Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| chemosensitization of the nitrosoureas by 2-nitroimidazoles in the subcutaneous 9l tumor model: pharmacokinetic and structure-activity considerations. | alterations of the pharmacokinetics and cytotoxic effects of the nitrosoureas, 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) and 1-(2-chloroethyl)-3-(cyclohexyl)-1-nitrosourea (ccnu) by the 2-nitroimidazoles, misonidazole (miso) and sr-2508 were investigated using the subcutaneous (sc) 9l tumor model in male fisher 344 rats. when 50 mg/kg of ccnu was given i.p., the peak plasma concentration of ccnu was about 3 micrograms/ml. ccnu was eliminated with biphasic kinetics that had a terminal half-time ... | 1990 | 2140824 |
| sequential ultrastructural podocytic lesions and development of proteinuria in serum sickness nephritis in the rat. | serum sickness nephritis was induced in fisher rats by immunization with egg albumin (ea) and correlations between immune complex deposition, alterations of podocytes and development of proteinuria were analysed. immunoelectron microscopy showed that ea, rat igg and c3 were confined to the electron-dense deposits (ds). from 3 weeks, when significant proteinuria had developed, the subepithelial region was filled with large numbers of ds on the peripheral capillary wall as well as in the paramesan ... | 1990 | 2146798 |
| [topical therapy of acute skeletal muscle diseases. results of a comparative study on piroxicam cream 1% versus diclofenac emulgel 1%]. | an open comparative study on 75 patients with the aim to compare efficacy and safety of two non steroidal antiinflammatory drugs for topic use, piroxicam 1% cream (38 patients) and diclofenac 1% emulgel (37 patients) in the acute musculoskeletal disorders (tendinitis, distortion, muscular disorders etc.) has been carried out. piroxicam has been administered at the dose of 0.5-1 g cream and diclofenac at the dose of 4 g emulgel, both 4 times a day for a period of 14 days. at baseline, 3rd, 7th an ... | 1990 | 2149533 |
| sex determination from the hyoid bone by means of discriminant analysis. | sex diagnosis of skeletal remains represents one of the main problems in the forensic osteological practice. the purpose of the paper was to apply discriminant analysis as the method of its solution--in the set of measurements carried out on the hyoid bone. classical procedure by r. a. fisher yielded the set of linear discriminant functions applicable also in cases of injured bones, which is the relatively frequent situation. information efficiency of the method proved to be quite satisfactory-- ... | 1990 | 2150289 |
| anesthesia and immunosuppression in an experimental model. | the purpose of the present work was to study: (1) if anesthesia induces changes in the helper/cytotoxic/suppressor t cell ratio in the rat spleen, and (2) if there is any difference between two anesthetic methods usually employed in rat experimentation. 50 fisher 344 rats were allotted into 5 groups. in group a (control), a splenectomy was performed in an average time of 3 min under ether anesthesia. in groups b1 and b2, the rats anesthetized for 1 h with ether (group b1) or with one single dose ... | 1990 | 2150373 |
| replication-dependent transactivation of the polyomavirus late promoter. | when a plasmid containing the wild-type polyomavirus intergenic regulatory region fused to the bacterial cat gene was introduced into mouse nih 3t3 cells along with a plasmid coding for the early viral proteins (t antigens), chloramphenicol transacetylase enzyme activity and mrna levels were increased about 10-fold over levels observed in the absence of early proteins. to investigate this transactivation phenomenon further, 11 specific deletion mutant derivatives of the wild-type parent plasmid ... | 1990 | 2154625 |
| neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake. | the intent of the present series of experiments was to better understand the events that produce a rapid adaptation of beta adrenergic and serotonin-2 (5-ht2) receptors when imipramine treatment and forced swim are combined in sprague-dawley rats. beta adrenergic and 5-ht2 receptors were evaluated at specific stages of the forced swim test with and without imipramine treatment. rapid changes in receptor binding were observed in saline-treated rats during specific stages of the test. the changes ... | 1990 | 2157002 |
| strain-specific determination of the degree of thyroid cell mhc class ii antigen expression: evaluation of established wistar and fisher rat thyroid cell lines. | the major histocompatibility complex (mhc) genes, primarily of the mhc class ii region, are linked to increased susceptibility to autoimmune thyroid disease in animals and humans. the quantity of mhc class ii antigens that are expressed on the appropriate cell surface, as well as their allotype, are of vital importance to immune function. we have, therefore, compared mhc class ii (rt1.d) gene activation in a newly available wistar rat thyroid (wrt) cell line (a thyroiditis-susceptible strain) wi ... | 1990 | 2167213 |
| increased phospholipase c-catalyzed hydrolysis of phosphatidylinositol-4,5-bisphosphate and 1,2-sn-diacylglycerol content in psoriatic involved compared to uninvolved and normal epidermis. | evidence suggests that the phospholipase c/protein kinase c signal transduction system participates in the regulation of epidermal cell growth and differentiation. psoriatic epidermis is characterized by hyperproliferation, defective differentiation, and inflammation. in this report, we have determined the activity of phospholipase c-catalyzed hydrolysis of phosphatidylinositol-4,5-bisphosphate (pip2) and 1,2-diacylglycerol content in normal and psoriatic involved and uninvolved epidermis. 1,2-d ... | 1990 | 2170539 |
| tyrosine-96 as a natural spectroscopic probe of the cytochrome p-450cam active site. | the previously described correlation between the ferric spin equilibrium of cytochrome p-450cam and the environmental polarity of tyrosine residues (fisher et al., 1986) has been further examined with the use of site-directed mutagenesis and active-site affinity reagents. whereas the wild-type demonstrates an increase in environmental polarity of approximately one tyrosine residue, the mutant protein y96f, in which tyr-96 has been changed to phe-96, demonstrates a lack of spin-state-dependent ch ... | 1990 | 2182119 |
| rudolph fisher: harlem renaissance physician-writer. | 1990 | 2187209 | |
| who was alice fisher? | 2004 | 2188218 | |
| changes in insulin receptors on methylcholanthrene-induced sarcoma during growth. | methylcholanthrene-induced sarcomas (mca-s) have different growth patterns in diabetic (d) and nondiabetic (nd) rats. diabetes delays the early phase of tumor growth and prolongs survival. this study evaluated mca-s growth and its relation to insulin receptors (ir) and glucose uptake. fisher 344 rats 150-200 g were assigned to two groups: diabetic tumor bearers (dtb, n = 26) and nondiabetic tumor bearers (ndtb, n = 18). diabetes was induced with iv streptozocin (40 mg/kg); mca-s was inoculated ( ... | 1990 | 2191169 |
