Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| lymphoid susceptibility to the aggregatibacter actinomycetemcomitans cytolethal distending toxin is dependent upon baseline levels of the signaling lipid, phosphatidylinositol-3,4,5-triphosphate. | the aggregatibacter actinomycetemcomitans cytolethal distending toxin (cdt) induces g2 arrest and apoptosis in lymphocytes and other cell types. we have shown that the active subunit, cdtb, exhibits phosphatidylinositol-3,4,5-triphosphate (pip3) phosphatase activity and depletes lymphoid cells of pip3. hence we propose that cdt toxicity results from depletion of this signaling lipid and perturbation of phosphatidylinositol-3-kinase (pi-3k)/pip3/akt signaling. we have now focused on the relations ... | 2016 | 26299277 |
| enhancing the stability and antibiofilm activity of dspb by immobilization on carboxymethyl chitosan nanoparticles. | a β-n-acetyl-glucosaminidase (dspb) from aggregatibacter actinomycetemcomitans cu1000 has been proved to inhibit and detach the biofilms formed by staphylococcus epidermidis, staphylococcus aureus and a. actinomycetemcomitans. however, the application of this enzyme is limited by its poor stability. in the present study, a β-n-acetyl-glucosaminidase encoding gene, dspb, was cloned from a. actinomycetemcomitans hk1651 and expressed in escherichia coli. the recombinant dspb was loaded on hydrogel ... | 2015 | 26302845 |
| a natural therapeutic approach for the treatment of periodontitis by mk615. | periodontitis is a chronic inflammatory disease that affects the tooth-supporting tissues. gingival fibroblasts are the most abundant cells in periodontal tissues and they participate actively in the host inflammatory response to periodontal pathogens that is known to mediate local tissue destruction in periodontitis. the japanese apricot, known as ume in japanese, has been a traditional japanese medicine for centuries and is a familiar and commonly consumed food. the health benefits of ume are ... | 2015 | 26305447 |
| the association between subgingival periodontal pathogens and systemic inflammation. | to investigate associations between periodontal disease pathogens and levels of systemic inflammation measured by c-reactive protein (crp). | 2015 | 26309048 |
| porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, and treponema denticola / prevotella intermedia co-infection are associated with severe periodontitis in a thai population. | periodontitis is a polymicrobial infection of tooth-supporting tissues. this cross-sectional study aimed to examine the associations between five target species and severe periodontitis in a thai population. using the cdc/aap case definition, individuals diagnosed with no/mild and severe periodontitis were included. quantitative analyses of aggregatibacter actinomycetemcomitans (aa), porphyromonas gingivalis (pg), tannerella forsythia (tf), treponema denticola (td), and prevotella intermedia (pi ... | 2015 | 26313005 |
| inhibitory effects of a novel cationic dodecapeptide [cl(14-25)] derived from cyanate lyase of rice on endotoxic activities of lpss from escherichia coli and periodontopathic aggregatibacter actinomycetemcomitans. | cl(14-25), a dodecapeptide of cyanate lyase from rice, is a novel cationic α-helical antimicrobial peptide. in this study, we examined inhibitory ability of cl(14-25) against endotoxic activities of lipopolysaccharides (lpss) from escherichia coli and periodontal pathogenic aggregatibacter actinomycetemcomitans. | 2016 | 26318142 |
| significant increase of oral bacteria in the early pregnancy period in japanese women. | oral microflora during pregnancy is critical to oral health care in the mother and her child. we examined the changes in the oral microbiota between pregnancy and nonpregnancy periods. | 2017 | 26345599 |
| inhibition of ltxa toxicity by blocking cholesterol binding with peptides. | the leukotoxin (ltxa) produced by aggregatibacter actinomycetemcomitans kills host immune cells, allowing the bacterium to establish an ecological niche in the upper aerodigestive tract of its human host. the interaction of ltxa with human immune cells is both complex and multifaceted, involving membrane lipids as well as cell-surface proteins. in the initial encounter with the host cell, ltxa associates with lymphocyte function-associated antigen-1, a cell surface adhesion glycoprotein. however ... | 2015 | 26352738 |
| subgingivally applied minocycline microgranules in subjects with chronic periodontitis: a randomized clinical and microbiological trial. | the aim of this study was to evaluate clinical and microbiological effects of subgingival minocycline microgranules when used as an adjunct to scaling and root planing in subjects with chronic periodontitis. twenty-six non-smoker volunteers participated in the study. four opposite sites, clinically standardized, with bleeding on probing (bop) and pocket depth (pd) ≥ 6 mm were selected. baseline bop, pd and clinical attachment level (cal) were measured and microbiological samples were collected f ... | 2015 | 26355881 |
| aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in lfa-1 expressing immune cells. | studies have suggested that aggregatibacter actinomycetemcomitans leukotoxin (ltxa) kills human lymphocyte function-associated antigen 1 (lfa-1; cd11a/cd18)-bearing immune cells through a lysosomal-mediated mechanism. lysosomes are membrane-bound cellular organelles that contain an array of acid hydrolases that are capable of breaking down biomolecules. the lysosomal membrane bilayer confines the ph-sensitive enzymes within an optimal acidic (ph 4.8) environment thereby protecting the slightly b ... | 2016 | 26361372 |
| association of periodontitis with persistent, pro-atherogenic antibody responses. | to study antibody responses associated with molecular mimicry in periodontitis. | 2015 | 26362847 |
| evaluation of the antibacterial effect of silver nanoparticles on guided tissue regeneration membrane colonization--an in vitro study. | the aim of this in vitro study was to investigate the colonization and penetration of specific bacteria on nanosilver-impregnated gtr (guided tissue regeneration) membranes. | 2015 | 26373223 |
| proteomics of aggregatibacter actinomycetemcomitans outer membrane vesicles. | aggregatibacter actinomycetemcomitans is an oral and systemic pathogen associated with aggressive forms of periodontitis and with endocarditis. outer membrane vesicles (omvs) released by this species have been demonstrated to deliver effector proteins such as cytolethal distending toxin (cdt) and leukotoxin (ltxa) into human host cells and to act as triggers of innate immunity upon carriage of nod1- and nod2-active pathogen-associated molecular patterns (pamps). to improve our understanding of t ... | 2015 | 26381655 |
