Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| compression arthrodesis of the ankle by triangular external fixation: an improved technique. | in this preliminary report, the authors present a new application of an external tubular fixation system for compression arthrodesis of the ankle. a triangular ankle fusion frame was designed that provides rigid immobilization of the tibiotalar joint, with midfoot control provided by a metatarsal pin. over the past 3 years, the authors have used this device to achieve solid tibiotalar arthrodesis in 12 of 14 patients. the surgical method, including step-by-step construction and application of th ... | 2009 | 2798241 |
| compression arthrodesis of the ankle by triangular external fixation: an improved technique. | in this preliminary report, the authors present a new application of an external tubular fixation system for compression arthrodesis of the ankle. a triangular ankle fusion frame was designed that provides rigid immobilization of the tibiotalar joint, with midfoot control provided by a metatarsal pin. over the past 3 years, the authors have used this device to achieve solid tibiotalar arthrodesis in 12 of 14 patients. the surgical method, including step-by-step construction and application of th ... | 2009 | 2798241 |
| immunization of cattle with the msp-1 surface protein complex induces protection against a structurally variant anaplasma marginale isolate. | the anaplasma marginale surface protein complex msp-1 of the florida isolate is composed of a 105-kilodalton (kda) polypeptide, which bears a neutralization-sensitive epitope, and a 100-kda polypeptide. antigenically similar polypeptides in the okanogan, wash. (washington-o), isolate msp-1 are 86 and 100 kda, respectively. immunization of cattle with florida isolate msp-1 induced antibody titers to both msp-1 polypeptides and protected cattle against homologous and heterologous challenge. | 1989 | 2807542 |
| topically active carbonic anhydrase inhibitors. 1. o-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide. | a series of o-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide (4, l-643,799) was prepared and the potential utility of each series member as a topically active inhibitor of ocular carbonic anhydrase was determined. in vitro studies showed these esters to be substrates for ocular esterases which liberate 4 during corneal translocation. the most interesting series member, 2-sulfamoyl-6-benzothiazolyl 2,2-dimethylpropionate (22, l-645,151), acting as a prodrug form of 4, was found to enhan ... | 1989 | 2810337 |
| [combined abdominal injuries]. | 2009 | 2811122 | |
| [treatment of ununited fractures and pseudarthrosis of the distal end of the femur complicated by extension contracture of the knee joint]. | 2009 | 2811131 | |
| [europe 1992: big brother is watching you]. | 2009 | 2812101 | |
| [europe 1992: big brother is watching you]. | 2009 | 2812101 | |
| [written information on prescribed drugs provided by pharmacies]. | 2009 | 2815030 | |
| [written information on prescribed drugs provided by pharmacies]. | 2009 | 2815030 | |
| allograft tolerance induction in adult mice associated with functional deletion of specific ctl precursors. | rejection of h-2 class i bm 1 mutant skin allografts by b6 recipient mice is mediated by a population of cd8+ anti-bm1 cytotoxic t-lymphocytes that produces and consumes its own t helper factor in response to bm1 skin allografts (dual function ctl). previously we have demonstrated that transfusion of allogeneic lymphocytes across an h-2 class i disparity induces specific long-lasting skin allograft survival. we now show that intravenous injection of allogeneic spleen cells across the bm1 mutant ... | 2009 | 2815256 |
| allograft tolerance induction in adult mice associated with functional deletion of specific ctl precursors. | rejection of h-2 class i bm 1 mutant skin allografts by b6 recipient mice is mediated by a population of cd8+ anti-bm1 cytotoxic t-lymphocytes that produces and consumes its own t helper factor in response to bm1 skin allografts (dual function ctl). previously we have demonstrated that transfusion of allogeneic lymphocytes across an h-2 class i disparity induces specific long-lasting skin allograft survival. we now show that intravenous injection of allogeneic spleen cells across the bm1 mutant ... | 2009 | 2815256 |
| risk factors for soft tissue sarcomas in childhood: a case-control study. | a hospital-based case-control study on soft tissue sarcomas (sts) was conducted in 1983-84 in torino and in padova (italy). cases (36 children with rhabdomyosarcoma (rms) and 16 non rms-sts) were compared to 326 controls. histories of parental smoking habits and occupations, parental and children's exposure to ionizing radiation, children's diseases and some other variables were collected through interviews to the relatives attending the child in the hospital. a non statistically significant ass ... | 2008 | 2815346 |
| [a quick and simple method for estimating the oxyhemoglobin dissociation curve]. | the methods currently available for assessing the oxyhaemoglobin dissociation curve parameters are expensive, lengthy, require a large volume of blood, and the results obtained are modified by anaesthetic gases. the equipment required for the method described includes: a microtonometre, microcuvettes, 3 gas bottles containing different oxygen, carbon dioxide and nitrogen mixtures (4.5%, 5.6%, 89.9%; 3.5%, 5.6%, 90.9%; 2.5%, 5.6%, 91.9% respectively), a microxymetre, and a microphmetre. the sampl ... | 2010 | 2817553 |