| fluconazole compared with amphotericin b plus flucytosine for cryptococcal meningitis in aids. a randomized trial. | to compare the efficacy of fluconazole with amphotericin b plus flucytosine in the treatment of cryptococcal meningitis. | 1990 | 2197908 |
| inhaled or intravenous pentamidine therapy for pneumocystis carinii pneumonia in aids. a randomized trial. | to compare inhaled pentamidine with intravenous pentamidine for the treatment of pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome (aids). | 1990 | 2197910 |
| fetal umbilical artery doppler response to graded maternal aerobic exercise and subsequent maternal mean arterial blood pressure: predictive value for pregnancy-induced hypertension. | predictive tests for the identification of women at high risk of the development of preeclampsia are critical to allow the most appropriate preventive measures. preeclampsia is a vasospastic condition of pregnancy characterized by early and enhanced vascular reactivity to endogenous pressor agents. exercise tolerance testing with cycle ergometry to induce hemodynamic response measured with duplex doppler a/b ratio of the umbilical artery could unmask latent vascular pressor hypersensitivity. our ... | 2008 | 2206070 |
| promotion of colonic microadenoma growth in mice and rats fed cooked sugar or cooked casein and fat. | we studied the effect of cooked food components on the promotion of microadenoma growth in the colons of mice and rats. cf1 mice and fisher 344 rats were initiated with azoxymethane, with 152 mice receiving four weekly i.p. injections of 5 mg/kg, 59 rats receiving a single injection of 20 mg/kg, and 24 rats receiving 30 mg/kg. a week after the last injection, the animals were randomly assigned to one of eight diets with identical ingredients, but the three components, sucrose, casein, and beef t ... | 1990 | 2208161 |
| exogenous estrogen therapy for treatment of clomiphene citrate-induced cervical mucus abnormalities: is it effective? | clomiphene citrate (cc) may have an adverse effect on cervical mucus (cm) quality and quantity. a placebo-controlled study was performed to assess the effect of exogenous follicular phase estrogen (e) on cm. subjects qualified for inclusion by repeated demonstration of poor cm while on cc therapy as judged by spinnbarkeit, quantity, and viscosity. subjects were treated by a randomized, placebo-controlled format using: (1) oral micronized estradiol (e2), 2 mg; (2) conjugated es, 5 mg, or (3) plac ... | 1990 | 2209876 |
| tsh action on iodination in frtl-5 cells. | this study shows that the fisher rat thyroid cell line (frtl-5) can iodinate thyroglobulin (tg) in an selective way. the tg-iodination is tsh dependent and shows a optimum at 10-100 microu tsh/ml. intracellularly, tg and various other non tg-related proteins are iodinated in a tsh dependent fashion. tg added to the medium is specifically iodinated, this occurs already in microgram amounts, in contrast to many other proteins present in the medium. only albumin, present in mg amounts is clearly io ... | 1990 | 2210631 |
| evaluation of heartworm immunodiagnostic tests. | in this report, the use of appropriate statistical methods for the evaluation of heartworm immunodiagnostic tests is discussed. the evaluation of these tests is complicated by factors causing variation in sensitivity, specificity, accuracy, and predictive values of positive and negative test results. the primary sources of inconsistency are variation in the prevalence of heartworm infection among populations of dogs and the sensitivity of immunodiagnostic tests to various categories of heartworm ... | 1990 | 2211321 |
| in vitro synthesis of 16 alpha-hydroxyestrone by female rat liver microsomes: its possible role in the etiology of breast cancer. | liver homogenates from female rat strains (sprague-dawley, wistar and fisher) were incubated in a nadph regenerating medium in the presence of labelled and unlabelled estrone. liver microsomes isolated from male rats and female mice were used as positive controls. using hplc and paper chromatography, under the experimental conditions used it was found that liver homogenates from female rats were able to convert estrone to various metabolites such as 16 alpha-hydroxyestrone. in a mutagenicity ass ... | 1990 | 2214769 |
| influence of trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice. | the murine model of chronic chaga's myocardiopathy was developed in 201 inbred and outbred mice. the experimental groups consisted of 1st: 73 inbred akr and a/j mice inoculated with one of the following trypanosoma cruzi strains: peruvian (type i), 12 sf (type ii) or colombian (type iii); 2nd: 128 outbred swiss mice, chronically infected either with type ii or type iii strains isolated from human patients from different geographical areas. all t. cruzi strains were previously characterized by th ... | 1990 | 2215229 |
| the summarizing of clinical experiments by significance levels. | for a controlled clinical experiment in which two alternative treatments are compared, the statistical report often culminates in a significance test of the null hypothesis of no difference between the treatments, and significance at the 5 per cent level is taken as positive evidence of difference. it is argued that such an experiment serves primarily an inferential purpose; it is not a simple decision procedure, although its effect on practice may be considered in relation to ethical issues. st ... | 1990 | 2218173 |
| transcriptional regulation of messenger rna for ferritin heavy chain by thyrotropin. | thyrotropin increased the steady state levels of ferritin heavy chain messenger rna in cultured fisher rat thyroid (frtl5) cells by about 2.5-fold. thyrotropin also stimulated the transcription rate of ferritin h gene determined by "nuclear run-on" assay by roughly the same extent as mrna levels. thyrotropin showed no effect on the stability of the ferritin heavy chain mrna, which was suggested using actinomycin d. the results suggest that thyrotropin increases ferritin heavy chain mrna expressi ... | 1990 | 2222492 |
| [massive water infusion into the patient's trachea during the use of cascade type heated humidifier]. | a case of an inadvertent massive infusion of water via the humidifier module into the trachea during the use of cascade type heated humidifier is described. a fisher and paykel anesthetic humidifier was employed in the exhalation side of jackson rees type breathing circuit between the anesthesia machine and patient's endotracheal tube. during anesthesia for inguinal hernia, fresh gas flow was 6 liters per minute in the breathing circuit. humidifier module was inadvertently upside down, and the w ... | 1990 | 2232134 |
| absorption and metabolism of procaine by the rat small intestine. | the aim of this study was to obtain information about the absorption of procaine in the rat small intestine (fisher-parsons preparation). in the range from 0.25-10 mmol.l-1 procaine in the luminal perfusate, much more of the unchanged drug was absorbed in segments of the ileum than of the duodenum and jejunum. besides procaine, two metabolites, p-aminobenzoic acid (paba) and acetylated p-aminobenzoic acid (aaba), formed in the intestinal mucosa, appeared in the absorbate. with increasing substra ... | 1990 | 2234105 |
