Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| human papillomavirus-induced lesions on tattoos may show features of seborrheic keratosis. | 2011 | 21422356 | |
| [demyelinating disease and vaccination of the human papillomavirus]. | primary prevention by prophylactic vaccination against the major cause of cervical cancer, the carcinogenic human papillomavirus (hpv) types 16 and 18, is now available worldwide. postlicensure adverse neurological effects have been described. the studies realized after the license are descriptive and limited by the difficulty to obtain the information, despite most of the statistical indexes show that the adverse effects by the vaccine of the hpv are not upper compared with other vaccines, the ... | 2011 | 21425100 |
| in vivo longitudinal imaging of experimental human papillomavirus infection in mice with a multicolor fluorescence mini-endoscopy system. | human papillomavirus (hpv) infection is the most common sexually transmitted infection. vaccines for hpv infection can reduce the risk of developing cervical cancer. to further improve such vaccines and to explore other methods of preventing or treating viral infection, longitudinal studies in experimental animals are desirable. here, we describe a newly developed multicolor endoscopic fluorescence imaging system to visualize early hpv infection with fluorescent protein-encoded pseudoviruses (ps ... | 2011 | 21430072 |
| comparison of clinical and analytical performance of the abbott realtime high risk hpv test to the performance of hybrid capture 2 in population-based cervical cancer screening. | the clinical performance of the abbott realtime high risk hpv (human papillomavirus) test (realtime) and that of the hybrid capture 2 hpv dna test (hc2) were prospectively compared in the population-based cervical cancer screening setting. in women >30 years old (n = 3,129), the clinical sensitivity of realtime for detection of cervical intraepithelial neoplasia of grade 2 (cin2) or worse (38 cases) and its clinical specificity for lesions of less than cin2 (3,091 controls) were 100% and 93.3%, ... | 2011 | 21430098 |
| molecular methods for a correct diagnosis of multiple hpv infections and clinical implications for vaccine. | the human papillomavirus (hpv) family is characterized by minimal genotypic differences corresponding to different virus types. the aim of this study was to detect the hpv coinfections and the inner genotype in a series of 336 cervical-vaginal samples. | 2011 | 21430458 |
| high-risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer. | background: the purpose of this study was to determine the role of high-risk human papillomavirus (hpv) in lymph node metastasis and the depth of invasion in oropharyngeal cancer. methods: the study included patients with 90 oral carcinomas and 66 oropharyngeal carcinomas. high-risk hpv in situ hybridization was performed to detect hpv infection. results: the positive rate of high-risk hpv in situ hybridization was 15.4% (24 of 156). there was a significant difference in the fraction of positive ... | 2011 | 21438064 |
| nuclear translocation of +¦-catenin and decreased expression of epithelial cadherin in human papillomavirus-positive tonsillar cancer: an early event in human papillomavirus-related tumour progression? | high-risk human papillomaviruses (hpvs) constitute an important risk factor for tonsillar cancer. this study describes changes in cell adhesion molecules during metastasis of hpv-related and hpv-unrelated tonsillar carcinomas. | 2011 | 21438909 |
| a cyano analogue of boswellic acid induces crosstalk between p53/puma/bax and telomerase that stages the human papillomavirus type 18 positive hela cells to apoptotic death. | the p53 tumor suppressor pathway is disrupted by human papillomavirus (hpv) in over 90% of cervical cancers. hpv e6 protein promotes the degradation of p53 thereby inhibiting its stabilization and activation. this study demonstrates that treatment with a novel cyano derivative of 11-keto-ß-boswellic acid, i.e. butyl 2-cyano-3, 11-dioxours-1,12-dien-24-oate (bcdd) reduced the viral e6 mrna expression and lead to the accumulation of transcriptionally active p53 in the nucleus of hpv18 hela cells f ... | 2011 | 21440536 |
| circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect. | surges of serum abs after immunization and infection are highly specific for the offending ag, and recent studies demonstrate that vaccines induce transient increases in circulating ab-secreting cells (ascs). these ascs are highly enriched but not universally specific for the immunizing ag, suggesting that a fraction of these ascs could arise from polyclonal bystander stimulation of preexisting memory cells to unrelated ags. this model is proposed to explain maintenance of long-lived serological ... | 2011 | 21441455 |
| role and predictive strength of transglutaminase type 2 expression in premalignant lesions of the cervix. | the demonstration that type 2 transglutaminase (tg2) can incorporate polyamine into the e7 oncoprotein of human papillomavirus (hpv) type 18 has led to the hypothesis that tg2 can have a role in the host cellular response to hpv infection. the aim of this study was to investigate whether hpv-related pathology, in infected human cervical epithelium, was associated with modulation of tg2 expression. normal controls and hpv-infected cervical biopsies were analyzed for the expression of tg2, and the ... | 2011 | 21441900 |
| p16/ki-67 dual-stain cytology in the triage of ascus and lsil papanicolaou cytology: results from the european equivocal or mildly abnormal papanicolaou cytology study. | the objective of this study was to analyze the diagnostic performance of a newly established immunocytochemical dual-stain protocol, which simultaneously detects p16(ink4a) and ki-67 expression in cervical cytology samples, for identifying high-grade cervical intraepithelial neoplasia (cin2+) in women with papanicolaou (pap) cytology results categorized as atypical squamous cells of undetermined significance (ascus) or low-grade squamous intraepithelial lesions (lsil). | 2011 | 21442767 |
| human papillomavirus genotyping as a predictor of high-grade cervical dysplasia in women with mildly cytologic abnormalities: a two-year follow-up report. | high-risk human papillomavirus (hr-hpv) dna testing has emerged as another testing modality for women with mildly cytologic abnormalities. we conducted a two-year follow-up study of 108 women with mildly abnormal cervical cytology for detection of cin 2/3. a cervical swab sample was obtained for hpv genotyping by a hpv blot and histologic follow-up results were correlated with hr-hpv types. of the 108 cases, 93 (86.1%) were positive for hr-hpv dna. hpv-16 was detected in 45.1% of patients. cin g ... | 2011 | 21442773 |
| the role of human papillomavirus in the pathogenesis of head & neck squamous cell carcinoma: an overview. | cancer statistics report an increased incidence of oscc and opscc around the world. though improvements in screening and early diagnosis have dramatically reduced the incidence of this neoplasm in recent years, the 5-year-disease-free survival, is still poor, specially for oropharyngeal cancer, despite the great scientific and financial efforts. recently, several papers showed that hpv may be involved at least in the pathogenesis of a subgroup of oral and cervical scc, leading to distinct molecu ... | 2011 | 21447181 |
