Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| isolation of francisella tularensis and powassan virus from ticks (acari: ixodidae) in ontario, canada. | 1984 | 6327984 | |
| landmark perspective: tularemia. | the landmark studies on tularemia by dr francis have been recognized by designating the causative organism francisella tularensis rather than bacterium tularense. a review of his original 1925 article clearly demonstrates the lasting value of critical clinical, epidemiologic, and laboratory studies. except for expansion of knowledge concerning some aspects of the epidemiology and clinical spectrum and advances in treatment and prevention, the 1925 article is as contemporary as the current litera ... | 1983 | 6358566 |
| tularemia in children. | 1983 | 6361709 | |
| [determination of tularemia antibodies by an immunoenzyme method on a solid-phase carrier (elisa)]. | elisa "sandwich" techniques have been developed and the optimum assay conditions for detecting specific antibodies in human serum samples have been determined. the possibility of using these techniques for the determination of the level of antibodies to tularemia antigens in the sera of persons immunized with live tularemia vaccine has been shown. statistically significant differences in the level of antibodies to tularemia antigen in the sera of immunized and nonimmunized persons have been esta ... | 1984 | 6377770 |
| quantum differences in oral susceptibility of voles, microtus pennsylvanicus, to virulent francisella tularensis type b, in drinking water: implications to epidemiology. | shedding nephritis in voles with chronic tularemia is the probable source of frequent contamination of streams over wide areas of the northern hemisphere. however, voles inoculated parenterally with as few as one dex viable cells of francisella tularensis palaearctica succumb uniformly to acute tularemia, whereas voles, beavers, and muskrats often thrive in waters contaminated with the organism. nevertheless, water-borne epizootics do occur in these animals, and at these times streams are heavil ... | 1983 | 6381031 |
| an endemic case of tularemia in the mountain hare (lepus timidus) on the island of stora karlsö. | in september 1983, an epizootic of unknown cause broke out among the mountain hares on the island of stora karlsö, which is located outside the coast of gotland. one hare was sent in the national veterinary institute for post-mortem examination. the hare showed lesions in liver, spleen, and bone-marrow typical for tularemia. the specimens were positive for francisella tularensis with fluorescent-antibody test. tularemia has not been observed earlier in this part of sweden. it is supposed that th ... | 1984 | 6393050 |
| persistence of francisella tularensis mccoy et chapin tularemia agent in the organism of highly sensitive rodents after oral infection. | in the literature there are no data on the possibility of obtaining in experiment non-fatal tularemia infection (persistence) in rodents highly sensitive to it (group i) when using highly virulent strains circulating in nature for infection by natural routes. our detailed experiments on 1483 adult voles microtus rossiaemeridionalis ogn. (syn. m. subarvalis meyer et al.) of laboratory origin using virulent strains of francisella tularensis holarctica ols. et meshch. and natural alimentary infecti ... | 1984 | 6396330 |
| [new developments in the study of natural tularemia foci in the ussr]. | 1984 | 6397015 | |
| comparison of the effects of acid and base hydrolyses on hydroxy and cyclopropane fatty acids in bacteria. | the cellular fatty acid compositions of legionella oakridgensis, brucella suis, pseudomonas aeruginosa, and francisella tularensis were compared after base hydrolysis (saponification), acid hydrolysis, and acid methanolysis procedures were used to release the fatty acids. the branched-chain, unsaturated, saturated, and ester-linked hydroxy acids were released as effectively with saponification at 100 degrees c for 30 min as with acid hydrolysis or acid methanolysis at 85 degrees c for 16 h. alth ... | 1983 | 6418758 |
| serologic studies on brucellosis, leptospirosis and tularemia in moose (alces alces) in quebec. | blood samples were obtained from 208 moose in la vérendrye and matane reserves and in laurentides park, quebec, canada. sera were tested for antibodies to brucella abortus, leptospira interrogans serovar ballum, canicola, grippotyphosa, hardjo, icterohaemorrhagiae and pomona, and francisella tularensis. fifteen sera contained evidence of prior exposure to f. tularensis. only one animal was a seroreactor to l. interrogans serovar grippotyphosa and none of them had antibodies to b. abortus. | 1984 | 6429355 |
| outbreak of tick-borne tularemia--south dakota. | 1984 | 6434937 | |
| a monoclonal antibody specific for the a antigen of brucella spp. | two murine monoclonal antibodies of the igg3 class have been isolated after immunization with brucella abortus. an indirect immunofluorescence test was used to screen hybridoma supernatants and subsequently to determine the cross-reactivity of the monoclonal antibodies with other bacteria. one monoclonal antibody reacted with all the smooth brucella biotypes tried and with yersinia enterocolitica serogroup 0:9, though not with rough br. ovis or with strains of escherichia, proteus, salmonella, p ... | 1984 | 6438272 |
| [examination of a natural tularemia focus in the crimea using a passive hemagglutination reaction system]. | 1980 | 6445649 | |
| [biological properties of the strains f. tularensis isolated in slovakia (author's transl)]. | 1980 | 6448103 | |