| periodontal clinical and microbiological characteristics in healthy versus generalized aggressive periodontitis families. | generalized aggressive periodontitis (gap) is a severe and multifactorial disease in which a familial aggregation and a specific microbiological profile have been suggested. thus, this case-control study evaluated the clinical and subgingival microbial profile of gap subjects and their families compared to healthy families. | 2015 | 26392039 |
| evolutionary divergence of aggregatibacter actinomycetemcomitans. | gram-negative facultative aggregatibacter actinomycetemcomitans is an oral pathogen associated with periodontitis. the genetic heterogeneity among a. actinomycetemcomitans strains has been long recognized. this study provides a comprehensive genomic analysis of a. actinomycetemcomitans and the closely related nonpathogenic aggregatibacter aphrophilus. whole genome sequencing by illumina miseq platform was performed for 31 a. actinomycetemcomitans and 2 a. aphrophilus strains. sequence similarity ... | 2016 | 26420795 |
| protein biomarkers and microbial profiles in peri-implantitis. | the aim of the present investigation was to determine the profile of peri-implant crevicular fluid (picf) biomarkers combined with microbial profiles from implants with healthy peri-implant tissues and peri-implantitis to assess real-time disease activity. | 2016 | 26424287 |
| qsebc, a two-component bacterial adrenergic receptor and global regulator of virulence in enterobacteriaceae and pasteurellaceae. | the qsebc two-component system (tcs) is associated with quorum sensing and functions as a global regulator of virulence. based on sequence similarity within the sensor domain and conservation of an acidic motif essential for signal recognition, qsebc is primarily distributed in the enterobacteriaceae and pasteurellaceae. in escherichia coli, qsec responds to autoinducer-3 and/or epinephrine/norepinephrine. binding of epinephrine/norepinephrine is inhibited by adrenergic antagonists; hence qsec f ... | 2015 | 26426681 |
| revelation of viral - bacterial interrelationship in aggressive periodontitis via polymerase chain reaction: a microbiological study. | periodontal disease is one of the most common and complex disease affecting mankind. being multifactorial in etiology it encompasses a variety of infectious entities with various unique microbial constellations and immune responses. a bacteriologic cause alone seems insufficient in explaining several clinical features of the periodontal disease. recent studies suggest that periodontal herpes viruses comprise an important source of triggering periodontal tissue destruction. the following study ai ... | 2015 | 26435627 |
| antibacterial activity of curcumin against periodontopathic bacteria. | curcumin is a polyphenol extracted from root of turmeric and known to possess multifunctional properties, including antibacterial activity. although previous studies have investigated the effects of curcumin on microorganisms, available knowledge on the effects of curcumin on periodontopathic bacteria is still limited. in this study, the antibacterial effect of curcumin on periodontopathic bacteria is investigated, particularly porphyromonas gingivalis. | 2016 | 26447754 |
| in vitro antimicrobial and antiproliferative activity of amphipterygium adstringens. | amphipterygium adstringens is a plant widely used in mexican traditional medicine for its known anti-inflammatory and antiulcer properties. in this work, we evaluated the in vitro antimicrobial and antiproliferative activities of the methanolic extract of a. adstringens against oral pathogens such as streptococcus mutans, porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, candida albicans, and candida dubliniensis, using microdilution (mic) and agar diffusion methods (mbc), and the ... | 2015 | 26451151 |
| comparison of riboflavin and toluidine blue o as photosensitizers for photoactivated disinfection on endodontic and periodontal pathogens in vitro. | photoactivated disinfection has a strong local antimicrobial effect. in the field of dentistry it is an emerging adjunct to mechanical debridement during endodontic and periodontal treatment. in the present study, we investigate the effect of photoactivated disinfection using riboflavin as a photosensitizer and blue led light for activation, and compare it to photoactivated disinfection with the widely used combination of toluidine blue o and red light. riboflavin is highly biocompatible and can ... | 2015 | 26469348 |
| oral microbiota, periodontal status, and osteoporosis in postmenopausal females. | alterations in hormone levels during menopause decrease bone density and may worsen oral health, favoring the growth of periodontal pathogens, whose detection could improve the diagnosis of periodontitis. the aim of this study is to detect and quantify the main periodontal pathogens in the oral microbiota of postmenopausal females and to explore the relationship between clinical and periodontal parameters. | 2016 | 26469811 |
| secreted adenosine triphosphate from aggregatibacter actinomycetemcomitans triggers chemokine response. | extracellular atp (eatp) is an important intercellular signaling molecule secreted by activated immune cells or released by damaged cells. in mammalian cells, a rapid increase of atp concentration in the extracellular space sends a danger signal, which alerts the immune system of an impending danger, resulting in recruitment and priming of phagocytes. recent studies show that bacteria also release atp into the extracellular milieu, suggesting a potential role for eatp in host-microbe interaction ... | 2016 | 26470857 |
| interleukin-1 receptor antagonist has a novel function in the regulation of matrix metalloproteinase-13 expression. | interleukin-1 receptor antagonist (il-1ra) is an il-1 family member, which binds to il-1 receptors but does not induce any intracellular signaling. we addressed whether il-1ra has a novel function in regulation of the extracellular matrix or adhesion molecules. polymerase chain reaction array analysis demonstrated a ~5-fold increase in matrix metalloproteinase 13 (mmp-13) mrna expression of il-1ra sirna-transfected ca9-22 human oral squamous epithelial carcinoma cells compared with the control. ... | 2015 | 26474296 |
| [analysis of serum igg titers to aggregatibacter actinomycetemcomitans serotype c in aggressive periodontitis patients]. | to analyze the serum igg titers to aggregatibacter actinomycetemcomitans(aa) and associated factors in patients with aggressive periodontitis (agp). | 2015 | 26474623 |