| interstitial deletion of (17)(p11.2). a microdeletion syndrome. another example. | another example of del (17)(p11.2) in a 3-year-old boy with psychomotor retardation, broad face, midface hypoplasia, prognathism, and behavioural anomalies was diagnosed clinically and confirmed by prometaphase analysis. it seems that this new microdeletion syndrome may not be so rare. | 1989 | 2817780 |
| in vivo pharmacology of ici 198,615: a novel, potent and selective peptide leukotriene antagonist. | the in vivo pharmacology of ici 198,615, a highly potent and selective peptide leukotriene (lt) receptor antagonist, is described. in a conscious guinea pig model, ici 198,615 provided dose-related antagonism of aerosol ltd4-induced dyspnea when administered p.o., i.v. or by aerosol. the pharmacologic half-lives of ici 198,615 by these routes of administration were greater than 16 hr, 68 min and 34 min, respectively. in pulmonary mechanics studies in which the effects of i.v. or aerosol administ ... | 1987 | 2824752 |
| reinfection of guinea pigs with herpes simplex virus type 2: failure to establish a second latent ganglionic infection. | guinea pigs were infected with herpes simplex virus type 2 (hsv 2) and at various times thereafter reinfected at a different site with the same or a different strain of hsv 2. viruses were isolated from infected tissues either from the site of primary or secondary infection or from regional ganglia. viral isolates were characterised by dna fingerprinting using restriction endonucleases capable of differentiating between the virus strains used. the second infection resulted in a second site of pe ... | 1987 | 2825951 |
| [involvement of arterial vessels in the blood supply to adenomas of the human pituitary, functional implications]. | among 190 human pituitary adenomas investigated, 140 contained arterial blood vessels (nearly 75 percent). in 160 adenomas (prl-, gh-secreting or nonfunctioning tumors) arterial vessels were present in 80 to 90 percent of the cases, whereas in 30 corticotropic adenomas (cushing's disease), 5 only contained arterial vessels. according to data of the literature and to our own findings, such vessels should originate from the anterior pituitary itself or from the surrounding structures (trabecular, ... | 1986 | 2832021 |
| dna probes for the detection of anaplasma centrale and anaplasma marginale. | anaplasmosis can be diagnosed either by immunological techniques or by direct microscopic examination of blood smears. both methods are time-consuming and labour intensive. the use of dna probes in an hybridization assay may simplify the diagnosis of anaplasmosis in cattle and sheep. a genomic dna library of anaplasma centrale was constructed in an expression vector and screened to detect clones containing a. centrale dna. four probes which hybridized to a. centrale and anaplasma marginale dna w ... | 1987 | 2832800 |
| biological activity of 1,25-dihydroxyvitamin d2 and 24-epi-1,25-dihydroxyvitamin d2. | the biological activity of 1,25-dihydroxyvitamin d2 [1,25(oh)2d2] and 24-epi-1,25-dihydroxyvitamin d2 [24-epi-1,25(oh)2d2] has been determined in vitamin d-deficient rats. the biological effectiveness of 1,25(oh)2d2 is equal to that reported previously for 1,25-dihydroxyvitamin d3 [1,25(oh)2d3] (15) in intestinal calcium transport, mineralization of bone, mobilization of bone calcium, and elevation of plasma inorganic phosphorus of rachitic rats. however, 24-epi-1,25(oh)2d2 is at best one-half a ... | 1988 | 2833108 |
| [possibility of the early diagnosis of the suture incompetence of a large intestine anastomosis]. | radionuclide examinations consisting in intraoperative injection of a nonabsorbed radiopharmaceutical preparation into the lumen of adducting portion of the gut were proposed for the detection of incompetence of anastomosis sutures in the early postoperative period. the investigation was performed in 45 patients. complications on the anastomosis were detected in 7 patients: in 5 patients--anastomositis, in 2 patients--incompetence of the anastomosis sutures, the radiopharmaceutical preparation b ... | 2010 | 2836984 |
| isolation and restriction endonuclease cleavage of anaplasma marginale dna in situ in agarose. | bacterial restriction endonucleases were used to produce dna cleavage patterns that could be useful as tools to study the relatedness among anaplasma marginale isolates. bovine erythrocytes infected with a. marginale were lysed, washed, and embedded in agarose. the embedded erythrocytes and bacterial pathogens were partially digested by sequential infiltration of the agarose with acetone, lysozyme, sodium dodecyl sulfate, and proteinase k. the unfragmented genomic dna was left supported and prot ... | 1988 | 2838504 |
| characterization of a cdna clone encoding the calmodulin-binding domain of mouse brain calcineurin. | a cdna clone corresponding to a portion of the catalytic subunit of calmodulin (cam)-dependent phosphoprotein phosphatase (calcineurin) was isolated from a murine brain library by expression vector immunoscreening. a beta-galactosidase fusion protein that reacted on western blots with anti-calcineurin antibodies and biotinylated cam was purified in preparative amounts using cam-sepharose affinity chromatography. partial digestion of the hybrid protein with staphylococcus aureus v-8 protease prod ... | 1988 | 2848250 |
