Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| expression of the s-coded genes of lymphocytic choriomeningitis arenavirus using a baculovirus vector. | a dna copy of the lymphocytic choriomeningitis virus (lcmv, we strain)s rna species has been inserted in both orientations into plasmids containing a 7.1 kb dna sequence of the baculovirus autographa californica nuclear polyhedrosis virus (acnpv). the inserts were placed behind the polyhedrin gene promoter of acnpv and in the place of the nucleotide sequences including and flanking the polyhedrin gene translation initiation codon. the derived plasmids were used to obtain recombinant acnpv viruse ... | 1986 | 3525745 |
| antiviral antibody-producing cells in parenchymatous organs during persistent virus infection. | in mice persistently infected with lymphocytic choriomeningitis virus (lcmv), the parenchymatous organs contain infiltrates of mononuclear cells, the sizes and numbers of which vary between strains and become more numerous and extensive when the animals grow older. histologically, these were found to possess a tissue-like structure, and by use of immunohistologic procedures they were shown to contain plasma cells secreting igm and igg. cells of kidneys, livers, brains, and spleens of lcmv carrie ... | 1987 | 3546579 |
| site-specific antibodies define a cleavage site conserved among arenavirus gp-c glycoproteins. | arenaviruses share a common strategy for glycoprotein synthesis and processing in which a mannose-rich precursor glycoprotein, termed gp-c in lymphocytic choriomeningitis virus (lcmv), is posttranslationally processed by oligosaccharide trimming and proteolytic cleavage to yield two structural glycoproteins, gp-1 and gp-2. mapping the orientation and proteolytic cleavage site(s) in such polyproteins has traditionally required direct protein sequencing of one or more of the cleaved products. this ... | 1987 | 3546729 |
| molecular anatomy of viral disease. the george cotzias memorial lecture 1986. | 1987 | 3547169 | |
| baculovirus expression vectors: the requirements for high level expression of proteins, including glycoproteins. | the requirements for high level expression of three foreign proteins using the polyhedrin gene promoter of autographa californica nuclear polyhedrosis virus (acnpv, baculoviridae) have been investigated. in spodoptera frugiperda cells infected with the appropriate recombinant baculoviruses, the synthesis of the two s rna coded genes of lymphocytic choriomeningitis virus (lcmv; i.e. the nucleoprotein, n, and glycoprotein precursor, gpc), or the haemagglutinin gene of influenza a virus, appears to ... | 1987 | 3553425 |
| depression of virus-specific cytotoxic t-cell responses during murine malaria. | mice with self-limiting p. yoelii or fatal p. berghei infections exhibited a markedly impaired ability to mount specific splenic cytotoxic t-lymphocyte responses to immunization with infectious ectromelia (ev), vaccinia (vac), or lymphocytic choriomeningitis viruses (lcmv). lymph node responsiveness, however, was not impaired. primary ctl responses were depressed in mice immunized 7 days after p. berghei infection, while in p. yoelii-infected mice, depressed responses were detected only during t ... | 1987 | 3554117 |
| lymphocytic choriomeningitis virus can persistently infect thyroid epithelial cells and perturb thyroid hormone production. | although viral infection has been suspected as the cause of some thyroid disorders, there has been limited data to support this contention seriously. now we report the first evidence that lymphocytic choriomeningitis virus can persist in the thyroid gland, particularly thyroid epithelial cells in which thyroglobulin (tg) the precursor of thyroid hormone, is synthesized. concomitant with the infection of these cells is a significant reduction in tg mrna and in the level of circulating thyroid hor ... | 1987 | 3598562 |
| susceptibility of inbred syrian golden hamsters (mesocricetus auratus) to lethal disease by lymphocytic choriomeningitis virus. | an acutely lethal lcmv disease model has been established in the syrian golden hamster (mesocricetus auratus) in which lethality and disease are dependent upon both the inbred hamster strain and the lcmv strain. young adult inbred, male and female, hamsters were tested for lethal-disease susceptibility by lymphocytic choriomeningitis virus (lcmv) strains, we or armstrong (arm). with we inocula, pd4 and mha inbred hamsters were highly susceptible to a wasting disease. lvg and lhc inbred hamsters ... | 1987 | 3601946 |
