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zika virus advice for mountaineers: a uiaa medcom consensus advice sheet.hillebrandt, david, paul richards, andy clark, and dominique jean. zika virus advice for mountaineers: a uiaa medcom consensus advice sheet. high alt med biol. 17:70-71, 2016.-with the current media coverage of the spread of zika virus from africa and asia to central and south america and its possible relationship with fetal abnormalities, uiaa medcom has produced an advice sheet for mountaineers visiting risk areas.201627081746
membrane feeding of dengue patient's blood as a substitute for direct skin feeding in studying aedes-dengue virus interaction.understanding the interaction between aedes vectors and dengue viruses (denv) has significant implications in determining the transmission dynamics of dengue. the absence of an animal model and ethical concerns regarding direct feeding of mosquitoes on patients has resulted in most infection studies using blood meals spiked with laboratory-cultured denv. data obtained from such studies may not reflect the natural human-mosquito transmission scenario. this study explored the potential of using me ...201627083158
us agency says zika virus causes microcephaly. 201627083694
neuroimaging findings of babies with microcephaly and presumed congenital zika virus infection. 201627083981
[several issues on the epidemiology of zika virus disease].zika virus belongs to aedes mosquito-borne flavivirus. in response to the current cluster of congenital malformations (microcephaly) and other neurological complications (guillain-barré syndrome) that could be linked to zika virus infection, who declares that zika virus is of global public health importance. data sources were from peer review articles and who documents. the sources of zika virus infection would include patients, people with asymptomatic infections and primates. the infectious pe ...201627087204
[zika virus as a new threat to the health and life].the newly emerging pathogens are increasingly becoming a threat to health and life, as the cause of epidemic infections. in the last three years there were outbreaks caused by zika virus, which was transmitted by mosquitoes mainly from the region of south america. however, reports who and cdc indicate that infection has now reached to most countries of the world, including european countries. the clinical picture of what is observed during the infection is not very distinctive, because apart fro ...201627088194
tropical islands as new hubs for emerging arboviruses. 027088243
mass gatherings and the spread of respiratory infections. lessons from the hajj.the mass gathering of people is a potential source for developing, propagating, and disseminating infectious diseases on a global scale. of the illnesses associated with mass gatherings, respiratory tract infections are the most common, the most easily transmitted, and the most likely to be spread widely beyond the site of the meeting by attendees returning home. many factors contribute to the spread of these infections during mass gatherings, including crowding, the health of the attendees, and ...201627088298
phylogeny of zika virus in western hemisphere, 2015. 027088323
projecting month of birth for at-risk infants after zika virus disease outbreaks.the marked increase in infants born with microcephaly in brazil after a 2015 outbreak of zika virus (zika virus) disease suggests an association between maternal zika virus infection and congenital microcephaly. to project the timing of delivery of infants born to mothers infected during early pregnancy in 1 city in bahia state, brazil, we incorporated data on reported zika virus disease cases and microcephaly cases into a graphical schematic of weekly birth cohorts. we projected that these birt ...027088494
asian genotype zika virus detected in traveler returning to mexico from colombia, october 2015. 027088574
detection of zika virus in semen. 027088817
isolation of zika virus from febrile patient, indonesia. 027088970
zika virus ns1 structure reveals diversity of electrostatic surfaces among flaviviruses.the association of zika virus (zikv) infections with microcephaly has resulted in an ongoing public-health emergency. here we report the crystal structure of a c-terminal fragment of zikv nonstructural protein 1 (ns1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. comparison with west nile and dengue virus ns1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfaces, thus possibly ...201627088990
spectrum of viral pathogens in blood of malaria-free ill travelers returning to canada.malaria is the most common specific cause of fever in returning travelers, but many other vectorborne infections and viral infections are emerging and increasingly encountered by travelers. we documented common and emerging viral pathogens in malaria-negative specimens from ill travelers returning to canada. anonymized, malaria-negative specimens were examined for various viral pathogens by real-time pcr. samples were positive for herpes simplex viruses 1 or 2 (n = 21, 1.6%), cytomegalovirus (n ...027089008
fatal sickle cell disease and zika virus infection in girl from colombia. 027089120
