Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [rapid staining methods for the detection of malaria parasites]. | 1985 | 2408783 | |
| ubiquity of the repetitive epitope of the cs protein in different isolates of human malaria parasites. | sporozoites of the human malaria plasmodium falciparum and plasmodium vivax obtained from a large number of endemic areas were screened with species-specific monoclonal antibodies that recognize the repeated epitopes of the respective circumsporozoite (cs) proteins. by using a two-site immunoradiometric assay, it was determined that all the parasite isolates of a given species react with a single monoclonal antibody, indicating the presence of a common repeated epitope. polyacrylamide gel electr ... | 1985 | 2411813 |
| circumsporozoite protein of plasmodium vivax: gene cloning and characterization of the immunodominant epitope. | the gene encoding the circumsporozoite (cs) protein of the human malaria parasite plasmodium vivax has been cloned. the deduced sequence of the protein consists of 373 amino acids with a central region of 19 tandem repeats of the nonapeptide asp-arg-ala-asp/ala-gly-gln-pro-ala-gly. a synthetic 18-amino acid peptide containing two tandem repeats binds to a monoclonal antibody directed to the cs protein of plasmodium vivax and inhibits the interaction of this antibody with the native protein in sp ... | 1985 | 2414847 |
| sequence of the immunodominant epitope for the surface protein on sporozoites of plasmodium vivax. | plasmodium vivax is one of the four malaria parasites that cause disease in humans. the structure of the immunodominant repeating peptide of the circumsporozoite (cs) protein of p. vivax was determined. a fragment of p. vivax dna that encodes this tandemly repeating epitope was isolated by use of an oligonucleotide probe whose sequence is thought to be conserved in cs protein genes. dna sequence analysis of the p. vivax clone indicates that the cs repeat is nine amino acids in length (gly-asp-ar ... | 1985 | 2416057 |
| laboratory diagnosis of malaria. | 1985 | 2417946 | |
| identification of plasmodium vivax sporozoites in mosquitoes using an enzyme-linked immunosorbent assay. | a sandwich enzyme-linked immunosorbent assay (elisa) for identifying plasmodium vivax sporozoites in mosquitoes is described. monoclonal antibodies produced against thailand p. vivax sporozoites were used in an elisa to detect and identify homologous sporozoites of southeast asian, mexican and north korean origin in extracts of frozen or dried infected mosquitoes. the assay was sensitive enough to detect 1 infected mosquito in a pool of 20 insects or 125-250 sporozoites per 30 microliter of mosq ... | 1985 | 2422965 |
| further studies on the antigenic diversity of the circumsporozoite proteins of the plasmodium cynomolgi complex. | the circumsporozoite (cs) proteins of strains of the plasmodium cynomolgi complex have been examined using antisporozoite monoclonal antibodies (mab) in various immunologic assays. we found extensive antigenic diversity in the repeating immunodominant epitope of the cs proteins of the various strains. based on the antigenicity and the electrophoretic mobility of their cs protein, the 11 strains that we examined can be placed in 7 distinct groups. our data also indicate homology between the immun ... | 1986 | 2422969 |
| [malaria prevention. chemotherapy and immune prophylaxis. 3. immune response of infected organism. perspectives of malaria prevention]. | 1986 | 2423092 | |
| development of a sporozoite malaria vaccine. | 1986 | 2425647 | |
| evolution of the immunodominant domain of the circumsporozoite protein gene from plasmodium vivax. implications for vaccines. | recent work directed toward the development of a malarial vaccine has focused on the identification and production of the immunodominant repeating peptide of the circumsporozoite protein of the human malaria parasites as an antigen. an important factor which relates to the usefulness of this antigen in a vaccine is the rate at which the molecule changes in sequence. we have determined the sequence and arrangement of the repeating epitope of the circumsporozoite protein gene from a plasmodium viv ... | 1987 | 2437120 |
| development of immunity in natural plasmodium falciparum malaria: antibodies to the falciparum sporozoite vaccine 1 antigen (r32tet32). | antibodies that reacted with a candidate sporozoite vaccine antigen (r32tet32) were found in 20 of 21 patients treated for acute infection with plasmodium falciparum and monitored longitudinally over 67 days. r32tet32 contains 32 tandem copies of a tetrapeptide sequence that constitutes the immunodominant epitope of the circumsporozoite surface protein. the magnitude of the antibody response varied considerably among individuals and appeared to be independent of the number of previous clinical i ... | 1987 | 2439533 |
| clinical profile of malaria in children--a prospective study from aligarh (n. india). | in a prospective, hospital-based study in north india, malaria accounted for 1.5% of paediatric outpatient attendances during 1 year. a marked increase in the prevalence of malaria was noted during the post-monsoon months. plasmodium falciparum was the causative species in 44.4% of cases, contrary to previous reports of low prevalence of this parasite in the area. pyrexia with or without chills or rigor, vomiting, pallor and hepatosplenomegaly were the common presenting clinical features. spleni ... | 1987 | 2441656 |
