Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| knowledge of hpv in west virginia high school health students and the effects of an educational tool. | study objective: to assess the knowledge of human papillomavirus (hpv) in west virginia high school students, create an educational dvd that could be used as a supplement to health class, and evaluate whether our intervention increases student knowledge of hpv. design: prospective, randomized experimental design with analysis of questionnaire data. setting: west virginia high school health class. participants: a total of 626 students participated. interventions: hpv educational dvd designed by h ... | 2011 | 21600809 |
| follow-up outcomes for a large cohort of us women with negative imaged liquid-based cytology findings and positive high risk human papillomavirus test results. | objective: this study aimed to follow a large group of us women with negative computer-imaged liquid-based cytology (lbc) and positive high risk (hr) hpv dna results. methods: negative lbc and positive hrhpv cases were identified between july 1, 2005 and december 31, 2009. cytologic and histopathologic follow-up results, repeat hpv results, and prior history were analyzed. results: 1099 patients with negative lbc and positive hrhpv results were identified. eight hundred sixty-nine had repeat pap ... | 2011 | 21601911 |
| magnetic microparticle-based multiplexed dna detection with biobarcoded quantum dot probes. | we have developed a new analytical method to detect multiple dna simultaneously based on the biobarcoded cdse/zns quantum dot (qd) and magnetic microparticle (mmp). it was demonstrated by using oligonucleotide sequences of 64 bases associated with human papillomavirus 16 and 18 l1 genes (hpv-16 and hpv-18) as model systems. this analytical system involves three types of probes, a mmp probe and two streptavidin-modified qd probes. the mmps are functionalized with hpv-16 and hpv-18 captures dna to ... | 2011 | 21602038 |
| a long-term prospective study of type-specific human papillomavirus infection and risk of cervical neoplasia among 20,000 women in the portland kaiser cohort study. | background. human papillomavirus (hpv) dna testing is more sensitive than cytology for detection of cervical intraepithelial neoplasia grade 3 and cancer (>cin3). adding hpv testing to cytology is recommended for women >30 but long-term prospective studies of hpv testing are rare. methods. beginning in 1989-1990, ~20,000 women in a pre-paid health maintenance organization (median age = 34) were followed passively by recommended annual cytology. we tested archived cervicovaginal lavage specimens ... | 2011 | 21602310 |
| human papillomavirus testing in primary cervical screening and the cut-off level for hybrid capture 2 tests: systematic review. | to determine the trade-off between the sensitivity and the specificity for high grade cervical intraepithelial neoplasia at hybrid capture 2 cut-off values above the standard ≥1 relative light units/cut-off level (rlu/co). | 2011 | 21606136 |
| interrelationship between the expression of h-ras p21, c-myc and p53 proteins, and the infection of high-risk human papillomaviruses in japanese patients with esophageal squamous-cell carcinoma. | the presence and distribution of increased expression of h-ras p21 protein, c-myc protein and p53 protein, or of human papillomavirus (hpv) dna were investigated in 42 japanese patients with esophageal squamous cell carcinoma (scc) by immunohistochemical techniques using each protein antibody, and by in situ hybridization with fluorescein isothiocyanate (fitc)-labelled dna. probes for hpv-16 and hpv-18. eighteen cases were positive with h-ras p21 antibody, but only one with c-myc protein antibod ... | 1994 | 21607450 |
| prevalence of human papillomavirus, epstein-barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in hong kong patients. | background: the purpose of this study of human papillomavirus (hpv), epstein-barr virus (ebv), p21, and p53 in sinonasal inverted papilloma (ip) was to help elucidate its pathogenesis. methods: seventy-three ips, 48 nasal polyps, and 85 hypertrophied turbinates were subjected to hpv polymerase chain reaction (pcr) study. seventy-three ips, 30 nasal polyps, and 32 hypertrophied turbinates were subjected to ebv in situ hybridization (ish), p21, and p53 immunohistochemical (ihc) studies. results: h ... | 2011 | 21608063 |
| [detection of human papilloma virus (hpv) in liquid-based cervical samples. correlation with protein p16ink4a expression]. | the liquid-based cervical cytology improves the quality of the sample and the residual sample could be used efficiently to carry out complementary tests, such as the detection of hpv dna and the immunocytochemical biomarkers study. the purpose of this study was to correlate the presence of hpv and immunoexpression of p16ink4a in liquid-based cervical samples to examine the utility of these new tools in the detection of cervical cancer. the included patients (n = 67) presented an abnormal cytolog ... | 2011 | 21614811 |
| a systemic review of human papillomavirus studies: global publication comparison and research trend analyses from 1993 to 2008. | the term "human papillomavirus" has been used as the keyword during searching titles, abstracts, and keywords based on the online version of science citation index (sci), web of science from 1993 to 2008. twelve document types were found among the 14,943 papers published in 1,072 journals that were listed in 99 sci subject categories. all the articles referring to human papillomavirus were assessed by using the following aspects: characteristics of publication output, distribution of output in j ... | 2011 | 21614898 |
| human papillomavirus (hpv) vaccination: perception and practice among french general practitioners in the year since licensing. | acceptance of the human papillomavirus (hpv) vaccine by targeted populations will depend to a large extent on its acceptability among physicians. we examined the perceptions, attitudes and practices of general practitioners (gps) in relation to hpv vaccination. from november 2007 to april 2008, a cross-sectional survey was carried out among a representative 5% sample of gps in the large rhône-alpes region of france. both quantitative (self-administered questionnaire) and qualitative (interview) ... | 2011 | 21616114 |
| human papillomavirus genotypes among infected thai women with different cytological findings by analysis of e1 genes. | cervical cytological data may not be sufficient for cervical cancer screening and prevention. in this project, we determined hpv genotype among infected thai women with different cytological findings by characterization of e1 genes. five hundred and thirty-five specimens were tested by pcr amplification of the e1 genes. hpv genotypes were determined by sequencing, comparison with the genbank database and were analyzed in relation to different cytological findings. hpv-dna by pcr were typed and r ... | 2011 | 21617826 |