| lack of correlation between serum titres of interferon alpha, beta, natural killer cell activity and clinical susceptibility in mice infected with two isolates of lymphocytic choriomeningitis virus. | intracerebral infection of adult immunocompetent mice with most strains of lymphocytic choriomeningitis virus (lcmv) caused a systemic infection and led to severe meningoencephalitis and death due to the induced t cell immune response. the susceptibility of congenic mice to the two plaque variants docile and aggressive of lcmv strain ubc was shown to be mouse strain-dependent. to investigate the possible correlation between acid-stable interferon (ifn) and natural killer (nk) cell responses and ... | 1987 | 3612089 |
| meningeal macrophages reflect lymphocytic choriomeningitis virus pathogenic phenotypes. | intracerebral (i.c.) infection of adult mice with lymphocytic choriomeningitis (lcm) virus can result in acute lethal central nervous system (cns) disease which is the result of the host's thymus-derived lymphocyte (t cell) response against the virus. whether the specific effector function of the t cell is that of a cytotoxic cell (tc) or a delayed-type hypersensitivity cell (td) is still under debate. we assumed that if td cells were important in pathogenesis then accessory cells in the brain ( ... | 1987 | 3629192 |
| immune therapy of a persistent and disseminated viral infection. | the mechanism of viral clearance was studied by using the mouse model of chronic infection with lymphocytic choriomeningitis virus. distinct patterns of viral clearance and histopathology were observed in different organs after adoptive immune therapy of persistently infected (carrier) mice. clearance from the liver occurred within 30 days and was accompanied by extensive mononuclear cell infiltrates and necrosis of hepatocytes. infectious virus and viral antigen were eliminated concurrently. th ... | 1987 | 3682061 |
| immunosuppression-induced susceptibility of inbred hamsters (mesocricetus auratus) to lethal-disease by lymphocytic choriomeningitis virus infection. | the role of the immune response in the pathogenesis of lethal and non-lethal lymphocytic choriomeningitis virus (lcmv)-infections of young adult syrian golden hamsters (mesocricetus auratus) of different strains was examined using immunosuppressive treatment with cyclophosphamide or with whole-body gamma-irradiation. in all hamsters, the lcmv strains, we and armstrong (arm), caused systemic infections and induced comparable serum lcmv-antibody titers. however, lethal wasting-disease occurred whi ... | 1987 | 3689153 |
| contamination of transplantable murine tumors with lymphocytic choriomeningitis virus. | lymphocytic choriomeningitis virus (lcmv) was isolated from a transplantable tumor after mice bearing the tumor began to die prematurely. tumor lines, mice and laboratory personnel that had an association with the index laboratory were tested for lcmv infection. testing of tumor lines from the index laboratory and four other laboratories revealed that 16 of 55 tumor samples used in vivo and one of eight tumor samples maintained in vitro were contaminated with lcmv. laboratory personnel and unino ... | 1986 | 3702331 |
| [incidence and features of neuroinfections induced by lymphocytic choriomeningitis virus]. | a follow-up examination of blood sera and cerebrospinal fluid was carried out in 413 patients with various neuroinfections and related diseases. the modern immunological methods were employed: the complement fixation test, the fluorescent antibody test as well as immuno-enzymic and radioimmunoassays. it was established that 8.5% of serous meningitides and 12% of encephalitides were induced by lymphocytic choriomeningitis (lcm) virus. the verified diseases were subjected to a clinical analysis. i ... | 1986 | 3705819 |
| oligoclonal immunoglobulin bands in cerebrospinal fluid of a patient with lymphocytic choriomeningitis. | we describe a patient with meningitis caused by lymphocytic choriomeningitis virus. oligoclonal igg bands were found in the patient's cerebrospinal fluid during acute and convalescent stages of the illness, and results of liver function tests were abnormal. acute attacks of lymphocytic choriomeningitis virus infection in humans can be added to the list of diseases associated with cerebrospinal fluid oligoclonal igg. | 1986 | 3707091 |
| purification and target cell range of in vivo elicited blast natural killer cells. | blast natural killer (nk) cells were elicited in the spleens of mice by treatments with the interferon inducers lymphocytic choriomeningitis virus (lcmv) or polyinosinic-polycytidylic acid (poly i:c). the blast-nk cells, separated on the basis of size by centrifugal elutriation, were compared with blast cytotoxic t lymphocytes (ctl) generated during infection with lcmv. in vivo treatments with antibody to asialo gm1 (agm1) blocked the appearance of blast-nk cells but not blast-ctl. antibody and ... | 1986 | 3722814 |