| antigenic analysis of the repeat domain of the circumsporozoite protein of plasmodium vivax. | in the present study we analyzed the fine specificity of mouse monoclonal and human polyclonal antibodies directed against the repeat domain of the circumsporozoite (cs) protein of the human malaria parasite, plasmodium vivax. five synthetic peptides, representing monomeric and dimeric repeats of this malarial antigen, were assayed for their capacity to inhibit the binding of these antibodies to a yeast-derived recombinant cs protein. the results revealed the existence of at least two distinct r ... | 1987 | 2442254 |
| a new human duffy blood group specificity defined by a murine monoclonal antibody. immunogenetics and association with susceptibility to plasmodium vivax. | a new duffy specificity, fy6, defined by a murine monoclonal antibody of the igg1 kappa class, is related to susceptibility to malarial invasion. in humans, fy6 is present on the red cells of all persons except those of the fy(a-b-) type, a distribution resembling that of fy3. however proteolytic enzyme treatment of red cells enhances the reactivity of fy3, whereas fy6, like fya and fyb, is susceptible to degradation by this process. the number of fy6 sites on human red cells was found to be 12, ... | 1987 | 2442291 |
| proteosome-lipopeptide vaccines: enhancement of immunogenicity for malaria cs peptides. | proteosomes are hydrophobic, membranous, multimolecular preparations of meningococcal outer membrane proteins that are also b cell mitogens. these characteristics suggested that proteosomes may serve as carrier proteins and adjuvants to enhance peptide immunogenicity. although high titers of malaria circumsporozoite (cs) antibodies protect against malaria, vaccines thus far tested in humans have been insufficiently immunogenic to be clinically useful. here it is shown that synthetic cs peptides ... | 1988 | 2452484 |
| characterization of cross-reactive blood-stage antigens of the plasmodium cynomolgi complex using anti-plasmodium vivax monoclonal antibodies. | five out of 18 monoclonal antibodies (moab's) produced against blood stages of a brazilian (belem) strain of plasmodium vivax were shown to cross-react with all of the 11 strains of the p. cynomolgi complex that were assayed. the 5 moab's produced 3 different patterns of immunofluorescence, identical for both p. vivax and p. cynomolgi. three of these moab's appeared to react with antigens associated with the cytoplasm or membranes of infected erythrocytes. by western blot analysis, 2 of these 3 ... | 1988 | 2454311 |
| the use of dextran as a blocking agent on nitrocellulose membrane in the analysis of sporozoite antigens of plasmodium vivax. | dextran (molecular weight, 71,200) has been found to block the unbound sites of the nitrocellulose membrane, to which antigens have been electroblotted from acrylamide gel, for use in assaying monoclonal antibodies. the use of polysaccharide as a blocking agent allows the antigens on the nitrocellulose membrane to be digested with pronase and subsequently reacted with monoclonal antibodies. sporozoite antigens of plasmodium vivax, after being digested with pronase, completely lost their antigeni ... | 1988 | 2464018 |
| in vitro evaluation of the role of the duffy blood group in erythrocyte invasion by plasmodium vivax. | a short-term in vitro culture system that allows for significant re-invasion of target erythrocytes by plasmodium vivax was used to study the role of the duffy blood group antigen as a ligand for merozoite invasion by this human malaria species. using human duffy-positive and -negative erythrocytes, various primate erythrocytes, enzymatic modification of erythrocytes, and mab that defines a new duffy determinant (fy6) we conclude that the erythrocyte glycoprotein carrying duffy determinants is r ... | 1989 | 2469769 |
| cross-reacting antigens to pc96, a protective antigen of plasmodium chabaudi, in p. falciparum, p. vivax, and p. cynomolgi. | mice can be partially protected against plasmodium chabaudi by immunization with the antigen pc96, isolated from the erythrocyte membranes of infected mice. we used a pc96 specific monoclonal antibody to identify antigens which cross-react with pc96 in p. falciparum, p. vivax, and p. cynomologi. the cross-reactive molecules are antigens of mr 155,000 in p. falciparum, mr 220,000 in p. cynomologi. they are located in the surface membranes of infected erythrocytes. pc96 is characterized by immunoe ... | 1989 | 2472747 |
| association between hla type and antibody response to malaria sporozoite and gametocyte epitopes is not evident in immune papua new guineans. | hla-a,b,c and dr types were determined for 46 adults living in the madang area of papua new guinea. sera from these individuals were tested by elisa for antibodies against: (i) sonicated schizont extract of plasmodium falciparum; (ii) circumsporozoite repeat regions of p. falciparum and p. vivax; and (iii) epitopes on the 230 and 48/45 kd gametocyte antigens of p. falciparum. all sera were from highly immune individuals and reacted strongly to the schizont antigen. the proportions responding to ... | 1989 | 2482146 |
