high seroprevalence of human herpesvirus 8 infection in hiv-positive homosexual men in jiangsu province, china. | hiv-infected homosexual men are more frequently diagnosed with kaposi's sarcoma. with the increase of hiv-infected homosexual men in china, we urgently need to know the ks-related human herpesvirus (kshv/hhv-8) seroprevalence in this population. to investigate the hhv-8 prevalence among hiv-positive homosexual men, we recruited 183 patients naive of antiretroviral therapy (art) whose blood samples present hiv-antibody positive confirmed by western blot. | 2017 | 28606034 |
| hiv-associated kaposi sarcoma and related diseases. | : the search for the etiologic agent for kaposi sarcoma led to the discovery of kaposi sarcoma-associated herpesvirus (kshv) in 1994. kshv, also called human herpesvirus-8, has since been shown to be the etiologic agent for several other tumors and diseases, including primary effusion lymphoma (pel), an extracavitary variant of pel, kshv-associated diffuse large b-cell lymphoma, a form of multicentric castleman disease, and kshv inflammatory cytokine syndrome. kshv encodes several genes that int ... | 2017 | 28609402 |
| lymphoproliferative disorders of the lung. | this review aims to describe some of the most frequent lymphoproliferative disorders arising from the lung: pulmonary mucosa-associated lymphoid tissue (malt) lymphoma, lymphomatoid granulomatosis (lg), multicentric castleman disease (mcd), primary effusion lymphoma (pel), and nodular lymphoid hyperplasia (nlh). primary pulmonary lymphoma is defined as a clonal lymphoproliferative disorder affecting one or both lungs, without extrapulmonary involvement 3 months after diagnosis, and includes pulm ... | 2017 | 28609772 |
| antimicrobial sulfonamides clear latent kaposi sarcoma herpesvirus infection and impair mdm2-p53 complex formation. | kaposi sarcoma herpesvirus (kshv), also known as human herpesvirus 8, is the causative agent of kaposi sarcoma; this malignant angiosarcoma is usually treated with conventional antitumor agents that can control disease evolution, but do not clear the latent kshv episome that binds to cellular dna. some commercial antibacterial sulfonamides were tested for the ability to suppress latent kshv. quantitative pcr (qpcr) and cytofluorometry assays were used for detecting both viral dna and the latency ... | 2017 | 28611469 |
| the latency-associated nuclear antigen of kaposi's sarcoma-associated herpesvirus inhibits expression of sumo/sentrin-specific peptidase 6 to facilitate establishment of latency. | kaposi's sarcoma-associated herpesvirus (kshv), which belongs to the gammaherpesviridae, typically displays two different phases in its life cycle, the latent phase and the lytic phase. latency-associated nuclear antigen (lana), the primary viral product during latency, has been reported to bind to a series of cellular gene promoters to modulate gene transcription. to systemically elucidate the cellular genes regulated by lana, we identified genome-wide lana binding sites by chromatin immunoprec ... | 2017 | 28615201 |
| a conserved leucine zipper motif in gammaherpesvirus orf52 is critical for distinct microtubule rearrangements. | productive viral infection often depends on the manipulation of the cytoskeleton. herpesviruses, including rhesus monkey rhadinovirus (rrv) and its close homolog, the oncogenic human gammaherpesvirus kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (kshv/hhv8), exploit microtubule (mt)-based retrograde transport to deliver their genomes to the nucleus. subsequently, during the lytic phase of the life cycle, the maturing viral particles undergo orchestrated translocation to specialized ... | 2017 | 28615210 |
| diversity of human herpesvirus 8 genotypes in patients with aids and non-aids associated kaposi's sarcoma, castleman's disease and primary effusion lymphoma in argentina. | hhv-8 genotypes are distributed heterogeneously worldwide. the variable k1 gene and the conserved orf26e region serve to genotype. the aim of the study was to characterize hhv-8 isolates from patients with aids, classical, and iatrogenic ks, primary effusion lymphoma and castleman's disease and one organ donor from argentina by analysis of orfk1 and orf26e regions. dna was extracted from fresh or paraffin embedded biopsies, blood, and saliva samples and submitted to hhv-8 pcr. phylogenetic analy ... | 2017 | 28617968 |