| aggregatibacter actinomycetemcomitans serotypes and dgge subtypes in thai adults with chronic periodontitis. | to investigate the distribution of aggregatibacter actinomycetemcomitans serotypes and dgge subtypes among isolates from thai chronic periodontitis patients. | 2015 | 26475998 |
| differentiation of oral bacteria in in vitro cultures and human saliva by secondary electrospray ionization - mass spectrometry. | the detection of bacterial-specific volatile metabolites may be a valuable tool to predict infection. here we applied a real-time mass spectrometric technique to investigate differences in volatile metabolic profiles of oral bacteria that cause periodontitis. we coupled a secondary electrospray ionization (sesi) source to a commercial high-resolution mass spectrometer to interrogate the headspace from bacterial cultures and human saliva. we identified 120 potential markers characteristic for per ... | 2015 | 26477831 |
| malva sylvestris inhibits inflammatory response in oral human cells. an in vitro infection model. | the aim of this study was to investigate the in vitro anti-inflammatory activity of malva sylvestris extract (mse) and fractions in a co-culture model of cells infected by aggregatibacter actinomycetemcomitans. in addition, we evaluated the phytochemical content in the extract and fractions of m. sylvestris and demonstrated that polyphenols were the most frequent group in all samples studied. an in vitro dual-chamber model to mimic the periodontal structure was developed using a monolayer of epi ... | 2015 | 26479870 |
| quantitative pcr analysis of salivary pathogen burden in periodontitis. | our aim was to investigate the value of salivary concentrations of four major periodontal pathogens and their combination in diagnostics of periodontitis. the parogene study included 462 dentate subjects (mean age 62.9 ± 9.2 years) with coronary artery disease (cad) diagnosis who underwent an extensive clinical and radiographic oral examination. salivary levels of four major periodontal bacteria were measured by quantitative real-time pcr (qpcr). median salivary concentrations of porphyromonas g ... | 2015 | 26484315 |
| oxidative stress parameters in saliva and its association with periodontal disease and types of bacteria. | to determine the association between oxidative stress parameters with periodontal disease, bleeding, and the presence of different periodontal bacteria. | 2015 | 26494938 |
| deoxyribonucleic acid probes analyses for the detection of periodontal pathogens. | in clinical microbiology several techniques have been used to identify bacteria. recently, deoxyribonucleic acid (dna)-based techniques have been introduced to detect human microbial pathogens in periodontal diseases. deoxyribonucleic acid probes can detect bacteria at a very low level if we compared with the culture methods. these probes have shown rapid and cost-effective microbial diagnosis, good sensitivity and specificity for some periodontal pathogens in cases of severe periodontitis. | 2015 | 26522598 |
| virulence of aggregatibacter actinomycetemcomitans serotypes and dgge subtypes isolated from chronic adult periodontitis in thailand. | a high proportion of non-serotypeable isolates of aggregatibacter actinomycetemcomitans among thai periodontitis cases has been previously reported. the aim of this study was to investigate the expression of leukotoxin and toxicity, cytolethal distending toxin (cdts), and internalization and the killing effect on fibroblasts by a. actinomycetemcomitans subtypes from thai chronic periodontitis cases. a total of 96 a. actinomycetemcomitans strains from 37 periodontitis cases, previously serotyped ... | 2015 | 26529053 |
| differential expression of cc chemokines (ccls) and receptors (ccrs) by human t lymphocytes in response to different aggregatibacter actinomycetemcomitans serotypes. | in aggregatibacter actinomycetemcomitans, different serotypes have been described based on lps antigenicity. recently, our research group has reported a differential immunogenicity when t lymphocytes were stimulated with these different serotypes. in particular, it was demonstrated that the serotype b of a. actinomycetemcomitans has a stronger capacity to trigger th1- and th17-type cytokine production. | 2015 | 26537724 |
| benefits of adjunctive moxifloxacin in generalized aggressive periodontitis: a subgroup analyses in aggregatibacter actinomycetemcomitans-positive/negative patients from a clinical trial. | the aim of the present study was to evaluate the influence of the baseline detection of aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) on the clinical outcomes of moxifloxacin (mox) as an adjunct to full-mouth scaling and root planing (srp) in generalized aggressive periodontitis (gagp). | 2015 | 26538521 |
| java project on periodontal diseases: effect of vitamin c/calcium threonate/citrus flavonoids supplementation on periodontal pathogens, crp and hba1c. | to assess in a periodontally diseased rural population deprived from regular dental care and having poor dietary conditions, the effect of vitamin c/calcium threonate/citrus flavonoids (vitc/ca/fl) supplementation on subgingival microbiota and plasma levels of vitamin c, hba1c and hscrp. | 2015 | 26549279 |
| humoral immune responses to periodontal pathogens in the elderly. | elderly people are thought to be more susceptible to periodontal disease due to reduced immune function associated with aging. however, little information is available on the nature of immune responses against putative periodontal pathogens in geriatric patients. the purpose of this study was to evaluate the serum igg antibody responses to six periodontal pathogens in geriatric subjects. | 2015 | 26550526 |
| occurrence and serotype distribution of aggregatibacter actinomycetemcomitans in subjects without periodontitis in turkey. | to determine the occurrence and serotype distribution of aggregatibacter actinomycetemcomitans in subjects without periodontitis. | 2016 | 26556547 |
| levels of bacterial contamination in fresh extraction sites after a saline rinse. | to determine the level of bacterial contamination in immediate implantation or augmentation sites vs pristine bone, before and after saline rinses. | 2015 | 26574861 |
| photocatalytical antibacterial activity of mixed-phase tio2 nanocomposite thin films against aggregatibacter actinomycetemcomitans. | mixed-phase tio2 nanocomposite thin films consisting of anatase and rutile prepared on commercially pure ti sheets via the electrochemical anodization and annealing treatments were investigated in terms of their photocatalytic activity for antibacterial use around dental implants. the resulting films were characterized by scanning electron microscopy (sem), and x-ray diffraction (xrd). the topology was assessed by white light optical profiling (wlop) in the vertical scanning interferometer (vsi) ... | 2015 | 26576430 |
