Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| aggregatibacter actinomycetemcomitans biofilm can be inactivated by methylene blue-mediated photodynamic therapy. | the purpose of this study was to evaluate the antibacterial effects of photodynamic action of methylene blue (mb) against aggregatibacter actinomycetemcomitans organized on biofilm. | 2015 | 25461964 |
| adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. | the aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (mox) in one-stage scaling and root planing (srp) in treating generalized aggressive periodontitis (gagp). | 2015 | 25469723 |
| integration of non-oral bacteria into in vitro oral biofilms. | biofilms are polymicrobial communities that grow on surfaces in nature. oral bacteria can spontaneously form biofilms on the surface of teeth, which may compromise the health of the teeth, or their surrounding (periodontal) tissues. while the oral bacteria exhibit high tropism for their specialized ecological niche, it is not clear if bacteria that are not part of the normal oral microbiota can efficiently colonize and grow within oral biofilms. by using an in vitro "supragingival" biofilm model ... | 2015 | 25483866 |
| subgingival microbial profiles of sudanese patients with aggressive periodontitis. | aggressive periodontitis (agp) is prevalent and shows a rapid course in african individuals. although a strong focus has been placed on aggregatibacter actinomycetemcomitans, new methods support the existence of a complex subgingival microflora in agp. the purpose of the present study was to map the subgingival microbiota as well as explore the presence of a. actinomycetemcomitans and the jp2 clone in a group of sudanese individuals with agp, using different analytical methods. | 2014 | 25487558 |
| synthesis of new antibacterial composite coating for titanium based on highly ordered nanoporous silica and silver nanoparticles. | infection is the most common factor that leads to dental titanium implant failure. antibacterial implant surfaces based on nano-scale modifications of the titanium appear as an attractive strategy for control of peri-implantitis. in the present work, the preparation and antibacterial properties of a novel composite coating for titanium based on nanoporous silica and silver nanoparticles are presented. starch-capped silver nanoparticles (agnps) were synthesized and then incorporated into sol-gel ... | 2014 | 25491813 |
| periodontal microbiology in latin america. | this review article describes the microbiota associated with periodontal disease in latin america. this vast territory includes 22 nations, which show great ethnic diversity, with large groups of white people, black people, mestizo people and native people. widespread poverty and limited access to education and health-care services, including periodontal care, are prominent predisposing factors for destructive periodontal disease in latin america. black people and mestizo people seem to have par ... | 2015 | 25494598 |
| clinical, microbial, and immune responses observed in patients with diabetes after treatment for gingivitis: a three-month randomized clinical trial. | although patients with diabetes are frequently affected by periodontitis, only a few investigations have focused on gingivitis in this at-risk population. this randomized placebo-controlled clinical trial compared the response to a gingivitis treatment protocol that combined mechanical procedures and daily use of an essential oil (eo) mouthrinse between patients with and without diabetes. | 2015 | 25494658 |
| aggregatibacter actinomycetemcomitans: virulence of its leukotoxin and association with aggressive periodontitis. | periodontitis is an infection-induced inflammatory disease that causes loss of the tooth supporting tissues. much focus has been put on comparison of the microbial biofilm in the healthy periodontium with the diseased one. the information arising from such studies is limited due to difficulties to compare the microbial composition in these two completely different ecological niches. a few longitudinal studies have contributed with information that makes it possible to predict which individuals w ... | 2014 | 25494963 |
| metabolic syndrome exacerbates inflammation and bone loss in periodontitis. | clinical studies have shown that metabolic syndrome (mets) is associated with increased risk of developing periodontitis. however, the underlying mechanisms remain largely unknown. since it is known that lipopolysaccharide (lps)-activated toll-like receptor 4 signaling pathways play a crucial role in periodontitis, we hypothesized that mets enhances lps-induced periodontal inflammation and alveolar bone loss. in this study, we induced mets in c57bl/6 mice by feeding them high-fat diet (hfd), and ... | 2015 | 25503900 |
| serum igg antibody levels to periodontal microbiota are associated with incident alzheimer disease. | periodontitis and alzheimer disease (ad) are associated with systemic inflammation. this research studied serum igg to periodontal microbiota as possible predictors of incident ad. | 2014 | 25522313 |
| microbiological effects of periodontal therapy plus azithromycin in patients with diabetes: results from a randomized clinical trial. | current evidence suggests that periodontal infection may aggravate diabetes control. the aim of this study was to determine the changes in the frequency with which porphyromonas gingivalis, tannerella forsythia, treponema denticola and aggregatibacter actinomycetemcomitans were detected in patients with diabetes with the use of non-surgical therapy plus azithromycin in a randomized clinical trial. one hundred and five (105) patients with diabetes and chronic periodontitis were randomly assigned ... | 2014 | 25523961 |
| distribution of 8 periodontal microorganisms in family members of chinese patients with aggressive periodontitis. | to date, no information on the distribution of periodontal microorganisms among family members of chinese patients with aggressive peridontitis (agp) is available. the aim of the present study was to investigate the probability of transmission of eight periodontal microorganisms between patients with aggressive periodontitis and their family members. | 2015 | 25526624 |
| the effect of il-4 gene polymorphisms on cytokine production in patients with chronic periodontitis and in healthy controls. | chronic periodontitis (cp) is an inflammatory disease of the teeth-supporting tissues in which genetic predisposition, dental plaque bacteria, and immune mechanisms all play important roles. the aim of this study was to evaluate the occurrence of il-4 gene polymorphisms in chronic periodontitis and to investigate the association between polymorphisms and cytokines production after bacterial stimulation. sixty-two subjects (47 cp patients and 15 healthy controls) with detected two polymorphisms i ... | 2014 | 25530681 |
