Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| yeast oropharyngeal colonization in human immunodeficiency virus-infected patients in central taiwan. | a prospective, cross-sectional study was conducted at a medical center in central taiwan to understand the prevalence, associated factors, and microbiologic features for oropharyngeal yeast colonization in human immunodeficiency virus-infected outpatients. oral yeast colonization was detected in 127 (45 %) patients, including 21 (16.5 %) colonized by more than one species. of the 154 isolates, candida albicans was the most common species (114, 74 %), followed by candida dubliniensis (10, 6.5 %), ... | 2014 | 24804977 |
| post-antifungal effect and adhesion to buccal epithelial cells of oral candida dubliniensis isolates subsequent to limited exposure to amphotericin b, ketoconazole and fluconazole. | the post-antifungal effect (pafe) of candida and its adherence to oral mucosal surfaces are important determinants of candidal pathogenicity. candida dubliniensis is allied with recurrent oral candidosis. oral candidosis can be treated with amphotericin b, ketoconazole and fluconazole. there is no information on the pafe and its impact on adhesion to oral buccal epithelial cells (bec) of oral c. dubliniensis isolates. therefore, the main objective was to reconnoiter the pafe and adhesion to bec ... | 2015 | 24850753 |
| rare case of exogenous candida dubliniensis endophthalmitis: a case report and brief review of the literature. | candida dubliniensis is a recently described opportunistic fungal pathogen that rarely infects the eye. reported cases of c. dubliniensis endophthalmitis have been of endogenous etiology and demonstrated recovery of visual acuity with timely treatment. we herein report an unusual case of severe c. dubliniensis endophthalmitis requiring enucleation. | 2014 | 24860628 |
| phylogenetic and syntenic analyses of the 12-spanner drug:h(+) antiporter family 1 (dha1) in pathogenic candida species: evolution of mdr1 and flu1 genes. | candida albicans and other pathogenic candida species can develop resistance to clinical fungicides through active drug export mediated by multidrug efflux pumps, in particular by members of the drug:h(+) antiporter family 1 (dha1). the dha1 proteins encoded in the genomes of 31 hemiascomycetous strains from 25 species were identified and homology relationships between these proteins and the functionally characterised dha1 in the model yeast saccharomyces cerevisiae were established. gene neighb ... | 2014 | 24907457 |
| uncommon opportunistic yeast bloodstream infections from qatar. | eleven uncommon yeast species that are associated with high mortality rates irrespective of antifungal therapy were isolated from 17/187 (201 episodes) pediatric and elderly patients with fungemia from qatar. the samples were taken over a 6-year period (january 2004-december 2010). isolated species included kluyveromyces marxianus, lodderomyces elongisporus, lindnera fabianii, candida dubliniensis, meyerozyma guilliermondii, candida intermedia, pichia kudriavzevii, yarrowia lipolytica, clavispor ... | 2014 | 24934803 |
| isavuconazole and nine comparator antifungal susceptibility profiles for common and uncommon candida species collected in 2012: application of new clsi clinical breakpoints and epidemiological cutoff values. | the in vitro activity of isavuconazole and nine antifungal comparator agents was assessed using reference broth microdilution methods against 1,421 common and uncommon species of candida from a 2012 global survey. isolates were identified using chromagar, biochemical methods and sequencing of its and/or 28s regions. candida spp. were classified as either susceptible or resistant and as wild type (wt) or non-wt using clsi clinical breakpoints or epidemiological cutoff values, respectively, for th ... | 2014 | 24952015 |
| oral microbial colonization in children with sickle cell anaemia under long-term prophylaxis with penicillin. | sickle cell anaemia (sca) is the most frequent haematological hereditary disease. children with sca are submitted to long-term prophylactic therapy with penicillin, but little is known about its impact on oral microflora. the aim of this study was to evaluate the oral microbial colonization of paediatric patients with sca. | 2014 | 24967510 |
| prevalence of candida albicans-closely related yeasts, candida africana and candida dubliniensis, in vulvovaginal candidiasis. | isolates of candida africana and c. dubliniensis were recovered from patients with vulvovaginal candidiasis (vvc). the isolates were initially identified as c. albicans through use of the api candida system. we retrospectively reexamined 1014 vaginal isolates presumptively determined to be c. albicans at the department of obstetrics and gynecology of peking university shenzhen hospital from 1 january 2003 through 31 december 2012. our objective was to determine, via detection of the hwp1 gene, i ... | 2014 | 25023482 |
| [candida dubliniensis in clinical specimens and possibilities for identification]. | the species candida dubliniensis shares a wide range of phenotypic characteristics with candida albicans, the most common yeast species isolated from clinical specimens. this is a considerable complication for the detection and identification of candida dubliniensis from clinical specimens. the lack of data on the incidence of c. dubliniensis in the czech republic was the motivation behind the efforts to detect this pathogen in specimens analyzed at the institute for microbiology, faculty of med ... | 2014 | 25025678 |
| activity of echinocandins and triazoles against a contemporary (2012) worldwide collection of yeast and moulds collected from invasive infections. | in this study, 1717 fungal clinical isolates causing invasive fungal infections were evaluated against nine antifungal agents using clinical and laboratory standards institute (clsi) reference broth microdilution methods. the isolates comprised 1487 candida spp., 109 aspergillus spp., 86 non-candida yeasts (including 52 isolates of cryptococcus neoformans) and 35 rare moulds obtained during 2012 from 72 hospitals worldwide. echinocandin resistance among candida spp. was low, and resistance rates ... | 2014 | 25129315 |
| oral administration of the broad-spectrum antibiofilm compound toremifene inhibits candida albicans and staphylococcus aureus biofilm formation in vivo. | we here report on the in vitro activity of toremifene to inhibit biofilm formation of different fungal and bacterial pathogens, including candida albicans, candida glabrata, candida dubliniensis, candida krusei, pseudomonas aeruginosa, staphylococcus aureus, and staphylococcus epidermidis. we validated the in vivo efficacy of orally administered toremifene against c. albicans and s. aureus biofilm formation in a rat subcutaneous catheter model. combined, our results demonstrate the potential of ... | 2014 | 25288093 |