| [results of the use of a therapeutic protocol for plasmodium vivax for 5 days in 3 municipalities of the são luís island, state of maranhao, brazil]. | a uniform therapeutic schedule of chloroquine 1500mg (three days) and primaquine 75mg (adult 15mg x 5 days) was used in 1232 patients suffering from malaria due to plasmodium vivax occurring in island of são luis maranhão state in the period between january of 1984 and december 1985. of the cases, 499 (40.5%) concluded treatment, and of these 448 were cured. fifty one patients who relapsed responded to a second course of the treatment. | 1989 | 2486524 |
| effects of immigration on the prevalence of malaria in rural areas of the amazon basin of brazil. | epidemiological studies were conducted on malaria in three rural areas of the amazon basin in the state of rondônia: the town of costa marques, forte principe da beira (fort), and an immigrant settlement in the nearby forest. these studies were instituted to document the malaria problem and to describe the role of immigration on its distribution and prevalence. hospital records in the town show that the number of malaria cases increased five fold from 1983 to 1987 and that the predominant malari ... | 1989 | 2487445 |
| the malaria epidemic in antananarivo observed from pediatric service "a" of the befelatanana general hospital. | a recent malaria epidemic striking antananarivo, the capital city of madagascar, is shown from hospital records of pediatric service "a" of the befelatanana general hospital. from 1980 to 1988 malaria cases in this hospital service increased from 0.9% to 14.4% of all admissions (on average 1785 per year). the unexpected expansion is observed in 1984, 1985 and 1986 and since that time malaria has apparently maintained a stable endemic level. malaria mortality as a proportion of general mortality ... | 1989 | 2487897 |
| [malaria. experience at a general hospital]. | general hospitals should not ignore tropical diseases, even if they are not directly concerned with them. in our area, 3 and 6 instances of malaria have been diagnosed per year, 13 cases having been observed during the last 3 years. prognosis is related with the quickness in achieving the diagnosis after the onset of symptoms; in our series it ranged from 4 days and one month. the outcome was good in all cases. to keep a reasonable good suspicion level, it should be remembered that the latency p ... | 1989 | 2490697 |
| [imported malaria: a clinical and epidemiological description of 49 cases]. | malaria is the most common protozoan infection in the world. in 1964, it was considered eradicated in our country, all the new cases being declared as imported, the present migratory and tourism factors obviously having increased the incidence. we analyzed 49 cases of imported malaria diagnosed at "hospital de mar" in barcelona between 1976 and 1987. 14 patients were emigrants from endemic areas. africa as the continent (73.4%), and equatorial guinea as the country (44.8%) being the geographical ... | 1989 | 2491046 |
| [a case of plasmodium vivax malaria complicated with pancytopenia due to hypoplasia of the bone marrow]. | the patient is a 39 year-old japanese male who had traveled to southeast asia from march 14, 1987 and returned on april 2. on april 3 and 5, he had a high fever with chills and he was admitted to our hospital. despite initial treatment with antibiotics, a high fever over 39 degrees c appeared with a 48 hour periodicity. on the 8th day after admission, malarial parasites were identified on the peripheral blood smear after repeated trials. combined with a raised serum antibody titer, plasmodium vi ... | 1989 | 2509594 |
| [diagnosis and prevention of malaria]. | the authors analyze 36 cases of malaria, mainly imported. it was noted that local cases of malaria appear against the background of an increase of the incidence of imported malaria. the authors stress the fact of defects of primary diagnosis of malaria, the possibility of vaccinated cases and pathogen carrier state. the tactics of chemoprophylaxis of malaria is discussed. | 1989 | 2532808 |
| indigestion or infection? unusual presentations of malaria in general practice. | two cases of vivax malaria which presented atypically as abdominal pain are described. they highlight the need to consider malaria in the differential diagnosis of any acute febrile illness in a patient returning from an endemic malarial area. | 1989 | 2556521 |
| rapid, sensitive diagnosis of malaria based on ribosomal rna. | a system for the sensitive and accurate diagnosis of all four species of malaria parasite that are pathogenic in man has been developed. it involves hybridisation of oligonucleotides complementary to species-specific regions of the rna of the parasite small ribosomal subunit followed by autoradiography. the method retains its specificity even under conditions of very low stringency similar to those that will occur in field diagnosis. direct application of treated blood to nylon is possible and c ... | 1989 | 2567370 |
| plasmodium vivax resistance to chloroquine? | two soldiers continued weekly prophylaxis with 300 mg chloroquine base on their return to australia from papua new guinea but were not protected against plasmodium vivax malaria. both had symptoms and parasitaemia although plasma concentrations of chloroquine were considerably higher than those regarded as adequate for suppression of vivax malaria. parasitaemia did not clear after one of the patients was treated with 600 mg chloroquine base. the results suggest the emergence of strains of p viva ... | 1989 | 2572903 |