| laryngeal papilloma cells in culture have an altered cytoskeleton. | we have investigated the effect of human papillomavirus (hpv) transformation on cellular cytoarchitecture. cells from laryngeal papillomas and normal epithelium were cultured in vitro. cytoskeletal components of both types of cells were visualized by immunofluorescence, to determine whether there were any differences in the structure or distribution of the cytoskeleton. there was no significant change in microtubules. two major components of the cytoskeleton, the intermediate filaments and the m ... | 1987 | 21449663 |
| increases in human papillomavirus detection during early hiv infection among women in zimbabwe. | individuals who acquire human immunodeficiency virus (hiv) may experience an immediate disruption of genital tract immunity, altering the ability to mount a local and effective immune response. this study examined the impact of early hiv infection on new detection of human papillomavirus (hpv). | 2011 | 21451006 |
| cost-effectiveness of different human papillomavirus vaccines in singapore. | human papillomavirus (hpv) vaccines are widely available and there have been studies exploring their potential clinical impact and cost-effectiveness. however, few studies have compared the cost-effectiveness among the 2 main vaccines available - a bivalent vaccine against hpv 16/18, and a quadrivalent vaccine against 6/11/16/18. we explore the cost-effectiveness of these two hpv vaccines in tropical singapore. | 2011 | 21453537 |
| human papillomavirus 16 e2 stability and transcriptional activation is enhanced by e1 via a direct protein-protein interaction. | human papillomavirus 16 e1 and e2 interact with cellular factors to replicate the viral genome. e2 forms homodimers and binds to 12 bp palindromic sequences adjacent to the viral origin and recruits e1 to the origin. e1 forms a di-hexameric helicase complex that replicates the viral genome. this manuscript demonstrates that e1 stabilises the e2 protein, increasing the half life in both c33a and 293 t cells respectively. this stabilisation requires a direct protein--protein interaction. in additi ... | 2011 | 21458836 |
| virucidal activity of the dendrimer microbicide spl7013 against hiv-1. | topical microbicides for use by women to prevent the transmission of human immunodeficiency virus (hiv) and other sexually transmitted infections are urgently required. dendrimers are highly branched nanoparticles being developed as microbicides. spl7013 is a dendrimer with broad-spectrum activity against hiv type i (hiv-1) and -2 (hiv-2), herpes simplex viruses type-1 (hsv-1) and -2 (hsv-2) and human papillomavirus. spl7013 [3% (w/w)] has been formulated in a mucoadhesive carbopol gel (vivagel® ... | 2011 | 21459115 |
| disconnects between news framing and parental discourse concerning the state-mandated hpv vaccine: implications for dialogic health communication and health literacy. | in 2007, virginia became the first state in the us to mandate the human papillomavirus (hpv) vaccine. in 2009, the mandate required that parents of girls entering sixth grade (ages 11-12) vaccinate their daughters or sign the 'opt-out' waiver. this investigation is the first to explore how both the news media and parents framed and responded to the newly-mandated hpv vaccine. this research reveals disjoints between news media framing and parental framing. implications of these gaps for parental ... | 2010 | 21462859 |
| human papillomavirus vaccine: widening the scope for cancer prevention. | human papillomavirus (hpv) is the necessary cause of cervical cancer. the hpv oncoproteins e6 and e7 have crucial roles in various steps of carcinogenesis, inducing degradation of p53 and destabilization of prb. several clinical trials show that recombinant hpv vaccines are safe and effective in preventing persistent infection of hpv and associated anogenital lesions. although most clinical studies to date have investigated the effectiveness of hpv vaccines in young female subjects, elderly fema ... | 2011 | 21465574 |
| targeted cellular uptake and sirna silencing by quantum-dot nanoparticles coated with ß-cyclodextrin coupled to amino acids. | quantum dots (qds) have the potential to serve as photostable beacons to track sirna delivery, which is fast becoming an attractive approach to probe gene function in cells. in this paper, we synthesized qd nanoparticles coated with ß-cyclodextrin (ß-cd) coupled to amino acids with different surface charges (positive, negative, and neutral) through direct ligand-exchange reactions and used them to deliver sirna. we found that these qds are diffluent in biological buffer with high colloidal stabi ... | 2011 | 21465588 |
| large loop excision of transformation zone procedures used in the management of cytological abnormalities of the cervix. | national health and medical research council (nhmrc) guidelines published in 2005 changed the management of cervical squamous intraepithelial lesions. asymptomatic low-grade abnormalities may be treated conservatively as many regress spontaneously. cervical changes reflect infection with the human papilloma virus (hpv). risk factors for acquiring hpv are the same as those for other sexually transmitted infections (stis). | 2011 | 21466510 |
| prediction of residual/recurrent disease by hpv genotype after loop excision procedure for high-grade cervical intraepithelial neoplasia with negative margins. | this study aims to evaluate whether the preconisation of high-risk human papillomavirus (hr-hpv) genotype and multiple hpv infection is predictive for residual/recurrent disease during the follow-up of high-grade cervical intraepithelial neoplasia (cin) treated by loop electrosurgical excision procedure (leep) with negative margins. | 2011 | 21466511 |
| il-10 expression is regulated by hpv e2 protein in cervical cancer cells. | it has been found that certain cytokines (il-4, il-10 and tgf-β1) are highly expressed locally in biopsies from patients with premalignant lesions and cervical cancer, and may induce a local immune-suppression state. in particular, il-10 is highly expressed in tumor cells and its expression is directly proportional to the development of hpv-positive cervical cancer, suggesting an important role of hpv proteins in the expression of il-10. in fact, we demonstrated that e6 and e7 hpv proteins regul ... | 2011 | 21468579 |
| assessment of clinical and analytical performance characteristics of an hpv genotyping test. | human papillomavirus (hpv), the known cause of cervical cancer, is found in essentially all cervical cancer specimens. infection with high-risk hpv genotypes carries the greatest risk of viral persistence and the potential to develop precancerous lesions or cervical cancer. identifying women infected with hpv 16 and/or 18, the two genotypes most commonly found in cervical cancer, helps further stratify women for either immediate referral to colposcopy or repeat cytological and hpv dna testing in ... | 2011 | 21472869 |