| investigation of minor species candida africana, candida stellatoidea and candida dubliniensis in the candida albicans complex among yaoundé (cameroon) hiv-infected patients. | minor species of the candida albicans complex may cause overestimation of the epidemiology of c. albicans, and misidentifications could mask their implication in human pathology. authors determined the occurrence of minor species of the c. albicans complex (c. africana, c. dubliniensis and c. stellatoidea) among yaoundé hiv-infected patients, cameroon. stool, vaginal discharge, urine and oropharyngeal samples were analysed by mycological diagnosis. isolates were identified by conventional method ... | 2015 | 25289589 |
| impact of brief and sequential exposure to nystatin, amphotericin b, ketoconazole, and fluconazole in modulating adhesion traits of oral candida dubliniensis isolates. | candida adherence is implicated in the pathogenesis of oral candidosis. adhesion to buccal epithelial cells (bec), germ tube (gt) formation, and relative cell surface hydrophobicity (csh) are colonization attributes of candidal pathogenicity. candida dubliniensis (c. dubliniensis) is allied with recurrent oral candidosis, which can be treated with nystatin, amphotericin b, ketoconazole, and fluconazole. due to the diluent effect of saliva and the cleansing effect of the oral musculature in the o ... | 2016 | 25388637 |
| oral candida carriage, quantification, and species characterization in oral submucous fibrosis patients and healthy individuals. | to determine the prevalence of oral candida carriage, candidal quantification, and various subtypes of candida species in oral submucous fibrosis patients and healthy individuals. | 2011 | 25426899 |
| [evaluation of mass spectrometry for the identification of clinically interesting yeasts]. | identification of yeasts is based on morphological, biochemical and nutritional characteristics, and using molecular methods. matrix-assisted laser desorption/ionization time-of-flight (maldi-tof) mass spectrometry, a new method for the identification of microorganisms, has demonstrated to be very useful. the aim of this study is to evaluate this new method in the identification of yeasts. | 2017 | 25444360 |
| in vitro adhesion of oral candida dubliniensis isolates to acrylic denture surfaces following brief exposure to sub-cidal concentrations of polyenes, azoles and chlorhexidine. | we aimed to investigate the effect of brief exposure to sub-cidal concentrations of nystatin, amphotericin b, ketoconazole, fluconazole and chlorhexidine gluconate on the adhesion of oral candida dubliniensis isolates to the surface of acrylic dentures. | 2015 | 25471106 |
| identification and characterization of nine atypical candida dubliniensis clinical isolates. | candida dubliniensis is a pathogenic yeast of the genus candida closely related to candida albicans. the phenotypic similarity of these two species often leads to misidentification of c. dubliniensis isolates in clinical samples. dna-based methods continue to be the most effective means of discriminating accurately between the two species. here, we report on the identification of nine unusual candida isolates that showed ambiguous identification patterns on the basis of their phenotypic and immu ... | 2015 | 25480879 |
| [yeast species in vulvovaginitis candidosa]. | vulvovaginal candidiasis is the most common mycosis, however, the available information about antifungal susceptibilities of these yeasts is limited. | 2015 | 25544052 |
| chemical composition and antimicrobial evaluation of the essential oils of bocageopsis pleiosperma maas. | essential oils from the leaves, twigs and barks of bocageopsis pleiosperma maas were obtained by using hydrodistillation and analysed by using gas chromatography coupled to mass spectrometry. several compounds (51) were detected and identified, being β-bisabolene the main component in all aerial parts of the plant, with higher concentration in the leaves (55.77%), followed by barks (38.53%) and twigs (34.37%). in order to increase the biological knowledge about the essential oil of bocageopsis s ... | 2015 | 25562370 |
| candida dubliniensis and candida albicans differentiation by colony morphotype in sabouraud-triphenyltetrazolium agar. | candida dubliniensis is a germ tube and chlamydoconidia producing candida species that may be misidentified as candida albicans. molecular-based methods are the most reliable techniques for c. albicans and c. dubliniensis differentiation. however, accurate, quick and inexpensive phenotypic tests are needed to be used in low-complexity mycology laboratories. | 2015 | 25613786 |
| fungal mediator tail subunits contain classical transcriptional activation domains. | classical activation domains within dna-bound eukaryotic transcription factors make weak interactions with coactivator complexes, such as mediator, to stimulate transcription. how these interactions stimulate transcription, however, is unknown. the activation of reporter genes by artificial fusion of mediator subunits to dna binding domains that bind to their promoters has been cited as evidence that the primary role of activators is simply to recruit mediator. we have identified potent classica ... | 2015 | 25645928 |
| [endogenous candida dubliniensis endophtalmitis. first case in mexico]. | candida endophthalmitis is related to immunosuppression state, intravenous catheters, invasive procedures and parenteral feeding. it is estimated that between 2% and 10% of endophthalmitis are endogenous, within fungal etiology the most frequently isolated microorganism is candida albicans. the infection by c. dubliniensis is reported in less than 2 % of the cases of infection by candida at systemic level and few reported cases of endophthalmitis. the clinical presentation is poor vision , vitri ... | 2017 | 25680648 |
| comparison of the in vitro activity of echinocandins against candida albicans, candida dubliniensis, and candida africana by time-kill curves. | candida albicans remains the most common fungal pathogen. this species is closely related to 2 phenotypically similar cryptic species, candida dubliniensis and candida africana. this study aims to compare the antifungal activities of echinocandins against 7 c. albicans, 5 c. dubliniensis, and 2 c. africana strains by time-kill methodology. mic values were similar for the 3 species; however, differences in killing activity were observed among species, isolates, and echinocandins. echinocandins pr ... | 2015 | 25703894 |
| hematogenous dissemination of candida dubliniensis causing spondylodiscitis and spinal abscess in a hiv-1 and hcv-coinfected patient. | we report a case of spondylodiscitis and spinal abscess following haematogenous dissemination of the emerging yeast candida dubliniensis in a human immunodeficiency virus-1 (hiv-1) and hepatitis c virus (hcv)-coinfected patient. although c. dubliniensis is considered less virulent compared to its closest known relative candida albicans, reports of severe fungal infections are increasing. this case indicates that the pathogenicity of c. dubliniensis may be higher than previously believed. therefo ... | 2015 | 25750857 |
