Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| high-risk hpv dna status and p16 (ink4a) expression as prognostic markers in patients with squamous cell cancer of oral cavity and oropharynx. | to determine and compare the influence of the hpv dna status and p16(ink4a) expression on the outcome of postoperative radiotherapy for squamous cell cancer of the oral cavity or oropharynx. | 2010 | 21225495 |
| a human papillomavirus 8 e7 protein produced in plants is able to trigger the mouse immune system and delay the development of skin lesions. | we investigated the potential of nicotiana benthamiana to express the e7 protein of human papillomavirus 8 (hpv-8), a paradigm genotype among cutaneous hpvs. the protein, modified in its putative prb-binding domain (e7(qgd)), was transiently expressed in leaves following infiltration with agrobacteria carrying either a binary vector combined with silencing suppressor constructs or replicating tobacco mosaic virus (tmv)-based vectors with different targeting signals. hpv-8 e7(qgd) yields ranged f ... | 2011 | 21234770 |
| diagnosis of anal human papillomavirus infection: polymerase chain reaction or cytology? | to investigate the relationship between human immunodeficiency virus (hiv)-positive and hiv-negative patients engaging in promiscuous behaviors and anal human papillomavirus (hpv) infection diagnosed by polymerase chain reaction (pcr) and cytology. | 2011 | 21239202 |
| molecular pathogenesis of cervical cancer. | cervical cancer is a sexually transmitted disease that results from infection with oncogenic types of human papillomavirus (hpv). oncogenic hpv dna is found in over 95% of invasive cervical cancers worldwide. cervical cancer is a leading cause of cancer deaths in developing countries because of high hpv infection rates and lack of comprehensive cervical pap smear testing of susceptible women. vaccination against hpv prevents the acquisition of cervical dysplastic lesions among eligible women who ... | 2011 | 21239888 |
| human papillomavirus and predictors of cervical intraepithelial neoplasia among young mothers in a prospective follow-up study. | to study the incidence times and rates for cervical intraepithelial neoplasia (cin) and its predictors. | 2010 | 21241262 |
| retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the e7 oncoprotein in hpv 16-positive cells. | "high risk" human papillomavirus strains are the causative agents of the vast majority of carcinomas of the uterine cervix. in these tumors, the physical integration of the hpv genome is a frequent, though not invariable occurrence, but the constitutive expression of the e6 and e7 viral genes is always observed, suggesting key roles for the e6 and e7 oncoproteins in the process of malignant transformation. the "intracellular antibody" technology using recombinant antibodies in single-chain forma ... | 2011 | 21241471 |
| single-tube multiplex pcr using type-specific e6/e7 primers and capillary electrophoresis genotypes 21 human papillomaviruses in neoplasia. | 2011 | 21241508 | |
| detection of human papillomavirus in multiple eccrine poromas in a patient with chronic graft-vs-host disease and immunosuppression. | 2011 | 21242407 | |
| development of a cellular assay system to study the genome replication of high- and low-risk mucosal and cutaneous human papillomaviruses. | we found that recircularized high-risk (type 16 and 18) and low-risk mucosal (type 6b and 11) and cutaneous (type 5 and 8) human papillomavirus (hpv) genomes replicate readily when delivered into u2os cells by electroporation. the replication efficiency is dependent on the amount of input hpv dna and can be followed for more than 3 weeks in proliferating cell culture without selection. cotransfection of recircularized hpv genomes with a linear g418 resistance marker plasmid has allowed subclonin ... | 2011 | 21248030 |
| human papilloma virus infections. | genital warts are believed to be caused by human papilloma viruses and to be sexually transmitted. the viruses are classified by dna types, which appear to cause different types of disease. the choice of treatment, and usually its success rate, vary according to the type of disease and its location. | 1989 | 21248973 |
| prevalence and type distribution of human papillomavirus in healthy japanese women aged 20 to 25 years old enrolled in a clinical study. | efficacy, immunogenicity and tolerability of the human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine were evaluated in japanese women aged 20-25 years, for which results have been reported previously. we analyzed the baseline data from that study and report the prevalence rates of hpv infection in young healthy japanese women. one thousand and the forty japanese women aged 20-25 years were enrolled in a phase ii, double-blind, controlled, randomized, multicenter study. at study entry, cervi ... | 2011 | 21251162 |