| [isolation of the causative agent of tularemia from an inoculum from skin lesions in the ulcerobubonic form of the disease]. | a case of tularemia in a human patient infected through the sting of a gadfly (tabanus) is described. the causative agent of the disease was isolated from the patient with the ulcerobubonic form of the disease by the method of the direct inoculation of the contents of the patient's cutaneous effect. the properties of the isolated culture were established; the strain thus obtained was classified as a representative of the geographical race francisella tularensis holarctica 01s. the causative agen ... | 1980 | 6449122 |
| [effective method of detecting winter epizootics of tularemia]. | 1981 | 6454317 | |
| [experience with a bacteriologic and serologic study of a tularemia epizootic in rodents in a natural focus of the meadow and field type]. | the autumn-winter (1977-1978) tularemia epizootic in small murine rodents was revealed and studied at the natural focus of the meadow and field type in the south of the moscow region. the efficacy of the serologic method (the antibody neutralization test) of studying the organs of the caught rodents and the bodies of dead rodents was found to be greater than that of the traditional bacteriologic methods (26.6% and 9.6%, respectively). the serologic study of 908 specimens of avian excrements coll ... | 1981 | 6454319 |
| [nutrient requirements of francisella tularensis]. | 1984 | 6464571 | |
| tularemia with unusual laboratory characteristics in south dakota children. | 1984 | 6589779 | |
| [mechanism of natural penicillin resistance in the causative agent of tularemia]. | beta-lactamase and penicillinacylase were detected in the tularemia causative agent. these enzymes participated in the mechanism of natural resistance of the microorganisms to penicillins. it was shown that the growth temperature had a significant effect on the beta-lactamase activity. the penicillin resistance marker was not eliminated with the use of acridine orange, ethidium bromide or sodium dodecylsulfate. | 1983 | 6605111 |
| [isolation and purification of penicillinase from francisella tularensis]. | beta-lactamase was isolated from the cells of a penicillinase-producing strain of the tularemia causative agent. it was purified 100 times. by its properties (the substrate profile, km, temperature optimum and thermostability) beta-lactamase differed from penicillinases isolated from other sources. | 1983 | 6606391 |
| tularemia pneumonia mimicking legionnaires' disease: isolation of organism on cye agar and successful treatment with erythromycin. | a 46-year-old man showed a clinical response when treated with parenteral erythromycin for what was initially thought to be legionnaires' disease, but an organism isolated from his pleural fluid on cye agar was subsequently identified as francisella tularensis. tularemia should be suspected in all cases of atypical pneumonia in the appropriate setting. erythromycin may be effective empiric therapy in such cases. because of the possibility of inadvertent isolation of francisella tularensis on cye ... | 1983 | 6612398 |
| [the effect of aerosolization on the changes in major biological properties of the vaccine strain of francisella tularensis]. | the exposure of f. tularensis vaccine strain 15/10 in the form of aerosol for more than 10 minutes results in the decrease of its virulence, immunogenicity and the content of species-specific antigen and in the increase of the dissociation level. proceeding from this fact, during aerosol immunization with this vaccine strain exposure must not exceed 5 minutes for unstabilized aerosol and 10 minutes for aerosol stabilized with 5% glycerin. under these conditions the properties of f. tularensis st ... | 1983 | 6613417 |
| enzyme-linked immunosorbent assay (elisa) with bacterial sonicate antigen for igm, iga, and igg antibodies to francisella tularensis: comparison with bacterial agglutination test and elisa with lipopolysaccharide antigen. | an enzyme-linked immunosorbent assay (elisa) with bacterial sonicate (s) as antigen developed for determining the presence of igm, iga, and igg antibodies to francisella tularensis was compared with the bacterial agglutination (ba) test and a corresponding elisa using lipopolysaccharide (lps) antigen. of the organisms tested, f tularensis was the only one to cause significant inhibition, indicating the specificity of the s-elisa. ba test titers correlated significantly with antibody levels in al ... | 1983 | 6631062 |
| tularemia in a rough-legged buzzard (buteo lagopus) and a ural owl (strix uralensis). | 1983 | 6644938 | |
| hepatic abscess complicating ulceroglandular tularemia. | in a patient with the clinical features of classic ulceroglandular tularemia a solitary hepatic abscess was found during an ultrasound examination. hepatic tularemia has rarely been reported since the advent of specific therapy, which prevents the disease from reaching the disseminated state. this case, however, shows that the liver can be involved early in the course of tularemia. increased serum levels of hepatic enzymes may be the only sign of such a complication. | 1983 | 6652596 |
| [higher fatty acid composition of the intraspecific taxa of francisella tularensis]. | the higher fatty acid composition of 27 f. tularensis strains differing in their biological properties and belonging to different intraspecific taxons has been determined with the use of gas and liquid chromatography. all the strains under study have been found to possess similar fatty acid spectra, characterized by the presence of long straight-chain fatty acids (saturated and unsaturated) with the number of carbon atoms varying from 10 to 26. quantitative differences content of individual fatt ... | 1983 | 6659760 |