| the in vitro antimicrobial efficacy of pdt against periodontopathogenic bacteria. | periodontitis, an inflammatory disease, is caused by biofilms with a mixed microbial etiology and involves the progressive destruction of the tooth-supporting tissues. a rising number of studies investigate the clinical potential of photodynamic therapy (pdt) as an adjunct during active therapy. the aim of the present review was to evaluate the available literature for the in vitro antimicrobial efficacy of photodynamic therapy focusing on the periodontopathogenic bacteria aggregatibacter actino ... | 2015 | 26580607 |
| characterization of a. actinomycetemcomitans strains in subgingival samples from periodontitis subjects in morocco. | aggregatibacter actinomycetemcomitans, specially its highly leucotoxic strain (jp2 clone), represents an etiological factor for the onset and progression of aggressive types of periodontitis. the aims of this investigation were to investigate the most relevant periodontal pathogens in the subgingival microbiota of periodontitis patients from morocco and to describe the clinical and microbiological characteristics of subjects positive for a. actinomycetemcomitans, including serotype, leukotoxin g ... | 2016 | 26592810 |
| bacterial inactivation/sterilization by argon plasma treatment on contaminated titanium implant surfaces: in vitro study. | surface treatment by argon plasma is widely used as the last step of the manufacturing process of titanium implant fixtures before their sterilization by gamma rays. the possibility of using such a technology in the daily clinical practice is particularly fascinating. the aim of the present study was to assess the effects of the argon plasma treatment on different titanium implant surfaces previously exposed in vitro to bacterial contamination. | 2016 | 26595834 |
| porphyromonas gingivalis fim-a genotype distribution among colombians. | porphyromonas gingivalis is associated with periodontitis and exhibit a wide array of virulence factors, including fimbriae which is encoded by the fima gene representing six known genotypes. | 2015 | 26600627 |
| comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a split mouth clinical and microbiological study. | harnessing mother nature's bountiful remedies for rejuvenation has been in vogue since time immemorial. turmeric contains the polyphenol curcumin in its rhizome. it produces reactive oxygen species (ros) with visible light irradiation as photodynamic therapy (pdt) - which validates its use in the treatment of periodontitis. this study compares curcumin and curcumin pdt as an adjunct to conventional scaling and root planing (srp) with srp alone in the treatment of patients with chronic periodonti ... | 2015 | 26604595 |
| changes in salivary periodontal pathogens after orthodontic treatment: an in vivo prospective study. | to analyze the initial changes in salivary levels of periodontal pathogens after orthodontic treatment with fixed appliances. | 2016 | 26606331 |
| neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease. | cardiovascular diseases are chronic inflammatory diseases that affect a large segment of society. coronary heart disease (chd), the most common cardiovascular disease, progresses over several years and affects millions of people worldwide. chronic infections may contribute to the systemic inflammation and enhance the risk for chd. periodontitis is one of the most common chronic infections that affects up to 50% of the adult population. under inflammatory conditions the activation of endogenous d ... | 2016 | 26608308 |
| periodontitis prevalence and serum antibody reactivity to periodontal bacteria in primary sjögren's syndrome: a pilot study. | the aims of this study were as follows: (i) to assess the prevalence of periodontitis among patients with primary sjögren's syndrome (pss) and comparator groups of patients with rheumatoid arthritis (ra) and osteoarthritis (oa). (ii) to perform a pilot study to compare serum antibody responses to 10 oral/periodontal bacteria in these patient groups and a historical comparator group of patients with periodontitis. | 2016 | 26646777 |
| effect of periodontitis on adiponectin, c-reactive protein, and immunoglobulin g against porphyromonas gingivalis in thai people with overweight or obese status. | obesity and periodontitis are associated with an inflammatory background. inflammatory mediators involved may have reciprocal effects on one another. in this study, the levels of inflammatory mediators implicated in overweight or obese status and periodontitis are simultaneously evaluated. | 2016 | 26654348 |
| the jp2 genotype of aggregatibacter actinomycetemcomitans and marginal periodontitis in the mixed dentition. | to perform a cross-sectional study on the carrier frequency of jp2 and non-jp2 genotypes of a. actinomycetemcomitans in moroccan school children and relate the presence of these genotypes to the periodontal status in the mixed dentition. | 2016 | 26659719 |
| short-term microbiological effects of photodynamic therapy in non-surgical periodontal treatment of residual pockets: a split-mouth rct. | photodynamic therapy (pdt) has been used as a therapeutic alternative to treat periodontitis, especially in challenging sites that require additional periodontal therapy such as residual pockets. the aim of this split-mouth randomized trial was to evaluate the microbiological and clinical effects of pdt on non-surgical treatment of unresponsive pockets. | 2016 | 26660720 |
| maresin 1 biosynthesis and proresolving anti-infective functions with human-localized aggressive periodontitis leukocytes. | localized aggressive periodontitis (lap) is a distinct form of early-onset periodontitis linked to periodontal infection with uncontrolled inflammation and leukocyte-mediated tissue destruction. the resolution of inflammation is an active process orchestrated by specialized proresolving lipid mediators (spms). since the level of the maresin pathway marker 14-hydroxy-docosahexaenoic acid (14-hdha) was lower in activated peripheral blood from lap patients, we investigated the maresin 1 (mar1) bios ... | 2015 | 26667839 |
| evaluation of the efficacy of a probiotic drink containing lactobacillus casei on the levels of periodontopathic bacteria in periodontitis: a clinico-microbiologic study. | this study was designed to evaluate whether the oral administration of lactobacilli could change the bacterial population in subgingival plaque. | 2015 | 26672414 |