| cd40 is overexpressed by hpv16/18-e6 positive cervical carcinoma and correlated with clinical parameters and vascular density. | cd40 is expressed in many tumor cells, however, its role in tumor biology is yet to be demonstrated. in the present study, we investigated the role of cd40 in cervical carcinoma. in vivo, we evaluated cd40 expression in 56 cervical carcinoma tissues, 43 cervicitis and 38 normal cervix, and investigated the relationship between cd40 and hpv antigen, histopathological parameters, vascular density, and vascular endothelial growth factor (vegf) expressions. the results clearly demonstrated that cd40 ... | 2011 | 21251894 |
| estimating the impact of human papillomavirus (hpv) vaccination on hpv prevalence and cervical cancer incidence in mali. | human papillomavirus vaccines have potential to reduce cervical cancer incidence and mortality; however, cultural and economic barriers may hinder success in developing countries. we assessed impact of a single vaccine campaign in mali with use of mathematical modeling. our model shows that decreases in the prevalence of human papillomavirus infection are proportional to achieved vaccination coverage. | 2011 | 21252142 |
| is human papillomavirus screening preferable to current policies in vaccinated and unvaccinated women? a cost-effectiveness analysis. | italy was the first european nation to offer free vaccination against human papillomavirus (hpv) types 16 and 18. the vaccination is actively encouraged and is available free of charge to 11-year-old girls. the introduction of new technologies such as hpv dna testing and hpv vaccination requires cost-effectiveness analysis of cervical cancer strategies in italy for both vaccinated and unvaccinated women. | 2010 | 21258128 |
| stepwise algorithm combining hpv high-risk dna-based assays and rna-based assay for high grade cin in women with abnormal smears referred to colposcopy. | the detection of high-risk human papillomavirus (hpv) dna provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (cin). | 2010 | 21263189 |
| correlates of receiving recommended adolescent vaccines among adolescent females in north carolina. | immunization is a successful and cost-effective method for preventing disease, yet many adolescents do not receive recommended vaccines. we assessed correlates of uptake of three vaccines (tetanus booster, meningococcal, and human papillomavirus [hpv] vaccines) recommended for adolescent females. methods. we examined cross-sectional data from 647 parents of 11-20 year-old females from north carolina who completed the carolina hpv immunization measurement and evaluation (chime) project follow-up ... | 2011 | 21263224 |
| prevalence of human papillomavirus among women with normal cervical cytology in kuwait. | this study was undertaken to determine the prevalence and type specific distribution of human papillomavirus (hpv) in women with normal cervical cytology in kuwait. the study is the first of its type in kuwait and one of few in the middle east. the age specific distribution of hpv types was determined in 3,011 thinprep samples taken from women seeking routine gynaecological care. thinprep samples were screened for hpv dna by real-time pcr. the type specific distribution of the viruses was determ ... | 2011 | 21264866 |
| expression of human papillomavirus 16 e7ggg oncoprotein on n- and c-terminus of potato virus x coat protein in bacterial and plant cells. | the e7 oncoprotein from human papillomavirus type 16 (hpv16) is an attractive candidate for anti-cancer therapeutical vaccine development. in this study, we engineered different fusions of mutagenized coding sequence of e7 oncoprotein (e7ggg) with coat protein of potato virus x (pvx cp) both on 5'- and 3'-terminus of pvx cp and evaluated the influence of the length of linker (no linker, 4, 15aa) connecting pvx cp and e7ggg on their production. at first the expression in escherichia coli was cond ... | 2011 | 21266198 |
| mutants of plant genes for developing cancer vaccines. | preventive human papillomavirus (hpv) vaccination is an expensive practice and it may be an insufficient tool to tackle cervical cancer worldwide. therapeutic intervention is seeking for safe/effective vaccines inducing the activation of cd8+ cytotoxic t lymphocytes (ctls) that is required to clear the tumor. linking a tumor-specific antigen (i.e. the e7 oncoprotein of the 'high risk' hpvs) to molecules able to increase its immune 'visibility' represents a strategy to force the immune system to ... | 2011 | 21266841 |
| phylogeny and polymorphism in the long control region, e6, and l1 of human papillomavirus types 53, 56, and 66 in central brazil. | several studies related that different human papillomavirus (hpv) types and intratype variants can present different oncogenic potential. in opposite to hpvs 16 and 18 variants, information about variants of other carcinogenic hpv types is still scarce. the aim of this study was to investigate the genetic variability of hpvs 53, 56, and 66 from central brazil isolates. | 2011 | 21270605 |
