Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| fam5c contributes to aggressive periodontitis. | aggressive periodontitis is characterized by a rapid and severe periodontal destruction in young systemically healthy subjects. a greater prevalence is reported in africans and african descendent groups than in caucasians and hispanics. we first fine mapped the interval 1q24.2 to 1q31.3 suggested as containing an aggressive periodontitis locus. three hundred and eighty-nine subjects from 55 pedigrees were studied. saliva samples were collected from all subjects, and dna was extracted. twenty-one ... | 2010 | 20383335 |
| cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol. | cytolethal distending toxins (cdts) are tripartite protein exotoxins produced by a diverse group of pathogenic gram-negative bacteria. based on their ability to induce dna damage, cell cycle arrest, and apoptosis of cultured cells, cdts are proposed to enhance virulence by blocking cellular division and/or directly killing epithelial and immune cells. despite the widespread distribution of cdts among several important human pathogens, our understanding of how these toxins interact with host cell ... | 2010 | 20385557 |
| targeted delivery of a photosensitizer to aggregatibacter actinomycetemcomitans biofilm. | the ability to selectively target specific biofilm species with antimicrobials would enable control over biofilm consortium composition, with medical applications in treatment of infections on mucosal surfaces that are colonized by a mixture of beneficial and pathogenic microorganisms. we functionalized a genetically engineered multimeric protein with both a targeting moiety (biotin) and either a fluorophore or a photosensitizer (snce6). biofilm microcolonies of aggregatibacter actinomycetemcomi ... | 2010 | 20385858 |
| [effect of periodontal mechanical treatment on periodontal pathogenic bacteria in gingival crevicular fluid of chronic periodontitis patients]. | to evaluate the subgingival prevalent rates of 6 periodontal pathogenic bacteria in gingival crevicular fluids of cp patients before and after treatment, to analyze the relationship between the prevalent variance and periodontal clinical parameters, and to provide a microbiologic method of evaluating curative effect and estimating the prognosis. | 2010 | 20396365 |
| [clinical significance of the change in serum igg titers respond to aggregatibacter actinomycetemcomitans in chronic periodontitis patients]. | to characterize serum antibody response to aggregatibacter actinomycetemcomitans (aa) serotype c in chronic periodontitis (cp) patients, and to observe the correlation of igg titer with clinical parameters. | 2010 | 20396366 |
| autoinducer-2 and qsec control biofilm formation and in vivo virulence of aggregatibacter actinomycetemcomitans. | biofilm formation by the periodontal pathogen aggregatibacter actinomycetemcomitans is dependent upon autoinducer-2 (ai-2)-mediated quorum sensing. however, the components that link the detection of the ai-2 signal to downstream gene expression have not been determined. one potential regulator is the qsebc two-component system, which is part of the ai-2-dependent response pathway that controls biofilm formation in escherichia coli. here we show that the expression of qsebc in a. actinomycetemcom ... | 2010 | 20404080 |
| involvement of adhesion molecule in in vitro plaque-like formation of macrophages stimulated with aggregatibacter actinomycetemcomitans lipopolysaccharide. | inflammatory agents, such as lipopolysaccharide (lps), in periodontal pockets may promote atherogenesis by activating leukocytes. in our previous study, we developed a microchannel chip to observe the cell adhesion process in a fluid system. the objective of this investigation was to examine the mechanism by which periodontopathic bacterial lps enhances plaque-like formation on a microchannel chip. | 2010 | 20412415 |
| periodontitis and arthritis interaction in mice involves a shared hyper-inflammatory genotype and functional immunological interferences. | periodontitis (pd) and rheumatoid arthritis (ra) have been found to be clinically associated and to share the chronic nature of the inflammatory reaction associated with bone resorption activity. however, the mechanisms underlying such association are unknown. therefore, we examined the basis of actinobacillus actinomycetemcomitans- and porphyromonas gingivalis-induced pd and pristane-induced arthritis (pia) interaction in mice. higher severity pd in the genetically inflammation prone acute infl ... | 2010 | 20428191 |
| clinical and microbiologic follow-up evaluations after non-surgical periodontal treatment with erbium:yag laser and scaling and root planing. | this study compared erbium-doped: yttrium, aluminum, and garnet (er:yag) laser irradiation (100 mj/pulse; 10 hz; 12.9 j/cm(2)) with or without conventional scaling and root planing (srp) to srp only for treatment of periodontal pockets. | 2010 | 20429647 |
| antimicrobial activity of the naja atra cathelicidin and related small peptides. | we have identified an 11-residue pattern (kr(f/a)kkffkk(l/p)k), which we have named the atra motif, within the sequence of the chinese cobra (naja atra) cathelicidin. a series of 11-residue peptides (atra-1, -2, -1a and -1p) were designed to probe the significance of the conserved residues within the atra motif, and their contributions to antimicrobial performance. the antimicrobial activities of the peptides were assessed against escherichia coli k12 strain and aggregatibacter actinomycetemcomi ... | 2010 | 20438706 |
| pcr detection of streptococcus mutans and aggregatibacter actinomycetemcomitans in dental plaque samples from haitian adolescents. | streptococcus mutans and aggregatibacter actinomycetemcomitans are oral pathogens associated with dental caries and periodontitis, respectively. the aim of this study was to determine the colonization of these two microorganisms in the dental plaque of a group of haitian adolescents using two different polymerase chain reaction (pcr) methods, standard pcr, and quantitative real-time pcr (qpcr) assays. fifty-four pooled supra-gingival plaque samples and 98 pooled sub-gingival plaque samples were ... | 2010 | 20446101 |
| short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis. | the aim of this study was to evaluate the clinical and microbiological effects of scaling and root planing (srp) alone or combined with metronidazole (mtz) and amoxicillin (amx) in the treatment of subjects with generalized aggressive periodontitis (gagp). | 2010 | 20447259 |