| first-time isolation of candida dubliniensis from plaque and carious dentine of primary teeth. | to determine those organisms of the genus candida associated with dental caries by investigating samples from active carious lesions. within the genus candida, the species candida albicans and candida dubliniensis are capable of forming chlamydospores and germ tubes. until it became possible in 1995 to differentiate between the two species taxonomically, c. dubliniensis was falsely identified as c. albicans. whilst the importance of c. albicans for rapidly progressing early childhood caries (ecc ... | 2015 | 25800500 |
| discrimination of candida albicans from candida dubliniensis by use of the biofire filmarray blood culture identification panel. | 2015 | 25878337 | |
| antifungal susceptibilities of candida, cryptococcus neoformans and aspergillus fumigatus from the asia and western pacific region: data from the sentry antifungal surveillance program (2010-2012). | the sentry antifungal surveillance program monitors global susceptibility rates of newer and established antifungal agents. we report the in vitro activity of seven antifungal agents against 496 contemporary clinical isolates of yeasts and molds. the isolates were obtained from 20 laboratories in the asia-western pacific (apac) region during 2010 through 2012. anidulafungin, caspofungin, micafungin, fluconazole, itraconazole, posaconazole and voriconazole were susceptibility tested using clsi me ... | 2015 | 25899126 |
| candida survival strategies. | only few candida species, e.g., candida albicans, candida glabrata, candida dubliniensis, and candida parapsilosis, are successful colonizers of a human host. under certain circumstances these species can cause infections ranging from superficial to life-threatening disseminated candidiasis. the success of c. albicans, the most prevalent and best studied candida species, as both commensal and human pathogen depends on its genetic, biochemical, and morphological flexibility which facilitates adap ... | 2015 | 25911234 |
| csr1/zap1 maintains zinc homeostasis and influences virulence in candida dubliniensis but is not coupled to morphogenesis. | the supply and intracellular homeostasis of trace metals are essential for every living organism. therefore, the struggle for micronutrients between a pathogen and its host is an important determinant in the infection process. in this work, we focus on the acquisition of zinc by candida dubliniensis, an emerging pathogen closely related to candida albicans. we show that the transcription factor csr1 is essential for c. dubliniensis to regulate zinc uptake mechanisms under zinc limitation: it gov ... | 2015 | 26002718 |
| impact of short-term exposure of antifungal agents on hemolysin activity of oral candida dubliniensis isolates from kuwait and sri lanka. | ability to produce hemolysin by candida species is an important determinant of its pathogenicity. candida dubliniensis is implicated in the causation of oral candidosis, which can be treated with polyene, echinocandin, and azole groups of antifungal agents as well as chlorhexidine. after oral application, however, the concentrations of these agents tend to decrease quickly to subtherapeutic levels due to the peculiarity of the oral environment. in this study, we have evaluated the effect of shor ... | 2016 | 26059506 |
| phenotypic detection of genitourinary candidiasis among sexually transmitted disease clinic attendees in ladoke akintola university teaching hospital, osogbo, nigeria. | the management of genitourinary candidiasis (gc) is fraught with challenges, especially, in an era of increasing antifungal resistance. this descriptive cross-sectional study conducted between may 2013 and january 2014 determined the prevalence and characteristics of gc and the species of candida among 369 attendees of a sexually transmitted disease (std) clinic of ladoke akintola university teaching hospital, osogbo, nigeria. appropriate urogenital specimen collected from each attendee was exam ... | 2015 | 26064140 |
| [evaluation of common commercial systems for the identification of yeast isolates in microbiology laboratories: a multicenter study]. | accurate and rapid identification of yeast isolates have become important in recent years for not only antifungal susceptibility testing due to the species-specific clinical resistance breakpoints but also early initiation of appropriate antifungal therapy. in clinical microbiology laboratories species identification of yeasts is often performed with several commercial systems based on biochemical properties and rarely according to the physiological and morphological characteristics. the aim of ... | 2015 | 26167821 |
| postantifungal effect of micafungin against the species complexes of candida albicans and candida parapsilosis. | micafungin is an effective antifungal agent useful for the therapy of invasive candidiasis. candida albicans is the most common cause of invasive candidiasis; however, infections due to non-c. albicans species, such as candida parapsilosis, are rising. killing and postantifungal effects (pafe) are important factors in both dose interval choice and infection outcome. the aim of this study was to determinate the micafungin pafe against 7 c. albicans strains, 5 candida dubliniensis, 2 candida afric ... | 2015 | 26168269 |
| in vitro postantifungal effect, adhesion traits and haemolysin production of candida dubliniensis isolates following exposure to 5-fluorocytosine. | the phenomenon of postantifungal effect (pafe), which is the suppression of candidal growth following brief exposure to antifungal agents, is linked with candidal pathogenicity. adhesion to buccal epithelial cells (bec), germ tube (gt) formation and relative cell surface hydrophobicity (csh) are all adhesion traits of candidal pathogenicity. ability to produce haemolysin by candida species is also a determinant of its pathogenicity. there is no information on either the pafe or its impact on adh ... | 2015 | 26201447 |
| mechanisms involved in the inhibition of glycolysis by cyanide and antimycin a in candida albicans and its reversal by hydrogen peroxide. a common feature in candida species. | in candida albicans, cyanide and antimycin a inhibited k(+) transport, not only with ethanol-o2 as the substrate, but also with glucose. the reason for this was that they inhibited not only respiration, but also fermentation, decreasing atp production. measurements of oxygen levels in cell suspensions allowed identification of the electron pathways involved. nadh fluorescence levels increased in the presence of the inhibitors, indirectly indicating lower levels of nad(+) and so pointing to glyce ... | 2015 | 26363023 |
| interferon-gamma immunotherapy in a patient with refractory disseminated candidiasis. | despite advances in supportive care and novel antifungal agents, mortality caused by invasive candida infection is high. a 3-year-old boy with disseminated candida dubliniensis infection during induction chemotherapy for acute lymphoblastic leukemia deteriorated despite resolution of neutropenia and appropriate antifungal treatment. monocyte human leukocyte antigen-dr expression was extremely low, suggesting immunoparalysis. adjuvant immunotherapy with interferon-gamma restored the immune respon ... | 2015 | 26379166 |
