Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| bacterial promotion of bisphosphonate-induced osteonecrosis in wistar rats. | clinically, bisphosphonate-related osteonecrosis (bron) only occurs in the jaw (bronj). we aimed to determine differences between the jaw and other bones, as well as the relationship between periodontal pathogens and bron. twelve male wistar rats were divided into two groups: group z (n=6) were subcutaneously injected with zoledronic acid weekly for 4 weeks; group c (n=6) were injected with saline. one week after the final injection, rats in both groups were divided into three subgroups: aa subg ... | 2013 | 23932020 |
| in vitro evaluation of dispersinb on methicillin-resistant staphylococcus pseudintermedius biofilm. | methicillin resistant staphylococcus pseudintermedius (mrsp) is an important canine pathogen that has been shown to produce biofilm in vitro. biofilm production may be an important virulence factor and methods to eliminate biofilm-associated infections are required. an enzyme of aggregatibacter actinomycetemcomitans, dispersinb, has been shown to degrade the extracellular matrix in the biofilm of a variety of bacteria including staphylococcus aureus and staphylococcus epidermidis. the objective ... | 2013 | 23932310 |
| a comparison of aggregatibacter actinomycetemcomitans (aa) virulence traits in a rat model for periodontal disease. | our aim was to explore the effects of cytolethal distending toxin (cdt) in a well established rat model of periodontal disease where leukotoxin (ltxa) was thought to have no known effect. in vitro studies, were used to assess cdtb activity using aa leukotoxin as a negative control. these studies showed that both cdtb and ltxa (unexpectedly) exerted significant effects on cd4(+) t cells. as a result we decided to compare the effects of these two prominent aa virulence factors on bone loss using o ... | 2013 | 23936002 |
| identification of a novel bacterial outer membrane interleukin-1β-binding protein from aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans is a gram-negative opportunistic oral pathogen. it is frequently associated with subgingival biofilms of both chronic and aggressive periodontitis, and the diseased sites of the periodontium exhibit increased levels of the proinflammatory mediator interleukin (il)-1β. some bacterial species can alter their physiological properties as a result of sensing il-1β. we have recently shown that this cytokine localizes to the cytoplasm of a. actinomycetemcomitans in ... | 2013 | 23936223 |
| aggregatibacter actinomycetemcomitans biofilm killing by a targeted ciprofloxacin prodrug. | a ph-sensitive ciprofloxacin prodrug was synthesized and targeted against biofilms of the periodontal pathogen aggregatibacter actinomycetemcomitans (aa). the dose required to reduce the viability of a mature biofilm of aa by ~80% was in the range of ng cm(-2) of colonized area (mean biofilm density 2.33 × 10(9) cells cm(-2)). a mathematical model was formulated that predicts the temporal change in the concentration of ciprofloxacin in the aa biofilm as the drug is released and diffuses into the ... | 2013 | 23952779 |
| bacterial adhesion to antibiotic-loaded guided tissue regeneration membranes - a scanning electron microscopy study. | bacterial contamination of sites undergoing guided tissue regeneration (gtr) therapy may reduce the efficiency of periodontal regeneration. this study compared bacterial adhesion onto various gtr membranes incorporated with antibiotics. | 2015 | 23969040 |
| probing bacterial metabolism during infection using high-resolution transcriptomics. | a fundamental aspect of most infectious diseases is the need for the invading microbe to proliferate in the host. however, little is known about the metabolic pathways required for pathogenic microbes to colonize and persist in their hosts. in this study, we used rna sequencing (rna-seq) to generate a high-resolution transcriptome of the opportunistic pathogen aggregatibacter actinomycetemcomitans in vivo. we identified 691 a. actinomycetemcomitans transcriptional start sites and 210 noncoding r ... | 2013 | 23974023 |
| platelet-activating factor receptor blockade ameliorates aggregatibacter actinomycetemcomitans-induced periodontal disease in mice. | periodontal disease (pd) is a chronic inflammatory and alveolar bone destructive disease triggered by oral biofilm-producing microorganisms, such as aggregatibacter actinomycetemcomitans. the levels of the phospholipid platelet-activating factor (paf) in the saliva, gingival crevicular fluid, and periodontal tissues are significantly increased during inflammatory conditions, such as pd, but the exact mechanism that links paf to alveolar bone resorption is not well understood. in the current stud ... | 2013 | 24002061 |
| cardiobacterium hominis-induced acute dacryocystitis and lacrimal abscess. | cardiobacterium hominis is a member of the hacek (haemophilus sp., actinobacillus actinomycetemcomitans, c. hominis, eikenella corrodens, and kingella kingae) group commonly associated with endocarditits and is normally present in the respiratory tract. we describe the first case of acute dacryocystitis with lacrimal abscess caused by c. hominis along with a brief review of the literature. the patient responded to oral and topical ciprofloxacin after incision and drainage and awaits dacryocystor ... | 2014 | 24008805 |
| detection of putative periodontopathic bacteria in type 1 diabetic and healthy children: a comparative study. | the aim of this study was to compare and assess the risk of periodontitis due to the presence of four putative periodontopathic bacteria (porphyromonas gingivalis, treponema denticola, tannerella forsythia, and aggregatibacter actinomycetemcomitans) in type 1 diabetic and healthy children. | 2013 | 24025882 |
| distribution of biotypes and leukotoxic activity of aggregatibacter actinomycetemcomitans isolated from brazilian patients with chronic periodontitis. | aggregatibacter actinomycetemcomitans is an important etiologic agent of the periodontitis and is associated with extra-oral infections. in this study, the detection of the ltxa gene as well as the ltx promoter region from leukotoxic a. actinomycetemcomitans isolated from 50 brazilian patients with periodontitis and 50 healthy subjects was performed. the leukotoxic activity on hl-60 cells was also evaluated. leukotoxic activity was determined using a trypan blue exclusion method. the 530 bp dele ... | 2008 | 24031284 |