once and future epidemics: zika virus emerging. 201627089202
detection of autochthonous zika virus transmission in sincelejo, colombia. 027089253
mapping global environmental suitability for zika virus.zika virus was discovered in uganda in 1947 and is transmitted by aedes mosquitoes, which also act as vectors for dengue and chikungunya viruses throughout much of the tropical world. in 2007, an outbreak in the federated states of micronesia sparked public health concern. in 2013, the virus began to spread across other parts of oceania and in 2015, a large outbreak in latin america began in brazil. possible associations with microcephaly and guillain-barré syndrome observed in this outbreak hav ...201627090089
zika virus: a new human teratogen? implications for women of reproductive age.in 2015 an unprecedented increase of reports of newborns with microcephaly in brazil made news headlines around the world. a possible etiological association with prenatal maternal infection by zika virus (zikv) was suggested based on temporal and geographic distribution of zikv infection and the subsequent increase in the reports of microcephaly cases. here we discuss zikv as a new human teratogen, with comments on potential treatment options.201627090438
prenatal brain mri of fetuses with zika virus infection.an outbreak of zika virus was observed in french polynesia in 2013-2014. maternal zika virus infection has been associated with fetal microcephaly and severe cerebral damage.201627090801
from mosquitos to humans: genetic evolution of zika virus.initially isolated in 1947, zika virus (zikv) has recently emerged as a significant public health concern. sequence analysis of all 41 known zikv rna open reading frames to date indicates that zikv has undergone significant changes in both protein and nucleotide sequences during the past half century.201627091703
emergency contraception in a public health emergency: exploring pharmacy availability in brazil.dedicated progestin-only emergency contraceptive pills (ecps) have been available with a prescription in brazil since 1999. however, utilization of emergency contraception has been limited. we conducted a mystery client study at retail pharmacies in three regions to assess current availability.201627091724
zika virus, emergencies, uncertainty and vulnerable populations. 201627092361
characterization of lethal zika virus infection in ag129 mice.mosquito-borne zika virus (zikv) typically causes a mild and self-limiting illness known as zika fever, which often is accompanied by maculopapular rash, headache, and myalgia. during the current outbreak in south america, zikv infection during pregnancy has been hypothesized to cause microcephaly and other diseases. the detection of zikv in fetal brain tissue supports this hypothesis. because human infections with zikv historically have remained sporadic and, until recently, have been limited t ...201627093158
structure of the thermally stable zika virus.zika virus (zikv), formerly a neglected pathogen, has recently been associated with microcephaly in fetuses, and with guillian-barré syndrome in adults. here we present the 3.7 å resolution cryo-electron microscopy structure of zikv, and show that the overall architecture of the virus is similar to that of other flaviviruses. sequence and structural comparisons of the zikv envelope (e) protein with other flaviviruses show that parts of the e protein closely resemble the neurovirulent west nile a ...201627093288
public health authorities race to contain fast-moving zika outbreak.with the zika virus disease spreading rapidly through latin america, public health authorities in the united states are racing to contain the outbreak. by the end of february, the cdc had confirmed 147 zika cases in u.s. residents who had traveled to zika-endemic areas. while symptoms of zika tend to be mild, the virus has been linked to serious birth defects, so public health efforts are focused primarily at mitigating the risk zika poses to pregnant women. by mid-february, nine pregnant women ...201627093766
the global spread of zika virus: is public and media concern justified in regions currently unaffected?zika virus, an aedes mosquito-borne flavivirus, is fast becoming a worldwide public health concern following its suspected association with over 4000 recent cases of microcephaly among newborn infants in brazil.201627093860
zika virus and maxillofacial surgery. 201627094497
zika virus: what nurses need to know. 201627096910
knowledge regarding zika virus infection among dental practitioners of tricity area (chandigarh, panchkula and mohali), india.zika virus (zikv), a vector-borne virus affecting a large number of people, has today become a major public health concern in the developed and developing countries worldwide.201627098947
the mitotic spindle: linking teratogenic effects of zika virus with human genetics?recently, an association between zika virus infection and microcephaly/ocular findings was found to be reasonable e.g. because of the demonstration that the virus was found in the brain of a fetus after presumed maternal infection. although there is no proof yet for a causal relationship, for an appropriate risk calculation efforts are urgently needed to either establish or disprove this assumption.201627099632