| attenuation of inflammatory response by 25- hydroxyvitamin d3-loaded polylactic acid microspheres in treatment of periodontitis in diabetic rats. | to investigate the inhibitory effects of 25-hydroxyvitamin d3 (25(oh)d3)-loaded polylactic acid (pla) microspheres on inflammatory response in diabetic periodontitis. | 2014 | 25531016 |
| microbial leakage at the implant-abutment connection due to implant insertion maneuvers: cross-sectional study 5 years postloading in healthy patients. | the aim of this study was to test if stress on the prosthetic connection during insertion maneuvers can induce micro-warping at the implant connection. from september 2011 to july 2013, patients with implants loaded for at least 5 years that were placed with 2 different insertion implant mounters-mp (conventional) and me (mountless)-were selected from all of those who had received dental implant therapy in the past and were attending routine check-up or spontaneous visits during the study period ... | 2015 | 25536224 |
| effects of adjunctive daily phototherapy on chronic periodontitis: a randomized single-blind controlled trial. | the purpose of this randomized single-blind controlled trial was to elucidate the clinical and antimicrobial effects of daily phototherapy (pt) as an adjunct to scaling and root planing (srp) in patients with chronic periodontitis. | 2014 | 25568808 |
| antibacterial effect of an herbal product persica on porphyromonas gingivalis and aggregatibacter actinomycetemcomitans: an in-vitro study. | the plant salvadora persica is used for oral hygiene in many parts of the world. it has been suggested that it has antibacterial properties, in addition to its ability to mechanically remove plaques. the aim of this study was to assess the antimicrobial activity of the herbal product persica containing salvadora persica against periodontopathogens porphyromonas gingivalis and aggregatibacter actinomycetemcomitans in vitro. | 2014 | 25584059 |
| molecular docking study for inhibitors of aggregatibacter actinomycetamcomitans toxins in treatment of aggressive perioodontitis. | periodontitis is a chronic inflammatory disease of the periodontal tissues causing periodontal attachment loss and destruction of the alveolar bone which leads to mobility and loss of teeth. aggregatibacter actinomycetemcomitans (aa) is a gram negative, capnophilic, coccobacillus that plays an important role in aggressive periodontitis. aa produces a variety of virulence factors that facilitate the colonization, invasion and destruction of the periodontal tissues. leukotoxin and cytolethal diste ... | 2014 | 25584316 |
| selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation. | periodontitis (pd) is a chronic infectious disease mediated by bacteria in the oral cavity. (poly)phenols (pps), ubiquitous in plant foods, possess antimicrobial activities and may be useful in the prevention and management of periodontitis. the objective of this study was to test the antibacterial effects of selected pps on periodontal pathogens, on both planktonic and biofilm modes of growth. selected pps (n = 48) were screened against streptococcus mitis (s. mitis), aggregatibacter actinomyce ... | 2015 | 25585200 |
| microleakage of bacteria in different implant-abutment assemblies: an in vitro study. | the aim of the present in vitro study was to evaluate the leakage observed for 2 different microbial species at the level of the implant-abutment (i-a) interface, and the marginal fit and size of microgap at the i-a interface in 2 different implant connections. | 2015 | 25589158 |
| association between periodontal condition and subgingival microbiota in women during pregnancy: a longitudinal study. | in this study, the gingival conditions and the quantitative detection for aggregatibacter actinomycetemcomitans, fusobacterium nucleatum, porphyromonas gingivalis and prevotella intermedia in pregnant women were determined. | 2014 | 25591021 |
| anti-inflammatory, antioxidant and antimicrobial effects of artemisinin extracts from artemisia annua l. | the anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of artemisia annua l. were evaluated. all 4 artemisinin-containing extracts had anti-inflammatory effects. of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (no), prostaglandin e2 (pge2), and proinflammatory cytokine (il-1β , il-6, and il-10) production. antioxidant activity evaluations revealed that t ... | 2015 | 25605993 |
| assessment of porphyromonas gingivalis and aggregatibacter actinomycetemcomitans in down's syndrome subjects and systemically healthy subjects: a comparative clinical trial. | to compare and quantify the presence of periodontal pathogens aggregatibacter actinomycetemcomitans (aac) and porphyromonas gingivalis (pg) in down's syndrome (ds) and systemically healthy subjects with periodontitis and gingivitis. | 2017 | 25624629 |
| periodontopathogen levels following the use of an er:yag laser in the treatment of chronic periodontitis. | inflammatory periodontal diseases are initiated by microbial biofilms. the reduction of the biofilm is important in the management of the disease. this study compares periodontopathogen levels following the treatment of chronic periodontitis using er:yag laser debridement and mechanical scaling and root planing. | 2015 | 25630495 |
| short-term effect of removal of fixed orthodontic appliances on gingival health and subgingival microbiota: a prospective cohort study. | the aim of this prospective longitudinal study was to assess and compare the microbiological and clinical parameters of patients wearing a fixed orthodontic appliance, as opposed to 10 days after the bracket had been removed following treatment. | 2015 | 25631494 |
| aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the nlrp3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines. | the cytolethal distending toxin (cdt) is produced from a number of bacteria capable of causing infection and inflammatory disease. our previous studies with actinobacillus actinomycetemcomitans cdt demonstrate not only that the active toxin subunit functions as a phosphatidylinositol-3,4,5-triphosphate (pip3) phosphatase but also that macrophages exposed to the toxin were stimulated to produce proinflammatory cytokines. we now demonstrate that the cdt-induced proinflammatory response involves th ... | 2015 | 25644004 |