| processing of digestive vacuoles in tetrahymena and the effects of dichloroisoproterenol. | the digestive-lysosomal system in tetrahymena has been extensively studied; however, the various vacuole stages and the existence of a required processing period prior to defecation have not been clearly defined. in this study the presence of such a required processing period and the rate of dv defecation in tetrahymena thermophila were determined. like the cycle in paramecium, a digestive cycle in tetrahymena consisted of two periods: the processing period was 45 min and the defecation period w ... | 2010 | 2859369 |
| [ecto-atpases in leukocytes and its modification by drugs]. | the ecto-atpase is located on the external surface of the plasma membrane of intact cells. the enzyme splits exogeneous atp in the presence of mg2+ into adp and inorganic phosphate. this enzyme has been found on a variety of cells of various species in different activities. in leukocytes sulfhydryl groups are essential for the structure and function of the ecto-atpase. the physiological and biochemical significance of the ecto-atpase for cells remains unclear. drugs may influence ecto-atpase act ... | 1985 | 2859769 |
| truth, trust, and paternalism. | the emphasis on the necessity for fully informed consent in two new books, doctors' dilemmas by m. phillips and j. dawson and whose body is it? by c. faulder, is found to be "lacking in balance" by brewin. the doctor's discretion in dealing with each patient is considered to be the key to determining priorities between paternalism and communication. rigid rules, brewin argues, may not be in the patient's best interest and thus should not be forced on doctors and nurses by "philosophers or expert ... | 2010 | 2863503 |
| therapeutic drug monitoring. | 2010 | 2863512 | |
| [carcinoid of the papilla of vater-somatostatinoma--a case report]. | a 46-year-old woman was referred to our hospital because of liver dysfunction. she had been suffering from right hypochondralgia for two months. on admission, laboratory data indicated extrahepatic cholestasis. both x-ray and endoscopic examinations confirm a submucosal tumor of the papilla of vater, and surgical diagnosis was performed. histologically, the tumor was diagnosed as carcinoid, and a further immunohistochemical study by the pap method using antisomatostatin serum indicated somatosta ... | 2008 | 2874242 |
| [beta-adrenergic blockers]. | 2010 | 2876553 | |
| primary structure and synthesis of a blocked myotropic neuropeptide isolated from the cockroach, leucophaea maderae. | a peptide which stimulates the contractile activity of the cockroach hindgut was isolated from head extracts of the cockroach, leucophaea maderae. the inability of aminopeptidase m to degrade the peptide and the presence of glutamic acid in the hydrolysate suggested n-terminal blocking by pyroglutamic acid. the n-terminal pglu was removed enzymatically and the unblocked fragment was sequenced with an automated gas-phase peptide sequencer. the structure determined (pglu-thr-ser-phe-thr-pro-arg-le ... | 2010 | 2877794 |
| a case of wound botulism. | 2010 | 2882064 | |
| high-performance liquid chromatographic assay for dilevalol in human plasma and urine using a prp-1 column and fluorimetric detection. | a single high-performance liquid chromatographic (hplc) assay for the quantitative determination of dilevalol, the r,r isomer of labetalol, was developed for both plasma and urine. a significantly improved limit of detection for dilevalol in plasma was accomplished by extensive modification of an hplc assay originally developed in our laboratory for labetalol. this simplified method is readily adaptable to urine and represents the first reported hplc assay for the quantitative determination of d ... | 1988 | 2897376 |
| [perspectives in the drug therapy of peptic ulcer]. | 2010 | 2897487 | |
| characterization of sodium carboxymethylcellulose-gelatin complex coacervation by viscosity, turbidity and coacervate wet weight and volume measurements. | a sodium carboxymethylcellulose (scmc) and gelatin coacervation system has been evaluated and characterized and the effects of ph and colloid mixing ratio on the coacervation process investigated. the colloid mixing ratio at which optimum coacervation occurred varied with the coacervation ph. a viscometric investigation of various isohydric scmc-gelatin mixtures was used to predict optimum conditions for complex coacervation. optimum coacervation occurred at ph 3.5 at a scmc-gelatin weight ratio ... | 2010 | 2900300 |
| dopamine-mediated behaviour following chronic treatment with b-ht 920. | following subchronic (5-day) dosing with b-ht 920 (2-amino-6-allyl-5,6,7,8-tetrahydro-4h-thiazolo(4,5-d)azepine (1 mg kg-1 day-1 i.p.) in rats there was a significant increase in both apomorphine-induced motor activity and stereotypy. on continued b-ht 920 treatment, however, the enhancement of apomorphine motor activity faded into insignificance but the increase in stereotypy persisted beyond 15 days. the results are discussed in terms of dopamine autoreceptor tolerance, postsynaptic d2 superse ... | 1988 | 2905000 |