| chloroquine-resistant plasmodium vivax. | 1989 | 2574333 | |
| [infective complications of the central nervous system (cns) in addicts to parenterally administered drugs]. | given the high rate of infection by hiv in the apad in our country, the description of localized infectious problems in the cns secondary to drug-addiction should always take into account opportunistic infections or tumours occurring there. the initial clinical evaluation should highlight or rule out the presence of clinical indications (specially polyadenia and oral candidiasis) which suggest a clinical condition of immunodepression. septic embolization due to bacteremia and fungemia is common ... | 1989 | 2576906 |
| review of 40 children with imported malaria. | forty cases of imported malaria (1978 to 1988) are reviewed and management principles are discussed. all 15 cases of plasmodium falciparum malaria were acquired in africa, 5 of which were probably chloroquine-resistant. most cases of plasmodium vivax (80%) were acquired on the indian subcontinent, including 2 cases of congenital malaria. six children developed p. falciparum malaria despite chemoprophylaxis. all children had a history of fever, usually with other influenza-like symptoms. two-thir ... | 1989 | 2594448 |
| diffuse lung uptake of technetium-99m sulfur colloid in malaria. | diffuse lung accumulation of colloid was seen on liver-spleen imaging in a patient during the acute stage of vivax malaria. a repeat study was performed following successful therapy and showed complete disappearance of lung uptake. possible mechanisms for this unusual observation are discussed, with the conclusion that this phenomenon is probably related to increased reticuloendothelial system activity, due to a malaria-induced increase in the pulmonary macrophages. | 1989 | 2642952 |
| uninfected erythrocytes form "rosettes" around plasmodium falciparum infected erythrocytes. | the human malaria parasite, p. falciparum, exhibits cytoadherence properties whereby infected erythrocytes containing mature parasite stages bind to endothelial cells both in vivo and in vitro. another property of cytoadherence, "rosetting," or the binding of uninfected erythrocytes around an infected erythrocyte, has been demonstrated with a simian malaria parasite p. fragile which is sequestered in vivo in its natural host, macaca sinica. in the present study we demonstrate that rosetting occu ... | 1989 | 2645800 |
| partial sequence of the asexually expressed su rrna gene of plasmodium vivax. | 1989 | 2648332 | |
| [congenital malaria in a twin]. | congenital malaria is rare even in endemic areas. it is even rarer in a single twin. when this was presented in a clinical case, the diagnosis was checked for the presence of plasmodium vivax in peripheral smears and it was treated with chloroquine as the selected drug. the twin brother never presented clinical manifestations, either from the laboratory or the illness. we comment on the factors that facilitate transplacental transmission. | 1989 | 2653361 |
| immunization of saimiri sciureus boliviensis with recombinant vaccines based on the circumsporozoite protein of plasmodium vivax. | we report a trial in squirrel monkeys of 2 recombinant plasmodium vivax malaria vaccine candidates based on the circumsporozoite (cs) protein. one recombinant (nsl81v20), produced in escherichia coli, contains the repeat region of the cs protein. the other (vivax-1) recombinant is yeast-derived and contains the entire repeat domain and part of the surrounding n-terminal and c-terminal regions. both antigens were administered with alum and muramyl tripeptide as adjuvants. no formulations caused t ... | 1989 | 2658634 |
| plasmodium vivax: in vitro development of exoerythrocytic stages in squirrel monkey hepatocytes and inhibition by an anti-p. cynomolgi monoclonal antibody. | 1989 | 2659376 | |
| erythrocyte invasion by the malarial merozoite: recent advances. | 1989 | 2659377 | |
| dyserythropoiesis and ineffective erythropoiesis in plasmodium vivax malaria. | nine thai adults with p. vivax malaria were investigated. light and electron microscope studies of marrow aspirates revealed morphological evidence of dyserythropoiesis in six of them. dyserythropoiesis was most marked in the four most anaemic patients. in these four patients the electron microscope also revealed the presence of erythroblasts at various stages of degradation within the cytoplasm of macrophages. neither the dyserythropoiesis nor the ineffective erythropoiesis could be attributed ... | 1989 | 2660903 |
| increased ovalocytic red cells and their low parasitemia in malaria infected subjects. | ovalocytic red blood cells were significantly increased in the peripheral blood films of patients infected with p. falciparum (mean +/- s.d. = 6.3 +/- 8.4%) and p. vivax (8.3 +/- 14.0%), whereas, there was only 0.6 +/- 0.4 per cent ovalocytes in normal individuals. per cent parasitemia of ovalocytes counted at least 100 ovalocytes of the blood films of malaria infected individuals was significantly reduced when compared with that of discocytes which revealed at least 100 discocytes in the same b ... | 1989 | 2661709 |
