Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| a "silent" nucleotide substitution in exon 4 is responsible for the "alternative expression" of hla-a*01:01:38l through aberrant splicing. | a welsh bone marrow donor registry donor was serologically typed, using both alloantisera and monoclonal antibodies, as human leukocyte antigen (hla)-a2, a-, but typed by polymerase chain reaction sequence-specific priming as hla-a*01, a*02. full gene sequencing of the a*01 separated allele indicated an apparently normal a*01:01:01:01 apart from a silent change at nucleotide 705 in exon 4, codon 211 (alanine: normally gcg but gca in this donor). sequence analysis of the amplified a*01 allele in ... | 2011 | 21741421 |
| fc?riiia (cd16) induction on human t lymphocytes and cd16pos t-lymphocyte amplification. | during serial assays designed to amplify natural killer (nk) cells in vitro, we observed that when peripheral blood mononuclear cells (pbmcs) from human immunodeficiency virus positive (hiv+) patients were stimulated for 2 weeks with an epstein-barr virus-infected b lymphoblastic cell line and interleukin-2, a well known procedure to amplify nk cells in vitro, 44.4±18% cd3cd16 t lymphocytes were recovered together with nk cells, of which 78.2% expressed an aß t-cell receptor (tcr). to identify t ... | 2011 | 21760529 |
| inhibitory molecules that regulate expansion and restoration of hcv-specific cd4+ t cells in patients with chronic infection. | background & aims: inhibitory receptors such as programmed death (pd)-1 and cytotoxic t lymphocyte-associated antigen (ctla)-4 mediate cd8+ t-cell exhaustion during chronic viral infection, but little is known about roles in dysfunction of cd4+ t cells. methods: we investigated the functions of inhibitory molecules on hepatitis c virus (hcv)-, influenza-, and epstein-barr-virus (ebv)-specific cd4+ t cells in patients with chronic infections, compared with patients that resolve hcv infection and ... | 2011 | 21763239 |
| salivary epstein-barr virus dna level in patients with nasopharyngeal carcinoma following radiotherapy. | nasopharyngeal carcinoma (npc) is a solid tumor closely associated with epstein-barr virus (ebv) infection. the purpose of this investigation was to detect and quantify the ebv dna level in salivary samples of npc patients following treatment using real-time pcr. a total of 175 consecutive newly diagnosed npc patients' whole saliva samples were collected before treatment, and the ebv dna level was measured by real-time pcr, with the primers and probe targeting the bamhi-w region of the ebv genom ... | 2011 | 21767975 |
| piggybac-mediated cancer immunotherapy using ebv-specific cytotoxic t-cells expressing her2-specific chimeric antigen receptor. | epstein-barr virus (ebv)-specific cytotoxic t lymphocytes (ctls) can be modified to function as heterologous tumor directed effector cells that survive longer in vivo than tumor directed t cells without virus specificity, due to chronic stimulation by viral antigens expressed during persistent infection in seropositive individuals. we evaluated the nonviral piggybac (pb) transposon system as a platform for modifying ebv-ctls to express a functional human epidermal growth factor receptor 2-specif ... | 2011 | 21772253 |
| aerobic fitness is associated with lower proportions of senescent blood t-cells in man. | senescent t-cells accumulate with age, lowering the naïve t-cell repertoire and increasing host infection risk. as this response is likely to be influenced by certain lifestyle factors, we examined the association between aerobic fitness (vo(2max)) and the age-related accumulation of senescent t-cells. blood lymphocytes from 102 healthy males (18-61yr) were analyzed for klrg1, cd57, cd28, cd45ra, cd45ro surface expression on cd4+ and cd8+ t-cells by 4-color flow cytometry. advancing age (yr) was ... | 2011 | 21784146 |
| bortezomib-induced epstein-barr virus and kaposi sarcoma herpesvirus lytic gene expression: oncolytic strategies. | purpose of review: gamma herpesviruses (ghvs) are responsible for a substantial proportion of virus-associated human cancers, particularly in immunocompromised individuals. methods that employ lytic activation of viruses latently infecting tumors represent a novel strategy of antineoplastic therapy. recent findings: the proteasome inhibitor, bortezomib, has been shown to be a potent activator of ghv lytic cycle and has demonstrated activity in case reports of ghv-related malignancies. although i ... | 2011 | 21788895 |
