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t lymphocyte responses to flaviviruses - diverse cell populations affect tendency toward protection and disease.dengue virus (denv), yellow fever virus, west nile virus, japanese encephalitis virus and zika virus are medically important flaviviruses transmitted to humans by mosquitoes and circulate in overlapping geographic areas. cross-reactive immune responses have been demonstrated among the flaviviruses, particularly the four denv serotypes. the immunological imprint left by a flavivirus infection can therefore have profound effects on the responses to subsequent infections. in this review we summariz ...202032810785
exploratory analysis of machine learning approaches for surveillance of zika-associated birth defects.in 2016, centers for disease control and prevention (cdc) established surveillance of pregnant women with zika virus infection and their infants in the u.s. states, territories, and freely associated states. to identify cases of zika-associated birth defects, subject matter experts review data reported from medical records of completed pregnancies to identify findings that meet surveillance case criteria (manual review). the volume of reported data increased over the course of the zika virus out ...202032815300
congenital zika virus infection in a birth cohort in vietnam, 2017-2018.to detect congenital zikv infection (czi) in a birth cohort and among high-risk neonates in vietnam, we collected umbilical cord blood plasma samples of newly delivered babies and peripheral plasma samples of high-risk neonates in nha trang, central vietnam, between july 2017 and september 2018. samples were subjected to serological and molecular tests. of the 2013 newly delivered babies, 21 (1%) were positive for zika virus (zikv) igm and 1,599 (79%) for flavivirus igg. among the 21 zikv igm-po ...202032815502
diagnostic limitations in congenital zika virus infection.this is the first documented case of an infant with congenital zika virus infection (zvi) born in ireland. a term infant was delivered with an antenatal diagnosis of severe microcephaly. first trimester bloods confirmed maternal zvi and although the infant did not have zika virus rna or zika-specific igm in her blood or urine, she had multiple clinical features of congenital zvi and zika virus rna was present in the placenta.202032816436
detailed analyses of zika virus tropism in culex quinquefasciatus reveal systemic refractoriness.the role of culex quinquefasciatus in zika virus transmission has been debated since the epidemic of zika occurred in the americas in 2015 to 2016. the majority of studies have found no evidence that c. quinquefasciatus or other culex species are competent vectors of zika virus, and the few studies that have proposed zika vector status for c. quinquefasciatus have relied predominantly on quantitative real-time pcr (qrt-pcr) for viral detection. we assessed the infectious range of pre- and post-e ...202032817107
differentiation-dependent susceptibility of human muscle cells to zika virus infection.muscle cells are potential targets of many arboviruses, such as ross river, dengue, sindbis, and chikungunya viruses, that may be involved in the physiopathological course of the infection. during the recent outbreak of zika virus (zikv), myalgia was one of the most frequently reported symptoms. we investigated the susceptibility of human muscle cells to zikv infection. using an in vitro model of human primary myoblasts that can be differentiated into myotubes, we found that myoblasts can be pro ...202032817655
zika virus infection, philippines, 2012. 202032818418
information-accessing behavior during zika virus outbreak, united states, 2016.we used latent class analysis to examine zika virus-related information-accessing behavior of us residents during the 2016 international outbreak. we characterized 3 classes of information-accessing behavior patterns: universalists, media seekers, and passive recipients. understanding these patterns is crucial to planning risk communication during an emerging health threat.202032818420
enhanced effect of modified zika virus e antigen on the immunogenicity of dna vaccine.it has been reported worldwide that the zika virus (zikv) could be transmitted through placentas and sexual contact. zikv can also cause guillain-barre syndrome, microcephaly and neurological abnormalities. however, there are no approved vaccines available. we constructed six dna vaccine candidates and tested the immunogenicity. tandem repeated envelope domain ⅲ (ed ⅲ × 3) induced highly total igg and neutralization antibody, as well as cd8+ t cell responses. also, stem region-removed envelope ( ...202032818729
continuous epileptiform discharges during sleep as an evolutionary pattern in patients with congenital zika virus syndrome.congenital zika virus syndrome (czvs) is associated with severe neurological deficits. clinical characteristics of epilepsy and the electroencephalographic (eeg) pattern in czvs were documented in infancy. in this study, we aimed to describe the eeg findings observed during the follow-up of children with czvs. seventy-six eegs of 55 children (60% female; mean age = 50 months) with confirmed czvs were analyzed, considering the background, interictal, and ictal epileptiform discharges. continuous ...202032820832
development of a potent zika virus vaccine using self-amplifying messenger rna.zika virus (zikv) is the cause of a pandemic associated with microcephaly in newborns and guillain-barre syndrome in adults. currently, there are no available treatments or vaccines for zikv, and the development of a safe and effective vaccine is a high priority for many global health organizations. we describe the development of zikv vaccine candidates using the self-amplifying messenger rna (sam) platform technology delivered by cationic nanoemulsion (cne) that allows bedside mixing and is par ...202032821824
post-fever retinitis - newer concepts.post-fever retinitis (pfr) is an infectious or para-infectious uveitic entity caused by bacterial or viral agents and seen mainly in tropical countries. systemic symptoms such as joint pain, skin rash are common during the febrile stage. on the basis of only clinical presentation, it is difficult to pin-point the exact etiology for pfr. serological investigations, polymerase chain reaction, and knowledge of concurrent epidemics in the community may help to identify the etiological organism. bact ...202032823394
label-free electrochemical biosensors for the determination of flaviviruses: dengue, zika, and japanese encephalitis.a highly effective way to improve prognosis of viral infectious diseases and to determine the outcome of infection is early, fast, simple, and efficient diagnosis of viral pathogens in biological fluids. among a wide range of viral pathogens, flaviviruses attract a special attention. flavivirus genus includes more than 70 viruses, the most familiar being dengue virus (denv), zika virus (zikv), and japanese encephalitis virus (jev). haemorrhagic and encephalitis diseases are the most common sever ...202032824351