| communication: antimicrobial activity of smap28 with a targeting domain for porphyromonas gingivalis. | antibiotic therapy is often used with mechanical therapy to treat periodontal disease. however, complications associated with antibiotic use can occur. a 'bacteria-specific' targeted approach would eliminate some of these complications and kill specific periodontopathogens without harming the commensal bacteria. one such approach is to couple antimicrobial peptides to a ligand, pheromone, or antibody specific for the periodontopathogen, porphyromonas gingivalis. to assess the feasibility of this ... | 2010 | 20454638 |
| efficient synthesis of a 6-deoxytalose tetrasaccharide related to the antigenic o-polysaccharide produced by aggregatibacter actinomycetemcomitans serotype c. | concise synthesis of a 6-deoxy-alpha-l-talose tetrasaccharide, 6-deoxy-alpha-l-talp-(1-->3)-6-deoxy-alpha-l-talp-(1-->2)-6-deoxy-alpha-l-talp-(1-->3)-6-deoxy-alpha-l-talp, the dimer of the disaccharide repeating unit of the ops from aggregatibacter actinomycetemcomitans serotype c, has been accomplished through suitable protecting group manipulations and stereoselective glycosylation starting from commercially available l-rhamnose. the target oligosaccharide in the form of its p-methoxyphenyl gl ... | 2010 | 20457448 |
| subtle bacterial endocarditis due to kingella kingae in an infant: a case report. | a 9-month-old infant presented with fever, dyspnoea, and a murmur. echocardiography showed a mitral vegetation with significant regurgitation. mitral valve plasty was performed on day 6, and was polymerase chain reaction positive for kingella kingae. the cardiac outcome was favourable. this case illustrates a subtle presentation of k. kingae mitral valve infective endocarditis in a normal-cardaic infant, treated with early surgery, and the agent belonged to the hacek (haemophilus spp actinobacil ... | 2010 | 20465860 |
| transcriptional activation of the tad type ivb pilus operon by pypb in yersinia enterocolitica. | type iv pili are virulence factors in various bacteria and mediate, among other functions, the colonization of diverse surfaces. various subclasses of type iv pili have been identified, but information on pilus expression, biogenesis, and the associated phenotypes is sparse for the genus yersinia. we recently described the identification of pypb as a transcriptional regulator in yersinia enterocolitica. here we show that the pypb gene is associated with the tad locus, a genomic island that is wi ... | 2010 | 20472801 |
| aggregatibacter actinomycetemcomitans accelerates atherosclerosis with an increase in atherogenic factors in spontaneously hyperlipidemic mice. | cariogenic and periodontal pathogens are thought to be etiological factors in the development of cardiovascular disease. we assessed the involvement of the periodontal pathogen aggregatibacter actinomycetemcomitans and cariogenic pathogen streptococcus mutans in the development of atherosclerosis in apolipoprotein e-deficient spontaneously hyperlipidemic (apoe(shl)) mice. the mice were treated intravenously with a. actinomycetemcomitans hk1651, s. mutans gs-5, or phosphate-buffered saline three ... | 2010 | 20482627 |
| competition between yogurt probiotics and periodontal pathogens in vitro. | to investigate the competition between probiotics in bio-yogurt and periodontal pathogens in vitro. | 2010 | 20491536 |
| repression of aerobic leukotoxin transcription by integration host factor in aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans has been implicated as the primary etiologic agent in localized aggressive periodontitis. this bacterium produces a leukotoxin which may help the bacterium evade the host immune response. leukotoxin transcription is induced when a. actinomycetemcomitans is grown anaerobically, as in the periodontal pocket. previously, a 35 bp oxygen-response-element (ore) was shown to be responsible for oxygen regulation at the leukotoxin promoter. however, the gene's transc ... | 2010 | 20493253 |
| [multiple aggregatibacter actinomycetemcomitans skin abscesses]. | 2010 | 20493650 | |
| identification of immunological parameters associated with the alveolar bone level in periodontal patients. | the present study was performed to clarify the relationship between periodontal disease severity and selected immunological parameters consisting of serum igg titer against periodontopathogenic bacteria, the expression of the helper t-cell cytokine by gingival mononuclear cells, and patients' immunoreactivity to cross-reactive heat shock protein (hsp) epitope peptide from p. gingivalis hsp60. | 2010 | 20498762 |
| effects of resveratrol on expression of vascular endothelial growth factor in human gingival fibroblasts stimulated by periodontal pathogens. | to investigate the effects of resveratrol, a naturally occurring polyphenol, on the expression of vascular endothelial growth factor (vegf) in human gingival fibroblast culture in response to vesicles and outer membrane proteins from periodontopathic bacteria. | 2010 | 20507262 |
| the recolonization hypothesis in a full-mouth or multiple-session treatment protocol: a blinded, randomized clinical trial. | to test recolonization of periodontal lesions after full-mouth scaling and root planing (fm-srp) or multiple session-srp (ms-srp) in a randomized clinical trial and whether fm-srp and ms-srp result in different clinical outcomes. | 2010 | 20507375 |
| mechanical non-surgical treatment of peri-implantitis: a single-blinded randomized longitudinal clinical study. ii. microbiological results. | peri-implantitis is common in patients with dental implants. we performed a single-blinded longitudinal randomized study to assess the effects of mechanical debridement on the peri-implant microbiota in peri-implantitis lesions. | 2010 | 20507380 |
| effects of a composition containing lactoferrin and lactoperoxidase on oral malodor and salivary bacteria: a randomized, double-blind, crossover, placebo-controlled clinical trial. | we report a clinical trial of the effects of test tablets containing bovine lactoferrin and lactoperoxidase on oral malodor and salivary bacteria. fifteen subjects with volatile sulfur compounds (vscs) in mouth air above the olfactory threshold (h(2)s >1.5 or ch(3)sh >0.5 ng/10 ml) as detected by gas chromatography were enrolled in the trial. either a test or a placebo tablet was ingested twice at 1-h intervals in two crossover phases. mouth air was monitored for vsc levels at the baseline befor ... | 2010 | 20512389 |