| expression of ebv encoded viral rna 1, 2 and anti- inflammatory cytokine (interleukin-10) in ffpe lymphoma specimens: a preliminary study for diagnostic implication in pakistan. | abstract: background: epstein barr virus (ebv) plays a significant role as a cofactor in the process of tumorigenesis and has consistently been associated with a variety of malignancies. ebv encoded rnas (eber1 and eber2) are the most abundant viral transcripts in latently ebv-infected cells and their role in viral infection is still unclear. formalin fixed paraffin embedded (ffpe) tissues of surgically removed carcinoma biopsies are widely available form but have never been exploited for expres ... | 2011 | 21791113 |
| epstein-barr virus lmp1 c-terminal activating region-3 contributes to lmp1-mediated cellular migration via its interaction with ubc9. | epstein-barr virus (ebv) latent membrane protein (lmp)-1, the principal viral oncoprotein and a member of the tnfr superfamily, is a constitutively active membrane signaling protein that regulates multiple signal transduction pathways via its c-terminal activating regions (ctar) -1 and -2, and the less studied ctar3. because protein sumoylation among other post-translational modifications may regulate many signaling pathways induced by lmp1, we investigated whether during ebv latency lmp1 regula ... | 2011 | 21795333 |
| lymphoepithelial-like carcinoma of the uterine cervix; a case report. | lymphoepithelioma-like carcinoma (lelc) of the uterine cervix is a rare variant of squamous cell carcinoma of the uterine cervix. this tumor is characterized by nests of poorly differentiated epithelial cells surrounded by a prominent lymphocytic infiltration. despite the poorly differentiated pathological findings, it appears to have a better outcome than the usual squamous cell carcinoma of the uterine cervix. therefore, it is quite important to differentiate this tumor from poorly differentia ... | 2011 | 21797126 |
| [detection of ebv-lmp1 antibodies in sera and clinical significance in the patients with nasopharyngeal carcinoma]. | to detect the levels of epstein-barr virus (ebv) latent membrane protein 1 antibodies (lmp1-ab) in nasopharyngeal carcinoma (npc)sera and discuss the clinical significance of this test in diagnosis, prognosis, and immune-targeted therapy of npc. | 2011 | 21805833 |
| concurrent gastric malt and hodgkin lymphoma : a case report. | this report describes a 60-year-old man with concurrent gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (malt lymphoma) and classical hodgkin lymphoma (chl). atypical, medium-sized, lymphoid cells proliferated in the mucosa to muscular layer of the stomach showing a lymphoepithelial lesion; admixed with hodgkin/reed-sternberg (hrs) cells and an inflammatory cell background. malt lymphoma cells expressed cd20, cd79a, pax5, and bob.1, and hrs cells expressed cd30, cd ... | 2011 | 21813545 |
| microorganisms and valve tissue/ demonstration of chlamydophila pneumoniae, mycoplasma pneumoniae, cytomegalovirus, and epstein-barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction. | 2011 | 21827993 | |
| herpesvirus carriage in saliva and posttreatment apical periodontitis: searching for association. | objective: herpesvirus infection can cause immunosuppression and then act as a modifier of apical periodontitis, influencing the disease severity and response to treatment. the purpose of this study was to investigate if herpesvirus infection, as inferred by salivary carriage, may influence the endodontic treatment outcome. study design: the study population included 72 patients who had root canals treated more than 1 year previously because of necrotic pulps and apical periodontitis. at the fol ... | 2011 | 21831677 |
| epstein-barr virus and multiple sclerosis. | this review of the considerable evidence linking epstein-barr virus (ebv) infection to risk and disease progression in multiple sclerosis (ms) builds on the background to the virus and its interactions with the human host available in the online supplement (see supplement, available online only). the evidence for a similarity in the geographic patterns of occurrence of ms and ebv infection (with infectious mononucleosis or ebv specific serology used as surrogate markers), when reviewed criticall ... | 2011 | 21836034 |