| comparison of switching and biofilm formation between mtl-homozygous strains of candida albicans and candida dubliniensis. | candida albicans and candida dubliniensis are highly related species that share the same main developmental programs. in c. albicans, it has been demonstrated that the biofilms formed by strains heterozygous and homozygous at the mating type locus (mtl) differ functionally, but studies rarely identify the mtl configuration. this becomes a particular problem in studies of c. dubliniensis, given that one-third of natural strains are mtl homozygous. for that reason, we have analyzed mtl-homozygous ... | 2015 | 26432632 |
| characterising atypical candida albicans clinical isolates from six third-level hospitals in bogotá, colombia. | candida species are the most frequently found fungal pathogens causing nosocomial disease in a hospital setting. such species must be correctly identified to ensure that appropriate control measures are taken and that suitable treatment is given for each species. candida albicans is causing most fungal disease burden worldwide; the challenge lies in differentiating it from emerging atypical, minor and related species such as candida dubliniensis and candida africana. the purpose of this study wa ... | 2015 | 26438104 |
| in vitro antimicrobial and antiproliferative activity of amphipterygium adstringens. | amphipterygium adstringens is a plant widely used in mexican traditional medicine for its known anti-inflammatory and antiulcer properties. in this work, we evaluated the in vitro antimicrobial and antiproliferative activities of the methanolic extract of a. adstringens against oral pathogens such as streptococcus mutans, porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, candida albicans, and candida dubliniensis, using microdilution (mic) and agar diffusion methods (mbc), and the ... | 2015 | 26451151 |
| chromatin immunoprecipitation (chip) assay in candida albicans. | chromatin immunoprecipitation (chip) is a widely used technique which can determine the in vivo association of a specific protein on a particular dna locus in the genome. in this method cross-linked chromatin is sheared and immunoprecipitated with antibodies raised against a target protein of interest. the end result of this process is the enrichment of dna fragments associated with the desired protein. thus, interactions between proteins and genomic loci in cellular context can be determined by ... | 2016 | 26519064 |
| elucidation of a key position for acyltransfer activity in candida parapsilosis lipase/acyltransferase (cplip2) and in pseudozyma antarctica lipase a (cal-a) by rational design. | performing transesterifications in aqueous media is becoming a priority challenge in lipid biotechnology in order to develop more eco-friendly and efficient biocatalytic processes in systems containing both polar and apolar substrates. in this context, our group has explored for several years the high potential of the lipase/acyltransferase cplip2 from candida parapsilosis and of several of its homologs, that catalyze efficiently acyltransfer reactions in lipid/water media with high water activi ... | 2016 | 26602447 |
| an in vitro study of antifungal drug susceptibility of candida species isolated from human immunodeficiency virus seropositive and human immunodeficiency virus seronegative individuals in lucknow population uttar pradesh. | candidiasis is the most common opportunistic infection in human immunodeficiency virus (hiv) seropositive patients, starting from asymptomatic colonization to pathogenic forms and gradual colonization of non-albicans in patients with advanced immunosuppression leads to resistance for azole group of antifungal drugs with high rate of morbidity and mortality. | 2017 | 26604498 |
| prevalence of candida albicans and candida dubliniensis in caries-free and caries-active children in relation to the oral microbiota-a clinical study. | the correlation between caries and the oral prevalence of candida spp. in children is contradictory in literature. thereby, authors focused on candida albicans as the most isolated candida species from the oral cavity. therefore, the aim of the present study was to compare caries-free and caries-bearing children regarding their oral carriage of candida spp. | 2016 | 26696116 |
| candida albicans exhibits enhanced alkaline and temperature induction of efg1-regulated transcripts relative to candida dubliniensis. | filamentous growth is an important virulence trait of the human pathogenic fungi within the genus candida, and the greater propensity of c. albicans to form hyphae has been proposed to account for the greater virulence of this species relative to the less pathogenic species c. dubliniensis. in this meta-analysis, we compare the transcriptional response of c. dubliniensis and c. albicans to the individual environmental stimuli that shape the gene expression profiles during filamentation in 10% se ... | 2015 | 26697354 |
| discovery of the gray phenotype and white-gray-opaque tristable phenotypic transitions in candida dubliniensis. | candida dubliniensis is closely related to candida albicans, a major causative agent of candidiasis, and is primarily associated with oral colonization and infection in human immunodeficiency virus (hiv)-positive patients. despite the high similarity of genomic and phenotypic features between the 2 species, c. dubliniensis is much less virulent and less prevalent than c. albicans. the ability to change morphological phenotypes is a striking feature of candida species and is linked to virulence. ... | 2016 | 26714067 |
| gray phenotype: enhanced fitness strategy for candida dubliniensis? | 2016 | 26786843 | |
| repeat-associated fission yeast-like regional centromeres in the ascomycetous budding yeast candida tropicalis. | the centromere, on which kinetochore proteins assemble, ensures precise chromosome segregation. centromeres are largely specified by the histone h3 variant cenp-a (also known as cse4 in yeasts). structurally, centromere dna sequences are highly diverse in nature. however, the evolutionary consequence of these structural diversities on de novo cenp-a chromatin formation remains elusive. here, we report the identification of centromeres, as the binding sites of four evolutionarily conserved kineto ... | 2016 | 26845548 |
| caspofungin-induced in-vitro post-antifungal effect and its impact on adhesion related traits of oral candida dubliniensis and candida albicans isolates. | adhesion to buccal epithelial cells (bec) and denture acrylic surfaces (das), germ tube (gt) formation and cell surface hydrophobicity (csh) are all virulence traits involved in the pathogenicity of candida. post-antifungal effect (pafe) also have a bearing on pathogenicity and virulence of candida. candida dubliniensis is associated with oral and systemic candidosis, which can be managed with caspofungin. there is no published information on caspofungin-induced pafe and its impact on adhesion t ... | 2016 | 26850765 |