| distribution of human papillomavirus genotypes in paraguayan women according to the severity of the cervical lesion. | the incidence of cervical cancer in paraguay is among the highest in the world. this study aimed to determine the distribution of human papillomavirus (hpv) genotypes in paraguayan women, according to the severity of the cervical lesion. this cross-sectional study included 207 women without a squamous intraepithelial lesion, 164 with low-grade squamous intraepithelial lesions, 74 with high-grade squamous intraepithelial lesions, and 41 with cervical cancer. type-specific hpv was determined by th ... | 2011 | 21618554 |
| improved genetic association tests for an ordinal outcome representing the disease progression process. | we are interested in detecting genetic variants that influence transition between discrete stages of a disease progression process, such as the natural history of progression to cervical cancer with the following four stages: (1) normal-human papillomavirus (hpv) exposed, (2) persistent infection with oncogenic hpv, (3) cervical intraepithelial neoplasia grades 2 or 3 (cin2/3), and (4) cervical cancer. standard statistical tests derived from the proportional odds model or polytomous regression m ... | 2011 | 21618605 |
| hpv vaccine information-seeking behaviors among us physicians: government, media, or colleagues? | the multiple information sources available may pose a challenge to physicians in providing accurate human papillomavirus (hpv) vaccine information to patients. the purpose of this study was to describe physicians' hpv vaccine information-seeking behaviors and assess if these behaviors differ by physician specialty and sociodemographic characteristics. in 2009, 1008 family physicians (fps), pediatricians (peds), and obstetricians/gynecologists (obgyns) completed a survey to assess their hpv vacci ... | 2011 | 21619906 |
| clinicopathologic correlations between human papillomavirus 16 infection and beclin 1 expression in human cervical cancer. | our earlier study showed that the autophagy gene beclin 1 could affect cell proliferation in a cervical cancer hela cell line. in this study, we examined beclin 1 protein expression in 81 specimens of cervical squamous carcinoma by immunohistochemistry. meanwhile, we detected e6 and e7 genes of human papillomavirus 16 in these tissues by polymerase chain reaction. beclin 1 expression significantly decreased in samples of malignant cervical cancer tissues than in those of normal or cervical intra ... | 2011 | 21623196 |
| incidence of cervical intraepithelial neoplasia grade 2 or worse in colposcopy-negative/human papillomavirus-positive women with low-grade cytological abnormalities. | please cite this paper as: kelly r, walker p, kitchener h, moss s. incidence of cervical intraepithelial neoplasia grade 2 or worse in colposcopy-negative/human papillomavirus-positive women with low-grade cytological abnormalities. bjog 2011; doi: 10.1111/j.1471-0528.2011.02970.x objective to determine the risk of incident high-grade cervical intraepithelial neoplasia (cin) in human papillomavirus (hpv) -positive women with low-grade cytological abnormalities who had a satisfactory normal colp ... | 2011 | 21624034 |
| prevalence and distribution of high risk human papillomavirus (hpv) types 16 and 18 in carcinoma of cervix, saliva of patients with oral squamous cell carcinoma and in the general population in karnataka, india. | background: in view of conducting hpv vaccination in india it is most important to understand the prevalence of hpv genotypes in this population, not only in squamous cell carcinoma of cervix and oral cavity but also in the general population. in this study we explored the prevalence and distribution of high-risk hpv types 16 and 18 in carcinoma of cervix, saliva of patients with oral squamous cell carcinoma and in general population in karnataka. methods: cervical cancer specimens after punch b ... | 2011 | 21627358 |
| detection of high-risk human papillomavirus types 16 and 18 but not 33 and 52 in external genital warts from iranian females. | background: external genital warts (egw) are relatively common sexually transmitted diseases. in the majority of cases, low-risk human papilomaviruses (hpv), such as hpv-6 and hpv-11, are responsible but, high-risk types may also be detected and this has a bearing on vaccines for cervical cancer prevention. in this study the incidence of the high-risk hpv types 16, 18, 33 and 52 in egws of females from the southwest of iran was assessed. methods: seventy-nine women with egws participated in this ... | 2011 | 21627381 |
| a competitive serological assay shows naturally acquired immunity to human papillomavirus infections in the guanacaste natural history study. | background. a competitive luminex immunoassay (clia) has been developed to measure neutralizing antibodies against human papillomavirus (hpv) types 6, 11, 16 and 18. methods. in a cohort of 974 women from the guanacaste natural history study, we studied the relationship of baseline clia and virus-like particle (vlp) enzyme-linked immunosorbent assay (elisa) (hpv16 and hpv18 only) seropositivity to measures of hpv exposure, hpv dna positivity, number of sexual partners, cytology findings, and age ... | 2011 | 21628663 |
| improved sensitivity of vaginal self-collection and high-risk human papillomavirus testing. | background: self-collected vaginal specimens tested for high-risk human papillomavirus (hr-hpv) have been shown to be less sensitive for detection of cervical intraepithelial neoplasia or cancer (≥cin 3) than physician-collected endocervical specimens. to increase the sensitivity of self-collected specimens, we studied a self-sampling device designed to obtain a larger specimen from the upper vagina (poi/nih self-sampler) and a more sensitive pcr based hr-hpv assay. materials and methods: 10,000 ... | 2011 | 21630255 |
| hpv vaccine against hpv infection and disease in males. | 2011 | 21631334 | |
| an evaluation of a new dna test for carcinogenic human papillomavirus. | using archived specimens, we evaluated a new automated real-time pcr assay (bd diagnostics), which detects all carcinogenic hpv and provides hpv genotyping for seven of them, including hpv16 and hpv18, the two most carcinogenic hpv genotypes. we found comparable results with hybrid capture 2 (hc2) for detection of carcinogenic hpv (n = 473) and with linear array and line blot assay (n = 371) for detection of individual hpv genotypes. | 2011 | 21632892 |