| clinical and microbiological effects of levofloxacin in the treatment of aggregatibacter actinomycetemcomitans-associated periodontitis: a randomized placebo-controlled clinical trial. | to evaluate the clinical and microbiological effects of systemic levofloxacin (lfx) in subjects with aggregatibacter actinomycetemcomitans-associated chronic periodontitis (aa-acp). | 2014 | 25654959 |
| bactericidal activity and mechanism of photoirradiated polyphenols against gram-positive and -negative bacteria. | the bactericidal effect of various types of photoirradiated polyphenols against gram-positive and -negative bacteria was evaluated in relation to the mode of action. gram-positive bacteria (enterococcus faecalis, staphylococcus aureus, and streptococcus mutans) and gram-negative bacteria (aggregatibacter actinomycetemcomitans, escherichia coli, and pseudomonas aeruginosa) suspended in a 1 mg/ml polyphenol aqueous solution (caffeic acid, gallic acid, chlorogenic acid, epigallocatechin, epigalloca ... | 2015 | 25660393 |
| [antibacterial activity of synthetic antimicrobial decapeptide against oral bacteria]. | this study aims to evaluate the antimicrobial activity of decapeptide, a novel antimicrobial peptide, against several major cariogenic and periodontopathogenic bacteria in vitro. methods in this study, we investigated the antimicrobial activity of decapeptide against streptococcus mutans (s. mutans), streptococcus sobrinus, lactobacillus acidophilus, streptococcus sanguis, streptococcus gordonii, actinomyces viscosus, actinomyces naeslundii, porphyromonas gingivalis, prevotella intermedia, fusob ... | 2014 | 25665430 |
| anaerobic culture to detect periodontal and caries pathogens. | anaerobic culture has been critical in our understanding of the oral microbiotas. | 2014 | 25678835 |
| inter- and intra-test agreement of three commercially available molecular diagnostic tests for the identification of periodontal pathogens. | the aim of the study was to compare the agreement and reproducibility of three test kits (iai pado test 4⋅5®, micro-ident®, and carpegen® perio diagnostik) regarding the detection of porphyromonas gingivalis, tannerella forsythia, treponema denticola, and aggregatibacter actinomycetemcomitans. | 2015 | 25680706 |
| alteration in abundance of specific membrane proteins of aggregatibacter actinomycetemcomitans is attributed to deletion of the inner membrane protein morc. | aggregatibacter actinomycetemcomitans is an important pathogen in the etiology of human periodontal and systemic diseases. inactivation of the gene coding for the inner membrane protein, morphogenesis protein c (morc), results in pleotropic effects pertaining to the membrane structure and function of this bacterium. the role of this protein in membrane biogenesis is unknown. to begin to understand the role of this conserved protein, stable isotope dimethyl labeling in conjunction with ms was use ... | 2015 | 25684173 |
| cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients. | lysine-specific gingipain (kgp) is a virulence factor secreted from porphyromonas gingivalis (p. gingivalis), a major etiological bacterium of periodontal disease. keratin intermediate filaments maintain the structural integrity of gingival epithelial cells, but are targeted by kgp to produce a novel cytokeratin 6 fragment (k6f). we investigated the release of k6f and its induction of cytokine secretion. | 2015 | 25688865 |
| role of exopolysaccharide in aggregatibacter actinomycetemcomitans-induced bone resorption in a rat model for periodontal disease. | aggregatibacter actinomycetemcomitans a causative agent of periodontal disease in humans, forms biofilm on biotic and abiotic surfaces. a. actinomycetemcomitans biofilm is heterogeneous in nature and is composed of proteins, extracellular dna and exopolysaccharide. to explore the role played by the exopolysaccharide in the colonization and disease progression, we employed genetic reduction approach using our rat model of a. actinomycetemcomitans-induced periodontitis. to this end, a genetically ... | 2015 | 25706999 |
| comparison of serum amyloid a protein and c-reactive protein levels as inflammatory markers in periodontitis. | the purpose of this study was to compare serum amyloid a (saa) protein levels with high-sensitive c-reactive protein (hs-crp) levels as markers of systemic inflammation in patients with chronic periodontitis. the association of serum titers of antibodies to periodontal microbiota and saa/hs-crp levels in periodontitis patients was also studied. | 2015 | 25722922 |
| aggregatibacter actinomycetemcomitans induces th17 cells in atherosclerotic lesions. | th17 cells have been linked to the pathogenesis of several chronic inflammatory and autoimmune diseases. however, the role of th17 cells and il-17 in atherosclerosis remains poorly understood. we previously reported that aggregatibacter actinomycetemcomitans (aa) bacteremia accelerated atherosclerosis accompanied by inflammation in apolipoprotein e-deficient spontaneously hyperlipidemic (apoe(shl)) mice. in this study, we investigated whether aa promotes the th17 inducing pathway in aa-challenge ... | 2015 | 25743474 |
| protective effects of the angiotensin type 1 receptor antagonist losartan in infection-induced and arthritis-associated alveolar bone loss. | the angiotensin type 1 (at1) receptor has been implicated in the pathogenesis of inflammatory bone disorders. this study aimed to investigate the effect of an at1 receptor antagonist in infection-induced and arthritis-associated alveolar bone loss in mice. | 2015 | 25753377 |
| antibacterial photodynamic treatment of periodontopathogenic bacteria with indocyanine green and near-infrared laser light enhanced by trolox(tm). | it has been shown that certain vitamins can significantly enhance the effect of photodynamic anti-tumor therapy. unfortunately, there is no sufficient information available about the impact of those antioxidants on antimicrobial photodynamic therapy (apdt). the present study is aimed at investigating the antimicrobial effect of the dye indocyanine green (icg) in the presence of trolox(tm) , a vitamin e analogue, upon irradiation with near-infrared (nir) laser light (808 nm) on the gramnegative p ... | 2015 | 25753989 |
| quantitative proteomics reveal distinct protein regulations caused by aggregatibacter actinomycetemcomitans within subgingival biofilms. | periodontitis is an infectious disease that causes the inflammatory destruction of the tooth-supporting (periodontal) tissues, caused by polymicrobial biofilm communities growing on the tooth surface. aggressive periodontitis is strongly associated with the presence of aggregatibacter actinomycetemcomitans in the subgingival biofilms. nevertheless, whether and how a. actinomycetemcomitans orchestrates molecular changes within the biofilm is unclear. the aim of this work was to decipher the inter ... | 2015 | 25756960 |