papaya fruit pulp and resulting lactic fermented pulp exert antiviral activity against zika virus.there are a several emerging and re-emerging rna viruses that are prevalent around the world for which there are no licensed vaccines or antiviral drugs. zika virus (zikv) is an example of an emerging virus that has become a significant concern worldwide because of its association with severe congenital malformations and neurological disorders in adults. several polyphenol-rich extracts from plants were used as nutraceuticals which exhibit potent in vitro antiviral effects. here, we demonstrated ...202032825246
a review of the control of aedes aegypti (diptera: culicidae) in the continental united states.aedes aegypti (l) is an anthropophilic mosquito involved in the transmission of a variety of viral pathogens worldwide including dengue, chikungunya, yellow fever, and zika viruses. this species, native to africa, is well established in the continental u.s. (conus) and occasionally contributes to localized outbreaks of viral diseases. in the last seven decades, mosquito control programs in the conus have been focused on vectors of eastern equine encephalitis, st. louis encephalitis, and west nil ...202032829398
teratogen update: zika virus and pregnancy.zika virus was first identified in uganda in 1947 but received little attention until 2015 when a large outbreak of zika virus illness followed by an increased number of babies born with microcephaly occurred in brazil. zika virus spread rapidly throughout the americas, and in 2016 was identified as a cause of microcephaly and other serious birth defects. since that time, much has been learned about the zika virus. the virus is primarily spread by the bite of aedes species mosquitoes; however, o ...202032830420
fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions.the earliest possible diagnosis and understanding of the infection mechanisms play a crucial role in the outcome of fighting viral diseases. thus, we designed and developed for the first time, novel bioconjugates made of ag-in-s@zns (zais) fluorescent quantum dots coupled with zika virus via covalent amide bond with carboxymethylcellulose (cmc) biopolymer for labeling and bioimaging the virus-host cell interactions mechanisms through confocal laser scanning microscopy. this work offers relevant ...202032834256
the state of one health research across disciplines and sectors - a bibliometric analysis.there is a growing interest in one health, reflected by the rising number of publications relating to one health literature, but also through zoonotic disease outbreaks becoming more frequent, such as ebola, zika virus and covid-19. this paper uses bibliometric analysis to explore the state of one health in academic literature, to visualise the characteristics and trends within the field through a network analysis of citation patterns and bibliographic links. the analysis focuses on publication ...202032835067
are hospitals our friends? an exploratory study on the role of facebook in hospital organizations' dialogic communication.rooted in the dialogic public relations model, the aim of this paper was to analyze the way in which hospital organizations use facebook to communicate and build relationships with their patients and followers. using a content analysis of facebook profiles, there is a reflection on how dialogic principles are applied in the management of facebook by hospitals in portugal. special attention will be paid to communication regarding the zika virus, which was of public interest at the time the empiri ...202032835646
whole virus detection using aptamers and paper-based sensor potentiometry.paper-based sensors, microfluidic platforms, and electronics have attracted attention in the past couple of decades because they are flexible, can be recycled easily, environmentally friendly, and inexpensive. here we report a paper-based potentiometric sensor to detect the whole zika virus with a minimum sensitivity of 0.26 nv/zika and a minimum detectable signal (mds) of 2.4x107 zika. our paper sensor works very similar to a p-n junction where a junction is formed between two different regions ...202032838210
a model partnership for communication and dissemination of scientific recommendations for pregnant women during the emergency response to the zika virus outbreak: mothertobaby and the centers for disease control and prevention.during the zika virus (zikv) outbreak, an urgent need existed for strong partnerships to disseminate zika-related information to pregnant women and women of child-bearing age.202032840950
requests for medication abortion support in brazil during and after the zika epidemic.brazil declared a public health emergency during the zika virus epidemic, recommending avoiding pregnancy. this study analyses requests received by women help women for information about and support for self-managed medication abortion (ma) in brazil during and after the zika epidemic to understand how zika may have impacted requests to the service. this analysis considered 20,609 requests for ma support received between january 2016 and june 2017. reasons for seeking an abortion were analysed a ...202032841056
n-glycosylation in the pre-membrane protein is essential for the zika virus life cycle.asparagine (n)-linked protein glycosylation plays an important role in protein synthesis and modification. two zika virus (zikv) structural proteins, the pre-membrane (prm) and envelope (e) protein are n-glycosylated. the prm protein of all zikv strains contains a single n-linked glycosylation site, while not all strains contain an n-linked site in the e protein. our aim was to examine the impact of prm and e n-linked glycosylation on zikv infectivity and cell trafficking. using a zikv infectiou ...202032842538
in vitro inhibition of zika virus replication with poly(sodium 4-styrenesulfonate).zika virus (zikv) is an emerging mosquito-borne pathogen associated with microcephaly and other congenital abnormalities in newborns as well as neurologic complications in adults. the explosive transmission of the virus in the last ten years put it in the limelight and improved our understanding of its biology and pathology. currently, no vaccine or drugs are available to prevent or treat zikv infections. knowing the potential of flaviviruses to broaden their geographic distribution, as observed ...202032842540
recent progress in plasmonic biosensing schemes for virus detection.the global burden of coronavirus disease 2019 (covid-19) to public health and global economy has stressed the need for rapid and simple diagnostic methods. from this perspective, plasmonic-based biosensing can manage the threat of infectious diseases by providing timely virus monitoring. in recent years, many plasmonics' platforms have embraced the challenge of offering on-site strategies to complement traditional diagnostic methods relying on the polymerase chain reaction (pcr) and enzyme-linke ...202032842601