| analysis of lymphocytic choriomeningitis virus gene expression in acutely and persistently infected mice. | 1986 | 3724658 | |
| antiviral antibody production in parenchymatous organs of lymphocytic choriomeningitis virus carrier mice. enumeration of antibody-producing cells and immunohistochemical investigation of mononuclear cell infiltrates. | 1986 | 3724659 | |
| perturbation of endocrine functions during persistent infection of mice with lymphocytic choriomeningitis virus. | 1986 | 3724660 | |
| the use of lymphocytic choriomeningitis virus reassortants to map viral genes causing virulence. | 1986 | 3724665 | |
| dissecting the molecular anatomy of persistent infection with lymphocytic choriomeningitis virus. | 1986 | 3724670 | |
| mechanisms of lymphocytic choriomeningitis virus-induced hemopoietic dysfunction. | results of this study showed that lymphocytic choriomeningitis virus infection causes a marked activation of natural killer (nk) cells not only in the spleen but also in the bone marrow. this activity reached its peak at about day 3 of infection and declined after days 6 to 7. enhanced nk cell activity was found to correlate with decreased receptivity for syngeneic stem cells in bone marrow and spleen, with the notable exception that decreased receptivity persisted longer in bone marrow. treatme ... | 1986 | 3735489 |
| nucleotide sequence of the glycoprotein gene and intergenic region of the lassa virus s genome rna. | two overlapping cdna clones corresponding to the 5' region of the lassa virus s genome rna were isolated and their nucleotide sequences determined. similar to pichinde and lymphocytic choriomeningitis viruses (lcmv), lassa virus has an ambisense s rna. the precursor to the viral glycoproteins (gpc) is encoded in viral rna sequence originating at position 56 and terminating at position 1529 from the 5' terminus of the s rna. a short, noncoding, intergenic region capable of forming a hairpin struc ... | 1986 | 3750844 |
| perturbation of differentiated functions in vivo during persistent viral infection. iii. decreased growth hormone mrna. | lymphocytic choriomeningitis virus (lcmv) persistent infection that results from the inoculation of c3h/st newborn mice causes growth hormone (gh) deficiency and associated disease characterized by both reduced weight and serum glucose levels. molecular analysis of pituitary nucleic acids shows gh deficient mice have, on average, fivefold reduced levels of gh mrna although the histopathology of such gh producing cells is normal. northern blots indicate that the length of gh mrna is comparable in ... | 1987 | 3811236 |
| molecular characterization of the genomic s rna segment from lymphocytic choriomeningitis virus. | we have used cdna clones derived from the genomic s rna segment of lymphocytic choriomeningitis virus (lcmv), armstrong strain, as hybridization probes to monitor virus gene expression during acute infections. our results with strand-specific probes confirm the ambisense character of the lcmv s rna segment and document the presence of both genomic sense and genomic complementary sense rna species over the time course of infection. we have used nucleotide sequence information to predict primary a ... | 1987 | 3824905 |
| mechanism of recovery from acute virus infection. i. role of t lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice. | adult mice were infected by i.v. inoculation with 10(3) mouse infectious doses of lymphocytic choriomeningitis virus (lcm virus). despite widespread replication of the agent, overt illness did not develop; histopathologic alterations were moderate. high virus concentrations were attained in the spleen, which was chosen for further study. cytotoxic spleen t cell responses were found to vary among inbred mouse strains, and as a rule, these were correlated with other virus-specific cell-mediated im ... | 1985 | 3871115 |
| immune t cells can protect or induce fatal neurological disease in murine lymphocytic choriomeningitis. | adoptively transferred immune spleen cells induce fatal neurological disease in cyclophosphamide-suppressed recipients injected intracerebrally (ic) with a large, but not small, dose of neurotropic lymphocytic choriomeningitis (lcm) virus. the elimination of virus from brain in the latter group, which survives without developing symptoms, depends upon the presence of lyt 2+ lymphocytes. however removal of lyt 2+ subset which is cytotoxic in vitro does not diminish the severity of the inflammator ... | 1985 | 3871371 |
| participation of cyclophosphamide-resistant t cells in murine lymphocytic choriomeningitis. | a severe inflammatory process can be induced by transferring lymphocytic choriomeningitis virus (lcmv)-immune spleen cell populations into cyclophosphamide (cy)-suppressed, lcmv-infected recipients. the extent of cellular invasion can be quantified accurately by counting cells obtained from the cisterna magna. the underlying lymphocyte-target cell interactions are apparently very specific, with massive cellular invasion being dependent on the donor and recipient sharing class i major histocompat ... | 1985 | 3871962 |