| human papilloma virus associated head and neck cancer: a pcr based study. | head and neck cancers (hnc), 90% of which are squamous cell carcinomas (scc), rank sixth among all malignancies worldwide and comprise 40-50% of the total number of malignancies in india. in addition to alcohol and tobacco usage, which is the major source of oral carcinogens, viruses such as human papilloma virus (hpv) may also contribute to development of the malignancy. the aim of this study was to identify the prevalence of hpv in head and neck cancers using material from metastatic site. a t ... | 2011 | 21472871 |
| human papilloma virus screening by hybrid capture ii in chinese women of jiangsu province. | to survey human papilloma virus (hpv) infection in chinese women of jiangsu province and discuss the relationship between hpv and the biology of cervical cancer. | 2010 | 21473391 |
| chlamydia trachomatis infection causes mitotic spindle pole defects independently from its effects on centrosome amplification. | chlamydiae are gram negative, obligate intracellular bacteria, and chlamydia trachomatis is the etiologic agent of the most commonly reported sexually transmitted disease in the united states. chlamydiae undergo a biphasic life cycle that takes place inside a parasitophorous vacuole termed an inclusion. chlamydial infections have been epidemiologically linked to cervical cancer in patients previously infected by human papillomavirus (hpv). the inclusion associates very closely with host cell cen ... | 2011 | 21477082 |
| what constitutes consent when parents and daughters have different views about having the hpv vaccine: qualitative interviews with stakeholders. | objective the uk human papillomavirus (hpv) vaccine programme commenced in the autumn of 2008 for year 8 (age 12-13 years) schoolgirls. we examine whether the vaccine should be given when there is a difference of opinion between daughters and parents or guardians. design qualitative study using semi-structured interviews. participants a sample of 25 stakeholders: 14 professionals involved in the development of the hpv vaccination programme and 11 professionals involved in its implementati ... | 2011 | 21478419 |
| methylation status of the long control region of hpv 16 in clinical cervical specimens. | dna methylation is one of the regulatory pathways that modulate human papillomavirus (hpv) gene expression. to obtain detailed methylation information on crucial areas of the long control region (lcr) of hpv 16 and to clarify the significance of methylation in clinical cervical lesions, 80 clinical samples were examined to determine the methylation status of the hpv 16 promoter and enhancer core using bisulfite modification and pyrosequencing. seventy samples [26 of cervical carcinoma (cc), 13 o ... | 2008 | 21479449 |
| altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma. | abstract conclusions: altered expression of claudin-1, claudin-7, and tricellulin in early tonsillar squamous cell carcinoma (scc) independent of human papilloma virus (hpv) infection may lead to tumor progression. objectives: integral tight junction proteins, the claudins and tricellulin, play a crucial role in all tissues. hpv is significantly associated with tonsillar scc. we sought to determine the expression of claudin-1, claudin-7, and tricellulin in hpv-infected and hpv-free tonsillar scc ... | 2011 | 21480761 |
| cost-effectiveness of human papillomavirus vaccination and cervical cancer screening in thailand. | please cite this paper as: sharma m, ortendahl j, van der ham e, sy s, kim j. cost-effectiveness of human papillomavirus vaccination and cervical cancer screening in thailand. bjog 2011; 10.1111/j.1471-0528.2011.02974.x. objective to assess the health and economic outcomes of various screening and vaccination strategies for cervical cancer prevention. design cost-effectiveness analysis from a societal perspective. setting thailand. population females aged 9 years and older. methods using a ... | 2011 | 21481160 |
| hpv vaccine acceptability in ghana, west africa. | cervical cancer is a leading cause of cancer-related mortality among women in ghana. as of this writing no data are available concerning knowledge, attitudes and acceptability of human papillomavirus (hpv) vaccination by women in ghana. | 2011 | 21481327 |
| design and characterization of an enhanced repressor of human papillomavirus e2 protein. | papillomaviruses are causative agents of cervical and anogenital cancers. the viral e2 protein mediates viral dna replication and transactivation of viral oncogenes and thus represents a specific target for therapeutic intervention. short forms of e2, e2r, contain only the c-terminal dimerization domain, and repress the normal function of e2 due to formation of an inactive heterodimer. using structure-guided design, we replaced conserved residues at the dimer interface to design a heterodimer wi ... | 2011 | 21482558 |
| advancing human papillomavirus research with a rhesus monkey model. | 2011 | 21483022 | |
| immunogenicity and reactogenicity of alternative schedules of hpv vaccine in vietnam: a cluster randomized noninferiority trial. | human papillomavirus (hpv) vaccine programs may decrease the morbidity and mortality due to cervical cancer seen among women in low-resource countries. however, the 3-dose schedule over a 6-month period is a potential barrier to vaccine introduction in such settings. | 2011 | 21486975 |
| smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study. | background:to prove a causal link between an epigenetic change and an environmental or behavioural risk factor for a given disease, it is first necessary to show that the onset of exposure precedes the first detection of that epigenetic change in subjects who are still free of disease.methods:towards this end, a cohort of women aged 15-19 years, recruited soon after they first had sexual intercourse, were used to provide sequential observations on the relationship between cigarette smoking and t ... | 2011 | 21487403 |
| [current events in vaccination.] | the annual meeting of the infectious disease society of america (idsa); which brought together nearly 5000 participants from over 80 countries in vancouver, canada, october 21 to 24, 2010; provided a review of the influenza (h1n1) 2009 pandemic, evaluated vaccination programmes and presented new vaccines under development. with 12 500 deaths in the united states in 2009-2010, the influenza (h1n1) 2009 pandemic was actually less deadly than the seasonal flu. but it essentially hit the young, and ... | 2011 | 21489733 |
| transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma. | β-human papillomavirus (β-hpv) dna is present in some cutaneous squamous cell carcinomas (cusccs), but no mechanism of carcinogenesis has been determined. we used ultra-high-throughput sequencing of the cancer transcriptome to assess whether papillomavirus transcripts are present in these cancers. in all, 67 cuscc samples were assayed for β-hpv dna by pcr, and viral loads were measured with type-specific quantitative pcr. a total of 31 sccs were selected for whole transcriptome sequencing. trans ... | 2011 | 21490616 |
| medical interventions for high grade vulval intraepithelial neoplasia. | vulval intraepithelial neoplasia (vin) is a pre-malignant condition of the vulval skin; its incidence is increasing in women under 50 years. vin is graded histologically as low grade or high grade. high grade vin is associated with infection with human papilloma virus (hpv) infection and may progress to invasive disease. there is no consensus on the optimal management of high grade vin. the high morbidity and high relapse rate associated with surgical interventions call for a formal appraisal of ... | 2011 | 21491403 |