| aggregatibacter actinomycetemcomitans arcb influences hydrophobic properties, biofilm formation and adhesion to hydroxyapatite. | the regulation of gene expression in the oral pathogen aggregatibacter actinomycetemcomitans is still not fully elucidated. arcab is a two-component system which allows facultative anaerobic bacteria to sense various respiratory growth conditions and adapt their gene expression accordingly.this study investigated in a. actinomycetemcomitans the role of arcb on the regulation of biofilm formation, adhesion to saliva coated hydroxyapatite (sha) and the hydrophobic properties of the cell. these phe ... | 2009 | 24031399 |
| occurrence of periodontal pathogens among patients with chronic periodontitis. | the aim of the present study was to evaluate the presence of the periodontal pathogens that form the red complex (tannerella forsythia, porphyromonas gingivalis and treponema denticola) and aggregatibacter actinomycetemcomitans in patients with chronic periodontitis. the sample consisted of 29 patients with a clinical and radiographic diagnosis of chronic periodontitis based on the criteria of the american academy of periodontology (3). samples for microbiological analysis were collected from th ... | 2012 | 24031906 |
| role and regulation of the flp/tad pilus in the virulence of pectobacterium atrosepticum scri1043 and pectobacterium wasabiae scc3193. | in this study, we characterized a putative flp/tad pilus-encoding gene cluster, and we examined its regulation at the transcriptional level and its role in the virulence of potato pathogenic enterobacteria of the genus pectobacterium. the flp/tad pilus-encoding gene clusters in pectobacterium atrosepticum, pectobacterium wasabiae and pectobacterium aroidearum were compared to previously characterized flp/tad gene clusters, including that of the well-studied flp/tad pilus model organism aggregati ... | 2013 | 24040039 |
| quantitative analysis of periodontal pathogens present in the saliva of geriatric subjects. | at present, information regarding periodontal disease in geriatric patients is scarce. the purpose of this study was to quantify the periodontal pathogens present in the saliva of korean geriatric patients and assess the relationship between the bacterial levels and the periodontal condition. | 2013 | 24040571 |
| biomarkers of periodontitis and inflammation in ischemic stroke: a case-control study. | periodontitis is a common infectious disease associated with increased risk for ischemic stroke though presently unclear mechanisms. in a case-control study, we investigated salivary levels of four periodontal pathogens, as well as systemic and local inflammatory markers. the population comprised 98 patients with acute ischemic stroke (mean ± sd, 68.2 ± 9.7 yrs; 45.9% women) and 100 healthy controls (69.1 ± 5.2 yrs; 47.0% women). patients were more often edentulous and had fewer teeth than contr ... | 2014 | 24045341 |
| molecular detection of aggregatibacter actinomycetemcomitans and porphyromonas gingivalis in subgingival plaque of healthy young children. | the aim of the present study was to evaluate the presence of aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) and porphyromonas gingivalis (p. gingivalis) in subgingival plaque of healthy young children aged between 3 and 15 years using polymerase chain reaction (pcr) and to compare their presence in children in their primary, mixed and permanent dentitions. | 2013 | 24046982 |
| salivary detection of periodontopathic bacteria in fanconi's anemia patients. | fanconi's anemia (fa) is characterized by bone marrow failure and can lead to infections such as periodontal disease. the aim of this study was to compare the prevalence of four periodontopathic bacteria including aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, fusobacterium nucleatum and treponema denticola in saliva samples from children with and without fa. paraffin-stimulated saliva samples were collected from 71 children and adolescents, aged 6-18 years old. the samples wer ... | 2013 | 24055631 |
| comparing the efficacy of hyper-pure chlorine-dioxide with other oral antiseptics on oral pathogen microorganisms and biofilm in vitro. | this study examines the antibacterial properties of sodium hypochlorite (naocl), chlorhexidine gluconate (chx), listerine®, and high purity chlorine dioxide (solumium, clo2) on selected common oral pathogen microorganisms and on dental biofilm in vitro. antimicrobial activity of oral antiseptics was compared to the gold standard phenol. we investigated streptococcus mutans, lactobacillus acidophilus, enterococcus faecalis, veillonella alcalescens, eikenella corrodens, actinobacillus actinomycete ... | 2013 | 24060558 |
| micrornas responsive to aggregatibacter actinomycetemcomitans and porphyromonas gingivalis lps modulate expression of genes regulating innate immunity in human macrophages. | micrornas (mirnas) are a class of small, noncoding rnas that regulate post-transcriptional expression of their respective target genes and are responsive to various stimuli, including lps. here we examined the early (4 h) mirna responses of thp1-differentiated macrophages challenged with lps derived from the periodontal pathogens, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis or environmentally-modified lps obtained from p. gingivalis grown in cigarette smoke extract. predicted ... | 2014 | 24062196 |
| anti-inflammatory and wound healing potential of citrus auraptene. | auraptene is the most abundant naturally occurring geranyloxycoumarin. it is primarily isolated from plants in the rutaceae family, many of which, like citrus fruits, are used as food in many countries. auraptene is a biologically active secondary metabolite with valuable properties. the aim of our study was to identify novel properties of auraptene with potential for managing periodontal diseases, an inflammatory disease of bacterial origin affecting the tissues surrounding and supporting the t ... | 2013 | 24070132 |
| antimicrobial activity of isothiocyanates (itcs) extracted from horseradish (armoracia rusticana) root against oral microorganisms. | the antimicrobial activity of isothiocyanates (itcs) extracted from horseradish root was investigated against oral microorganisms: 6 strains of facultative anaerobic bacteria, streptococcus mutans, streptococcus sobrinus, lactobacillus casei, staphylococcus aureus, enterococcus faecalis and aggregatibacter actinomycetemcomitans; one strain of yeast, candida albicans, and 3 strains of anaerobic bacteria, fusobacterium nucleatum, prevotella nigrescens, and clostridium perfringens. the itcs extract ... | 2013 | 24077540 |
| a comparative study of antimicrobial activity of proroot mta, root mta, and portland cement on actinobacillus actinomycetemcomitans. | the purpose of our study was to evaluate the antibacterial effect of proroot mta (prmta), root mta (rmta) and portland cement (pc) at their clinical concentration (70 mg/25 µl) against actinobacillus actinomycetemcomitans (aa) one of the prominent periodontal (pocket) microorganisms. | 2008 | 24082905 |