repositioning and investigational drugs for zika virus infection treatment: a patent review.zika virus (zikv) is transmitted to humans throughout bites of aedes mosquitoes. zikv infection may be asymptomatic in most cases, but it may cause fever, headache, muscle pain, and rash. guillain-barré syndrome also may be associated with the infection. furthermore, the pan american health organization informed 3,715 cases of the congenital zikv syndrome (czs) in the americas from 2015 - 2017, which may include microcephaly and other craniofacial deformities.202032842803
il-22 hinders antiviral t cell responses and exacerbates zikv encephalitis in immunocompetent neonatal mice.the zika virus (zikv) outbreak that occurred in multiple countries was linked to increased risk of nervous system injuries and congenital defects. however, host immunity- and immune-mediated pathogenesis in zikv infection are not well understood. interleukin-22 (il-22) is a crucial cytokine for regulating host immunity in infectious diseases. whether il-22 plays, a role in zikv infection is unknown.202032843067
quality of life of mothers of children with congenital syndrome affected by zika virus.to investigate how mothers of children with congenital syndrome (microcephaly) associated with zika virus perceive their quality of life.202132844897
congenital zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth.this study analyzed possible associations between the trimester of maternal zika virus infection (zikv) in pregnancy, severity of brain computed tomography (ct) findings and the presence of microcephaly at birth in children with congenital zika syndrome (czs). it was an analytical study in a cohort of children with czs. symptoms of maternal infection were dichotomized into the 1st trimester of pregnancy and other trimesters. head circumference (hc) at birth was used to calculate the z-score. mil ...202032844907
increase in guillain-barré syndrome hospitalizations in brazil: an ecological study.objective to describe the demographic characteristics and the spatio-temporal dynamics of guillain-barré syndrome (gbs) hospitalizations in brazil between 2008 and 2017. methods this is an ecological study using data from the hospital information system of the brazilian national health system (sih/sus); gbs hospitalization rates were calculated and a control diagram was built; natural break ranges were used in the spatial analysis. results 15,512 gbs hospitalizations were recorded during the stu ...202032844917
dzc diag: mobile application based on expert system to aid in the diagnosis of dengue, zika, and chikungunya.dengue, zika, and chikungunya are epidemic diseases transmitted by the aedes mosquito. these virus infections can be so severe to the point of bringing on mobility and neurological problems, or even death. expert systems (es) can be used as tools for the identification of patterns intended to solve problems in the same way as a professional specialist would. this work aimed to develop an es in the form of an android application to serve as a supportive tool in the diagnosis of these arboviruses. ...202032845437
zika; a continuous global threat to public health.zika virus is transmitted by aedes mosquitoes, especially, ae. aegypti and ae. albopictus. about 80% of the cases do not manifest any symptoms, and it is a self-limiting, mild viral infection. in 20% of the cases and only in fraction of those who do show the symptoms, important complications including guillaine barre'syndrome and microcephaly may occur. the emergence of zika in 2016 in brazil spreading to about 70 other countries prompted the who officials to declare the disease a public health ...202032846650
zika virus replication in myeloid cells during acute infection is vital to viral dissemination and pathogenesis in a mouse model.zika virus (zikv) can establish infection in immune privileged sites such as the testes, eye, and placenta. whether zikv infection of white blood cells is required for dissemination of the virus to immune privileged sites has not been definitively shown. to assess whether initial zikv replication in myeloid cell populations is critical for dissemination during acute infection, recombinant zikvs were generated that could not replicate in these specific cells. zikv was cell restricted by insertion ...202032847848
wolbachia inhibits binding of dengue and zika viruses to mosquito cells.as traditional approaches to the control of dengue and zika are insufficient, significant efforts have been made to develop utilization of the endosymbiotic bacterium wolbachia to reduce the ability of mosquitoes to transmit pathogens. although wolbachia is known to inhibit flaviviruses in mosquitoes, including dengue virus (denv) and zika virus (zikv), it remains unclear how the endosymbiont interferes with viral replication cycle. in this study, we have carried out viral binding assays to inve ...202032849379
snake cathelicidin derived peptide inhibits zika virus infection.zika virus (zikv) is a mosquito-borne virus belonging to the genus flavivirus and has reemerged in recent years with epidemic potential. zikv infection may result in severe syndromes such as neurological complications and microcephaly in newborns. therefore, zikv has become a global public health threat and currently there is no approved specific drug for its treatment. animal venoms are important resources of novel drugs. cathelicidin-bf (bf-30) is a defensive peptide identified from bungarus f ...202032849457
zika infection disrupts proteins involved in the neurosensory system.newly re-emerging viruses are of great global concern, especially when there are no therapeutic interventions available during the time of an outbreak. there are still no therapeutic interventions for the prevention of zika virus (zikv) infections despite its resurgence more than a decade ago. newborns infected with zikv suffer from microcephaly and delayed neurodevelopment, but the underlying causes are largely unknown. all viruses hijack the host cellular machinery to undergo successful replic ...202032850779
speech-language disorders in children with congenital zika virus syndrome: a systematic review.having verified the true association between the zika virus and the occurrence of microcephaly, studies were conducted to evaluate the effects of the infection on fetal development. congenital zika virus syndrome is a currently known condition but little addressed regarding speech, language, and hearing disorders in children.202032853874