| [comparative study of the basic immunological reactions for assessing tularemia immunity in inoculated persons or those who have had the disease]. | in the comparative study of immunological tests used for the determination of immunity to tularemia in vaccinees the greatest number of persons with the positive reaction was detected by means of the tularine skin test. former tularemia patients retained allergic skin reaction to this test irrespective of the time of the disease. | 1983 | 6659772 |
| tularaemia transmitted by ticks (dermacentor andersoni) in saskatchewan. | common wood ticks (dermacentor andersoni) collected from saskatchewan landing provincial park, saskatchewan in the spring of 1982 transmitted a lethal tularaemia infection to four of six rabbits. francisella tularensis organisms were isolated from tissues taken from the dead rabbits and identified from subcultures using an indirect immunofluorescent antibody assay. one human associated with the animals developed symptoms of tularaemia and, after successful therapy, had a significant increase in ... | 1983 | 6667429 |
| [results of the study of bird droppings collected in the lithuanian ssr for the purpose of searching out tularemia epizootics]. | there are practically no records of cases of tularemia among humans in the lithuanian ssr. nevertheless, the mass sero-allergic survey of the population for tularemia, carried out 10-12 years ago, showed that 2.3% of the adult population in the republic had had contacts with the causative agent of this infection. the work was aimed at the determination of the present activity of the foci of tularemia. during 6 years in 22 rural districts 2582 samples of avian excrements, containing bones and woo ... | 1984 | 6711197 |
| [antibody dynamics of carnivorous mammals and corvine birds infected with francisella tularensis]. | the time course of antibody formation in carnivorous mammals and corvine birds infected with a single injection of f. tularensis has been experimentally studied in the agglutination test and the passive hemagglutination test. in carnivorous mammals the allergic transformation of the body has been established by means of the leukocytolysis test. | 1984 | 6741361 |
| [use of an immunoenzyme method on a solid-phase carrier for determining the tularemia antigen]. | the method of the highly sensitive (up to 10 ng/ml) and specific determination of soluble tularemia antigen, based on the use of "sandwich" type elisa techniques, has been developed. the dependence of the specificity and sensitivity of the method on the degree of purification of antibodies and their peroxidase conjugates used in the assay has been studied. the study has revealed that the best results can be obtained with the use of purified igg and its conjugate free of unbound peroxidase. both ... | 1984 | 6741370 |
| [time course of the production of immunoglobulins in patients with tularemia]. | 1984 | 6748218 | |
| [disinfection of fresh-frozen sections of ticks infected with the causative agent of tularemia in histoenzymatic studies]. | 1982 | 6750344 | |
| bacterial immunizations. | 1980 | 6766272 | |
| glucose and alanine metabolism during bacterial infections in rats and rhesus monkeys. | to investigate the effects of bacterial infection on glucose and alanine metabolism, a variety of studies were carried out in rat and monkey models. these included glucose turnover by a pulse-dose technique in infected rats; alanine and glucose production and utilization in control and septic monkeys; in vivo measurement of gluconeogenesis in rats, with and without an alanine load; the in vitro rate of glucose formation from various substrates by isolated liver perfusion and hepatic cells; and i ... | 1980 | 6768954 |
| [current status of vaccine treatment of zoonotic infections]. | 1980 | 6776687 | |
| [characteristics of microbial multiplication in parenterally infected xenopsylla cheopis (siphonaptera) fleas]. | being inoculated parenterally various microbes cause the fleas x. cheopis a stable infection which, as a rule, is preserved in experimental insects to the end of life. reproducing intensively listeria monocytogenes and salmonella typhimurium caused the death of all ectoparasites in 3 to 5 days. the increase in abundance of escherichia coli, yersinia pseudotuberculosis, y. enterocolitica and vaccine strains of y. pestis "ev" and francisella tularensis went on gradually and infected fleas lived up ... | 1980 | 6780964 |
| induction of resistance to tuberculosis in mice with defined components of mycobacteria and with some unrelated materials. | factors contributing to protection against experimental tuberculosis have been studied with refined and well-characterized fractions from mycobacteria and with certain unrelated antigens. mice were vaccinated intravenously with various combinations of materials presented on minute oil droplets in saline emulsion and were later challenged by aerosol. the minimal composition of an effective vaccine was p3 (a trehalose mycolate similar to cord factor) plus an antigen, which could be tuberculo-prote ... | 1982 | 6805154 |
| [cytochemical changes in the peripheral blood leukocytes of guinea pigs inoculated against plague, tularemia and anthrax]. | the immunization of guinea pigs with trivaccine and monovaccines against plaque, tularemia and anthrax induces a decrease in the activity of acidic phosphatase in lymphocytes, as well as a decrease in the number of lymphocytes containing this enzyme. a decrease in the activity of alkaline phosphatase and peroxidase had been found to occur in neutrophil leukocytes. besides, neutrophil leukocytes have shown an increase in the activity of acidic phosphatase and nonspecific esterases. the study base ... | 1982 | 6812331 |