| effect of angiotensin ii infusion during normal pregnancy on flow velocity waveforms in the uteroplacental and umbilical circulations. | women destined to develop preeclampsia show an increased systemic pressor response to infused angiotensin ii, and the angiotensin sensitivity test has been accepted as an appropriate means of identifying these women. however, the effect of angiotensin ii infusion on uteroplacental blood flow is unknown and may be deleterious. patients undergoing angiotensin sensitivity tests as part of a protocol examining the effect of aspirin on the incidence of preeclampsia were studied with doppler velocimet ... | 1990 | 2234719 |
| an early 20th century view of nursing. | the novels of dorothy canfield fisher reflect the esteem with which nursing was held in the first half of the 20th century. though no longer widely read, these novels were, in their day, ranked with those of willa cather, pearl buck and edith wharton and are distinguished by their portrayal of nurses as strong, competent, independent, and compassionate role models for young women. | 2004 | 2235537 |
| comparison of phenytoin with noncompetitive n-methyl-d-aspartate antagonists in a model of focal brain ischemia in rat. | recent in vitro and in vivo experiments have suggested that excitatory amino acid antagonists, particularly those active at the n-methyl-d-aspartate receptor subtype, are effective in ameliorating ischemic injury due to their antiexcitotoxic activity. however, these drugs are also potent and effective in vivo anticonvulsants. the present experiments compared the noncompetitive n-methyl-d-aspartate antagonists phencyclidine and mk-801 with the anticonvulsant phenytoin in a model of focal brain is ... | 1990 | 2237985 |
| thoracic spinal fractures and aortic rupture: a significant and fatal association. | we analyzed the frequency of occurrence of traumatic aortic rupture (tar) in patients with and without thoracic spinal fractures. among 4,676 blunt chest trauma victims admitted to the hospital between 1972 and 1988, 148 (3.2%) suffered one or more thoracic vertebral fractures. there were 73 patients with one or more fractures of the first eight thoracic vertebrae (t1 to t8); of these 73, 4 also suffered tar (5.5%). there were 4,603 patients without fractures of t1 to t8, and 64 of these patient ... | 1990 | 2241385 |
| adjuvant-induced arthritis in rats. evidence that autoimmunity to homologous collagens types i, ii, ix and xi is not involved in the pathogenesis of arthritis. | we examined the sera of arthritic outbred wistar and sprague-dawley rats and inbred fisher 344 and wistar-lewis rats for autoantibodies to rat type i, ii, ix and xi collagens following the induction of arthritis with mycobacteria (mtb). although many sera collected over an extended time were assayed in addition to acid eluates of arthritic joints, convincing evidence for autoimmunity to collagen could not be demonstrated. instead, modest non-specific reactions were observed to collagen, irreleva ... | 1990 | 2242611 |
| liver genotoxic activity of an epoxide derivative of the hepatocarcinogenic beta-blocker dl-zami 1305. | a single administration of the sex-dependent hepatocarcinogenic beta-blocker dl-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (dl-zami 1305) induces dose-dependent liver dna damage, as evaluated by alkaline sucrose gradient analysis, in female but not in male fisher 344 rats. a single administration of the direct mutagenic epoxide-derivative of dl-zami 1305 3-methyl-2-nitro-1-(2,3-epoxypropoxy)-benzene induces dose-dependent dna damage in the liver of animals of both sexes. however, ... | 1990 | 2245411 |
| clinical and electrophysiological findings in two cases of miller fisher syndrome. | clinical, radiological and electrophysiological data in two patients with 'miller fisher syndrome' (mfs), characterized by ataxia, ophthalmoplegia and areflexia are reported. of the many tests performed only the electrophysiological findings provided any clue to the site of the lesions and the structure involved, showing a significant pattern of brainstem dysfunction. the authors discuss the role of central and peripheral lesion theory in the light of these data and stress that electrophysiologi ... | 1990 | 2246122 |
| evaluation of metastatic cardiac calcification in a model of chronic primary hyperparathyroidism. | recent reports have fueled an interest in the prevalence and significance of metastatic calcium deposition in patients with chronic hyperparathyroidism. experimental data are limited by the lack of suitable in vivo animal models. we have developed a model of marked hypercalcemia and overproduction of parathyroid hormone using somatic gene transfer. briefly, the process involves infection of cultured rodent fibroblasts (rat-1 cells) with a retroviral expression vector that contains the gene encod ... | 1990 | 2247829 |
| structure and oxidation-reduction behavior of 1-deaza-fmn flavodoxins: modulation of redox potentials in flavodoxins. | flavodoxins from clostridium beijerinckii and from megasphaera elsdenii with 1-carba-1-deaza-fmn substituted for fmn have been used to study flavin-protein interactions in flavodoxins. the oxidized 1-deaza analogue of fmn binds to apoflavodoxins from m. elsdenii and c. beijerinckii (a.k.a. clostridium mp) with association constants (ka) of 1.0 x 10(7) m-1 and 3.1 x 10(6) m-1, values about 10(2) less than the corresponding ka values for fmn. x-ray structure analysis of oxidized 1-deaza-fmn flavod ... | 1990 | 2261478 |
| [the miller-fisher syndrome (clinical report)]. | the authors present a case report of two female patients, aged 16 and 33. both patients had the same sudden onset of illness, with diplopia and nystagmus and very severe ataxia. the younger patient had absent tendon reflex, while the older one had the tendon reflex preserved. the younger patient had the triparesis present, both patients had no sphincter disorders. they did not have sensibility disturbances, except that the younger patient had hypesthesia of the soft palate (the motor function wa ... | 1990 | 2263312 |
| spike-and-wave neocortical patterns in rats: genetic and aminergic control. | spontaneously occurring and drug-induced high voltage spike-and-wave electroencephalogram patterns were examined in inbred rats of the fischer 344 and buffalo strains and of the random-bred sprague-dawley strain at different ages. in addition, tyrosine hydroxylase activity and dopamine d2 receptor density were determined in the substantia nigra, corpus striatum, olfactory tubercle and ponsmedulla areas of fisher 344 and buffalo animals. high voltage spike-and-wave episodes were present in 87.5% ... | 1990 | 2263319 |