| survey and analysis of simple sequence repeats (ssrs) in three genomes of candida species. | simple sequence repeats (ssrs) or microsatellites, which composed of tandem repeated short units of 1-6 bp, have been paying attention continuously. here, the distribution, composition and polymorphism of microsatellites and compound microsatellites were analyzed in three available genomes of candida species (candida dubliniensis, candida glabrata and candida orthopsilosis). the results show that there were 118,047, 66,259 and 61,119 microsatellites in genomes of c. dubliniensis, c. glabrata and ... | 2016 | 26883055 |
| prevalence and antifungal susceptibility of candida albicans and its related species candida dubliniensis and candida africana isolated from vulvovaginal samples in a hospital of argentina. | candida africana taxonomical status is controversial. it was proposed as a separate species within the candida albicans species complex; however, phylogenetic analyses suggested that it is an unusual variety of c. albicans. the prevalence of c. albicans-related species (candida dubliniensis and c. africana) as vulvovaginal pathogens is not known in argentina. moreover, data on antifungal susceptibility of isolates causing vulvovaginal candidiasis is scarce. the aims of this study were to establi ... | 2016 | 26922471 |
| production of virulence factors in candida strains isolated from patients with denture stomatitis and control individuals. | the aim of this study was to evaluate the production of virulence factors in candida isolates from the oral cavities of 50 patients with different degrees of denture stomatitis (ds, type i, ii and iii) and 50 individuals without signs of ds. we evaluated the enzymatic and hemolytic activities, the biofilm formation, and the cell surface hydrophobicity (csh) in all isolates. germ tube (gt) production was also evaluated in candida albicans and candida dubliniensis isolates. in c. albicans and c. d ... | 2016 | 26971635 |
| evaluation of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry to differentiate between candida albicans and candida dubliniensis. | matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (maldi-tof-ms) analysis in conjunction with the direct formic acid (fa) sample processing method was evaluated for the ability to differentiate the closely related species of candida albicans and candida dubliniensis. the results showed that maldi-tof-ms, using the direct fa method, was reliable to differentiate between these species. | 2016 | 26971641 |
| 7-hydroxycalamenene effects on secreted aspartic proteases activity and biofilm formation of candida spp. | the 7-hydroxycalamenenene-rich essential oil (eo) obtained from the leaves of croton cajucara (red morphotype) have been described as active against bacteria, protozoa, and fungi species. in this work, we aimed to evaluate the effectiveness of 7-hydroxycalamenenene against candida albicans and nonalbicans species. | 2016 | 27019560 |
| meningitis caused by candida dubliniensis in a patient with cirrhosis: a case report and review of the literature. | candida species, including candida dubliniensis, are a rare cause of meningitis. herein, we report the second case of c. dubliniensis meningitis in a 49-year-old man with a history of hepatitis c virus-related cirrhosis, substance use disorder, and recent exposure to intravenous antibiotic therapy, presenting with confusion, abnormal gait, and urinary incontinence. magnetic resonance imaging (mri) of the brain showed marked hydrocephalus and leptomeningeal enhancement. initial cerebrospinal flui ... | 2016 | 27038312 |
| development of candida-specific real-time pcr assays for the detection and identification of eight medically important candida species. | culture-based identification methods have been the gold standard for the diagnosis of fungal infection. currently, molecular technologies such as real-time pcr assays with short turnaround time can provide desirable alternatives for the rapid detection of candida microbes. however, most of the published pcr primer sets are not candida specific and likely to amplify dna from common environmental contaminants, such as aspergillus microbes. in this study, we designed pan-candida primer sets based o ... | 2016 | 27103821 |
| experimental conical-head abutment screws on the microbial leakage through the implant-abutment interface: an in vitro analysis using target-specific dna probes. | the aim of this in vitro study was to identify and quantify up to 38 microbial species from human saliva penetrating through the implant-abutment interface in two different implant connections, external hexagon and tri-channel internal connection, both with conventional flat-head or experimental conical-head abutment screws. | 2016 | 27198721 |
| a substituted sulfonamide and its co (ii), cu (ii), and zn (ii) complexes as potential antifungal agents. | a sulfonamide 1-tosyl-1-h-benzo(d)imidazol-2-amine (tbza) and three new complexes of co(ii), cu(ii), and zn(ii) have been synthesized. the compounds have been characterized by elemental analyses, ftir, (1)h, and (13)c-nmr spectroscopy. the structure of the tbza, and its co(ii) and cu(ii) complexes, was determined by x-ray diffraction methods. tbza and its co(ii) complex crystallize in the triclinic p-1 space group, while the cu(ii) complex crystallizes in the monoclinic p21/c space group. antifu ... | 2016 | 27232977 |
| the gray phenotype and tristable phenotypic transitions in the human fungal pathogen candida tropicalis. | phenotypic plasticity, the ability to switch between different morphological types, plays critical roles in environmental adaptation, leading to infections, and allowing for sexual reproduction in pathogenic candida species. candida tropicalis, which is both an emerging human fungal pathogen and an environmental fungus, can switch between two heritable cell types termed white and opaque. in this study, we report the discovery of a novel phenotype in c. tropicalis, named the gray phenotype. simil ... | 2016 | 27246518 |
| etiologic agents and antifungal susceptibility of oral candidosis from romanian patients with hiv-infection or type 1 diabetes mellitus. | this is the first romanian investigation of oral candidosis in patients suffering of hiv-infection or type 1 diabetes mellitus (t1dm). candida albicans was the dominant species in both types of isolates: n = 14 (46.7%) in t1dm, n = 60 (69.8%) in hiv. the most frequent non-albicans candida spp. were candida kefyr (n = 6; 20%) in t1dm and candida dubliniensis (n = 8; 9.3%) in hiv. resistance to fluconazole was detected only in the hiv non-albicans candida group (n = 8; 9.3%). all isolates were sus ... | 2016 | 27282005 |
| vapour and liquid-phase artemisia annua essential oil activities against several clinical strains of candida. | candida spp. are often the cause of infection in immune-compromised individuals. they are characterized by a strong resistance to antimicrobial drugs and disinfectants. the activity of artemisia annua essential oil against candida spp. was determined by vapour contact and microdilution assay. the oil was characterized by the presence of oxygenated monoterpenes (more than 75 % of the constituents), mainly represented by the irregular monoterpene artemisia ketone (ca. 22 %), and the widespread mon ... | 2016 | 27286334 |