sexual transmission of arboviruses: a systematic review.arthropod-borne viruses (arboviruses) are primarily maintained in nature in transmission cycles between hematophagous arthropods and vertebrate hosts, but an increasing number of arboviruses have been isolated from or indirectly detected in the urogenital tract and sexual secretions of their vertebrate hosts, indicating that further investigation on the possibility of sexual transmission of these viruses is warranted. the most widely recognized sexually-transmitted arbovirus is zika virus but ot ...202032854298
zika virus increases risk of dengue disease. 202032855325
zika virus infection enhances future risk of severe dengue disease.the zika pandemic sparked intense interest in whether immune interactions among dengue virus serotypes 1 to 4 (denv1 to -4) extend to the closely related zika virus (zikv). we investigated prospective pediatric cohorts in nicaragua that experienced sequential denv1 to -3 (2004 to 2015), zika (2016 to 2017), and denv2 (2018 to 2020) epidemics. risk of symptomatic denv2 infection and severe disease was elevated by one prior zikv infection, one prior denv infection, or one prior denv infection foll ...202032855339
strategies and safeguards to ensure access to long-acting reversible contraception removal after the zika contraception access network ended: a prospective analysis of patient reported complaints.the zika contraception access network (z-can) was a short-term emergency response intervention that used contraception to prevent unintended pregnancy to reduce zika-related adverse birth outcomes during the 2016 2017 zika virus outbreak in puerto rico. strategies and safeguards were developed to ensure women who chose long-acting reversible contraception (larc) had access to no-cost removal, if desired, after z-can ended.202032858052
microphysiological systems of the placental barrier.methods to evaluate maternal-fetal transport across the placental barrier have generally involved clinical observations after-the-fact, ex vivo perfused placenta studies, or in vitro transwell assays. given the ethical and technical limitations in these approaches, and the drive to understand fetal development through the lens of transport-induced injury, such as with the examples of thalidomide and zika virus, efforts to develop novel approaches to study these phenomena have expanded in recent ...202032858104
ml-sa1, a selective trpml agonist, inhibits denv2 and zikv by promoting lysosomal acidification and protease activity.arboviruses, especially dengue virus (denv) and zika virus (zikv), have been a severe threat to human health in the last few years due to uncontrollable transmission. there are no approved vaccines or clinical drugs available for use to prevent and treat their infections. transient receptor potential mucolipin 2 and 3 (trpml2 and trpml3) were reported to modulate viral entry, but the antiviral function of these modulators was unknown. here, we reported that ml-sa1, a trpml agonist, inhibited den ...202032858116
jmx0207, a niclosamide derivative with improved pharmacokinetics, suppresses zika virus infection both in vitro and in vivo.flaviviruses causes significant human disease. recent outbreaks of the zika virus highlight the need to develop effective therapies for this class of viruses. previously we identified niclosamide as a broad-spectrum inhibitor for flaviviruses by targeting the interface between viral protease ns3 and its cofactor ns2b. here, we screened a small library of niclosamide derivatives and identified a new analogue with improved pharmacokinetic properties. compound jmx0207 showed improved efficacy in in ...202032866370
recent advances in the development of virus-like particle-based flavivirus vaccines.flaviviruses include several medically important viruses, such as zika virus (zikv), dengue virus (denv), west nile virus (wnv) and japanese encephalitis virus (jev). they have expanded in geographic distribution and refocused international attention in recent years. vaccination is one of the most effective public health strategies for combating flavivirus infections. in this review, we summarized virus-like particle (vlp)-based vaccines against the above four mentioned flaviviruses. potential s ...202032867194
transcriptomic analyses of aedes aegypti cultured cells and ex vivo midguts in response to an excess or deficiency of heme: a quest for transcriptionally-regulated heme transporters.aedes aegypti is the principle vector of many arboviruses, including dengue virus and zika virus, which are transmitted when an infected female mosquito takes a blood meal in order to initiate vitellogenesis. during blood digestion, ~ 10 mm heme-iron is ingested into the midgut lumen. while heme acts as both a nutrient and signaling molecule during blood digestion, it can also be highly toxic if left unchaperoned. both signaling by, and degradation of, heme are intracellular processes, occurring ...202032867680
zika virus ns4a cytosolic region (residues 1-48) is an intrinsically disordered domain and folds upon binding to lipids.in flaviviruses, the ns4a is an integral transmembrane protein that contributes to form virus-induced membrane curvature. however, structural features of ns4a are not documented in zika virus, and it is one of the least characterized proteins. thus, this work focused on investigating the secondary structural elements of the zika virus ns4a, where we characterized the cytosolic region of protein ns4a (residues 1-48) under variable environmental conditions. we found ns4a (residues 1-48) as an intr ...202032871423
dysregulation of ephrin receptor and ppar signaling pathways in neural progenitor cells infected by zika virus.zika virus (zikv) infection is a serious public threat with cases reported in about 70 countries and territories. one of the most serious consequences of zikv infection is congenital microcephaly in babies. congenital microcephaly has been suggested to result from infection of neural progenitor cells (npcs) in the developing fetal brain. however, the molecular and cellular mechanisms underlying microcephaly development remains to be fully elucidated. in this study, we employed quantitative prote ...202032873194
public health response to zika virus exposure of air force members deployed to caribbean islands, 2016.the emergence of zika virus disease (zvd) in areas of military operations provided a new opportunity for force health protection. zvd infection had an estimated 4:1 asymptomatic-to-symptomatic ratio and can cause neurologic sequelae.202032875318
brazil's missing infants: zika risk changes reproductive behavior.zika virus epidemics have potential large-scale population effects. controlled studies of mice and nonhuman primates indicate that zika affects fecundity, raising concerns about miscarriage in human populations. in regions of brazil, zika risk peaked months before residents learned about the epidemic and its relation to congenital anomalies. this spatiotemporal variation supports analysis of both biological effects of zika infection on fertility and the effects of learning about zika risk on rep ...202032875482