| lack of correlation between cytotoxic t lymphocytes and lethal murine lymphocytic choriomeningitis. | adoptive transfer of lymph node and spleen cells from mice infected with lcm virus to similarly infected immunocompromised recipients has been the classic way to demonstrate the lethal role of t cells in the cns disease caused by this virus. isolation and adoptive transfer techniques are presented here which show that thy-1+ cells isolated from the meningeal infiltrates (mi) of lcm virus-infected mice possess this property. we compared various t cell functions of mi cells taken from mice infecte ... | 1985 | 3873496 |
| consequences of a single ir-gene defect for the pathogenesis of lymphocytic choriomeningitis. | the h-2ld allele has been identified by others as the sole ir gene in the h-2d haplotype for the cytotoxic t lymphocyte (ctl) response to mouse lymphocytic choriomeningitis virus (lcmv). the balb/c-h-2dm2 (c-h-2dm2) mutant lacks h-2ld, and thus should be ideal for assessing the contribution of virus-immune ctl to lcm immunopathology. comparison of the c-h-2dm2 mice with congenic balb/c mice revealed that there is a delay of about 24 h in the onset of severe inflammatory process and symptoms in t ... | 1985 | 3874159 |
| expression of asialo gm1 and other antigens and glycolipids on natural killer cells and spleen leukocytes in virus-infected mice. | the sensitivities of mouse natural killer (nk) cells to various antisera and complement were analyzed at different time points after acute lymphocytic choriomeningitis virus infection. under these conditions nk cell activity peaks 3 days and virus-specific cytotoxic t cell activity 7 days after infection. the sensitivity of the cytotoxic activities to antibodies to asialo gm1 (agm1), nk 1.2 alloantigen, and ly 5 was in the order endogenous nk greater than day 3 nk greater than day 7 nk. day 7 cy ... | 1985 | 3875791 |
| exquisite specificity of adoptive immunization in arenavirus-infected mice. | lymphocytic choriomeningitis virus (lcmv)-infected mice can be adoptively immunized with t cells from immune mice sharing mhc compatibility in h-2k or d, suggesting direct cytotoxic effects of t cells in vivo. however, t cells, upon recognition of an appropriate target, secrete lymphokines which may be capable of mediating antiviral effects nonspecifically. in this report we show that lcmv-immune cells reduced lcmv spleen titers in mice infected with lcmv alone or with lcmv and pichinde virus (p ... | 1985 | 3877492 |
| susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic t cell activity, as well as with footpad swelling reaction, and all three are regulated by h-2d. | the lymphocytic choriomeningitis virus (lcmv) isolates docile (d) and aggressive (a) of pfau et al. were studied in various strains of mice. disease susceptibility, assessed as mortality and time to death to lcmv-d or -a varied greatly amongst mouse strains, and all four possible susceptibility patterns were observed: susceptibility to both (e.g. swr/j), resistance to both (e.g. dba/2), susceptibility to a but resistance to d (c57bl/6), or vice versa (cba/j). irrespective of the virus isolate or ... | 1985 | 3877779 |
| mechanism of recovery from acute virus infection. ii. effect of treatment of mice with cyclosporin a on their ability to eliminate the lymphocytic choriomeningitis virus. | illness and death of mice infected by intracerebral inoculation with lymphocytic choriomeningitis virus are pathologic immune phenomena, and mice thus infected were protected when immunosuppressed with cyclosporin a (csa), although the virus multiplied extensively in all major organs. concentrations remained high as long as the drug was administered but declined when the treatment was discontinued; also, cytotoxic t lymphocytes appeared. virus elimination was slower and cytotoxic t cell activity ... | 1985 | 3877860 |
| consequences of cyclophosphamide treatment in murine lymphocytic choriomeningitis: evidence for cytotoxic t cell replication in vivo. | administration of a large dose (400 mg/kg) of cyclophosphamide (cy) prior to infection with lymphocytic choriomeningitis virus (lcmv) suppresses the virus-immune cytotoxic t lymphocyte (ctl) response. treatment with 150 mg/kg of cy before, at the time of, or on the day after lcmv infection has little effect on ctl function. in contrast, when given on 2-7 days after lcmv, this dose profoundly depresses the day-8 ctl response and delays the onset of neurological disease. administration of as littl ... | 1985 | 3877978 |