| tularemia complicated by acute renal failure. | acute renal failure has been a rare, uniformly fatal complication of infection with francisella tularensis. the literature suggests that either acute tubular necrosis, interstitial nephritis, or glomerulonephritis may be responsible for this syndrome. we have described a patient with tularemia who had nonoliguric acute renal failure probably due to interstitial nephritis and who recovered slowly but spontaneously during antimicrobial therapy with doxycycline. | 1983 | 6823614 |
| phagocytosis and killing of francisella tularensis by human polymorphonuclear leukocytes. | bacteria of a wild strain of francisella tularensis were less efficiently killed by human polymorphonuclear leukocytes than were bacteria of an attenuated strain. this finding was explained to some extent by a less efficient phagocytosis, but bacteria of the wild strain also seemed to be more resistant to killing after ingestion. | 1983 | 6832815 |
| a serological survey of antibodies against francisella tularensis in some swedish mammals. | tularemia occurs in sweden as an epizootic among the mountain hare. little is known about the occurrence of the disease in other animals in this country. for this reason serum samples from 28 cattle, 83 moose, 110 beavers and 97 mountain hares were investigated for the presence of antibodies against francisella tularensis. the antibody levels against f. tularensis found in moose and cattle were generally low and also in a low incidence. this indicates that these species are not susceptible to tu ... | 1983 | 6878028 |
| granulomatous pleuritis caused by francisella tularensis: possible confusion with tuberculous pleuritis. | granulomatous pleuritis, diagnosed by pleural biopsy, is rarely caused by disease processes other than tuberculosis. we present a case of granulomatous pleuritis caused by francisella tularensis that occurred in a 55-yr-old male sheep shearer with an exudative, lymphocytic, pleural effusion. confirmation of the diagnosis was made by elevated serum agglutination titers against f. tularensis and detection of the organism in a pleural biopsy specimen by the glucose oxidase immunoenzyme technique. w ... | 1983 | 6881689 |
| clinically mild tularemia associated with tick-borne francisella tularensis. | between may 9 and july 3, 1979, 12 cases of glandular or ulceroglandular tularemia occurred in residents of the crow indian reservation in southcentral montana; only 13 cases had been reported from this geographic area in the preceding 25 years. the illness was mild, characterized by fever and cervical or occipital adenopathy. systemic symptoms were self-limited although residual lymphadenopathy was common. francisella tularensis was isolated from ticks (dermacentor variabilis), the suspected ve ... | 1983 | 6886487 |
| [development of a serological micromethod for the detection of antibodies against francisella tularensis]. | 1980 | 6982628 | |
| a probable endocrine basis for the depression of ketone bodies during infectious or inflammatory state in rats. | the effects of infection with streptococcus pneumoniae, francisella tularensis, and venezuelan equine encephalitis virus as well as inflammatory stress induced by the administration of turpentine and endotoxin on plasma ketone bodies and insulin were studied in white rats. all of the infectious/inflammatory stresses caused a significant decrease in the ketonemia of fasting and an elevation of plasma insulin. when a pneumococcal infection was initiated in a diabetic rat, inhibition of fasting ket ... | 1980 | 6993191 |
| [technic of studying microorganism viability in a simulated aerosol state on fiberglass microfilaments]. | a specially developed method of studying the viability of microorganisms in the simulated aerosol state on glass microfibers was used to show that the survival rate of e. coli and f. tularensis on fiber-glass spheres was similar to that in true aerosol, as observed in a static aerosol chamber. the proposed method allows to study the viability of microbial cells after prolonged existence in aerosol under any environmental condition both in open spaces and closed rooms. | 1980 | 7001815 |
| cell-mediated immunity against francisella tularensis after natural infection. | 31 subjects with tularemia recently or up to 11 years earlier were studied for cell-mediated immunity against francisella tularensis using formalin-killed bacteria as antigen in the lymphocyte blast transformation test. lymphocytes from all the subjects responded to f. tularensis antigen both in separated mononuclear cell and whole blood cultures, whereas lymphocytes from 12 controls responded not at all or only weakly to hig antigen concentrations and only in separated mononuclear cell cultures ... | 1980 | 7006062 |
| influence of complement on the chemiluminescent response of human leukocytes to immune complex. | vaccine bacteria of francisella tularensis were mixed with human serum containing specific antibodies against the same organism, and the mixture was incubated at 37 degrees c for 30 min. the mixture induced a two-peak chemiluminescent response in polymorphonuclear leukocytes. the initial peak was induced by a soluble agent, formed during incubation. the formation of this agent involved the activation of complement component c5. the second peak of the chemiluminescent response was induced by the ... | 1980 | 7011971 |
| mothers of infants with neonatal group b streptococcal septicemia are poor responders to bacterial carbohydrate antigens. | serum antibodies against various carbohydrate antigens were studied in 16 mothers of infants with serious infections caused by group b streptococci (gbs) (the study group), and compared with a control group of 29 urogenital carriers of gbs who gave birth to neonatally healthy infants. using a radioimmunoassay for the determination of antibodies to gbs types ia, ib, ii and iii, it was found that the study group had significantly lower levels of igg antibodies to each of the 4 gbs types than the c ... | 1982 | 7035374 |