| a. actinomycetemcomitans profile and red complex bacterial species of an afro-brazilian community: a comparative study. | the primary aim of this cross-sectional study was to compare the levels of red complex bacteria between afro-brazilian and non afro-brazilian cohort. the secondary aim was to compare the distribution of both aggregatibacter actinomycetemcomitans serotype b and its jp2 strains among participants who harboured this bacterial species. | 2015 | 25757149 |
| aggregatibacter actinomycetemcomitans invasion induces interleukin-1β production through reactive oxygen species and cathepsin b. | interleukin-1 (il-1) cytokines, il-1α, il-1β, and il-18 play a crucial role in inflammatory responses in a variety of diseases including periodontitis. in this study, the periodontopathic bacterial pathogen, aggregatibacter actinomycetemcomitans, induced cell death and cytokine release in macrophages. cell viability was reduced by a. actinomycetemcomitans invasion using (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide assay. the production of il-1β in a. actinomycetemcomitans-inva ... | 2015 | 25789553 |
| green tea polyphenol epigallocatechin-3-gallate and cranberry proanthocyanidins act in synergy with cathelicidin (ll-37) to reduce the lps-induced inflammatory response in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts. | the human antimicrobial peptide cathelicidin (ll-37) possesses anti-inflammatory properties that may contribute to attenuating the inflammatory process associated with chronic periodontitis. plant polyphenols, including those from cranberry and green tea, have been reported to reduce inflammatory cytokine secretion by host cells. in the present study, we hypothesized that a-type cranberry proanthocyanidins (ac-pacs) and green tea epigallocatechin-3-gallate (egcg) act in synergy with ll-37 to red ... | 2015 | 25791329 |
| intracranial bacterial infections of oral origin. | brain abscesses are rare but potentially deadly complications of odontogenic infections. this phenomenon has been described mainly in the form of case reports, as large-scale studies are difficult to perform. we compiled a total of 60 previously published cases of such a complication to investigate the predisposing factors, microbiology, and clinical outcomes of intracranial abscesses of odontogenic origin. a systematic review of the literature using the pubmed database was performed. men accoun ... | 2015 | 25800939 |
| antimicrobial photodynamic effect to treat residual pockets in periodontal patients: a randomized controlled clinical trial. | a randomized controlled clinical trial was designed to evaluate the efficacy of the photodynamic therapy (pdt) in the treatment of residual pockets of chronic periodontitis patients. | 2015 | 25808980 |
| periodontal therapy effects on nitrite related to oral bacteria: a 6-month randomized clinical trial. | nitrite is a biologic factor relevant to oral and systemic homeostasis. through an oral bacteria reduction process, it was suggested that periodontal therapy and chlorhexidine (chx) rinse could affect nitrite levels, leading to negative effects, such as an increase in blood pressure. this 6-month randomized clinical trial evaluated the effects of periodontal therapeutic protocols on salivary nitrite and its relation to subgingival bacteria. | 2015 | 25811847 |
| association between aggregatibacter actinomycetemcomitans and porphyromonas gingivalis in subgingival plaque and clinical parameters, in argentine patients with aggressive periodontitis. | aggregatibacter actinomycetemcomitans (aa) and porphyromonas gingivalis (pg) have been associated with aggressive (agp) and chronic periodontitis. | 2015 | 25812474 |
| t-lymphocyte phenotype and function triggered by aggregatibacter actinomycetemcomitans is serotype-dependent. | based on lipopolysaccharide (lps) antigenicity, different aggregatibacter actinomycetemcomitans serotypes have been described. serotype b strains have demonstrated a stronger capacity to trigger cytokine production on dendritic cells (dcs). as dcs regulate the development of t-lymphocyte lineages, the objective of this investigation was to study the response of t lymphocytes after being stimulated with autologous dcs primed with different bacterial strains belonging to the most prevalent serotyp ... | 2015 | 25824938 |
| enterococcus faecalis lipoteichoic acid suppresses aggregatibacter actinomycetemcomitans lipopolysaccharide-induced il-8 expression in human periodontal ligament cells. | periodontitis is caused by multi-bacterial infection and aggregatibacter actinomycetemcomitans and enterococcus faecalis are closely associated with inflammatory periodontal diseases. although lipopolysaccharide (lps) of a. actinomycetemcomitans (aa.lps) and lipoteichoic acid of e. faecalis (ef.lta) are considered to be major virulence factors evoking inflammatory responses, their combinatorial effect on the induction of chemokines has not been investigated. in this study, we investigated the in ... | 2015 | 25840438 |
| occurrence of periodontal pathogens in ethnic groups from a native brazilian reservation. | the present study was designed to evaluate the occurrence of periodontal pathogens in the subgingival biofilm of 100 native brazilians living at the umutina indian reservation, mato grosso state, brazil. | 2015 | 25847068 |
| lfa-1-targeting leukotoxin (ltxa; leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and fas to kill malignant lymphocytes. | leukotoxin (ltxa) is a protein secreted from the oral bacterium aggregatibacter actinomycetemcomitans. ltxa binds to the β2 integrin lymphocyte-associated function antigen-1 (lfa-1) on human white blood cells (wbcs), resulting in cell death. ltxa is currently under investigation as a novel therapy (leukothera(®)) for treating hematologic malignancies and autoimmune diseases. we show here that ltxa has potent in vivo anti-lymphoma activity in mice. ltxa caused complete regression of b-cell tumors ... | 2015 | 25850729 |
| antimicrobial activity of chemokine cxcl10 for dermal and oral microorganisms. | cxcl10 (ip-10) is a small 10 kda chemokine with antimicrobial activity. it is induced by ifn-γ, chemoattracts mononuclear cells, and promotes adhesion of t cells. recently, we detected cxcl10 on the surface of the skin and in the oral cavity. in the current study, we used broth microdilution and radial diffusion assays to show that cxcl10 inhibits the growth of escherichia coli, staphylococcus aureus, corynebacterium jeikeium, corynebacterium striatum, and candida albicans hmv4c, but not coryneb ... | 2014 | 25859394 |