| analysis of interleukin 2 and various effector cell populations in adoptive immunotherapy of 9l rat gliosarcoma: allogeneic cytotoxic t lymphocytes prevent tumor take. | recombinant interleukin 2 (ril-2) and various effector cell populations were used for adoptive immunotherapy in the fischer strain 9l rat gliosarcoma model. the in vivo cytotoxicities of nonspecifically activated lymphocytes and specifically activated cytotoxic t lymphocytes (ctls) were assessed in a modified in vivo neutralization (winn) assay. effector cells (10(6)) and 9l tumor cells (10(5] were combined with 10(4) units of ril-2 and stereotactically implanted into the right frontal centrum s ... | 1990 | 2263613 |
| [characteristics of the main risk factors of coronary disease among the population of warsaw and rural agricultural population of the tarnobrzeg province]. | basing on results of first screening of the pol-monica project in 1984 in two centres that is the tarnobrzeg province and two districts of polish capital warsaw (praga south and praga north) the level of 11 main coronary disease risk factors was compared in 2469 men and 2729 women. the following 5 risk factors were statistically significant for both men and women: the durnin index of body fat content, the total cholesterol concentration in the plasma, triglyceride level, numbers of daily meals. ... | 2007 | 2267362 |
| miller fisher syndrome in systemic lupus erythematosus. | we describe the first case of miller fisher syndrome, a guillain barré variant, complicating systemic lupus erythematosus. the symptoms and signs mimicked a brainstem syndrome. despite treatment with high dose gamma globulin, our patient worsened and required mechanical ventilation. after plasma exchange, the patient improved. | 1990 | 2273495 |
| [ablative versus conservative therapy of operable breast cancer]. | review about operative management of breast cancer. comparison between breast preserving therapy and mastectomy in respect of the results of the studies of veroneti and b. fisher. | 1990 | 2275289 |
| [guillain-barré syndrome. 15 pediatric cases]. | clinical features and outcome of 15 children with guillain-barré syndrome were retrospectively analyzed. in 53% of the patients there was an infectious illness previous to the neurologic symptoms and in five children the etiologic agent was demonstrated. motor deficit affecting limbs was the most common clinical presentation and facilal paralysis was the most frequent accompanying sign. one of these children developed the fisher syndrome variant. the outcome was excellent except in one case. we ... | 1990 | 2275491 |
| no difference in expression of chromosomal fragile sites in patients with solid malignant tumours and normal controls. | the frequency and distribution of rare and common chromosomal fragile sites in metaphases derived from peripheral lymphocytes were compared in 26 patients with malignant solid tumours and 24 normal controls. in order to avoid bias in evaluation, the identity of each individual as patient or control was disclosed only after the study was completed. rare heritable folic acid inducible fragile sites were found in five patients (2q13; 6p23; 8q22; 16p12) and two controls (8q22). common fragile sites ... | 1990 | 2278966 |
| professor sir ronald fisher, frs. | 2017 | 2279171 | |
| spiral ganglion cell endings in the cochlear nucleus of young and old rats. | the spiral ganglion cells (sgcs) forming the auditory nerve have been shown to degenerate with age in both human and animal models, presumably resulting in post-synaptic sites in the cochlear nucleus (cn) that have lost their inputs. the present study examined the morphological changes in the surviving sgc endings in the cn of aged animals. the auditory nerves of 2-3 mo and 25-26 mo male, fisher 344 rats were anterogradely labeled with horseradish peroxidase and the cn prepared histochemically. ... | 1990 | 2292496 |
| [morphological changes in fetal small intestine and pancreas implanted in fisher and august rats]. | fragments of fetal small intestine of fischer rats aged 16-20 days were implanted to rats aged 3 months of the same fischer strain (syngeneic implantation). the morphological changes in the implants were investigated. it has been shown that serious modifications of the implant including the neoplasm formation are possible during the evolution process. after syngeneic implantation of fetal pancreas to fischer and august rats under identical conditions no malignization of the implants was observed ... | 1990 | 2298141 |
| continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia. | focal cerebral infarction and edema were measured in rats (wistar, fisher 344, and spontaneously hypertensive strains) pretreated with nimodipine (2 micrograms/kg/min i.v.) or its vehicle and subjected to the tandem occlusion of the middle cerebral and common carotid arteries. animals awoke from anesthesia 10-15 min after onset of ischemia and continued to receive treatment over a 24-h survival period. cortical infarction and edema were quantified by image analysis of frozen brain sections proce ... | 1990 | 2298839 |
| prospective study on the prevalence of sudden infant death and possible risk factors in brussels: preliminary results (1987-1988). | a prospective study was carried out to assess the frequency of sudden infant death (sid) in the brussels area. the study was conducted between january and december 1987 on infants presented to the health clinics of the brussels "office de la naissance et de l'enfance" (one). the infants entered the study if: (a) they were born between january 1 and december 31, 1987; (b) they attended an one consultation in the brussels area between january 1987 and december 1988; (c) visits were repeated monthl ... | 1990 | 2303079 |
| enhancement of pancreatic and hepatic glutathione levels in rats during cyanohydroxybutene intoxication. | 1-cyano-2-hydroxy-3-butene (chb), a cruciferous plant product, is hepatotoxic, pancreatotoxic, and elevates glutathione (gsh) in liver and pancreas. whether gsh elevation is preceded by a depletion related to toxic insult, or whether toxicity and gsh elevation are unrelated, is not known. to evaluate the temporal relationship between toxicity and gsh levels, male fisher 344 rats (6/group) were given chb (200 mg/kg po) and killed up to 96 hr after dosing. at death, histological and ultrastructura ... | 1990 | 2307313 |
| convergence to spatial-temporal clines in the fisher equation with time-periodic fitnesses. | the asymptotic behavior as t----infinity of the solutions with values in the interval (0, 1) of a reaction-diffusion equation of the form (formula: see text) is studied. conditions on m which are satisfied when m is nonincreasing in mu and which imply that every solution converges to some periodic limit function are found. except in some very special and well-defined circumstances, the limit is the same for all solutions, so that it is a global attractor. this global attractor may be one of the ... | 1990 | 2307914 |
| [the choice of the method of anesthesia as a risk factor in the femoral fracture near the hip joint in elderly patients]. | between january 1983 and december 1988, 317 patients with fractures near the hip joint were operated upon. in a retrospective study we compared 180 patients with general anesthesia (an) and 137 patients with spinal anesthesia (ra). the average age of patients with ra was 80.5 and with an 79.8 years. the preoperative management was done by an internist. the operation followed at an average of 2.8 days (tables 1, 2). all patients were placed into 3 risk groups, based on after preoperative cardiac ... | 1990 | 2310007 |
