Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| apoptotic effects of the b subunit of bacterial cytolethal distending toxin on the a549 lung cancer cell line. | cytolethal distending toxin (cdt) is a secreted tripartite genotoxin produced by many pathogenic gram-negative bacteria. it is composed of three subunits, cdta, cdtb and cdtc, and cdtb-associated deoxyribonuclease (dnase) activity is essential for the cdt toxicity. in the present study, to design a novel potentially antitumor drug against lung cancer, the possible mechanisms of cdtb anticancer properties were explored in the a549 human lung adenocarcinoma cell line. a recombinant plasmid pcdna3. ... | 2016 | 27165242 |
| [microbiological approach to a possible infective endocarditis case caused by aggregatibacter actinomycetemcomitans]. | aggregatibacter (actinobacillus) actinomycetemcomitans, a small, gram-negative coccobacillus that grows slow and fastidious, is generally colonized in the oral cavity. it is a rarely seen bacterium because of the difficulty of isolation but it can be a causative agent for dental infections and infective endocarditis (ie) particularly in the persons having prosthetic heart valves. in this report, a possible ie case caused by a.actinomycetemcomitans in a patient with aortic valve replacement has b ... | 2016 | 27175505 |
| bactericidal effect of erbium-doped yttrium aluminum garnet laser and photodynamic therapy on aggregatibacter actinomycetemcomitans biofilm on implant surface. | peri-implantitis is a common complication of dental implants. the first step of treatment is elimination of bacterial biofilm and disinfection of the implant surface. this study sought to compare the effects of an erbium-doped yttrium aluminum garnet (er:yag) laser, photodynamic therapy using an indocyanin green-based photosensitizer (icg-based ps) and diode laser, toluidine blue o (tbo) photosensitizer and light-emitting diode (led) light source, and 2% chlorhexidine (chx) on biofilm of aggrega ... | 2017 | 27183085 |
| [use of the real-time pcr for study of the periodontal microbiome in patients with combined pathology of gastroduodenal zone and chronic periodontitis]. | the total of 54 patients with chronic periodontitis of different severity was tested using real-time pcr (dentoflor kit). the group included 38 patients with chronic gastritis. for the first time, a higher prevalence of treponema denticola in periodontium of males in comparison with females was demonstrated. the patients with chronic gastritis had more human genome dna at their periodontium than healthy individuals. non-parametric statistical analysis demonstrated high association of periodontiu ... | 2016 | 27183718 |
| analysis of subgingival plaque ability to stimulate toll-like receptor 2 and 4. | it has been shown that toll-like receptor (tlr) 2- and tlr4-stimulating abilities of supragingival plaque (spp) are associated with periodontal conditions. it is hypothesized that spp might affect the periodontium through its influence on subgingival plaque (sbp). this study investigates relationships between tlr2- and tlr4-stimulating abilities of sbp and periodontal conditions. | 2016 | 27212110 |
| withaferin a inhibits inflammatory responses induced by fusobacterium nucleatum and aggregatibacter actinomycetemcomitans in macrophages. | periodontitis is a progressive chronic inflammatory disease and a major cause of tooth loss in humans. as a withanolides, withaferin a (wa) is known to exhibit strong anti‑inflammatory activity. the present study examined whether wa inhibited inflammatory responses in macrophages in response to two representative periodontal pathogens, fusobacterium nucleatum and aggregatibacter actinomycetemcomitans. murine bone marrow‑derived macrophages (bmdms) were used in this study and cytokine production ... | 2016 | 27220676 |
| sphingosine-1-phosphate receptor 2 regulates proinflammatory cytokine production and osteoclastogenesis. | sphingosine-1-phosphate receptor 2 (s1pr2) couples with the gi, gq, and g12/13 group of proteins, which modulate an array of cellular signaling pathways and affect immune responses to multiple stimuli. in this study, we demonstrated that knockdown of s1pr2 by a specific s1pr2 shrna lentiviral vector significantly inhibited il-1β, il-6, and tnf-α protein levels induced by oral pathogen aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) in murine bone marrow-derived monocytes and mac ... | 2016 | 27224249 |
| influence of aae autotransporter protein on adhesion and biofilm formation by aggregatibacter actinomycetemcomitans. | the periodontopathogen aggregatibacter actinomycetemcomitans colonizes oral cavity by binding to and invading epithelial cells as well as by participating in biofilms formed on hard surfaces. aae, an autotransporter protein, is implicated in bacterial adhesion to epithelial cells. due to the multiple functions of bacterial autotransporter proteins, this study aimed to evaluate the role of aae in a. actinomycetemcomitans ability to adhere to both saliva-coated hydroxyapatite (sha) and biofilm. an ... | 2017 | 27224556 |
| [study of mutual dependence of periodontal and colonic microbiome in health and pathology using nsg-sequencing]. | by using ngs-sequencing libraries of dna from periodontal swabs with primers specific to v6 region of 16s rdna prevalence of bacterial genera and species in periodontal and colonic microbiota of patients with periodontitis of different severity and healthy donors was analyzed. hyper-colonization of the colon with akkermansia muciniphila was found to be the most important maker of negative predisposition to periodontitis (t=133,7 at р=10(-6)). this result is in a good agreement with communication ... | 2016 | 27239990 |
| development of novel electrospun dual-drug fiber mats loaded with a combination of ampicillin and metronidazole. | our study was performed with the aim of preparing electrospun polylactide fibers with a combination of ampicillin (amp) and metronidazole (mnz) and investigating their drug release behavior and the antibacterial effect on aggregatibacter actinomycetemcomitans and other oral pathogens. | 2016 | 27262200 |
| a protein-repellent and antibacterial nanocomposite for class-v restorations to inhibit periodontitis-related pathogens. | the objectives of this study were to develop a bioactive dental composite and investigate the effects of 2-methacryloyloxyethyl phosphorylcholine (mpc) and dimethylaminohexadecyl methacrylate (dmahdm) in class v composite on mechanical properties, water sorption, protein adsorption, and inhibition of four species of periodontitis-related biofilms for the first time. the resin consisted of ethoxylated bisphenol a dimethacrylate (ebpadma) and pyromellitic glycerol dimethacrylate (pmgdm). dmahdm, m ... | 2016 | 27287170 |
| nonsyndromic localized aggressive periodontitis of primary dentition: a rare case report. | periodontitis is an inflammatory disease of the gingiva and tissues of the periodontium. it is characterized by pocket formation and destruction of supporting alveolar bone. periodontal diseases of aggressive nature are not very common in children. they are usually associated with systemic conditions. the present case report is of a 5-year-old male child who reported with rapid attachment loss and bony defects of the gingiva and supporting structures. his family and medical history gave no contr ... | 2016 | 27307682 |