| gram-negative periodontal bacteria induce the activation of toll-like receptors 2 and 4, and cytokine production in human periodontal ligament cells. | periodontitis is a bacterially induced chronic inflammatory disease. toll-like receptors (tlrs), which could recognize microbial pathogens, are important components in the innate and adaptive immune systems. both qualitatively and quantitatively distinct immune responses might result from different bacteria stimulation and the triggering of different tlrs. this study explores the interaction of porphyromonas gingivalis, prevotella intermedia, fusobacterium nucleatum, and aggregatibacter actinomy ... | 2010 | 20528699 |
| characterization of a new serotype g isolate of aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans is usually isolated from the oral cavity where it is associated with active periodontitis. the species can be divided into six serotypes (a-f) according to their surface carbohydrate antigens. however, some clinical isolates cannot be grouped within these six serotypes. gram-negative, facultative anaerobic, catalase-positive coccobacilli were isolated from a patient with periodontitis and identified by employing genetic, biochemical and serological analyses. ... | 2010 | 20536747 |
| occurrence of aggregatibacter actinomycetemcomitans serotypes in subgingival plaque from united states subjects. | this study examined the distribution pattern of aggregatibacter actinomycetemcomitans serotypes in the subgingival plaque of subjects residing in the united states. a. actinomycetemcomitans was identified in 256 subgingival plaque samples from 161 subjects. for 190 of the 256 samples, the total cultivable bacteria and selected periodontal pathogenic species were determined. a. actinomycetemcomitans isolates were confirmed by a16s rdna-based pcr analysis, genotyped by arbitrarily-primed pcr, and ... | 2010 | 20536748 |
| periodontopathic bacteria and herpesviruses in chronic periodontitis. | periodontal disease involves complex interactions of microorganisms and host defenses. this work investigated the associations between putative bacterial pathogens, herpesviruses and chronic periodontitis. subgingival samples were collected from 40 periodontally healthy individuals and from 40 patients with chronic periodontitis with probing depths of < or =3 mm or > or =6 mm. multiplex and nested polymerase chain reactions were used to identify bacterial pathogens and herpesviruses. porphyromon ... | 2010 | 20536751 |
| antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. | this study is to assess the antibacterial activity of omega-6, -7, -9 (n-6, n-7, n-9) fatty acids against various oral microorganisms. | 2010 | 20541177 |
| levels of aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, inflammatory cytokines and species-specific immunoglobulin g in generalized aggressive and chronic periodontitis. | aggressive periodontitis pathogenesis still is not completely understood in the literature regarding the relationship between microbial and inflammatory aspects. so this study aimed to compare microbial and inflammatory patterns in the gingival crevicular fluid of generalized aggressive and chronic periodontitis patients. | 2010 | 20546109 |
| antibiotic resistance of subgingival species in chronic periodontitis patients. | the increasing rate of resistance of microorganisms to penicillin and other antibiotics has generated concern among health authorities in latin america. the present investigation determined the in vitro susceptibility of porphyromonas gingivalis, fusobacterium nucleatum, black-pigmented prevotella spp. and aggregatibacter actinomycetemcomitans to metronidazole, amoxicillin, amoxicillin/clavulanic acid, clindamycin and moxifloxacin in patients with chronic periodontitis. | 2010 | 20546113 |
| determinants of serum igg responses to periodontal bacteria in a nationally representative sample of us adults. | to assess the distribution of elevated antibody titres to multiple periodontal bacteria, including established/putative pathogens and health-related species, by selected demographic, behavioural, and oral- and general health-related characteristics. | 2010 | 20561113 |
| anti-phosphorylcholine-opsonized low-density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells. | epidemiological and animal studies suggest that periodontal infections increase atherosclerosis risk. periodontitis patients have elevated levels of anti-phosphorylcholine (anti-pc) reactive not only with numerous periodontal organisms but also with minimally modified low-density lipoprotein (mmldl). dendritic cells (dcs) reside in arterial walls and accumulate in atherosclerotic lesions. the ability of anti-pc to bind mmldl prompted the hypothesis that opsonized mmldl would stimulate dcs and en ... | 2010 | 20572914 |
| comprehensive treatment of periodontitis in patients with von willebrand disease. | hemophilia a and b and von willebrand disease (vwd) belong to the most frequent congenital coagulation disorders and are a significant problem in patients who require periodontal therapy or tooth extraction. these patients need specialist management because even minor invasive procedures can precipitate a prolonged bleeding episode. however, although dental care presents major challenges in these patients, only a few studies are available. | 2010 | 20594049 |
| adaptive immune response in osteoclastic bone resorption induced by orally administered aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. | there is mounting evidence that innate and adaptive immunity are critical for periodontal disease-mediated bone resorption. these studies examined the role of b and cd4 t cells in adaptive immunity of rats infected with aggregatibacter actinomycetemcomitans (aa). sprague-dawley male rats were fed aa-containing mash or control-mash for 2 weeks. b and cd4 t cells were obtained from draining lymph nodes at 2, 4 and 12 weeks, postinoculation. quantitative polymerase chain reaction-based messenger rn ... | 2010 | 20618701 |
| [study on the counting of streptococcus mutans, streptococcus sanguis, haemophilus actinomycetemcomitans by methyl thiazolyl tetrazolium colorimetric method]. | to explore the feasibility of methyl thiazolyl tetrazolium (mtt) colorimetric method and the applied condition for the normal bacteria in the mouth, as streptococcus mutans (s. mutans), streptococcus sanguis (s. sanguis), haemophilus actinomycetemcomitans (h. actinomycetemcomitans). | 2010 | 20635664 |