| microarray analysis of microbiota of gingival lesions in noma patients. | noma (cancrum oris) is a gangrenous disease of unknown etiology affecting the maxillo-facial region of young children in extremely limited resource countries. in an attempt to better understand the microbiological events occurring during this disease, we used phylogenetic and low-density microarrays targeting the 16s rrna gene to characterize the gingival flora of acute noma and acute necrotizing gingivitis (ang) lesions, and compared them to healthy control subjects of the same geographical and ... | 2013 | 24086784 |
| oral community interactions of filifactor alocis in vitro. | filifactor alocis is a gram positive anaerobe that is emerging as an important periodontal pathogen. in the oral cavity f. alocis colonizes polymicrobial biofilm communities; however, little is known regarding the nature of the interactions between f. alocis and other oral biofilm bacteria. here we investigate the community interactions of two strains of f. alocis with streptococcus gordonii, fusobacterium nucleatum, porphyromonas gingivalis and aggregatibacter actinomycetemcomitans, organisms w ... | 2013 | 24098460 |
| bacterial infection increases periodontal bone loss in diabetic rats through enhanced apoptosis. | periodontal disease is the most common osteolytic disease in humans and is significantly increased by diabetes mellitus. we tested the hypothesis that bacterial infection induces bone loss in diabetic animals through a mechanism that involves enhanced apoptosis. type ii diabetic rats were inoculated with aggregatibacter actinomycetemcomitans and treated with a caspase-3 inhibitor, zdevd-fmk, or vehicle alone. apoptotic cells were measured with tunel; osteoblasts and bone area were measured in h& ... | 2013 | 24113454 |
| simvastatin inhibits lipopolysaccharide-induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease. | statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase and have anti-inflammatory effects independent of cholesterol lowering. recent clinical studies have indicated that statin intake has a beneficial effect on periodontal disease. however, the underlying mechanisms have not been well understood. in the current study, we employed a rat model with lipopolysaccharide (lps)-induced periodontal disease and determined the effect of simvastatin, a commonly prescribed statin, on ost ... | 2014 | 24117880 |
| determination of periodontopathogens in patients with cri du chat syndrome. | cri du chat syndrome is a genetic alteration associated with some oral pathologies. however, it has not been described previously any clinical relationship between the periodontal disease and the syndrome. the purpose of this comparative study was to compare periodontopathogenic flora in a group with cri du chat syndrome and another without the síndrome, to assess a potential microbiological predisposition to suffer a periodontitis. | 2013 | 24121919 |
| the effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein e-deficient mice. | chronic infections have been demonstrated to maintain low-grade systemic inflammation and associate with atherosclerosis. we studied the inflammation- and lipid homeostasis-related effects of aggregatibacter actinomycetemcomitans (aa) and chlamydia pneumoniae (cpn) infections on the epididymal and inguinal adipose tissue (at) transcriptomes and fatty acid distribution in apolipoprotein (apo) e-deficient mice. chow-fed apoe-deficient mice were exposed to 1) chronic intranasal infection with c. pn ... | 2013 | 24131481 |
| does photodynamic therapy enhance standard antibacterial therapy in dentistry? | the aim of this study was to assess whether or not photodynamic therapy enhanced standard antibacterial therapy in dentistry. | 2013 | 24138192 |
| microbial analysis of subgingival plaque samples compared to that of whole saliva in patients with periodontitis. | the detection of special bacterial species in patients with periodontitis is considered to be useful for clinical diagnosis and treatment. the collection of subgingival plaque samples is the common way for the determination of periodontopathic bacteria. however, recently, salivary analysis has been discussed as an advantageous future diagnostic method for periodontitis because it offers simple quantitative sampling and the possibility to assess various bacteria. the aim of this cross-sectional s ... | 2014 | 24144271 |
| differential transcription of virulence genes in aggregatibacter actinomycetemcomitans serotypes. | aggregatibacter actinomycetemcomitans serotypes are clearly associated with periodontitis or health, which suggests distinct strategies for survival within the host. | 2013 | 24159369 |
| antimicrobial photodynamic efficiency of novel cationic porphyrins towards periodontal gram-positive and gram-negative pathogenic bacteria. | the gram-negative aggregatibacter actinomycetemcomitans and fusobacterium nucleatum are major causative agents of aggressive periodontal disease. due to increase in the number of antibiotic-resistant bacteria, antimicrobial photodynamic therapy (apdt) seems to be a plausible alternative. in this work, photosensitization was performed on gram-positive and gram-negative bacteria in pure culture using new-age cationic porphyrins, namely mesoimidazolium-substituted porphyrin derivative (imp) and pyr ... | 2014 | 24164211 |
| acquisition of oral microbes and associated systemic responses of newborn nonhuman primates. | the acquisition and development of the complex oral microbiome remain ill defined. while selected species of oral bacteria have been examined in relation to their initial colonization in neonates, a more detailed understanding of the dynamics of the microbiome has been developed only in adults. the current investigation used a nonhuman primate model to document the kinetics of colonization of the oral cavities of newborns and infants by a range of oral commensals and pathogens. differences in co ... | 2014 | 24173024 |
| effect of controlled-release periochip™ on clinical and microbiological parameters in patients of chronic periodontitis. | the aim of the present study was to evaluate and compare the clinical and microbiological effectiveness of periochip™ as an adjunct to scaling and root planing (srp) with srp alone in patients with chronic periodontitis. | 2013 | 24174754 |
| microbial composition of atherosclerotic plaques. | the association of infections such as periodontitis with atherosclerotic diseases is well documented. in spite of the high diversity of the human oral microbiota, and its close contact with the circulatory system, few oral species were detected in atherosclerotic plaques. thus, we attempted to evaluate the microbial diversity of atherosclerotic plaques from patients with different periodontal conditions, submitted to endarterectomy by a broad-range microbial method. | 2014 | 24188425 |