| a modified glycosaminoglycan, gm-0111, inhibits molecular signaling involved in periodontitis. | periodontitis is characterized by microbial infection, inflammation, tissue breakdown, and accelerated loss of alveolar bone matrix. treatment targeting these multiple stages of the disease provides ways to treat or prevent periodontitis. certain glycosaminoglycans (gags) block multiple inflammatory mediators as well as suppress bacterial growth, suggesting that these gags may be exploited as a therapeutic for periodontitis. | 2016 | 27308827 |
| quantitative molecular detection of 19 major pathogens in the interdental biofilm of periodontally healthy young adults. | in oral health, the interdental spaces are a real ecological niche for which the body has few or no alternative defenses and where the traditional daily methods for control by disrupting biofilm are not adequate. the interdental spaces are the source of many hypotheses regarding their potential associations with and/or causes of cardiovascular disease, diabetes, chronic kidney disease, degenerative disease, and depression. this pcr study is the first to describe the interdental microbiota in hea ... | 2016 | 27313576 |
| adjunct antimicrobial therapy and periodontal surgery to treat generalized aggressive periodontitis: a case report. | here we report a case of generalized aggressive periodontitis treated with periodontal therapy including adjunct antimicrobial therapy and periodontal surgery. the patient was a 22-year-old woman who presented with the chief complaint of gingival recession. baseline examination revealed generalized plaque deposition and gingival inflammation. thirty-nine percent of the sites had a probing depth (pd) of 4-6 mm and 2% a pd of ≥7 mm; 63% exhibited bleeding on probing (bop). radiographic examination ... | 2016 | 27320300 |
| periodontopathogens antibodies and major adverse events following an acute myocardial infarction: results from the french registry of acute st-elevation and non-st-elevation myocardial infarction (fast-mi). | periodontopathogens antibodies have been shown to be associated with primary myocardial events, but little is known regarding their impact on major adverse events after a prior acute myocardial infarction (ami). the present prospective study evaluates the association between antibody levels of 4 periodontopathogens and the risk of all-cause death or non-fatal myocardial infarction (mi) at 1 year in 975 patients admitted for acute st segment or non-st segment elevation mi in french registry of ac ... | 2016 | 27325868 |
| an in vitro comparison of antimicrobial effects of curcumin-based photodynamic therapy and chlorhexidine, on aggregatibacter actinomycetemcomitans. | considering the importance of prevention in periodontal diseases and the important role of aggregatibacter actinomycetemcomitans in induction and progression of these diseases, the aim of the present in vitro study was to compare the antimicrobial effects of chlorhexidine digluconate (chx), curcumin and light-emitting diode (led) laser, on this bacterium. | 2016 | 27330693 |
| microbiological efficacy of photodynamic therapy as an adjunct to non-surgical periodontal treatment: a clinical trial. | the efficiency of routine scaling and root planning is negatively influenced by the tooth anatomy and residual bacteria all possibly affecting the treatment outcomes in future. the present study compared the microbiologic effectiveness of the photodynamic therapy (pdt) as an adjunctive treatment modality for nonsurgical treatment in chronic periodontitis. | 2016 | 27330709 |
| periodontitis-associated pathogens p. gingivalis and a. actinomycetemcomitans activate human cd14(+) monocytes leading to enhanced th17/il-17 responses. | the th17/il-17 pathway is implicated in the pathogenesis of periodontitis (pd), however the mechanisms are not fully understood. we investigated the mechanism by which the periodontal pathogens porphyromonas gingivalis (pg) and aggregatibacter actinomycetemcomitans (aa) promote a th17/il-17 response in vitro, and studied il-17(+) cd4(+) t-cell frequencies in gingival tissue and peripheral blood from patients with pd versus periodontally healthy controls. addition of pg or aa to monocyte/cd4(+) t ... | 2016 | 27334899 |
| is mechanical curettage with adjunct photodynamic therapy more effective in the treatment of peri-implantitis than mechanical curettage alone? | the aim of the present study was to review the pertinent literature on the effects of mechanical curettage (mc) with and without adjunct photodynamic therapy (pdt) for the management of peri-implantitis. | 2016 | 27344944 |
| fine-tuned production of hydrogen peroxide promotes biofilm formation of streptococcus parasanguinis by a pathogenic cohabitant aggregatibacter actinomycetemcomitans. | balanced bacterial biofilm communities help to maintain host health. disturbance of such balance can lead to bacterial dysbiosis and pathogenesis. however, complex and dynamic bacterial interactions within the biofilm communities are poorly understood. in this study, we used a dual-species biofilm consisting of the periodontal pathogen aggregatibacter actinomycetemcomitans, and a commensal streptococcus parasanguinis to investigate bacterial interactions since the two organisms have been found t ... | 2016 | 27348605 |
| a commensal bacterium promotes virulence of an opportunistic pathogen via cross-respiration. | bacteria rarely inhabit infection sites alone, instead residing in diverse, multispecies communities. despite this fact, bacterial pathogenesis studies primarily focus on monoculture infections, overlooking how community interactions influence the course of disease. in this study, we used global mutant fitness profiling (transposon sequencing [tn-seq]) to determine the genetic requirements for the pathogenic bacterium aggregatibacter actinomycetemcomitans to cause disease when coinfecting with t ... | 2016 | 27353758 |
| frequency of periodontal pathogens and helicobacter pylori in the mouths and stomachs of obese individuals submitted to bariatric surgery: a cross-sectional study. | this cross-sectional study compared the frequency of oral periodontopathogens and h. pylori in the mouths and stomachs of obese individuals with or without periodontitis submitted to bariatric surgery. | 2016 | 27383704 |
| biofilm formation of periodontal pathogens on hydroxyapatite surfaces: implications for periodontium damage. | biofilm formation of periodontal pathogens on teeth surfaces promotes the progression of periodontal disease. hence, understanding the mechanisms of bacterial attachment to the dental surfaces may inform strategies for the maintenance of oral health. although hydroxyapatite (ha) is a major calcium phosphate component of teeth, effect of biofilm formation on ha surfaces remains poorly characterized. in this study, biofilm-forming abilities by the periodontal pathogens aggregatibacter actinomycete ... | 2016 | 27390886 |