| regulatory t cells attenuate experimental periodontitis progression in mice. | the aim of this study was to identify the presence and characterize the function of regulatory t cells (tregs) in experimental periodontitis in mice. | 2010 | 20642629 |
| examination of periodontal pathogens in stenotic valve specimens and in whole blood samples in patients affected by aortic valve stenosis and chronic periodontitis. | periodontitis may be a risk factor for atherosclerosis and coronary heart disease. the influence of periodontal pathogens in cardiovascular diseases needs further investigation. therefore, the aims of this clinical study are: to test the presence of periodontal bacteria dna in aortic valves and to assess the concomitant presence of the same periodontal bacteria dna in whole blood samples in patients affected by aortic valve stenosis and chronic periodontitis. nineteen consecutive patients (12 ma ... | 2010 | 20646351 |
| comparative study of methylene blue and erythrosine dyes employed in photodynamic therapy for inactivation of planktonic and biofilm-cultivated aggregatibacter actinomycetemcomitans. | the proposal of this work was to test the efficacy of photodynamic therapy (pdt) by using methylene blue (mb) and erythrosine (ery) to inactivate aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans), the main pathogen in aggressive periodontitis. | 2010 | 20649431 |
| phylogenetic variation of aggregatibacter actinomycetemcomitans serotype e reveals an aberrant distinct evolutionary stable lineage. | the periodontal pathogen aggregatibacter actinomycetemcomitans that comprises six serotypes (a-f), is often identified by pcr-based techniques targeting the 16s rrna gene. in this study, 16s rrna gene sequence analysis revealed an aberrant cluster of 19 strains within serotype e, denoted as serotype e'. the 16s rrna gene sequence similarities found between serotype e' strains ranged from 99.7% to 100.0%, whereas 96.8-97.5% sequence similarity was obtained with members of the other serotypes, ind ... | 2010 | 20654735 |
| characterization of the normal bacterial flora in peri-implant sulci of partially and completely edentulous patients. | to characterize the normal bacterial flora and evaluate the presence of periodontopathogenic bacteria around dental implants and to correlate them with the periodontal flora or, in completely edentulous patients, the alveolar gingival flora. | 2010 | 20657863 |
| occurrence of aggregatibacter actinomycetemcomitans in brazilians with chronic periodontitis. | studies have suggested that a. actinomycetemcomitans is involved in the aetiology of aggressive periodontitis as well as in chronic periodontitis. this study was aimed at elucidating the occurrence of a. actinomycetemcomitans in a brazilian population with chronic periodontitis. a total of 555 (mean age 33.04 +/- 12.45) individuals, living in two large areas of the são paulo state, namely "baixada santista" and "vale do paraíba", and diagnosed with mild [180 (mean age 29.59 +/- 10.94)], moderate ... | 2010 | 20658042 |
| microbiota around teeth and dental implants in periodontally healthy, partially edentulous patients: is pre-implant microbiological testing relevant? | this study aimed to assess the prevalence of seven periodontal marker pathogens, before implant placement and 1 yr after loading, in periodontally healthy individuals and to assess the long-term effectiveness of pre-implant reduction of pathogens to below threshold levels. in 93 individuals needing single tooth replacement, pooled subgingival microbiological samples from standard sites were cultured and analyzed before implant treatment and 1 yr after loading. threshold levels commonly used in p ... | 2010 | 20662908 |
| energy dose parameters affect antimicrobial photodynamic therapy-mediated eradication of periopathogenic biofilm and planktonic cultures. | this study evaluated the in vitro efficacy of a commercially available apdt system in eradication of the periopathogens porphyromonas gingivalis, fusobacterium nucleatum, and aggregatibacter actinomycetemcomitans in both planktonic and biofilm cultures. | 2010 | 20666581 |
| cloning and in vitro characterization of dtdp-6-deoxy-l-talose biosynthetic genes from kitasatospora kifunensis featuring the dtdp-6-deoxy-l-lyxo-4-hexulose reductase that synthesizes dtdp-6-deoxy-l-talose. | kitasatospora kifunensis, the talosin producer, was used as a source for the dtdp-6-deoxy-l-talose (dtdp-6dtal) biosynthetic gene cluster, serving as a template for four recombinant proteins of rmla(kkf), rmlb(kkf), rmlc(kkf), and tal, which complete the biosynthesis of dtdp-6dtal from dttp, alpha-d-glucose-1-phosphate, and nad(p)h. the identity of dtdp-6dtal was validated using (1)h and (13)c nmr spectroscopy. k. kifunensistal and tll, the known dtdp-6dtal synthase gene of actinobacillus actino ... | 2010 | 20667525 |
| role of the atm-checkpoint kinase 2 pathway in cdt-mediated apoptosis of gingival epithelial cells. | the cytolethal distending toxin (cdt) of the oral pathogen aggregatibacter actinomycetemcomitans induces cell cycle arrest and apoptosis in various cell types. western analysis, pharmacological inhibition and sirna silencing were performed in human immortalized gingival keratinocytes (higk) to dissect the functional role of the ataxia telangiectasia mutated (atm) pathway in the signal transduction steps triggered by the cdt. infection of higk was associated with a time-dependent induction of cyt ... | 2010 | 20668524 |
| aggregatibacter actinomycetemcomitans-induced bone loss and antibody response in three rat strains. | the aim of this study is to compare the colonization, immunoglobulin (ig) g response, and alveolar bone loss in aggregatibacter actinomycetemcomitans (aa)-inoculated fawn hooded hypertensive (fhh), dahl salt-sensitive (dss), and brown norway (bn) rats. | 2011 | 20681810 |
| association between interleukin-6 -174 polymorphism and aggregatibacter actinomycetemcomitans in chronic periodontitis. | we previously demonstrated an association between interleukin-6 (il-6) polymorphisms and the detection of periodontopathogenic bacteria in aggressive and chronic periodontitis on a patient basis (pooled samples). the aim of this study is to comprehensively analyze the relative contribution of il-6 genetic factors and local (tooth and site) factors on the detection of aggregatibacter actinomycetemcomitans (previously actinobacillus actinomycetemcomitans) and porphyromonas gingivalis in patients w ... | 2010 | 20681812 |