| alpha adrenoceptor subtypes and receptor reserve in human versus canine saphenous vein: sensitivity to blockade by nitroglycerin. | the purpose of this investigation was to determine the subtypes of alpha adrenoceptors present in human saphenous vein and to determine if there is a large receptor reserve for phenylephrine as has been demonstrated in canine saphenous vein. the subtypes of alpha adrenoceptors found in isolated human saphenous vein were determined using selective alpha-1 and alpha-2 adrenoceptor agonists and antagonists. prazosin, a selective alpha-1 antagonist, produced a parallel shift of the concentration res ... | 1988 | 2905005 |
| [prenatal diagnosis of duchenne muscular dystrophy using dna rflp analysis]. | 2010 | 2907413 | |
| intracavernous injection of prostaglandin e1 for the treatment of erectile impotence. | we administered intracavernous injections of 20 micrograms. prostaglandin e1 to 135 patients with impotence, and evaluated the effects and side effects. among 135 patients who underwent intracavernous injection of prostaglandin e1 complete erection was observed in 83 (62 per cent), while incomplete erection was noted in 33 (24 per cent). in both groups the erection was sufficient for sexual intercourse. tumescence without rigidity was noted in 12 patients and no response was obtained in 7. poor ... | 2010 | 2913354 |
| detection and quantitation of anaplasma marginale in carrier cattle by using a nucleic acid probe. | cattle which have recovered from acute infection with anaplasma marginale, a rickettsial hemoparasite of cattle, frequently remain persistently infected with a low-level parasitemia and serve as reservoirs for disease transmission. to fully understand the role of these carriers in disease prevalence and transmission, it is essential that low levels of parasitemia can be accurately detected and quantitated. we have developed a nucleic acid probe, derived from a portion of a gene encoding a 105,00 ... | 1989 | 2915021 |
| [luxatio humeri erecta. a rare form of inferior shoulder dislocation]. | in patients with erect dislocation of the shoulder, the arm is typically locked in an upright position. this rare variant of subglenoid luxation always causes damage to the ligamentous structures of the joint and sometimes additional complications arise from neurovascular lesions. two recent cases are reported here. the mechanism of injury, therapeutic measures and prognosis are discussed. | 2010 | 2916131 |
| glucocorticoid receptor activation in isolated perfused rat hearts. | the formation of unactivated and activated glucocorticoid receptor complexes was studied in intact, isolated, perfused rat hearts in the presence of [3h]triamcinolone acetonide. receptor activation, as quantified by the dna-cellulose-binding assay, began to increase within 30 s of perfusion and reached a final steady-state level (t 1/2 = 4.6 min) with 46% of the steroid-receptor complexes bound to dna-cellulose. with the use of a linear potassium phosphate (kp) gradient (5-400 mm), unactivated r ... | 1989 | 2919654 |
| rigid policies can help a plaintiff's case. | 2010 | 2921027 | |
| quantitation of lactoferrin in odontogenic cyst fluids. | a competitive enzyme linked immunosorbent assay (elisa) method was used to measure the concentration of lactoferrin in fluids from 36 odontogenic keratocysts, 15 dentigerous cysts, and 30 radicular/residual cysts. keratocyst fluids contained significantly higher concentrations of lactoferrin than fluids from the other two types of cyst (p less than 0.001); but the range of values obtained within each group was large. although lactoferrin represents a larger proportion of the total protein in ker ... | 2010 | 2921360 |
| activity of ciprofloxacin against resistant clinical isolates. | the in-vitro activity of ciprofloxacin, a new quinolone derivative, was determined by broth microdilution for 518 clinical isolates. the mics for 90% of the organisms were 2 mg/l for pseudomonas aeruginosa, 8 mg/l for p. maltophilia, 4 mg/l for other pseudomonas spp., 1 mg/l for acinetobacter anitratus, 0.03-0.5 mg/l for differing species of enterobacteriaceae, 2 mg/l for streptococcus faecalis, 0.25 mg/l for coagulase-negative staphylococcus spp. and 2 mg/l for s. aureus. furthermore, on a weig ... | 1986 | 2939048 |
| immunological studies in haemophilic children. | a majority of haemophiliacs who have received large-pool plasma products within the past 5 years have been exposed to the putative agent of the acquired immunodeficiency syndrome (aids)--hiv. it is not known what the risk of infection is among patients in south africa. a study was made of 39 children with congenital coagulation disorders attending the red cross war memorial children's hospital haemophilia clinic. all but 3 had been treated exclusively with small-pool lyophilised cryoprecipitate ... | 1987 | 2953077 |
| transport of light in tissue in photodynamic therapy. | 2010 | 2964653 | |
| [rpo pathway as a possible recombination mechanism of the interaction between dna of transducing phages and the escherichia coli genome]. | the conditions affecting recombination of dnas of transducing lambdoid rifd phages with the chromosome of escherichia coli k-12 reca in the region of homology were studied. in support to the previously obtained data, the int system was shown to take no part in the process. the homologous character of recombination interactions and their dependence on efficiency of transcription were demonstrated. it is therefore suggested that recombination takes the rpo pathway. similar peculiarities were revea ... | 1988 | 2976700 |