| epidemiologic and microbiologic evaluation of nosocomial infections associated with candida spp in children: a multicenter study from istanbul, turkey. | the purpose of this study was to establish species distribution of candida isolates from pediatric patients in istanbul, turkey, and to determine risk factors associated with nosocomial candida infections. | 2016 | 27339794 |
| candida dubliniensis pneumonia: a case report and review of literature. | candida dubliniensis is an uncommon species of candida which has been implicated in fungal pneumonia only very rarely. we present the case of a 75-year-old man with laryngeal cancer undergoing chemotherapy on broad-spectrum antibiotics and tuberculosis therapy with blood and endotracheal cultures positive for c. dubliniensis. subsequent autopsy was performed with postmortem lung cultures positive for c. dubliniensis and lung histopathology demonstrating an invasive fungal infection. molecular an ... | 2016 | 27342836 |
| fungal epidemiology and diversity in cystic fibrosis patients over a 5-year period in a national reference center. | the knowledge on prevalence rates of yeasts and moulds in patients with cystic fibrosis (cf) in germany is scarce. the aim of this report is to give an overview of the diversity and epidemiology of fungal species in cf patients. over a 5-year period, all fungal isolates cultured from microbiological specimen from cf patients were recorded. beside standard bacteriological culture media two fungal media were used for cultivation. species were identified by microscopy, biochemical profiling, maldi- ... | 2016 | 27364649 |
| in vitro antifungal activity of different components of centratherum anthelminticum and ocimum sanctum seed oils and their synergism against oral pathogenic fungi. | background. opportunistic fungal infections like candidiasis are common in the oral cavity. in recent years candida species have shown resistance against a number of synthetic drugs. this study assessed the antifungal activity of centratherum anthelminticum and ocimum sanctum seed oils against six common pathogenic candida strains. synergistic activity of the major oil components was also studied. methods. antifungal activity of centratherum anthelminticum and ocimum sanctum seed oils were teste ... | 2016 | 27429725 |
| postantifungal effect of caspofungin against the candida albicans and candida parapsilosis clades. | killing and postantifungal effects could be relevant for the selection of optimal dosing schedules. this study aims to compare time-kill and postantifungal effects with caspofungin on candida albicans (c. albicans, candida dubliniensis, candida africana) and candida parapsilosis (c. parapsilosis, candida metapsilosis, candida orthopsilosis) clades. in the postantifungal effect experiments, strains were exposed to caspofungin for 1 h at concentrations 0.12-8 μg/ml. time-kill experiments were cond ... | 2016 | 27492134 |
| prevalence of periodontopathogens and candida spp. in smokers after nonsurgical periodontal therapy - a pilot study. | this pilot study aimed to evaluate the influence of smoking on clinical and microbiological parameters after nonsurgical periodontal therapy. forty-eight subjects were grouped into smokers (sm, n = 24) and nonsmokers (ns, n = 24) and paired according to gender, age, ethnicity, and periodontal status. both groups received oral hygiene education and scaling and root planing. clinical evaluation was performed using plaque index (pi), bleeding on probing (bop), pocket probing depth (ppd), gingival r ... | 2016 | 27556680 |
| candida species diversity and antifungal susceptibility patterns in oral samples of hiv/aids patients in baja california, mexico. | candidiasis is the most common opportunistic fungal infection in hiv patients. the aims of this study were to identify the prevalence of carriers of candida, candida species diversity, and in vitro susceptibility to antifungal drugs. in 297 hiv/aids patients in baja california, mexico, candida strains were identified by molecular methods (pcr-rflp) from isolates of oral rinses of patients in tijuana, mexicali, and ensenada. 56.3% of patients were colonized or infected with candida in tijuana, th ... | 2016 | 27630251 |
| real-time pcr analysis of fungal organisms and bacterial species at peri-implantitis sites. | the potential role of fungal organisms and their co-aggregation with either periodontopathogens or opportunistic pathogens at peri-implantitis sites is unknown. the aim of the present study was to qualitatively/quantitatively analyze and correlate fungal organisms and bacterial species at peri-implantitis sites. | 2015 | 27747631 |
| identification of a second pad1 in brettanomyces bruxellensis lamap2480. | volatile phenols are aromatic compounds produced by some yeasts of the genus brettanomyces as defense against the toxicity of hydroxycinnamic acids (p-coumaric acid, ferulic acid and caffeic acid). the origin of these compounds in winemaking involves the sequential action of two enzymes: coumarate decarboxylase and vinylphenol reductase. the first one converts hydroxycinnamic acids into hydroxystyrenes, which are then reduced to ethyl derivatives by vinylphenol reductase. volatile phenols derive ... | 2017 | 27771809 |
| echinocandin resistance in candida species isolates from liver transplant recipients. | liver transplant recipients are at risk of invasive fungal infections, especially candidiasis. echinocandin is recommended as prophylactic treatment but is increasingly associated with resistance. our aim was to assess echinocandin drug resistance in candida spp. isolated from liver transplant recipients treated with this antifungal class. for this, all liver-transplanted patients in a university hospital (créteil, france) between january and june of 2013 and 2015 were included. susceptibilities ... | 2017 | 27855078 |
| candida species from oral cavity of hiv-infected children exhibit reduced virulence factors in the haart era. | this study aimed to assess, in vitro, the biofilm viability and the phospholipase and protease production of candida spp. from the saliva of hiv infected children and healthy controls, and to correlate the results with the use of medical data. a total of 79 isolates were analyzed: 48 candida albicans isolates (33/15) and 20 candida parapsilosis sensu lato complex isolates (12/8) (from hiv/control patients, respectively), and 8 candida krusei, 1 candida tropicalis, 1 candida dubliniensis and 1 ca ... | 2017 | 27913142 |
| susceptibility of candida albicans and candida dubliniensis to photodynamic therapy using four dyes as the photosensitizer. | oral candidiasis is the most common opportunistic infection affecting the human oral cavity. photodynamic therapy, as one of its proposed treatment modalities, needs a distinct dye for achieving the best effect. | 2016 | 27942552 |
| can serums be replaced by mueller-hinton agar in germ tube test? | the germ tube test (gtt) is inexpensive, easy, and well-defined test that differentiates candida albicans (excluding candida dubliniensis and candida africana) from other species. the aim of this study was to evaluate various serums (i.e., human, rabbit, horse, and fetal bovine serum) used in the gtt and mueller-hinton agar (mha). | 2017 | 27958248 |