| interactions between lactobacillus rhamnosus gg and oral micro-organisms in an in vitro biofilm model. | probiotics have shown favourable properties in maintaining oral health. by interacting with oral microbial communities, these species could contribute to healthier microbial equilibrium. this study aimed to investigate in vitro the ability of probiotic lactobacillus rhamnosus gg (l.gg) to integrate in oral biofilm and affect its species composition. five oral strains, streptococcus mutans, streptococcus sanguinis, aggregatibacter actinomycetemcomitans, fusobacterium nucleatum and candida albican ... | 2016 | 27405227 |
| antimicrobial effect of platelet-rich plasma and platelet-rich fibrin. | platelet concentrates have been extensively used in a variety of medical fields to promote soft- and hard-tissue regeneration. the significance behind their use lies in the abundance of growth factors (gfs) in platelets α-granules that promote wound healing. other than releasing a pool of gfs upon activation, platelets also have many features that indicate their role in the anti-infective host defense. | 2016 | 27411660 |
| a cytolethal distending toxin variant from aggregatibacter actinomycetemcomitans with an aberrant cdtb that lacks the conserved catalytic histidine 160. | the periodontopathogen aggregatibacter actinomycetemcomitans synthesizes several virulence factors, including cytolethal distending toxin (cdt). the active cdt holoenzyme is an ab-type tripartite genotoxin that affects eukaryotic cells. subunits cdta and cdtc (b-components) allow binding and intracellular translocation of the active cdtb (a-component), which elicits nuclear dna damage. different strains of a. actinomycetemcomitans have diverse virulence genotypes, which results in varied pathoge ... | 2016 | 27414641 |
| impact of cdt toxin on human diseases. | cytolethal distending toxin (cdt) is found in gram-negative bacteria, especially in certain proteobacteria such as the pasteurellaceae family, including haemophilus ducreyi and aggregatibacter (actinobacillus) actinomycetemcomitans, in the enterobacteriaceae family and the campylobacterales order, including the campylobacter and helicobacter species. in vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulatio ... | 2016 | 27429000 |
| mature biofilm degradation by potential probiotics: aggregatibacter actinomycetemcomitans versus lactobacillus spp. | the biofilm degradation of aggregatibacter actinomycetemcomitans is essential as a complete periodontal disease therapy, and here we show the effects of potential probiotic bacteria such as lactobacillus spp. for the biofilm of several serotypes of a. actinomycetemcomitans strains. eight of the 13 species showed the competent biofilm degradation of ≥ 90% reduction in biofilm values in a. actinomycetemcomitans y4 (serotype b) as well as four of the seven species for the biofilm of a. actinomycete ... | 2016 | 27438340 |
| quantifying implant-associated biofilms: comparison of microscopic, microbiologic and biochemical methods. | biofilm-associated infections pose severe problems in modern implant medicine. screening for new implant materials with antibacterial properties requires reliable quantification of colonizing bacteria. there are many different methods to quantify biofilms on solid surfaces in vitro, employing different (bio-)chemical/microbiological reference parameters. it is therefore difficult to compare studies with different quantification techniques. here, we have evaluated commonly used microscopic, micro ... | 2016 | 27444546 |
| a novel intrinsically disordered outer membrane lipoprotein of aggregatibacter actinomycetemcomitans binds various cytokines and plays a role in biofilm response to interleukin-1β and interleukin-8. | intrinsically disordered proteins (idps) do not have a well-defined and stable 3-dimensional fold. some idps can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. a novel outer membrane lipoprotein, bacterial interleukin receptor i (bilri) of the opportunistic oral pathogen aggregatibacter actinomycetemcomitans binds a key gatekeeper proinflammatory cytokine interleukin (il)-1β. because the amino aci ... | 2017 | 27459270 |
| fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects. | to manufacture and assess bioactivity of low fluoride/high phosphate (low f(-)/high p2o5) bioglasses (bgs). then the effects of bg-conditioned medium on osteoblast-like cell behavior and bg particles on bactericidal activity were investigated. | 2016 | 27461261 |
| oxygen high level laser therapy is efficient in treatment of chronic periodontitis: a clinical and microbiological study using pcr analysis. | in periodontology, lasers have been suggested for the photodynamic therapy (pdt). such therapy can be defined as the inactivation of cells, microorganisms or molecules induced by light and not by heat. the aim of our study is to assess the effect of oxygen high-level laser therapy (ohllt) in removing all bacterial deposits on root or implant surface by means of mechanical instrumentation and laser irradiation. ohllt has two effects on targeted bacteria and tissues, decontamination and biostimula ... | 2016 | 27469554 |
| evaluation of the efficacy of a new oral gel containing carvacrol and thymol for home oral care in the management of chronic periodontitis using pcr analysis: a microbiological pilot study. | the use of chemical devices for domestic oral hygiene in periodontal patients has led to new treatment strategies aiming primarily at a control of infection. over the last few years, carvacrol and thymol (ct) have been subjected to many scientific and medical studies. the purpose of the present study was to assess the effect of ct on the red complex bacteria using polymerase chain reaction (pcr) for microbiological analysis. five patients with a diagnosis of chronic periodontitis in the age grou ... | 2016 | 27469559 |
| bacterial load of periodontal pathogens among italian patients with chronic periodontitis: a comparative study of three different areas. | the aim of the present study was to evaluate the mean bacterial load of some periodontal pathogenic bacteria in italian patients affected by chronic periodontitis. the sample consisted of 1,762 patients with a clinical diagnosis of chronic periodontitis based on the criteria of the american academy of periodontology sampled in the period 2013-2015; 1,323 patients were from northern italy, 317 from central italy and 122 from southern italy. samples for microbiological analysis were collected from ... | 2016 | 27469562 |
| an assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens. | numerous studies have proposed that smooth metal surfaces reduce initial bacterial attachment in the establishment of an early biofilm formation. however, these studies have largely examined single bacterial species, which are not always relevant as pathogens identified as initiators of inflammatory peri-implantitis. this study investigated the adherence of four periodontally-relevant bacterial species to implant and abutment surfaces in current clinical use. | 2016 | 27472955 |