the tree(s) of life: the human placenta and my journey to learn more about it. 201627100178
solvent/detergent virally inactivated serum eye drops restore healthy ocular epithelium in a rabbit model of dry-eye syndrome.application of autologous serum eye drops (seds) is a recognized means to treat severe dry-eye syndrome (des). due to the inconvenience and difficulty of preparing seds from some patients, producing seds from allogeneic blood donations is gaining popularity. a major safety concern associated with allogeneic blood is virus transmission. we therefore herein evaluated the possibility of applying a solvent/detergent (s/d) treatment to inactivate viruses and studied the impacts of such treatment of s ...201627100624
zika virus-related news coverage and online behavior, united states, guatemala, and brazil. 201627100826
patterns in zika virus testing and infection, by report of symptoms and pregnancy status - united states, january 3-march 5, 2016.cdc recommends zika virus testing for potentially exposed persons with signs or symptoms consistent with zika virus disease, and recommends that health care providers offer testing to asymptomatic pregnant women within 12 weeks of exposure. during january 3-march 5, 2016, zika virus testing was performed for 4,534 persons who traveled to or moved from areas with active zika virus transmission; 3,335 (73.6%) were pregnant women. among persons who received testing, 1,541 (34.0%) reported at least ...201627101541
an updated checklist of mosquito species (diptera: culicidae) from madagascar.an updated checklist of 235 mosquito species from madagascar is presented. the number of species has increased considerably compared to previous checklists, particularly the last published in 2003 (178 species). this annotated checklist provides concise information on endemism, taxonomic position, developmental stages, larval habitats, distribution, behavior, and vector-borne diseases potentially transmitted. the 235 species belong to 14 genera: aedeomyia (3 species), aedes (35 species), anophel ...201627101839
zika virus infection during pregnancy and microcephaly occurrence: a review of literature and brazilian data.in november of 2015, the ministry of health of brazil published an announcement confirming the relationship between zika virus and the microcephaly outbreak in the northeast, suggesting that infected pregnant women might have transmitted the virus to their fetuses. the objectives of this study were to conduct a literature review about zika virus infection and microcephaly, evaluate national and international epidemiological data, as well as the current recommendations for the health teams. zika ...201727102780
rumor has it; the truth behind zika virus. 201727102926
positive igm for zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in brazil. 201627103126
zika virus and hyperglycaemia in pregnancy. 201627103128
complete genome sequence of zika virus from the first imported case in mainland china.the first case of zika virus infection was identified in a chinese traveler returning from venezuela in february 2016. this report describes the complete genome sequence of zika virus from the first imported case in china. the genome sequence analysis showed that the zika virus isolated in this case belongs to the asian lineage.201627103718
assessing the potential risk of zika virus epidemics in temperate areas with established aedes albopictus populations.based on 2015 abundance of aedes albopictus in nine northern italian municipalities with temperate continental/oceanic climate, we estimated the basic reproductive number r0 for zika virus (zikv) to be systematically below the epidemic threshold in most scenarios. results were sensitive to the value of the probability of mosquito infection after biting a viraemic host. therefore, further studies are required to improve models and predictions, namely evaluating vector competence and potential non ...201627104366
isolation and characterization of zika virus imported to china using c6/36 mosquito cells. 201627105638
zika virus and microcephaly: challenges for a long-term agenda.since its introduction in brazil in 2015, zika virus (zikv) has begun to spread worldwide. one of the major infection outcomes is related to congenital malformations, but little is known about the pathogenicity of zikv. here we discuss concerns about the ongoing zikv epidemic in the context of academic research, politics, and society.201627105931
zika virus outbreak in haiti in 2014: molecular and clinical data.zika virus (zikv), first isolated in uganda in 1947, is currently spreading rapidly through south america and the caribbean. in brazil, infection has been linked with microcephaly and other serious complications, leading to declaration of a public health emergency of international concern; however, there currently are only limited data on the virus (and its possible sources and manifestations) in the caribbean.201627111294
the paradigm of the paradox: women, pregnant women, and the unequal burdens of the zika virus pandemic. 201627111356