| origin of leukemic relapse after bone marrow transplantation detected by restriction fragment length polymorphism. | bone marrow transplantation has become an accepted modality in the treatment of acute leukemia. with this therapy, it is possible to obtain long-term disease-free survival. however, leukemia recurs occasionally. in most cases, leukemic relapse is of recipient origin. there have been several reports, though, of leukemia developing in donor cells. these cases have been limited to instances in which there is an easily identifiable chromosome difference or abnormality, usually a sex chromosome. in t ... | 2010 | 2981254 |
| regulation of galactokinase gene expression in tetrahymena thermophila. ii. identification of 3,4-dihydroxyphenylalanine as a primary effector of adrenergic control of galactokinase expression. | intracellular concentrations of catecholamines were determined in wild-type and mutant tetrahymena thermophila, using the highly sensitive techniques of high-performance liquid chromatography and electro-chemical detection. catecholamines were determined in these cell strains grown under various steady-state conditions, including those which initiate and maintain repression of galactokinase gene expression. wild-type cells grown in defined minimal medium supplemented with 1% glycerol, exhibiting ... | 2010 | 2991271 |
| prevalence of cytomegalovirus antibodies in thai blood donors. | antibodies to cytomegalovirus (cmv) were determined in thai blood donors using the complement fixation (cf) test and enzyme-linked immunosorbent assay (elisa). a total of 203 voluntary blood donors, 181 males and 22 females, who came to the blood bank at siriraj hospital during february 1985, were investigated. their ages ranged from 17 to 53 years (mean 24.3 +/- 6.9). seventy-three out of 156 (46.8%) and 171 out of 203 (84.2%) sera were positive for cmv antibodies as detected by the cf test and ... | 1985 | 3000401 |
| a new method of representing dna sequences which combines ease of visual analysis with machine readability. | a new method of representing dna sequences has been devised which is termed stave projection. compared with other formats for showing the base sequences of dna, this method greatly enhances the ease of visual analysis of the sequences of bases and it is also in a machine readable form. using this method it is possible to identify and annotate all of the functional features found in dna sequences. | 2010 | 3003680 |
| bradykinin stimulates gtp hydrolysis in ng108-15 membranes by a high-affinity, pertussis toxin-insensitive gtpase. | in membranes of neuroblastoma x glioma hybrid (ng108-15) cells, bradykinin (ec50 approximately equal to 5 nm) stimulates gtp hydrolysis by a high-affinity gtpase (km approximately equal to 0.2 microm). the octapeptide, des-arg9-bradykinin, was inactive. stimulation of gtp hydrolysis by bradykinin and an opioid agonist was partially additive. treatment of ng108-15 cells with pertussis toxin, which inactivates ni, eliminated gtpase stimulation by the opioid agonist but not by bradykinin. the data ... | 1986 | 3005034 |
| bradykinin stimulates gtp hydrolysis in ng108-15 membranes by a high-affinity, pertussis toxin-insensitive gtpase. | in membranes of neuroblastoma x glioma hybrid (ng108-15) cells, bradykinin (ec50 approximately equal to 5 nm) stimulates gtp hydrolysis by a high-affinity gtpase (km approximately equal to 0.2 microm). the octapeptide, des-arg9-bradykinin, was inactive. stimulation of gtp hydrolysis by bradykinin and an opioid agonist was partially additive. treatment of ng108-15 cells with pertussis toxin, which inactivates ni, eliminated gtpase stimulation by the opioid agonist but not by bradykinin. the data ... | 1986 | 3005034 |
| long-term culture of human granulocytes and granulocyte progenitor cells. | 1986 | 3008194 | |
| further evidence that a beta-adrenergic mechanism regulates water intake: role of the subfornical organ. | the daily water intake was reduced in rats by subcutaneous administration of propranolol. the fluid intake after 24 h of dehydration in nephrectomized animals was decreased by propranolol. in intact rats diazepam did not modify the postdehydration water intake. propranolol injected into subfornical organ decreased water consumption after 24 h of fluid deprivation but did not change the dipsogenic response to carbachol given in the same structure. these results suggest that a beta-adrenoceptor me ... | 1986 | 3019711 |
| further evidence that a beta-adrenergic mechanism regulates water intake: role of the subfornical organ. | the daily water intake was reduced in rats by subcutaneous administration of propranolol. the fluid intake after 24 h of dehydration in nephrectomized animals was decreased by propranolol. in intact rats diazepam did not modify the postdehydration water intake. propranolol injected into subfornical organ decreased water consumption after 24 h of fluid deprivation but did not change the dipsogenic response to carbachol given in the same structure. these results suggest that a beta-adrenoceptor me ... | 1986 | 3019711 |