| nucleases from prevotella intermedia can degrade neutrophil extracellular traps. | periodontitis is an inflammatory disease caused by periodontal bacteria in subgingival plaque. these bacteria are able to colonize the periodontal region by evading the host immune response. neutrophils, the host's first line of defense against infection, use various strategies to kill invading pathogens, including neutrophil extracellular traps (nets). these are extracellular net-like fibers comprising dna and antimicrobial components such as histones, ll-37, defensins, myeloperoxidase, and neu ... | 2016 | 27476978 |
| oral pathogens change proliferation properties of oral tumor cells by affecting gene expression of human defensins. | the impact of oral pathogens onto the generation and variability of oral tumors has only recently been investigated. to get further insights, oral cancer cells were treated with pathogens and additionally, as a result of this bacterial cellular infection, with human defensins, which are as anti-microbial peptide members of the innate immune system. after cell stimulation, proliferation behavior, expression analysis of oncogenic relevant defensin genes, and effects on egfr signaling were investig ... | 2016 | 27481514 |
| detection of selected periodontal bacteria in preschool children affected by early childhood caries. | the aim of this study was to compare the detection frequency of periodontal bacteria in dental plaque in children with early childhood caries (ecc) with and without gingival inflammation. a convenience sample of 25 preschool children (mean age 3.61 years, sd 1.42) was recruited. dental plaque was taken from periodontal areas with and without visible signs of inflammation and processed using the stomagene® (protean s.r.o. czech republic) and parocheck® 20 (greiner bio-one gmbh, germany) detection ... | 2016 | 27485551 |
| transcriptome analysis of b cell immune functions in periodontitis: mucosal tissue responses to the oral microbiome in aging. | evidence has shown activation of t and b cells in gingival tissues in experimental models and in humans diagnosed with periodontitis. the results of this adaptive immune response are noted both locally and systemically with antigenic specificity for an array of oral bacteria, including periodontopathic species, e.g., porphyromonas gingivalis and aggregatibacter actinomycetemcomitans. it has been recognized through epidemiological studies and clinical observations that the prevalence of periodont ... | 2016 | 27486459 |
| human serum-specific activation of alternative sigma factors, the stress responders in aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans, a known pathogen causing periodontal disease and infective endocarditis, is a survivor in the periodontal pocket and blood stream; both environments contain serum as a nutrient source. to screen for unknown virulence factors associated with this microorganism, a. actinomycetemcomitans was grown in serum-based media to simulate its in vivo environment. different strains of a. actinomycetemcomitans showed distinct growth phenotypes only in the presence of hum ... | 2016 | 27490177 |
| systemic aggregatibacter actinomycetemcomitans leukotoxin-neutralizing antibodies in periodontitis. | leukotoxin (ltx) expressed by aggregatibacter actinomycetemcomitans is a powerful exotoxin, which can cause imbalance in host response. immunoreactivity to ltx is a marker for presence of leukotoxic a. actinomycetemcomitans, a presence that may modify the disease pattern of colonized individuals. the aim of the present study is to examine presence of systemic immunoreactivity to a. actionmycetemcomitans ltx with respect to clinical and inflammatory findings in individuals with or without periodo ... | 2017 | 27523521 |
| inhibition of p2x receptors protects human monocytes against damage by leukotoxin from aggregatibacter actinomycetemcomitans and α-hemolysin from escherichia coli. | α-hemolysin (hlya) from escherichia coli and leukotoxin a (ltxa) from aggregatibacter actinomycetemcomitans are important virulence factors in ascending urinary tract infections and aggressive periodontitis, respectively. the extracellular signaling molecule atp is released immediately after insertion of the toxins into plasma membranes and, via p2x receptors, is essential for the erythrocyte damage inflicted by these toxins. moreover, atp signaling is required for the ensuing recognition and ph ... | 2016 | 27528275 |
| oxygen as a virulence determinant in polymicrobial infections. | infections caused by multiple organisms, or polymicrobial infections, are likely more common than is broadly appreciated. interaction among microbial communities (and with their host) can change the infection landscape by subverting immunity, providing nutrients and inhibiting competing microbes. stacy et al. (a. stacy, d. fleming, r. j. lamont, k. p. rumbaugh, and m. whiteley, mbio 7:e00782-16, 2016, http://dx.doi.org/10.1128/mbio.00782-16) described a novel mechanism that results in synergisti ... | 2016 | 27531913 |
| melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection. | alveolar bone loss is a result of an aggressive form of periodontal disease (pd) associated with aggregatibacter actinomycetemcomitans (aa) infection. pd is often observed with other systemic inflammatory conditions, including arthritis. melanocortin peptides activate specific receptors to exert antiarthritic properties, avoiding excessing inflammation and modulating macrophage function. recent work has indicated that melanocortin can control osteoclast development and function, but whether such ... | 2016 | 27535487 |
| longitudinal study on clinical and microbial analysis of periodontal status in pregnancy. | this study was aimed to provide a longitudinal overview of the subgingival bacterial microbiome using fluorescence in situ hybridization (fish) technique, in women in the second trimester of pregnancy (between 14 and 24 weeks), and 48 h and 8 weeks postpartum. of 31 women evaluated during pregnancy, 24 returned for the 48-h and 18 for their 8-week exams postpartum. probing depth (pd), bleeding on probing, clinical attachment level, and presence of calculus were recorded. subgingival plaque sampl ... | 2016 | 27556678 |
| prevalence of periodontopathogens and candida spp. in smokers after nonsurgical periodontal therapy - a pilot study. | this pilot study aimed to evaluate the influence of smoking on clinical and microbiological parameters after nonsurgical periodontal therapy. forty-eight subjects were grouped into smokers (sm, n = 24) and nonsmokers (ns, n = 24) and paired according to gender, age, ethnicity, and periodontal status. both groups received oral hygiene education and scaling and root planing. clinical evaluation was performed using plaque index (pi), bleeding on probing (bop), pocket probing depth (ppd), gingival r ... | 2016 | 27556680 |