| clinicopathologic implications of the epidermal growth factor receptor, cyclooxygenase 2 expression, and human papillomavirus status in squamous cell carcinoma of the uterine cervix in the elderly. | to find information on invasive squamous cervical carcinoma in the elderly, 110 invasive squamous cervical carcinomas obtained from 2 groups of patients (aged <60 and >60 years) were analyzed for human papillomavirus (hpv) status by polymerase chain reaction study, for immunohistochemical epidermal growth factor receptor (egfr), cyclooxygenase 2 (cox-2) expression, and clinicopathologic features. | 2011 | 21270615 |
| comparison of the diagcor genoflow human papillomavirus array test and roche linear array hpv genotyping test. | persistent infection of high-risk (hr) human papillomavirus (hpv) infection has been widely associated with cervical cancer. monitoring hpv infection is therefore an important step against cervical cancer development. the diagcor genoflow human papillomavirus array test (genoflow) is a novel hpv test based on pcr and "flow-through" hybridization that can identify 33 hpv subtypes in 3 hours. in the present study, the genoflow test was evaluated by comparing the genotyping results of 100 samples w ... | 2010 | 21270940 |
| automated high throughput dna isolation for detection of human papillomavirus in oral rinse samples. | oral hpv infection elevates risk of oropharyngeal cancer, but its natural history is unknown. natural history studies necessitate validation of an automated, high-throughput method for hpv genomic dna detection in oral rinse samples (ors). | 2011 | 21273118 |
| intradermal injection of ppd as a novel approach of immunotherapy in anogenital warts in pregnant women. | immunotherapy for treatment of recalcitrant warts was used through different modalities including intralesional injection of purified protein derivative (ppd), which is an extract of mycobacterium tuberculosis, used for testing exposure to tuberculin protein, either from a previous vaccination or from the environment. this method is used to evaluate the efficacy of a new approach of intradermal injection of ppd in the treatment of anogenital warts in pregnant women. a total of 40 pregnant women, ... | 2011 | 21276168 |
| considerations for human papillomavirus (hpv) vaccination of mid-adult women in the united states. | in the united states, human papillomavirus (hpv) vaccination is recommended for 11 or 12 year old girls, with catch-up vaccination through age 26 years. data are available for women over the age of 26 years on immunogenicity for both quadrivalent and bivalent hpv vaccines and on efficacy for the quadrivalent hpv vaccine. if hpv vaccines are licensed for use in women over 26 years of age (mid-adult women), recommendations for this age group will need to be considered. this review summarizes vacci ... | 2011 | 21277406 |
| what is your diagnosis? bowenoid papulosis. | 2010 | 21284277 | |
| prevalence of human papillomavirus genotypes in cytologic abnormalities from unvaccinated women living in north-western spain. | cervical cancer and its precursors low-grade squamous intraepithelial lesions (lsil) and high-grade squamous intraepithelial lesions (hsil) are associated with infection by human papillomavirus (hpv), in particular hpv 16 and 18. the distribution of the hpv genotype varies with the severity of cervical disease, age and the geographic location of the patients. we report the results of a population study carried out in a region of north-western (nw) spain aimed at determining the prevalence of sin ... | 2011 | 21284738 |
| safety of the hpv bivalent and quadrivalent vaccines during pregnancy (february). | objective: to evaluate the safety of the human papillomavirus (hpv) bivalent and quadrivalent vaccines in pregnancy. data sources: pubmed (1966-august 2010) was searched using the terms human papillomavirus, human papillomavirus vaccine, and pregnancy. references were reviewed for relevant information. study selection and data extraction: all studies including humans that were published in english with data describing hpv vaccine administration in pregnancy were evaluated. data synthesis: two co ... | 2011 | 21285408 |
| health-related quality of life in indian patients with three viral sexually transmitted infections: herpes simplex virus-2, genital human papilloma virus and hiv. | health-related quality of life (hrqol) has not been studied in indian patients with viral sexually transmitted infections (stis): herpes simplex virus-2 (hsv-2) and genital human papilloma virus (hpv) infections. furthermore, there is no reported study that compares hrqol among these two viral stis and hiv. | 2011 | 21289022 |