| effects of 1,3-dichloropropene on the kidney of fisher 344 rats after pretreatment with diethyl maleate, buthionine sulfoximine, and aminooxyacetic acid. | acute nephrotoxicity of cis/trans-1,3-dichloropropene (dcp) was assessed in male fisher 344 rats. pretreatment of rats with corn oil, aminooxyacetic acid (aoa), buthionine sulfoximine (bso), or diethyl maleate (dem) was given intraperitoneally 1 h or 4 h prior to injection of dcp. doses of dcp were 0, 25, 50, and 75 mg/kg intraperitoneally (4-5 animals per dose/pretreatment group). urine was collected for 24 h. excretion of creatinine, phosphorus, protein, n-acetylglucosaminidase (nag), and the ... | 1990 | 2313738 |
| a model of reversible obstructive jaundice in the rat. | a model of reversible, extrahepatic biliary obstruction is described. vessel loop blockade of the biliary tree results in obstructive jaundice while removal of the exteriorized vessel loop provides internal biliary drainage without subsequent laparotomy. this technique combined with a system for chronic venous infusion and arterial blood sampling in the unrestrained rat is ideal for long-term metabolic studies of obstructive jaundice. male fisher 344 rats (275-350 g) underwent either the combine ... | 1990 | 2314093 |
| effect of aging on intestinal biotin transport in the rat. | the influence of aging of biotin intestinal transport was examined in fisher 344 rats (3- 12- and 24-month old) using a brush border membrane vesicle (bbmv) technique. in all age groups examined, transport of biotin as a function of concentration was saturable in the presence of a na+ gradient (out greater than in), but was lower and linear in the presence of a choline gradient (out greater than in.). the vmax of the biotin transport process was found to be significantly (p less than 0.01) highe ... | 1990 | 2318284 |
| a second thyroglobulin messenger rna species (rtg-2) in rat thyrocytes. | a 0.95-kilobase (kb) thyrocyte rna, initially detected in our 1b-6 subclone of fisher rat thyrocytes (frtl-5) using an oligonucleotide probe complementary to the 5' end of rat thyroglobulin (tg) mrna, was also detected in cultured thyrocytes of the wistar rat (wrt cells) and in freshly isolated normal rat thyroid tissue. this transcript was thyroid specific and as abundant as the previously characterized 9.0-kb tg mrna in the cultured thyroid cells under the growth conditions employed. the small ... | 1990 | 2325666 |
| genitalia in human figure drawings: childrearing practices and child sexual abuse. | to replicate and explore the associations of drawing genitalia on a human figure, child-rearing practices, and a history of alleged sexual abuse, we designed a cross-sectional study of 109 alleged child sexual abuse victims, ages 3 through 8 years, and a group of 109 comparison children matched for age, sex, race, and socioeconomic status but with no history of abuse. a standardized format was used to collect drawings, administer the peabody picture vocabulary test, and gather background data on ... | 1990 | 2329432 |
| evidence that cyclosporine prevents rejection and recurrent diabetes in pancreatic transplants in the bb rat. | cyclosporine prevents the development of diabetes in spontaneously diabetic bb rats and nod mice. however, islet transplants have been shown to be subject to immunologic destruction in hosts treated with csa and anti-cd4 antibody or those rendered tolerant to donor antigens. this study determines whether the minimum dose of csa necessary to prevent rejection of pancreatic transplants will also prevent recurrent diabetes in pancreas transplants in bb rats. lewis recipients promptly reject bn (n = ... | 1990 | 2336700 |
| infrequent and limited-symptom panic attacks. | due to their prevalence and relationship to agoraphobia, panic attacks are receiving considerable attention. the dsm-iii requires that they include at least four associated symptoms and occur at least weekly for a diagnosis of panic disorder. this study of panic symptoms and frequency in 68 panic sufferers addresses the validity of these dsm-iii requirements in terms of symptom patterns and phobic avoidance. using chi-square, fisher, and t-test analyses, this study found no clinical distinction ... | 1990 | 2338539 |
| mri characterization of 9l-glioma in rat brain at 4.7 tesla. | in vivo estimation of intracranial tumor progression is important in tumor treatment response studies in animal models. high resolution mr images at 4.7 t of 9l-gliomas stereotactically implanted in fisher-344 rat brains were obtained. due to elongation of t1 at higher fields, tissue contrast is diminished in t1-weighted images. however, normal anatomy and vasogenic edema are clearly discerned in t2-weighted images (echo times of greater than 50 ms and recycle times of greater than 2 sec). tumor ... | 1990 | 2338899 |
| loss of muscarinic m1 receptors with aging in the cerebral cortex of fisher 344 rats. | age-related changes in central cholinergic muscarinic receptors were measured in young (3-6 month), middle-aged (15-17 month), and aged (22-26 month) male fisher 344 rats by receptor binding techniques. using [3h]-quinuclidinyl benzilate as the ligand, a significant decrease (14-19%) in the number of muscarinic cortical receptors was measured in aged rats compared to both young and middle-aged rats. with the selective m1 antagonist, [3h]-pirenzepine, a 17% decrease in receptor density was observ ... | 1990 | 2339151 |
| mathematical analysis of cell-target encounter rates in three dimensions. effect of chemotaxis. | efficient and rapid immune response upon challenge by an infectious agent is vital to host defense. the encounter of leukocytes (white blood cells of the immune system) with their targets is the first step in this response. analysis of the kinetics of this process is essential not only to understanding dynamic behavior of the immune response, but also to elucidating the consequences of many leukocyte functional abnormalities. the motion of leukocytes in the presence of targets typically involves ... | 1990 | 2340340 |
| dose-response relationship between o6-methylguanine formation in clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | the relationship between the formation of o6-methylguanine (o6mg) and the induction of lung, liver, and nasal tumors in the fisher 344 rat by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk) was examined in a dose-response study. animals were treated for 20 wk (3 times/wk) with concentrations of nnk ranging from 0.03 to 50 mg/kg to induce tumors. steady-state concentrations of o6mg were quantitated, and cytotoxicity was assessed in target cells and tissues af ... | 1990 | 2340522 |