| in vitro antibacterial activity of ethanolic extract of morus alba leaf against periodontal pathogens. | antibiotic resistance is a major problem with inadvertent usage. thus, there is a need to search for new antimicrobial agents of herbal origin to combat antibiotic resistance. one such plant is morus alba which has a long history of medicinal use in traditional chinese medicine. | 2015 | 26672427 |
| scaling and root planning, and locally delivered minocycline reduces the load of prevotella intermedia in an interdependent pattern, correlating with symptomatic improvements of chronic periodontitis: a short-term randomized clinical trial. | to evaluate the respective or combinatory efficacy of locally delivered 2% minocycline (mo), and scaling and root planning (srp) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating chronic periodontitis (cp). | 2015 | 26676022 |
| detection of antimicrobial activity of banana peel (musa paradisiaca l.) on porphyromonas gingivalis and aggregatibacter actinomycetemcomitans: an in vitro study. | banana is used widely because of its nutritional values. in past, there are studies that show banana plant parts, and their fruits can be used to treat the human diseases. banana peel is a part of banana fruit that also has the antibacterial activity against microorganisms but has not been studied extensively. since, there are no studies that relate the antibacterial activity of banana peel against periodontal pathogens. hence, the aim of this study is to determine the antimicrobial activity of ... | 2015 | 26681854 |
| evaluation of antimicrobial action of carie care™ and papacarie duo™ on aggregatibacter actinomycetemcomitans a major periodontal pathogen using polymerase chain reaction. | in the present scenario, we are made available with chemomechanical caries removal system containing a natural proteolytic enzyme for the ease in the excavation of infected dentine. the additive action for these agents is providing antimicrobial and anti-inflammatory properties. | 2017 | 26681861 |
| antimicrobial activity of protamine against oral microorganisms. | protamine is an arginine-rich polycationic protein extracted from sperm cells of vertebrates including fishes such as salmon. the purpose of this study was to investigate the suppressive effects of protamine on the growth of oral pathogens for possible usage in dental materials. minimal inhibitory concentration (mic) and minimal bactericidal concentration (mbc) were determined by the microdilution method. twelve strains of oral viridans streptococci, actinomyces naeslundii, actinomyces odontolyt ... | 2015 | 26699859 |
| systematic review of the in vitro effects of statins on oral and perioral microorganisms. | statins are medications administered orally and are widely used for lowering the blood cholesterol level. the aim of this study was to investigate the effects of orally administered statins on microorganisms infecting oral and perioral tissues. we performed a systematic review of published studies of the in vitro antimicrobial effects of statins on bacteria, viruses, and fungi, and searched pubmed, web of science, cochrane central, and google scholar. studies show that most statins exhibit antim ... | 2016 | 26718458 |
| in vitro behavior of poly-lactic-co-glycolic acid microspheres containing minocycline, metronidazole, and ciprofloxacin. | in the present study, we aimed to fabricate poly-lactic-co-glycolic acid (plga) microspheres containing a mixture of three antibiotics-minocycline, metronidazole, and ciprofloxacin (mmc)-to assess their efficacy and properties. | 2016 | 26748575 |
| effect of low-level laser therapy as an adjuvant in the treatment of periodontitis induced in rats subjected to 5-fluorouracil chemotherapy. | this study aimed to assess the effect of multiple sessions of a low-level laser therapy (lllt) adjuvant to scaling and root planing (srp) on the treatment of experimental periodontitis (ep) in rats treated with 5-fluorouracil (5-fu). | 2016 | 26750739 |
| strontium-substituted bioactive glasses in vitro osteogenic and antibacterial effects. | bioactive glass forms a bone mineral apatite interface and can be engineered to promote optimal bone regeneration. strontium (sr(2+)) stimulates osteoblast and inhibits osteoclast activities in vitro, and is used clinically as a treatment for osteoporosis. dental bone defect repair requires rapid bone formation for early osseointegration but, can be subject to infection. the aim of this study was to investigate the osteogenic and antibacterial effects of strontium-substituted bioactive glasses i ... | 2016 | 26777094 |
| total antioxidant capacity and total oxidant status in saliva of periodontitis patients in relation to bacterial load. | the detection of salivary biomarkers has a potential application in early diagnosis and monitoring of periodontal inflammation. however, searching sensitive salivary biomarkers for periodontitis is still ongoing. oxidative stress is supposed to play an important role in periodontitis progression and tissue destruction. in this cross-sectional study, we investigated total antioxidant capacity (tac) and total oxidant status (tos) in saliva of periodontitis patients compared to healthy controls and ... | 2015 | 26779448 |
| effect of photodynamic therapy adjunct to scaling and root planing in periodontitis patients: a randomized clinical trial. | a randomized split-mouth controlled clinical trial was conducted to evaluate the efficacy of photodynamic therapy (pdt) in reducing aggregatibacter actinomycetemcomitans (aa) in periodontitis patients. | 2016 | 26780271 |
| characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of aggregatibacter actinomycetemcomitans. | natural antibodies are predominantly antibodies of the igm isotype present in the circulation of all vertebrates that have not been previously exposed to exogenous antigens. they are often directed against highly conserved epitopes and bind to ligands of varying chemical composition with low affinity. in this study we cloned and characterized a natural mouse monoclonal igm antibody selected by binding to malondialdehyde acetaldehyde epitopes on low-density lipoprotein (ldl). interestingly, the i ... | 2016 | 26786003 |
| salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-mo prospective multicenter cohort study. | a diagnosis of periodontitis progression is presently limited to clinical parameters such as attachment loss and radiographic imaging. the aim of this multicenter study was to monitor disease progression in patients with chronic periodontitis during a 24-mo follow-up program and to evaluate the amount of bacteria in saliva and corresponding igg titers in serum for determining the diagnostic usefulness of each in indicating disease progression and stability. | 2016 | 26791469 |