| decision-analytic modeling to evaluate the long-term effectiveness and cost-effectiveness of hpv-dna testing in primary cervical cancer screening in germany. | persistent infections with high-risk types of human papillomavirus (hpv) are associated with the development of cervical neoplasia. compared to cytology hpv testing is more sensitive in detecting high-grade cervical cancer precursors, but with lower specificity. hpv based primary screening for cervical cancer is currently discussed in germany. decisions should be based on a systematic evaluation of the long-term effectiveness and cost-effectiveness of hpv based primary screening. | 2010 | 21289878 |
| assessment of effectiveness and cost-effectiveness of hpv testing in primary screening for cervical. | the introduction of a screening programme for cervical carcinoma in germany has led to a significant reduction in incidence of the disease. to date, however, diagnosis in germany has been based solely on cervical cytology, which has been criticised because of a low sensitivity and consequently high rate of false negative results. because an infection with the human papillomavirus (hpv) previously was found to be a necessary aetiological factor in the development of cervical cancer, there has bee ... | 2007 | 21289942 |
| biphasic vesicles for topical delivery of interferon alpha in human volunteers and treatment of patients with human papillomavirus infections. | purpose. topical biphasic vesicle delivery system encapsulating interferon alpha (ifn a) was developed as an alternative to injections used to treat human papillomavirus (hpv) infections. methods. biphasic lipid vesicles encapsulating increasing doses of ifn a (biphasic ifn a) were characterized for encapsulation efficiency, size, zeta potential and vesicle structure by centrifugation, dynamic light scattering, confocal microscopy and small-angle x-ray scattering. biphasic ifn-a delivery into hu ... | 2011 | 21291377 |
| human papillomavirus infection in women with and without cervical cancer in tbilisi, georgia. | background: no accurate estimates of cervical cancer incidence or mortality currently exist in georgia. nor are there any data on the population-based prevalence of high-risk (hr) human papillomavirus (hpv) infection, which, in the absence of good-quality screening, is known to correlate with cervical cancer incidence. methods: we obtained cervical cell specimens from 1309 women aged 18-59 years from the general population of tbilisi, and also from 91 locally diagnosed invasive cervical cancers ... | 2011 | 21292583 |
| distribution of human papillomavirus load in clinical specimens. | the information about the range and distribution of human papillomavirus load in clinical specimens is important for the design of accurate clinical tests. the amount of human papillomavirus in cervical specimens was estimated using the digene hc2 hpv dna test(®) (qiagen). this semi-quantitative assay is based on linear signal amplification with an analytical limit-of-detection of approximately 2500 virus copies per assay and 3-4 log dynamic range. the dynamic range of the assay was extended by ... | 2011 | 21295613 |
| frequency of human papillomavirus infection, coinfection, and association with different risk factors in colombia. | the aims of this study were to provide new insights into infection patterns of six high-risk human papillomaviruses (hr-hpv-16, -18, -31, -33, -45, and -58) and two low-risk hpv types (lr-hpv-6 and -11), their association with risk factors and coinfection. | 2011 | 21296271 |
| bd-proexc as adjunct molecular marker for improved detection of cin2+ after hpv primary screening. | we investigated the efficacy of 8 cervical cancer screening strategies relative to cytology with emphasis on immunocytochemical detection of high-risk human papillomavirus (hrhpv)-induced cell transformation (bd-proexc) as a tool of triage following primary cytology or hrhpv testing. 3,126 women were tested with bd-surepath liquid-based cytology, hrhpv pcr genotyping and bd-proexc immunostaining, and colposcopy verification to calculate sensitivity and positive predictive value (ppv) in detectin ... | 2011 | 21297040 |
| distribution of hpv genotypes in women with cervical cancer in auckland, new zealand; a review of 50 specimens between 2000-2006. | in new zealand, around two hundred women are diagnosed with cervical cancer annually, with approximately seventy deaths from cervical cancer per year. | 2010 | 21299512 |
| text message reminders to promote human papillomavirus vaccination. | to implement and evaluate text message reminders for the second (hpv2) and third (hpv3) vaccine doses. | 2011 | 21300094 |