| [therapy and prevention of malaria]. | malaria is still, in spite of intensive efforts to reduce its transmission, the most serious and widespread protozoal infection in man. more than 100 million people suffer of malaria each year and one million, mostly children, die for it. widespread resistance of p. falciparum to drugs, especially 4-aminoquinoline, has been progressing to such a speed in many endemic malarious areas that therapy and prophylaxis procedures have been changing and new drugs or associations of them have been introdu ... | 1989 | 2661957 |
| low response of colombian strains of plasmodium vivax to classical antimalarial therapy. | this report describes 11 cases of plasmodium vivax infection of colombian origin that relapsed 49-166 days following treatment with chloroquine or amodiquine (1.5 g in 3 days) plus primaquine (15 mg daily for 14 days) a regimen widely used to effect radical cure of infections with this parasite. relapses occurred under conditions that precluded reinfection. the fact that most of the relapses occurred within the last two years suggest that p. vivax drug resistance may be developing in colombia an ... | 1989 | 2662351 |
| mixed falciparum and vivax malaria in canadian travellers. | 1989 | 2663130 | |
| differential antibody responses to plasmodium falciparum and p. vivax circumsporozoite proteins in a human population. | papua new guineans exposed to hyperendemic malaria in the madang area showed different antibody responses to plasmodium falciparum and plasmodium vivax sporozoites despite comparable entomological inoculation rates. although there was a significant trend of increasing prevalence of anti-p. falciparum circumsporozoite (cs) protein immunoglobulin g (igg) with age, there was no significant increase in the antibody units of igg recognizing p. falciparum cs proteins. antibodies recognizing p. vivax c ... | 1989 | 2666443 |
| elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated plasmodium falciparum malaria. | tumor necrosis factor alpha (tnf-alpha) has been implicated in the pathology of experimental malaria. to establish its relevance to human malaria, we studied serum levels of two monocyte-derived cytokines, tnf-alpha and interleukin-6 (il-6), as well as of the lymphocyte-derived mediator interferon gamma (ifn-gamma) in patients with malaria before and during antiparasitic treatment. | 1989 | 2667356 |
| purification and characterization of an erythrocyte membrane protein complex carrying duffy blood group antigenicity. possible receptor for plasmodium vivax and plasmodium knowlesi malaria parasite. | a murine monoclonal antibody, named anti-fy6, which agglutinates all human red cells except those of fy(a-b) phenotype was used for purification and characterization of duffy antigens. duffy antigens are multimeric red cell membrane proteins composed of different subunits of which only one, designated pd protein, reacts in immunoblots with the murine monoclonal antibody anti-fy6. affinity-purified detergent-soluble antigen-antibody complex obtained from red cells, surface-labeled with 125i yield ... | 1989 | 2668273 |
| [malaria in guiana. i. general status of the endemic]. | before 1949 malaria was highly prevalent in the whole territory of french guiana. when malaria control based on house-spraying and drug prophylaxis was implemented in 1950 the disease sharply dropped below 20 cases per year. since 1976 despite vector control malaria is rising again. in 1987, 3,269 cases have been notified giving an incidence of 37.6 per thousand for the whole country population; only four deaths were recorded. all the age groups were concerned but the transmission was restricted ... | 1989 | 2670292 |
| [malaria in guiana. ii. the characteristics of different foci and antimalarial control]. | in french guiana, the distribution of malaria in foci inhabited by quite different ethnic groups calls for specific studies. along the oyapock on the brasilian border and along the litani on the surinam border, incidence among american indians and creoles ranges from 300 and 900 per thousand; plasmodium falciparum accounts for 65% and p. vivax for 35%. along the middle and lower maroni on the surinam border, the boni and ndjukas negroes move freely through the frontier and since the civil strife ... | 1989 | 2670293 |
| [an epidemiological study of the residual vivax malaria cases in huanghuai plain]. | in order to get more knowledge of the epidemiological characteristics of the residual cases of vivax malaria in huanghuai plain at the present time, a case-control study was carried out from march to may, 1986 in zhoukou prefecture, henan province and in xuzhou city, jiangsu province. in both areas, the incidence of vivax malaria in 1985 was lower than 1%. the data were analyzed with the conditional logistic multi-regression model and calculated by using apple ii microcomputer. all the malaria c ... | 1989 | 2670310 |
| [studies on the variability of incubation period of vivax malaria following mosquito biting]. | from september 1985 to may 1987, 30 people were experimentally infected by anopheles sinensis infected with plasmodium vivax isolated from northwestern part of hunan province. the findings displayed in graphs demonstrate that the incubation period was variably depended on the number of infective mosquitoes used in the experiment. the short incubation period of 15.8 +/- 1.9d was frequently observed in 6 persons bitten by 10 infected mosquitoes. however, when one mosquito was allowed to feed on ea ... | 1989 | 2670311 |