| glutathione s-transferase subunit induction patterns of brussels sprouts, allyl isothiocyanate and goitrin in rat liver and small intestinal mucosa: a new approach for the identification of inducing xenobiotics. | effects of brussels sprouts (2.5-30%), allyl isothiocyanate (0.03 and 0.1%) and goitrin (0.02%), in the diet, on the glutathione s-transferase subunit pattern in the liver and small intestinal mucosa of male fisher rats were investigated. a statistically significant linear relationship was found between the amount of brussels sprouts in the diet and the induction of glutathione s-transferase subunits in two experiments. increases in total activity of glutathione s-transferases towards 1-chloro-2 ... | 1990 | 2341092 |
| regrowth of damaged neurosecretory axons to fenestrated vessels of implanted peripheral tissues. | a major target of neurosecretory axons (nsa) is the basal lamina around fenestrated blood vessels (fbv) in the neural lobe of the pituitary gland. we have posed the question of whether there is neurovascular specificity. do mature, regenerating nsa terminate selectively on the fbv of the neural lobe compared with the fbv of other tissues that normally are not innervated by nsa? three types of tissue were transplanted between inbred fisher rats. fragments, about 1 mm3, of pineal, adrenal medulla, ... | 1990 | 2343374 |
| root morphology of mandibular premolars in human 45,x females. | the teeth of 87 finnish 45,x females, 60 of their first-degree relatives and 87 normal females were examined. the presence of separate mesial and distal root canals and separate root apices was noted from orthopantomograms. of the 45,x females, 40 (or 46%) had lower premolars with separate root canals; 30 individuals in first and 28 in second premolars. the number of first and second premolars with separate mesial and distal root canals was 40 and 43, and of those also showing separate apices, 2 ... | 1990 | 2344286 |
| in vivo dental plaque-forming ability and cariogenicity of the bacterium streptococcus bovis in gnotobiotic rats. | germ-free fisher rats, fed on a high sucrose diet, were monoinfected with streptococcus bovis strains. high levels of fissure caries were formed by three strains; one strain produced moderate levels; another produced only very low levels. no strain could produce approximal or buccal/lingual lesions. all strains could colonize the fissures of teeth in the lower jaw, as shown by scanning electron microscopy. the most cariogenic strains were associated with caries scores similar to those of strep. ... | 1990 | 2344292 |
| proteoglycans synthesized by human glomerular mesangial cells in culture. | human fetal kidney mesangial cells were cultured for 24 h in the presence of 3h-amino acids and [35s] sulfate and chased for 24 h in nonradioactive medium. incubation medium and cell layer proteoglycans were purified twice by high performance liquid chromatography-deae chromatography followed by gel filtration chromatography. the major medium 35s-macromolecules were chondroitin/dermatan-35so4 proteoglycans. a small, sepharose cl-6b kav 0.14 dermatan-35so4 proteoglycan was detected in the labelin ... | 1990 | 2345181 |
| chronic diarrhoeal illness in us peace corps volunteers. | chronic diarrhoea of unknown aetiology is increasingly recognized as a problem in international travellers, and has been reported in us peace corps volunteers. in december 1987, we surveyed all peace corps medical officers to determine the magnitude of this problem and obtain preliminary data on potential risk factors. a rate of nine cases of chronic diarrhoea per 1000 volunteers per year was reported by medical officers representing 4607 volunteers in 43 countries. the highest rates were report ... | 1990 | 2351516 |
| substrate alterations in a sarcoma-bearing rat model: effect of tumor growth and resection. | the time course of plasma substrate level alterations in the tumor-bearing (tb) host and their relationship to tumor burden or weight loss has not been well defined. plasma glucose, lactate, pyruvate, cholesterol, triglycerides, acetoacetate, beta-hydroxy butyrate, and glycerol levels were measured in postabsorptive tb and nontumor-bearing (ntb) male fisher 344 rats at weekly intervals for 5 weeks. chronically starved rts (cs) had plasma substrates measured at week 3 and compared with tb and ntb ... | 1990 | 2352423 |
| chimeric analysis of the site of lurcher gene action with respect to glial enzyme expression. | immunocytochemical analysis of aggregation chimeras made using either of the mutants, lurcher or purkinje cell degeneration, previously showed that only bergmann glia close to surviving purkinje cells expressed an apparently normal level of the enzyme, glycerol-3-phosphate dehydrogenase (gpdh) (fisher and mullen, 1988). in the present study, aggregation chimeras were made using embryos from a b6d2 hybrid mouse strain carrying the lurcher (lc/+) mutation and homozygous for an allele specifying a ... | 1990 | 2358967 |
| role of calcium in adrenergic neurochemical transmission in the aging heart. | the effect of modification of extracellular ca2+ concentration ([ca2+]0), the administration of the neuronal ca2+ channel blocker, omega-conotoxin, and the calcium (ca2+) ionophore, ionomycin, were examined in the isolated heart of male fisher-344 rats 6 and 24 months of age. hearts with the right cardiac sympathetic nerve intact were isolated and perfused with krebs-ringer solution containing cocaine (10(-6) m) to block uptake 1, metanephrine (10(-6) m) to block uptake 2 and yohimbine (3 x 10(- ... | 1990 | 2359031 |
| preventing preterm birth in twin gestation: home uterine activity monitoring and perinatal nursing support. | in this investigation, 45 women with twin gestations in four centers were randomly assigned to either daily home uterine activity monitoring and perinatal nursing support (19) or an education group (26). patients in the home uterine activity monitoring and perinatal nursing support group monitored uterine activity twice daily, transmitted the data each day, and had 24 hour-a-day access to nursing support. education patients were counseled regarding the common signs and symptoms of preterm labor. ... | 1990 | 2359575 |
| pancreatic hepatocytes in fischer and wistar rats induced by repeated injections of cadmium chloride. | the effects of multiple sc injections of cadmium chloride (cdcl2) on the pancreas of two rat strains (wistar [wf/ncr] and fischer [f344/ncr]) were studied by histological and immunohistochemical examinations. a high incidence of hepatocytic foci occurred within the pancreata of both strains that was associated with this cadmium exposure. although pancreatic hepatocytes (ph) were found in both strains, wistar rats were more susceptible to cadmium-induced ph formation while showing more tolerance ... | 1990 | 2360204 |
| analysis of capillary geometry in rat subepicardium and subendocardium. | the sustained high-energy turnover of cardiac muscle presents a formidable challenge to the o2 delivery systems. one major determinant of blood-tissue gas exchange potential is capillary surface area per volume of muscle fiber, sv(c,f). estimation of sv(c,f) necessitates quantification of capillary orientation. capillary geometry was analyzed systematically in subepi- (epi) and subendocardium (endo) of glutaraldehyde perfusion-fixed rat heart (n = 4). on 1-micron sections cut rigorously transver ... | 1990 | 2375407 |