| non-linear association of periodontal pathogen antibodies with mortality. | periodontal pathogens are associated with predisposition to chronic diseases and death. antibody levels against them reflect flora burden, although high levels might indicate a protective response. we studied all-cause and cause specific mortality in relation to antibody levels in a representative us sample. | 2015 | 25863738 |
| laser supported reduction of specific microorganisms in the periodontal pocket with the aid of an er,cr:ysgg laser: a pilot study. | the aim of this study was to evaluate the effectiveness of a radial firing tip of an er,cr:ysgg laser as an adjunct to a nonsurgical periodontal treatment. | 2015 | 25879057 |
| detection of a 640-bp deletion in the aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of ethiopian origin. | the expression of the leukotoxin of aggregatibacter actinomycetemcomitans is regulated by the leukotoxin promoter. a 530-bp deletion or an 886-bp insertion sequence (is) element in this region has earlier been described in highly leukotoxic isolates. here, we report on highly leukotoxic isolate with a 640-bp deletion, which was detected in an adolescent of ethiopian origin. | 2015 | 25881573 |
| bacterial profile of aggressive periodontitis in morocco: a cross-sectional study. | aggressive periodontitis (agp) is one of the most severe forms of periodontal diseases. in morocco, aggregatibacter actinomycetemcomitans has been strongly associated with agp, however limited knowledge is available about the implication of other periodontal pathogens in this entity. therefore, the main aim of this study was to evaluate the composition of the subgingival microbiota in moroccan patients with agp. | 2015 | 25888404 |
| periodontal inflammation and alveolar bone loss induced by aggregatibacter actinomycetemcomitans is attenuated in sphingosine kinase 1-deficient mice. | sphingosine-1-phosphate (s1p) is a bioactive sphingolipid, which is generated by activation of sphingosine kinase (sk) 1 and/or 2 in most mammalian cells with various stimuli, including the oral pathogen aggregatibacter actinomycetemcomitans. s1p signaling has been shown to regulate the migration of monocytes and macrophages (osteoclast precursors) from the circulation to bone tissues and affect bone homeostasis. we aimed to determine the effects of sk1 deficiency on s1p generation, proinflammat ... | 2016 | 25900155 |
| full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: a pilot study. | the evidence of effectiveness of metronidazole (mtz) as an adjunct therapy to periodontal procedure in the treatment of patients with chronic periodontitis is not conclusive. the aim of this study was to compare the effect of mtz (delivered locally as a gel or systemically as a tablet) as an adjunctive therapy with full mouth periodontal debridement (1 h of ultrasonic calculus/plaque removal) in smokers with chronic periodontitis. | 2016 | 25900347 |
| influence of complement on neutrophil extracellular trap release induced by bacteria. | neutrophil extracellular trap (net) release has generally been studied in the absence of serum, or at low concentrations of untreated or heat-inactivated serum. the influence of serum complement on net release therefore remains unclear. we examined the dna release induced by staphylococcus aureus and three oral bacteria: actinomyces viscosus, aggregatibacter actinomycetemcomitans and fusobacterium nucleatum subsp. vincettii. | 2016 | 25900429 |
| synthesis of new carolacton derivatives and their activity against biofilms of oral bacteria. | carolacton, a secondary metabolite isolated from the extracts of sorangium cellulosum, causes membrane damage and cell death in biofilms of the caries- and endocarditis-associated bacterium streptococcus mutans. here, we report the total synthesis of several derivatives of carolacton. all new structural modifications introduced abolished its biological activity, including subtle ones, such as inversion of configuration at c9. however, a bicyclic bislactone derivative as well as the methyl ester ... | 2015 | 25902328 |
| aggregatibacter actinomycetemcomitans qsebc is activated by catecholamines and iron and regulates genes encoding proteins associated with anaerobic respiration and metabolism. | aggregatibacter actinomycetemcomitans qsebc regulates its own expression and is essential for biofilm growth and virulence. however, the signal that activates the qsec sensor has not been identified and the qsebc regulon has not been defined. in this study, we show that qsec is activated by catecholamine hormones and iron but not by either component alone. activation of qsec requires an eyrdd motif in the periplasmic domain of the sensor and site-specific mutations in eyrdd or the deletion of th ... | 2015 | 25923132 |
| quantitation of biofilm and planktonic life forms of coexisting periodontal species. | complexity of oral polymicrobial communities has prompted a need for developing in vitro models to study behavior of coexisting bacteria. little knowledge is available of in vitro co-growth of several periodontitis-associated species without early colonizers of dental plaque. | 2015 | 25926392 |
| the effect of photodynamic therapy on aggregatibacter actinomycetemcomitans attached to surface-modified titanium. | the purpose of this study was to evaluate the effect of photodynamic therapy (pdt) using erythrosine and a green light emitting diode (led) light source on biofilms of aggregatibacter actinomycetemcomitans attached to resorbable blasted media (rbm) and sandblasted, large-grit, acid-etched (sla) titanium surfaces in vitro. | 2015 | 25932337 |
| periodontitis associated with plasminogen deficiency: a case report. | plasminogen deficiency is a rare autosomal recessive disease, which is associated with aggressive periodontitis and gingival enlargement. previously described treatments of plasminogen deficiency associated periodontitis have shown limited success. this is the first case report indicating a successful therapy approach consisting of a non-surgical supra- and subgingival debridement in combination with an adjunctive systemic antibiotic therapy and a strict supportive periodontal regimen over an ob ... | 2015 | 25971786 |
| interleukin-6 and microrna profiles induced by oral bacteria in human atheroma derived and healthy smooth muscle cells. | atherosclerosis is an inflammatory disease with possible contributions from bacterial antigens. we aimed to investigate the role of oral bacteria as inducers of inflammatory cascades in smooth muscle cells from carotid endarterectomy patients (athsmcs) and healthy controls (hsmcs). | 2015 | 25984438 |