| oncogenic potential of human papillomavirus (hpv) and its relation with cervical cancer. | abstract: human papillomavirus (hpv) is the most common cause of cervical cancer. cervical cancer being the second most common cancer after lung cancer, affecting women of different age groups; has a prevalence of about 20% in young sexually active women. among different types of hpv, hpv16 the major strain causing this cancer and is sexually transmitted had been unnoticed for decades. keeping in mind the multiple risk factors related with cervical cancer such as early age sexual activities, tee ... | 2011 | 21635792 |
| reduced mir-100 expression in cervical cancer and precursors and its carcinogenic effect through targeting plk1 protein. | aim: although aberrant mirnas expression has been documented, altered mir-100 expression in cervical cancer and precursor tissues and its carcinogenic effect and mechanism remain unexplored. the aim of our study was to investigate the role of mir-100 alteration in cervical carcinogenesis. methods: the expression of mir-100 was examined by quantitative real-time reverse transcriptase pcr (qrt-pcr) in 125 cervical tissues including normal cervical epithelium, cervical intraepithelial neoplasia (ci ... | 2011 | 21636267 |
| the epidemic of hpv-associated oropharyngeal cancer is here: is it time to change our treatment paradigms? | although relatively uncommon, oropharyngeal cancers are increasing in incidence despite declining prevalence of smoking and in direct opposition to a decreasing incidence of all other head and neck cancers. an epidemic of human papillomavirus (hpv)-associated oropharyngeal cancers seems to account for these incidence trends. important demographic, behavioral, and prognostic characteristics define this unique population. changes in prevention, diagnosis, evaluation, staging, and treatment are nee ... | 2011 | 21636538 |
| hpv protection in older groups may be in the eye of the beholder. | 2011 | 21647126 | |
| quadrivalent papillomavirus vaccine in women over age 26. cervical screening must remain a priority. | 2011 | 21648175 | |
| antitumor therapeutic and antimetastatic activity of electroporation-delivered human papillomavirus 16 e7 dna vaccines: a possible mechanism for enhanced tumor control. | dna vaccines are known to be lacking in immunogenicity in humans. presently, electroporation (ep) is thought to overcome this limitation. here, we investigate whether human papillomavirus 16 e7 dna vaccines delivered by ep might elicit potent antitumor activity in animal cervical cancer models, with a focus on the underlying mechanism(s). intramuscular (im)-ep delivery of e7 dna vaccines induced more potent antitumor therapeutic and antimetastatic activity compared with im delivery. moreover, th ... | 2011 | 21649506 |
| providing vaccines against human papillomavirus to adolescent girls in the americas: battling cervical cancer, improving overall health. | vaccines against the human papillomavirus (hpv)--the primary cause of cervical cancer--target adolescent girls, many of whom have limited contact with health services. countries in the americas are beginning to use hpv vaccines to increase the impact of cervical cancer programs and as an entry point to broader health services for girls. this strategy opens new opportunities to improve lifelong health habits; encourage regular cervical cancer screening and treatment, when necessary; and offer ass ... | 2011 | 21653962 |
| serum antibodies to the hpv16 proteome as biomarkers for head and neck cancer. | human papillomavirus (hpv) type 16 is associated with oropharyngeal carcinomas (opc). antibodies (abs) to hpv16 e6 and e7 oncoproteins have been detected in patient sera; however, abs to other early hpv-derived proteins have not been well explored. | 2011 | 21654689 |
| pcr study of a series of ascus cases hpv-positive by hcii. | most guidelines currently recommend the testing of human papillomavirus (hpv) in ascus cases. the most used method for this purpose is hybrid capture ii (hcii), but pcr techniques with gp5+/6+ primers can be also applied. furthermore, the hcii high-risk probe test for detection of hpv shows cross-reactivity with low-risk hpv. although this cross-reactivity has been studied in screening populations, it has received little attention in ascus cases. to compare the performance of the hcii high-risk ... | 2011 | 21656701 |
| prognostic implication of high risk human papillomavirus e6 and e7 mrna in patients with intraepithelial lesions of the cervix in relationship to age. | since the introduction of the cytological screening programs, a significant reduction in the incidence of cervical cancer has been achieved. almost all of these cancers are related to high-risk (hr) human papillomavirus (hpv) cervical infections. however, the natural history of hpv infection seems to be different in younger patients, resulting in a higher rate of regression. there is, therefore, the need to identify hpv-related biomarkers in order to enhance the effectiveness of screening of hig ... | 2011 | 21658320 |
| adult immunizations: update on recommendations. | the advisory committee for immunization practices recommends universal influenza vaccination for 2010-2011. older adults should be offered protection against herpes zoster, and younger adults should receive immunization against human papilloma virus and pertussis. hepatitis b vaccination should be encouraged in non-immune adults. recommendations also address vaccinations for tetanus/diphtheria, hepatitis a, pneumococcus, measles/mumps/rubella, and meningococcus. | 2011 | 21658665 |
| [investigation on hpv dna detection and genotyping practices used in french laboratories in 2009]. | the french national reference laboratory for human papillomavirus (hpv) performed in 2009 a national study in order to review the methods used to detect and identify hr hpv genotypes in microbiology laboratories. results from this study show a great diversity in volumes of samples treated in laboratories. among clinical indications, the most frequent is a result of asc-us at a pap smear. this indication in the only one covered by the national public insurance system and is mostly performed in la ... | 2011 | 21659046 |
| meeting of the who human papillomavirus vaccine advisory committee, april 2010. | 2011 | 21661272 | |
| new technologies and advances in colposcopic assessment. | to have a good grasp of clinical colposcopy, it is necessary to understand the histopathologic structure of the normal and dysplastic cervical epithelium. previous meta-analyses had indicated high overall sensitivity of colposcopy in detecting dysplastic lesions, but recent studies have suggested that the technique has much lower sensitivity in detecting high-grade intraepithelial neoplasia. the best practice in colposcopy relies on accurately taking a biopsy from the correct (i.e. most morpholo ... | 2011 | 21664876 |