| exogenous nerve growth factor increases the activity of high-affinity choline uptake and choline acetyltransferase in brain of fisher 344 male rats. | the objective of this study was to determine the effect of age and chronic intracerebral administration of nerve growth factor (ngf) on the activity of the presynaptic cholinergic neuronal markers hemicholinium-sensitive high-affinity choline uptake (hacu) and choline acetyltransferase (chat) in the brain of fisher 344 male rats. in 24-month-old rats, a substantial decrease in chat activity (30%) was measured in striatum, and decreases in hacu were found in frontal cortex (28%) and hippocampus ( ... | 1990 | 2384747 |
| [a study of the sequelae of perinatal hypoxia and convulsions in full-term newborn infants]. | perinatal hypoxia may result in neuromotor handicaps. the occurrence of convulsions after perinatal hypoxia is regarded as a bad prognostic sign. thirty-two full-term babies with perinatal hypoxia were studied retrospectively. post-hypoxic convulsions were seen in 20 newborns. in 26 out of 29 survivors follow-up assessments were made between 2 months and 2 years of age. severe neuromotor abnormalities were demonstrated in 10 out of 19 patients with post-hypoxic convulsions, whereas no abnormalit ... | 1990 | 2385299 |
| hemorrhage in intracerebral arteriovenous malformations: angiographic determinants. | the most serious and frequent complication of intracranial arteriovenous malformations (avms) is intracranial hemorrhage. identification of patients at greatest risk for intracranial bleeding would be beneficial. detailed analysis of vascular architecture was performed in 65 patients with intracranial avms to identify the vascular characteristics that correlated with hemorrhage. fifteen characteristics were assessed. hemorrhage was present in 45 patients (69%). the following characteristics corr ... | 1990 | 2389040 |
| the barrier inventory: a validity study. | the barrier (b) inventory is a 37 item test based on the mmpi and measuring the b personality trait as conceived by fisher. the validity of the inventory was tested by having the subjects (n = 94) complete it and answer a series of inkblot reproductions. in fact, according to fisher, inkblot test responses are a useful means to assess the b trait. correlation between the results of the two tests was high (.74). | 1990 | 2390228 |
| miller fisher syndrome associated with q fever. | a 51 year old woman with pneumonia developed miller fisher syndrome. indirect immunofluorescence tests showed antibodies against coxiella burnetti. miller fisher syndrome associated with q fever has not been described previously. | 1990 | 2391529 |
| sexual selection unhandicapped by the fisher process. | a population genetic model of sexual selection is constructed in which, at equilibrium, males signal their quality by developing costly ornaments, and females pay costs to use the ornaments in mate choice. it is shown that the form of the equilibrium is uninfluenced by the fisher process, that is, by self-reinforcement of female preferences. this is a working model of the handicap principle applied to sexual selection, and places zahavi's handicap principle on the same logical footing as the fis ... | 1990 | 2402152 |
| randomized prospective trial comparing the native prothrombin antigen with the prothrombin time for monitoring oral anticoagulant therapy. | the dosage of the anticoagulant warfarin sodium is based upon the prolongation of the prothrombin time into an optimal therapeutic range. we have developed a new assay for the native prothrombin antigen that measures the fully gamma-carboxylated prothrombin using a radioimmunoassay. based on preliminary data that indicated that the native prothrombin antigen predicted both bleeding and thrombotic complications more accurately than the prothrombin time in patients anticoagulated with warfarin sod ... | 1990 | 2403824 |
| morphometric, densitometric and flow cytometric criteria for the automated classification of thyroid lesions. | an automated classification of 73 thyroid lesions using a logical and mathematical approach was attempted. densitometric, morphometric and flow cytometric parameters were used in fisher linear discriminant functions to separate goiters or normal thyroids from adenomas and from carcinomas; the combination of this approach with binary discrimination improved the initial classification to a final efficiency of 81%. this approach, which is useful for classifying individual cells, was thus insufficie ... | 2008 | 2405871 |
| mutational activation of the cellular harvey ras oncogene in rat esophageal papillomas induced by methylbenzylnitrosamine. | epidemiological studies have demonstrated a strong association between human esophageal cancer and exposure to n-nitroso carcinogens. esophageal tumors can be induced in experimental animals, especially in rats, by many n-nitroso carcinogens. in the present study, rat esophageal tumors induced by methylbenzylnitrosamine (mbna) and mbna-transformed esophageal cell lines were analyzed for activated protooncogenes. dnas from four fisher 344 rat esophageal papillomas were examined for their ability ... | 1990 | 2406014 |
| contact dermatitis: a festschrift for dr. alexander a. fisher. | 1990 | 2406056 | |
| anecdotal, historical and critical commentaries on genetics. r. a. fisher, a centennial view. | 1990 | 2407609 | |
| somatic antigens of pseudomonas aeruginosa. the structure of the o-specific polysaccharide chains of lipopolysaccharides of p. aeruginosa serogroup o4 (lányi) and related serotype o6 (habs) and immunotype 1 (fisher). | acidic o-specific polysaccharides were isolated on mild acidic degradation of lipopolysaccharides of pseudomonas aeruginosa serotypes o4a,b, o4a,c, o4a,d (lányi classification) and serologically related to them serotype o6 (habs classification) and immunotype 1 (fisher classification). the polysaccharides had identical monosaccharide composition and were built up of l-rhamnose, 2-acetamido-2,6-dideoxy-d-glucose,2-formamido-2-deoxy-d-galacturonic acid and 2-acetamido-2-deoxy-d-galactouronamide re ... | 1985 | 2410275 |
| effects of interferon on differentiation of normal and tumor cells. | as described in this review, both partially purified and recombinant interferons are potent modulators of differentiation in diverse cell culture systems (table 2). depending on the target cell, interferon exerts either an inhibitory or an inductive effect on cell differentiation. in certain myeloid leukemic cells, such as hl-60, interferon by itself is growth suppressive but does not induce cell maturation, whereas in combination with inducers of differentiation, such as dmso, tpa or retinoic a ... | 1985 | 2412243 |
| myelin basic protein in fisher syndrome. | 1985 | 2413179 | |