| no detectable human herpesvirus-8 oral shedding in seronegative-healthy, immunocompetent individuals from non-endemic regions for kaposi's sarcoma: a pilot study. | saliva can play an important role in human herpesvirus-8 (hhv-8) transmission in endemic regions for kaposi's sarcoma (ks). little is known about hhv-8 oral shedding in immunocompetent individuals from non-endemic regions for ks. | 2017 | 28631891 |
| modulation of global sumoylation by kaposi's sarcoma-associated herpesvirus and its effects on viral gene expression. | some viruses have evolved to exploit the host sumoylation system to regulate their own replication. kaposi's sarcoma-associated herpesvirus (kshv) encodes k-bzip, a sumo e3 ligase catalyzing the sumoylation of viral and host proteins. kshv also encodes replication and transcriptional activator (rta), a sumo-targeted ubiquitin ligase catalyzing the ubiquitination of sumoylated proteins and targeting them for degradation. using chronic kshv-infected tre × bcbl-1 rta cells, the expression kinetics ... | 2017 | 28639696 |
| effect of electrochemotherapy on human herpesvirus 8 kinetics in classic kaposi sarcoma. | electrochemotherapy (ect) has shown to be an effective treatment for cutaneous and subcutaneous kaposi sarcoma (ks) lesions. however, no study has investigated the impact of ect treatment on the kinetics of human herpesvirus type 8 (hhv8), which is considered the necessary causal agent of ks. we aimed to evaluate hhv8 viral load and expression levels in patients affected by classic ks who received one or more ect treatments and have been followed semi annually for up to four years. | 2017 | 28649271 |
| post-transplant lymphoproliferative disorder presented in a form of primary effusion lymphoma with t (8; 14). | post-transplant lymphoproliferative disorders (ptld) are emergent complications of organ transplantation occurring in 2% to 10% of transplanted patients. epstein-barr virus (ebv) infections are considered the most important factors for the development of these heterogeneous disorders. primary effusion lymphoma (pel) is a lymphoproliferative disorder predominantly described in patients with advanced aids and it is almost universally associated with human herpesvirus 8 (hhv8). in rare case, pel al ... | 2017 | 28667038 |
| kshv encoded orf59 modulates histone arginine methylation of the viral genome to promote viral reactivation. | kaposi's sarcoma associated herpesvirus (kshv) persists in a highly-ordered chromatin structure inside latently infected cells with the majority of the viral genome having repressive marks. however, upon reactivation the viral chromatin landscape changes into 'open' chromatin through the involvement of lysine demethylases and methyltransferases. besides methylation of lysine residues of histone h3, arginine methylation of histone h4 plays an important role in controlling the compactness of the c ... | 2017 | 28678843 |
| inhibition of highly pathogenic avian influenza (hpai) virus by a peptide derived from vflip through its direct destabilization of viruses. | the antiviral activities of synthesized kα2-helix peptide, which was derived from the viral flice-like inhibitor protein (vflip) of kaposi's sarcoma-associated herpesvirus (kshv), against influenza a virus (iav) were investigated in vitro and in vivo, and mechanisms of action were suggested. in addition to the robust autophagy activity of the kα2-helix peptide, the present study showed that treatment with the kα2 peptide fused with the tat peptide significantly inhibited iav replication and tran ... | 2017 | 28687749 |
| was kaposi's sarcoma-associated herpesvirus introduced into china via the ancient silk road? an evolutionary perspective. | kaposi's sarcoma-associated herpesvirus (kshv) has become widely dispersed worldwide since it was first reported in 1994, but the seroprevalence of kshv varies geographically. kshv is relatively ubiquitous in mediterranean areas and the xinjiang uygur autonomous region, china. the origin of kshv has long been puzzling. in the present study, we collected and analysed 154 kshv orf-k1 sequences obtained from samples originating from xinjiang, italy, greece, iran and southern siberia using bayesian ... | 2017 | 28687922 |