| mapping the epithelial-cell-binding domain of the aggregatibacter actinomycetemcomitans autotransporter adhesin aae. | the gram-negative periodontopathogen aggregatibacter actinomycetemcomitans (aa) binds selectively to buccal epithelial cells (becs) of human and old world primates by means of the outer-membrane autotransporter protein aae. we speculated that the exposed n-terminal portion of the passenger domain of aae would mediate binding to becs. by using a series of plasmids that express full-length or truncated aae proteins in escherichia coli, we found that the bec-binding domain of aae was located in the ... | 2010 | 20688817 |
| prevalence of periodontal bacteria in saliva of kuwaiti children at different age groups. | aggregatibacter (formerly actinobacillus) actinomycetemcomitans, tannerella forsythensis and porphyromonas gingivalis and to a lesser extent prevotella intermedia and prevotella nigrescens, are gram-negative species that are associated with destructive periodontitis. studies from different parts of the world have shown variable detection rates of periodontal organisms. hardly any data exist on their carriage in children living in the middle east. this study was designed to determine the detectio ... | 2010 | 20701895 |
| aggregatibacter (actinobacillus) actinomycetemcomitans: a triple a* periodontopathogen? | 2010 | 20712635 | |
| differential epithelial cell response upon stimulation with the aggregatibacter actinomycetemcomitans strains vt 1169, vt 1560 dam⁻ and atcc 4318. | aggregatibacter actinomycetemcomitans is known to play a role in human inflammatory oral diseases. the present study aimed to test whether gecs from different individuals show an altered immune response when exposed to wild-type a. actinomycetemcomitans biofilms (vt 1169 and atcc43718) versus vt 1560 lacking a dna-adenine-methyltransferase (dam⁻). gecs were cultured from biopsies derived from three healthy subjects (a, b, and c). to obtain a. actinomycetemcomitans biofilms, each strain (vt 1169, ... | 2010 | 20716951 |
| analysis of immune responses to purified recombinant antigens of periodontal pathogens. | the accumulating knowledge about host-pathogen interactions in infectious diseases shows how the immune system interfaces with pathogens, and thus, helps us in understanding the pathogenesis of diseases and improving their treatment. purified antigens are indispensable while investigating the immune response in both innate and acquired immunities. it is ideal to use native antigens purified from the host organisms in native conditions that sustain their biological activity completely. however, p ... | 2010 | 20717794 |
| modulation of matrix metalloproteinase and cytokine production by licorice isolates licoricidin and licorisoflavan a: potential therapeutic approach for periodontitis. | inflammatory cytokines and matrix metalloproteinases (mmps) produced by resident and inflammatory cells in response to periodontopathogens play a major role in the tissue destruction observed in periodontitis, which is a disease that affects tooth-supporting structures. in the present study, we investigate the effects of licorice-derived licoricidin (lc) and licorisoflavan a (lia) on the secretion of various cytokines and mmps by human monocyte-derived macrophages stimulated with aggregatibacter ... | 2011 | 20722535 |
| recurrent infective endocarditis due to aggregatibacter actinomycetemcomitans: reinfection or relapse? | aggregatibacter actinomycetemcomitans is commonly part of the normal microflora of the human upper respiratory tract. it has been implicated in periodontal disease and various infections, particularly endocarditis. we report here what we believe to be the first case of recurrent infective endocarditis due to a. actinomycetemcomitans in a 44-year-old woman occurring 5 years after the initial episode. genomic analysis proved that the strains were closely related. despite efficient antibiotic treat ... | 2010 | 20724510 |
| markedly different genome arrangements between serotype a strains and serotypes b or c strains of aggregatibacter actinomycetemcomitans. | bacterial phenotype may be profoundly affected by the physical arrangement of their genes in the genome. the gram-negative species aggregatibacter actinomycetemcomitans is a major etiologic agent of human periodontitis. individual clonal types of a. actinomycetemcomitans may exhibit variable virulence and different patterns of disease association. this study examined the genome arrangement of a. actinomycetemcomitans using the genome sequences of serotypes a-c strains. the genome alignment and r ... | 2010 | 20825670 |
| a 6-month study of the effects of 0.3% triclosan/copolymer dentifrice on dental implants. | supportive therapy to maintain dental implants is increasingly important. this study examined the effect of a 0.3% triclosan/2% copolymer dentifrice on oral biofilms and gingival inflammation (gi) on dental implants and peri-implant tissues. | 2011 | 20831669 |
| efficacy and safety of adjunctive local moxifloxacin delivery in the treatment of periodontitis. | moxifloxacin exerts excellent antibacterial activity against most putative periodontal pathogens and has been shown to kill bacteria in biofilm and host cells. | 2011 | 20843236 |
| suppression of lps-induced matrix-metalloproteinase responses in macrophages exposed to phenytoin and its metabolite, 5-(p-hydroxyphenyl-), 5-phenylhydantoin. | abstract: | 2010 | 20843335 |
| determinants of periodontopathogens in microbiological monitoring of diabetic patients with periodontitis. | to determine and analyze the frequency of periodontopathogens in microbiological monitoring of diabetic patients with periodontitis. | 2010 | 20844819 |
| il6 -174 genotype associated with aggregatibacter actinomycetemcomitans in indians. | genetic factors have recently been associated with presence of aggregatibacter actinomycetemcomitans subgingivally in populations living in industrialized countries. the aim of this study was to analyse associations between interleukin-6 (il6) single nucleotide polymorphisms and presence and levels of a. actinomycetemcomitans and other subgingival microbes in a rural indian population. | 2011 | 20860759 |
| in vitro antimicrobial activity of brazilian medicinal plant extracts against pathogenic microorganisms of interest to dentistry. | this study evaluated the susceptibility of oral pathogenic microorganisms candida albicans, streptococcus mutans, staphylococcus aureus, and aggregatibacter actinomycetemcomitans to brazilian medicinal plant extracts of schinus terebinthifolius (aroeira), croton campestris (velame), lafoensia pacari (pacari), centaurium erythraea (centáurea), stryphnodendron adstringens (barbatimão), and anacardium humile (cajuzinho-docerrado), as compared to standardized antimicrobial agents (nystatin, chloramp ... | 2011 | 20862640 |