| human papillomavirus dna and mrna positivity of the anal canal in women with lower genital tract hpv lesions: predictors and clinical implications. | women with hpv related pathology of the lower genital tract are at higher risk for ain and anal cancer than the general population. a strategy to identify anal disease in these women has not been formulated. the aim of this study is to examine the feasibility of hpv related biomarker testing on anal smears, to identify the risk factors for anal hpv positivity and to provide information of the clinical implications of anal hpv infection in this population. | 2011 | 21665253 |
| the role of human papillomavirus on sperm function. | to review the role of human papillomavirus (hpv) on sperm parameters, fertility and implication of the use of infected sperm cells in assisted reproduction. | 2011 | 21666465 |
| transforming activity of a novel mutant of hpv16 e6e7 fusion gene. | an optimized recombinant hpv16 e6e7 fusion gene (hpv16 ofe6e7) was constructed according to codon usage for mammalian cell expression, and a mutant of hpv16 ofe6e7 fusion gene (hpv16 omfe6e7) was generated by site-directed mutagenesis at l57g, c113r for the e6 protein and c24g, e26g for the e7 protein for hpv16 ofe6e7 [patent pending (cn 101100672)]. the hpv16 omfe6e7 gene constructed in this work not only lost the transformation capability to nih 3t3 cells and tumorigenicity in scid mice, but a ... | 2011 | 21667341 |
| higher micronutrient intake is associated with human papillomavirus-positive head and neck cancer: a case-only analysis. | no studies have investigated dietary differences between head and neck squamous cell carcinoma (hnscc) patients with human papillomavirus (hpv)-positive tumors and patients with hpv-negative tumors. this study was designed to investigate the relationship between diet and hpv status in hnscc patients. cases of hnscc were recruited from 2 clinical centers participating in the university of michigan head and neck specialized program of research excellence (spore). hpv tissue genotyping was performe ... | 2011 | 21667401 |
| racial disparities in awareness of the human papillomavirus. | abstract background: human papillomavirus (hpv) is the most common sexually transmitted infection in the united states yet is one of the least recognized among the general public. hpv awareness may be relatively low among minority women. because hpv awareness is associated with uptake of the hpv vaccine, it is critical to assess hpv awareness in the population and identify any racial/ethnic gaps. methods: this study used nationally representative data collected by the national survey of family g ... | 2011 | 21668381 |
| human papillomavirus genotype distribution among french women with and without cervical abnormalities. | to assess human papillomavirus (hpv) prevalence and distribution among french women with normal and pathologic cytology findings. | 2011 | 21669421 |
| serum antibody response following genital {alpha}9 human papillomavirus infection in young men. | background.ôçâalthough the prevalence of human papillomavirus (hpv) genital infection is similarly high in males and females, seroprevalence is lower in males. this study assessed rates and determinants of seroconversion after detection of genital hpv infection in young men. methods.ôçâwe investigated hpv type-specific seroconversion in a cohort of heterosexual male university students who had an ╬▒9 hpv type (hpv-16, -31, -33, -35, -52, -58, or -67) detected in the genital tract (n = 156). hpv ... | 2011 | 21673030 |
| postlicensure safety evaluation of human papilloma virus vaccines. | a summary of postlicensure safety information of hpv vaccines from three sources: vigibase, the global database of who's programme for international drug monitoring, the vaers report on gardasil and the rivm report on cervarix. | 2011 | 21673418 |
| evolution and taxonomic classification of human papillomavirus 16 (hpv16)-related variant genomes: hpv31, hpv33, hpv35, hpv52, hpv58 and hpv67. | human papillomavirus 16 (hpv16) species group (alpha-9) of the alphapapillomavirus genus contains hpv16, hpv31, hpv33, hpv35, hpv52, hpv58 and hpv67. these hpvs account for 75% of invasive cervical cancers worldwide. viral variants of these hpvs differ in evolutionary history and pathogenicity. moreover, a comprehensive nomenclature system for hpv variants is lacking, limiting comparisons between studies. | 2011 | 21673791 |
| low-level persistence of human papillomavirus 16 dna in a cohort of closely followed adolescent women. | most human papillomavirus (hpv) infections in young women become undetectable by standard assays after a few months. it is possible that many hpv infections do not actually clear, but persist at very low levels for years, becoming detected again later in life. the purpose of this study is to describe hpv 16 clearance, reappearance, and low-level persistence in a cohort of adolescent women. adolescent women (nôçë=ôçë66), not vaccinated against hpv, were recruited from 1998 to 2008 into a longitud ... | 2011 | 21678439 |
| value of hpv-dna test in women with cytological diagnosis of atypical glandular cells (agc). | objective: this study analyzed whether hpv (human papillomavirus) testing contributes towards defining histological abnormalities in women with atypical glandular cells (agc) diagnosed at cervical cytology. study design: one hundred and eight women with conventional cervical cancer screening smears suggestive of agc not otherwise specified (agc-nos) and favor neoplastic (agc-fn) were consecutively enrolled. all women underwent colposcopic examinations and biopsy was performed according to the cy ... | 2011 | 21680079 |
| implementation of e-bug in denmark. | bacterial resistance to antimicrobial agents in primary healthcare is low in denmark compared with most other european countries. denmark has a vaccination programme for children that recommends immunization against 10 infectious diseases, including a heptavalent pneumococcal conjugate vaccine (pcv7) and a vaccine against human papillomavirus (hpv). outbreaks in schools due to other infectious illnesses are well recognized and have seasonal variations. a quarter of young people have had a sexual ... | 2011 | 21680590 |
| early effect of the hpv vaccination programme on cervical abnormalities in victoria, australia: an ecological study. | australia introduced a human papillomavirus (hpv) vaccination programme with the quadrivalent hpv vaccine for all women aged 12-26 years between 2007 and 2009. we analysed trends in cervical abnormalities in women in victoria, australia, before and after introduction of the vaccination programme. | 2011 | 21684381 |