| impact of an hpv6/11/16/18 l1 virus-like particle vaccine on progression to cervical intraepithelial neoplasia in seropositive women with hpv16/18 infection. | the impact of a human papillomavirus (hpv) vaccine on development of cervical intraepithelial neoplasia grade 2-3 or adenocarcinoma in situ (cin2-3/ais) in women with ongoing hpv16 or 18 infections prevaccination is reported. seventeen thousand six-hundred and twenty-two women aged 16-26 were enrolled in 1 of 2 randomized, placebo-controlled, efficacy trials (protocols 013 and 015). vaccine or placebo was given at day 1, month 2 and 6. women were tested for hpv6/11/16/18 dna and antibodies at da ... | 2011 | 21491420 |
| the combined influence of oral contraceptives and human papillomavirus virus on cutaneous squamous cell carcinoma. | the vast majority of cutaneous squamous cell carcinoma (cscc) will occur in those with fair complexion, tendency to burn, and high ultraviolet radiation (uvr) exposure. organ transplant recipients also are an important population at great risk for cscc. an association has been reported between oral contraceptive (oc) use, human papillomavirus virus (hpv) and cervical cancer, and there could be a similar association for cscc. the cutaneous hpv β-e6 protein, a close cousin of the transformative e6 ... | 2011 | 21499554 |
| single-chain fv fragment antibodies selected from an intrabody library as effective mono- or bivalent reagents for in vitro protein detection. | in spite of their many potential applications, recombinant antibody molecules selected by phage display are rarely available commercially, one reason being the absence of robust bacterial expression systems that yield sufficient quantities of reagents for routine applications. we previously described the construction and validation of an intrabody library that allows the selection of single-chain fv (scfv) fragments solubly expressed in the cytoplasm. here, we show that it is possible to obtain ... | 2011 | 21501618 |
| detection of human papillomavirus using hybrid capture 2 in oral brushings from patients with oropharyngeal squamous cell carcinoma. | detection of high-risk (hr) human papillomavirus (hpv) in oropharyngeal squamous cell carcinoma (scc) has important prognostic implications; patients exhibit improved survival compared with patients with hpv- scc. oral brushing and rinsing samples were obtained from patients with oropharyngeal, oral cavity, or hypopharyngeal scc and tested for hr-hpv using hybrid capture 2 (hc2; qiagen, valencia, ca). hr-hpv in situ hybridization (ish) was performed on biopsy tissue samples from the same patient ... | 2011 | 21502432 |
| a population-based clinical trial comparing endocervical high-risk hpv testing using hybrid capture 2 and cervista from the shenccast ii study. | our objective was to directly compare the accuracy of the high-risk human papillomavirus (hpv) assays, hybrid capture 2 (hc2; qiagen, gaithersburg, md) and cervista (hologic, bedford, ma), in diagnosing cervical intraepithelial neoplasia (cin) 3 or worse (cancer). a population-based, cross-sectional study (the shenzhen cervical cancer screening trial ii) was conducted in guangdong province in china. three high-risk hpv assays, self and direct cervical sampling and cytology, were studied. abnorma ... | 2011 | 21502436 |
| phase 1 randomized trial of the vaginal safety and acceptability of spl7013 gel (vivagel) in sexually active young women (mtn-004). | objectives:: the study was designed to assess the safety, adherence, acceptability, and effect on vaginal microflora of 3% spl7013 gel (vivagel), a novel dendrimer topical microbicide that inhibits hiv, herpes simplex virus-2, and human papillomavirus in vitro and in animal models. design:: phase 1, randomized, double-blind, placebo-controlled study on sexually active women. methods:: sixty-one sexually active women aged 18-24 years were recruited from three sites in the united states. participa ... | 2011 | 21505316 |
| hpv e6 proteins target ubc9, the sumo conjugating enzyme. | the human papillomavirus oncogenic protein, e6, interacts with a number of cellular proteins, and for some targets, e6 directs their degradation through the ubiquitin-proteasome pathway. post-translational modification with ubiquitin-like modifiers, such as sumo, also influences protein activities, protein-protein interactions, and protein stability. we report that the high risk hpve6 proteins reduce the intracellular quantity of the sole sumo conjugation enzyme, ubc9, concomitant with decreased ... | 2011 | 21510985 |
| human papilloma virus genotype diversity of anal infection among trans (male to female transvestites, transsexuals or transgender) sex workers in argentina. | reports on the prevalence and genotypes of hpv among trans (male to female transvestites, transsexuals or transgender) sex workers (tsw) are scarce in the literature. | 2011 | 21511521 |
| multiplexed detection of nucleic acids in a combinatorial screening chip. | multiplexed diagnostic testing has the potential to dramatically improve the quality of healthcare. simultaneous measurement of health indicators and/or disease markers reduces turnaround time and analysis cost and speeds up the decision making process for diagnosis and treatment. at present, however, most diagnostic tests only provide information on a single indicator or marker. development of efficient diagnostic tests capable of parallel screening of infectious disease markers could significa ... | 2011 | 21512691 |
| "i thought cancer was one of those random things. i didn't know cancer could be caught…": adolescent girls' understandings and experiences of the hpv programme in the uk. | the uk human papillomavirus (hpv) vaccination programme aims to provide girls aged 12-13 with protection against two of the most carcinogenic strains (types 16 and 18) of this sexually transmitted virus which together account for 70% of cases of cervical cancer. despite evidence suggesting a general lack of knowledge about hpv and its link with cervical cancer, vaccine uptake rates were generally high in the uk for the first year of the hpv vaccination programme. in countries that implemented th ... | 2011 | 21514348 |
| anogenital warts in danish men who have sex with men. | to determine the prevalence of anogenital warts (agws) and concurrent sexually transmitted infections (stis) in men who have sex with men (msm), and their knowledge of human papillomavirus (hpv). attitudes towards the hpv vaccine among msm are explored. a web-based cross-sectional survey on agws, sociodemographic factors and sexual behaviour conducted in august 2009 in denmark. overall 25.2% of the 1184 respondents reported a prior or current episode of agws. the prevalence of agw was significan ... | 2011 | 21515754 |