| cytotoxic and antimicrobial effects of indium(iii) complexes with 2-acetylpyridine-derived thiosemicarbazones. | complexes [in(2ac4oclph)cl2(meoh)] (1), [in(2ac4pfph)cl2(meoh)] (2), [in(2ac4pclph)cl2(meoh)] (3) and [in(2ac4piph)cl2(meoh)] (4) were obtained with n(4)-ortho-chlorophenyl-2-acetylpyridine thiosemicarbazone (h2ac4oclph), n(4)-para-fluorophenyl-2-acetylpyridine thiosemicarbazone (h2ac4pfph), n(4)-para-chlorophenyl-2-acetylpyridine thiosemicarbazone (h2ac4pclph) and n(4)-para-iodophenyl-2-acetylpyridine thiosemicarbazone (h2ac4piph). theoretical studies suggested that the coordinated methanol mol ... | 2017 | 28009892 |
| activity of a long-acting echinocandin (cd101) and seven comparator antifungal agents tested against a global collection of contemporary invasive fungal isolates in the sentry 2014 antifungal surveillance program. | the activity of cd101 and comparator antifungal agents against 606 invasive fungal isolates collected worldwide during 2014 was evaluated using the clinical and laboratory standards institute (clsi) method. all candida albicans (n = 251), candida tropicalis (n = 51), candida krusei (n = 16), and candida dubliniensis (n = 11) isolates were inhibited by ≤0.12 μg/ml of cd101 and were susceptible or showed wild-type susceptibility to the other echinocandins tested. five c. glabrata isolates (n = 100 ... | 2017 | 28052853 |
| in vitro antifungal susceptibility of oral candida isolates from patients suffering from caries and chronic periodontitis. | caries and chronic periodontitis are common oral diseases where a higher candida colonization is reported. antifungal agents could be adjuvant drugs for the therapy of both clinical conditions. the aim of the current study has been to evaluate the in vitro activities of conventional and new antifungal drugs against oral candida isolates from patients suffering from caries and/or chronic periodontitis. in vitro activities of amphotericin b, fluconazole, itraconazole, miconazole, nystatin, posacon ... | 2017 | 28124220 |
| [evaluation of pna-fish method for direct identification of candida species in blood culture samples and its potential impact on guidance of antifungal therapy]. | early antifungal therapy has a major influence on survival in candidemia. rapid identification of the species has importance for the treatment, prediction of the species-specific primary resistance and variable antifungal susceptibility. recently, molecular-based methods attempt to reduce the time between the positive signal of a blood culture and identification of the fungus. pna-fish (peptide nucleic acid fluorescence in situ hybridization) assay distinguishes a number of frequently isolated c ... | 2016 | 28124963 |
| [cancer and mycoses and literature review]. | various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. there is less evidence concerning the implication of fungal infection in carcinogenesis. the role of chronic candida infection in the development of squamous cell carcinoma has been suspected for years. candida sp are more prevalent in potentially malignant disorder and cancer of the oral mucosa. other epidemiological evidence of a link between candida infection and cancer is what is observ ... | 2017 | 28188605 |
| enlightening the role of subdomains in the catalytic behavior of lipases/acyltransferases homologous to cplip2 through rational design of chimeric enzymes. | the lipases/acyltransferases homologous to cplip2 of candida parapsilosis catalyze efficiently acyltransfer reactions in lipid/water media with high water activity (aw > 0.9). the characterization of two new enzymes of this family, cdulac from candida dubliniensis and callac8 from candida albicans, was performed. despite their 82% identity, these 2 enzymes have significant differences in their catalytic behavior. to understand the role played by the different subdomains of these proteins (the ma ... | 2017 | 28258600 |
| structure-based functional annotation of hypothetical proteins from candida dubliniensis: a quest for potential drug targets. | candida dubliniensis is an emerging pathogenic yeast in humans and infections are usually restricted to mucosal parts of the body. however, its presence in specimens of immunocompromised individuals, especially in hiv-positive patients, is of major medical concern. there is a large fraction of genomes of c. dubliniensis in the database which are uncharacterized for their biochemical, biophysical, and/or cellular functions, and are identified as hypothetical proteins (hps). function annotation of ... | 2015 | 28324558 |
| antifungal activity of synthetic antiseptics and natural compounds against candida dubliniensis before and after in vitro fluconazole exposure. | this study evaluated the susceptibilities of oral candidiasis-derived candida albicans, fluconazole-resistant (fr) candida dubliniensis, and fluconazole-susceptible (fs) c. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (chx), cetylpyridinium chloride (cpc), and triclosan (trc)] and natural compounds (carvacrol, eugenol and thymol). | 2017 | 28327805 |
| evaluation of the in vitro activity of isavuconazole and comparator voriconazole against 2635 contemporary clinical candida and aspergillus isolates. | the in vitro activity of isavuconazole was determined for 1677 candida and 958 aspergillus isolates from 2012 to 2014 with voriconazole as comparator. | 2017 | 28373148 |
| population structure and molecular genetic characterization of 5-flucytosine-susceptible and -resistant clinical candida dubliniensis isolates from kuwait. | candida dubliniensis and candida albicans are two closely related species. although c. dubliniensis is less pathogenic, it has a higher propensity to develop resistance to fluconazole and some strains exhibit intrinsic resistance to 5-flucytosine (5-fc). all 5-fc-resistant isolates from kuwait were previously shown to belong to one of seven internal transcribed spacer (its) region of rdna-based haplotypes. this study performed fingerprinting of c. dubliniensis isolates by multilocus sequence typ ... | 2017 | 28380072 |
| prevalence of candida albicans, candida dubliniensis and candida africana in pregnant women suffering from vulvovaginal candidiasis in argentina. | vulvovaginal candidiasis (vvc) is a vulvovaginitis commonly diagnosed in gynecology care. in recent years, the taxonomy of the most important pathogenic candida species, such as candida albicans have undergone significant changes. | 2017 | 28385421 |
| oral mycobiome in community-dwelling elderly and its relation to oral and general health conditions. | oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. however, fungal colonization in a typical population without apparent symptoms and its associated conditions are poorly understood. in this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. | 2017 | 28419681 |
| phenotypic and genotypic detection of candida albicans and candida dubliniensis strains isolated from oral mucosa of aids pediatric patients. | the aim of this study was to assess a collection of yeasts to verify the presence of candida dubliniensis among strains isolated from the oral mucosa of aids pediatric patients which were initially characterized as candida albicans by the traditional phenotypic method, as well as to evaluate the main phenotypic methods used in the discrimination between the two species and confirm the identification through genotypic techniques, i.e., dna sequencing. twenty-nine samples of c. albicans isolated f ... | 2017 | 28423089 |