[mental health from the perspective of women affected by the zika virus: an ethnographic study in pará state, brazil].the current study reflects on the zika virus outbreak that struck the brazilian population, with both physical and emotional aspects for all those affected. there is a particular group that has to deal on a daily basis with all the difficulties imposed by this new reality: women. the basic assumption of this approach is the need to learn about, understand, and grasp these biopsychosocial issues in all their breadth. it becomes necessary to delve into a relatively new context that mainly affected ...202032876126
"it was god's will": continuing pregnancy after perinatal infection by zika virus.to understand the influence of the religious beliefs on the decision of a group of women residing in the huila department to continue their pregnancies despite perinatal infection by the zika virus.202032876288
identification of zika virus inhibitors using homology modeling and similarity-based screening to target glycoprotein e.the world health organization has designated zika virus (zikv) as a dangerous, mosquito-borne pathogen that can cause severe developmental defects. the primary goal of this work was identification of small molecules as potential zikv inhibitors that target the viral envelope glycoprotein (zikv e) involved in membrane fusion and viral entry. a homology model of zikv e containing the small molecule β-octyl glucoside (bog) was constructed, on the basis of an analogous x-ray structure from dengue vi ...202032876433
[zika virus infection: what advice in post-epidemic situation?]zika virus infection: what advice in post-epidemic situation? zika virus transmission is vector-borne, but it can also be sexual. the zika disease contracted by an adult or child is most often mild but infection of the woman during pregnancy can lead to severe neurological congenital lesions. the zika virus continues to circulate in many parts of the world. risk of infection during travel is low but cannot be overlooked. an infected man can be infectious, during sexual intercourse, up to 3 month ...202032877071
anti-flavivirus vaccines: review of the present situation and perspectives of subunit vaccines produced in escherichia coli.this article aims to review the present status of anti-flavivirus subunit vaccines, both those at the experimental stage and those already available for clinical use. aspects regarding development of vaccines to yellow fever virus, (yfv), dengue virus (denv), west nile virus (wnv), zika virus (zikv), and japanese encephalitis virus (jev) are highlighted, with particular emphasis on purified recombinant proteins generated in bacterial cells. currently licensed anti-flavivirus vaccines are based o ...202032878023
mechanistic target of rapamycin signaling activation antagonizes autophagy to facilitate zika virus replication.zika virus (zikv), a mosquito-transmitted flavivirus, is linked to microcephaly and other neurological defects in neonates and guillain-barré syndrome in adults. the molecular mechanisms regulating zikv infection and pathogenic outcomes are incompletely understood. signaling by the mechanistic (mammalian) target of rapamycin (mtor) kinase is important for cell survival and proliferation, and viruses are known to hijack this pathway for their replication. here, we show that in human neuronal prec ...202032878890
an overview of the current medical literature on zika virus.zika virus is a member of the family of flaviviridae, which is primarily spread to humans by mosquito bites. it has been linked to microcephaly in neonates, and as such, it poses a significant risk to human pregnancy. zika virus infection is also implicated in other severe neurological disorders such as guillain-barre syndrome. there is currently no vaccine available to treat zika virus disease, and as such, it represents a serious challenge to public health. antigenic similarities between zika ...202032880054
congenital zika virus infection: a review with emphasis on the spectrum of brain abnormalities.in 2016, the world health organization declared the zika virus (zikv) outbreak a public health emergency of international concern following a cluster of associated neurological disorders and neonatal malformations. our aim is to review the clinical and neuroimaging findings seen in congenital zika syndrome.202032880775
feeding modifications and additional primary caregiver support for infants exposed to zika virus or diagnosed with congenital zika syndrome: a rapid review of the evidence.infants exposed to zika virus (zikv) or diagnosed with congenital zika syndrome (czvs) may present dysphagia, regurgitation and other feeding difficulties. they may require special feeding practices to minimise the risk of mortality, morbidity and developmental problems. improving knowledge, skills and behaviours of caregivers may preserve health, maximise development and promote quality of life among affected infants. we reviewed intervention studies of modified feeding practices and additional ...202032881216
cohort profile: congenital zika virus infection and child neurodevelopmental outcomes; zika en embarazadas y niños (zen) cohort study in colombia.zika en embarazadas y niños (zen) is a prospective cohort study designed to identify risk factors and modifiers for zika virus (zikv) infection in pregnant women, partners, and infants, as well as assess the risk for adverse maternal, fetal, infant, and childhood outcomes of zikv and other congenital infections. zikv infection during pregnancy may be associated with long-term sequelae. 1519 pregnant women and 287 partners were enrolled from three departments within colombia between february 2017 ...202032882120
ns1-based dna vaccination confers mouse protective immunity against zikv challenge.the recent pandemic of zika virus (zikv) infections highlight the urgent need for the development of a safe and efficacious zikv vaccine. we previously demonstrated that robust humoral and cellular immunity was elicited in balb/c mice by zikv dna vaccine encoding the precursor membrane (prm) and envelope (e) proteins while the protective efficacies were not evaluated against zikv challenge. to further explore the protective immunity elicited by various targets of zikv, we constructed a novel dna ...202032882433
evaluation of larvicidal efficacy of ricinus communis (castor) and synthesized green silver nanoparticles against aedes aegypti l.aedes mosquitoes are the most important group of vectors that transmit pathogens, including arboviruses, and cause human diseases such as dengue fever, yellow fever, zika virus, and chikungunya. biosynthesis and the use of green silver nanoparticles (agnps) is a vital step to identify reliable and eco-friendly controls for these vectors. in this study, aedes (ae.) aegypti larvae (2nd and 3rd instar) were exposed to leaf extracts of ricinus communis (castor) and agnps synthesized from the extract ...202032884423