| real-time pcr detection of human herpesvirus 1-5 in patients lacking clinical signs of a viral cns infection. | infections of the central nervous system (cns) with herpes- or enterovirus can be self-limiting and benign, but occasionally result in severe and fatal disease. the polymerase chain reaction (pcr) has revolutionized the diagnostics of viral pathogens, and by multiple displacement amplification (mda) prior to real-time pcr the sensitivity might be further enhanced. the aim of this study was to investigate if herpes- or enterovirus can be detected in cerebrospinal fluid (csf) from patients without ... | 2011 | 21849074 |
| epstein-barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines. | recent studies suggest the existence of cancer stem cells (csc) and cancer progenitor cells (cpc), although strict definitions of neither csc nor cpc have been developed. we have produced evidence that the principal oncoprotein of epstein-barr virus (ebv), latent membrane protein 1 (lmp1), which is associated with human malignancies, especially nasopharyngeal carcinoma (npc), promotes tumor cell invasion and metastasis, as well as the epithelial-mesenchymal transition (emt). however, whether lmp ... | 2011 | 21849440 |
| Latent membrane protein 1 is dispensable for Epstein-Barr virus replication in human embryonic kidney 293 cells. | Epstein Barr Virus (EBV) replicates in oral epithelial cells and gains entry to B-lymphocytes. In B-lymphocytes, EBV expresses a restricted subset of genes, the Latency III program, which converts B-lymphocytes to proliferating lymphoblasts. Latent Membrane Protein 1 (LMP1) and the other Latency III associated proteins are also expressed during virus replication. LMP1 is essential for virus replication and egress from Akata Burkitt Lymphoma cells, but a role in epithelial cell replication has no ... | 2011 | 21853056 |
| The company malaria keeps: how co-infection with Epstein-Barr virus leads to endemic Burkitt lymphoma. | Co-infection with Plasmodium falciparum malaria and Epstein-Barr virus (EBV) are implicated in the cause of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in equatorial Africa. Although the causal association between EBV and eBL has been established, P. falciparum malaria's role is not as clearly defined. This review focuses on how malaria may disrupt EBV persistence and immunity. | 2011 | 21885920 |
| comparison of qiasymphony automated and qiaamp manual dna extraction systems for measuring epstein-barr virus dna load in whole blood using real-time pcr. | automated and manual extraction systems have been used with real-time pcr for quantification of epstein-barr virus [human herpesvirus 4 (hhv-4)] dna in whole blood, but few studies have evaluated relative performances. in the present study, the automated qiasymphony and manual qiaamp extraction systems (qiagen, valencia, ca) were assessed using paired aliquots derived from clinical whole-blood specimens and an in-house, real-time pcr assay. the detection limits using the qiasymphony and qiaamp s ... | 2011 | 21889612 |
| Post-transplant lymphoproliferative disorders and Epstein-Barr virus DNAemia in a cohort of lung transplant recipients. | Post-transplant lymphoproliferative disorders (PTLD) are serious complications in lung transplant recipients. No consensus on EBV DNAemia levels predictive of PTLD has been reached. In addition, in many instances EBV DNAemia is determined in patients with suggestive symptoms only. | 2011 | 21892950 |
| [lymphomatoid granulomatosis revealed by cutaneous lesions]. | lymphomatoid granulomatosis is a rare epstein barr virus (ebv)-related lymphoproliferative disorder. it most frequently involves the lungs, skin and central nervous system and arises preferentially in patients with immune disorders. here we report a case revealed by cutaneous lesions in an immunocompetent patient. | 2011 | 21893233 |
| syk activation of phosphatidylinositol 3-kinase/akt prevents htra2-dependent loss of x-linked inhibitor of apoptosis protein (xiap) to promote survival of epstein-barr virus+ (ebv+) b cell lymphomas. | b cell lymphoma survival requires tonic or ligand-independent signals through activation of syk by the b cell receptor. the epstein-barr virus (ebv) protein latent membrane 2a (lmp2a), a mimic of the b cell receptor, provides constitutive survival signals for latently infected cells through syk activation; however, the precise downstream mechanisms coordinating this survival response in ebv+ b cell lymphomas remain to be elucidated. herein, we assess the mechanism of syk survival signaling in eb ... | 2011 | 21908615 |
| Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma. | Although immunotherapy with Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes (CTLs) can treat EBV-associated Hodgkin and non-Hodgkin lymphoma (HL/NHL), more than 50% of such tumors are EBV negative. We now describe an approach that allows us to consistently generate, in a single line, CTLs that recognize a wide spectrum of nonviral tumor-associated antigens (TAAs) expressed by human HL/NHL, including Survivin, MAGE-A4, Synovial sarcoma X (SSX2), preferentially expressed antigen in melan ... | 2011 | 21915103 |
| Persistent infection drives the development of CD8+ T cells specific for late lytic infection antigens in lymphocryptovirus-infected macaques and Epstein-Barr virus-infected humans. | We examined the CD8(+) T cell repertoire against lytic infection antigens in rhesus macaques persistently infected with the Epstein-Barr virus (EBV)-related lymphocryptovirus (rhLCV). CD8(+) T cells specific for late (L) antigens were detected at rates comparable to those for early antigens and were associated with increasing duration of infection. L antigen-specific CD8(+) T cells were also readily detected in adult, EBV-positive humans. Thus, viral major histocompatibility complex class I (MHC ... | 2011 | 21917961 |
| development of the hybrid sleeping beauty-baculovirus vector for sustained gene expression and cancer therapy. | antiangiogenesis is an appealing anticancer approach but requires continued presence of the antiangiogenic agents, which can be remedied by gene therapy. baculovirus is an emerging gene delivery vector but only mediates transient expression (<7 days); thus, this study primarily aimed to develop a hybrid baculovirus for sustained antiangiogenic gene expression and cancer therapy. we first constructed plasmids featuring adeno-associated virus inverted terminal repeats (aav itrs), orip/epstein-barr ... | 2011 | 21918552 |
| adoptive immunotherapy with virus-specific t cells. | viral infections are still common causes of morbidity and mortality in immunosuppressed patients after allogeneic hematopoietic stem cell transplantation. infections caused by virus such as cytomegalovirus, adenovirus and epstein-barr virus are well-known. in addition, several other viruses such as polyomavirus and human herpesvirus 6 have been recently reported to be causes of significant complications. as the delay in recovery of virus-specific cellular immune response after transplant is asso ... | 2011 | 21925094 |
| Poly(ADP-ribose) polymerase inhibitors combined with external beam and radioimmunotherapy to treat aggressive lymphoma. | To assess the possible radiosensitizing capabilities of two different poly(ADP-ribose) polymerase (PARP) inhibitors in combination with external beam and I-tositumomab in a non-Hodgkin's lymphoma cell line. | 2011 | 21956491 |
| identification of the distinctive type i/xhoi+ strain of epstein-barr virus in gastric carcinoma in peru. | to clarify the reason for the low frequency of epstein-barr virus-associated gastric carcinoma (ebvagc) in peru, despite the high frequency reported in neighboring countries, the distribution of the distinctive ebv (type i/xhoi+) strain in ebvagc and a healthy population was examined. | 2011 | 21965785 |
| Classification of epstein-barr virus-positive gastric cancers by definition of DNA methylation epigenotypes. | Epstein-Barr virus (EBV) is associated with Burkitt lymphoma, nasopharyngeal carcinoma, opportunistic lymphomas in immunocompromised hosts, and a fraction of gastric cancers. Aberrant promoter methylation accompanies human gastric carcinogenesis, though the contribution of EBV to such somatic methylation changes has not been fully clarified. We analyzed promoter methylation in gastric cancer cases with Illumina's Infinium BeadArray and used hierarchical clustering analysis to classify gastric ca ... | 2011 | 21990320 |
| comparison of humoral immune responses to epstein-barr virus and kaposi's sarcoma-associated herpesvirus using a viral proteome microarray. | epstein-barr virus (ebv) is a ubiquitous herpesvirus, and kaposi's sarcoma-associated herpesvirus (kshv) has a restricted seroprevalence. both viruses are associated with malignancies that have an increased frequency in individuals who are coinfected with human immunodeficiency virus type 1 (hiv-1). | 2011 | 21990424 |