| a journey of cytolethal distending toxins through cell membranes. | the multifunctional role of lipids as structural components of membranes, signaling molecules, and metabolic substrates makes them an ideal partner for pathogens to hijack host cell processes for their own survival. the properties and composition of unique membrane micro-domains such as membrane rafts make these regions a natural target for pathogens as it affords them an opportunity to hijack cell signaling and intracellular trafficking pathways. cytolethal distending toxins (cdts), members of ... | 2016 | 27559534 |
| d-galactose as an autoinducer 2 inhibitor to control the biofilm formation of periodontopathogens. | autoinducer 2 (ai-2) is a quorum sensing molecule to which bacteria respond to regulate various phenotypes, including virulence and biofilm formation. ai-2 plays an important role in the formation of a subgingival biofilm composed mostly of gram-negative anaerobes, by which periodontitis is initiated. the aim of this study was to evaluate d-galactose as an inhibitor of ai-2 activity and thus of the biofilm formation of periodontopathogens. in a search for an ai-2 receptor of fusobacterium nuclea ... | 2016 | 27572513 |
| novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating. | the purpose of this investigation was to determine the ability of tetracycline-containing fibers to inhibit biofilm formation of peri-implantitis-associated pathogens [i.e., porphyromonas gingivalis (pg), fusobacterium nucleatum (fn), prevotella intermedia (pi), and aggregatibacter actinomycetemcomitans (aa)]. tetracycline hydrochloride (tch) was added to a poly(dl-lactide) [pla], poly(ε-caprolactone) [pcl], and gelatin [gel] polymer blend solution at distinct concentrations to obtain the follow ... | 2016 | 27585669 |
| adhesion of periodontal pathogens to self-ligating orthodontic brackets: an in-vivo prospective study. | our aims were to analyze adhesion of periodontopathogens to self-ligating brackets (clarity-sl [csl], clippy-c [cc] and damon q [dq]) and to identify the relationships between bacterial adhesion and oral hygiene indexes. | 2016 | 27585775 |
| detection of porphyromonas gingivalis and aggregatibacter actinomycetemcomitans after systemic administration of amoxicillin plus metronidazole as an adjunct to non-surgical periodontal therapy: a systematic review and meta-analysis. | to evaluate the variations in the detection of porphyromonas gingivalis and/or aggregatibacter actinomycetemcomitans before and after systemic administration of amoxicillin plus metronidazole in association with non-surgical periodontal therapy (nspt). | 2016 | 27594851 |
| micrornas regulate cytokine responses in gingival epithelial cells. | micrornas (mirnas) have been established as key regulators of various biological processes with possible involvement in the pathobiology of periodontal disease. expanding our earlier observations of substantial differential expression of specific mirnas between clinically healthy and periodontitis-affected gingival tissues, we used mirna inhibitors (sponges) in loss-of-function experiments to investigate the involvement of specific mirnas in the response of pocket epithelium-derived, telomerase- ... | 2016 | 27600506 |
| effect of helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation. | helicobacter pylori (h. pylori), a pathogen inducing peptic disease, is recently found to be binding to the progress of periodontitis. most previous studies are case-controlled, and they investigate the risk of h. pylori infection in disease the development of while few studies evaluate the correlation between h. pylori and periodontal pathogens. therefore, we investigated the correlation between h. pylori infection with periodontal parameters, periodontal pathogens and inflammation. the results ... | 2016 | 27602578 |
| role of nod2 and rip2 in host-microbe interactions with gram-negative bacteria: insights from the periodontal disease model. | nod2 is a member of the nlr family of proteins that participate in the activation of the innate immune response. rip2 is a downstream kinase activated by both nod1 and nod2. there is scarcity of information regarding the relevance of nod2 in periodontitis, a chronic inflammatory condition characterized by inflammatory bone resorption. we used nod2-ko and rip2-ko mice in a model of microbial-induced periodontitis. heat-killed aggregatibacter actinomycetemcomitans was injected in the gingival tiss ... | 2016 | 27605548 |
| herpesviral-bacterial co-infection in mandibular third molar pericoronitis. | the aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. | 2016 | 27620215 |
| virulence factors associated with aggregatibacter actinomycetemcomitans and their role in promoting periodontal diseases. | 2017 | 27623711 | |
| mannose-binding lectin gene polymorphism in relation to periodontal infection. | mannose-binding lectin (mbl) plays an important role in innate immunity. mbl deficiency is usually caused by mutations in exon 1 of the mbl structural gene (mbl2). our aim was to investigate mbl2 polymorphisms and their relation to salivary levels of periodontal inflammatory/tissue destruction markers and two major periodontitis-associated bacteria. | 2016 | 27624657 |
| the distribution of porphyromonas gingivalis, tannerella forsythia, treponema denticola and aggregatibacter actinomycetemcomitans in patients with alcoholic disease: a pilot study. | both drinking and periodontal disease are serious health and social problems. findings on the effect of alcohol consumption on periodontal disease are inconclusive. | 2016 | 27627556 |
| evaluation of moxifloxacin-hydroxyapatite composite graft in the regeneration of intrabony defects: a clinical, radiographic, and microbiological study. | the formation of new connective periodontal attachment is contingent upon the elimination or marked reduction of pathogens at the treated periodontal site. an anti-microbial agent, i.e. moxifloxacin has been incorporated into the bone graft to control infection and facilitate healing during and after periodontal therapy. | 2016 | 27630501 |
| a double-blind randomized trial comparing implants with laser-microtextured and machined collar surfaces: microbiologic and clinical results. | the purpose of this study was to compare the clinical outcome of and determine the differences in periodonto-pathogenic microbiota around two types of implant collar surfaces: laser-microtextured (test) vs machined (control). | 2017 | 27632268 |
| physicochemical fabrication of antibacterial calcium phosphate submicrospheres with dispersed silver nanoparticles via coprecipitation and photoreduction under laser irradiation. | we achieved rapid, surfactant-free, and one-pot fabrication of antibacterial calcium phosphate (cap) submicrospheres containing silver nanoparticles by combining physical laser and chemical coprecipitation processes. in this physicochemical process, weak pulsed laser irradiation (20min) was performed on a labile cap reaction mixture supplemented with silver ions as a light-absorbing agent. the silver content in the submicrospheres was controlled for a wide range (ag/p elemental ratio varied from ... | 2016 | 27640919 |