| cloning and characterization of the high-affinity camp phosphodiesterase of saccharomyces cerevisiae. | a gene, pde2, has been cloned from the yeast saccharomyces cerevisiae that, when present in high copy, reverses the phenotypic effects of ras2val19, a mutant form of the ras2 gene that renders yeast cells sensitive to heat shock and starvation. it has previously been shown that the ras proteins are potent activators of yeast adenylate cyclase. we report here that pde2 encodes a high-affinity camp phosphodiesterase that shares sequence homology with animal cell phosphodiesterases. these results t ... | 1986 | 3025832 |
| [muscle relaxation with triethylene thiophosphoramide]. | 2011 | 3033839 | |
| double-blind comparison of urapidil and prazosin in the treatment of patients with essential hypertension. | a multicentre double-blind comparative study of urapidil and prazosin was performed in 412 outpatients with mild to moderate essential hypertension. 222 patients were treated by monotherapy (107 on urapidil and 115 on prazosin), and 190 in combination with thiazide diuretics (99 on urapidil and 91 on prazosin). after a 4-week control period on placebo, the patients were randomised for treatment with twice daily urapidil (total of 30-120 mg/day) or 3 times daily prazosin (total of 1.5 to 6 mg/day ... | 2010 | 3042355 |
| prophylactic injection sclerotherapy for esophageal varices: a critical appraisal. | 2010 | 3044915 | |
| [research on the genetic polymorphism of hydroxy metabolism of debrisoquine and its significance]. | 2011 | 3045961 | |
| inhibition of drug metabolism by quinolone antibiotics. | a number of quinolone antibiotics have been found to reduce the hepatic clearance of coadministered drugs such as theophylline. enoxacin appears to be the most potent inhibitor, consistently decreasing theophylline clearance by more than 50%, while a single study suggests a similar degree of inhibition with pipemidic acid. ciprofloxacin and pefloxacin reduce theophylline clearance to a smaller extent (approximately 20 to 30%). however, with ciprofloxacin, larger changes and theophylline toxicity ... | 2005 | 3052987 |
| [the respiratory tract and air pollution]. | 2008 | 3053144 | |
| characterization of mannoproteins from a virulent candida albicans strain and its derived, avirulent strain. | antigenic differences between a wild-type virulent strain of candida albicans 4918 (wt) and its spontaneous avirulent mutant (m-10) were found with crossed-immunoelectrophoresis and western blotting. mannoprotein fractions from yeast and mycelial forms were obtained by affinity chromatography on concanavalin a and analyzed with use of patient sera or sera from rabbits infected with live wt cells and boosted with whole extracts or rabbits immunized with purified wt cell wall preparations. a spike ... | 1988 | 3055210 |
| c-heterochromatin variation and transposition in tumor progression. | 2004 | 3066156 | |
| molecular implications of ph (+) myelodysplastic syndrome. | we report a case of 62-year-old japanese male with a myelodysplastic syndrome (mds) with a philadelphia (ph) chromosome. cytogenetic analysis revealed the bone marrow cells to contain a ph chromosome due to t(?;11;22) (?;q11;q11), as well as -5, -7, +8, -12 and an extra ph, in addition to cells with a normal karyotype. molecular analysis using breakpoint cluster region probes (5' bcr and 3' bcr) did not detect a rearrangement within the bcr dna sequences, indicating that the breakpoint at 22q11 ... | 1988 | 3066168 |
| epidemiological patterns and incidence of bio-, sero- and phage types of vibrio cholerae in hyderabad, india, during 1971-1984. | during 1971-1984 out of 44,762 gastroenteritis cases bacteriologically examined, 4240 (9.5%) vibrio cholerae were isolated in hyderabad, india. out of them 1329 (31.3%) were classical and 2911 (68.7%) were el-tor biotypes. the changeover from classical to el-tor cholera was observed in hyderabad during 1975 and persisted. during this 14 year period four major outbreaks with v. cholerae serogroup o1 ogawa, v. cholerae biotype el-tor serogroup o1 ogawa were observed. phage types 1, 2 and 4 were pr ... | 1988 | 3067503 |
| interaction of magnesium ion, oxygen tension, and temperature in the production of toxic-shock-syndrome toxin-1 by staphylococcus aureus. | 1987 | 3102633 | |
| [immunological studies in hamsters (cricetus auratus) infected with schistosoma mansoni]. | 1986 | 3105038 | |
| [evaluation of the use of parenteral nutrition in chronic and severe radiation enterocolitis]. | the effects of parenteral nutrition in the treatment of patients with severe chronic radiation enterocolitis is not known. we retrospectively studied 19 adult patients who received parenteral nutrition during 8.6 +/- 2.4 months (mean +/- sem), including 6 cases in our home-parenteral nutrition-program. parenteral nutrition was started 49 +/- 12 months after radiation therapy; follow-up after parenteral nutrition was 22 +/- 7 months. indication for parenteral nutrition was malnutrition (weight = ... | 2011 | 3106127 |
| an enzyme linked immunosorbent assay to diagnose babesia bovis infection in cattle. | the optimum gel filtration fraction from lysate of babesia bovis infected erythrocytes was determined for use as an antigen in an elisa to diagnose b. bovis infection in cattle. of four enzyme labels tested, horseradish peroxidase was the most suitable. the assay is both sensitive and specific in detecting antibody for 2-4 years after a single infection. false positive reactions were obtained only with some sera from some anaplasma marginale infected cattle. | 1987 | 3106957 |