| investigation of subgingival profile of periodontopathic bacteria using polymerase chain reaction. | periodontopathic bacteria such as porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, tannerella forsythia, campylobacter rectus and treponema denticola play an important role in the initiation and progression of periodontitis. the aim of this investigation was to evaluate the relationship between periodontal clinical parameters and the subgingival profile of periodontopathic bacteria. twenty-six periodontitis patients (23-62 years of age; mean age, 40.2±13.2) with no systemic disea ... | 2010 | 20877160 |
| fimbriae-associated genes are biofilm-forming factors in aggregatibacter actinomycetemcomitans strains. | aggregatibactor actinomycetemcomitans colonizes human periodontal lesions and is implicated in both aggressive periodontitis and chronic periodontitis. clinical isolated colonies of a. actinomycetemcomitans were rough type. the rough type has a remarkable ability to adhere tenaciously to solid surfaces and colonize firmly. rough type colonies change into smooth type colonies during the course of repeated inoculation and biofilm-forming activity ceases. adherence by a. actinomycetemcomitans is me ... | 2010 | 20877161 |
| aggregatibacter actinomycetemcomitans as an early colonizer of oral tissues: epithelium as a reservoir? | this study examined in vivo and in vitro colonization by aggregatibacter actinomycetemcomitans, an organism highly associated with aggressive periodontitis. thirteen volunteers (5 were a. actinomycetemcomitans positive for buccal epithelial cells [becs] and teeth, 5 were a. actinomycetemcomitans positive for teeth only, and 3 were a. actinomycetemcomitans-negative controls) had two mandibular stents fabricated. each stent contained 3 removable hydroxyapatite (ha) tooth surrogates. one ha square ... | 2010 | 20881174 |
| characterization of a novel riboswitch-regulated lysine transporter in aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans is an opportunistic pathogen that resides primarily in the mammalian oral cavity. in this environment, a. actinomycetemcomitans faces numerous host- and microbe-derived stresses, including intense competition for nutrients and exposure to the host immune system. while it is clear that a. actinomycetemcomitans responds to precise cues that allow it to adapt and proliferate in the presence of these stresses, little is currently known about the regulatory mecha ... | 2010 | 20889741 |
| photolysis of hydrogen peroxide, an effective disinfection system via hydroxyl radical formation. | the relationship between the amount of hydroxyl radicals generated by photolysis of h(2)o(2) and bactericidal activity was examined. h(2)o(2) (1 m) was irradiated with laser light at a wavelength of 405 nm to generate hydroxyl radicals. electron spin resonance spin trapping analysis showed that the amount of hydroxyl radicals produced increased with the irradiation time. four species of pathogenic oral bacteria, staphylococcus aureus, aggregatibacter actinomycetemcomitans, streptococcus mutans, ... | 2010 | 20921319 |
| the use of ozonated water and 0.2% chlorhexidine in the treatment of periodontitis patients: a clinical and microbiologic study. | the development of periodontal disease has been thought to be associated with several restricted members of the oral anaerobic species, such as black-pigmented porphyromonas species and actinobacillus actinomycetemcomitans (aa), in the subgingival environment. apart from bacteria, certain viruses and fungi that are associated with periodontal disease are also present in the subgingival plaque . | 2010 | 20930341 |
| clarithromycin accumulation by phagocytes and its effect on killing of aggregatibacter actinomycetemcomitans. | clarithromycin inhibits several periodontal pathogens and is concentrated inside gingival fibroblasts and epithelial cells by an active transporter. we hypothesized that polymorphonuclear leukocytes (pmns) and less mature myeloid cells possess a similar transporter for clarithromycin. it is feasible that clarithromycin accumulation inside pmns could enhance their ability to kill aggregatibacter actinomycetemcomitans (previously actinobacillus actinomycetemcomitans). | 2010 | 20932153 |
| oxygen tension modulates the cytokine response of oral epithelium to periodontal bacteria. | there is an inverse relationship between pocket depth and pocket oxygen tension with deep pockets being associated with anaerobic bacteria. however, little is known about how the host tissues respond to bacteria under differing oxygen tensions within the periodontal pocket. | 2010 | 20955352 |
| setup of an in vitro test system for basic studies on biofilm behavior of mixed-species cultures with dental and periodontal pathogens. | caries and periodontitis are important human diseases associated with formation of multi-species biofilms. the involved bacteria are intensively studied to understand the molecular basis of the interactions in such biofilms. this study established a basic in vitro single and mixed-species culture model for oral bacteria combining three complimentary methods. the setup allows a rapid screening for effects in the mutual species interaction. furthermore, it is easy to handle, inexpensive, and repro ... | 2010 | 20957048 |
| active principles of grindelia robusta exert antiinflammatory properties in a macrophage model. | plant extracts and/or secondary metabolites are receiving considerable attention as therapeutic agents for treating inflammatory diseases such as periodontitis, which affects the tooth supporting tissues. the aim of this study was to investigate the effect of a grindelia robusta extract enriched in saponins and polyphenols on aggregatibacter actinomycetemcomitans lipopolysaccharide (lps)-induced inflammatory mediator (il-6, tnf-a, rantes, mcp-1, pge(2) ) and matrix metalloproteinase (mmp-1, -3, ... | 2010 | 21031629 |
| [acral pustules as the key manifestation in the diagnosis of subacute infective endocarditis]. | 2010 | 21034713 | |
| activity of antimicrobial peptide mimetics in the oral cavity: ii. activity against periopathogenic biofilms and anti-inflammatory activity. | whereas periodontal disease is ultimately of bacterial etiology, from multispecies biofilms of gram-negative anaerobic microorganisms, much of the deleterious effects are caused by the resultant epithelial inflammatory response. hence, development of a treatment that combines anti-biofilm antibiotic activity with anti-inflammatory activity would be of great utility. antimicrobial peptides (amps) such as defensins are naturally occurring peptides that exhibit broad-spectrum activity as well as a ... | 2010 | 21040516 |