| protective effects of human lactoferrin during aggregatibacter actinomycetemcomitans-induced bacteremia in lactoferrin-deficient mice. | aggregatibacter actinomycetemcomitans, a periodontopathogen, has been associated with several systemic diseases. herein, we report the protective effect of human lactoferrin (hlf) during a. actinomycetemcomitans bacteremia in lactoferrin knockout (lfko(-/-)) mice. the prophylactic, concurrent, and therapeutic intravenous (i.v.) administrations of hlf significantly cleared the bacteria from blood and organs. nevertheless, all modes of hlf administration significantly decreased the concentrations ... | 2014 | 24189260 |
| leukotoxin kills rodent wbc by targeting leukocyte function associated antigen 1. | leukotoxin is a protein that is secreted by aggregatibacter actinomycetemcomitans and that primarily targets the active form of leukocyte function associated antigen 1 (lfa1) on wbc. because of its specificity for wbc, leukotoxin is being developed as a novel biologic treatment for hematologic malignancies and autoimmune-inflammatory diseases. early studies indicated that leukotoxin is specific for wbc from humans and old world primates. in the current study, we used in vivo and in vitro assays ... | 2013 | 24209968 |
| leukotoxicity of aggregatibacter actinomycetemcomitans in generalized aggressive periodontitis in brazilians and their family members. | the purpose of this study was to examine the leukotoxin promoter types of aggregatibacter actinomycetemcomitans clones in subjects with generalized aggressive periodontitis (gagp) and in their family members (fm). | 2015 | 24212989 |
| antibacterial activity of moxifloxacin on bacteria associated with periodontitis within a biofilm. | the activity of moxifloxacin was compared with ofloxacin and doxycycline against bacteria associated with periodontitis within a biofilm (single strain and mixed population) in vitro. mics and minimal bactericidal concentrations (mbcs) of moxifloxacin, ofloxacin and doxycyline were determined against single strains and mixed populations in a planktonic state. single-species biofilms of two porphyromonas gingivalis and two aggregatibacter actinomycetemcomitans strains and a multispecies biofilm c ... | 2014 | 24217128 |
| anabolic steroids affect human periodontal health and microbiota. | this study aims to evaluate periodontal microbiological differences between systemically healthy nonsmoker males taking anabolic androgenic steroids (aass) and non-aas users and to find associations between disease severity and aas use. | 2014 | 24221579 |
| anaerobic co-culture of mesenchymal stem cells and anaerobic pathogens - a new in vitro model system. | human mesenchymal stem cells (hmscs) are multipotent by nature and are originally isolated from bone marrow. in light of a future application of hmscs in the oral cavity, a body compartment with varying oxygen partial pressures and an omnipresence of different bacterial species i.e. periodontitis pathogens, we performed this study to gain information about the behavior of hmsc in an anaerobic system and the response in interaction with oral bacterial pathogens. | 2013 | 24223777 |
| quercetin inhibits inflammatory bone resorption in a mouse periodontitis model. | periodontitis is a disease that leads to bone destruction and represents the main cause of tooth loss in adults. the development of aggressive periodontitis has been associated with increased inflammatory response that is induced by the presence of a subgingival biofilm containing aggregatibacter actinomycetemcomitans. the flavonoid quercetin (1) is widespread in vegetables and fruits and exhibits many biological properties for possible medical and clinical applications such as its anti-inflamat ... | 2013 | 24246038 |
| does microwave sterilization of growth media involve any non-thermal effect? | fast reactions mediated by microwaves are often attributed by many to non-thermal effect. we show here that rapid formation of maillard reaction products during microwave sterilization of growth medium results from concentration effect and not any non-thermal effect. this leads to an improved method for microwave sterilization of growth media. | 2014 | 24246231 |
| serotype-dependent response of human dendritic cells stimulated with aggregatibacter actinomycetemcomitans. | different serotypes of aggregatibacter actinomycetemcomitans have been described based on the lipopolysaccharide (lps)-o-polysaccharide antigenicity. in turn, a distinct effect of a. actinomycetemcomitans serotypes has been described on cell proliferation and pro-inflammatory cytokine production in different human cells. this study was aimed to investigate the differential dendritic cell (dc) response when stimulated with different bacterial strains belonging to the most prevalent serotypes of a ... | 2014 | 24256118 |
| high incidence of aggregatibacter actinomycetemcomitans infection in patients with cerebral infarction and diabetic renal failure: a cross-sectional study. | recent epidemiological studies suggest that periodontitis is a major risk factor for renal failure and cerebral infarction. the aim of this study was to evaluate the association among periodontitis, renal failure, and cerebral infarction, focusing on microbiological and immunological features. | 2013 | 24267704 |
| in vitro evaluation of the risk of inducing bacterial resistance to disinfection treatment with photolysis of hydrogen peroxide. | the purpose of the present study was to evaluate the risk of inducing bacterial resistance to disinfection treatment with photolysis of h2o2 and comparing this with existing antibacterial agents. we tested seven antibacterial agents, including amoxicillin, cefepime hydrochloride, erythromycin, ofloxacin, clindamycin hydrochloride, ciprofloxacin hydrochloride, and minocycline hydrochloride, as positive controls for validation of the assay protocol. for all of the agents tested, at least one of th ... | 2013 | 24282582 |
| blue light kills aggregatibacter actinomycetemcomitans due to its endogenous photosensitizers. | the aim of this study was to demonstrate that the periodontal pathogen aggregatibacter actinomycetemcomitans (aa) can be killed by irradiation with blue light derived from a led light-curing unit due to its endogenous photosensitizers. | 2014 | 24297656 |
| effects of areca nut extracts on phagocytosis of actinobacillus actinomycete mcomitans atcc 33384 by neutrophils in patients with chronic periondontitis. | a higher prevalence of periodontal disease among areca nut chewers than non chewers has been demonstrated. neutrophils, the first line of defence mechanism against microbial infection play an important role in maintaining the periodontal health. in this context our aim was to evaluate the effects of areca nut extracts on phagocytic activity by neutrophils isolated from gingival crevicular washing of healthy subjects and patients with chronic periodontitis. | 2013 | 24298462 |