| towards serodiagnosis of serratia marcescens infections: examination of sera from noninfected patients and from experimentally infected rabbits for anti-h and anti-o antibodies; s. marcescens o-antigen cross-reactions with those of other enterobacteriaceae. | sera from 100 patients not infected with serratia marcescens at the time of hospital admission lacked detectable h-immobilizing antibodies against all 20 currently recognized h-antigens of this microorganism. however, various patient sera revealed elevated titers of o-agglutinins against several of the 20 o-antigens of s. marcescens, in a particular o-antigens, o1, o3, o4, o5, o7, o8, o10, o11, o16, o17, o18, o19, and o20. rabbit anti-shigella serogroup b immune serum cross-reacted with s. marce ... | 1981 | 7036590 |
| [experimental latent tularemia in common voles]. | common voles (microtus subarvalis) were infected with tularemia by feeding them with the corpses of the animals which had been infected with francisella tularensis strain having somewhat decreased virulence. this resulted in nonlethal infection in 14 out of 433 voles used in the experiment. a considerable part of the animals having had the infection developed bacterial carriership (11 out of 13 animals) with bacteriuria (8 out of 11 animals) lasting up to 2 months. the persistence of francisella ... | 1982 | 7043979 |
| the use of fa-technique for detecting francisella tularensis in formalin fixed material. a method useful in routine post mortem work. | 1981 | 7046398 | |
| tularemia in canada with a focus on saskatchewan. | although rare among humans in canada, tularemia is often endemic in wildlife. the inhabitants of rural areas are especially likely to be exposed to the causative bacterium, francisella tularensis, through trapping or through the bites of arthropods. muskrats have replaced rabbits as the principal source of infection, as illustrated by a familial outbreak of oropharyngeal tularemia in saskatchewan. in humans the disease has six distinct forms and can be asymptomatic, but it generally comes to med ... | 1982 | 7046896 |
| "muskrat fever": two outbreaks of tularemia near montreal. | 1982 | 7046897 | |
| the effects of strenuous exercise on infection with francisella tularensis in rats. | to investigate the effects of strenuous forced exercise on the course and complications of a bacterial infection and on myocardial responses and performance capacity, rats with tularemia (characterized by pyogranulomatous hepatic and splenic lesions) were exercised by swimming on days 0-6 of infection. levels of glutamic oxaloacetic and pyruvic transaminases in plasma, densities of pyogranulomatous lesions, and bacterial counts in blood, liver, and spleen were similar in exercising and resting r ... | 1982 | 7077093 |
| antibodies to francisella tularensis in the snowshoe hare (lepus americanus struthopus) populations of nova scotia and prince edward island and in the moose (alces alces americana clinton) population of nova scotia. | 1982 | 7093820 | |
| cell-mediated and humoral immunity induced by a live francisella tularensis vaccine. | live attenuated francisella tularensis vaccine induced long-lasting humoral and cell-mediated immune responses in all 13 subjects studied. lymphocyte blast transformation reactivity to f. tularensis appeared 2 weeks after vaccination in most subjects and remained unchanged for up to 1.5 years. similarly, in most recipients, antibodies against f. tularensis were detectable by both the enzyme-linked immunosorbent assay (elisa) and the agglutination method from 2 weeks after vaccination, although d ... | 1982 | 7095859 |
| [detection of alpha-naphthyl acetate esterase in francisella tularensis]. | the activity of alpha-naphthyl-acetate esterase (alpha-nae) has been studied in francisella tularensis strains belonging to 3 subspecies. alpha-nae has been detected spectrophotometrically in native cells and cell extracts of the virulent nonarctic strains schu and cole, holarctic virulent strain no. 503/841 and holarctic vaccine strain no. 15/10, central asian virulent strain no. 543, as well as their attenuated variants. in all the strains studied the presence of 7 alpha-nae isoenzymes has bee ... | 1982 | 7113529 |
| [study of a natural focus of tularemia in the small carpathian mountains]. | 1982 | 7139368 | |
| infraspecific taxonomy of tularemia agent francisella tularensis mccoy et chapin. | the authors investigated 286 strains of the tularemia microbe isolated in a number of countries of the old and the new world from humans, hares, rodents, ticks, water and other objects, including 217 strains from the ussr and 69 strains from other countries. as a result, the earlier observed subspecific differences in the biological properties of the tularemia strains isolated in different regions were reconfirmed on an extensive material. it is proposed to designate the three subspecies disting ... | 1982 | 7142690 |
| immunity against francisella tularensis in northern finland. | immunity against francisella tularensis in northern finland was studied by antibody determination and by the lymphocyte blast transformation test previously shown to reliably demonstrate immunity to tularemia. seven out of 1072 (0.7%) red cross volunteer blood donors from the rural areas around oulu had agglutinating antibodies with a titre of 80 or higher, and 5 (0.5%) also had cell-mediated reactivity against f. tularensis. none of them was aware of ever having had tularemia, and only 1 recoll ... | 1982 | 7146829 |