| association of serum immunoglobulin g (igg) levels against two periodontal pathogens and prothrombotic state: a clinical pilot study. | abstract: | 2010 | 21050426 |
| development and in vitro evaluation of biopolymers as a delivery system against periodontopathogen microorganisms. | periodontal disease is the major cause of tooth loss in adults. porphyromonas gingivalis and aggregatibacter actinomycetemcomitans are considered key pathogens in periodontitis. the treatment consists of oral hygiene education, instrumentation for removal of calculus (scaling), chemotherapy and periodontal surgery. several agents are commercially available; these chemicals can alter oral microbiota and have undesirable side-effects such as vomiting, diarrhea and tooth staining. hence, the search ... | 2010 | 21053691 |
| early bacterial colonization and soft tissue health around zirconia and titanium abutments: an in vivo study in man. | aim: to compare the early bacterial colonization and soft tissue health of mucosa adjacent to zirconia (zro(2) ) and titanium (ti) abutment surfaces in vivo. materials and methods: twenty edentulous subjects received two endosseous mandibular implants. the implants were fitted with either a zro(2) or a ti abutment (non-submerged implant placement, within-subject comparison, left-right randomization). sulcular bacterial sampling and the assessment of probing pocket depth, recession and bleeding o ... | 2010 | 21054554 |
| c-reactive protein as a systemic marker of inflammation in periodontitis. | periodontitis has been identified as a potential risk factor for systemic pathologies such as cardiovascular disease (cvd). the aims of this investigation were to assess the relationship between periodontitis and systemic inflammatory factor, as well as to discover whether there is a relation to the severity of periodontitis and to the periodontopathogens. periodontal examinations and serum c-reactive protein (crp) level measurements were performed in 50 patients with periodontitis. periodontal ... | 2010 | 21057970 |
| systemic inflammatory responses in progressing periodontitis during pregnancy in a baboon model. | this study tested the hypothesis that pregnant female baboons exhibit increased levels of various inflammatory mediators in serum resulting from ligature-induced periodontitis, and that these profiles would relate to periodontal disease severity/extent in the animals. the animals were sampled at baseline (b), mid-pregnancy (mp; two quadrants ligated) and at delivery (d; four quadrants ligated). all baboons developed increased plaque, gingival inflammation and bleeding, pocket depths and attachme ... | 2010 | 21070210 |
| clinical case report on treatment of generalized aggressive periodontitis. | the purpose of this study was to evaluate the improvement of periodontal health of generalized aggressive periodontitis (gagp) diagnosed patients treated with non-surgical periodontal therapy accompanying systemic antibiotics administration. | 2010 | 21072223 |
| detection of the highly leucotoxic jp2 clone of aggregatibacter actinomycetemcomitans in members of a caucasian family living in sweden. | carriers of the jp2 clone of aggregatibacter actinomycetemcomitans exhibit an enhanced risk for developing aggressive periodontitis compared with individuals carrying non-jp2 clones. while the jp2 clone is almost exclusively detected among adolescents of african descent, reports on caucasians colonized with the jp2 clone are remarkably few. | 2010 | 21073494 |
| periodontal pathogen aggregatibacter actinomycetemcomitans lps induces mitochondria-dependent-apoptosis in human placental trophoblasts. | increasing evidence suggests an association between periodontal disease and low birthweight (lbw); however the underlying molecular mechanisms are yet to be fully elucidated. in this study, we performed a microarray analysis to observe the human placental trophoblast-like bewo cells response to lipopolysaccharide (lps) from periodontopathogen aggregatibacter actinomycetemcomitans (aa), in order to investigate the molecular basis of mechanisms for periodontitis-associated lbw. in vivo pregnant ra ... | 2010 | 21074850 |
| antibody to receptor activator of nf-κb ligand ameliorates t cell-mediated periodontal bone resorption. | activated t and b lymphocytes in periodontal disease lesions express receptor activator of nf-κb ligand (rankl), which induces osteoclastic bone resorption. the objective of this study was to evaluate the effects of anti-rankl antibody on periodontal bone resorption in vitro and in vivo. aggregatibacter actinomycetemcomitans outer membrane protein 29 (omp29) and a. actinomycetemcomitans lipopolysaccharide (lps) were injected into 3 palatal gingival sites, and omp29-specific t clone cells were tr ... | 2010 | 21078845 |
| the effect of a single episode of antimicrobial photodynamic therapy in the treatment of experimental periodontitis. microbiological profile and cytokine pattern in the dog mandible. | the purpose of this study was to evaluate the effect of a single application of antimicrobial photodynamic therapy (apdt) on microbiological profile and cytokine pattern in dogs. periodontal disease was induced by placing 3.0 silk ligatures around the mandibular pre-molars bilaterally during 8 weeks. the dogs were randomly treated with apdt using a dye/laser system, scaling and root planning (srp), or with the association of treatments (srp + apdt). plaque samples were collected at baseline, 1, ... | 2010 | 21086009 |
| one-stage full-mouth disinfection as a therapeutic approach for generalized aggressive periodontitis. | background: data concerning treatment outcomes in patients with generalized aggressive periodontitis (gagp) are limited. the aim of this study is to investigate 6-month clinical and microbiologic outcomes of the one-stage full-mouth disinfection (osfmd) in the management of patients with gagp. methods: twenty-seven patients with advanced gagp were included in this prospective follow-up intervention study. clinical and microbiologic parameters were collected at baseline and 3 and 6 months after t ... | 2010 | 21091345 |