| progression of attachment loss is strongly associated with presence of the jp2 genotype of aggregatibacter actinomycetemcomitans: a prospective cohort study of a young adolescent population. | to assess the progression of attachment loss (al) during a 2-year period according to the presence of jp2 and non-jp2 genotypes of aggregatibacter actinomycetemcomitans in a ghanaian adolescent population. | 2014 | 24304011 |
| the periodontal pathogen aggregatibacter actinomycetemcomitans affects experimental autoimmune myocarditis in mice. | recent reports assert that dental health is linked to an increased risk of cardiovascular disease. it is well known that aggregatibacter actinomycetemcomitans (a.a.) is highly associated with heart disease. indeed, we previously reported that a.a. affects the development of heart disease in a mouse model. however, no reports have clarified the relationship between a.a. and experimental autoimmune myocarditis (eam). the aim of this study was to investigate the effects of a.a. on eam in mice. eam ... | 2013 | 24309453 |
| serotypes of aggregatibacter actinomycetemcomitans in relation to periodontal status and geographic origin of individuals-a review of the literature. | several studies have focused on the relationship among serotype distribution, ethnical status and geographic populations, and periodontal conditions. studies that have investigated the prevalence and the distribution of a. actinomycetemcomitans serotypes and the relation between the different serotypes of the bacterium and periodontal status were reviewed. | 2014 | 24316700 |
| biology and pathogenesis of cytomegalovirus in periodontal disease. | human periodontitis is associated with a wide range of bacteria and viruses and with complex innate and adaptive immune responses. porphyromonas gingivalis, tannerella forsythia, aggregatibacter actinomycetemcomitans, treponema denticola, cytomegalovirus and other herpesviruses are major suspected pathogens of periodontitis, and a combined herpesvirus-bacterial periodontal infection can potentially explain major clinical features of the disease. cytomegalovirus infects periodontal macrophages an ... | 2014 | 24320955 |
| dental caries and microbiota in children with black stain and non-discoloured dental plaque. | we aimed to assess caries experience and microbiota in systemically healthy children with black stain (bs) and non-discoloured plaque. | 2014 | 24335143 |
| simvastatin inhibits lps-induced alveolar bone loss during metabolic syndrome. | studies in recent years have shown a positive relationship between metabolic syndrome (ms) and periodontal disease (pd). given that patients with ms take statins to reduce cholesterol, and statins also have anti-inflammatory effects, it is important to determine if statin intake hinders the progression of ms-associated pd. in this study, pd was induced in zucker fat rats (zfrs), an animal model for ms, and in control lean rats by periodontal injection of aggregatibacter actinomycetemcomitans lip ... | 2014 | 24352501 |
| periodontal bacteria in the genital tract: are they related to adverse pregnancy outcome? | one of the most important factors implicated in preterm birth (ptb) is acute genitourinary tract infection. the bacteria causing chronic periodontal inflammation include gram-negative rods and anaerobes similar to those found in women with bacterial vaginosis. the aim of this prospective study is to investigate the relationship between oral and vaginal microflora and preterm low birth weight. real-time polymerase chain reaction was used to detect both the presence and level of six periodontitis- ... | 2017 | 24355228 |
| correlation of aggregatibacter actinomycetemcomitans detection with clinical/immunoinflammatory profile of localized aggressive periodontitis using a 16s rrna microarray method: a cross-sectional study. | the objective of this study was to determine whether the detection of aggregatibacter actinomycetemcomitans (aa) correlates with the clinical and immunoinflammatory profile of localized aggressive periodontitis (lap), as determined by by 16s rrna gene-based microarray. | 2013 | 24376864 |
| [aggregatibacter actinomycetemcomitans and porphyromonas gingivalis in aggressive periodontitis in morocco -- preliminary study]. | the microbial eatiology of aggressive perodontitis is different worldwidly. the purpose of this study was to determine the presence or absence of two anaerobic, highly pathogenic bacteria, aggregatibacter actinomycetemcomitans and porphyromonas gingivalis (p.g) in aggressive periodontitis in a moroccan population. | 2013 | 24380115 |
| serum c-reactive protein and immunoglobulin g antibodies to periodontal pathogens may be effect modifiers of periodontitis and hyperglycemia. | serum c-reactive protein (crp) is elevated in both periodontitis and type 2 diabetes mellitus through inflammation. aggregatibacter actinomycetemcomitans and porphyromonas gingivalis have been found in periodontal pockets in patients with diabetes. this study examines effect modification by examining the extent to which the associations between periodontitis and hyperglycemia were different by levels of serum crp and periodontal pathogens. | 2014 | 24410292 |
| comparison of the penetration and passage of streptococcus mutans and aggregatibacter actinomycetemcomitans through membranes loaded with tetracycline, amoxicillin, and chlorhexidine: an in vitro study. | this study aimed at comparing the colonization and passage of streptococcus mutans and aggregatibacter actinomycetemcomitans (aa) through polytetrafluoroethylene (ptfe) and acellular dermal matrix (adm) membranes loaded with tetracycline, amoxicillin, and chlorhexidine. | 2014 | 24423468 |
| permanent pacemaker-associated actinomycetemcomitans endocarditis: a case report. | aggregatibacter actinomycetemcomitans is a gram-negative bacillus, member of the hacek group of bacteria, and it is a very rare cause of endocarditis. it is also an extremely rare cause of device-associated infection of the heart. we describe the case of a 25 year-old man who presented with pacemaker-associated endocarditis due to aggregatibacter actinomycetemcomitans and also discuss the implications and treatment of this organism. | 2013 | 24432293 |
| the pga gene cluster in aggregatibacter actinomycetemcomitans is necessary for the development of natural competence in ca(2+) -promoted biofilms. | natural competence is the ability of bacteria to incorporate extracellular dna into their genomes. this competence is affected by a number of factors, including ca(2+) utilization and biofilm formation. as bacteria can form thick biofilms in the presence of extracellular ca(2+) , the additive effects of ca(2+) -promoted biofilm formation on natural competence should be examined. we evaluated natural competence in aggregatibacter actinomycetemcomitans, an important periodontal pathogen, in the co ... | 2014 | 24450419 |
| in vivo effectiveness of silicone gel sheets as barriers at the inner microgap between a prosthetic abutment and an external-hexagon implant platform. | bacterial penetration and colonization of the microgap at the implant-abutment interface have been reported in several studies. the aim of this study was to evaluate the effectiveness of placing a silicone membrane between the abutment and the implant platform in an attempt to seal the interface. | 2014 | 24451862 |
| a case of aggregatibacter actinomycetemcomitans endocarditis presenting as quadriceps myositis. | an 80 year old female was admitted with an eight week history of fever associated with painful swelling of her right thigh, and a long history of poor dentition. culture of blood stained fluid aspirated from the abscess grew aggregatibacter actinomycetemcomitans (aa) sensitive to ampicillin and cephalosporins. transoesophageal echocardiography indicated endocarditis. four weeks treatment with intravenous ceftriaxone and appropriate dental care was followed by full recovery. | 2012 | 24470921 |
| a pediatric case of cardiobacterium hominis endocarditis. | gram negative endocarditis is relatively rare in pediatrics but when they occur they are most frequently caused by one of the hacek (haemophilus species, actinobacillus actinomycetemcomitans, c. hominis, eikenella corrodens and kingella kingae) group of microorganisms. within the hacek group of microorganisms there have been approximately 100 cases of cardiobacterium hominis endocarditis reported in the literature, but only 2 previous cases of endocarditis and one case of pericarditis have been ... | 2013 | 24470958 |
| photodynamic antimicrobial effect of safranine o on an ex vivo periodontal biofilm. | the increasing resistance of oral pathogens against antibiotic measures urgently requires new therapeutic strategies. in this context, antimicrobial photodynamic therapy (apdt) may play a crucial part in the future. the aim of the present study was to compare the antibacterial efficiency of apdt using the photosensitizer safranine o with that of chlorhexidine (0.2% chx) on an ex vivo biofilm. | 2014 | 24473989 |
| in vitro-activity of oily calcium hydroxide suspension on microorganisms as well as on human alveolar osteoblasts and periodontal ligament fibroblasts. | findings from animal and human studies have indicated that an oily calcium hydroxide suspension (ochs) may improve early wound healing in the treatment of periodontitis. calcium hydroxide as the main component is well known for its antimicrobial activity, however at present the effect of ochs on the influence of periodontal wound healing/regeneration is still very limited. the purpose of this in vitro study was to investigate the effect of ochs on periodontopathogenic bacteria as well as on the ... | 2014 | 24475753 |
| 16s rdna-based metagenomic analysis of dental plaque and lung bacteria in patients with severe acute exacerbations of chronic obstructive pulmonary disease. | acute exacerbations of chronic obstructive pulmonary disease (ae-copd) are leading causes of mortality in hospital intensive care units. we sought to determine whether dental plaque biofilms might harbor pathogenic bacteria that can eventually cause lung infections in patients with severe ae-copd. | 2014 | 24484531 |
| cyclodextrin modulates the cytotoxic effects of chlorhexidine on microrganisms and cells in vitro. | although several studies have shown that chlorhexidine (cx) has bactericidal activity and exerts toxic effects on periodontal tissues a few studies evaluated mechanisms to reduce its adverse effects maintaining the antimicrobial properties. therefore, the aim of the present study was to investigate the in vitro antimicrobial activity and cellular cytotoxicity of cx included on cyclodextrins (cd), α, β or hp-β-cyclodextrins (hp-β-cd). the influence of cds was determined by increasing its molar ra ... | 2015 | 24491181 |
| effects of acidic sodium fluoride-treated, commercially pure titanium on periodontal pathogens and rat bone marrow cells. | the purpose of the present study was to clarify the potentiality of acidic fluoride solution in treating peri-implantitis. we examined bactericidal activity of fluoride solution against periodontal pathogens; and evaluated the effects of fluoride on titanium, and the effects on cell proliferation and differentiation of rat bone marrow cells on the fluoride-treated titanium. aggregatibacter actinomycetemcomitans and porphyromonas gingivalis were used to determine minimal inhibitory concentration ... | 2014 | 24492115 |
| quantification of periodontal pathogens in vascular, blood, and subgingival samples from patients with peripheral arterial disease or abdominal aortic aneurysms. | the aim of this investigation is to quantify periodontal pathogens (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, campylobacter rectus, and tannerella forsythia) in vascular, blood, and subgingival samples. as a secondary objective, two molecular bacterial identification methods (nested polymerase chain reaction [pcr] and quantitative pcr [qpcr]) are compared. | 2014 | 24502612 |
| a markerless protocol for genetic analysis of aggregatibacter actinomycetemcomitans. | the genomes of different aggregatibacter actinomycetemcomitans (a actinomycetemcomitans) strains contain many strain-specific genes and genomic islands (defined as dna found in some but not all strains) of unknown functions. genetic analysis for the functions of these islands will be constrained by the limited availability of genetic markers and vectors for a actinomycetemcomitans. in this study, we tested a novel genetic approach of gene deletion and restoration in a naturally competent a actin ... | 2014 | 24530245 |
| differential transcriptional regulation of aggregatibacter actinomycetemcomitans lsracdbfg and lsrrk operons by integration host factor protein. | we previously showed that the aggregatibacter actinomycetemcomitans lsracdbfg and lsrrk operons are regulated by lsrr and cyclic amp receptor protein (crp) and that proper regulation of the lsr locus is required for optimal biofilm growth by a. actinomycetemcomitans. here, we identified sequences that reside immediately upstream from both the lsra and lsrr start codons that closely resemble the consensus recognition sequence of escherichia coli integration host factor (ihf) protein. a. actinomyc ... | 2014 | 24532769 |
| biodegradable nanofibrous drug delivery systems: effects of metronidazole and ciprofloxacin on periodontopathogens and commensal oral bacteria. | the purposes of this study were to fabricate biodegradable polydioxanone (pds ii®) electrospun periodontal drug delivery systems (hereafter referred to as matrices) containing either metronidazole (met) or ciprofloxacin (cip) and to investigate the effects of antibiotic incorporation on both periodontopathogens and commensal oral bacteria. | 2014 | 24535074 |
| the cytolethal distending toxin of aggregatibacter actinomycetemcomitans inhibits macrophage phagocytosis and subverts cytokine production. | aggregatibacter actinomycetemcomitans is an important periodontal pathogen that can participate in periodontitis and other non-oral infections. the cytolethal distending toxin (cdt) is among the virulence factors produced by this bacterium. the cdt is also secreted by several mucosa-associated gram-negative pathogens and may play a role in perpetuating the infection by modulating the immune response. although the toxin targets a wide range of eukaryotic cell types little is known about its activ ... | 2014 | 24548424 |
| subgingival plaque sampling after combined mechanical and antibiotic nonsurgical periodontal therapy. | this study aimed to make a comparison of two sampling strategies of subgingival plaque after combined mechanical-antibiotic periodontal therapy. | 2015 | 24554003 |
| application of a diode laser in the reduction of targeted periodontal pathogens. | periodontal disease belongs to a group of diseases with more than one cause, it is a disease of a multifactorial etiology. although bacteria are the main cause of the disease, immunoinflammatory reaction of the host is responsible for the majority of destructive changes in periodontal tissue. the main issue in the evaluation of the success of periodontal therapy is the pluralism of the bacteria and their dynamic changes during the duration, on the one hand, and the possible inaccuracy of classic ... | 2013 | 24554796 |
| prevelance of periodontopathogenic bacteria in subgingival biofilm and atherosclerotic plaques of patients undergoing coronary revascularization surgery. | the objective of the present study was to detect the presence of specific periodontopathogenic bacteria in the coronary plaque of patients with coronary artery disease and to find out the significant association between the periodontal status and the presence of pathogenic bacteria in the coronary plaque. | 2013 | 24554879 |
| prevalence of periodontitis among the adolescents aged 15-18 years in mangalore city: an epidemiological and microbiological study. | periodontitis is a group of inflammatory diseases affecting the supporting tissues of the tooth. both aggressive periodontitis (ap) and chronic periodontitis (cp) have a multifactorial etiology, with dental plaque as the initiating factor. however, the initiation and progression of periodontitis are influenced by other factors including microbiologic, social and behavioral and systemic and genetic factors. the prevalence of periodontal diseases varies in different regions of the world according ... | 2013 | 24554891 |
| [dissertations 25 years after date 37. susceptibility to periodontal diseases]. | in the eighties of the former century it was observed that individuals had different modes of development of periodontitis, largely for unknown reasons. it was assumed that periodontal disease developed as a result of the presence of virulent micro-organisms in combination with an inadequate host response. the concept of this (im)balance in host parasite interactions developed further, in part because of new research techniques. with respect to oral bacteria it was shown that periodontal pathoge ... | 2013 | 24555252 |
| photodynamic therapy during supportive periodontal care: clinical, microbiologic, immunoinflammatory, and patient-centered performance in a split-mouth randomized clinical trial. | this study investigates the effect of photodynamic therapy (pdt) as monotherapy during supportive periodontal therapy. | 2014 | 24555751 |
| a gene cluster for the synthesis of serotype g-specific polysaccharide antigen in aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans is an important pathogen related to aggressively progressive periodontal breakdown in adolescents and adults. the species can be divided into six serotypes (a-f) according to their surface carbohydrate antigens. recently, a new serotype g of a. actinomycetemcomitans was proposed. the aim of the present study was to sequence the gene cluster associated with the biosynthesis of the serotype g-specific polysaccharide antigen and develop serotype-specific primer ... | 2014 | 24562973 |
| diverse toll-like receptors mediate cytokine production by fusobacterium nucleatum and aggregatibacter actinomycetemcomitans in macrophages. | toll-like receptors (tlrs) orchestrate a repertoire of immune responses in macrophages against various pathogens. fusobacterium nucleatum and aggregatibacter actinomycetemcomitans are two important periodontal pathogens. in the present study, we investigated tlr signaling regulating cytokine production of macrophages in response to f. nucleatum and a. actinomycetemcomitans. tlr2 and tlr4 are redundant in the production of cytokines (interleukin-6 [il-6] and tumor necrosis factor alpha [tnf-α]) i ... | 2014 | 24566622 |
| inflammatory bone loss in experimental periodontitis induced by aggregatibacter actinomycetemcomitans in interleukin-1 receptor antagonist knockout mice. | the interleukin-1 receptor antagonist (il-1ra) binds to il-1 receptors and inhibits il-1 activity. however, it is not clear whether il-1ra plays a protective role in periodontal disease. this study was undertaken to compare experimental periodontitis induced by aggregatibacter actinomycetemcomitans in il-1ra knockout (ko) mice and wild-type (wt) mice. computed tomography (ct) analysis and hematoxylin-and-eosin (h&e) and tartrate-resistant acid phosphatase (trap) staining were performed. in addit ... | 2014 | 24566623 |
| clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. | the aim of the present study was to evaluate the clinical and microbiological effect of systemic levofloxacin (lfx) as an adjunct to scaling and root planing (srp) in patients with chronic periodontitis (cp). | 2015 | 24574052 |
| peri-implant response and microflora in organ transplant patients 1 year after prosthetic loading: a prospective controlled study. | a recent study conducted in humans demonstrated for the first time that bone loss in the immediate period after implant insertion before loading did not significantly differ in organ transplant recipients with respect to normal subjects. | 2015 | 24612063 |
| bacterial leakage in morse cone internal connection implants using different torque values: an in vitro study. | the aim of this study was to assess whether there was a decrease of bacterial leakage with increasing torque values in conical morse cone connection implants. | 2014 | 24637526 |
| sialic acid residues are essential for cell lysis mediated by leukotoxin from aggregatibacter actinomycetemcomitans. | leukotoxin (ltxa) from aggregatibacter actinomycetemcomitans is known to target and lyse β2-integrin-expressing cells such as polymorphonuclear leukocytes and macrophages. ltxa is an important virulence factor that facilitates chronic inflammation and is strongly associated with a fast-progressing form of periodontitis caused by the jp2 clone of the bacterium. here, we show that sialic acid residues are important for ltxa-induced cell lysis, regardless of whether the cell express β2-integrin or ... | 2014 | 24643533 |
| porphyromonas gingivalis gingipain is involved in the detachment and aggregation of aggregatibacter actinomycetemcomitans biofilm. | porphyromonas gingivalis and aggregatibacter actinomycetemcomitans are major periodontal pathogens that cause several types of periodontal disease. our previous study suggested that p. gingivalis gingipains secreted in the subgingival environment are related to the detachment of a.actinomycetemcomitans biofilms. however, it remains unclear whether arginine-specific cysteine proteinase (rgp) and lysine-specific proteinase (kgp) play different roles in the detachment of a. actinomycetemcomitans bi ... | 2014 | 24661327 |
| intracranial abscess secondary to dental infection. | we report a case of aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) bacteraemia and secondary brain abscess in a patient where periodontal disease was implicated as the probable source. | 2014 | 24665546 |
| microbiological assessment of the implant-abutment interface in different connections: cross-sectional study after 5 years of functional loading. | to evaluate the bacterial microflora present inside the implant connection and in the peri-implant sulcus fluid of healthy implants, and to analyze the relationships between these harboring sites for four different implant systems after at least 5 years of functional loading. | 2015 | 24665919 |
| metronidazole and amoxicillin susceptibility of aggregatibacter actinomycetemcomitans. | 2014 | 24674865 | |
| association between hacek bacteraemia and endocarditis. | we retrospectively examined medical records of 87 patients with bacteraemia caused by members of the hacek group (haemophilus parainfluenzae, aggregatibacter actinomycetemcomitans, aggregatibacter aphrophilus, aggregatibacter paraphrophilus, cardiobacterium spp., eikenella corrodens and kingella spp.) to determine whether endocarditis was present, as defined by the duke criteria. the overall positive predictive value (ppv) of hacek bacteraemia for endocarditis was 60 %. the ppv varied with diffe ... | 2014 | 24681996 |
| influence of titanium ions on cytokine levels of murine splenocytes stimulated with periodontopathic bacterial lipopolysaccharide. | titanium (ti) is frequently used in dental implants because of its excellent corrosion resistance, mechanical properties, and biocompatibility. however, ti ions may be slowly released as a result of corrosion, contributing to peri-implantitis, a major cause of dental implant failure. this study examined the influence of ti ions on cytokine levels in murine splenocytes, an immunocompetent cell type, stimulated with aggregatibacter actinomycetemcomitans lipopolysaccharide (lps) and the influence o ... | 2014 | 24683576 |
| [clinical and microbiological effects of the initial periodontal therapy]. | periodontitis is a destructive inflammatory disease of the tooth-supporting tissues, primarily caused by gram-negative microorganisms. thus, the primary objective of cause-related initial periodontal therapy is disruption and removal of the subgingival biofilm. | 2014 | 24684025 |
| evaluating the antimicrobial activity of commercially available herbal toothpastes on microorganisms associated with diabetes mellitus. | the present study was conducted to evaluate the effcacy of commercially available herbal toothpastes against the different periodontopathogens. | 2013 | 24685799 |
| an in-vitro evaluation of the efficacy of garlic extract as an antimicrobial agent on periodontal pathogens: a microbiological study. | with the rise in bacterial resistance to antibiotics, there is considerable interest in the development of other classes of antimicrobials for the control of infection. garlic (allium sativum linn.) has been used as medicine since ancient times and has long been known to have antibacterial, antifungal, and antiviral properties. this study was undertaken to assess the inhibitory effect of garlic on porphyromonas gingivalis and aggregatibacter actinomycetemcomitans, to assess the time-kill curve o ... | 2013 | 24695825 |
| classification, identification, and clinical significance of haemophilus and aggregatibacter species with host specificity for humans. | the aim of this review is to provide a comprehensive update on the current classification and identification of haemophilus and aggregatibacter species with exclusive or predominant host specificity for humans. haemophilus influenzae and some of the other haemophilus species are commonly encountered in the clinical microbiology laboratory and demonstrate a wide range of pathogenicity, from life-threatening invasive disease to respiratory infections to a nonpathogenic, commensal lifestyle. new sp ... | 2014 | 24696434 |
| blockade of the pi-3k signalling pathway by the aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines. | the aggregatibactor actinomycetemcomitans cytolethal distending toxin (cdt) induces g2 arrest and apoptosis in lymphocytes; these toxic effects are due to the active subunit, cdtb, which functions as a phosphatidylinositol-3,4,5-triphosphate (pip3) phosphatase. we now extend our investigation and demonstrate that cdt is able to perturb human macrophage function. thp-1- and monocyte-derived macrophages were found not to be susceptible to cdt-induced apoptosis. nonetheless, the toxin was capable o ... | 2014 | 24697951 |
| leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol. | antioxidants possess significant therapeutic potential for the treatment of inflammatory disorders. one such disorder is periodontitis characterised by an antimicrobial immune response, inflammation, and irreversible changes to the supporting structures of the teeth. recognition of conserved pathogen-associated molecular patterns is a crucial component of innate immunity to gram-negative bacteria such as escherichia coli, as well as the periodontal pathogen aggregatibacter actinomycetemcomitans. ... | 2014 | 24707119 |