| genetic factors influence serological measures of common infections. | antibodies against infectious pathogens provide information on past or present exposure to infectious agents. while host genetic factors are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. here we test whether antibody levels for 13 common infections are significantly heritable. | 2011 | 21996708 |
| [T-cell large granular lymphocyte leukemia after autologous peripheral blood stem cell transplantation for malignant lymphoma-report of three cases and a review of the literature]. | There have been only three reports in the literature of T-cell large granular lymphocyte (T-LGL) leukemia occurring after autologous peripheral stem cell transplantation (APBSCT). We describe 3 patients in whom a transient monoclonal T-LGL developed after APBSCT for malignant lymphoma. Case 1: A 58-year-old man with peripheral T-cell lymphoma in second complete remission (CR) who underwent APBSCT. Case 2: A 51-year-old man with follicular lymphoma in second CR who underwent APBSCT. Case 3: A 65- ... | 2011 | 21996977 |
| clinical characteristics of patients with epstein barr virus in cerebrospinal fluid. | the role of epstein-barr (ebv) virus in central nervous system (cns) infections is not fully resolved. it is clearly associated with lymphoproliferative disease of immunosuppressed persons, and may cause encephalitis. | 2011 | 22018204 |
| exhausted cytotoxic control of epstein-barr virus in human lupus. | systemic lupus erythematosus (sle) pathology has long been associated with an increased epstein-barr virus (ebv) seropositivity, viremia and cross-reactive serum antibodies specific for both virus and self. it has therefore been postulated that ebv triggers sle immunopathology, although the mechanism remains elusive. here, we investigate whether frequent peaks of ebv viral load in sle patients are a consequence of dysfunctional anti-ebv cd8+ t cell responses. both inactive and active sle patient ... | 2011 | 22028659 |
| The lytic phase of epstein-barr virus requires a viral genome with 5-methylcytosine residues in CpG sites. | Epstein-Barr virus (EBV) is a human herpesvirus which has been studied intensively for its role in certain human tumors. It also serves as a model of herpesviral latency because it establishes an immediate, latent infection in human B cells. When EBV infects quiescent, primary B cells it induces their continuous proliferation to yield growth-transformed B-cell lines in vitro. The lytic or productive phase of EBV's life cycle is induced by the expression of the viral BZLF1 gene in latently infect ... | 2012 | 22031942 |
| Discrepancy in EBV-DNA load between peripheral blood and cerebrospinal fluid in a patient with isolated CNS post-transplant lymphoproliferative disorder. | Post-transplant lymphoproliferative disorder (PTLD) is a fatal complication of allogeneic hematopoietic stem cell transplantation (HSCT) that is caused by reactivation of Epstein-Barr virus (EBV). A successful approach, monitoring EBV-DNA load in peripheral blood (PB) accompanied by preemptive rituximab therapy, has recently been reported. Here, we describe a 29-year-old woman who developed isolated central nervous system (CNS) PTLD. She received HSCT against acute myelogenous leukemia from a re ... | 2011 | 22038015 |
| Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in malawian adults with bacterial meningitis. | Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis ... | 2012 | 22075766 |
| a critical role for stat3 transcription factor signaling in the development and maintenance of human t cell memory. | stat3 transcription factor signaling in specific t helper cell differentiation has been well described, although the broader roles for stat3 in lymphocyte memory are less clear. patients with autosomal-dominant hyper-ige syndrome (ad-hies) carry dominant-negative stat3 mutations and are susceptible to a variety of bacterial and fungal infections. we found that ad-hies patients have a cell-intrinsic defect in the number of central memory cd4(+) and cd8(+) t cells compared to healthy controls. nai ... | 2011 | 22118528 |
| oral hairy leukoplakia. | 2011 | 22128498 | |