| a tiny rna that packs a big punch: the critical role of a viral mir-155 ortholog in lymphomagenesis in marek's disease. | micrornas (mirnas) are small non-coding rnas that have been identified in animals, plants, and viruses. these small rnas play important roles in post-transcriptional regulation of various cellular processes, including development, differentiation, and all aspects of cancer biology. rapid-onset t-cell lymphoma of chickens, namely marek's disease (md), induced by gallid alphaherpesvirus 2 (gahv2), could provide an ideal natural animal model for herpesvirus-related cancer research. gahv2 encodes 26 ... | 2017 | 28694799 |
| kaposi's sarcoma-associated herpesvirus stably clusters its genomes across generations to maintain itself extrachromosomally. | genetic elements that replicate extrachromosomally are rare in mammals; however, several human tumor viruses, including the papillomaviruses and the gammaherpesviruses, maintain their plasmid genomes by tethering them to cellular chromosomes. we have uncovered an unprecedented mechanism of viral replication: kaposi's sarcoma-associated herpesvirus (kshv) stably clusters its genomes across generations to maintain itself extrachromosomally. to identify and characterize this mechanism, we developed ... | 2017 | 28696226 |
| viral micrornas repress the cholesterol pathway, and 25-hydroxycholesterol inhibits infection. | from various screens, we found that kaposi's sarcoma-associated herpesvirus (kshv) viral micrornas (mirnas) target several enzymes in the mevalonate/cholesterol pathway. 3-hydroxy-3-methylglutaryl-coenzyme a (coa) synthase 1 (hmgcs1), 3-hydroxy-3-methylglutaryl-coa reductase (hmgcr [a rate-limiting step in the mevalonate pathway]), and farnesyl-diphosphate farnesyltransferase 1 (fdft1 [a committed step in the cholesterol branch]) are repressed by multiple kshv mirnas. transfection of viral mirna ... | 2017 | 28698273 |
| effects of the nedd8-activating enzyme inhibitor mln4924 on lytic reactivation of kaposi's sarcoma-associated herpesvirus. | the switch of kaposi's sarcoma-associated herpesvirus (kshv) from latency to lytic replication is a key event for viral dissemination and pathogenesis. mln4924, a novel neddylation inhibitor, reportedly causes the onset of kshv reactivation but impairs later phases of viral lytic program in infected cells. thus far, the molecular mechanism involved in the modulation of kshv lytic cycle by mln4924 is not yet fully understood. here, we confirmed that treatment of different kshv-infected primary ef ... | 2017 | 28701396 |
| profiling of cellular microrna responses during the early stages of kshv infection. | kaposi's sarcoma-associated herpesvirus (kshv) causes a variety of cancers, including kaposi's sarcoma (ks), primary effusion lymphoma (pel), and multicentric castleman disease (mcd). host cellular micrornas (mirnas) play important post-transcriptional regulatory roles in gene expression and can greatly influence virus-host cell interactions. this study investigated cellular mirna expression profiles operating in response to early stages of kshv infection of human burkitt lymphoma b cells (bjab) ... | 2017 | 28707270 |
| microrna dependent and independent deregulation of long non-coding rnas by an oncogenic herpesvirus. | kaposi's sarcoma (ks) is a highly prevalent cancer in aids patients, especially in sub-saharan africa. kaposi's sarcoma-associated herpesvirus (kshv) is the etiological agent of ks and other cancers like primary effusion lymphoma (pel). in ks and pel, all tumors harbor latent kshv episomes and express latency-associated viral proteins and micrornas (mirnas). the exact molecular mechanisms by which latent kshv drives tumorigenesis are not completely understood. recent developments have highlighte ... | 2017 | 28715488 |
| de novo human herpesvirus 8 tumors induced by rituximab in autoimmune or inflammatory systemic diseases. | human herpesvirus 8 (hhv-8), also known as kaposi's sarcoma (ks)-associated herpesvirus, is involved in ks and other tumors, including multicentric castleman's disease and primary effusion lymphoma. rituximab (rtx) is currently used for the treatment of several autoimmune or inflammatory diseases and humoral organ transplant rejection. de novo hhv-8 tumors induced by rtx used for these indications have not been reported previously. this study was undertaken to evaluate de novo hhv-8 tumors induc ... | 2017 | 28719723 |
| kaposi's sarcoma-associated herpesvirus infection promotes differentiation and polarization of monocytes into tumor-associated macrophages. | tumor associated macrophages (tams) promote angiogenesis, tumor invasion and metastasis, and suppression of anti-tumor immunity. these myeloid cells originate from monocytes, which differentiate into tams upon exposure to the local tumor microenvironment. we previously reported that kaposi's sarcoma-associated herpes virus (kshv) infection of endothelial cells induces the cytokine angiopoietin-2 (ang-2) to promote migration of monocytes into tumors. here we report that kshv infection of endothel ... | 2017 | 28750175 |
| assemblins as maturational proteases in herpesviruses. | during assembly of herpesvirus capsids, a protein scaffold self-assembles to ring-like structures forming the scaffold of the spherical procapsids. proteolytic activity of the herpesvirus maturational protease causes structural changes that result in angularization of the capsids. in those mature icosahedral capsids, the packaging of viral dna into the capsids can take place. the strictly regulated protease is called assemblin. it is inactive in its monomeric state and activated by dimerization. ... | 2017 | 28758622 |
| allosteric inhibitors, crystallography, and comparative analysis reveal network of coordinated movement across human herpesvirus proteases. | targeting of cryptic binding sites represents an attractive but underexplored approach to modulating protein function with small molecules. using the dimeric protease (pr) from kaposi's sarcoma-associated herpesvirus (kshv) as a model system, we sought to dissect a putative allosteric network linking a cryptic site at the dimerization interface to enzyme function. five cryogenic x-ray structures were solved of the monomeric protease with allosteric inhibitors bound to the dimer interface site. d ... | 2017 | 28759216 |
| human herpesvirus 8 infects and replicates in langerhans cells and interstitial dermal dendritic cells and impairs their function. | the predominant types of dendritic cells (dc) in the skin and mucosa are langerhans cells (lc) and interstitial dermal dc (iddc). lc and iddc process cutaneous antigens and migrate out of the skin and mucosa to the draining lymph nodes to present antigens to t and b cells. because of the strategic location of lc and iddc and the ability of these cells to capture and process pathogens, we hypothesized that they could be infected with human herpesvirus 8 (hhv-8; kaposi's sarcoma-associated herpesv ... | 2017 | 28768873 |
| herpesviral micrornas in cellular metabolism and immune responses. | the micrornas (mirnas) function as a key regulator in many biological processes through post-transcriptional suppression of messenger rnas. recent advancements have revealed that mirnas are involved in many biological functions of cells. not only host cells, but also some viruses encode mirnas in their genomes. viral mirnas regulate cell proliferation, differentiation, apoptosis, and the cell cycle to establish infection and produce viral progeny. particularly, mirnas encoded by herpes virus fam ... | 2017 | 28769892 |
| kshv and the role of notch receptor dysregulation in disease progression. | kaposi's sarcoma-associated herpesvirus (kshv) is the causative agent of two human cancers, kaposi's sarcoma (ks) and primary effusion lymphoma (pel), and a lymphoproliferation, multicentric castleman's disease (mcd). progression to tumor development in ks is dependent upon the reactivation of the virus from its latent state. we, and others, have shown that the replication and transcriptional activator (rta) protein is the only viral gene product that is necessary and sufficient for viral reacti ... | 2017 | 28777778 |