| inner-membrane protein morc is involved in fimbriae production and biofilm formation in aggregatibacter actinomycetemcomitans. | fimbrial subunit synthesis, secretion and assembly on the surface of the periodontal pathogen aggregatibacter actinomycetemcomitans are essential for biofilm formation. a recent quantitative proteomics study employing an afimbriated strain and a developed mutant isogenic for the inner-membrane protein morphogenesis protein c (morc) revealed that the abundance of the proteins of the fimbrial secretion apparatus in the membrane is dependent on morc. to investigate further the relationship between ... | 2016 | 26796329 |
| [role of platelet-activating factor receptor in adhesion and invasion of aggregatibacter actinomycetemcomitans in human umbilical vein endothelial cells]. | to explore the role of platelet-activating factor receptor (pafr) in adhesion and invasion of phospho- rylcholine (pc)-positive aggregatibacter actinomycetemcomitans in cultured human umbilical vein endothelial cells (huvec). | 2016 | 26806742 |
| oral and endotracheal tubes colonization by periodontal bacteria: a case-control icu study. | periodontal infection is a possible risk factor for respiratory disorders; however, no studies have assessed the colonization of periodontal pathogens in endotracheal tubes (et). this case-control study analyzed whether periodontal pathogens are able to colonize et of dentate and edentulous patients in intensive care units (icu) and whether oral and et periodontal pathogen profiles have any correlation between these patients. we selected 18 dentate and 18 edentulous patients from 78 eligible icu ... | 2016 | 26810057 |
| differential expression of cc chemokines (ccls) and receptors (ccrs) by human t lymphocytes in response to different aggregatibacter actinomycetemcomitans serotypes. | in aggregatibacter actinomycetemcomitans, different serotypes have been described based on lps antigenicity. recently, our research group has reported a differential immunogenicity when t lymphocytes were stimulated with these different serotypes. in particular, it was demonstrated that the serotype b of a. actinomycetemcomitans has a stronger capacity to trigger th1- and th17-type cytokine production. objective this study aimed to quantify the expression of different cc chemokines (ccls) and re ... | 2016 | 26814460 |
| actinobacillus actinomycetemcomitans keratitis after glaucoma infiltration surgery: a clinical report and literature review. | actinobacillus actinomycetemcomitans infection is a rare and easily misdiagnosed ocular disease. in this article, the authors report a chronic, purulent, and difficult-to-treat case of a actinomycetemcomitans keratitis following a glaucoma infiltration surgery.a 56-year-old man with a long-standing history of open-angle glaucoma in both eyes presented with a 12-week history of ocular pain, redness, and blurred vision in his right eye. he underwent a glaucoma infiltration surgery in his right eye ... | 2016 | 26817919 |
| bioactive glass combined with bisphosphonates provides protection against biofilms formed by the periodontal pathogen aggregatibacter actinomycetemcomitans. | biofilms play a pivotal role in the progression of periodontitis and they can be treated with antiseptics (i.e. chlorhexidine) or antibiotics, but these therapeutic alternatives are unable of ameliorating periodontal alveolar bone loss, which has been, on the other hand, successfully treated with bone-preserving agents. the improved bone formation achieved in animal models by the combination of two such agents: bioactive glass (bag) and bisphosphonates has attracted the interest for further expl ... | 2016 | 26854428 |
| diabetic lactoferrin deficient mice demonstrates greater susceptibility to experimental periodontal disease. | the objective of this study is to detrmine whether alloxan-induced diabetic lactoferrin knockout (lfko(-/-)) mice are more susceptible to periodontal disease caused by aggregatibacter actinomycetemcomitans compared to the diabetic wild-type (wt) mice. diabetes was induced in mice by a single dose of alloxan (60 mg/kg) injected intravenously. mice were categorized as diabetic when blood glucose levels >250 mg/dl were measured on the 7(th) day after the injection. periodontal disease was experimen ... | 2017 | 26855973 |
| microbiological distribution of six periodontal pathogens between untreated italian and dutch periodontal patients. | to compare prevalence and microbial load of six periodontal pathogens between italian and dutch patients affected by chronic periodontitis, using oligonucleotide probe technology. | 2016 | 26870849 |
| inverse association of plasma igg antibody to aggregatibacter actinomycetemcomitans and high c-reactive protein levels in patients with metabolic syndrome and periodontitis. | the association between clinically diagnosed periodontitis, a common chronic oral infection, and metabolic syndrome has been previously reported. the aim of this study was to investigate the association of plasma igg levels against aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, and prevotella intermedia, c-reactive protein, and periodontal status with metabolic syndrome. plasma igg levels and c-reactive protein were measured by enzyme-linked immunosorbent assay, and salivary le ... | 2016 | 26871443 |
| antimicrobial effects of commensal oral species are regulated by environmental factors. | the objectives of this study are to identify oral commensal species which can inhibit the growth of the main periodontopathogens, to determine the antimicrobial substances involved in these inhibitory activities and to evaluate the influence of environmental factors on the magnitude of these inhibitions. | 2016 | 26875613 |
| aggregatibacter actinomycetemcomitans-induced aim2 inflammasome activation is suppressed by xylitol in differentiated thp-1 macrophages. | aggressive periodontitis is characterized by rapid destruction of periodontal tissue caused by aggregatibacter actinomycetemcomitans. interleukin (il)-1β is a proinflammatory cytokine, and its production is tightly regulated by inflammasome activation. xylitol, an anticaries agent, is anti-inflammatory, but its effect on inflammasome activation has not been researched. this study investigates the effect of xylitol on inflammasome activation induced by a. actinomycetemcomitans. | 2016 | 26876350 |