| [resistance to the venezuelan equine encephalomyelitis virus in immunization with live tularemia vaccine]. | guinea pigs immunized with live tularemia vaccine have been found to possess pronounced resistance to venezuelan equine encephalomyelitis virus infection. antiviral resistance induced by the vaccine has been found to persist for 1 month. one of the possible mechanisms, though not the only one, of this resistance is the stimulation of macrophages by tularemia vaccine, which results in the enhancement of their resistance to the cytotoxic action of the virus. | 1982 | 7148228 |
| reduction of brucella species and francisella tularensis cross-reacting agglutinins by dithiothreitol. | cross-reaction agglutinin titers to brucella abortus antigen were found in 42 of 128 tularemia serum specimens, and cross-reaction titers to francisella tularensis antigen were found in 8 of 34 brucellosis serum specimens. the cross-reaction titers were reduced to 10 or less by dithiothreitol, suggesting that the titers are due to immunoglobulin m antibody. | 1982 | 7153327 |
| sensitivity to macrolide antibiotics and lincomycin in francisella tularensis holarctica. | among the 345 f. tularensis holarctica strains isolated in europe, asia and north america, two variants were found: one sensitive and the other resistant to erythromycin, oleandomycin and lincomycin. these characteristics were not associated with virulence, antigenicity, biochemical activity or source of isolation and displayed high stability in passages in laboratory animals or multiple passages in culture media. the two variants are proposed to be designated as biotype (biovar) i, erythromycin ... | 1980 | 7190590 |
| detection of enzootic territories and exploration of tularemia epizootics in different types of natural foci of this infection by serological examination of bird pellets and the excrements of beasts of prey. | serological analysis (reaction of antibody neutralization) of pellets of birds and excrements of beasts of prey for the presence of tularemia microbe antigen is an efficient method of detection and investigation of epizootics in all types of natural foci of the infection and also for the exploration of new focal territories. the method permits with small expenditure of labour and within a short time, to collect material characterizing the epizootic process on a large territory. tularemia epizoot ... | 1980 | 7190592 |
| demonstration of opsonizing antibodies to francisella tularensis by leukocyte chemiluminescence. | twenty-three individuals were vaccinated with a viable attenuated strain of francisella tularensis, and blood was collected at various time intervals during 4 weeks. to demonstrate opsonizing antibodies, a mixture of serum and vaccine bacteria was incubated, whereafter the chemiluminescence response of polymorphonuclear (pmn) leukocytes to this mixture was recorded. no opsonizing antibodies against f. tularensis were found in sera obtained before vaccination. eleven days after vaccination, sera ... | 1980 | 7216416 |
| differential alterations in host peripheral polymorphonuclear leukocyte chemiluminescence during the course of bacterial and viral infections. | previous studies have shown that stimulation of the oxidative metabolism in polymorphonuclear leukocytes (pmn) by in vitro phagocytosis of various microorganisms results in photon emission, termed chemiluminescence (cl). studies were conducted to determine whether bacterial and viral infections induce enhanced basal endogenous host peripheral pmn cl in the absence of in vitro phagocytic stimulation. nonimmune rats and guinea pigs as well as immune rats were inoculated with various doses (10(5) t ... | 1980 | 7228389 |
| [peroxidase activity of tularemia bacteria]. | 1981 | 7234236 | |
| [leukocytolysis reaction and the neutrophil damage test as methods of demonstrating allergy to francisella tularensis]. | 1981 | 7269912 | |
| tularemia simulating acute myocardial infarction. | 1981 | 7299963 | |
| case report. tularemia in ohio: report of two cases and clinical review. | although unusual, human tularemia continues to be reported from areas of the united states which are not heavily endemic for the disease. two patients with ulceroglandular tularemia diagnosed in ohio are described. the causative microorganism, francisella tularensis, is a small, pleomorphic gram negative coccobacillus which requires special microbiological media for laboratory isolation. in nature, the organism is usually transmitted to man by the handling of infected animal tissues and body flu ... | 1981 | 7315867 |
| [further study of intraspecific taxonomy of francisella tularensis]. | 1981 | 7331604 | |
| [natural focus of tularemia on the kerchen peninsula (crimea)]. | the study confirming the existence of the steppe-type natural focus of tularemia on the kerch peninsula has been carried out. for the first time the cultures of francisella tularensis have been isolated. voles and house mice play the main role in the circulation of the infection. the parasitic system comprises ticks (ixodidae and nyalomma), as well as some species of fleas. in carrying out erizootological studies for detecting tularemia in the crimea the use of low temperature (0 degrees c) for ... | 1981 | 7331615 |
| modulation of the immune response by aerodin. ii. influence on the antiinfectious resistance in rabbits and guinea pigs experimentally infected by francisella tularensis and pseudomonas aeruginosa. | 1981 | 7332454 | |