| micro test for assaying sensitivity of plasmodium vivax in vitro. | a modified rieckmann test was developed for assessing chloroquine sensitivity of plasmodium vivax strains. this test envisages the evaluation of parasite growth with different concentrations of the drug and its comparison with controls, at the end of a 48-hour experimental period. using this test, 16 strains were assessed for their chloroquine sensitivity. twelve strains were found to be sensitive, and 4 were resistant to chloroquine. | 1989 | 2670480 |
| geographical-historical remarks on malaria in czechoslovakia. | 1989 | 2670674 | |
| evolution of the levels of soluble interleukin-2 receptors during plasmodium falciparum and p. vivax malaria. | increased levels of soluble interleukin-2 receptors (il-2r) in serum were observed in both plasmodium falciparum- and p. vivax-infected individuals compared with nonparasitemic subjects. clinical symptoms of p. falciparum malaria were associated with higher levels of soluble il-2r. temporal evolution in serum of il-2r during the course of a malaria attack mimicked the kinetics of soluble il-2r under experimental conditions. | 1989 | 2671038 |
| comparative morphology of human and animal malaria parasites. i. host-parasite interface. | human and animal malaria parasites (plasmodium falciparum, p. malariae, p. vivax, p. berghei, p. gallinaceum) were studied using special fixation and standardized methods, with special attention to their effects on host cells. morphological alterations induced by the parasites in infected erythrocytes included knobs, invaginations, and caveola-vesicle complexes on the surface of the host cell and clefts, microvesicles, and small vesicles in the cytoplasm of the infected erythrocytes. for p. mala ... | 1989 | 2671984 |
| circumsporozoite protein heterogeneity in the human malaria parasite plasmodium vivax. | phenotypic heterogeneity in the repetitive portion of a human malaria circumsporozoite (cs) protein, a major target of candidate vaccines, has been found. over 14% of clinical cases of uncomplicated plasmodium vivax malaria at two sites in western thailand produced sporozoites immunologically distinct from previously characterized examples of the species. monoclonal antibodies to the cs protein of other p. vivax isolates and to other species of human and simian malarias did not bind to these non ... | 1989 | 2672336 |
| development of in vitro microtest for the assessment of plasmodium vivax sensitivity to chloroquine. | an in vitro microtest to assess p. vivax sensitivity to chloroquine has been developed using a medium mixture which contained rpmi, waymouth (gibco) and 15% (vol/vol) human serum group ab. the rate of success was highest in samples which were not washed by centrifugation before culturing in microtest plates predosed with varying concentrations of chloroquine. evaluation of the effective concentration of chloroquine using a program for probit analysis of log dose/response test proved superior to ... | 1989 | 2672367 |
| [to explore the principal vector of malaria by using vectorial capacity]. | this paper reported the vectorial capacity of various anopheles in a tertian malaria infectious area for the period of 1980-1982. the ecological data of various anopheles, which used to take the account into vectorial capacity, were collected in the same manner. we consider that whatever species of anopheles possessing the biggest vectorial capacity, should also be probably the principal vector in that area. 13 species of anopheles had been found in the investigation region but only four species ... | 1989 | 2673529 |
| [the malariologic situation in the yemen arab republic]. | the yemen arab republic is situated in the southwest of the arabian peninsula. from the malariological point of view it belongs to the ethiopian area. malaria is one of the most common diseases in the yar. malaria cases in the country are registered all over the year. the main disease vectors are an. arabiensis, an. sergenti, an. culicifacies. falciparum malaria cases are much more frequent than those of 3- and 4-days malaria. the number of registered malaria cases increases annually. in spite o ... | 1989 | 2674641 |
| plasmodium vivax: merozoite antigens, the duffy blood group, and erythrocyte invasion. | 1989 | 2675110 | |
| fansimef in the treatment of malaria. | 1989 | 2675819 | |
| mixed falciparum and vivax malaria in canadian travellers [correction]. | 1989 | 2676124 | |
| efficacy of 5 day radical treatment of primaquine in plasmodium vivax cases at the bhel industrial complex, hardwar (u.p.). | studies on 725 p. vivax infected patients at the bharat heavy electricals ltd. produced 6.9 per cent relapse rate after administration of radical treatment of primaquine / 15 mg daily for 5 days as followed under the national malaria eradication programme. maximum relapses were recorded in a female patient in spite of repeated radical treatment. | 1989 | 2676618 |
| [malaria in this day and age?]. | 1989 | 2677792 | |
| recombinant subunit vaccines from yeast. | 1989 | 2679931 | |