| innate immune response of human embryonic stem cell-derived fibroblasts and mesenchymal stem cells to periodontopathogens. | periodontitis involves complex interplay of bacteria and host immune response resulting in destruction of supporting tissues of the tooth. toll-like receptors (tlrs) play a role in recognizing microbial pathogens and eliciting an innate immune response. recently, the potential application of multipotent stem cells and pluripotent stem cells including human embryonic stem cells (hescs) in periodontal regenerative therapy has been proposed. however, little is known about the impact of periodontopa ... | 2016 | 27642305 |
| antimicrobial effect of chlorhexidine on aggregatibacter actinomycetemcomitans biofilms associated with peri-implantitis. | background. this study aimed to assessthe antimicrobial effect of chlorhexidine (chx) on aggregatibacter actinomycetemcomitans biofilms isolated from subgingival plaque of peri-implantitis lesions. methods. thirteen patients requiring peri-implantitis treatment were consecutively selected and their subgingival biofilm was collected by inserting fine sterile paper points into peri-implant pockets for 15 seconds. a. actinomycetemcomitans was isolated from the subgingival biofilm and cultured. in t ... | 2016 | 27651884 |
| in vitro complement activation, adherence to red blood cells and induction of mononuclear cell cytokine production by four strains of aggregatibacter actinomycetemcomitans with different fimbriation and expression of leukotoxin. | the periodontal pathogen aggregatibacter actinomycetemcomitans has been proposed as pro-atherogenic, and complement-mediated adherence to red blood cells (rbcs) may facilitate its systemic spread. we investigated the ability of four strains of a. actinomycetemcomitans with differential expression of leukotoxin a (ltxa) and fimbriae to activate complement, adhere to rbcs and elicit cytokine responses by mononuclear cells (mncs). | 2016 | 27663487 |
| novel strategy to detect and locate periodontal pathogens: the pna-fish technique. | we aim to develop peptic nucleic acid (pna) probes for the identification and localization of aggregatibacter actinomycetemcomintans and porphyromonas gingivalis in sub-gingival plaque and gingival biopsies by fluorescence in situ hybridization (fish). | 2016 | 27664736 |
| microbial characteristics of peri-implantitis: a case-control study. | the aim of this case-control study is to compare oral microbiologic characteristics of patients with healthy peri-implant conditions and patients with peri-implantitis and to explore the influence of various patient- and implant-related factors on microbiologic characteristics. | 2017 | 27666672 |
| novel bioactive nanocomposite for class-v restorations to inhibit periodontitis-related pathogens. | the occurrence of tooth root caries is increasing as the world population ages and tooth retention in seniors increases. class v restorations with subgingival margins are difficult to clean and often lead to periodontitis. the objectives of this study were to develop a class v composite containing dimethylaminohexadecyl methacrylate (dmahdm) and nanoparticles of amorphous calcium phosphate (nacp), and investigate mechanical properties and the inhibition of six species of periodontitis-related bi ... | 2016 | 27671471 |
| evaluation of the antibacterial potential of liquid and vapor phase phenolic essential oil compounds against oral microorganisms. | the aim of the present study was to determine the antibacterial activities of the phenolic essential oil (eo) compounds hinokitiol, carvacrol, thymol, and menthol against oral pathogens. aggregatibacter actinomycetemcomitans, streptococcus mutans, methicillin-resistant staphylococcus aureus (mrsa), and escherichia. coli were used in this study. the minimum inhibitory concentrations (mics), minimum bactericidal concentrations (mbcs), bacterial growth curves, temperature and ph stabilities, and sy ... | 2017 | 27681039 |
| outer membrane protein 100 of aggregatibacter actinomycetemcomitans act as a biopharmaceutical target for photodynamic therapy: an in silico analysis. | periodontitis is a polymicrobial, chronic, and degenerative disease that can lead to destruction of the teeth-supporting tissues and eventually to loss of teeth. aggregatibacter actinomycetemcomitans is predominantly associated with periodontal diseases. outer membrane protein (omp) 100 is a more important virulence factor of a. actinomycetemcomitans due to the effect of adhesion and invasion into human gingival epithelial cells. attachment of a. actinomycetemcomitans inhibition is significant i ... | 2016 | 27697516 |
| effect of bioactive dental adhesive on periodontal and endodontic pathogens. | the objectives of this study were to: (1) develop a new bioactive dental bonding agent with nanoparticles of amorphous calcium phosphate and dimethylaminohexadecyl methacrylate for tooth root caries restorations and endodontic applications, and (2) investigate biofilm inhibition by the bioactive bonding agent against eight species of periodontal and endodontic pathogens for the first time. bonding agent was formulated with 5 % of dimethylaminohexadecyl methacrylate. nanoparticles of amorphous ca ... | 2016 | 27699574 |
| structural and functional analysis of de-n-acetylase pgab from periodontopathogen aggregatibacter actinomycetemcomitans. | the oral pathogen aggregatibacter actinomycetemcomitans uses pga gene locus for the production of an exopolysaccharide made up of a linear homopolymer of β-1,6-n-acetyl-d-glucosamine (pga). an enzyme encoded by the pgab of the pga operon in a. actinomycetemcomitans is a de-n-acetylase, which is used to alter the pga. the full length enzyme (aapgab) and the n-terminal catalytic domain (residues 25-290, aapgabn) from a. actinomycetemcomitans were cloned, expressed and purified. the enzymatic activ ... | 2016 | 27706922 |
| does obesity influence the subgingival microbiota composition in periodontal health and disease? | to evaluate whether obesity affects the subgingival microbial composition of patients with periodontal health or chronic periodontitis (cp). | 2016 | 27717180 |
| irradiation effects of low temperature multi gas plasma jet on oral bacteria. | the purpose of this study is to evaluate the sterilization effects of a newly developed low temperature multi gas plasma jet on oral pathogenic microorganisms (streptococcus mutans [s. mutans], lactobacillus fermentum [l. fermentum], aggregatibacter actinomycetemcomitans [a. actinomycetemcomitans]). plasma gas which generated from o2, n2, ar and 50% (o2+n2) was irradiated to the microbes. effect of o2 plasma irradiation on s. mutans under scanning electron microscopy (sem) was also observed. o2 ... | 2016 | 27725521 |
| association between infectious burden, socioeconomic status, and ischemic stroke. | infectious diseases contribute to stroke risk, and are associated with socioeconomic status (ses). we tested the hypotheses that the aggregate burden of infections increases the risk of ischemic stroke (is) and partly explains the association between low ses and ischemic stroke. | 2016 | 27728851 |