comparison of oropharyngeal dysphagia in brazilian children with prenatal exposure to zika virus, with and without microcephaly.severe brain damage associated with zika-related microcephaly (zrm) have been reported to result in oropharyngeal dysphagia (opd); however, it is unknown if opd presents in children with prenatal zika virus (zikv) exposure but only mild or undetectable abnormalities. the aims of this study were: to compare the frequency and characteristics of opd in children with zrm and in children without microcephaly born to mothers who tested polymerase chain reaction positive (pcr+) for zikv during pregnanc ...202032886254
lab-on-a-chip zika detection with reverse transcription loop-mediated isothermal amplification-based assay for point-of-care settings.zika virus (zikv) infection, primarily transmitted by mosquitoes, causes various neurologic disorders. to differentiate zikv from other arboviruses, such as dengue, chikungunya, and yellow fever viruses, a highly specific, sensitive, and automated detection system is needed for point-of-care (poc) settings.202032886758
a zika vaccine generated using the chimeric insect-specific binjari virus platform protects against fetal brain infection in pregnant mice.zika virus (zikv) is the etiological agent of congenital zika syndrome (czs), a spectrum of birth defects that can lead to life-long disabilities. a range of vaccines are in development with the target population including pregnant women and women of child-bearing age. using a recently described chimeric flavivirus vaccine technology based on the novel insect-specific binjari virus (binjv), we generated a zikv vaccine (binj/zika-prme) and illustrate herein its ability to protect against fetal br ...202032887302
follow-up household serosurvey in northeast brazil for zika virus: sexual contacts of index patients have the highest risk for seropositivity.zika virus (zikv) is a mosquito-borne virus that is also transmitted sexually, however, the epidemiological relevance of zikv sexual transmission in endemic regions is unclear.202032888023
oral lesions in patients with sars-cov-2 infection: could the oral cavity be a target organ?several viruses transmitted through saliva, such as herpes simplex virus, cytomegalovirus, and zika virus, are capable of infecting and replicating in the oral mucosa, leading to painful oral ulcers. few studies have described the oral manifestations of coronavirus disease 2019 (covid-19). there is growing evidence that angiotensin-converting enzyme 2 (ace2), the main host cell receptor of severe acute respiratory syndrome coronavirus 2 (sars-cov-2), is highly expressed on the epithelial cells o ...202032888876
pregnant women's perceptions of risks and benefits when considering participation in vaccine trials.despite historical exclusion, there has been recent recognition of the need to address the health of pregnant women in research on vaccines against emerging pathogens. however, pregnant women's views and decision-making processes about vaccine research participation during infectious disease outbreaks remain underexplored. this study aims to examine women's decision-making processes around vaccine research participation during infectious disease outbreaks.202032893036
understanding microcephaly through the study of centrosome regulation in drosophila neural stem cells.microcephaly is a rare, yet devastating, neurodevelopmental condition caused by genetic or environmental insults, such as the zika virus infection. microcephaly manifests with a severely reduced head circumference. among the known heritable microcephaly genes, a significant proportion are annotated with centrosome-related ontologies. centrosomes are microtubule-organizing centers, and they play fundamental roles in the proliferation of the neuronal progenitors, the neural stem cells (nscs), whic ...202032897294
zika virus transmission by brazilian aedes aegypti and aedes albopictus is virus dose and temperature-dependent.zika virus (zikv) emerged in the pacific ocean and subsequently caused a dramatic pan-american epidemic after its first appearance in the northeast region of brazil in 2015. the virus is transmitted by aedes mosquitoes. we evaluated the role of temperature and infectious doses of zikv in vector competence of brazilian populations of ae. aegypti and ae. albopictus.202032898136
zika virus induces myocardial immune response and myocarditis in mice. 202032898533
advances in neonatal infections.despite continued advances and developments in neonatal medicine, neonatal sepsis is the third leading cause of neonatal mortality and a major public health problem, especially in developing countries. sepsis accounts for mortality for almost 50% of global children under 5 years of age.over the past 50 years, there have been many advances in the diagnosis, prevention, and treatment of neonatal infections. the diagnostic advances include better culture techniques that permit more rapid confirmati ...202032898875
mrna and mirna profiling of zika virus-infected human umbilical cord mesenchymal stem cells identifies mir-142-5p as an antiviral factor.zika virus (zikv) infection during pregnancy is associated with congenital brain abnormalities, a finding that highlights the urgent need to understand mother-to-fetus transmission mechanisms. human umbilical cord mesenchymal stem cells (hucmscs) are susceptible to zikv infection but the underlying mechanisms of viral susceptibility remain largely unexplored. in this study, we have characterized and compared host mrna and mirna expression profiles in hucmscs after infection with two lineages of ...202032902370
harringtonine inhibits zika virus infection through multiple mechanisms.mosquito-borne zika virus (zikv) is a flavivirus that came under intense study from 2014 to 2016 for its well-known ability to cause congenital microcephaly in fetuses and neurological guillain-barré disease in adults. substantial research on screening antiviral agents against zikv and preventing zikv infection are globally underway, but food and drug administration (fda)-approved treatments are not available yet. compounds from chinese medicinal herbs may offer an opportunity for potential ther ...202032906689
high sensitivity of one-step real-time reverse transcription quantitative pcr to detect low virus titers in large mosquito pools.mosquitoes are the deadliest animals in the world. their ability to carry and spread diseases to humans causes millions of deaths every year. due to the lack of efficient vaccines, the control of mosquito-borne diseases primarily relies on the management of the vector. traditional control methods are insufficient to control mosquito populations. the sterile insect technique (sit) is an additional control method that can be combined with other control tactics to suppress specific mosquito populat ...202032907625