| lipopolysaccharide of aggregatibacter actinomycetemcomitans induces the expression of chemokines mcp-1, mip-1α, and ip-10 via similar but distinct signaling pathways in murine macrophages. | aggregatibacter actinomycetemcomitans is a gram-negative bacterium frequently isolated from lesions of patients with localized aggressive periodontitis. lipopolysaccharide (lps), a major cell wall component of gram-negative bacteria, stimulates innate immune cells via toll-like receptor 4 (tlr4) to initiate inflammatory responses. in this study, we purified lps from a. actinomycetemcomitans (aalps) and investigated its ability to induce the expression of chemokines, which play an important role ... | 2015 | 26003840 |
| essential oil from berries of lebanese juniperus excelsa m. bieb displays similar antibacterial activity to chlorhexidine but higher cytocompatibility with human oral primary cells. | chlorhexidine (chx), one of the most effective drugs administered for periodontal treatment, presents collateral effects including toxicity when used for prolonged periods; here, we have evaluated the bactericidal potency and the cytocompatibility of juniperus excelsa m. bieb essential oil (eo) in comparison with 0.05% chx. the eo was extracted from berries by hydrodistillation and components identified by gas chromatography and mass spectrometry. bacterial inhibition halo analysis, quantitative ... | 2015 | 26007187 |
| antimicrobial effects of citrus sinensis peel extracts against periodontopathic bacteria: an in vitro study. | use of plant extracts and phytochemicals with known antimicrobial properties may have great significance in therapeutic treatments. | 2015 | 26024407 |
| coaggregation and biofilm growth of granulicatella spp. with fusobacterium nucleatum and aggregatibacter actinomycetemcomitans. | members of fastidious granulicatella and aggregatibacter genera belong to normal oral flora bacteria that can cause serious infections, such as infective endocarditis. aggregatibacter actinomycetemcomitans has long been implicated in aggressive periodontitis, whereas dna-based methods only recently showed an association between granulicatella spp. and dental diseases. as bacterial coaggregation is a key phenomenon in the development of oral and nonoral multispecies bacterial communities it would ... | 2015 | 26025449 |
| evaluation of a hydrophobic gel adhering to the gingiva in comparison with a standard water-soluble 1% chlorhexidine gel after scaling and root planing in patients with moderate chronic periodontitis. a randomized clinical trial. | to evaluate the clinical, microbiological and enzymatic activity of a hydrophobic chlorhexidine-based gingiva-adhering gel containing herbal ingredients, compared with a commercially available 1% chlorhexidine water-soluble gel, during non-surgical therapy of moderate chronic periodontitis. | 2017 | 26053503 |
| alcohol consumption and periodontitis: quantification of periodontal pathogens and cytokines. | there are few studies on periodontal status related to microbiologic and immunologic profiles among individuals not or occasionally using alcohol and those with alcohol dependence. the aim of this study is to determine the effect of alcohol consumption on the levels of subgingival periodontal pathogens and proinflammatory cytokines (interleukin [il]-1β and tumor necrosis factor [tnf]-α) in the gingival fluid among individuals with and without periodontitis. | 2015 | 26062839 |
| kinetic-dependent killing of oral pathogens with nitric oxide. | nitric oxide (no)-releasing silica nanoparticles were synthesized via the co-condensation of tetramethyl orthosilicate with aminosilanes and subsequent conversion of secondary amines to n-diazeniumdiolate no donors. a series of ~150 nm no-releasing particles with different no totals and release kinetics (i.e., half-lives) were achieved by altering both the identity and mol% composition of the aminosilane precursors. independent of identical 2 h no-release totals, enhanced antibacterial action wa ... | 2015 | 26078424 |
| periodontal bacteria and prediabetes prevalence in origins: the oral infections, glucose intolerance, and insulin resistance study. | periodontitis and type 2 diabetes mellitus are known to be associated. the relationship between periodontal microbiota and early diabetes risk has not been studied. we investigated the association between periodontal bacteria and prediabetes prevalence among diabetes-free adults. origins (the oral infections, glucose intolerance and insulin resistance study) cross sectionally enrolled 300 diabetes-free adults aged 20 to 55 y (mean ± sd, 34 ± 10 y; 77% female). prediabetes was defined as follows: ... | 2015 | 26082387 |
| prevalence of eight putative periodontal pathogens in atherosclerotic plaque of coronary artery disease patients and comparing them with noncardiac subjects: a case-control study. | the study was aimed to assess the prevalence of periodontal pathogens namely tannerella forsythia (t.f), campylobacter rectus (c.r), eikenella corrodens (e.c), porphyromonas gingivalis (p.g), treponema denticola (t.d), prevotella nigrescens (p.n) ,aggregatibacter actinomycetemcomitans (a.a), p.g (fi ma gene) and prevotella intermedia (p.i), in the subgingival and the atheromatous plaque of patients with coronary artery disease (cad), and comparing them with the noncardiac subjects thereby indica ... | 2017 | 26096116 |
| determination of antibacterial activity of green coffee bean extract on periodontogenic bacteria like porphyromonas gingivalis, prevotella intermedia, fusobacterium nucleatum and aggregatibacter actinomycetemcomitans: an in vitro study. | the aim of this study was to evaluate the antibacterial activity of pure green coffee bean extract on periodonto pathogenic bacteria porphyromonas gingivalis (pg), prevotella intermedia (pi), fusobacterium nucleatum (fn) and aggregatibacter actinomycetemcomitans (aa). | 2017 | 26097349 |
| periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased dominican adults. | the objective of this study was to compare the periodontopathogen prevalence and tetracycline resistance genes in dominican patients with different periodontal conditions. | 2015 | 26121972 |
| fty720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by aggregatibacter actinomycetemcomitans. | periodontitis is a bacteria-driven inflammatory bone loss disease. previous studies showed that the oral pathogen aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) stimulated the generation of sphingosine 1 phosphate (s1p). in addition, s1p signaling regulated the migration of osteoclast precursors and affected osteoclastogenesis. furthermore, treatment with fty720 (also called fingolimod, a modulator of multiple s1p receptors) alleviated osteoporosis and suppressed arthritis in a ... | 2015 | 26138336 |