| mechanism of recovery from acute virus infection. iii. subclass of t lymphocytes mediating clearance of lymphocytic choriomeningitis virus from the spleens of mice. | spleen t lymphocytes from mice undergoing acute infection with lymphocytic choriomeningitis virus (lcm virus) were negatively selected by treatment with anti-lyt or anti-l3t4 antibodies and complement. the subsets thus obtained were tested for their potential to lyse lcm virus-infected target cells in vitro and to confer on infected syngeneic recipients the ability to eliminate virus rapidly from their spleens. both capacities were found to be associated with lyt-1-2+, l3t4- cells. previous stud ... | 1985 | 3878930 |
| virus and immune responses: lymphocytic choriomeningitis virus as a prototype model of viral pathogenesis. | 1985 | 3882190 | |
| virus persists in beta cells of islets of langerhans and infection is associated with chemical manifestations of diabetes. ii. morphologic observations. | persistence of lymphocytic choriomeningitis (lcm) virus in the islets of langerhans was associated with mild hyperglycemia and abnormal glucose tolerance test results. early histopathologic events consisted of occasional perivascular inflammatory mononuclear cells around both islet and acinar cells. morphometric studies showed an increase in the size of islets from virus-infected mice. by electron microscopy, lcm virions were found within infected beta cells. cytolytic injury of beta cells was m ... | 1985 | 3907367 |
| biology of cloned cytotoxic t lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus and in vitro properties. | we have generated lymphocytic choriomeningitis virus-specific, h-2-restricted cytotoxic thymus-derived lymphocyte (ctl) clones. by using these reagents in several in vitro assays with infected target cells, we show that ctls by themselves prevent the release of infectious virus into culture fluids and significantly lower the titers of infectious virus previously produced. this ability of cloned ctls is not influenced by monensin. however, monensin does abrogate the ability of ctls from spleens o ... | 1985 | 3918175 |
| characterization of scrapie agent isolated from sheep in japan. | a pathogenic agent isolated in mice from the brain of a sheep affected by scrapie-like disease was characterized. the incubation period of the disease in the primary transmission from the sheep to mice was longer than in the secondary and the tertiary transmission in the same strain of mice. progressive dilution of the inoculum caused prolongation of the incubation period. the infectivity of the agent in a 10% brain homogenate persisted, but decreased about 10(3) to 10(4) times after heating at ... | 1985 | 3930925 |
| sensitivity of lymphocytic choriomeningitis and tacaribe viruses to several physical factors. | a comparative study was performed as regards the behaviour of lymphocytic choriomeningitis virus (lcmv)--strains fo-2 and 522--and of tacaribe virus (strain tr 11573) at different temperatures and ph values. all the three arenavirus strains had a high thermosensitivity and were rapidly inactivated in an acid medium. lcmv was more sensitive to uv irradiation than tacaribe virus. the effect of sonication was also investigated. | 1986 | 3962179 |
| influence of several chemical reagents on lymphocytic choriomeningitis and tacaribe viruses. | the sensitivity of lymphocytic choriomeningitis virus (lcmv) and tacaribe virus to several chemical reagents was investigated. the viruses were sensitive to lipid solvents (ether, chloroform) and to detergents (sodium desoxycholate and triton x-100); they were rapidly inactivated by formalin, beta-propiolactone, hydrogen peroxide and chloramine b. the results obtained contribute to a more complete characterization of the biological features of the arenavirus group and may be useful for scientifi ... | 1986 | 3962180 |
| lymphocytic choriomeningitis virus. ix. properties of the nucleocapsid. | nucleocapsids (nc) of lymphocytic choriomeningitis (lcm) virus were obtained by treatment of purified infectious virus with detergent and salt at high concentrations, followed by gradient centrifugation. nc thus prepared contained 31 s rna, 23 s rna, and a protein with an apparent mol wt 63,000 and an isoelectric point ph 5.7 (p63), assumed to be the nucleoprotein. we had previously observed that the intact lcm virus contained two kinds of protein with mol wt 63,000 separable by their isoelectri ... | 1986 | 3962189 |
| the s rna segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoproteins 1 and 2. | the lymphocytic choriomeningitis virus (lcmv) genome consists of a large rna segment and a small rna segment. the three major structural proteins of this virus are an internal nucleoprotein and two surface glycoproteins. intertypic reassortants between the armstrong and we strains of lcmv were made to map proteins encoded by the lcmv genome segments. using monoclonal antibodies specific for the nucleoprotein and the glycoproteins of we and armstrong, we showed that the small rna segment of lcmv ... | 1985 | 3973970 |