| the hpv vaccine: are dosing recommendations being followed? | the aims of this study were to determine the percentage of females who after initiating the human papillomavirus (hpv) vaccine series, both completed it and completed it on-time, as well as to examine factors associated with series completion and on-time completion. using data from the north carolina immunization registry, of 138,823 females analyzed, 55% completed the series, and 28% completed it on-time. over 83% of those who initiated the vaccine series in 2006 completed it by the final study ... | 2011 | 21300098 |
| awareness and knowledge about human papillomavirus among latina immigrants. | few studies have examined associations with the public's awareness and knowledge of the human papillomavirus (hpv) among latina immigrants. the primary purpose of this study was to assess hpv awareness and knowledge, while examining demographic and healthcare utilization associations. | 2010 | 21305817 |
| women's sexual behavior. population-based study among 65,000 women from four nordic countries before introduction of human papillomavirus vaccination. | sexual behavior is of public health interest because of the association with reproductive health and sexually transmitted infections such as human papillomavirus, which is the causal factor of cervical cancer. the aim of the study was to describe patterns in women's sexual behavior in four nordic countries. | 2011 | 21306319 |
| lack of hpv 16 and 18 detection in serum of colposcopy clinic patients. | persistent infection with high-risk human papillomavirus (hpv) types is necessary for the development of high-grade cervical dysplasia and cervical carcinoma. the presence of hpv dna in the blood of cervical cancer patients has been reported; however, whether hpv dna is detectable in the blood of patients with pre-invasive cervical disease is unclear. | 2011 | 21306941 |
| human papillomaviruses prevalence and genital co-infections in hiv-seropositive women in ouagadougou (burkina faso). | the vaginal swabs among hiv-positive women in africa often revealed opportunistic infections such as human papillomavirus (hpv) and mycoplasma that induce respectively cervix cancer and diseases such as vaginosis, abortions, infertility in through salpingitis. the purposes of this study were to: (1) seek for, the prevalence of pathogens such as hpv and mycoplasma; (2) characterize the strains of hpv and estimate their prevalence; (3) identify among these women, those who were co-infected by thes ... | 2010 | 21313918 |
| acceptability of human papillomavirus vaccine among the urban, affluent and educated parents of young girls residing in kolkata, eastern india. | aim: the human papillomavirus (hpv) vaccine is recommended for adolescent girls and young women; however, the social structure in india will not permit vaccination of this age-group without parental approval. our study aimed to explore the attitude of affluent, urban indian parents towards the hpv vaccine. methods: well-to-do married couples with at least one daughter between 9-26 years of age were interviewed using a questionnaire in two parts. the first part was to assess their attitude to v ... | 2011 | 21314807 |
| biomarker expression in cervical intraepithelial neoplasia: potential progression predictive factors for low-grade lesions. | the aim of this study was to reveal whether 3 biomarkers (p16ink4a, proex c, and human papilloma virus dna) are useful in the diagnosis of cervical intraepithelial neoplasia and whether they could predict disease progression of cervical intraepithelial neoplasia-1. we analyzed 252 cervical specimens: nondysplastic mucosa (n = 9), cervical intraepithelial neoplasia (n = 229), and squamous cell carcinoma (n = 14). immunostaining for p16ink4a and proex c, and the hybridcapture ii assay for human pa ... | 2011 | 21315414 |
| survival and human papillomavirus in oropharynx cancer in tax 324: a subset analysis from an international phase iii trial. | the association between human papillomavirus (hpv) and overall survival (os) in oropharynx cancer (opc) was retrospectively examined in tax 324, a phase iii trial of sequential therapy for locally advanced head and neck cancer. | 2011 | 21317223 |
| the role of human papillomavirus infection in breast cancer. | breast cancer is the leading female cancer and the third most common cause of cancer deaths worldwide. many studies have suggested a possible link between breast cancer pathogenesis and viral infection, particularly mouse mammary tumour virus, simian virus 40, epstein-barr virus, and human papillomavirus (hpv). a significant number of recent studies have reported that approximately 29% of human breast cancer tissues were positive for high-risk hpv subtypes, especially hpv subtypes 16, 18, or 33. ... | 2011 | 21318737 |