first aid intervention with mothers/caregivers of children affected by the zika virus in brazil.children with microcephaly associated with the zika virus are more likely to develop choking and apnea, so it is necessary that mothers of this population receive first aid training to cope with emergency situations that their children may experience.202032907768
neural progenitor cell pyroptosis contributes to zika virus-induced brain atrophy and represents a therapeutic target.mounting evidence has associated zika virus (zikv) infection with congenital malformations, including microcephaly, which raises global alarm. nonetheless, mechanisms by which zikv disrupts neurogenesis and causes microcephaly are far from being understood. in this study, we discovered direct effects of zikv on neural progenitor cell development by inducing caspase-1- and gasdermin d (gsdmd)-mediated pyroptotic cell death, linking zikv infection with the development of microcephaly. importantly, ...202032907937
accelerating the morphogenetic cycle of the viral vector aedes aegypti larvae for faster larvicidal bioassays.any bioassay to test new chemically synthesized larvicides or phytolarvicides against culicidae and more harmful mosquito species, such as aedes aegypti and aedes albopictus, which specifically transmit dengue, yellow fever, chikungunya viral fevers as well as zika virus, or anopheles gambiae, a vector for malaria and philariasis, requires thousands of well-developed larvae, preferably at the fourth instar stage. the natural morphogenetic cycle of aedes spp., in the field or in the laboratory, m ...202032908910
the kv1.3 ion channel acts as a host factor restricting viral entry.virus entry into cells is the initial stage of infection and involves multiple steps, and interfering viral entry represents potential antiviral approaches. ion channels are pore-forming membrane proteins controlling cellular ion homeostasis and regulating many physiological processes, but their roles during viral infection have rarely been explored. here, the functional kv1.3 ion channel was found to be expressed in human hepatic cells and tissues. the kv1.3 was then revealed to restrict hcv en ...202032910509
electrical status epilepticus during sleep in patients with congenital zika virus syndrome: an unprecedented clinical finding.brazil experienced a disproportionately higher rate of microcephaly cases in november 2015 with evidence of a causal link with zika virus (zikv) infections during pregnancy. epilepsy is a major neurological feature seen as part of congenital zika virus syndrome (czvs). different seizure types and electroencephalographic (eeg) abnormalities have been described in association with this syndrome. however, clinical and neurophysiological features of epilepsy seen in children with czvs are not fully ...202032911235
modulation of acyl-carnitines, the broad mechanism behind wolbachia-mediated inhibition of medically important flaviviruses in aedes aegypti.wolbachia-infected mosquitoes are refractory to flavivirus infections, but the role of lipids in wolbachia-mediated virus blocking remains to be elucidated. here, we use liquid chromatography mass spectrometry to provide a comprehensive picture of the lipidome of aedes aegypti (aag2) cells infected with wolbachia only, either dengue or zika virus only, and wolbachia-infected aag2 cells superinfected with either dengue or zika virus. this approach identifies a class of lipids, acyl-carnitines, as ...202032913052
mothers as facilitators for a parent group intervention for children with congenital zika syndrome: qualitative findings from a feasibility study in brazil.the zika virus outbreak in brazil (2015-2016) affected thousands of children who were born with congenital zika syndrome (czs). families play an important role in their care of children with complex needs, yet their knowledge, experience and skills are rarely harnessed in existing interventions to best support these families.202032913354
assessing the quality of the systems of care for children with congenital zika virus infection and other neurodevelopmental disabilities in the united states pacific island territories.congenital zika virus (zikv) infection can cause lifelong medical and developmental conditions and management needs. there is limited information on the strengths and weaknesses of the systems of care for addressing zikv and other neurodevelopmental disabilities (nrd) in the united states (us) affiliated pacific island territories. therefore, the purpose of the study was to assess the quality of the chronic illness systems of care for children with congenital zikv and other nrd in the us pacific ...202032914095
the anti-zika virus and anti-tumoral activity of the citrus flavanone lipophilic naringenin-based compounds.flavonoids are natural products widely recognized for their plurality of applications such as antiviral, antiproliferative, antitumor activities and, antioxidant properties. the flavanone naringenin is presented in citrus fruits and has been studied to combat recurrent diseases that still lack effective treatment. research groups have been investing efforts to the development of new, safe and active candidates to combat these agents or conditions and despite good results recently reported agains ...202032916141
inhibition of zika virus infection by fused tricyclic derivatives of 1,2,4,5-tetrahydroimidazo[1,5-a]quinolin-3(3ah)-one.zika virus (zikv) infection represents a significant threat to the global health system, and the search for efficient antivirals to zikv remains necessary and urgent. in this study, we extended the exploration of our previously discovered scaffold of 1h-pyrrolo[1,2-c]imidazol-1-one and revealed that two trans isomers of compounds 2 and 7 and one mixture with major trans isomer of compound 3 as novel tetrahydroquinoline-fused imidazolone derivatives are active against zikv infection but they are ...202032916389
zika virus enhances dengue risk. 202032918039
contraception and post abortion services: qualitative analysis of users' perspectives and experiences following zika epidemic in honduras.zika virus (zikv) infection during pregnancy has severe consequences on the new-born. the world health organization declared the zika outbreak to be a public health emergency of international concern (pheic) in 2016. health facilities in the regions most affected by zika lacked the capacity to respond to the increased demand for contraception. the objectives were to explore healthcare users' perceptions regarding contraception, zika prevention during pregnancy and post-abortion care (pac) servic ...202032919474