| rat lung macrophage tumor cytotoxin production: impairment by chronic in vivo cigarette smoke exposure. | macrophages in the presence of bacteria-derived lipopolysaccharide (lps) stimuli produce a soluble cytotoxin which is toxic to tumor cells. in this study, we examined various parameters of cytotoxin production from pulmonary lavage cells obtained from fisher 344 cesarean-derived rats. cultures of macrophages were derived from pulmonary lavage cells and stimulated in vitro with lps. cytotoxin production was assayed in vitro using an l-929 cell target assay. pulmonary lavage preparations contained ... | 1985 | 2413988 |
| characteristics of normal rat mammary epithelial cells and n-ethyl-n-nitrosourea-induced mammary adenocarcinoma cells grown in culture. | the characteristics of normal mammary epithelial cells derived from lewis and sprague-dawley rats and n-ethyl-n-nitrosourea (enu)-induced mammary gland adenocarcinoma cells derived from sprague-dawley (cd) and fisher (cdf) rats and grown in culture were compared. after collagenase treatment, the rat mammary epithelial cell aggregates were placed in a hormone-supplemented medium. the normal mammary epithelial cells (ne) attached to the surface of the dish within 50 hours, whereas the mammary aden ... | 1985 | 2415045 |
| [combination therapy (hypervolemia, fluosol-da 20%, hypertension) in the treatment of symptomatic vasospasm]. | combination therapy of (1) hypervolemia with albumin (1 g/kg/day), (2) artificial blood substitute (fluosol-da 20%, 10 ml/kg/day) and (3) induced hypertension was performed for the treatment of symptomatic vasospasm. outcome was compared between thus treated patients (treated group) and those without specific treatment (non-treated group) in (1) 30 patients presenting with vasospasm who were planned to undergo delayed operation (delayed operation group), (2) 23 patients undergoing early operatio ... | 1986 | 2419780 |
| friend virus-specific cytotoxic t lymphocytes recognize both gag and env gene-encoded specificities. | we have constructed a series of "synthetic" target cell lines for an analysis of the specificity of anti-friend virus (fv) ctl. our results show that murine h-2 genes and individual retroviral genes can be stable expressed in fisher rat embryo (fre) cells, and that their products have the potential to form target structures recognized by mouse ctl. cells expressing h-2db and either the env or gag genes of one component of fv, helper friend murine leukemia virus (fmulv), were lysed by anti-fv ctl ... | 1986 | 2425028 |
| studies on high-affinity [3h]substance p binding sites in bovine pineal gland. | the presence of substance p in numerous mammalian pineal glands prompted us to search for its binding sites in the bovine pineal gland. the binding assays to pineal membrane were carried out in polypropylene microcentrifuge tubes in a final volume of 500 microliters of 50 mm tris-hcl buffer (ph 7.4) containing aliquots of 200-500 micrograms protein, 0.02% bsa, 6 micrograms/ml chymostatin, 4 micrograms/ml leupeptin, 40 micrograms/ml bacitracin, 5 mm mncl2, and 50 microliters of [3h]substance p (3 ... | 1986 | 2430788 |
| growing familiarity with the test situation augments the vigilance deficit of aged rats. | quantitative eeg profiles of aged and of young-adult fisher-344 rats were studied over 10 consecutive recording (3 h) sessions. the individual recording sessions were spaced regularly over a 6-week period. in the aged rats, in recordings from both the frontal cortex and dorsal hippocampus, the eeg characteristics of a vigilance deficit state increased in prominence up through 8 recording sessions before a stable level was reached. a similar trend was not seen in the young-adult rats; instead, th ... | 1987 | 2431885 |
| immunochemical studies of human erythropoietin using site-specific anti-peptide antibodies. identification of a functional domain. | anti-peptide antibodies that bind to the amino terminus of human erythropoietin (residues 1-26) do not inhibit the hormone's biological activity, indicating that this region of the protein does not play a role in receptor recognition (sytkowski, a. j., and fisher, j. w. (1985) j. biol chem. 260, 14727-14731). we have now identified six other regions of the primary sequence that are relatively hydrophilic and, therefore, have a higher probability of being accessible to such antibody probes. antib ... | 1987 | 2433274 |
| effects of chemistry, manufacturing and concentration of the dye basic fuchsin regarding its use in quantitative cytophotometry. | four separately manufactured preparations of basic fuchsin were compared to determine the effects of concentration, chemistry, and the manufacturing process for their quantitative value in the nuclear feulgen reaction. in order to make the necessary comparisons, the two wavelength method of quantitative cytophotometry was employed to analyse each stain application regarding dna measurements. chicken erythrocytes, and myxamoebae and plasmodia of didymium iridis were employed as experimental tissu ... | 1987 | 2438091 |
| reversing the detrimental effect of adriamycin on skin grafts in rats. | we evaluated in a rat model the effects of a homologous fibrin glue in reversing the effects of adriamycin on adherence and take of skin grafts. a total of 40 male fisher rats were used in the study. during the first phase of the experiment, the animals were assigned to either group i (n = 10) receiving normal saline or group ii (n = 10) receiving 6 mg/kg adriamycin by tail vein injection 24 hours before surgery. skin grafts with and without fibrin glue were placed over wounds in the backs of th ... | 1987 | 2443938 |
| therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131i-radiolabeled murine monoclonal antibody in a human glioma xenograft model. | the development of mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. mab 81c6, an igg2b immunoglobulin, which defines an epitope of the glioma-associated extracellular matrix protein tenascin, has been shown to bind to human glioma cell lines, glioma xenografts in nude mice, and primary human gliomas, but not to normal adult or fetal brain. to test the therapeu ... | 1988 | 2446747 |
| identification of kallikrein in cultures of adult renal cells. | cortical tubular cultures enriched with distal segments were prepared from the kidney of adult fisher 344 rats bearing thyroid tumors. after two years of cultivation (20 passages) cell monolayers contained immunocytochemically detectable cytokeratin and kallikrein material in their cytoplasm. furthermore cell pellets showed a true renal type of kininogenase activity corresponding to active kallikrein which ranged from 22.3 to 1.5, and total kallikrein from 29.9 to 2.8 pg kinins/min per mg of pro ... | 1987 | 2446783 |
| effect of digitoxin on cardiac arrhythmias in hemodialysis patients. | digitoxin is considered a risk factor for ventricular arrhythmias in hemodialysis patients. in a randomized, crossover controlled study, 55 hemodialysis outpatients with sinus rhythm were prospectively investigated in two 48-h periods of electrocardiographic monitoring, one on and one off digitoxin or vice versa. the frequency of ventricular ectopic beats (mean +/- sd) which were found in 31 of 55 patients (56%), was slightly higher on hemodialysis (10 +/- 28 beats/h) than in the following 20 h ... | 1987 | 2447325 |