| bacterial heat shock protein groel (hsp64) exerts immunoregulatory effects on t cells by utilizing apoptosis. | aggregatibacter actinomycetemcomitans (aa) expresses a 64-kda groel protein belonging to the heat shock family of proteins. this protein has been shown to influence human host cells, but the apoptotic capacity of the groel protein regarding t cells is not yet known. the purpose of this study was to investigate the ability of a. actinomycetemcomitans groel (aagroel) protein to induce human peripheral blood t-cell apoptosis. endogenous, purified aagroel protein was used as an antigen. in aagroel-t ... | 2016 | 27736933 |
| rosuvastatin inhibits interleukin (il)-8 and il-6 production in human coronary artery endothelial cells stimulated with aggregatibacter actinomycetemcomitans serotype b. | rosuvastatin exhibits anti-inflammatory effects and reduces periodontal diseases and atherosclerosis; however, its role in regulating periodontopathogen-induced endothelial proinflammatory responses remains unclear. the purpose of this study is to determine whether rosuvastatin can reduce the proinflammatory response induced by aggregatibacter actinomycetemcomitans (aa) in human coronary artery endothelial cells (hcaecs). | 2017 | 27739345 |
| human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. | a history of periodontal disease and the presence of circulating antibodies to selected oral pathogens have been associated with increased risk of pancreatic cancer; however, direct relationships of oral microbes with pancreatic cancer have not been evaluated in prospective studies. we examine the relationship of oral microbiota with subsequent risk of pancreatic cancer in a large nested case-control study. | 2016 | 27742762 |
| mobilization of tlr4 into lipid rafts by aggregatibacter actinomycetemcomitans in gingival epithelial cells. | an investigation of the mechanisms underlying the production of inflammatory cytokines through the stimulation of microorganisms on gingival epithelial cells may provide insights into the pathogenesis of the initiation of periodontitis. lipid rafts, microdomains in the cell membrane, include a large number of receptors, and are centrally involved in signal transduction. we herein examined the involvement of lipid rafts in the expression of interleukin (il-6) and il-8 in gingival epithelial cells ... | 2016 | 27744428 |
| comparison of two different sampling methods for subgingival plaque: subgingival paper points or mouthrinse sample? | the collection of subgingival plaque samples with paper points is time-consuming and accident-sensitive. however, the collection of saliva is simple and contains pathogens of all intraoral surfaces. the aim of this study is to investigate whether a sampling strategy with mouthrinse (mouthrinse sample [msp]; test) leads to results comparable with standard sampling method (multiple site test from the deepest pocket of each quadrant [mt4]; control). | 2017 | 27786617 |
| [a case of mediastinum actinomycosis by aggregatibacter actinomycetemcomitans]. | the actinomycosis is a suppurative infection due to an anaerobic and microaerophillic bacteria called actinomyces. only few case reports are described for the mediastinal locations of this rare entity. we report a new case of inflammatory pseudotumor in the mediastinum due to aggregatibacte actinomycetemcomitans revealed by hemoptysis. the mediastinoscopy procedure with biopsy was needed to confirm the definitive bacteriological diagnosis by a positive culture. during the postoperative course, a ... | 2016 | 27789164 |
| changes in salivary periodontal pathogens after orthodontic treatment: an in vivo prospective study. | to analyze the initial changes in salivary levels of periodontal pathogens after orthodontic treatment with fixed appliances. | 2016 | 27792427 |
| periodontal and microbiological profile of intensive care unit inpatients. | the bidirectional relationship between the periodontal diseases and systemic diseases was attributed to the focal infection concept. the aims of this study were to assess the periodontal and microbiological profile of intensive care unit (icu) inpatients submitted to orotracheal intubation, and classify them regarding gender, age group, ethnic, hospitalization reason and period, nosocomial infection occurrence, and death. | 2016 | 27794150 |
| mitogen-activated protein kinase 2 signaling shapes macrophage plasticity in aggregatibacter actinomycetemcomitans-induced bone loss. | aggregatibacter actinomycetemcomitans is associated with aggressive periodontal disease, which is characterized by inflammation-driven alveolar bone loss. a. actinomycetemcomitans activates the p38 mitogen-activated protein kinase (mapk) and mapk-activated protein kinase 2 (mk2) stress pathways in macrophages that are involved in host responses. during the inflammatory process in periodontal disease, chemokines are upregulated to promote recruitment of inflammatory cells. the objective of this s ... | 2017 | 27795356 |
| localization and expression pattern of amelotin, odontogenic ameloblast-associated protein and follicular dendritic cell-secreted protein in the junctional epithelium of inflamed gingiva. | the purpose of this study is to elucidate the localization of amelotin (amtn), odontogenic ameloblast-associated protein (odam) and follicular dendritic cell-secreted protein (fdc-sp) at the junctional epithelium (je) in porphyromonas gingivalis and aggregatibacter actinomycetemcomitans infected mice and inflamed and non-inflamed human gingiva. we performed immunostaining to determine the localization and expression pattern of amtn, odam and fdc-sp. amtn, odam and fdc-sp in a. actinomycetemcomit ... | 2016 | 27807653 |
| assessment of photodynamic inactivation against periodontal bacteria mediated by a chitosan hydrogel in a 3d gingival model. | chitosan hydrogels containing hydroxypropyl methylcellulose (hpmc) and toluidine blue o were prepared and assessed for their mucoadhesive property and antimicrobial efficacy of photodynamic inactivation (pdi). increased hpmc content in the hydrogels resulted in increased mucoadhesiveness. furthermore, we developed a simple in vitro 3d gingival model resembling the oral periodontal pocket to culture the biofilms of staphylococcus aureus (s. aureus), aggregatibacter actinomycetemcomitans (a. actin ... | 2016 | 27809278 |
| microbiological and clinical assessment of the abutment and non-abutment teeth of partial removable denture wearers. | the aim of this study was assessing the changes in both clinical and microbiological parameters of healthy individuals after rehabilitation with removable partial denture (rpd). | 2017 | 27825678 |
| regulation of matrix metalloproteinase secretion by green tea catechins in a three-dimensional co-culture model of macrophages and gingival fibroblasts. | elevated levels of matrix metalloproteinases (mmps) have been associated with the active phases of tissue and bone destruction in periodontitis, an inflammatory disease characterized by a significant breakdown of tooth support. in the present study, we used a three-dimensional (3d) co-culture model of macrophages and gingival fibroblasts to investigate the ability of a green tea extract and its major constituent epigallocatechin-3-gallate (egcg) to regulate the secretion of mmp-3, -8, and -9. | 2017 | 27825679 |