| human papillomavirus vaccination in the resourced and resource-constrained world. | human papillomavirus has been established as the causal agent for cervical cancer. the identification of a clear cause presents an unparalleled opportunity for cancer control. as such, the development of prophylactic human papillomavirus vaccines has been rightly hailed as one of the significant scientific triumphs of the past 20 years. this story of scientific triumph over disease, however, is not yet complete. the fruit of scientific labour must be delivered to the people in order to fulfil th ... | 2011 | 21684811 |
| Human papillomavirus (HPV) detection using in situ hybridization in histologic samples: correlations with cytologic changes and polymerase chain reaction HPV detection. | Although in situ hybridization (ISH) and polymerase chain reaction (PCR) have extensively been used on cytology specimens, there have been limited reports of the usefulness of these techniques in relation to confirmed histologic findings. In this study, we used PCR and ISH to detect human papillomavirus (HPV) in cytologic and histologic specimens, respectively. By using positive and negative likelihood ratios, we attempted to identify any predictive role of ISH testing alone or in combination wi ... | 2011 | 21685039 |
| the strong protective effect of circumcision against cancer of the penis. | male circumcision protects against cancer of the penis, the invasive form of which is a devastating disease confined almost exclusively to uncircumcised men. major etiological factors are phimosis, balanitis, and high-risk types of human papillomavirus (hpv), which are more prevalent in the glans penis and coronal sulcus covered by the foreskin, as well as on the penile shaft, of uncircumcised men. circumcised men clear hpv infections more quickly. phimosis (a constricted foreskin opening impedi ... | 2011 | 21687572 |
| why do young women get tested for sexually transmitted infections? evidence from the national longitudinal study of adolescent health. | abstract purpose: public health officials promote sexually transmitted infection (sti) testing as a method to reduce the morbidity of stis. the purpose of this study was to examine what factors are associated with sti testing among young women across various types of stis and to compare relative influences of factors across models. methods: a secondary data analysis of data from add health wave iii was conducted (n=2629). explanatory factors highlighted in qualitative literature were operational ... | 2011 | 21689024 |
| associations of human leukocyte antigen class ii genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk. | background: only a small proportion of women infected with human papillomavirus type 18 (hpv18) may progress to persistent infection and cervical neoplasia. this community-based cohort study aimed to assess associations with human leukocyte antigen (hla) class ii genotypes for natural infection of hpv18 and subsequent risk of cervical neoplasia. methods: among 10,190 cytologically normal participants, 125 with hpv18 infection were identified by hpv blot kit. hpv18 viral load at study entry was e ... | 2011 | 21692064 |
| human papillomavirus 13 in a mexican mayan community with multifocal epithelial hyperplasia: could saliva be involved in household transmission? | multifocal epithelial hyperplasia (meh) is a disease of the oral mucosa. human papillomaviruses 13 and 32 have been detected in these lesions. we describe the epidemiology and clinical characteristics of patients with meh in a rural community in the mayan area of mexico with 53 cases and 54 controls. clinical and epidemiological data were collected through a direct interview. oral cell samples were collected with a cytobrush. subjects collected their own saliva sample in a sterile bottle. all sa ... | 2011 | 21697033 |
| the e7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle. | human papillomaviruses (hpvs) are the causative agents of several important genital and other mucosal cancers. the hpv16 e7 gene encodes a viral oncogene that is necessary for the continued growth of cancer cells, but its role in the normal, differentiation-dependent life cycle of the virus is not fully understood. the function of e7 in the viral life cycle was examined using a series of mutations of e7 created in the context of the complete hpv16 genome. the effect of these e7 mutations on key ... | 2011 | 21697473 |
| detection and genotyping of human papilloma virus in cervical cancer specimens from saudi patients. | to determine the rates and types of human papilloma virus (hpv) infection in cervical cancer specimens from saudi patients. | 2011 | 21697680 |
| fathers' intentions to accept human papillomavirus vaccination for sons and daughters: exploratory findings from rural honduras. | objectives: little is known about fathers' attitudes toward human papillomavirus (hpv) vaccination in low-resource settings. we sought to determine the awareness of hpv vaccination among honduran fathers, and to assess their intention to accept hpv vaccination for their sons and daughters. methods: we conducted 100 structured interviews of fathers recruited from medical and business settings between may 2007 and june 2008. after assessing baseline knowledge, fathers received a brief explanation ... | 2011 | 21698492 |
| implication of human papillomavirus-66 in vulvar carcinoma: a case report. | abstract: | 2011 | 21702970 |
| alaska native adolescent views on cervical cancer, the human papillomavirus (hpv), genital warts and the quadrivalent hpv vaccine. | to understand the knowledge levels, attitudes and perceptions of alaska native adolescent girls about cervical cancer, hpv, genital warts and the hpv vaccine. | 2011 | 21703130 |
| performance of the quantitative food frequency questionnaire used in the brazilian center of the prospective study natural history of human papillomavirus infection in men: the him study. | the natural history of human papillomavirus (hpv) infection in men: the him study is a prospective multicenter cohort study that, among other factors, analyzes participants' diet. a parallel cross-sectional study was designed to evaluate the validity and reproducibility of the quantitative food frequency questionnaire (qffq) used in the brazilian center from the him study. for this, a convenience subsample of 98 men aged 18 to 70 years from the him study in brazil answered three 54-item qffq and ... | 2011 | 21703383 |
| c-t variant in a mirna target site of bcl2 is associated with increased risk of human papilloma virus related cervical cancer-an in silico approach. | micrornas control gene expression at the posttranscriptional level by base-pairing to the 3'-utr of their target mrnas, thus leading to mrna degradation of protein fabrication. we hypothesize, snps within mirnas and their targets could be of significance to an individual's risk of developing cancer. we analyzed in silico snp information on cervical cancer associated aberrant alleles and further investigated this in a case-control study by examining eleven snps from different genes. it was observ ... | 2011 | 21704150 |