| the association of smoking with clinical indicators of altered sex steroids--a study of 50,145 women. | this study was designed to test the association of smoking with four clinically apparent conditions that may be related to altered sex steroids: natural and induced menopause, infertility, oligomenorrhea, and hirsutism. data were obtained from the personal inventories of 50,145 women ages 20-59 years in tops, a weight reduction program. the age-adjusted odds ratios of each condition for heavy smokers compared with nonsmokers were 1.59 for natural menopause, 1.49 for induced menopause, 1.35 for i ... | 2011 | 3108939 |
| multiple myeloma: biological and clinical significance of bone marrow plasma cell labelling index. | 2011 | 3114074 | |
| molecular evolutionary clock. | 2011 | 3125328 | |
| nutritional assessment in a surgical practice. | 2011 | 3131063 | |
| effect of thyroid status and paraventricular area lesions on the release of thyrotropin-releasing hormone and catecholamines into hypophysial portal blood. | trh is a potent stimulator of pituitary tsh release, but its function in the physiological regulation of thyroid activity is still controversial. the purpose of the present study was to investigate trh and catecholamine secretion into hypophysial portal blood of hypothyroid and hyperthyroid rats, and in rats bearing paraventricular area lesions. male rats were made hypothyroid with methimazole (0.05% in drinking water) or hyperthyroid by daily injections with t4 (10 micrograms/100 g bw). untreat ... | 1988 | 3133200 |
| panic disorder, vertigo, and the protirelin (trh) test. | 2011 | 3133685 | |
| tripelennamine enhances buprenorphine-, but not pentazocine-induced hyperactivity in mice. | the opioid agonist-antagonist pentazocine (1-30 mg/kg) and the partial agonist buprenorphine (0.05-0.25 mg/kg) were tested, alone or in combination with the histamine h1-receptor antagonist tripelennamine (1, 2.5, 5 or 10 mg/kg), on locomotor activity in mice of the cd-1 strain. when given alone, pentazocine produced slight and non-dose-related activity increments, while buprenorphine induced strong and dose-related locomotor stimulation. tripelennamine slightly increased activity by itself and ... | 2011 | 3137594 |
| [the effect of long-term exposure to gamma rays (6,7 gy) on the activity of monoamine oxidase in the hypothalamus of sheep during the anestrus period]. | 1988 | 3146833 | |
| creatinine excretion rates for evaluation of kidney function in children. | a protein load protocol for evaluation of kidney function was tested in normal children and pediatric renal patients. an overnight, timed urine collection was used for calculation of the baseline creatinine clearance and creatinine excretion rate. one hour following ingestion of a standardized protein meal (baked chicken), a 2-3 h urine collection was begun. the post-protein meal changes in creatinine clearance showed considerable variation in both the normal children and those with renal disord ... | 1988 | 3153054 |
| blood volume regulation. on the right lines at last? | 1985 | 3157061 | |
| interactions of age, gender, and sensorineural hearing loss on abr latency. | the interactive effects of gender, age, and degree of sensorineural hearing loss on the absolute latency of wave v of the auditory brain stem response were analyzed in 325 subjects with cochlear loss. norms based on these data were then applied to an analysis of the wave v latencies of 87 subjects with retrocochlear loss. results in the cochlear group revealed interactions between gender and age and between gender and degree of hearing loss. the interactive effect between gender and degree of lo ... | 2011 | 3169397 |
| specificity of pyoverdine-mediated iron uptake among fluorescent pseudomonas strains. | pyoverdine-mediated iron transport was determined for seven fluorescent pseudomonas strains belonging to different species. for all strains, cell or cell outer membrane and iron(iii)-pyoverdine combinations were compared with their homologous counterparts in uptake, binding, and cross-feeding experiments. for four strains (pseudomonas putida atcc 12633, pseudomonas fluorescens w, p. fluorescens atcc 17400, and pseudomonas tolaasii ncppb 2192), the pyoverdine-mediated iron transport appeared to b ... | 1988 | 3170485 |
| [inhalant propranolol provocation test: a new method for the differentiation between healthy and asthmatic subjects]. | 2011 | 3174581 | |
| [natural infection with anaplasma marginale in cattle of the hereford, criolla, and nelore breeds in tucumán, argentina]. | 1988 | 3175379 | |
| a sensitive elisa technique for the diagnosis of anaplasma marginale infections. | a sensitive enzyme-linked immunosorbent assay (elisa) technique using a horse radish peroxidase conjugate is described for measuring anaplasma marginale antibodies in bovine serum. this technique utilizes two antigen preparations, a 'negative' antigen derived from an animal prior to infection and a 'positive' antigen derived from a. marginale-infected red cells from the same animal following infection. this markedly reduces cross-reactions which are a result of isoantigens. absorbance values obt ... | 1988 | 3176298 |