| [quantitative study on transmission of malaria by anopheles kunmingensis]. | from july to august 1987, a quantitative study on the vector potential of an. kunmingensis (sp. nov.) in comparison with an. sinensis was carried out in nine malaria endemic villages of tengchong county of western yunnan. all the villages contained only three anopheles species: an. kunmingensis, an. sinensis and an. maculatus, among which an. kunmingensis accounted for 77% of 14,871 anopheline mosquitoes collected inside the houses and cowsheds. adult density, man-biting rate, human blood index, ... | 1989 | 2680151 |
| epidemiologic significance of immunity in vivax malaria. | 1989 | 2680552 | |
| plasmodium vivax interaction with the human duffy blood group glycoprotein: identification of a parasite receptor-like protein. | the interaction between merozoites of the human pathogen, plasmodium vivax, and the duffy blood group glycoprotein on the surface of human erythrocytes is essential for the invasion of erythrocytes and the survival of the parasite. we have identified a p. vivax protein of 135 to 140 kda which binds with receptor-like specificity to the human duffy blood group glycoprotein. this interaction can be specifically inhibited by purified duffy glycoprotein and by pretreating erythrocytes with a monoclo ... | 1989 | 2680568 |
| [a case of plasmodium vivax malaria]. | a case of malaria caused by plasmodium vivax is reported in order to underline the importance of correct pharmacological prophylaxis and meticulous anamnestic and epidemiological investigations. | 1989 | 2682378 |
| malaria in adult outpatients at goroka hospital during 1986. | of 206 adult outpatients attending goroka hospital with suspected malaria during 1986, 40.3% had blood slides positive for malaria (28.2% plasmodium falciparum, 13.6% p. vivax and 1.9% p. malariae). parasite densities and proportions of cases with gametocytes were higher than observed in endemic regions. acquisition of infection during recent coastal travel was implicated in the majority of cases (86%). 6 out of 13 gametocyte carriers tested were infectious to anopheles farauti mosquitos. anti-m ... | 1989 | 2683479 |
| [experimental studies on the incubation period and relapse patterns in vivax malaria in west hunan]. | the paper reports on some biological characteristics of plasmodium vivax isolated from cili county of hunan province. 27 volunteers inoculated with sporozoites were observed for 1.5 to 2 years. treatment with chloroquine 1.5g base for 3 days was initiated on the first day of the primary attack and of each relapse. the data indicate that the first latent period in 13 cases developing malaria after short incubation period is very long, being 243.4 (191-297) days; however it is always short, being ... | 1989 | 2686859 |
| [field observation on the relapse pattern in patients naturally infected with vivax malaria from spring to autumn seasons in cili county, hunan province]. | 215 patients of vivax malaria were treated with chloroquine phosphate alone at the dose of 1.5g for three days from april 1986 to october 1987 in cili county in the northwest part of hunan province. among them, 58 cases relapsed, the relapse rate being 27.0%. in patients admitted in april and may, as judged from the interval between treatment and the first relapse, the latent period was short, between 60.8d and 63.5d. on the contrary, when chloroquine treatment was given in august and september, ... | 1989 | 2686860 |
| cerebral malaria by plasmodium vivax. | 1989 | 2687230 | |
| plasmodium vivax malaria presenting with urticaria. | 1989 | 2687831 | |
| imported malaria in trinidad and tobago, w.i. (1968-1986). | malaria surveillance was conducted by the insect vector control division, ministry of health, to determine the number of imported cases of malaria which entered trinidad and tobago from 1968 to 1986. a total of 84 cases of imported malaria was detected; in 44 the agent was plasmodium falciparum, in 25 p. vivax, in 11 p. malariae, in one p. ovale, and three were mixed. the monthly incidence of malaria showed that july and august accounted for 41% of all imported malaria cases. most malaria cases ... | 1989 | 2690758 |
| renal function in acute malaria in children. | tests for renal function were performed in 75 smear positive children with acute malaria together with 10 control children. plasmodium vivax and plasmodium falciparum accounted for 52 and 46 per cent cases, respectively. renal impairment in the form of decreased endogenous creatine clearance (less than 65 ml/min/m2) was noted in 36 of the 75 children with malaria. plasmodium falciparum was responsible for 66 per cent and p. vivax accounted for 30 per cent cases of renal impairment. plasmodium fa ... | 1989 | 2691710 |
| two cases of mefloquine resistant malaria in thailand. | 1989 | 2692218 | |
| plasmodium vivax: enzyme polymorphism in isolates of indian origin. | 185 isolates of plasmodium vivax were collected from patients visiting the malaria clinic run by the national malaria eradication programme, delhi, india. percoll gradient centrifugation was used to concentrate p. vivax parasites from 0.4 to 0.5 ml of blood collected by finger prick. the parasite concentrate from each isolate was electrophoretically analysed for lactate dehydrogenase (ldh), nadp-dependent glutamate dehydrogenase (gdh), glucose phosphate isomerase (gpi) and adenosine deaminase (a ... | 1989 | 2692226 |
| an unusual case of vivax malaria. | 1989 | 2693449 | |