| macrophage polarization in response to oral commensals and pathogens. | macrophages have been identified in the periodontium. data have phenotypically described these cells, demonstrated changes with progressing periodontal disease, and identified their ability to function in antigen-presentation critical for adaptive immune responses to individual oral bacterium. recent evidence has emphasized an important role for the plasticity of macrophage phenotypes, not only in the resulting function of these cells in various tissues, but also clear differences in the stimula ... | 2016 | 26884502 |
| quantitative pcr studies of aggregatibacter actinomycetemcomitans and treponema denticola/tanerella forsythensis complex as etiological factors of chronic periodontitis. | real-time quantitative pcr (dentofl or kit) was used to detect dna of periodontal pathogens in specimens from 92 patients with chronic periodontitis and from a control sample of 12 normal subjects. a bimodal distribution of patients by periodontium colonization with a. actinomycetemcomitans, p. gingivalis, p. intermedia, t. forsythensis, and t. denticola was demonstrated. a new approach to interpretation of the results of quantitative evaluation of periodontal pathogens, including the notion of ... | 2016 | 26899837 |
| early colonization of the oral cavity in 6- and 12-month-old infants by cariogenic and periodontal pathogens: a case-control study. | the colonization of the oral cavity by cariogenic and periodontal pathogens occurs earlier than previously thought. this study aimed to identify the presence and quantity of representative cariogenic and periodontal pathogens in the oral cavities of 6- and 12-month olds and to evaluate the influence of c-section delivery on early streptococcus mutans (sm) colonization of the oral cavity. the research cohort was composed of 59 infants (35 infants were delivered vaginally and 24 via c-section) and ... | 2016 | 26914065 |
| effect of roselle calyx extract on in vitro viability and biofilm formation ability of oral pathogenic bacteria. | to investigate the effect of the roselle calyx extract (rce) (hibiscus sabdariffa l.) on the in vitro viability and biofilm formation ability of oral pathogenic bacteria. | 2016 | 26919939 |
| a bacterial-biofilm-induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid-associated protein. | periodontal disease exemplifies a chronic and recurrent infection with a necessary biofilm component. mucosal inflammation is a hallmark response of the host seen in chronic diseases, such as colitis, gingivitis, and periodontitis (and the related disorder peri-implantitis). we have taken advantage of our recently developed rat model of human peri-implantitis that recapitulates osteolysis, the requirement of biofilm formation, and the perpetuation of the bona fide disease state, to test a new th ... | 2017 | 26931773 |
| influence of a triclosan toothpaste on periodontopathic bacteria and periodontitis progression in cardiovascular patients: a randomized controlled trial. | triclosan/copolymer toothpaste is effective in controlling plaque and gingivitis and in slowing the progression of periodontitis. this study describes its influence on microbiological and clinical outcomes, over a 5-year period, in patients with established cardiovascular disease (cvd). | 2017 | 26932733 |
| comparison of the detection of periodontal pathogens in bacteraemia after tooth brushing by culture and molecular techniques. | the prevalence and amounts of periodontal pathogens detected in bacteraemia samples after tooth brushing-induced by means of four diagnostic technique, three based on culture and one in a molecular-based technique, have been compared in this study. | 2016 | 26946197 |
| the comparative evaluation of the antimicrobial effect of propolis with chlorhexidine against oral pathogens: an in vitro study. | this study aimed to compare the antimicrobial effectiveness of ethanolic extract of propolis (eep) to chlorhexidine gluconate (chx) on planktonic streptococcus mutans, streptococcus sobrinus, lactobacillus acidophilus, lactobacillus salivarius subsp. salivarius, aggregatibacter actinomycetemcomitans, prevotella intermedia, porphyromonas gingivalis, staphylococcus aureus, enterococcus faecalis, actinomyces israelii, candida albicans, and their single-species biofilms by agar dilution and broth mi ... | 2016 | 26949701 |
| genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease. | genome-wide association studies (gwas) of chronic periodontitis (cp) defined by clinical criteria alone have had modest success to-date. here, we refine the cp phenotype by supplementing clinical data with biological intermediates of microbial burden (levels of eight periodontal pathogens) and local inflammatory response (gingival crevicular fluid il-1β) and derive periodontal complex traits (pcts) via principal component analysis. pcts were carried forward to gwas (∼2.5 million markers) to iden ... | 2016 | 26962152 |
| profound effects of aggregatibacter actinomycetemcomitans leukotoxin mutation on adherence properties are clarified in in vitro experiments. | leukotoxin (ltx) is a prominent virulence factor produced by aggregatibacter actinomycetemcomitans, an oral microorganism highly associated with aggressive periodontitis. ltx compromises host responsiveness by altering the viability of neutrophils, lymphocytes, and macrophages. previously, we developed a rhesus (rh) monkey colonization model designed to determine the effect of virulence gene mutations on colonization of a. actinomycetemcomitans. unexpectedly, an a. actinomycetemcomitans leukotox ... | 2016 | 26977924 |
| complete genome sequence of aggregatibacter actinomycetemcomitans serotype g strain num4039 (jcm 30399). | aggregatibacter actinomycetemcomitans is considered to be a major etiological agent of aggressive periodontitis and includes serotype a to g strains. we herein report the first complete genome sequence of a. actinomycetemcomitans serotype g strain num4039. the genome is 2,382,853 bp in length with a g+c content of 44.34%. | 2016 | 26988057 |
| arthritis-induced alveolar bone loss is associated with changes in the composition of oral microbiota. | rheumatoid arthritis (ra) and periodontitis (pd) are chronic inflammatory disorders that cause bone loss. pd tends to be more prevalent and severe in ra patients. previous experimental studies demonstrated that ra triggers alveolar bone loss similarly to pd. the aim of this study was to investigate if arthritis-induced alveolar bone loss is associated with modification in the oral microbiota. checkerboard dna-dna hybridization was employed to analyze forty oral bacterial species in 3 groups of c ... | 2016 | 26996070 |