| efficient dna extraction for hpv genotyping in formalin-fixed, paraffin-embedded tissues. | dna from archived ffpe can be used for papillomavirus genotyping, but potential problems include paraffin as a physical barrier, dna cross-linking, and pcr inhibitors. to address these complications, we combined a commercially available dna isolation kit (qiagen dneasy) with a heat treatment and evaluated the resulting dna with regards to hpv typing. dna was extracted from 10-++m sections from 150 ffpe cancer samples. one protocol followed the manufacturer's recommendation, including paraffin re ... | 2011 | 21704270 |
| see-and-treat approaches to cervical cancer prevention for hiv-infected women. | cervical cancer remains the second commonest cancer among women worldwide, and more than 85% of the global burden of this disease occurs in the developing world. hiv-infected women have a higher likelihood of developing persistent high-risk human papillomavirus (hpv) infection, precancer, and invasive cervical cancer than seronegative women. although highly effective primary and secondary prevention strategies are currently available, they remain inaccessible to the vast majority of women. becau ... | 2011 | 21706187 |
| the value of high-resolution anoscopy in the diagnosis of anal cancer precursor lesions in hiv-positive patients. | anal cancer, although a still rare disease, is being observed in ascending rates among some population segments known to be at risk for the development of the disease. human papillomavirus (hpv) infection, immunodepression and anal intercourse are some factors associated with the development of the malignancy. its similarities to cervical cancer have led to many studies aiming to establish guidelines for detecting and treating precursor lesions of anal cancer, with the goal of prevention. high-r ... | 2011 | 21709956 |
| safety and reactogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, 18) l1 viral-like-particle vaccine in older adolescents and young adults. | prophylactic vaccination with a quadrivalent hpv (types 6, 11, 16, 18) vaccine (qhpv) has been shown to prevent infection with hpv 6/11/16/18 and associated disease in women and more recently, in men. here we report on the safety and reactogenicity of the qhpv vaccine in males. a total of 4,065 healthy males aged 16-26 years were enrolled into a randomized, placebo-controlled, double-blind trial. subjects were randomized 1:1 to receive qhpv vaccine or placebo at day 1, month 2, and month 6. safe ... | 2011 | 21712645 |
| dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions. | human papilloma virus (hpv)-related warts persist, evading host immune surveillance, but sometimes disappear with inflammation. | 2011 | 21715145 |
| mother-daughter communication and college women's confidence to communicate with family members and doctors about the human papillomavirus and sexual health. | in this study, we examined whether mother-daughter sexuality communication in midadolescence contributes to young women's self-efficacy to consult with family members about sexual health problems, and to talk with physicians about the human papillomavirus (hpv). | 2011 | 21715198 |
| p63 is necessary for the activation of human papillomavirus late viral functions upon epithelial differentiation. | the late phase of the human papillomavirus (hpv) life cycle is linked to epithelial differentiation, and we investigated the factors that regulate this process. one potential regulator is p63, a member of the p53 family of proteins, which modulates epithelial development, as well as proliferation capability, in stem cells. in this study, we examined the role of p63 in the hpv life cycle using a lentiviral knockdown system for p63. in epithelial cells, the δn truncated isoforms of p63 predominate ... | 2011 | 21715473 |
| high-risk hpv dna testing and hpv-16/18 genotyping: what is the clinical application? | there are currently 2 tests approved for clinical use that nonspecifically detect the presence of multiple oncogenic or high-risk human papillomavirus (hpv) types. one hpv genotyping test is also available for use that specifically detects the presence of high-risk hpv types 16 and 18. the purpose of this review was to evaluate the clinical performance of these hpv dna tests and the utility of the tests within current screening recommendations. | 2011 | 21716051 |
| human papillomavirus genotypes in male genitalia and their concordance among pregnant spouses participating in the finnish family hpv study. | introduction.ôçé genotype-specific concordance among human papillomavirus (hpv)-infected spouses is incompletely assessed. hpv concordance is of importance in counselling hpv-infected subjects and their partners. aim.ôçé to determine hpv-genotype distribution and prevalence in semen and urethral samples of young fathers and their concordance with hpv-genotypes in cervical and oral mucosal samples of their spouses. methods.ôçé in the finnish family hpv study, urethral and semen samples were colle ... | 2011 | 21718450 |
| rate of detection of high-risk hpv with two assays in womenôëñ30years of age. | high-risk (hr) human papillomavirus (hpv) prevalence rates, as determined by the cervista(-«) hpv hr test, in women aged ôëñ30 years in a routine screening population have not been studied. | 2011 | 21724457 |
| prevalence of human papillomavirus (hpv) types in cervical cancer 2003-2008 in stockholm, sweden, before public hpv vaccination. | abstract background. human papillomavirus (hpv) infection is the major cause of cervical cancer, but the prevalence of different hpv types varies depending on geographical location and may change dramatically after introduction of hpv vaccination. here, we aimed to gain some information regarding the recent prevalence of different hpv types, in cancer of the uterine cervix in the stockholm region, before the introduction of public hpv vaccination in sweden. material and methods. from 215 diagnos ... | 2011 | 21726177 |
| Promoter methylation analysis of WNT/+¦-catenin signaling pathway regulators to detect adenocarcinoma or its precursor lesion of the cervix. | Cervical adenocarcinoma (AdCA) and adenocarcinoma in situ (ACIS) are frequently missed in cytology-based screening programs. Testing for high-risk human papillomavirus (hrHPV) improves their detection, but novel ACIS/AdCA specific biomarkers are needed to increase specificity for these lesions. Novel markers may be deduced from the WNT/+¦-catenin signaling pathway, which is aberrantly activated during cervical carcinogenesis. | 2011 | 21726894 |