| reducing the rate of cervical cancer: ethical challenges in public health. | human papilloma virus (hpv) is the most common sexually transmitted infection in the united states and hpv is the single most significant risk factor for acquiring cervical cancer. there are two vaccines that prevent some strains of hpv and are believed to help reduce the rate of cervical cancer: whether or not the hpv vaccine should be mandated has resulted in monumental debates and given rise to several ethical concerns. for instance, how will mandating this vaccine affect the patient's right ... | 2010 | 21516924 |
| targeting hepatitis b virus and human papillomavirus induced carcinogenesis: novel patented therapeutics. | viral infections leading to carcinogenesis tops the risk factors list for the development of human cancer. the decades of research has provided ample scientific evidence that directly links 10-15% of the worldwide incidence of human cancers to the infections with seven human viruses. moreover, the insights gained into the molecular pathogenetic and immune mechanisms of hepatitis b virus (hbv) and human papillomavirus (hpv) viral transmission to tumour progression, and the identification of their ... | 2011 | 21517743 |
| human papillomavirus (hpv) prevalence and accuracy of hpv testing to detect high-grade cervical intraepithelial neoplasia. | concern was raised on using testing for high-risk (hr) human papillomavirus (hpv) in cervical cancer screening in populations where hpv prevalence is high. the impact of hr hpv prevalence on the efficiency of hpv test-based screening has never been directly evaluated. a meta-regression of the relationship between hr hpv prevalence and the specificity and positive predictive value (ppv) of hpv dna testing for the presence of cervical intraepithelial neoplasia grade 2 or worse (cin2+) was performe ... | 2011 | 21520039 |
| [whim syndrome: on the track of an interplay between human papillomavirus and the cxcl12 chemokine]. | 2011 | 21524391 | |
| shedding of epstein-barr virus and cytomegalovirus from the genital tract of women in a peri-urban community in andhra pradesh, india. | we found a large number of false-positive via (visual inspection with acetic acid) readings in a study of cervical cancer screening strategies (via, hpv dna testing, and pap cytology) in a peri-urban community in andhra pradesh, india. we evaluated whether these false-positives might be occurring as a result of infections with epstein-barr virus (ebv) or cytomegalovirus (cmv), prevalent latent herpesviruses known to be shed from the female genital tract. while we found that there was no associat ... | 2011 | 21525227 |
| risks for persistence and progression by human papillomavirus type 16 variant lineages among a population-based sample of danish women. | background: little is known about factors determining hpv16 persistence and progression, but several studies have suggested that genetic variants may play a role. methods: hpv16-positive women with normal cytology in a large danish cohort were re-assessed for hpv16 status at 2 years, and followed-up for cervical intraepithelial neoplasia 3 or worse (cin3+) over 11 years through linkage with a national pathology database. relative risks for clearance, persistence and progression were compared by ... | 2011 | 21527576 |
| a fast and simple in situ pcr method to detect human papilloma virus infection in archival paraffin-embedded tissues. | we describe a simple and fast method for the detection and localization of low copy numbers of hpv dna in formalin-fixed and paraffin-embedded archival tissues. we have developed a protocol for direct bl situ-pcr in order to demonstrate its convenience in rapid and reproducible assessment of hpv infection in unknown biopsies. the morphological aspect of the tissues has been maintained, despite the multiple steps of fixation, permeabilization and thermal cycling, and positivity has been detected ... | 1997 | 21528242 |
| the prevalence of human papillomavirus in oral premalignant lesions and squamous cell carcinoma in comparison to cervical lesions used as a positive control. | background: previous reports concerning the prevalence of human papillomavirus (hpv) in oral squamous cell carcinoma (oscc) have observed varied results. the aim of this study was to evaluate the prevalence of hpv in oral premalignant lesions (opl) and oscc. for accurate hpv detection in oral lesions, comparative analysis was performed on cervical lesions as positive controls. methods: fifty-seven cases with opl and 50 with oscc were selected. twenty-nine control cases were selected from cervica ... | 2011 | 21528380 |
| nucleotide deficiency promotes genomic instability in early stages of cancer development. | chromosomal instability in early cancer stages is caused by stress on dna replication. the molecular basis for replication perturbation in this context is currently unknown. we studied the replication dynamics in cells in which a regulator of s phase entry and cell proliferation, the rb-e2f pathway, is aberrantly activated. aberrant activation of this pathway by hpv-16 e6/e7 or cyclin e oncogenes significantly decreased the cellular nucleotide levels in the newly transformed cells. exogenously s ... | 2011 | 21529715 |
| regulation of nucleocytoplasmic trafficking of viral proteins: an integral role in pathogenesis? | signal-dependent targeting of proteins into and out of the nucleus is mediated by members of the importin (imp) family of transport receptors, which recognise targeting signals within a cargo protein and mediate passage through the nuclear envelope-embedded nuclear pore complexes. regulation of this process is paramount to processes such as cell division and differentiation, but is also critically important for viral replication and pathogenesis; phosphorylation appears to play a major role in r ... | 2011 | 21530593 |
| the potential role of self-sampling for high-risk human papillomavirus detection in cervical cancer screening. | high-risk human papillomavirus (hr-hpv) detection will become an important tool in the screening for cervical cancer. self-sampling is an inexpensive and well-accepted method for hpv detection that will increase participation of nonresponders in current screening programs. even more, because self-collected samples are as good as physician-collected samples for hpv detection, self-sampling might be a suitable method for future primary cervical cancer screening. copyright © 2011 john wiley & sons, ... | 2011 | 21538664 |
| viruses and the fuel sensor: the emerging link between ampk and virus replication. | adenosine 5' monophosphate-activated protein kinase (ampk) is conserved in all eukaryotic cells and functions as the key regulator of cellular metabolism by responding to the energy status of the cell. it is activated by an increase in the amp:atp ratio and then attempts to redress the balance by upregulating catabolic processes, whilst concomitantly inhibiting anabolic processes. despite its critical importance in the functioning of eukaryotic cells, there has been a paucity of studies investig ... | 2011 | 21538667 |
| completion and timing of the three-dose human papillomavirus vaccine series among adolescents attending school-based health centers in oregon. | many adolescents do not complete the 3-dose human papillomavirus vaccine series in the recommended time frame, or at all. given the challenges of administering a multi-dose vaccine to adolescents, especially those in vulnerable populations, we evaluated completion of the human papillomavirus vaccine series in 19 of oregon's school-based health centers. | 2011 | 21539853 |