| kshv and the role of notch receptor dysregulation in disease progression. | kaposi's sarcoma-associated herpesvirus (kshv) is the causative agent of two human cancers, kaposi's sarcoma (ks) and primary effusion lymphoma (pel), and a lymphoproliferation, multicentric castleman's disease (mcd). progression to tumor development in ks is dependent upon the reactivation of the virus from its latent state. we, and others, have shown that the replication and transcriptional activator (rta) protein is the only viral gene product that is necessary and sufficient for viral reacti ... | 2017 | 28788110 |
| rutamarin, an active constituent from ruta angustifolia pers., induced apoptotic cell death in the ht29 colon adenocarcinoma cell line. | ruta angustifolia pers. is a perennial herb that is cultivated worldwide, including southeast asia, for the treatment of various diseases as traditional medicine. | 2017 | 28808378 |
| a critical role of glutamine and asparagine γ-nitrogen in nucleotide biosynthesis in cancer cells hijacked by an oncogenic virus. | while glutamine is a nonessential amino acid that can be synthesized from glucose, some cancer cells primarily depend on glutamine for their growth, proliferation, and survival. numerous types of cancer also depend on asparagine for cell proliferation. the underlying mechanisms of the glutamine and asparagine requirement in cancer cells in different contexts remain unclear. in this study, we show that the oncogenic virus kaposi's sarcoma-associated herpesvirus (kshv) accelerates the glutamine me ... | 2017 | 28811348 |
| biophysical and computational studies of the vcci:vmip-ii complex. | certain viruses have the ability to subvert the mammalian immune response, including interference in the chemokine system. poxviruses produce the chemokine binding protein vcci (viral cc chemokine inhibitor; also called 35k), which tightly binds to cc chemokines. to facilitate the study of vcci, we first provide a protocol to produce folded vcci from escherichia coli (e. coli.) it is shown here that vcci binds with unusually high affinity to viral macrophage inflammatory protein-ii (vmip-ii), a ... | 2017 | 28813018 |
| how herpesviruses pass on their genomes. | herpesvirus genomes exist and replicate as episomes inside the host cell nucleus during latent infection. chiu et al. (2017. j. cell biol. https://doi.org/10.1083/jcb.201702013) find that unlike epstein-barr virus, which partitions viral genomes faithfully during cell division, kaposi's sarcoma-associated herpesvirus clusters viral genomes into loci that are distributed unequally to daughter cells. | 2017 | 28819012 |
| outcome of second kidney transplantation in patients with previous post-transplantation kaposi's sarcoma: a french retrospective study. | this retrospective study concerned 8 patients with post-transplantation kaposi's sarcoma (pt-ks) after a first kidney transplant who later had a second kidney transplantation. pt-ks was widespread, with lymph node or visceral involvement in 7 cases. complete remission was observed in 6 cases and partial remission in 2. after the second kidney transplantation, only 2 cases showed recurrence of skin ks, one with previous complete remission of ks and one with partial remission. the mean delay betwe ... | 2017 | 28833536 |
| herpesviruses excretion in saliva of pediatric transplant recipients. | saliva samples could be used for follow-up of herpesviruses infection in the pediatric transplant recipients. | 2017 | 28834054 |
| zic2 is essential for maintenance of latency and is a target of an immediate-early protein during kshv lytic reactivation. | bivalent histone modifications are defined as repressive and activating epigenetic marks that simultaneously decorate the same genomic region. the h3k27me3 mark silences gene expression while h3k4me3 mark prevents the region from becoming permanently silenced and prepares the domain for activation when needed. specific regions of kaposi's sarcoma-associated herpesvirus (kshv) latent episomes are "poised" to be activated by the kshv replication and transcription activator (k-rta). how kshv episom ... | 2017 | 28835494 |