| a randomized clinical comparative study of cryotherapy plus photodynamic therapy vs. cryotherapy in the treatment of multiple condylomata acuminata. | cryotherapy cannot destroy subclinical human papillomavirus-infected cells of condylomata acuminata (ca). the topical application of aminolevulinic acid (ala) results in a shallow penetration depth in ca lesions (1). | 2011 | 21729164 |
| human papillomavirus vaccination uptake and factors related to uptake in a traditional desert city in the united arab emirates. | it is important to assess uptake of a new vaccine. the present survey estimated the uptake of the recently introduced human papillomavirus vaccine (hpvv) in the emirate of abu dhabi and also explored barriers to uptake. a questionnaire survey was conducted in secondary schools, enrolling 334 girls. the uptake percentage was estimated and factors associated with uptake were assessed with multilevel logistic regression. crude vaccination uptake was 53%. factors positively associated with uptake we ... | 2011 | 21729960 |
| induction of human +¦-defensins and psoriasin in vulvovaginal human papillomavirus-associated lesions. | infections with a low-risk type of human papillomavirus (hpv) may lead to genital warts. hpv targets the basal cell layer of epithelial cells. the first line of defense is the innate immune system, which provides nonspecific protection against a variety of pathogens. the antimicrobial peptides (amps) +¦- and +¦-defensins, cathelicidins, psoriasin, and rnase7 are central mediators. | 2011 | 21730203 |
| the changing picture of high-grade anal intraepithelial neoplasia in men who have sex with men: the effects of 10 years of experience performing high-resolution anoscopy. | ten years ago, we published findings from anal dysplasia screening in a metropolitan surgical practice where the majority of men who have sex with men had biopsy-proven high-grade anal intraepithelial neoplasia. | 2011 | 21730790 |
| cervical cancer treatment in africa. | this review is to inform the reader about the current situation with regard to treatment of cervical cancer in africa and the barriers and complexities faced in most african countries. it also reviews the natural history of cervical cancer, the new 2009 international federation of gynecology and obstetrics staging, and current treatment guidelines for cervical cancer. | 2011 | 21734579 |
| a semliki forest virus vector engineered to express ifn+¦ induces efficient elimination of established tumors. | semliki forest virus (sfv) represents a promising gene therapy vector for tumor treatment, because it produces high levels of recombinant therapeutic proteins while inducing apoptosis in infected cells. in this study, we constructed a sfv vector expressing murine interferon alpha (ifn+¦). ifn+¦ displays antitumor activity mainly by enhancing an antitumor immune response, as well as by a direct antiproliferative effect. in spite of the antiviral activity of ifn+¦, sfv-ifn could be produced in bhk ... | 2011 | 21734727 |
| human papillomavirus serologic follow-up response and relationship to survival in head and neck cancer: a case-comparison study. | abstract: | 2011 | 21740566 |
| incremental impact of adding boys to current human papillomavirus vaccination programs: role of herd immunity. | our aim was to examine the potential incremental impact of vaccinating boys against human papillomavirus (hpv) on vaccine-type infection in females and males, using an individual-based hpv transmission-dynamic model. under base assumptions (vaccine efficacy = 99%, duration of protection = 20 years, coverage = 70%), vaccinating 12-year-old boys, in addition to girls, resulted in an incremental reduction in hpv-16/18 (hpv-6/11) incidence over 70 years of 16% (3%) in females and 23% (4%) in males. ... | 2011 | 21742835 |
| until which age should women be vaccinated against hpv infection? recommendation based on cost-effectiveness analyses. | cervical cancer is caused by infection with human papillomavirus (hpv). several countries have implemented vaccination programs against hpv for teenage girls before sexual debut. however, recent clinical trials have demonstrated that vaccination of older women is highly effective as well. accordingly, it has been suggested that these older women should also be offered vaccination. here, the cost-effectiveness of hpv vaccination for older women was assessed. | 2011 | 21742836 |
| an examination of male and female odds ratios by bmi, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies. | greater tobacco smoking and alcohol consumption and lower body mass index (bmi) increase odds ratios (or) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ors for these factors. | 2011 | 21744095 |
| oral hpv infection and sexuality: a cross-sectional study in women. | human papillomavirus (hpv) is the main risk factor for cervical cancers and is associated with close to 36% of oropharyngeal cancers. there is increasing evidence that oral hpv transmission is related to sexual behavior but to our knowledge studies that involve women who have sex with women have not been performed. we examined the prevalence of oral hpv according to sexual behavior among a population-based sample of 118 women and have made some inferences of possible predictors of oral hpv infec ... | 2011 | 21747715 |
| incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients. | abstract: background: renal allograft recipients are reported to have a higher incidence of malignancy than the general population. this single hospital-based study examined the incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients. methods: among 453 women receiving renal transplantation from january 1990 to december 2008, 5 patients were diagnosed with cervical carcinoma. medical records of these 5 patients were retrospectively reviewed, and clin ... | 2011 | 21752252 |
| self-sample hpv-tests as an intervention for non-atteendees of cervical cancer screening in finland: a randomised study. | background: attendance in screening is an important determinant of cervical cancer. previous experience on high-risk human papillomavirus (hrhpv) dna testing on patient-obtained samples suggests a good effect among non-attendees of screening. we assessed the effects of self-sampling on attendance in the finnish screening programme.methods: non-attendees after the primary invitation in one municipality (espoo) were randomised to receive either a self-sampling kit (2,397 women) or an extra invitat ... | 2011 | 21752985 |
| human papillomavirus: science and technologies for the elimination of cervical cancer. | introduction: academic research has made a significant advancement in understanding the viral causes of cervical cancer and generating the technology for prevention, both at the primary and secondary levels. human papillomaviruses (hpvs) have been recognized as the first necessary cause of cervical cancer, the second most common cancer in women worldwide. areas covered: this paper reviews the epidemiological evidence of the causality of hpv in relation to cervical cancer, other genital tract can ... | 2011 | 21756205 |