| guillain-barre syndrome presenting with sensory disturbance following a herpes virus infection: a case report. | abstract: introduction: we present a case of an unusual clinical manifestation of guillain-barre syndrome following a pre-existing herpes virus infection. although there have been several reports describing the co-existence of herpes virus infection and guillain-barre syndrome, we undertook a more in-depth study of the cross-reactivity between herpes viruses and recommend a follow-up study based on serology tests. case presentation: a 39-year-old healthy caucasian man with guillain-barre syndro ... | 2011 | 22136568 |
| application of a novel highly sensitive activity-based probe for detection of cathepsin g. | cathepsins are crucial in antigen processing in the major histocompatibility complex class ii (mhc ii) pathway. within the proteolytic machinery, three classes of proteases (i.e., cysteine, aspartic, and serine proteases) are present in the endocytic compartments. the combined action of these proteases generates antigenic peptides from antigens, which are loaded to mhc ii molecules for cd4(+) t cell presentation. detection of active serine proteases in primary human antigen-presenting cells (apc ... | 2011 | 22178917 |
| Peripheral T-cell lymphoma arising from an intraglandular lymph node in the parotid gland: A case report and literature review. | T/NK-cell lymphoma of the salivary gland is rare. A 58-year-old man complained of a tumor mass in the left parotid gland region and he was diagnosed to have a left parotid tumor. The tumor was subsequently resected, revealing a diffuse growth pattern of medium to large sized atypical cells. The tumor was surrounded by fibrous connective tissue in the form of a capsule, and those were positive for CD3, CD4, CD5 and CD30, but negative for Bcl2, CD8, CD10, CD15, CD20, CD25, CD56, CD79a, CD246, EMA, ... | 2012 | 22192806 |
| Understanding TLR9 action in Epstein-Barr virus infection. | The Epstein-Barr virus (EBV) establishes persistent latent infection in peripheral blood memory B cells, may cause infectious mononucleosis, and is associated with cancers including endemic Burkitt's lymphoma (BL). Although latent EBV transforms B cells in vitro, additional factors including immunocompromised status or, as in endemic BL, a co-infection with the malaria parasite Plasmodium falciparum seem to be required for the development of EBV-associated cancers. Toll-like receptors (TLRs) lik ... | 2012 | 22201799 |
| posttransplant lymphoproliferative disorder presenting as multiple cystic lesions in a renal transplant recipient. | we report a case of a 67-year-old man who experienced allograft dysfunction following a renal transplantation from a donation after cardiac death. the postoperative course was initially complicated by episodes of e. coli urinary sepsis causing pyrexia and a raised creatinine level. ultrasound scanning 5 weeks posttransplant revealed mild hydronephrosis with several parenchymal cystic areas measuring up to 2 cm with appearances suggestive of fungal balls. aspirated fluid again grew escherichia co ... | 2012 | 22244123 |
| inhibition of the latent membrane protein-1 impairs the growth and tumorigenesis of an ebv-latency ii transformed t-cell. | the epstein-barr virus (ebv) is a common human herpes virus. its infection is associated with several human malignancies where it expresses a set of latent proteins among which is the latent membrane protein lmp1. lmp1 is able to transform numerous cell types and is considered the main oncogenic protein of ebv. the mechanism of action is based on mimicry to activated members of the tnf receptor superfamily, through its ability to bind similar adapters and to activate signaling pathways. we previ ... | 2012 | 22258264 |
| in vitro and in vivo antitumor effect of anti-cd33 chimeric receptor-expressing ebv-ctl against cd33 acute myeloid leukemia. | genetic engineering of t cells with chimeric t-cell receptors (cars) is an attractive strategy to treat malignancies. it extends the range of antigens for adoptive t-cell immunotherapy, and major mechanisms of tumor escape are bypassed. with this strategy we redirected immune responses towards the cd33 antigen to target acute myeloid leukemia. to improve in vivo t-cell persistence, we modified human epstein barr virus-(ebv-) specific cytotoxic t cells with an anti-cd33.car. genetically modified ... | 2012 | 22272203 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |