Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| Survival in patients with human papillomavirus positive tonsillar cancer in relation to treatment. | The incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases have increased in the last decades. In parallel, treatment for tonsillar cancer has been intensified e.g., by accelerated radiotherapy, and chemotherapy, resulting in more side effects. Patients with HPV-positive tonsillar cancer have better prognosis than those with HPV-negative tumors, and the former group could hypothetically benefit from reduced, less-toxic treatment without com ... | 2011 | 22038860 |
| A hybrid-capture assay to detect HPV mRNA ratios in cervical specimens. | Human papillomavirus (HPV) DNA screening benefits cervical cancer diagnosis, but a few HPV infections result in cancer. Assays that predict cancer are desirable. A potential biomarker is the ratio of HPV E6-7 over E2 transcripts, which may increase during early cancer progression. Modified hybrid-capture technology detected, in separate wells, HPV E6-7 or E2 mRNA of HPV 16 or HPV 18 in samples. The limit of detection was approximately 1000 copies of in vitro transcribed RNA with linear dynamic r ... | 2012 | 22040847 |
| human papillomavirus genotypes in iranian patients with cervical cancer. | the aim of this study was to determine the frequency of hpv genotypes isolated from cervical intra-epithelial neoplasia grade iii and invasive carcinomas of iranian patients. a total of 94 cases were selected in five years from 2003 to 2007. after nucleic acid purification, real-time pcr was performed by means of gp5+/gp6+ primers. subsequently, pcr products were sequenced, on the basis of which a phylogenetic tree was constructed. negative samples and twelve randomly selected positive samples w ... | 2011 | 22041132 |
| Loss of the a2ß1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro. | Expression of the a2ß1 integrin, a receptor for collagens and laminin, is altered during tumor progression. Recent studies have linked polymorphisms in the a2 integrin gene with oral, squamous cell carcinoma (SCC). To determine the a2ß1 integrin's role in SCC progression, we crossed a2-null mice with K14-HPV16 transgenic animals. Pathological progression to invasive carcinoma was evaluated in HPV-positive, a2-null (HPV/KO) and HPV-positive, wild-type (HPV/WT) animals. a2ß1 integrin expression st ... | 2011 | 22046385 |
| comparison of the immunogenicity of the human papillomavirus (hpv)-16/18 vaccine and the hpv-6/11/16/18 vaccine for oncogenic non-vaccine types hpv-31 and hpv-45 in healthy women aged 18-45 years. | protection against oncogenic non-vaccine types (cross-protection) offered by human papillomavirus (hpv) vaccines may provide a significant medical benefit. available clinical efficacy data suggest the two licensed vaccines (hpv-16/18 vaccine, glaxosmithkline biologicals [gsk], and hpv-6/11/16/18 vaccine, merck & co., inc.) differ in terms of protection against oncogenic non-vaccine hpv types -31/45. the immune responses induced by the two vaccines against these two non-vaccine hpv types (cross-r ... | 2011 | 22048172 |
| Molecular cloning and characterization of a novel human papillomavirus, HPV 126, isolated from a flat wart-like lesion with intracytoplasmic inclusion bodies and a peculiar distribution of Ki-67 and p53. | Infection with certain human papillomavirus types induces warts with specific macroscopic and microscopic features. We observed multiple flat wart-like lesions on the chest, neck and extremities of an adult T-cell leukemia patient. Histologically, atypical intracytoplasmic inclusion bodies currently known to be pathognomonic for genus gamma or mu papillomaviruses were disclosed in some cells of the epidermis showing histological features compatible with flat warts. In the present study, a novel ... | 2012 | 22056388 |
| Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation. | Repression of human papillomavirus (HPV) E6 and E7 oncogenes in established cervical carcinoma cell lines causes senescence due to reactivation of cellular tumor suppressor pathways. Here, we determined whether ongoing expression of HPV16 or HPV18 oncogenes is required for the proliferation of primary human cervical carcinoma cells in serum-free conditions at low passage number after isolation from patients. We used an SV40 viral vector expressing the bovine papillomavirus E2 protein to repress ... | 2012 | 22056390 |
| Multiple human papillomavirus infections and type competition in men. | Background. There is little information on multiple human papillomavirus (HPV) infections and the potential for type competition in men, yet competition may impact the type-specific efficacy of HPV vaccination. Methods. Among 2702 uncircumcised men in Kisumu, Kenya, who were seronegative for human immunodeficiency virus, the observed numbers of HPV types detected were compared with the expected number, which was simulated under the assumption of independent infections. To assess the potential fo ... | 2012 | 22058418 |
| zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge. | topical microbicides that block the sexual transmission of hiv and herpes simplex virus 2 (hsv-2) are desperately needed to reduce the incidence of hiv infections worldwide. previously we completed phase 3 testing of the carrageenan-based gel carraguard. although the trial did not show that carraguard is effective in preventing hiv transmission during vaginal sex, it did show that carraguard is safe when used weekly for up to 2 years. moreover, carraguard has in vitro activity against human papi ... | 2012 | 22064530 |
| Integration of human papillomavirus 18 DNA in esophageal carcinoma 109 cells. | To detect human papillomavirus (HPV) DNA in esophageal carcinoma (EC) 109 cells and investigate the relationship between HPV and EC. | 2011 | 22072858 |
| survey of national immunization programs and vaccine coverage rates in asia pacific countries. | children in the asia pacific region are still suffering from certain vaccine-preventable diseases. the current study surveyed the national immunization programs and vaccine uptake of traditional and newly developed vaccines in 12 countries in this area. the results showed children in most countries were well protected from conventional vaccine-preventable diseases, while immunization programs for certain diseases such as poliovirus or measles should be strengthened in certain countries. protecti ... | 2011 | 22075085 |
| Visual inspection methods for cervical cancer prevention. | The need for simple, cost-effective screening approaches for cervical cancer prevention in low-resource countries has led to the evaluation of visual screening with 3-5% acetic acid. The low reproducibility and wide variation in accuracy reflect the subjective nature of the test. Pooled sensitivity, specificity, positive and negative predictive values were 80%, 92%, 10% and 99%, respectively, for detecting cervical intraepithelial neoplasia grade 2 or worse lesions. Realistic sensitivity of a qu ... | 2011 | 22075441 |
| Comparison of the cobas Human Papillomavirus (HPV) Test with the Hybrid Capture 2 and Linear Array HPV DNA Tests. | The cobas human papillomavirus (HPV) test (cobas) was recently approved by the U.S. Food and Drug Administration (FDA) and identifies HPV16 and HPV18 separately as well as detecting a pool of 11 HR-HPV genotypes (HPV31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -68) and also HPV66. We compared cobas, Linear Array (LA), and Hybrid Capture 2 (HC2) assays for detection of carcinogenic HPV DNA, and cobas and LA for detection of HPV16 and HPV18 DNA, among the first 1,852 women enrolled in the HPV ... | 2012 | 22075592 |
| Safety of quadrivalent human papillomavirus vaccine. | 2011 | 22077556 | |
| Streptococci-Human Papilloma Virus Interaction With Ethanol Exposure Leads to Keratinocyte Damage. | PURPOSE: Ethanol, human papilloma virus (HPV), and poor oral hygiene are risk factors that have been attributed to oral carcinogenesis. Streptococci sp and HPV infections are common in the head and neck, often associated with sexual activity. Although HPV is linked to head and neck squamous cell carcinoma, it is unclear whether there is a similar role for Streptococci sp. This cell study examines whether Streptococci sp and HPV-16 with exposure to ethyl alcohol (ETOH) can act as cofactors in the ... | 2011 | 22079067 |
| sexually transmitted diseases in men who have sex with men. | men who have sex with men (msm) have increased rates of human immunodeficiency virus (hiv) infection and sexually transmitted diseases (stds) compared with demographically matched controls. the reasons for the disproportionate infection burden are complex, including biological, behavioral, and sociocultural factors. hiv and syphilis may often be coprevalent among msm. the use of nucleic acid amplification testing has enhanced the ability to detect frequently asymptomatic gonococcal and chlamydia ... | 2011 | 22080272 |
| distribution of hpv genotypes in cervical intraepithelial lesions and cervical cancer in tanzanian women. | abstract: | 2011 | 22081870 |
| vaccine-preventable diseases and their impact on latin american children. | a joint meeting of the latin american society of pediatric infectious diseases, the dominican society of pediatrics and the dominican society of vaccinology was held in the dominican republic. this report highlights the most relevant issues that were presented and discussed about vaccine-preventable diseases, their epidemiology and impact in latin american children, the need to move forward and expand national immunization programs and the economical and political obstacles to introduce ?new? va ... | 2011 | 22085169 |
| intracervical procedures and the risk of subsequent very preterm birth: a case-control study. | objective. to investigate the relation of prior intracervical procedures with very preterm birth. design. a population-based case-control study. setting. the study was conducted in australia between 2002 and 2004. sample. 345 women having a medically indicated and 236 having a spontaneous singleton birth between 20 and 31 weeks of gestation and 796 women selected randomly from all giving birth at 37 or more weeks of gestation. methods. interview data were analysed using logistic regression. outc ... | 2011 | 22085381 |
| extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma. | background: extracapsular spread (ecs) is commonly used to justify adjuvant chemotherapy in patients with head and neck cancer. the role of ecs as a prognosticator and adjuvant therapy determinant in surgically resected, human papillomavirus-related oropharyngeal squamous cell carcinoma (opscc), however, has never been determined. methods: of 210 oropharynx patients in a prospective transoral laser microsurgery database, 152 patients who had p16-positive primary opscc and pathologically positive ... | 2011 | 22086669 |
| high-risk hpv infection after five years in a population-based cohort of chilean women. | abstract: background: the need to review cervical cancer prevention strategies has been triggered by the availability of new prevention tools linked to human papillomavirus (hpv): vaccines and screening tests. to consider these innovations, information on hpv type distribution and natural history is necessary. this is a five-year follow-up study of gynecological high-risk (hr) hpv infection among a chilean population-based cohort of women. findings: a population-based random sample of 969 women ... | 2011 | 22087645 |
| combined e7-dendritic cell-based immunotherapy and human sodium/iodide symporter radioiodine gene therapy with monitoring of antitumor effects by bioluminescent imaging in a mouse model of uterine cervical cancer. | using a uterine cervical cancer cell line expressing human papillomavirus (hpv) 16 e7 antigen and bioluminescent imaging (bli), we evaluated the therapeutic potential of combined immunotherapy using transfected dendritic cells (dc-e7) and human sodium/iodide symporter (hnis) radioiodine gene therapy in a xenograft animal cancer model. dendritic cells expressing either e7 antigen (dc-e7) or no-insert (dc-no insert) were made for immunization materials, and murine uterine cervical cancer cell line ... | 2011 | 22091632 |
| Human papillomavirus in vaginal intraepithelial neoplasia. | There are limited data on the prevalence and distribution of human papillomavirus (HPV) genotypes in vaginal intraepithelial neoplasia (VAIN). We sought to clarify this issue in a series of 450 VAIN cases with a confirmed diagnosis between 1990 and 2006. HPV genotyping was performed using paraffin-embedded specimens and polymerase chain reaction (PCR)-based methods. Multiple HPV types were validated by E6 type-specific PCR and direct sequencing. The HPV genotypes of the vaginal and cervical neop ... | 2011 | 22095387 |
| Oral sex practices, oral human papillomavirus and correlations between oral and cervical human papillomavirus prevalence among female sex workers in Lima, Peru. | Few data exist on oral human papillomavirus (HPV) prevalence in female sex workers (FSWs). Information regarding oral sex practices of 185 Peruvian FSWs, 18-26 years of age, was obtained via survey and compared with HPV testing results of oral rinse samples. Oral HPV prevalence was 14/185 (7.6%); four (28.9%) HPV genotypes were carcinogenic. One hundred and eighty-two participants reported having had oral sex; 95% reported condom use during oral sex with clients and 9.5% with partners. Women who ... | 2011 | 22096051 |
| the clinical meaning of a cervical intraepithelial neoplasia grade 1 biopsy. | to determine whether the diagnosis of cervical intraepithelial neoplasia (cin) grade 1 increases the risk of cin 3 above what is observed for human papillomavirus (hpv) infection. | 2011 | 22105250 |
| molecular changes in the multistage pathogenesis of head and neck cancer. | head and neck squamous cell carcinomas (scchn) arise in the mucosa of the upper aerodigestive tract at multiple anatomic sites. while tobacco and alcohol exposure remain the primary risk factors for this malignancy, infection with the human papilloma virus is emerging as a major contributing factor to cancers that arise primarily in the oropharynx. despite therapeutic advances, survival has remained relatively unchanged over the past few decades. increased understand of the cellular and molecula ... | 2011 | 22112483 |
| assessment of herd immunity from human papillomavirus vaccination. | 2011 | 22115067 | |
| Analysis of CpG methylation sites and CGI among human papillomavirus DNA genomes. | ABSTRACT: BACKGROUND: The Human Papillomavirus (HPV) genome is divided into early and late coding sequences, including 8 open reading frames (ORFs) and a regulatory region (LCR). Viral gene expression may be regulated through epigenetic mechanisms, including cytosine methylation at CpG dinucleotides. We have analyzed the distribution of CpG sites and CpG islands/clusters (CGI) among 92 different HPV genomes grouped in function of their preferential tropism: cutaneous or mucosal. We calculated t ... | 2011 | 22118413 |
| Compliance with recommended dosing intervals for HPV vaccination among females, 13-17 years, National Immunization Survey-Teen, 2008-2009. | Data from the 2008 and 2009 National Immunization Survey-Teen were analyzed to determine age at initiation of the human papillomavirus vaccine (HPV) series among females 13-17 years (n=7594) and assess compliance with the recommended HPV dosing intervals. Among females who initiated the HPV series, 56.7% of females<13 years at the time of the HPV vaccine recommendation publication did so by age 13; while the majority of females 13-14 and 15-17 years at the time of the recommendation publication ... | 2012 | 22119587 |
| Tuberculosis and Oncogenic HPV: Potential Co-infections in Women at High-risk of Cervical Cancer in Rural China. | The study was embedded in Shanxi Province Cervical Cancer Screening Study II with the aim of examining the association between history of diagnosed tuberculosis or cervical inflammation and oncogenic human papillomavirus (HPV) infection, persistent oncogenic HPV infection, cervical intraepithelial neoplasia grade 3 or cervical cancer (CIN3+) in an isolated rural population of China. A total of 8,798 women were recruited for cervical cancer screening and an interviewer-administered questionnaire. ... | 2011 | 22126473 |
| prevalence of abnormalities influences cytologists' error rates in screening for cervical cancer. | medical screening tasks are often difficult, visual searches with low target prevalence (low rates of disease). under laboratory conditions, when targets are rare, nonexpert searchers show decreases in false-positive results and increases in false-negative results compared with results when targets are common. this prevalence effect is not due to vigilance failures or target unfamiliarity. | 2011 | 22129183 |
| extraction, purification and characterization of the plant-produced hpv16 subunit vaccine candidate e7 ggg. | several studies indicated that biopharmaceuticals based on the recombinant protein e7 of human papillomavirus (hpv) can serve as therapeutic vaccines preventing the development of cancer in women infected with high-risk types of hpv such as hpv16. here, we report effective extraction and purification of a plant-produced e7ggg-lichenase fusion protein, an hpv16 subunit vaccine candidate, from nicotiana benthamiana plants, to a high yield. the target contains the modified hpv16 e7 protein internal ... | 2012 | 22134037 |
| Longitudinal Analysis of Carcinogenic Human Papillomavirus Infection and Associated Cytologic Abnormalities in the Guanacaste Natural History Study: Looking Ahead to Cotesting. | Background. Few studies have addressed the timing of cervical cytologic abnormalities and human papillomavirus (HPV) positivity during the course of an infection. It remains largely unknown how infections detected by HPV and cytology wax and wane relative to each other. The aim of this analysis was to assess the longitudinal relationship of abnormal cytology and HPV positivity in a 7-year prospective study of 2500 women in Guanacaste, Costa Rica.Methods. At each semiannual or annual visit, cervi ... | 2011 | 22147792 |
| Incorporating Calibrated Model Parameters into Sensitivity Analyses: Deterministic and Probabilistic Approaches. | Objective: The aim of this study was to examine how calibration uncertainty affects the overall uncertainty of a mathematical model and to evaluate potential drivers of calibration uncertainty. Methods: A lifetime Markov model of the natural history of human papillomavirus (HPV) infection and cervical disease was developed to assess the cost effectiveness of a hypothetical HPV vaccine. Published data on cervical cancer incidence and mortality and prevalence of pre-cursor lesions were used as end ... | 2011 | 22149631 |
| human papillomavirus l2 facilitates viral escape from late endosomes via sorting nexin 17. | the human papillomavirus (hpv) l2 capsid protein plays an essential role during the early stages of viral infection, but the molecular mechanisms underlying its mode of action remain obscure. using a proteomic approach, we have identified the adaptor protein, sorting nexin 17 (snx17) as a strong interacting partner of hpv l2. this interaction occurs through a highly conserved snx17 consensus binding motif, which is present in the majority of hpv l2 proteins analysed. using mutants of l2 defectiv ... | 2011 | 22151726 |
| prevalence and risk factors of hpv infection among women from various provinces of the world. | objective: we set to estimate the genotype-specific prevalence of human papilloma virus (hpv) and its associated risk factors responsible among women with normal and abnormal cytology by systematic literature survey. methods: reports on hpv prevalence published between 2000 and 2011 were retrieved. to be included, studies required information on cervical cytology, plus detailed descriptions of study populations, ... | 2011 | 22159694 |
| the e6 oncoprotein from hpv16 enhances the canonical wnt/β-catenin pathway in skin epidermis in vivo. | the contribution of the wnt signaling pathway to hpv-induced carcinogenesis is poorly understood. in high-grade dysplastic lesions that are caused by high-risk human papilloma viruses (hr-hpvs), β-catenin is often located in the cell nucleus, which suggests that wnt pathway may be involved in the development of hpv-related carcinomas. most of the oncogenic potential of hr-hpvs resides on the e6 protein's pdz-binding domain. we hypothesized that the pdz-binding domain of the hpv16-e6 oncoprotein ... | 2011 | 22160870 |
| Evaluation of any or type-specific persistence of high-risk human papillomavirus for detecting cervical precancer. | Background:High-risk human papillomavirus (HR-HPV) testing is increasingly important; we examined the impact on accuracy of repeated vs. one-time testing, type-specific vs. pooled detection, and assay analytic sensitivity.Methods:Using a nested case-control design from the ASCUS-LSIL Triage Study, we selected women with incident cervical intraepithelial neoplasia grade 2 or grade 3 (CIN2/3, n = 325) and a random sample of women with <CIN2 as controls (n = 401). HPV DNA status was assessed using ... | 2011 | 22162556 |
| human papillomavirus type-specific prevalence in women with cervical intraepithelial neoplasm in western china. | hpv type-specific prevalence was studied in 600 cases of cervical intraepithelial neoplasm in western china by genoarray test. hpv 16 and 58 were the most prevalent types with the prevalence of 37.8% or 21.8% respectively. hpv 18 or 45 was uncommon type. the result shows different type distributions from that of other regions, which is important evidence for the selection of future genotypes in hpv vaccines in western china. | 2011 | 22170939 |
| Human Papillomavirus Vaccine Intention Among College Men: What's Oral Sex Got to Do With It? | Abstract Objective: To identify associations between engaging in oral sex and perceived risk of oral cancer among college men. Also, to identify associations, and their moderating factors, between oral sex and human papillomavirus (HPV) vaccine acceptance. Methods: Young men were recruited from 2 university campuses in the South (N = 150). Men completed an audio computer-assisted self-administered interview. Results: With the exception of receiving fellatio, each measure of oral sex behavior ... | 2012 | 22171724 |
| clinical performance assessment of five human papillomavirus dna tests using liquid-based cytology samples. | aim: to evaluate the performance of five hpv tests (hybrid capture 2, linear array [la], dna chip, type-specific polymerase chain reaction [pcr], and sequencing) in detecting high-risk (hr) hpv dna and high-grade cervical intraepithelial neoplasia (cin) and cancer. material and methods: a total of 137 women with abnormal cytologies were prospectively enrolled. the diagnostic accuracy of five hpv dna tests in detecting high-grade cin and cancer was assessed, and the concordance among hpv genoty ... | 2011 | 22175246 |
| type-specific human papillomavirus infections among young heterosexual male and female sti clinic attendees. | baseline genotype-specific human papillomavirus (hpv) prevalence rates and associated risk factors per gender enable future assessment of the impact of vaccination on hpv dynamics. | 2012 | 22183851 |
| human papillomavirus infection, vaccination, and cervical cancer communication: the protection dilemma faced by women in southern appalachia. | human papillomavirus is the most frequently occurring sexually transmitted infection and has been recognized as the necessary cause of cervical cancer. understanding the shift in public awareness caused by recent changes to cervical prevention is critical to addressing cervical cancer disparities in appalachia. since the human papillomavirus vaccine was approved for prevention, little data have been collected regarding human papillomavirus risk assessment and vaccine perceptions among appalachia ... | 2011 | 22185292 |
| Acceptability of self-collected human papillomavirus specimens as a primary screen for cervical cancer. | The aim of this study was to compare the acceptability of self-collected vs clinician-collected human papillomavirus (HPV) tests. Utilising a cross-sectional approach, 250 non-pregnant, 25-60-year-old women from Leon, Nicaragua self-collected vaginal swabs and brushes for HPV and received a pelvic examination for liquid-based cytology and reflex HPV. Subjects underwent colposcopy, with biopsy if indicated, and completed questionnaires comparing their perceptions of HPV testing methods. Acceptabi ... | 2012 | 22185546 |
| expanding the clinical and genetic spectrum of human cd40l deficiency: the occurrence of paracoccidioidomycosis and other unusual infections in brazilian patients. | cd40 ligand (cd40l) deficiency or x-linked hyper-igm syndrome (x-higm) is a well-described primary immunodeficiency in which pneumocystis jiroveci pneumonia is a common clinical feature. we have identified an unusual high incidence of fungal infections and other not yet described infections in a cohort of 11 x-higm patients from nine unrelated brazilian families. among these, we describe the first case of paracoccidioidomycosis (pcm) in x-higm. the molecular genetic analysis of cd40l was perform ... | 2011 | 22193914 |
| comparison of the cobas 4800 human papillomavirus test against a combination of the amplicor human papillomavirus and the linear array tests for detection of hpv types 16 and 18 in cervical samples. | the greater prevalence of human papillomavirus (hpv) types 16 and 18 compared to the other high-risk hpv types of cervical cancer led to the development of clinical tests that detect both types separately from other genotypes. one method is the roche cobas 4800 hpv test, which is based on a real-time pcr. the aim of this study was to evaluate the performance of the cobas 4800 hpv test for detecting genotypes 16 and 18 by comparing the results with those obtained in a combination of the roche amp ... | 2011 | 22197189 |
| adolescent perceptions of risk and need for safer sexual behaviors after first human papillomavirus vaccination. | to (1) examine perceptions of risk of human papillomavirus (hpv) and other sexually transmitted infections (stis), (2) examine perceived need for safer sexual behaviors, and (3) determine factors associated with less perceived need for safer sexual behaviors, all in the context of receiving the first hpv vaccination. | 2012 | 22213755 |
| automated detection of dual p16/ki67 nuclear immunoreactivity in liquid-based pap tests for improved cervical cancer risk stratification. | the papanicolau (pap) test is a routine cytological procedure for early detection of dysplastic lesions in cervical epithelium. a reliable screening method is crucial for triage of women at risk; however manual screening and interpretation are associated with relatively low sensitivity and substantial interobserver diagnostic variability. p16 and ki67 biomarkers have been recently proposed as adjunctive tools in the diagnosis of high-risk human papillomavirus (hrhpv) associated dysplasias to sup ... | 2012 | 22215277 |
| prevalence of human papilloma virus in esophageal carcinomas: a polymerase chain reaction-based study. | objectives: human papilloma virus (hpv) has been repeatedly found in esophageal carcinoma tissues. however, detection rates of hpv dna in these tumors have varied markedly. differences in detection methods, sample types and geographic regions of the sample origin have been suggested as potential causes of this discrepancy. this study was undertaken to analyze the prevalence of hpv in esophageal carcinoma. study design: hpv l1 dna was evaluated in a total of 49 esophageal carcinoma samples, inclu ... | 2012 | 22236750 |
| a new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: immunohistochemical and molecular study and review of the literature. | abstract: background: as a rule, endocervical tumours with signet-ring cell are classed as metastatic extra-genital neoplasms. in a patient aged 45 years, we describe primary cervical signet-ring cell carcinoma (pcsrcc) characterized by prominent endometrial and myometrial involvement, simulating primary endometrial adenocarcinoma with cervical extension. in addition, a review of the literature was made to identify the clinical and pathological features of this rare malignancy. case presentatio ... | 2012 | 22236794 |
| incidence of human papillomavirus infection in male sexual partners of women diagnosed with cin ii-iii. | human papillomavirus (hpv) infection is a very common sexually transmitted disease which has been strongly related to cervical cancer and cervical intraepithelial neoplasia (cin), penile cancer and intraepithelial and infiltrating anal squamous cell carcinoma. to describe the hpv status of male sexual partners of women diagnosed with cin ii/iii and to evaluate the practical usefulness of the hpv detection in urine as a reliable marker of genital high-risk hpv infection in men. ninety-one heteros ... | 2012 | 22240393 |
| human papillomavirus 18 e6 inhibits phosphorylation of p53 expressed in hela cells. | abstract: background: in hpv infected cells p53 function is abrogated by e6 and even ectopically expressed p53 is unable to perform tumor suppressor functions. in addition to facilitating its degradation, e6 may also inhibit p53 transactivity, though the mechanisms are still poorly understood. it has been reported that inhibition of p300, an acetyltransferase responsible for p53 acetylation is inactivated by e6. activation of overexpressed p53 to cause cell growth inhibition is facilitated by i ... | 2012 | 22244155 |
| [expression of runx3 in cervical carcinoma and its clinical significance]. | objective to explore the role of runt-related transcription factor 3(runx3) in the tumorgenesis and progression of cervical carcinoma. methods the immunohistochemical staining technique was used to detect the expression of runx3 protein in 25 cases of normal cervix, 34 intraepithelia neoplasia (cin), and 48 cervical carcinomas. sybr greenichimeric fluorescence real-time pcr was applied to detect the expression of runx3 mrna in 10 cases of normal cervix, 24 cin, and 30 cervical carcinomas. result ... | 2011 | 22246363 |
| topical vitamin a treatment of recalcitrant common warts. | abstract: background: common warts (verruca vulgaris) are benign epithelial proliferations associated with human papillomavirus (hpv) infection. salicylic acid and cryotherapy are the most frequent treatments for common warts, but can be painful and cause scarring, and have high failure and recrudescence rates. topical vitamin a has been shown to be a successful treatment of common warts in prior informal studies. case the subject is a healthy, physically-active 30 old female with a 9 year hist ... | 2012 | 22251397 |
| the interplay of age stratification and hpv testing on the predictive value of asc-us cytology: results from the athena hpv study. | we have previously shown that human papillomavirus (hpv) genotyping, using the cobas hpv test (roche molecular systems, pleasanton, ca), can be used to identify women with atypical squamous cells of undetermined significance (asc-us) at the highest risk for cervical intraepithelial neoplasia (cin) grade 2 or worse. we investigated the impact of age stratification on the risk of cin 2 or worse in women with asc-us and the performance of hpv genotyping in different age strata. the sensitivity of t ... | 2012 | 22261457 |
| high-risk cutaneous squamous cell carcinoma. | cutaneous squamous cell carcinoma (cscc) is the second most common form of skin cancer and its incidence has increased in recent decades. most csccs are successfully treated by surgery, but local and distant metastases develop in approximately 5% of cases; this proportion is higher in certain forms of cscc with high-risk factors, namely: tumor size >2cm, depth >2mm, clark level ≥iv, perineural invasion, lymphovascular invasion, poor differentiation, certain histologic subtypes (desmoplastic or a ... | 2012 | 22261673 |
| high-risk human papillomavirus infection in bowen's disease of the nail unit: report of three cases and review of the literature. | background: bowen's disease (bd) of the nail unit is associated with human papillomavirus (hpv) infection. objective: this study aimed to investigate the frequency of high-risk hpv infection, gender, age and digital distribution in this condition. methods: biopsy specimens of 3 consecutive cases with periungual bd were investigated for the presence of hpv dna by in situ hybridization and by polymerase chain reaction (pcr). furthermore, 74 cases of ungual bd conducted with hpv genotyping as repor ... | 2012 | 22269697 |
| human papillomavirus (hpv) detection and papanicolaou cytology in low-resource women in posadas city, misiones, argentina. | the objective of this study was to determine the prevalence of hpv infection and cervical lesions present in women who attended a health center in a low-resource area of the city of posadas, misiones, argentina. cervical cell samples (n = 163) were processed for papanicolaou cytology and hpv-pcr tests. socio-cultural risk factors were estimated using the odds ratio (or, ci 95 %). cervical lesions were detected in 14.7 % of women. the general prevalence of hpv infection was of 38 %. the most comm ... | 2011 | 22274823 |
| human papillomavirus-positive oral cavity and oropharyngeal cancer patients do not have better quality-of-life trajectories. | objective. to determine the role of human papillomavirus (hpv) status on quality of life (qol) in patients with oral cavity and oropharyngeal squamous cell carcinoma (oscc). since oscc that are associated with high-risk hpv have an improved response to treatment and survival, we hypothesized that patients with these tumors would have better qol trajectories.study design. prospective cohort study.setting. tertiary care academic medical center and 2 affiliated hospitals.subjects and methods. head ... | 2012 | 22275190 |