| respiratory tularemia: comparison of selected routes of vaccination in fischer 344 rats. | fischer 344 rats were given the attenuated live vaccine strain of francisella tularensis by small-particle aerosol, intranasal instillation, or intraperitoneal, intramuscular, or subcutaneous injection. all of the vaccinated rats developed subclinical infection by 3 days after exposure, which cleared by day 28. temporal patterns and concentrations of the live vaccine strain organism within the hosts were dependent on the route of vaccination. pathological alterations were limited to minimal lung ... | 1981 | 7333669 |
| [morphological studies for invasion and intracellular growth of f. tularensis in cultured cells (author's transl)]. | 1981 | 7345173 | |
| treatment of tularemia, including pulmonary tularemia, with gentamicin. | an alternative to streptomycin for treatment of possible tularemia would be useful on occasions when a patient develops a perplexing pneumonia that does not respond to initial treatment. in geographic areas where tularemia is endemic, an antimicrobial drug that is bactericidal for francisella tularensis and is also effective against a spectrum of common pulmonary pathogens, including the enterobacteriaceae and most strains of pseudomonas aeruginosa, would be desirable. the purposes of this repor ... | 1980 | 7352712 |
| cross-reaction to legionella pneumophila antigen in sera with elevated titers to pseudomonas pseudomallei. | a significantly greater incidence (p less than 0.005) of legionella pneumophila microagglutination titers greater than or equal to 32 was found in sera with elevated titers to pseudomonas pseudomallei as compared with sera with negative titers for p. pseudomallei antibodies. the greater incidence of l. pneumophila titers in these sera suggests that l. pneumophila and p. pseudomallei share an antigen. the incidence of l. pneumophila microagglutination titers of greater than or equal to 32 in sera ... | 1980 | 7354127 |
| [characteristics of the tularemia prevention measures in the natural foci of the carpathian region]. | 1980 | 7376572 | |
| host resistance to tick-borne pathogens by virtue of resistance to tick infestation. | 1980 | 7377869 | |
| [cross immunity to plague and tularemia]. | 1980 | 7395403 | |
| [method of detecting bacteriocins in the agent of tularemia]. | 1980 | 7415670 | |
| mechanisms of protective immunogenicity of microbial vaccines: effects of cyclophosphamide pretreatment in venezuelan encephalitis, q fever and tularaemia. | administration of high-dose (250 mg/kg) cyclophosphamide (cy) to guinea-pigs and mice 3 days prior to immunization with inactivated vaccine derived from venezuelan encephalitis virus (ve), coxiella burnetii and francisella tularensis resulted in accentuated and prolonged delayed-type hypersensitivity (dth) and in vitro cellular immunity (cmi) to specific antigen. humoral antibody were either absent or significantly lower in cy-pretreated animals compared to immunized non-pretreated controls. cy ... | 1980 | 7438552 |
| glucan-induced enhancement of host resistance to selected infectious diseases. | we conducted studies with mice, rats, and monkeys which demonstrated the ability of glucan to induce either nonspecific or specific enhancement of host resistance to infectious diseases. intravenous pretreatment of mice with glucan significantly enhanced the survival of mice challenged with either venezuelan equine encephalomyelitis (vee) virus or rift valley fever virus. pretreatment was beneficial when initiated 3 days before challenge with vee virus and 7 days before challenge with rift valle ... | 1980 | 7439978 |
| comparative analysis of antibodies to francisella tularensis antigens during the acute phase of tularemia and eight years later. | approximately 8 years after treatment for tularemia, 14 of 22 (63.6%) individuals tested still had a positive microagglutination test for francisella tularensis antibodies. an enzyme-linked immunosorbent assay for anti-f. tularensis outer membrane antibodies was positive for 55% (immunoglobulin a [iga]), 95% (igg), and 27% (igm) of the late-phase sera, but with antibody levels significantly reduced from those in the acute-phase sera. igg and iga antibody levels in the late-phase sera showed sign ... | 1994 | 7496953 |
| identification and classification of different isolates of francisella tularensis. | the causative agent of tularemia, francisella tularensis, occurs in two main biovars, the highly virulent f. t. biovar tularensis, found in north america; and the less virulent biovar palaearctica, found all over the northern hemisphere. two other biovars have been proposed, f. t. biovar mediaasiatica and f. t. biovar palaearctica var. japonica. in sweden tularemia is most frequently observed in man and varying hares (lepus timidus), and occasionally in other species. tularemia in hares is norma ... | 1993 | 7510445 |
| [a highly sensitive, homogeneous method for determining antibodies and antigens by using liposomes, monoclonal antibodies and complement]. | a simple and sensitive method for the determination of francisella tularensis antigen and antibodies to this antigen by means of the complement lysis of liposomes sensitized with f. tularensis lipopolysaccharide (lps) is proposed. the possibility of participation of monoclonal antibodies (mcab) in the complement-dependent lysis of liposomes has been studied. the method permits the detection of 50-100 ng/ml of soluble lps antigen in the presence of antiserum or mcab igg f-b11-x and of 50-10 ng/ml ... | 1993 | 7520654 |
| [the determination of the antigenic determinant of protective monoclonal antibodies specific to the francisella tularensis lipopolysaccharide]. | f. tularensis lipopolysaccharide (lps) was studied with the use of monoclonal antibodies (mcab) having protective properties. the binding site of these mcab (igg2a) is localized on the o-chain of lps. in contrast to lps isolated from vaccine strain 15, lps isolated from f. tularensis cells in the r-form has no o-chains and does not interact with mcab. | 1993 | 7520655 |