zika virus could infect up to four million, who predicts. 201627111968
top 10 facts you need to know about zika virus. 201627111981
zika virus: a global threat to humanity: a comprehensive review and current developments.at present, one of greatest concerns of medical personnel is zika virus (zikv). though it has been reported for quite a long time, its rapid emergence, new modes of transmission, and more importantly, the congenital anomalies associated with it have made the situation worse. it was first detected in 1947. after that, this infection was found in the countries of africa as well as asia. at present, interestingly it has been reported from brazil. microcephaly and intracranial calcification have bee ...027114968
exposure of a dengue vector to tea and its waste: survival, developmental consequences, and significance for pest management.dengue mosquitoes are evolving into a broader global public health menace, with relentless outbreaks and the rise in number of zika virus disease cases as reminders of the continued hazard associated with aedes vectors. the use of chemical insecticides-the principal strategy against mosquito vectors-has been greatly impeded due to the development of insecticide resistance and the shrinking spectrum of effective agents. therefore, there is a pressing need for new chemistries for vector control. t ...201627115536
spread of the invasive mosquitoes aedes aegypti and aedes albopictus in the black sea region increases risk of chikungunya, dengue, and zika outbreaks in europe. 201627115737
guillain-barré syndrome associated with zika virus infection. 201627115821
brain-region-specific organoids using mini-bioreactors for modeling zikv exposure.cerebral organoids, three-dimensional cultures that model organogenesis, provide a new platform to investigate human brain development. high cost, variability, and tissue heterogeneity limit their broad applications. here, we developed a miniaturized spinning bioreactor (spinω) to generate forebrain-specific organoids from human ipscs. these organoids recapitulate key features of human cortical development, including progenitor zone organization, neurogenesis, gene expression, and, notably, a di ...201627118425
zika virus-associated guillain-barré syndrome: a warning for critical care physicians. 201627118575
studies using ips cells support a possible link between zika and microcephaly.there is a suspected link between brazilian babies born with microcephaly and zika virus (zikv) infection. however, little is know about the brain cell targets and the mechanisms that zika virus may cause microcephaly. a recent report demonstrated that zika virus infection increases cell death and dysregulates cell-cycle, resulting in attenuated human neural progenitor cells growth. this study fills a major gap and serves as an entry point to establish a mechanistic link between zika infection a ...201627119012
[suspected zika virus infection: who should be tested?]. 201627119856
phylogenetic analyses of chikungunya virus among travelers in rio de janeiro, brazil, 2014-2015.chikungunya virus (chikv) is a mosquito-borne pathogen that emerged in brazil by late 2014. in the country, two chikv foci characterized by the east/central/south africa and asian genotypes, were established in north and northeast regions. we characterized, by phylogenetic analyses of full and partial genomes, chikv from rio de janeiro state (2014-2015). these chikv strains belong to the asian genotype, which is the determinant of the current northern brazilian focus, even though the genome sequ ...201627120007
zika virus detection in cerebrospinal fluid from two patients with encephalopathy, martinique, february 2016.we report two cases of encephalopathy (one with seizures, one with electroencephalogram changes) in patients with zika virus infection. the cases occurred on martinique in february 2016, during the zika virus outbreak. awareness of the various neurological complications of zika virus infection is needed for patients living in areas affected by zika virus infections or for travellers to these areas.201627123558
structure and ligand-binding mechanism of a cysteinyl leukotriene-binding protein from a blood-feeding disease vector.blood-feeding disease vectors mitigate the negative effects of hemostasis and inflammation through the binding of small-molecule agonists of these processes by salivary proteins. in this study, a lipocalin protein family member (ltbp1) from the saliva of rhodnius prolixus, a vector of the pathogen trypanosoma cruzi, is shown to sequester cysteinyl leukotrienes during feeding to inhibit immediate inflammatory responses. calorimetric binding experiments showed that ltbp1 binds leukotrienes c4 (ltc ...201627124118
zika virus: an update on epidemiology, pathology, molecular biology, and animal model.zika virus (zikv) was first described in 1947, and became a health emergency problem in 2016 when its association with fetal microcephaly cases was confirmed by centers for disease control and prevention (cdc) in the united states. to date, zikv infection has been documented in 66 countries. zikv is recognized as a neurotropic virus and numerous diseases manifested in multiple neurological disorders have been described, mainly in countries that have been exposed to zikv after the 2007 outbreak i ...201627124623