| long-term impact of human papillomavirus vaccination on infection rates, cervical abnormalities, and cancer incidence. | : vaccination against human papillomavirus (hpv) types 16/18 is being implemented in many countries. there may be indirect benefit of hpv vaccination to nonvaccinated women, who may experience a reduced risk of infection with vaccine-preventable types (herd immunity). we attempt to disentangle the direct and indirect effects of hpv vaccination, while accounting for 14 oncogenic hpv types in a dynamic modeling framework. | 2011 | 21540743 |
| polymorphisms of mdm4 and risk of squamous cell carcinoma of the head and neck. | purpose: mouse double minute 4 (mdm4), a homolog of mdm2, is one of the key negative regulators of p53, and its amplification or overexpression contributes to carcinogenesis by inhibiting the p53 tumor suppressor activity. we investigated the association between mdm4 polymorphisms and the risk of squamous cell carcinoma of the head and neck (scchn). methods: we genotyped three mdm4 tagging polymorphisms, two in the 3' untranslated region (rs11801299g>a and rs10900598g>t) and one in intron 1 (rs1 ... | 2011 | 21540763 |
| nrip, a novel calmodulin binding protein, activates calcineurin to dephosphorylate hpv e2 protein. | previously, we found a gene named nuclear receptor interaction protein (nrip) (or dcaf6 or iqwd1). we demonstrate that nrip is a novel binding protein for human papillomavirus 16 (hpv-16) e2 protein. hpv-16 e2 and nrip can directly associate into a complex in vivo and in vitro, and the n-terminal domain of nrip interacts with the transactivation domain of hpv-16 e2. only full-length nrip can stabilize e2 protein and induce hpv gene expression, and nrip silenced by two designed sirnas decreases e ... | 2011 | 21543494 |
| additive inhibitory effects of retinoids and interferon-alpha on the growth of human cervical carcinoma cells. | the combination of 13-cis retinoic acid (13cra) and interferon-alpha (ifn-alpha) has shown marked antitumor activity against locally advanced cervical cancer in vivo. to begin to explore the mechanism and potential of the efficacy of this combination, the sensitivity of 9 cervical carcinoma cell lines to the growth inhibitory effects of these agents was examined after 1 to 7 days of treatment. ifn-alpha (100 u/ml) alone exerted variable effects. siha cell line was very sensitive showing 75% inhi ... | 1996 | 21544324 |
| characterisation of cellular changes which influence progression of human papillomavirus type-16 immortalised keratinocytes to anchorage-independent phenotype. | cellular alterations which influence progression to an anchorage-independent phenotype are poorly understood. few immortalised keratinocyte lines have been reported to form colonies in semi-solid medium, and the important role of the anchorage-dependence in controlling the behaviour of keratinocytes reflects the resistance of these cells to form colonies in soft agar. we describe here a model for studying in vitro the progression of human papillomavirus type-16 (hpv-16) immortalised keratinocyte ... | 1996 | 21544345 |
| p53 levels in human mammary epithelial cells expressing wild-type and mutant human papillomavirus type 16 (hpv-16) e6 proteins. | human fibroblast cells must overcome both the m1 and the m2 stages of cellular senescence to immortalize, at which point cells almost always express telomerase activity. the human papillomavirus (hpv) oncoproteins, hpv-16 e6 and e7, can block the progression to senescence in fibroblasts by associations with p53 and prb, respectively. human mammary epithelial (hme) cells require only hpv-16 e6 to bypass m1, suggesting that prb may not have a direct role in hme cells senescence. in the present rep ... | 1996 | 21544354 |
| detection of human papilloma virus (hpv) and k-ras mutations in human lung carcinomas. | the purpose of our study was to assess the prevalence and prognostic significance of hpv infection as well as k-ras codon 12 point mutations in lung cancer. patients diagnosed with lung carcinoma between 1988 and 1992 (n=99) were selected. hpv detection and typing was performed by pcr from paraffin-embedded tissues, while mutations in codon 12 of k-ras gene were detected using the restriction fragment length polymorphism (rflp) analysis. the prevalence of hpv infection was 15%, while k-ras codon ... | 1996 | 21544468 |
| [prevalence of high- and low-risk oncogenic human papillomaviruses in patients with external genital pathology]. | the paper presents the results of examining 49 patients with genital papillomas, vulvar and vaginal leukoplakia, dysplasia, and cancer. the findings may suggest that human papillomavirus plays an important role in the development of vulvar and vaginal lesions and reconsider the importance of high- and low-risk oncogenic genotypes in the development of benign neoplasms, precancerous conditions, and malignant tumors of the vulva and vagina. | 2011 | 21545037 |
| cervical human papilloma virus infection among the general female population in vietnam: a situation analysis. | human papilloma virus (hpv) is the necessary cause of cervical cancer. this survey used a sample of 1,500 married women aged 15-69 to examine the prevalence of hpv infection and hpv specific types in vietnam as well as risk factors of hpv infection. results indicated that the prevalence of hpv infection in hanoi and hcm was 6.13 and 8.27. the proportion of multiple hpv infection was also higher in hcm than in hanoi (35.5% vs. 17.4%). risk factors having significant associations with general hpv ... | 2011 | 21545230 |
| reported adverse events in girls aged 13-16 years after vaccination with the human papillomavirus (hpv)-16/18 vaccine in the netherlands. | in 2009, human papillomavirus (hpv) vaccination was offered to girls born in 1993-1996 in a catch-up campaign, followed in 2010 by the implementation of the vaccination in the national immunization programme (nip) for girls born in 1997. to monitor the tolerability of the 2009 catch-up campaign, we investigated the occurrence of adverse events within 7 days after vaccination with the bivalent hpv vaccine. a total of 6000 girls were asked to participate, including 1500 from each birth cohort from ... | 2011 | 21549785 |
| working to close the gap: identifying predictors of hpv vaccine uptake among young african american women. | abstract:factors associated with greater likelihood of human papillomavirus (hpv) vaccination among women who experience excess cervical cancer incidence and mortality requires further study. the purpose of this study was to assess factors associated with hpv vaccine uptake among young african american women. three hundred sixty-three african american women aged 18-26 were recruited from historically black colleges/universities to complete a questionnaire to assess health beliefs associated with ... | 2011 | 21551933 |
| considerations on the clinical application of the human papillomavirus vaccine in spain. | the circumstances that in the opinion of the authors influence the lower than expected uptake of the vaccine against human papillomavirus in spain are analyzed. among others, aspects related to doubts about efficacy and safety, the attitude of the spanish health authorities or the role of media and the antivaccine groups, as well as the vaccination "culture" of the gynecologist, are discussed. the authors conclude that only with the coordinated effort of all involved bodies in the vaccination pr ... | 2011 | 21552002 |