| methods of candida dubliniensis identification and its occurrence in human clinical material. | candida dubliniensis was reported as a new species in 1995. this species is often misidentified as candida albicans. the aims of this work were to determine the occurrence of c. dubliniensis in various clinical materials, to evaluate several ways to identify it and to examine the genetic variability of isolates. among 7706 isolates originally identified as c. albicans, 237 were identified as c. dubliniensis (3.1%). most of the c. dubliniensis isolates were obtained from the upper and lower respi ... | 2017 | 28516267 |
| usefulness of the non-conventional caenorhabditis elegans model to assess candida virulence. | invasive candidiasis is caused mainly by candida albicans, but other candida species have increasing etiologies. these species show different virulence and susceptibility levels to antifungal drugs. the aims of this study were to evaluate the usefulness of the non-conventional model caenorhabditis elegans to assess the in vivo virulence of seven different candida species and to compare the virulence in vivo with the in vitro production of proteinases and phospholipases, hemolytic activity and bi ... | 2017 | 28523422 |
| denaturing gradient gel electrophoresis profiles of bacteria from the saliva of twenty four different individuals form clusters that showed no relationship to the yeasts present. | the aim was to investigate the relationship between groups of bacteria identified by cluster analysis of the dgge fingerprints and the amounts and diversity of yeast present. | 2017 | 28577425 |
| prevalence of candida africana and candida dubliniensis, in vulvovaginal candidiasis: first turkish candida africana isolates from vulvovaginal candidiasis. | candida africana and c. dubliniensis are closely related species of c. albicans. current phenotypic methods are not suitable to accurately distinguish all the species belonging to the c. albicans complex. several molecular-based methods have recently been designed for discriminating among closely related candida species. the aim of this study was to establish the prevalence of c. dubliniensis and c. africana in vulvovaginal samples with phenotypic and genotypic methods. | 2017 | 28641919 |
| exoenzyme activity and possibility identification of candida dubliniensis among candida albicans species isolated from vaginal candidiasis. | vulvovaginal candidiasis (vvc) or vaginal candidiasis is a common fungal infection of the genitals causing inflammation, irritation, itching, and vaginal discharge. common yeast infections are caused by the yeast species c. albicans. however, there are other species of candida such as c. dubliniensis which are considered as the causative agents of this infection. hydrolytic enzymes such as proteinase and coagulase are known as virulence factors. the aim of this study was the molecular confirmati ... | 2017 | 28642006 |
| comparison of duplex pcr and phenotypic analysis in differentiating candida dubliniensis from candida albicans from oral samples. | candida dubliniensis shares a wide range of phenotypic characteristics with candida albicans including a common trait called germ tube positivity. hence, laboratory differentiation of these two species is cumbersome. duplex pcr analyses for c. albicans and c. dubliniensis was performed directly on dna extracted from a total of 122 germ tube positive isolates derived from 100 concentrated oral rinse samples from a random cohort of diabetics attending a clinic in sri lanka. these results were conf ... | 2017 | 28658945 |
| comparative evaluation of six chromogenic media for presumptive yeast identification. | the present study was undertaken to evaluate the discrimination ability of six chromogenic media in presumptive yeast identification. | 2017 | 28663328 |
| molecular identification and in-vitro antifungal susceptibility testing of candida species isolated from patients with onychomycosis. | candida species are the most opportunistic fungi affecting the nails and resulting in onychomycosis. in this study, we identified and evaluated in-vitro susceptibility of the recovered isolates against fluconazole (flc), voriconazole (vrc), and clotrimazole (clt) using the clinical and laboratory standards institute (clsi) m27-a3 document. | 2015 | 28681001 |
| killing activity of micafungin against candida albicans, c. dubliniensis and candida africana in the presence of human serum. | we compared killing activity of micafungin in time-kill experiments in rpmi-1640 with and without 50% serum against candida albicans, candida dubliniensis and candida africana reference strains and clinical isolates. killing rates (k values) were determined for each strain and concentration. in rpmi-1640 mic ranges were 0.015-0.03, 0.015-0.03 and 0.015 mg/l against c. albicans, c. dubliniensis and c. africana, respectively. in 50% serum mic values for the three species increased 16- to 64-fold. ... | 2017 | 28699056 |
| anticandidal activity of extracts and a novel compound, amnomopin, isolated from petriella setifera. | a novel triterpenoidal compound named 'amnomopin' (3β-diglucoside-5,12-28-oic acid), which is named iupac as 3-o-(2' ➔ 1″diglucoside)1,2,3,4,4a,5,6,6a,6b,7,9,10,11,12,12a,12b,13,14b-octadecahydro-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethylpicene-4a-carboxylic acid, was isolated from the extract petriella setifera. the total alcoholic extract of p. setifera showed a great activity against clinically isolated candida species, including candida albicans, candida dubliniensis, candida famata, candida g ... | 2017 | 28730719 |
| fungi of the genus rhodotorula isolated from the oral cavity of oncologic patients with colorectal cancer | this paper concerns the frequency of occurrence and enzymatic activity of fungi of the genus rhodotorula isolated from the oral cavity of patients with colorectal cancer. swabs from the oral cavity were subjected to standard mycological diagnostic procedures; enzymatic activity of the fungi was evaluated using and api zym test by biomereux. the fungi of the genus rhodotorula were noted in 22.5% positive isolates originating from women and 25.7% positive isolates originating from men. they includ ... | 2017 | 28741338 |
| persistence of candida dubliniensis and lung function in patients with cystic fibrosis. | candida dubliniensis is an emerging yeast and demonstrated a high adherence property to cystic fibrosis respiratory tract. therefore, it is important to determine the persistence of c. dubliniensis and to assess the possible relationship to the body mass index (bmi) and forced expiratory volume in 1st second (fev1). | 2017 | 28747217 |
| prevalence and antifungal susceptibility of candida species in a tertiary care hospital in islamabad, pakistan. | to determine the prevalence and antifungal susceptibility pattern of candida species. | 2017 | 28770873 |