the wmel strain of wolbachia reduces transmission of chikungunya virus in aedes aegypti.new approaches to preventing chikungunya virus (chikv) are needed because current methods are limited to controlling mosquito populations, and they have not prevented the invasion of this virus into new locales, nor have they been sufficient to control the virus upon arrival. a promising candidate for arbovirus control and prevention relies on the introduction of the intracellular bacterium wolbachia into aedes aegypti mosquitoes. this primarily has been proposed as a tool to control dengue viru ...201627124663
high specificity of a novel zika virus elisa in european patients after exposure to different flaviviruses.the current zika virus (zikv) epidemic in the americas caused an increase in diagnostic requests in european countries. here we demonstrate high specificity of the euroimmun anti-zikv igg and igm elisa tests using putative cross-reacting sera of european patients with antibodies against tick-borne encephalitis virus, dengue virus, yellow fever virus and hepatitis c virus. this test may aid in counselling european travellers returning from regions where zikv is endemic.201627126052
predicting dengue fever outbreaks in french guiana using climate indicators.dengue fever epidemic dynamics are driven by complex interactions between hosts, vectors and viruses. associations between climate and dengue have been studied around the world, but the results have shown that the impact of the climate can vary widely from one study site to another. in french guiana, climate-based models are not available to assist in developing an early warning system. this study aims to evaluate the potential of using oceanic and atmospheric conditions to help predict dengue f ...201627128312
confirmed zika virus infection in a belgian traveler returning from guatemala, and the diagnostic challenges of imported cases into europe.we report the first laboratory-confirmed zika virus (zikv) infection in a belgian traveler after a three week holiday in guatemala, december 2015. this case along with other imported cases into europe emphases once again the need for accurate diagnostic tools for this rapidly emerging virus. the challenge is to diagnose patients in the acute phase, which appears short, as serological testing is complicated by cross-reactivity, vaccination status and scarce availability of specific zikv tests.201627128355
the risk of dengue for non-immune foreign visitors to the 2016 summer olympic games in rio de janeiro, brazil.rio de janeiro in brazil will host the summer olympic games in 2016. about 400,000 non-immune foreign tourists are expected to attend the games. as brazil is the country with the highest number of dengue cases worldwide, concern about the risk of dengue for travelers is justified.201627129407
zika virus and zika fever.an emerging mosquito-borne arbovirus named zika virus (zikv), of the family flaviviridae and genus flavivirus, is becoming a global health threat. zikv infection was long neglected due to its sporadic nature and mild symptoms. however, recently, with its rapid spread from asia to the americas, affecting more than 30 countries, accumulating evidences have demonstrated a close association between infant microcephaly and zika infection in pregnant women. here, we reviewed the virological, epidemiol ...201627129450
phylogenetic analysis revealed the central roles of two african countries in the evolution and worldwide spread of zika virus.recent outbreaks of zika virus (zikv) infections in oceania's islands and the americas were characterized by high numbers of cases and the spread of the virus to new areas. to better understand the origin of zikv, its epidemic history was reviewed. although the available records and information are limited, two major genetic lineages of zikv were identified in previous studies. however, in this study, three lineages were identified based on a phylogenetic analysis of all virus sequences from gen ...201627129451
dengue virus immunopathogenesis: lessons applicable to the emergence of zika virus.dengue is the leading mosquito-transmitted viral infection in the world. there are more than 390 million new infections annually; while the majority of infected individuals are asymptomatic or develop a self-limited dengue fever, up to 1 million clinical cases develop severe manifestations, including dengue hemorrhagic fever and shock syndrome, resulting in ~25,000 deaths annually, mainly in children. gaps in our understanding of the mechanisms that contribute to dengue infection and immunopatho ...201627130436
dtb select: 5 | may 2016.hyperkalaemia with spironolactone ● testosterone treatment in older men and sexual function ● otc artificial tear drops for dry eye ● decline in age-specific incidence of dementia ● diabetes and blood pressure targets ● zika virus and travel advice for pregnant women ● minimising the risk of dka with sglt2 inhibitors ● nsaids for chronic low back pain ● review of online point-of-care information.201627130673