| antibacterial effect of silver (i) carbohydrate complexes on oral pathogenic key species in vitro. | it was the aim of this study to evaluate the antibacterial impact of two silver(i) carbohydrate complexes with tripodal thioglycosides, namely tris[2-(β-d-thio-glucopyranosyl)ethyl]-amine-silver(i)-nitrate (3) and tris[2-(α-d-thio-manno-pyranosyl)ethyl]-amine-silver(i)-nitrate (4), on five oral pathogenic bacterial strains. furthermore, cytocompatibility was tested using human gingival fibroblasts (hgf). | 2016 | 27009305 |
| accuracy of commercial kits and published primer pairs for the detection of periodontopathogens. | despite the input of microbiome research, a group of 20 bacteria continues to be the focus of periodontal diagnostics and therapy. the aim of this study was to compare three commercial kits and laboratory-developed primer pairs for effectiveness in detecting such periodontopathogens. | 2016 | 27020914 |
| inhibition of bacterial toxin activity by the nuclear stain, draq5™. | the repeats-in-toxin family of toxins includes proteins produced by gram negative bacteria such as escherichia coli (α-hemolysin), bordetella pertussis (adenylate cyclase toxin), and aggregatibacter actinomycetemcomitans (ltxa), which contribute to the pathogenesis of these organisms by killing host cells. in the case of ltxa produced by a. actinomycetemcomitans, white blood cells are targeted, allowing the bacteria to avoid clearance by the host immune system. in its association with target cel ... | 2016 | 27039399 |
| efficacy of photodynamic therapy and lasers as an adjunct to scaling and root planing in the treatment of aggressive periodontitis - a clinical and microbiologic short term study. | aggressive periodontitis comprises a group of rare, severe, rapidly progressive form of periodontitis. conventional treatment includes mechanical debridement augmented with adjunctive antimicrobial therapy. development of antibiotic resistance has led to use of lasers. photodynamic therapy (pdt) is a novel non-invasive therapeutic approach with increased site and pathogen specificity. this study compares pdt and lasers as an adjunct to conventional scaling in the treatment of patients with aggre ... | 2016 | 27042576 |
| alteration of homeostasis in pre-osteoclasts induced by aggregatibacter actinomycetemcomitans cdt. | the dysbiotic microbiota associated with aggressive periodontitis includes aggregatibacter actinomycetemcomitans, the only oral species known to produce a cytolethal distending toxin (aacdt). give that cdt alters the cytokine profile in monocytic cells, we aimed to test the hypothesis that cdt plays a role in bone homeostasis by affecting the differentiation of precursor cells into osteoclasts. recombinant aacdt was added to murine bone marrow monocytes (bmmc) in the presence or absence of rankl ... | 2016 | 27064424 |
| aggregatibacter actinomycetemcomitans outer membrane protein 29 (omp29) induces tgf-β-regulated apoptosis signal in human gingival epithelial cells via fibronectin/integrinβ1/fak cascade. | gingival junctional epithelial cell apoptosis caused by periodontopathic bacteria exacerbates periodontitis. this pathological apoptosis is involved in the activation of transforming growth factor β (tgf-β). however, the molecular mechanisms by which microbes induce the activation of tgf-β remain unclear. we previously reported that aggregatibacter actinomycetemcomitans (aa) activated tgf-β receptor (tgf-βr)/smad2 signalling to induce epithelial cell apoptosis, even though aa cannot bind to tgf- ... | 2016 | 27121139 |
| hacek endocarditis: a review. | the hacek group, referring to haemophilus spp., aggregatibacter actinomycetemcomitans, cardiobacterium hominis, eikenella corrodens, and kingella kingae, is a rare cause of infective endocarditis (ie). it causes the majority of gram-negative endocarditis cases and has an excellent prognosis and simple management if properly identified. however, delay in diagnosis and associated complications can render the infection fatal. | 2016 | 27124204 |
| anti-microbial activity of tulsi {ocimum sanctum (linn.)} extract on a periodontal pathogen in human dental plaque: an invitro study. | tulsi is a popular healing herb in ayurvedic medicine. it is widely used in the treatment of several systemic diseases because of its anti-microbial property. however, studies documenting the effect of tulsi on oral disease causing organisms are rare. hence, an attempt was made to determine the effect of tulsi on a periodontal microorganism in human dental plaque. | 2016 | 27135002 |
| comparative evaluation of antimicrobial activity of pomegranate-containing mouthwash against oral-biofilm forming organisms: an invitro microbial study. | pomegranate is considered "a pharmacy unto itself". hydrolysable tannins called punicalagins which have free scavenging properties are the most abundant polyphenols found in pomegranate-containing mouthwash. | 2016 | 27135005 |
| detection of five potentially periodontal pathogenic bacteria in peri-implant disease: a comparison of pcr and real-time pcr. | the aim of this study was to compare the microbial analysis methods of polymerase chain reaction (pcr) and real-time pcr (rt-pcr) in terms of detection of five selected potentially periodontal pathogenic bacteria in peri-implant disease. therefore 45 samples of healthy, mucositis and peri-implantitis (n = 15 each) were assessed according to presence of the following bacteria using pcr (dna-strip technology) and rt-pcr (fluorescent dye sybr green-system): aggregatibacter actinomycetemcomitans (aa ... | 2016 | 27142589 |
| occurrence of aggregatibacter actinomycetemcomitans in indian chronic periodontitis patients and periodontally healthy adults. | aggregatibacter actinomycetemcomitans (aa), an important primary periodontal pathogen, is known for its strong virulence characteristics that cause periodontal disease. we investigated aa occurrence in indian individuals using culture and 16 s rdna polymerase chain reaction (pcr). | 2017 | 27143824 |
| antimicrobial efficacy of tulsi leaf (ocimum sanctum) extract on periodontal pathogens: an in vitro study. | periodontitis is an infection of the periodontal complex with severe forms of disease associated with specific bacteria colonizing the subgingival area. widespread use of drugs has resulted in the emergence of side effects, uncommon infections, and resistance. plant medicine like tulsi has been used in many clinical conditions, and it appears to be a suitable alternative to manage conditions affecting the oral cavity. hence, the objective was to assess the in vitro antimicrobial activity of tuls ... | 2017 | 27143825 |