| nitric oxide: cytokine-regulation of nitric oxide in host resistance to intracellular pathogens. | to discover how nitric oxide (no) synthesis is controlled in different tissues as cells within these tissues combat intracellular pathogens, we examined three distinctively different experimental murine models designed for studying parasite-host interactions: macrophage killing of leishmania major; nonspecific protection against tularemia (francisella tularensis) by mycobacterium bovis (bcg); and specific vaccine-induced protection against hepatic malaria with plasmodium berghei. each model para ... | 1994 | 7537721 |
| electroporation of francisella tularensis. | 1995 | 7550729 | |
| [methodical bases of the use of erythrocytic diagnostic agents as phagocytosis objects]. | the error in assessment of the neutrophil phagocytic activity is 5.8%. this is attained by removal of conglomerations of phagocytosis objects and by ruling out the minimal variations in the duration of contact between the blood and foreign corpuscles and preparation of smears to be examined on the same slide. the content of up to 90% red cells does not influence the neutrophil phagocytic activity, and higher concentration reduces its level. | 1995 | 7582767 |
| levels of interleukin 6 and tumor necrosis factor in serum from humans vaccinated with live, attenuated francisella tularensis. | the levels of interleukin 6 (il-6) and tumor necrosis factor alpha in serum did not change significantly during the course of immunization with the live vaccine strain of francisella tularensis. higher levels of circulating il-6 were found in the sera of vaccinees with good antibody responses than in the sera from nonresponders. preimmunization levels of il-6 in serum were also higher in responders than in nonresponders. | 1995 | 7583930 |
| seroepidemiologic study of three zoonoses (leptospirosis, q fever, and tularemia) among trappers in québec, canada. | this study was undertaken to evaluate the prevalence of antibodies against francisella tularensis, coxiella burnetii, and certain serovars of leptospira interrogans among trappers in québec, canada. muskrat trapping was identified as a risk factor for f. tularensis infection, whereas having a cat at home apparently protected trappers against infection by l. interrogans. high percentages of control sera were positive for antibodies against c. burnetii (15%) and l. interrogans (5%), most frequentl ... | 1995 | 7583933 |
| analysis of the dnak molecular chaperone system of francisella tularensis. | we have cloned the francisella tularensis (ft) grpe-dnak-dnaj heat-shock genes which are organized in that order. these genes allow heterologous genetic complementation of each respective mutant strain of escherichia coli (ec) for bacteriophage lambda growth. the nucleotide sequences of the ft grpe-dnak-dnaj genes and the deduced amino-acid sequences share significant homologies with their respective ec counterparts. the ft dnak and dnaj proteins cross-react with polyclonal antibodies raised aga ... | 1995 | 7590305 |
| adjuvanticity of iscoms incorporating a t cell-reactive lipoprotein of the facultative intracellular pathogen francisella tularensis. | immunostimulating complexes (iscoms) are known to be highly effective adjuvants for envelope antigens of viral agents, but have not been evaluated for use with antigens of intracellular bacteria. balb/c mice were subcutaneously immunized with iscoms into which the t cell-reactive membrane protein tul4 of francisella tularensis had been incorporated. spleen cells from the immunized mice responded in vitro to tul4 and to heat-killed f. tularensis live vaccine strain (lvs) with proliferation and pr ... | 1995 | 7631511 |
| [the effect of recombinant tumor necrosis factor on antibody formation in mice immunized with a preparation of the outer membranes from francisella tularensis]. | the influence of exogenic human recombinant tumor necrosis factor (tnf-alpha) on antibody production in mice immunized with the preparation of f.tularensis outer membranes (om) was studied. tnf-alpha was injected into mice in doses of 0.001-10 i.u. before and simultaneously with the injection of the preparation of f.tularensis om. the levels of tularemia antibodies, determined by elisa techniques, and the number of antibody-producing cells (apc) were studied. the study revealed that recombinant ... | 1995 | 7653140 |
| [the activity of the phagocytic bactericidal systems in intact guinea pigs and in guinea pigs immunized against tularemia]. | the activities of nadp-oxidase and glucose-6-phosphate dehydrogenase in mononuclear phagocytes and polymorphonuclear leukocytes (pml) during the phagocytosis of francisella tularensis and the influence of immunization of on the activity of oxygen-dependent metabolism were studied. the phagocytosis of f.tularensis was found to be accompanied by a rise in the activity of nadp.h-oxidase and glucose-6-phosphate dehydrogenase. in the process of immunogenesis the rearrangement of the enzymatic system ... | 1995 | 7653143 |
| mixed natural focus of tick-borne encephalitis, tularemia and haemorrhagic fever with renal syndrome in west slovakia. | total of 923 small mammals of 7 species were collected in locality záhorská ves, west slovakia, in 1990-1992. among examined small mammal species it was clethrionomys glareolus (48.7% of total, 17.5% positive for tick-borne encephalitis (tbe) virus antibodies), apodemus flavicollis (29.7% of total, 17.5% positive), a. sylvaticus (11.3% of total, 16.3% positive), and microtus arvalis (6.2% of total, 10.5% positive). the most abundant tick species (larval and nymphal stages) on small mammals was i ... | 1995 | 7676942 |