open drug discovery for the zika virus.the zika virus (zikv) outbreak in the americas has caused global concern that we may be on the brink of a healthcare crisis. the lack of research on zikv in the over 60 years that we have known about it has left us with little in the way of starting points for drug discovery. our response can build on previous efforts with virus outbreaks and lean heavily on work done on other flaviviruses such as dengue virus. we provide some suggestions of what might be possible and propose an open drug discov ...201627134728
mapping zika virus infection using geographical information systems in tolima, colombia, 2015-2016.geographical information systems (gis) have been extensively used for the development of epidemiological maps of tropical diseases, however not yet specifically for zika virus (zikv) infection.201627134732
zika virus infections imported from brazil to portugal, 2015.zika virus is an emerging arbovirus transmitted by aedes sp. mosquitoes like the dengue and chikungunya viruses. zika virus was until recently considered a mild pathogenic mosquito-borne flavivirus with very few reported benign human infections. in 2007, an epidemic in micronesia initiated the turnover in the epidemiological history of zika virus and more recently, the potential association with congenital microcephaly cases in brazil 2015, still under investigation, led the world health organiz ...201627134823
the emergence of zika virus: a narrative review.zika virus (zikv) is yet another arbovirus that is rapidly emerging on a global scale, on the heels of a chikungunya epidemic in the americas that began in 2013. a zikv epidemic that began in brazil in 2015 has now spread rapidly to more than 30 countries in the americas and the caribbean, infecting more than 2 million inhabitants. this epidemic currently continues unabated. the explosive nature of recent outbreaks and concerning links to guillain-barré syndrome and microcephaly are incompletely ...201627135717
potential impact of sexual transmission on ebola virus epidemiology: sierra leone as a case study.sexual transmission of ebola virus disease (evd) 6 months after onset of symptoms has been recently documented, and ebola virus rna has been detected in semen of survivors up to 9 months after onset of symptoms. as countries affected by the 2013-2015 epidemic in west africa, by far the largest to date, are declared free of ebola virus disease (evd), it remains unclear what threat is posed by rare sexual transmission events that could arise from survivors.201627135922
[zika virus, an emerging threat].zika virus, discovered in 1947, is particularly publicized because of its involvement in a major epidemic that began in 2015 and which epicenter is located in latin america, mainly in brazil. in the majority of cases (70-80 %) the infection is asymptomatic, however in some patients, moderate fever, skin rash, conjunctivitis and myalgia may occur. more alarming, neurological complications are reported, in particular cases of microcephaly probably resulting from the infection of women in the first ...201627137695
neonatal neuroradiological aspects in zika virus infection. 201627138556
febrile or exanthematous illness associated with zika, dengue, and chikungunya viruses, panama. 201627139219
the development of small animal models for zika virus vaccine efficacy testing and pathological assessment. 201627139439
zika virus disease in travelers returning to the united states, 2010-2014.zika virus is an emerging mosquito-borne flavivirus that typically causes a mild febrile illness with rash, arthralgia, or conjunctivitis. zika virus has recently caused large outbreaks of disease in southeast asia, pacific ocean islands, and the americas. we identified all positive zika virus test results performed at u.s. centers for disease control and prevention from 2010 to 2014. for persons with test results indicating a recent infection with zika virus, we collected information on demogra ...201627139440
epidemiology: which regions are vulnerable to zika virus? 201627140691
zika virus study in the bmj was different from the one reported in the new england journal of medicine. 201627142055
[clinical analysis of two cases of imported children zika virus infection in china].to analyze the clinical characteristics, outcome and diagnosis of two cases of imported children zika virus infection in china.201627143081
overview of zika virus (zikv) infection in regards to the brazilian epidemic.zika virus (zikv), a mosquito-borne flavivirus, belongs to the flaviviridae family, genus flavivirus. zikv was initially isolated in 1947 from a sentinel monkey in the zika forest, uganda. little clinical importance was attributed to zikv, once only few symptomatic cases were reported in some african and southeast asiatic countries. this situation changed in 2007, when a large outbreak was registered on the yap island, micronesia, caused by the asian zikv lineage. between 2013 and 2014, zikv spr ...201627143174
zika virus damages the human placental barrier and presents marked fetal neurotropism.an unusually high incidence of microcephaly in newborns has recently been observed in brazil. there is a temporal association between the increase in cases of microcephaly and the zika virus (zikv) epidemic. viral rna has been detected in amniotic fluid samples, placental tissues and newborn and fetal brain tissues. however, much remains to be determined concerning the association between zikv infection and fetal malformations. in this study, we provide evidence of the transplacental transmissio ...201627143490
time lags between exanthematous illness attributed to zika virus, guillain-barré syndrome, and microcephaly, salvador, brazil.zika virus infection emerged as a public health emergency after increasing evidence for its association with neurologic disorders and congenital malformations. in salvador, brazil, outbreaks of acute exanthematous illness (aei) attributed to zika virus, guillain-barré syndrome (gbs), and microcephaly occurred in 2015. we investigated temporal correlations and time lags between these outbreaks to identify a common link between them by using epidemic curves and time series cross-correlations. numb ...201627144515
vector competence of aedes aegypti and aedes polynesiensis populations from french polynesia for chikungunya virus.from october 2014 to march 2015, french polynesia experienced for the first time a chikungunya outbreak. two aedes mosquitoes may have contributed to chikungunya virus (chikv) transmission in french polynesia: the worldwide distributed ae. aegypti and the polynesian islands-endemic ae. polynesiensis mosquito.201627144888
multi-country survey revealed prevalent and novel f1534s mutation in voltage-gated sodium channel (vgsc) gene in aedes albopictus.aedes albopictus is an important dengue vector because of its aggressive biting behavior and rapid spread out of its native home range in southeast asia. pyrethroids are widely used for adult mosquito control, and resistance to pyrethroids should be carefully monitored because vector control is the only effective method currently available to prevent dengue transmission. the voltage-gated sodium channel gene is the target site of pyrethroids, and mutations in this gene cause knockdown resistance ...201627144981
public health round-up. 201627147758
zika virus: the latest newcomer.since the beginning of this century, humanity has been facing a new emerging, or re-emerging, virus threat almost every year: west nile, influenza a, avian flu, dengue, chikungunya, sars, mers, ebola, and now zika, the latest newcomer. zika virus (zikv), a flavivirus transmitted by aedes mosquitoes, was identified in 1947 in a sentinel monkey in uganda, and later on in humans in nigeria. the virus was mainly confined to the african continent until it was detected in south-east asia the 1980's, t ...201627148186
update: ongoing zika virus transmission - puerto rico, november 1, 2015-april 14, 2016.zika virus is a flavivirus transmitted primarily by aedes species mosquitoes, and symptoms of infection can include rash, fever, arthralgia, and conjunctivitis (1).* zika virus infection during pregnancy is a cause of microcephaly and other severe brain defects (2). infection has also been associated with guillain-barré syndrome (3). in december 2015, puerto rico became the first u.s. jurisdiction to report local transmission of zika virus, with the index patient reporting symptom onset on novem ...201627149205
a susceptible mouse model for zika virus infection.zika virus (zikv) is a mosquito-borne pathogen which has recently spread beyond africa and into pacific and south american regions. despite first being detected in 1947, very little information is known about the virus, and its spread has been associated with increases in guillain-barre syndrome and microcephaly. there are currently no known vaccines or antivirals against zikv infection. progress in assessing interventions will require the development of animal models to test efficacies; however ...201627149521
exploiting genetic interference for antiviral therapy.rapidly evolving viruses are a major threat to human health. such viruses are often highly pathogenic (e.g., influenza virus, hiv, ebola virus) and routinely circumvent therapeutic intervention through mutational escape. error-prone genome replication generates heterogeneous viral populations that rapidly adapt to new selection pressures, leading to resistance that emerges with treatment. however, population heterogeneity bears a cost: when multiple viral variants replicate within a cell, they c ...201627149616
zika virus: a new animal model for an arbovirus. 201627149628
asymptomatic pregnant women returning to the united states from countries experiencing a zika virus outbreak should be tested for zika virus: against: not so fast. 201627149896
asymptomatic pregnant women returning to the united states from countries experiencing a zika virus outbreak should be tested for zika virus : for: importance of identification in all pregnant women. 201627150136
zika virus and pregnancy. 201627150456
neurodevelopmental disorders: risks of zika virus during the first trimester of pregnancy. 201627150532
microcephaly associated with maternal zika virus infection. 201627150580
zika virus and microcephaly - more questions than answers? 201627150736
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