| coinfection with fusobacterium nucleatum can enhance the attachment and invasion of porphyromonas gingivalis or aggregatibacter actinomycetemcomitans to human gingival epithelial cells. | this study was conducted to investigate effects of coinfection of porphyromonas gingivalis (p. gingivalis) or aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) with fusobacterium nucleatum (f. nucleatum) on their adhering and invasive capacity to human gingival epithelial cells as well as the expression of interleukin-8 (il-8) and human beta-defensin-2 (hbd-2) in human gingival epithelial cells. | 2015 | 26143497 |
| determination of porphyrins in oral bacteria by liquid chromatography electrospray ionization tandem mass spectrometry. | biofilms in the oral cavity can be visualized by fluorescence and a common assumption is that the endogenously produced porphyrins in certain bacteria give rise to this fluorescence. porphyrin content in oral bacteria has been sparingly investigated, and non-selective detection techniques such as utilizing the soret fluorescence band of porphyrins are often used. in the present study, a quantitative and selective method for the determination of porphyrins in oral bacteria has been developed and ... | 2015 | 26168965 |
| essential oils from ugandan aromatic medicinal plants: chemical composition and growth inhibitory effects on oral pathogens. | the study assessed the growth inhibitory effects of essential oils extracted from ten ugandan medicinal plants (bidens pilosa, helichrysum odoratissimum, vernonia amygdalina, hoslundia opposita, ocimum gratissimum, cymbopogon citratus, cymbopogon nardus, teclea nobilis, zanthoxylum chalybeum, and lantana trifolia) used traditionally in the management of oral diseases against oral pathogens. chemical compositions of the oils were explored by gc-ms. inhibitory effects of the oils were assessed on ... | 2015 | 26170872 |
| serotype b of aggregatibacter actinomycetemcomitans increases osteoclast and memory t-lymphocyte activation. | during periodontitis, alveolar bone resorption is associated with activation of t helper type 17 (th17) lymphocytes and receptor activator of nuclear factor-κb ligand (rankl) -induced osteoclasts. we previously reported that serotype b of aggregatibacter actinomycetemcomitans has a higher capacity to trigger th17-type differentiation and function in activated t lymphocytes and its lipopolysaccharide is a more potent immunogen compared with the other serotypes. this study aimed to investigate whe ... | 2016 | 26172400 |
| antimicrobial activity of polyhexamethylene guanidine phosphate in comparison to chlorhexidine using the quantitative suspension method. | polyhexamethylene guanidine phosphate (phmg-p) belongs to the polymeric guanidine family of biocides and contains a phosphate group, which may confer better solubility, a detoxifying effect and may change the kinetics and dynamics of phmg-p interactions with microorganisms. limited data regarding phmg-p activity against periodontopathogenic and cariogenic microorganisms necessitates studies in this area. aim is to evaluate polyhexamethylene guanidine phosphate antimicrobial activity in compariso ... | 2015 | 26182984 |
| detection of subgingival periodontal pathogens--comparison of two sampling strategies. | the aim of the study is to compare detection frequency of periodontal pathogens in patients with aggressive/severe chronic periodontitis using pooled plaque samples from the deepest pockets per quadrant/per sextant. | 2016 | 26193958 |
| association of porphyromonas gingivalis with high levels of stress-induced hormone cortisol in chronic periodontitis patients. | the aim of the present study was to evaluate the association between the occurrence of periodontopathogens with cortisol levels in chronic periodontitis patients. | 2016 | 26194628 |
| aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis. | aggregatibacter actinomycetemcomitans is a perio-pathogenic bacteria that has long been associated with localized aggressive periodontitis. the mechanisms of its pathogenicity have been studied in humans and preclinical experimental models. although different serotypes of a. actinomycetemcomitans have differential virulence factor expression, a. actinomycetemcomitans cytolethal distending toxin (cdt), leukotoxin, and lipopolysaccharide (lps) have been most extensively studied in the context of m ... | 2016 | 26197893 |
| the conserved carboxyl domain of morc, an inner membrane protein of aggregatibacter actinomycetemcomitans, is essential for membrane function. | morphogenesis protein c (morc) of aggregatibacter actinomycetemcomitans is important for maintaining the membrane morphology and integrity of the cell envelope of this oral pathogen. the morc sequence and operon organization were found to be conserved in gammaproteobacteria, based on a bioinformatic analysis of 435 sequences from representative organisms. functional conservation of morc was investigated using an a. actinomycetemcomitans morc mutant as a model system to express morc homologs from ... | 2015 | 26205976 |
| colonization and persistence of labeled and "foreign" strains of aggregatibacter actinomycetemcomitans inoculated into the mouths of rhesus monkeys. | aggregatibacter actinomycetemcomitans (aa) is a pathobiont and part of a consortium of bacteria that can lead to periodontitis in humans. our aim was to develop a model for oral inoculation of labeled aa into a suitable host in order to study aa traits and ecological factors that either enhance or repress its persistence. primate species were screened for aa to select a host for colonization studies. macaca mulatta (rhesus/rh) was selected. rh aa strains were isolated, subjected to sequencing an ... | 2015 | 26213715 |
| gingival mesenchymal stem cell (gmsc) delivery system based on rgd-coupled alginate hydrogel with antimicrobial properties: a novel treatment modality for peri-implantitis. | peri-implantitis is one of the most common inflammatory complications in dental implantology. similar to periodontitis, in peri-implantitis, destructive inflammatory changes take place in the tissues surrounding a dental implant. bacterial flora at the failing implant sites resemble the pathogens in periodontal disease and consist of gram-negative anaerobic bacteria including aggregatibacter actinomycetemcomitans (aa). here we demonstrate the effectiveness of a silver lactate (sl)-containing rgd ... | 2016 | 26216081 |