| [enhanced antitumor action of 5-fluorouracil when used in combination with 4-methylmercaptopyrazolo[3,4-d]pyrimidine 1-nucleoside]. | mice bdf1 with l 1210 or mice balb/c with plasmacytoma mops-406 after pretreatment with ineffective doses of 1-beta-d-ribofuranosyl-4-methylmercaptopyrazolo(3,4-d)pyramidin e (25 to 100 mg/kg per 5 days) were treated with 5-fluorouracil at the optimal dose 100 mg per day. this combination produced a 1.5-2-fold or 2 to 4 fold enhancement of the antitumour effect of 5-fluorouracil without simultaneous increase of lethal toxicity. | 2011 | 3181079 |
| fibronectin phosphorylation by ecto-protein kinase. | the presence of membrane-associated, extracellular protein kinase (ecto-protein kinase) and its substrate proteins was examined with serum-free cultures of swiss 3t3 fibroblast. when cells were incubated with [gamma-32]atp for 10 min at 37 degrees c, four proteins with apparent molecular weights between 150 and 220 kda were prominently phosphorylated. these proteins were also radiolabeled by lactoperoxidase catalyzed iodination and were sensitive to mild tryptic digestion, suggesting that they l ... | 2011 | 3191954 |
| structural analyses of asparagine-linked oligosaccharides of porcine pancreatic kallikrein. | the structures of asparagine-linked oligosaccharides of porcine pancreatic beta-kallikrein are reported. asparagine-linked neutral oligosaccharides were released by n-oligosaccharide glycopeptidase digestion, and the reducing ends of the oligosaccharides were derivatized with a fluorescent reagent, 2-aminopyridine. the mixture of pyridylamino oligosaccharides was separated by reverse-phase and amide-adsorption high-performance liquid chromatography. the pyridylamino oligosaccharides were separat ... | 1988 | 3196708 |
| separation and identification of trifluralin metabolites by open-tubular liquid chromatography/negative chemical ionization mass spectrometry. | the utility of combined open-tubular liquid chromatography/negative ion chemical ionization (nci) mass spectrometry for the separation and analysis of trifluralin, a commonly used pre-emergence herbicide, and seven of its metabolites has been demonstrated. the nci mass spectra for these compounds are reported. some of the nci mass spectra were obtained from as little as 50 pg of analyte. | 2011 | 3203148 |
| cis-5-alkoxyalkyl-3-phenyl-3-(1h-imidazol-1-ylmethyl)-2- methylisoxazolidine derivatives. | 2011 | 3214079 | |
| hybridization of dna probes to a. marginale isolates from different sources and detection in dermacentor andersoni ticks. | dna from the washington, south-idaho, virginia and florida isolates of anaplasma marginale was hybridized to probes specific for anaplasma centrale and a. marginale. the a. centrale probes ac-2 and ac-4 hybridized to identical bands on all of these isolates. the hybridization patterns suggests that the virginia, florida and the south african isolates are similar. a number of bands were obtained with the washington isolate which differed from those obtained with the other isolates. probe ac-2 cou ... | 1988 | 3217095 |
| verbal communication and behaviour during meals in five institutionalized patients with alzheimer-type dementia. | five institutionalized patients with alzheimer-type dementia were observed (video-recorded) during meals. the aim was to assess their meal behaviour and social interaction. the results showed that when the patients ate without the participation of staff, the two least demented patients became 'caregivers' in the group and helped the three most demented patients to eat. when two mental nurses joined the group, the patients dropped their roles as helpers. the conversation in the group could be cha ... | 2011 | 3225360 |
| evaluation of alternatives for calculating clinical mastitis prevalence and incidence from prospective animal health monitoring schemes. | 1988 | 3232653 | |
| enzyme-linked immunosorbent assay using solubilised antigen for detection of antibodies to anaplasma marginale. | an enzyme-linked immunosorbent assay (elisa) was used to detect antibodies against anaplasma marginale. a marginale bodies were separated from parasitised erythrocytes by a modified nitrogen decompression method, sonicated, then solubilised with triton x-100 and used as the elisa antigen. in this elisa system the required amount of antigen protein was 16.2 ng for each well. in the course of experimental infections, of calves, significant antibody levels were detected by elisa and the complement ... | 1988 | 3238774 |
| metaphyseal dysostosis schmidt type. | 2010 | 3251840 | |
| [protective effect of phenobarbital in toxic liver damage by kerosine hydrocarbons in rats]. | 1988 | 3255659 | |
| modulation of type-i skin hypersensitivity reactions by bronchodilators. | 2012 | 3255688 | |
| application of methods used in survival analysis to growth and nutritional studies. | three statistical methods are described and illustrated with working examples. using these methods it is possible to include all subjects involved in cross-sectional studies in calculations of results, even if the data are incomplete at the end of the investigation. the use of censored data is taken from survival analysis. it is shown that combination of the kaplan-meier estimate, the log-rank test and the proportional hazards model gives more satisfactory results in nutritional and growth studi ... | 2012 | 3255723 |
| corticosteroid withdrawal with substitution of azathioprine in cyclosporine-treated primary cadaveric renal transplant recipients. | 2012 | 3274465 |