| influence of culture conditions on porphyrin production in aggregatibacter actinomycetemcomitans and porphyromonas gingivalis. | increasing antibiotic resistance among pathogens has raised the demands for new treatment methods such as antimicrobial photodynamic therapy (apdt) and phototherapy (pt). experiments for investigating the effects of these methods are often performed in vitro, but the procedures for cultivation of microbes vary between different studies. the aim of this study has been to elucidate how the profile of endogenously produced porphyrins differs by changing the variables of bacteria culturing condition ... | 2017 | 27825899 |
| periodontitis and myocardial hypertrophy. | there is a deep relationship between cardiovascular disease and periodontitis. it has been reported that myocardial hypertrophy may be affected by periodontitis in clinical settings. although these clinical observations had some study limitations, they strongly suggest a direct association between severity of periodontitis and left ventricular hypertrophy. however, the detailed mechanisms between myocardial hypertrophy and periodontitis have not yet been elucidated. recently, we demonstrated tha ... | 2017 | 27829660 |
| thermoreversible gel for intrapocket delivery of green tea catechin as a local drug delivery system: an original research. | the periodontal therapies along with systemic antibiotic therapy aim at eliminating the subgingival microbiota to arrest the progression of periodontal diseases. the complete elimination is often difficult, and thus the probability of repopulation after periodontal therapy is also high. the objectives of the study are to develop in situ thermoreversible gelling system of green tea catechins suitable for periodontal pocket administration, which would act as an adjunct to mechanical periodontal th ... | 2017 | 27833893 |
| effects of aggregatibacter actinomycetemcomitans leukotoxin on neutrophil migration and extracellular trap formation. | aggressive periodontitis is associated with the presence of aggregatibacter actinomycetemcomitans, a leukotoxin (ltx)-producing periodontal pathogen. ltx has the ability to lyse white blood cells including neutrophils. | 2016 | 27834173 |
| complete genome sequence of aggregatibacter actinomycetemcomitans strain idh781. | we report here the complete genomic sequence and methylome of aggregatibacter actinomycetemcomitans strain idh781. this rough strain is used extensively as a model organism to characterize localized aggressive periodontitis pathogenesis, the basic biology and oral cavity colonization of a. actinomycetemcomitans, and its interactions with other members of the oral microbiome. | 2016 | 27834722 |
| nanofibers containing tetracycline/β-cyclodextrin: physico-chemical characterization and antimicrobial evaluation. | this study aimed to compare two nanofiber drug delivery systems that were prepared with an electrospun process and have the potential to serve as adjuvants for the treatment of periodontal disease. the first system was composed of polycaprolactone loaded with tetracycline (tcn) and the second was composed of polycaprolactone loaded with tetracycline/β-cyclodextrin (tcn:bcd). an antimicrobial diffusion test was performed for each of these sets of nanofibers with the microorganisms, aggregatibacte ... | 2017 | 27842841 |
| nadph oxidase contributes to resistance against aggregatibacter actinomycetemcomitans-induced periodontitis in mice. | aggregatibacter actinomycetemcomitans is a gram-negative commensal bacterium of the oral cavity which has been associated with the pathogenesis of periodontitis with severe alveolar bone destruction. the role of host factors such as reactive oxygen and nitrogen intermediates in periodontal a. actinomycetemcomitans infection and progression to periodontitis is still ill-defined. therefore, this study aimed to analyze the role of nadph oxidase and inducible nitric oxide synthase (inos) in a murine ... | 2017 | 27849181 |
| detection and quantification of aggregatibacter actinomycetemcomitans, porphyromonas gingivalis and streptococcus oralis in blood samples with different microbiological identification methods: an in vitro study. | culture-based methods (culture broth bottles or lysis methods) have been the standard for detecting bacteremia. more recently, quantitative polymerase chain reaction (qpcr) was proposed as a more sensitive and specific test although none of them has been validated for the identification of periodontal pathogens (fastidious growing bacteria) in blood samples. | 2017 | 27875793 |
| effects of ozone nano-bubble water on periodontopathic bacteria and oral cells - in vitro studies. | the aims of the present study were to evaluate the bactericidal activity of a new antiseptic agent, ozone nano-bubble water (nbw3), against periodontopathogenic bacteria and to assess the cytotoxicity of nbw3 against human oral cells. the bactericidal activities of nbw3 against representative periodontopathogenic bacteria, porphyromonas gingivalis (p. gingivalis) and aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) were evaluated using in vitro time-kill assays. the cytotoxicity ... | 2014 | 27877715 |
| prevalence of periodontal pathogens as predictor of the evolution of periodontal status. | the aim of this study was to determine the relationship between the prevalence of porphyromonas gingivalis, its fima genotypes, aggregatibacter actinomycetemcomitans, tannerella forsythia, and treponema denticola and the evolution of periodontal health. in a longitudinal prospective study, samples of subgingival plaque were taken from 114 patients (37 with chronic periodontitis, 17 with gingivitis, and 60 periodontally healthy) in the course of a full periodontal examination. pcr was employed to ... | 2016 | 27888369 |
| high-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis. | periodontal disease (pd) is generated by microorganisms. these microbes can enter the general circulation causing a bacteraemia. the result can be adverse systemic effects, which could promote conditions such as cardiovascular disease. level a evidence supports that pd is independently associated with arterial disease. pd is a common chronic condition affecting the majority of americans 30 years of age and older. atherosclerosis remains the largest cause of death and disability. studies indicate ... | 2017 | 27899684 |
| effect of resveratrol on periodontal pathogens during experimental periodontitis in rats. | the objective of this study was to investigate the antibacterial effect of resveratrol against putative periodontal pathogens during the progression of experimental periodontitis in rats. periodontitis was induced in rats in one of the first molars chosen to receive a ligature. animals were assigned to one of two groups: daily administration of the placebo solution (control group, n = 12) or 10 mg/kg of resveratrol (resv group, n = 12). the therapies were administered systemically for 30 days, f ... | 2016 | 27901209 |