| the aggregatibacter actinomycetemcomitans cytolethal distending toxin active subunit cdtb contains a cholesterol recognition sequence required for toxin binding and subunit internalization. | induction of cell cycle arrest in lymphocytes following exposure to the aggregatibacter actinomycetemcomitans cytolethal distending toxin (cdt) is dependent upon the integrity of lipid membrane microdomains. moreover, we have previously demonstrated that the association of cdt with target cells involves the cdtc subunit which binds to cholesterol via a cholesterol recognition amino acid consensus sequence (crac site). in this study, we demonstrate that the active cdt subunit, cdtb, also is capab ... | 2015 | 26216427 |
| combined orthodontic and periodontic treatment in a child with papillon lefèvre syndrome. | a 9-year-old girl with papillon-lefèvre syndrome (pls) was treated orthodontically 24 months after the start of mechanical and antibiotic therapy in adjunct with periodontal treatment every 6 weeks. after achieving stable periodontal conditions, orthodontic treatment was commenced to correct the teeth position, facial profile, and maxillary protraction. following the combination therapy and a failure to detect actinobacillus actinomycetemcomitans from any site in the oral cavity, orthodontic tre ... | 2015 | 26219452 |
| host response mechanisms in periodontal diseases. | periodontal diseases usually refer to common inflammatory disorders known as gingivitis and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm, including porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, tannerella forsythia and treponema denticola that trigger innate, inflammatory, and adaptive immune responses. these processes result in the destruction of the tissues surrounding and supporting the teeth, and eventually in tissue, bone and final ... | 2015 | 26221929 |
| transcriptome profiling of wild-type and pga-knockout mutant strains reveal the role of exopolysaccharide in aggregatibacter actinomycetemcomitans. | exopolysaccharides have a diverse set of functions in most bacteria including a mechanistic role in protecting bacteria against environmental stresses. among the many functions attributed to the exopolysaccharides, biofilm formation, antibiotic resistance, immune evasion and colonization have been studied most extensively. the exopolysaccharide produced by many gram positive as well as gram negative bacteria including the oral pathogen aggregatibacter actinomycetemcomitans is the homopolymer of ... | 2015 | 26221956 |
| antagonistic effect of peptidoglycan of streptococcus sanguinis on lipopolysaccharide of major periodontal pathogens. | streptococcus sanguinis is often found in subgingival biofilm including periodontopathogens, and is correlated with a delay in colonization by periodontopathogens. however, the effect of s. sanguinis on inflammation induced by periodontopathogens is poorly understood. thus, this study investigated the effect of s. sanguinis peptidoglycan (pgn) on induction of tnf-α, il-6, and il-8 expression by lipopolysaccharide (lps) of periodontal pathogens. lps was extracted from aggregatibacter actinomycete ... | 2015 | 26224458 |
| the toxicity of the aggregatibacter actinomycetemcomitans cytolethal distending toxin correlates with its phosphatidylinositol-3,4,5-triphosphate phosphatase activity. | the aggregatibacter actinomycetemcomitans cytolethal distending toxin (cdt) induces g2 arrest and apoptosis in lymphocytes and other cell types. we have shown that the active subunit, cdtb, exhibits phosphatidylinositol-3,4,5-triphosphate (pip3) phosphatase activity, leading us to propose that cdt toxicity is the result of pip3 depletion and perturbation of phosphatidylinositol-3-kinase (pi-3k)/pip3/akt signalling. to further explore this relationship, we have focused our analysis on identifying ... | 2016 | 26247396 |
| periodontal pathogens participate in synovitis in patients with rheumatoid arthritis in clinical remission: a retrospective case-control study. | the objective of this study was to investigate the role of periodontal pathogens in ra in remission. | 2015 | 26248812 |
| microbiologic and clinical findings of implants in healthy condition and with peri-implantitis. | to compare implants in healthy conditions and implants with peri-implantitis with regard to their clinical parameters and the microbiologic composition at the peri-implant sulcus, inside the implant connection, and the gingival sulcus of neighboring teeth. | 2016 | 26252036 |
| clinical and microbiologic evaluation of scaling and root planing per quadrant and one-stage full-mouth disinfection associated with azithromycin or chlorhexidine: a clinical randomized controlled trial. | conflicting data about the protocol of choice for non-surgical periodontal therapy with adjuvant use are still reported. this study aims to evaluate, through clinical and microbiologic parameters, the systemic use of azithromycin (az) and chlorhexidine (chx) as adjuvants to non-surgical periodontal treatment performed by one-stage full-mouth disinfection (fmd) within 24 hours or conventional quadrant scaling (qs) in four weekly sections. | 2015 | 26252751 |
| effect of aggregatibacter actinomycetemcomitans from aggressive periodontitis patients on streptococcus mutans. | to determine in vivo association between aggregatibacter actinomycetemcomitans (aa) and streptococcus mutans (sm) in aggressive periodontitis patients (agp) and the in vitro influence on sm of saliva and of aa strains isolated from individual aa-positive patients. | 2015 | 26258896 |
| oral bacteria in placental tissues: increased molecular detection in pregnant periodontitis patients. | the objective of this study was to identify the dna of oral bacteria in placental samples from women with and without periodontitis who had or had not had preterm births and/or low birthweight (pb/lbw) neonates. | 2015 | 26259070 |
| surface display of aggregatibacter actinomycetemcomitans autotransporter aae and dispersin b hybrid act as antibiofilm agents. | among the various proteins expressed by the periodontopathogen aggregatibacter actinomycetemcomitans, two proteins play important roles for survival in the oral cavity. the autotransporter aae facilitates the attachment of the pathogen to oral epithelial cells, which act as a reservoir, while the biofilm-degrading glycoside hydrolase dispersin b facilitates the movement of daughter cells from the mature biofilm to a new site. the objective of this study was to use the potential of these two prot ... | 2016 | 26280561 |
| investigation of the oral status and microorganisms in children with phenylketonuria and type 1 diabetes. | the aim of this study was to investigate the oral parameters that influence the caries risk and risk of developing periodontal disease in children with phenylketonuria (pku) and type 1 diabetes compared to healthy children. | 2016 | 26297129 |