| conserved sequences and coding of two strains of lymphocytic choriomeningitis virus (we and arm) and pichinde arenavirus. | analyses of the 3' end sequences of the small, s, and large, l, rna species of lymphocytic choriomeningitis (lcm) virus isolates arm and we, and dna clones of lcm-we, have shown that there are extensive rna sequence homologies between the 3' ends of the two rna species of both lcm strains. limited sequence data of dna clones representing the lcm-we l rna species indicate that a gene product (presumably the minor 200 kdalton virion protein) is coded in a viral-complementary mrna species. sequence ... | 1985 | 3984491 |
| appearance of antibodies to two viruses in cerebrospinal fluid of patients with aseptic meningitis. | two cases of aseptic meningitis with simultaneous presence of antibodies to lymphocytic choriomeningitis (lcm) and mumps viruses were observed. in the 1st patient antibodies to both viruses appeared in sera and cerebrospinal fluid (csf). the 2nd patient displayed rising serum antibodies to both viruses and csf antibodies to mumps virus. immunological findings and clinical features of the patients are discussed. | 1985 | 3984681 |
| different isotype profiles of virus-specific antibodies in acute and persistent lymphocytic choriomeningitis virus infection in mice. | the humoral immune response to lymphocytic choriomeningitis virus (lcmv) was analysed by the use of a sensitive elisa. our results show that lcmv carriers of the c3h strain, previously believed to be completely tolerant to the virus, do in fact produce lcmv-specific antibodies and, moreover, that a significant proportion of these antibodies belong to igg subclasses which are considered t-cell dependent. this finding, together with the fact that t-cell deficient mice made little or no lcmv-specif ... | 1985 | 4007926 |
| impairment in auditory and visual function follows perinatal viral infection in the rat. | acoustic startle reflexes are elicited by intense tone bursts but inhibited if weak bursts precede reflex elicitation. rats were infected by intracerebral inoculation with lymphocytic choriomeningitis virus (lcmv) at birth. compared to control animals, infected animals had higher elicitation and inhibition thresholds and showed recruitment at intense stimulus levels. histopathology revealed both cochlear and retinal degeneration. like some infectious agents in humans, perinatal exposure to lcmv ... | 1985 | 4019065 |
| genetic mapping of lymphocytic choriomeningitis virus pathogenicity: virulence in guinea pigs is associated with the l rna segment. | the armstrong ca 1371 (arm) and we strains of lymphocytic choriomeningitis virus (lcmv) differ in the ability to produce disease in adult guinea pigs. infection with the arm strain is not lethal, even at high virus doses (greater than 10,000 pfu), whereas the we strain causes 100% mortality even at low doses (less than 10 pfu). to determine the genetic basis of this virulence, intertypic reassortants were made between the arm and we strains of lcmv. the two reassortants with the genotypes we/arm ... | 1985 | 4020963 |
| necrosis of adipose tissue induced by sequential infections with unrelated viruses. | vaccinia virus infection in mice previously infected with and immune to lymphocytic choriomeningitis virus resulted in a clinical illness which neither virus alone induced. the main pathologic finding was extensive fat necrosis with a cellular infiltrate suggestive of delayed type hypersensitivity. vaccinia virus titers in adipose tissue of clinically ill mice were not higher than those in relevant control groups. this indicates that an unusual virus-induced disease can arise in an animal with a ... | 1985 | 4025507 |
| susceptibility to murine lymphocytic choriomeningitis maps to class i mhc genes--a model for mhc/disease associations. | susceptibility to some human diseases is linked, albeit weakly, to major transplantation antigens (hla) encoded by the major histocompatibility gene complex (mhc). here we have studied mhc/disease association in inbred strains of mice after intracerebral (i.c.) injection of lymphocytic choriomeningitis virus (lcmv). this route of infection leads to a lymphocytic choriomeningitis (lcm) which is not the result of direct cytopathic effects of the virus but is caused by the induced t-cell immune res ... | 1985 | 4033780 |