| current trends in malaria in britain. | malaria is already present in britain with an average of 1843 cases reported annually in the last decade. the vast majority are imported cases who have acquired the infection elsewhere but have become ill in the united kingdom. however, minute numbers are acquired either congenitally (transplacentally) from their infected (but often asymptomatic) mothers; or by blood transfusion, though this is almost wholly prevented now; or from mosquitoes, infected with malaria, which have succeeded in stowin ... | 1989 | 2693730 |
| clindamycin is effective against plasmodium falciparum but not against p. vivax in mixed infections. | 1989 | 2694469 | |
| the interrelationship of plasmodium falciparum and p. vivax in the punjab. | analysis of data obtained from giemsa-stained blood films from patients with mixed plasmodium vivax and p. falciparum parasitaemias seen in outpatient clinics held over 20 consecutive months in 4 villages in the pakistani punjab suggest that infections with p. falciparum and p. vivax were independent of each other. there was no evidence to support the hypothesis that p. falciparum suppressed p. vivax. a likely explanation for the seasonal variation in species parasitaemia rates in the punjab is ... | 1989 | 2694481 |
| clinical studies on treatment of cerebral malaria with artemether and mefloquine. | 1989 | 2694488 | |
| electrophoretic variants of enzymes in isolates of plasmodium falciparum, p. malariae and p. vivax from thailand. | a new electrophoretic variant of glucose phosphate isomerase (gpi), which we now denote gpi-3, has been found in isolates of plasmodium falciparum from 6 patients, all of whom acquired the infection in the same region (in or near prachinburi province) of thailand. in other regions, from which 453 isolates have been tested, only gpi-1 and/or gpi-2 have been found. two isolates of p. malariae from patients at kanchanaburi showed a band of gpi activity on cellulose acetate gels at a cathodal positi ... | 1989 | 2694498 |
| a mixed infection of vivax and falciparum malaria apparently resistant to 4-aminoquinoline: a case report. | 1989 | 2694500 | |
| anopheles neivai: a vector of malaria in the pacific lowlands of colombia. | 1989 | 2694501 | |
| coconut milk and the cultivation of plasmodium in vitro. | 1989 | 2694505 | |
| febrile illness in an afghani "freedom fighter". | 1989 | 2695691 | |
| proteosome-hydrophobic 'foot' malaria peptide vaccines for plasmodium falciparum and p. vivax. | the immunogenicity of synthetic peptides representing the repeating portions of circumsporozoite proteins of plasmodium sporozoites was greatly increased by complexing them to proteosomes via hydrophobic moieties added to their amino termini. proteosomes have been used safely in people in the development of meningococcal vaccines and therefore proteosome-peptide vaccines are prime candidates for use against malaria. | 1989 | 2696152 |
| a seroepidemiological study to evaluate the role of passive maternal immunity to malaria in infants. | parasitaemias and loss of natural antibody to plasmodium falciparum were studied in 104 infants in a highly endemic area of papua new guinea. there were 4 cases of congenital infection. most infants lost malaria-specific immunoglobulin g (igg) between 4 and 7 months (median = 21 weeks). 73% of heavy infections developed in infants without detectable antimalarial igg. infections in the presence of antimalarial igg were asymptomatic and had scanty parasitaemias. | 1989 | 2696154 |
| congenital malaria. | 1989 | 2698387 | |
| incrimination of anopheles dirus as a vector of malaria in dibrugarh district, assam. | anopheles nigerrimus, a. vagus, a. dirus, a. karwari and a. kochi were the most abundant species among 12 anopheline species collected during the course of entomological studies carried out from july to september, 1988 in an area endemic for malaria under tengakhat phc of dibrugarh district, assam. sporozoites were detected in the salivary glands of one specimen of a. dirus, peyton & harrison (a. balabacensis) which constituted about 18.11 per cent of the total anopheline collection. | 1989 | 2699591 |
| laboratory diagnosis of malaria infection and its natural history in an urban pocket of hyderabad city. | 1989 | 2699866 | |
| enrichment of plasmodium vivax-infected red blood cells from patients with vivax malaria. | 1987 | 2821630 | |
| trials of mefloquine in vivax and of mefloquine plus 'fansidar' in falciparum malaria. | two randomised double-blind trials were conducted to examine the activity and tolerability of mefloquine alone and in combination with sulfadoxine/pyrimethamine (msp). in one trial mefloquine was compared with chloroquine in 40 patients with plasmodium vivax malaria and in the other one mefloquine was compared with msp in 40 patients with p falciparum malaria. the former trial showed that both a single oral dose of 250 mg mefloquine and a single oral dose of 450 mg chloroquine (base) were highly ... | 1985 | 2858743 |
| malaria treated with emetine or metronidazole. | 1985 | 2863513 | |
| combination of mefloquine with sulfadoxine-pyrimethamine compared with two sulfadoxine-pyrimethamine combinations in malaria chemoprophylaxis. | 1985 | 2863679 | |
| is plasmodium falciparum resistance to chloroquine reversible in absence of drug pressure? | 1986 | 2868179 | |
| endemic malaria in hong kong. | 1986 | 2872446 |