unfolding the future: self-controlled catalytic nanomotor in healthcare system.nanomotors, multimetallic systems are biologically inspired self-propelled tiny engines able to perform difficult tasks of transporting cargos from one end to another in presence of hydrogen peroxide fuel. nanomotors can revolutionize the drug delivery system at the desired target by converting chemical energy into mechanical energy. nanomotors exhibit unique properties like moving at higher speed, self-propulsion and drilling into the complex cellular environment. the review focuses on fuel dep ...202032919683
early maternal zika infection predicts severe neonatal neurological damage: results from the prospective natural history of zika virus infection in gestation cohort study.to define the prevalence of adverse outcomes of maternal infection in a large cohort of zikv-infected brazilian women and their infants.202032920998
viruses harness yxxø motif to interact with host ap2m1 for replication: a vulnerable broad-spectrum antiviral target.targeting a universal host protein exploited by most viruses would be a game-changing strategy that offers broad-spectrum solution and rapid pandemic control including the current covid-19. here, we found a common yxxø-motif of multiple viruses that exploits host ap2m1 for intracellular trafficking. a library chemical, n-(p-amylcinnamoyl)anthranilic acid (aca), was identified to interrupt ap2m1-virus interaction and exhibit potent antiviral efficacy against a number of viruses in vitro and in vi ...202032923629
zika virus ns2a protein induces the degradation of kpna2 (karyopherin subunit alpha 2) via chaperone-mediated autophagy.kpna2/importin-alpha1 (karyopherin subunit alpha 2) is the primary nucleocytoplasmic transporter for some transcription factors to activate cellular proliferation and differentiation. aberrant increase of kpna2 level is identified as a prognostic marker in a variety of cancers. yet, the turnover mechanism of kpna2 remains unknown. here, we demonstrate that kpna2 is degraded via the chaperone-mediated autophagy (cma) and that zika virus (zikv) enhances the kpna2 degradation. kpna2 contains a cma ...202032924767
association between congenital cytomegalovirus and the prevalence at birth of microcephaly in the united states.congenital cytomegalovirus (ccmv) has received far less clinical and public health attention as a teratogenic infection than the zika virus epidemic. however, ccmv may be responsible for a large fraction of microcephaly cases in the united states.202032926077
the innate immune response in zika virus infection.zika virus (zikv; flaviviridae, flavivirus) was discovered in 1947 in uganda, africa, from the serum of a sentinel rhesus monkey (macaca mulatta). it is an enveloped, positive-sense, single-stranded rna virus, which encodes a single polyprotein that is cleaved into 10 individual proteins. in 2015, the zika-epidemic in brazil was marked mainly by the exponential growth of microcephaly cases and other congenital defects. with regard to host-pathogen relationships, understanding the role of the imm ...202032926478
further sar on the (phenylsulfonyl)piperazine scaffold as inhibitors of the aedes aegypti kir1 (aekir) channel and larvicides.zika virus (zikv), dengue fever (denv) and chikungunya (chikv) are arboviruses that are spread to humans from the bite of an infected adult female aedes aegypti mosquito. as there are no effective vaccines or therapeutics for these diseases, the primary strategy for controlling the spread of these viruses is to prevent the mosquito from biting humans through the use of insecticides. unfortunately, the commonly used classes of insecticides have seen a significant increase in resistance, thus comp ...202032926544
supramolecular mechanism of viral envelope disruption by molecular tweezers.broad-spectrum antivirals are powerful weapons against dangerous viruses where no specific therapy exists, as in the case of the ongoing sars-cov-2 pandemic. we discovered that a lysine- and arginine-specific supramolecular ligand (clr01) destroys enveloped viruses, including hiv, ebola, and zika virus, and remodels amyloid fibrils in semen that promote viral infection. yet, it is unknown how clr01 exerts these two distinct therapeutic activities. here, we delineate a novel mechanism of antivira ...202032926779
sterility of gamma-irradiated pathogens: a new mathematical formula to calculate sterilizing doses.in recent years there has been increasing advocacy for highly immunogenic gamma-irradiated vaccines, several of which are currently in clinical or pre-clinical trials. importantly, various methods of mathematical modelling and sterility testing are employed to ensure sterility. however, these methods are designed for materials with a low bioburden, such as food and pharmaceuticals. consequently, current methods may not be reliable or applicable to estimate the irradiation dose required to steril ...202032930781
the neurodevelopmental spectrum of congenital zika infection: a scoping review.to describe the standardized neurodevelopmental outcomes after the first year of life in children with congenital zika syndrome (czs) and those exposed to zika virus (zikv) during fetal life, but without microcephaly at birth.202032931050
uncertainties, fear and stigma: perceptions of zika virus among pregnant women in spain.similar to other epidemics, knowledge about zika virus (zikv) relies upon information often coming from outside the health system. this study aimed to explore views, perceptions and attitudes towards zikv among migrant women from central and south america, diagnosed with zikv infection during pregnancy, and to comprehend healthcare professionals' perceptions of zikv. an exploratory qualitative study, based on phenomenology and grounded theory, was conducted in barcelona, spain. data were collect ...202032933007
old drugs with new tricks: efficacy of fluoroquinolones to suppress replication of flaviviruses.repurposing fda-approved compounds could provide the fastest route to alleviate the burden of disease caused by flaviviruses. in this study, three fluoroquinolones, enoxacin, difloxacin and ciprofloxacin, curtailed replication of flaviviruses zika (zikv), dengue (denv), langat (lgtv) and modoc (modv) in hek-293 cells at low micromolar concentrations. time-of-addition assays suggested that enoxacin suppressed zikv replication at an intermediate step in the virus life cycle, whereas ciprofloxacin ...202032933138
placental alkaline phosphatase promotes zika virus replication by stabilizing viral proteins through bip.zika virus (zikv) infection during pregnancy causes intrauterine growth defects and microcephaly, but knowledge of the mechanism through which zikv infects and replicates in the placenta remains elusive. here, we found that alpp, an alkaline phosphatase expressed primarily in placental tissue, promoted zikv infection in both human placental trophoblasts and astrocytoma cells. alpp bound to zikv structural and nonstructural proteins and thereby prevented their proteasome-mediated degradation and ...202032934082
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