| polymorphism of the hpv-16 e6 gene of cervical-carcinoma. | polymorphism of the human papillomavirus type 16 (hpv-16) genome has been reported to occur within the noncoding regulatory long control region (lcr) and in the e7 and l1 genes. the current study focuses on the hpv-16 e6 oncogene which interacts with the antioncogenic regulator p53. seventy-eight hpv-16-positive dna samples derived from cervical carcinomas were screened for the presence of polymorphism in the hpv-16 e6 gene by polymerase chain reaction (pcr) linked single stranded conformational ... | 1995 | 21552834 |
| the gene encoding the p53-regulated inhibitor of cdks (pic1) is not expressed in the molt-4 leukemia-cell line with p53 truncated at the carboxyl-terminus, and harbors a nucleotide substitution at codon-31 in several other cancer cell-lines. | entry into the cell cycle is governed by cyclins, cyclin-dependent kinases (cdks) and cdk-inhibitors (cdkis). the p53-regulated inhibitor of cdks (pic1) is a universal cdki whose gene expression is directly induced by the p53 tumor suppressor protein. reverse transcription and polymerase chain reaction revealed strong pic1 gene expression in control mrc-5 human embryo lung cells, but relatively weaker bands in a549 lung carcinoma; hep3b, mahlavu, plc/prf/5 hepatocellular carcinoma; siha, caski, ... | 1995 | 21556614 |
| the relationship of knowledge, health value and health self-efficacy with men's intentions to receive the human papillomavirus (hpv) vaccine. | the aim of the present study was to determine whether it was possible to predict human papillomavirus (hpv) vaccination intentions an australian male sample. one hundred and twenty one males aged 18 to 26 (m = 22.3, sd = 2.06), completed an online survey assessing hpv-related knowledge, health beliefs and health self-efficacy. hpv knowledge and health self-efficacy were significant independent predictors of vaccine acceptance. a moderating effect was found between hpv knowledge and health self-e ... | 2011 | 21558104 |
| prevalence and risk factors of human papillomavirus (hpv) infection in southern chinese women - a population-based study. | persistent high-risk type human papillomavirus (hpv) infection is recognized as a necessary cause of cervical cancer. this study aimed to compare the hpv prevalence and risk factors between women residing in hong kong (hk) and guangzhou (gz) region of china. | 2011 | 21559276 |
| effect of actinomycin-d on the cell-cycle progression and the expression of p53, waf1/cip1, gadd45, and mdm-2 genes in human oral keratinocytes - implication of human papillomavirus infection. | exposure of human oral keratinocytes immortalized by transfection with 'high risk' hpv dna to chemical carcinogens converts the cells to malignant phenotype, but it does not transform normal cells. to investigate the underlying mechanism for different chemical carcinogen susceptibility of normal and the hpv-immortalized oral keratinocytes to genotoxic agent, we studied the progression of cell cycle and the expression of p53, waf1/cip1, gadd45 and mdm-2 genes in normal and in the hpv-immortalized ... | 1994 | 21559675 |
| current status of prostate-cancer research - development of in-vitro model systems (review). | prostate cancer is a major medical problem which is expected to affect over 200,000 us men in 1994. despite its widespread prevalence and the difficulties in clinical diagnosis and treatment of the disease, the contribution of environmental factors and the etiological mechanism of prostate cancer are poorly understood. a brief update on recent progress in cellular and molecular research of prostate cancer is provided. specific areas discussed include oncogenes (vas, myc, c-erbb-2 and bcl-2), tum ... | 1994 | 21559703 |
| clinical evaluation of polymerase chain reaction reverse hybridization assay for detection and identification of human papillomavirus type 16 variants. | background: isolates of hpv16 comprise six variants: european (eu), asian (as), asian-american (aa), north american (na), african-1 (af1), and african-2 (af2) with different carcinogenic potentials. highly reliable automatable techniques for hpv variant genotyping would be helpful to confirm the role of variants in cervical cancer in large epidemiological studies. objective: to validate the performance of a novel assay for identification of hpv16 variants. study design: the test is a multiplex p ... | 2011 | 21561803 |
| human papillomavirus infection in nasal polyps in a chinese population. | in order to determine the prevalence and genotype distribution of human papillomavirus (hpv) infection in patients with nasal polyps, a total of 204 patients with nasal polyps and 36 healthy controls were recruited in this study. genomic deoxyribonucleic acid (dna) was extracted from paraffin-embedded tissue sections. hpv dna genotyping was achieved by a flow-through hybridization and gene chip method. hpv infection was positively identified in 82 of 204 (40.2%) patients, while hpv dna was not f ... | 2011 | 21562117 |
| human papillomavirus vaccine introduction in low and middle income countries: guidance on the use of cost-effectiveness models. | abstract: background: the world health organization recommends that the cost-effectiveness of introducing human papillomavirus (hpv) vaccination is considered before such a strategy is implemented. however, developing countries often lack the technical capacity to perform and interpret results of economic appraisals of vaccines. to provide information about the feasibility of using such models in a developing country setting, we evaluated models of hpv vaccination in terms of their capacity, req ... | 2011 | 21569406 |
| genital human papillomavirus infection in patients with autoimmune inflammatory diseases. | treatment advances achieved over the last few years have radically changed the management of patients with autoimmune inflammatory diseases requiring conventional or biological immunosuppressive therapy. these diseases and the drugs used to treat them increase the rate of infections, including genital infections due to the human papillomavirus (hpv). genital hpv infections have been extensively studied in organ transplant recipients, hiv-infected patients, and patients with congenital immune def ... | 2011 | 21570889 |
| a protein profile study to discriminate cin lesions from normal cervical epithelium. | background: cervical intraepithelial neoplasia (cin), a frequently encountered disease caused by human papilloma virus (hpv) is often diagnosed in formaldehyde-fixed paraffin embedded (ffpe) punch biopsies. since it is known that this procedure strongly affects the water-soluble proteins contained in the cervical tissue we decided to investigate whether a water-soluble protein-saving biopsy processing method can be used to support the diagnosis of normal and cin. methods: cervical punch biopsies ... | 2011 | 21573931 |