| sensitivity of the periodontal pathogen aggregatibacter actinomycetemcomitans at mildly acidic ph. | background: aggregatibacter actinomycetemcomitans (previously actinobacillus actinomycetemcomitans), a capnophilic facultative anaerobe, is associated with localized aggressive periodontitis and endocarditis. when grown in broth, the cells begin to die rapidly after overnight growth. the cells also often lose viability on plates within a few days. the aim of this study is to identify the cause of the rapid loss of cell viability. methods: cell viabilities, as measured by colony forming units, we ... | 2010 | 21091350 |
| prevalence and distribution of aggregatibacter actinomycetemcomitans serotypes and the jp2 clone in a greek population. | to investigate the distribution of aggregatibacter actinomycetemcomitans serotypes and the prevalence of the jp2 clone in subgingival samples of greek subjects. | 2010 | 21092055 |
| periodontopathogens induce soluble p-selectin release by endothelial cells and platelets. | soluble p-selectin plays a pivotal role in inflammation and the development of thrombotic and cardiovascular disease. accordingly, elevated levels of soluble p-selectin are found in periodontitis and (other forms of) inflammatory diseases. however, the cellular source of soluble p-selectin in periodontitis and the effects of periodontopathogens on p-selectin release are unknown. | 2010 | 21106229 |
| association of three bacterial species and periodontal status in chinese adults: an epidemiological approach. | aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, and tannerella forsythia are oral pathogens associated with periodontitis. the association between these three bacteria and periodontal disease has been reported in populations of many countries. however, corresponding data in chinese populations are still lacking. the aim of this study was to detect these pathogens in subgingival plaque collected from 468 subjects with chronic periodontitis in a group of chinese adults by using a ... | 2010 | 21106792 |
| humoral immune response to aggregatibacter actinomycetemcomitans leukotoxin. | periodontal disease is an inflammatory condition caused by bacterial infections that result in loss of the tooth supporting tissue. the periodontal pathogens produce virulence factors with capacity to affect the host immune response. aggregatibacter actinomycetemcomitans is a periodontal pathogen that produces a leukotoxin that specifically affects human leukocytes. the aims of the present study were to examine the presence and function of systemic antibodies to the leukotoxin. | 2010 | 21118415 |
| [gene cloning of cdtb from actinobacillus actinomycetemcomitans and bioactivity test of the recombinant protein cdtb in vitro]. | to construct the prokayotic expression vector pet-15b-cdtb containing the cdtb gene from actinobacillus actinomycetemcomitans (aa) and to test the bioactivity of this recombinant cdtb in vitro. | 2010 | 21122366 |
| maintenance after a complex orthoperio treatment in a case of generalized aggressive periodontitis: 7-year result. | generalized aggressive periodontitis (gagp) encompasses a distinct type of periodontal disease exhibiting much more rapid periodontal tissue destruction than chronic periodontitis. the best method for management of gagp may include the use of both regenerative periodontal techniques and the administration of systemic antibiotics. | 2010 | 21128529 |
| bacterial and viral pathogens in saliva: disease relationship and infectious risk. | 2011 | 21134228 | |
| serum cytokine levels in periodontitis patients in relation to the bacterial load. | background: periodontitis is a local inflammatory disease that also has some systemic effects. we investigated the levels of interferon (ifn)-γ, tumor necrosis factor (tnf)-α, and interleukin (il)-2, -4, -5, and -10 in the serum of patients with periodontitis in relation to the bacterial load in the dental plaques. methods: serum cytokine levels in patients with generalized periodontitis and healthy control groups were determined using the cytometric bead array kit. bacterial load in the dental ... | 2010 | 21138356 |
| porphyromonas gingivalis promotes murine abdominal aortic aneurysms via matrix metalloproteinase-2 induction. | abdominal aortic aneurysm (aaa) is a common and lethal disorder, and mmps are highly expressed in aaa lesions. large numbers of periodontopathic bacteria have been reported to be present in specimens obtained from the aortic walls of patients with an aaa. the purpose of this study was to analyze the influence of periodontopathic bacteria on aaa dilatation. | 2010 | 21143481 |
| functional interferences in host inflammatory immune response by airway allergic inflammation restrain experimental periodontitis development in mice. | periodontal disease (pd) and airway allergic inflammation (al) present opposing inflammatory immunological features and clinically present an inverse correlation. however, the putative mechanisms underlying such opposite association are unknown. | 2010 | 21143491 |
| comparison of real-time polymerase chain reaction and dna-strip technology in microbiological evaluation of periodontitis treatment. | the impact of a semiquantitative commercially available test based on dna-strip technology (microident®, hain lifescience, nehren, germany) on diagnosis and treatment of severe chronic periodontitis of 25 periodontitis patients was evaluated in comparison with a quantitative in-house real-time pcr. subgingival plaque samples were collected at baseline as well as at 3, 6, and 12 months later. after extracting dna, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, tannerella forsyth ... | 2011 | 21146709 |
| antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits. | 4-hydroxycordoin (1), a natural isopentenyloxychalcone, is a plant secondary metabolite that is relatively rare. since there are very few reports about the biological activities of 1, its potential benefits for periodontal disease were investigated. a marked and dose-dependent antibacterial activity of 1 was observed against the three major periodontal pathogens, porphyromonas gingivalis, fusobacterium nucleatum, and prevotella intermedia. moreover, compound 1 showed an antiadhesion effect, sinc ... | 2010 | 21158427 |
| comparison of the use of the halimeter and the oral chroma™ in the assessment of the ability of common cultivable oral anaerobic bacteria to produce malodorous volatile sulfur compounds from cysteine and methionine. | to compare the use of the halimeter and the oral chroma™ to assess the ability of common oral anaerobic bacteria isolated from the kuwaiti population to produce volatile sulfur compounds (vscs). | 2010 | 21160219 |