| perturbation of differentiated functions during viral infection in vivo. ii. viral reassortants map growth hormone defect to the s rna of the lymphocytic choriomeningitis virus genome. | lymphocytic choriomeningitis virus (lcmv) armstrong caused disordered growth and glucose metabolism secondary to growth hormone deficiency in infected c3h/st mice. in contrast, lcmv strain we replicated in fewer growth hormone-producing cells, failed to disrupt growth hormone synthesis, and did not cause growth hormone-induced disease in infected, matched controls. the generation of genetic reassortant viruses between the virulent strain of lcmv:armstrong and the avirulent strain, lcmv:we, is re ... | 1985 | 4060570 |
| complete sequence of the s rna of lymphocytic choriomeningitis virus (we strain) compared to that of pichinde arenavirus. | previous studies have reported that the 3' half of the small, s, rna species of the we strain of lymphocytic choriomeningitis (lcm) virus codes for the viral nucleoprotein in a subgenomic, viral-complementary, mrna species (romanowski, v. and bishop, d.h.l. (1985) virus res. 2, 35-51). the complete sequence of the lcm-we s rna has now been obtained, indicating that the 5' half of the rna codes for the viral glycoprotein precursor in a viral-sense sequence that does not overlap the n gene. it is ... | 1985 | 4060885 |
| viral contamination of a subline of toxoplasma gondii rh. | a subline of toxoplasma gondii rh was determined to be contaminated with a viral agent, apparently lymphocytic choriomeningitis virus. | 1985 | 4066035 |
| an apparent histoincompatibility between mice chronically infected with lymphocytic choriomeningitis virus and their uninfected syngeneic counterparts. | 1971 | 4101145 | |
| thoracic lymph duct cannulation of mice infected with lymphocytic choriomeningitis (lcm) and ectromelia viruses. | 1971 | 4109491 | |
| restriction of in vitro t cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. | 1974 | 4133807 | |
| cyclical phenomena in persistent virus infection. | 1974 | 4134995 | |
| binding of soluble immune complexes to human lymphoblastoid cells. ii. use of raji cells to detect circulating immune complexes in animal and human sera. | cells from a human lymphoblastoid cell line (raji), with b-cell characteristics, and having receptors for human igg fc, c3b, and c3d, were used in an immunofluorescence test as in vitro detectors of immune complexes in animal and human sera. by this test, as little as 200-300 ng aggregated human gamma globulin or immune complexes per ml serum could be detected. the receptors for igg fc on the raji cells were shown to be inefficient in detecting aggregated human gamma globulin and binding of aggr ... | 1974 | 4138539 |
| viral encephalitis. | 1973 | 4144386 | |
| [lcm virus-specific antigens]. | 1974 | 4154624 | |
| [new surface antigens on lcm virus-infected cells]. | 1974 | 4154625 | |
| [immunological phenomena in lcm virus-infected mice]. | 1974 | 4154626 | |
| [murine lymphocytic choriomeningitis: pathology of the lymphatic tissue]. | 1974 | 4154627 | |
| [new problems in tolerance induction]. | 1973 | 4156163 | |
| viruses in the aetiology of acute appendicitis. | 1966 | 4162203 | |
| a persistent and inapparent infection of l cells with the virus of lymphocytic choriomeningitis. | 1969 | 4186351 | |
| effect on the fetus of maternal infection with lymphocytic choriomeningitis (lcm) virus. | 1969 | 4186686 | |
| inability to induce tolerance to bovine gamma globulin in mice infected at birth with lymphocytic choriomeningitis virus. | 1970 | 4190943 | |
| biophysical and biochemical characterization of lymphocytic choriomeningitis virus. iv. strain differences. | biological, biochemical, and biophysical properties of three lymphocytic choriomeningitis (lcm) virus strains were compared. the biological property examined was the concentration range of virus which would, when injected into neonates, cause a carrier state. the dosage range for the ca1371 and traub strains was found to be as broad as the limits examined (5 to 100 ld(50) units/mouse). the wcp strain, however, would only produce carriers within a 3 to 5 ld(50) range. the biochemical properties e ... | 1968 | 4192659 |
| plaque size heterogeneity: a genetic trait of lymphocytic choriomeningitis virus. | all of the ten strains of lymphocytic choriomeningitis virus assayed on bhk 21/13s cells showed various degrees of plaque size heterogeneity. the amount of virus released from these plaques was usually very small because of rapid photodynamic inactivation by neutral red. when virus from large and small plaques of a specific strain was plated, the same distribution of plaque size was obtained from each clone. although it was shown that surface virus could possibly be randomly distributed at the t ... | 1970 | 4195608 |
| homologous interference of lymphocytic choriomeningitis virus. | 1973 | 4203238 | |
| [ultrastructural aspects of experimental infection by lymphocytic choriomeningitis virus]. | 1971 | 4259513 | |
| disease accompanying in utero viral infection. the role of maternal antibody in tissue injury after transplacental infection with lymphocytic choriomeningitis virus. | early, after in utero infection with lcm virus, swr/j and ha/icr mice developed manifestations of immune complex disease. observations based on nursing such mice with virus-infected, immune, or noninfected mouse mothers indicated that maternal antiviral antibody was responsible for the early immune complex glomerulonephritis. despite comparable viral persistance, in utero-infected offspring failed to develop glomerulonephritis when nursed by noninfected mouse mothers, but did when suckled by vir ... | 1972 | 4259667 |
| how the immune response to a virus can cause disease. | 1973 | 4264280 | |
| effect of immunosuppression on chronic lcm virus infection of mice. | c3h mice chronically infected with lcm virus were found to be lethally affected by small doses of immunosuppression which caused bone marrow aplasia but had no effect on the amount of virus carried by the mouse. humoral immune response of swr/j mice to acute lcm infection was found to be totally suppressed by repeated single doses of 300 r/wk with no alteration in the level of virus carried by the mouse. in contrast, the established anti-lcm humoral immune response encountered in mice chronicall ... | 1973 | 4270346 |
| [aleutian mink disease: a model of an immunopathological disease induced by virus (author's transl)]. | 1974 | 4279784 | |
| effect of certain murine pathogens on phagocytic activity. | 1965 | 4283903 | |
| some nuclear-substituted derivatives of alpha-methyldopa. | 1966 | 4291024 | |
| in vitro studies on the antiviral activity of 1, 3-bis(2-chloroethyl)-1-nitrosourea. | chemotherapy experiments carried out in vitro demonstrated that 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) was active against lymphocytic choriomeningitis virus and had an equivocal antiviral effect on semliki forest, herpes simplex, and vaccinia viruses. no antiviral effect was observed with bcnu against western equine encephalomyelitis, polio, and parainfluenza (ha-1) viruses. activity of the drug was determined by inhibition of viral-induced cytopathogenic effect in kb or chick embryo cells ... | 1966 | 4291237 |
| [cultivation of viruses in a suspension of continuous cells]. | 1968 | 4307008 | |
| [sensitivity of a referent human diploid cell strain wi-38 to different viruses. ii]. | 1970 | 4313215 | |
| [concept of viral infections--from cell level to individual host level]. | 1971 | 4325396 | |
| an evaluation of the mouse antibody production test for detecting three murine viruses. | 1971 | 4325691 | |
| alan watson gledhill. 4 june 1910--20 july 1967. | 1971 | 4330016 | |
| activation of spontaneous murine leukemia virus-related antigen by lymphocytic choriomeningitis virus. | persistent infection with lymphocytic choriomeningitis (lcm) virus activates a phenotypic expression of murine leukemia viruis-related antigen. nzb and (nzb x nzw)f(1) mice, which normally carry large amounts of gross virus, and c57bl/6 and nzw mice, which normally carry little virus, were infected with lcm virus. all had gross soluble antigen in their plasmas at 3 months of age, while noninfected matched controls of all strains did not. this effect was seen after infection with lcm virus that w ... | 1971 | 4330471 |
| antiviral activity of tobacco leaf on encephalomyocarditis (emc) virus infection. | 1971 | 4331947 | |
| [pathogenesis of virus diseases]. | 1970 | 4331981 | |
| immunodepression by oncogenic viruses. | 1972 | 4338188 | |
| [cornea and armstrong's virus. apropos of a case of recurrent epithelial keratitis]. | 1971 | 4339401 | |
| murine virus contaminants of leukemia viruses and transplantable tumors. | 1972 | 4343473 | |
| guillain-barré syndrome. occurrence following combined mumps-rubella vaccine. | 1973 | 4350682 | |
| slow viruses: role in persistent disease. | 1973 | 4350927 | |
| immune complex glomerulonephritis in one-year-old c57bl-6 mice induced by endogenous murine leukemia virus and erythrocyte antigens. | 1973 | 4356323 | |
| microbial flora and viral contact status of chinese hamsters (cricetulus griseus). | 1973 | 4357853 | |
| macrophage activation in mice infected with ectromelia or lymphocytic choriomeningitis viruses. | 1973 | 4358302 | |
| [defective particles in a virus population]. | 1973 | 4358704 | |
| interfering particles from a culture persistently infected with parana virus. | 1974 | 4361922 | |
| viral infections of the central nervous system. | 1974 | 4362722 | |
| cyclophosphamide-potentiated west nile viral encephalitis: relative influence of cellular and humoral factors. | 1974 | 4372273 |