| cancerous inhibitor of protein phosphatase 2a is overexpressed in cervical cancer and upregulated by human papillomavirus 16 e7 oncoprotein. | objectives: cancerous inhibitor of protein phosphatase 2a (cip2a) is a recently identified oncoprotein stabilizing c-myc and promoting cell proliferation and transformation. here we investigated the role of cip2a in cervical cancer in vivo and in vitro. methods: cip2a expression was assessed in normal cervical, cervical intraepithelial neoplasia (cin) i to iii and cervical cancer tissues by immunohistochemistry and rt-pcr. cell growth was explored by cell proliferation assay, colony formation as ... | 2011 | 21575984 |
| the impact of cytology screening and hpv vaccination on the burden of cervical cancer. | aim: to evaluate the impact of different strategies of human papillomavirus (hpv) vaccination on the burden of cervical cancer in singapore. methods: the incidence of cervical cancer was calculated using a markov model with inputs based on singapore data for the prevalence of hpv infection, socioeconomic characteristics and screening prevalence. the evaluation was performed for 10 scenarios: no screening, current opportunistic cytology screening, ideal optimal screening, universal adolescent h ... | 2011 | 21585695 |
| knowledge of pap smear, hpv and the hpv vaccine and the acceptability of the hpv vaccine by thai women. | aims: the primary prevention for cervical cancer, a human papilloma virus (hpv) vaccine, has been available in thailand for almost 3 years. the present study evaluates knowledge about the papanicolaou (pap) smear, hpv and the hpv vaccine and focuses on identifying predictors for the acceptability of the hpv vaccine. methods: a sample of 764 women attending the gynecology clinic at ramathibodi hospital, bangkok, was asked to answer a questionnaire on their personal background, their knowledge o ... | 2011 | 21585696 |
| should males be vaccinated against hpv? | 2011 | 21587022 | |
| correlation between human papillomavirus infection and clinicopathological parameters in anal canal carcinoma. | we evaluated human papillomavirus (hpv) dna in 17 anal canal tumors and its correlation with symptomatology, tumor extension and prognosis. five squamous carcinomas and 4 cloacogenic tumors resulted hpv+. statistical analysis showed no correlation between hpv infection and tumor morphology, lymph node involvement or prognosis, and no significant difference in the duration of symptoms between hpv+ and hpv- patients. hpv are involved in the pathogenesis of the tumors, but are not responsible for a ... | 1997 | 21590048 |
| cytopathic effects of human papillomavirus infection and the severity of cervical intraepithelial neoplasia : a frequency study. | cytopathic effects related to the human papillomavirus (hpv) infection are more frequently found in cervical intraepithelial neoplasia (cin) 1; however, there are indications that at least half the histological diagnoses of cin2 and cin3 include koilocytosis areas. the objective of this study was to evaluate the frequency of the cytological criteria suggestive of hpv infection in the cervical smears of women with a histological diagnosis of cin. one hundred and sixty-two women with abnormal cerv ... | 2011 | 21591275 |
| differential survival trends for patients with tonsillar, base of tongue and tongue cancer in sweden. | tonsillar, base of tongue and tongue cancer have similar anatomical and histopathological appearances but present differences in prognosis. human papillomavirus (hpv) is a known risk factor for tonsillar and base of tongue cancer, and a survival benefit has been shown for these tumors; however, hpv prevalence in tongue cancer is low. tonsillar, base of tongue and tongue cancer patients registered in the swedish cancer registry between 1960 and 2004 were followed from the date of cancer diagnosis ... | 2011 | 21592846 |
| ccnd1 rs9344 polymorphisms are associated with the genetic susceptibility to cervical cancer in chinese population. | cyclin d1, with a common g/a polymorphism in rs9344, is an essential regulator of the g1 phase in cell cycles and plays an important role in several tumor types, and the homology of cyclin d1 with human papillomavirus (hpv)-16 e7 brought our attention to ccnd1 gene in cervical cancer. a total of 738 native chinese subjects consist of 327 cases and 411 controls were enrolled in this study. ccnd1 genotyping was analyzed by polymerase chain reaction-restriction fragment length polymorphism (pcr-rfl ... | 2011 | 21594903 |
| green and black tea in relation to gynecologic cancers. | scope: observational studies have evaluated the relationship between green tea intake and cancers of the ovary and endometrium, but we are not aware of the published studies on green tea intake and risk of human papillomavirus (hpv)-related cancers of the cervix, vagina, or vulva. methods and results: a critical review of the published literature on tea intake and risk of ovarian and endometrial cancers was conducted. in meta-analyses, we report inverse associations for green tea intake and risk ... | 2011 | 21595018 |
| molecular epidemiology of hpv infection using a clinical array methodology in 2952 women in greece. | clin microbiol infect abstract: the molecular epidemiology of human papillomavirus (hpv) infection in a sample of greek women (n = 2952, mean age 42.2 ± 13.3 years) was examined. hpv prevalence was 50.7% (95% confidence interval, 48.8-52.6). the most frequent hpv types were hpv 53, 51 and 66 (10.2%, 9.4% and 9.3%, respectively). hpv positivity was associated with age, age of sexual debut, number of sexual partners and duration of sexual relationship, while marriage or multiparity protected again ... | 2011 | 21595788 |
| [papillomavirus and head and neck cancer.] | tobacco and alcohol consumption are the main risk factors for head and neck cancers. papillomavirus (hpv) infection was recently associated with the development of malignant tumors of the oropharynx, according to molecular and biological arguments. we describe the oncogenic mechanisms of hpv infections, the epidemiological and clinical aspects of associated head and neck cancers, their prognosis, and issues of specific therapeutic strategies. | 2011 | 21596407 |
| a case of multiple squamous cell papillomas of the trachea. | we report a case of 68-year-old woman suffering from breathlessness on exertion with stridor. a chest computed tomography showed a tumor arising from the posterior wall of the trachea. the diagnosis was squamous cell papilloma of the surgically removed tumor, which had caused the asphyxiation. after removal of the tumor, the patient received radical therapy: semiconductor laser transpiration. polymerase chain reaction (pcr) detected human papilloma virus (hpv) type 6, thought to be the cause of ... | 2011 | 21597426 |
| [significance for the detection of human papillomavirus dna in cervical atypical glandular cells.] | objective: to evaluate the potential link between high-risk human papilloma virus (hpv)dna testing and histological diagnosis in women referred for atypical glandular cells (agc) at pap smear. methods: all cervical cytological examinations with the diagnosis of agc between january 2007 and dec 2009 were identified by means of a computerized database in 97 patients. the histopathological results of cervix were analyzed by colposcopic biopsy, dilatation and curettage (d&c), cervical loop electrosu ... | 2011 | 21600120 |