| higher incidence and persistence of high-risk human papillomavirus infection in female sex workers compared with women attending family planning. | background: there are no data on the incidence and persistence of high-risk human papillomavirus (hr-hpv) infections in female sex workers (fsws). we aimed to describe and compare the rates of incidence and persistence of hr-hpv infections in fsws and women from the general population (wgp) who attended healthcare facilities between may 2003 and december 2006 in alicante, spain. methods: women with an established hr-hpv infection at study entry were evaluated for the analysis of hr-hpv persisten ... | 2011 | 21757383 |
| human papillomavirus type 18 chimeras containing the l2/l1 capsid genes from evolutionarily diverse papillomavirus types generate infectious virus. | papillomaviruses (pvs) comprise a large family of viruses infecting nearly all vertebrate species, with more than 100 human pvs identified. our previous studies showed that a mutant chimera hpv18/16 genome, consisting of the upper regulatory region and early orfs of hpv18 and the late orfs of hpv16, was capable of producing infectious virus in organotypic raft cultures. we were interested in determining whether the ability of this chimeric genome to produce infectious virus was the result of hpv ... | 2011 | 21762735 |
| skin tumor formation in human papillomavirus 8 transgenic mice is associated with a deregulation of oncogenic mirnas and their tumor suppressive targets. | background: dysregulation of microrna (mirna) expression is regularly found in various types of cancer and contributes to tumorigenic processes. however, little is known about mirna expression in non-melanoma skin cancer in which a pathogenic role of beta human papillomaviruses (hpv) is discussed. a carcinogenic potential of beta hpv8 could be demonstrated in a transgenic mouse model, expressing all early genes of hpv8 (hpv8-cer). a single uva/b-dose induced oncogene expression and led to papill ... | 2011 | 21763111 |
| new human papillomavirus (hpv) types involved in epidermodysplasia verruciformis (ev) in 3 hiv-infected patients: response to topical cidofovir. | 2011 | 21763546 | |
| human papillomavirus genotype distribution in czech women and men with diseases etiologically linked to hpv. | the hpv prevalence and genotype distribution are important for the estimation of the impact of hpv-based cervical cancer screening and hpv vaccination on the incidence of diseases etiologically linked to hpvs. the hpv genotype distribution varies across different geographical regions. therefore, we investigated the type-specific hpv prevalence in czech women and men with anogenital diseases. | 2011 | 21765924 |
| the first international standard for antibodies to hpv 16. | current hpv vaccines and vaccine candidates are based on recombinant virus capsid proteins, so called virus-like particles (vlps). standardisation of assays for hpv capsid antibody will assist with epidemiology studies and future vaccine development. a world health organization international collaborative study was undertaken to assess the suitability of a freeze-dried serum, obtained from women naturally infected with hpv 16 and reactive against hpv 16 only, to serve as the international standa ... | 2011 | 21767589 |
| small molecule inhibitors of human papillomavirus protein - protein interactions. | human papillomaviruses (hpv) have now been identified as a necessary cause of benign and malignant lesions of the differentiating epithelium, particularly cervical cancer, the second most prevalent cancer in women worldwide. while two prophylactic hpv vaccines and screening programs are available, there is currently no antiviral drug for the treatment of hpv infections and associated diseases. the recent progress toward the identification and characterization of specific molecular targets for sm ... | 2011 | 21769307 |
| incomplete knowledge - unclarified roles in sex education: results of a national survey about human papillomavirus infections. | marek e., dergez t., bozsa s., gocze k., rebek-nagy g., kricskovics a., kiss i., ember i. & gocze p. (2011) european journal of cancer care. incomplete knowledge - unclarified roles in sex education: results of a national survey about human papillomavirus infections the purpose of this study was to evaluate the awareness of human papillomavirus (hpv) infections both in male and female adults in hungary. a self-administered, anonymous questionnaire was completed by 785 college students and parent ... | 2011 | 21771125 |
| histopathologic follow-up and human papillomavirus dna test results in 290 patients with high-grade squamous intraepithelial lesion papanicolaou test results. | background: the study documents histopathologic outcomes and high-risk (hr) human papillomavirus (hpv) test results in a large cohort of patients with high-grade squamous intraepithelial lesion (hsil) liquid-based cytology (lbc) pap test results. methods: a total of 352 patients with hsil results (338 cervical and 14 vaginal) who had hrhpv testing and 290 patients with biopsy follow-up were studied. hrhpv detection rates were compared at different ages, with or without an endocervical/transforma ... | 2011 | 21774093 |
| emerging theme: cellular pdz proteins as common targets of pathogenic viruses. | more than a decade ago three viral oncoproteins - adenovirus type 9 e4-orf1, human t-lymphotropic virus type 1 tax, and high-risk human papillomavirus e6 - were found to encode a related carboxyl-terminal pdz domain-binding motif (pbm) that mediates interactions with a select group of cellular pdz proteins. recent studies have shown that many other viruses also encode pbm-containing proteins that bind to cellular pdz proteins. interestingly, these recently recognized viruses include not only som ... | 2011 | 21775458 |
| integration of human papillomavirus correlates with high levels of viral oncogene transcripts in cervical carcinogenesis. | a prospective, cross-sectional study was conducted to investigate the correlation between the integration of high-risk human papillomavirus and disease severity of cervical lesions. 720 liquid-based cytology specimens including 422 normal cytology, 78 low-grade squamous intraepithelial lesions, 172 high-grade squamous intraepithelial lesions, and 48 women with cervical cancers were examined using hpv blot and type-specific e6 pcr. positive hpv dna types 16, 18, 52 and 58 were examined for viral ... | 2011 | 21777630 |
| psychological responses of women infected with cervical human papillomavirus: a qualitative study in taiwan. | to determine the psychological response of cervical human papillomavirus (hpv) infected women. | 2011 | 21791300 |