| identification of key amino acid residues that determine the ability of high risk hpv16-e7 to dysregulate major histocompatibility complex class i expression. | high risk human papillomavirus (hpv) types are the major causative agents of cervical cancer. reduced expression of major histocompatibility complex class i (mhc i) on hpv-infected cells might be responsible for insufficient t cell response and contribute to hpv-associated malignancy. the viral gene product required for subversion of mhc i synthesis is the e7 oncoprotein. although it has been suggested that high and low risk hpvs diverge in their ability to dysregulate mhc i expression, it is no ... | 2011 | 21321113 |
| comparison of hpv genotyping assays and hybrid capture 2 for detection of high-risk hpv in cervical specimens. | high-risk types of human papillomavirus (hr-hpv) are among the primary causes of cervical cancers. hybrid capture 2 (hc-ii) (digene, gaithersburg, md), which detects 13 hr-hpvs as a group, is the only hpv assay approved to date by the united states food and drug administration. in korea, several hpv genotyping assays are commercially available, including hpv rfmp (genematrix co., seoul), hpvdnachip (biomedlab co., seoul), and myhpv chip (mygene co., seoul). we compared the results of these assay ... | 2011 | 21325255 |
| rapid genotyping of human papillomavirus by post-pcr array-based hybridization techniques. | kinetic hybridization measurements on a microarray are expected to become a valuable tool for genotyping applications. a method has been developed that enables kinetic hybridization measurements of pcr products on a low-density microarray. this is accomplished by pumping a solution containing pcr products up and down through a porous microarray substrate. after every pumping cycle, the fluorescently labeled pcr products hybridized to capture probes immobilized on the solid surface of the porous ... | 2011 | 21325552 |
| prevalence and clinical features of human papillomavirus in head and neck squamous cell carcinoma in okinawa, southern japan. | previous studies from okinawa, a subtropical island in southern japan, demonstrated a higher prevalence of human papillomavirus (hpv) in oral carcinoma and a higher incidence of oral and pharyngeal carcinoma than those for mainland japan. the present study aims to investigate epidemiologic and clinical features of hpv in head and neck squamous cell carcinoma (hnscc) in okinawa. a total of 150 dna samples from 150 okinawan patients with head and neck squamous cell carcinoma (hnscc) were screened ... | 2011 | 21328000 |
| casp8 promoter polymorphism is associated with high-risk hpv types and abnormal cytology but not with cervical cancer. | only a small fraction of women infected with human papillomavirus (hpv) progress to cervical cancer pointing to additional risk factors including host genetics that might play a role in development of cervical cancer. caspase-8 (encoded by casp8 gene) is crucial in generating cell death signals to eliminate potentially malignant cells. genetic variation in casp8 might influence the susceptibility to cancer. casp8 -652 6n ins/del polymorphism has been previously reported to influence the progress ... | 2011 | 21328377 |
| hpv types and variants among cervical cancer tumors in three regions of tunisia. | cervical cancer is the second most common cancer among tunisian women, and the incidence rates vary by region. three tunisian registries report age-standardized rates of 6.3/10(5) in the central region, 5.4/10(5) in the north, and 2.7/10(5) in the south. high-risk human papillomavirus (hpv) types and their variants differ in carcinogenic potential and geographic distribution. the hpv type and variant distribution could be a factor in the differing rates between regions of tunisia. tumor tissue w ... | 2011 | 21328380 |
| oral lichen planus: malignant transformation and human papilloma virus: a review of potential clinical implications. | oral lichen planus (olp) occurs in from 2% to 3% of the population and may have a risk of malignant transformation into squamous cell carcinoma (scc). this risk is not necessarily associated with exposure to tobacco and alcohol. an increased awareness of a possible role of human papilloma virus (hpv) and scc led us to review a possible association between this virus infection and malignant transformation of olp. the possible linkage between hpv and the risk of transformation of olp to malignancy ... | 2011 | 21330164 |
| survivin and telomerase expression in the uterine cervix of women with human papillomavirus-induced lesions. | infection by human papillomavirus is the most important risk factor in the pathogenesis of uterine cervical cancer. the aims of this study were to evaluate the expression of survivin protein and telomerase enzyme in samples of uterine cervix from women with human papillomavirus-induced lesions and to determine the relationship between survivin and telomerase expression and the different grades of cervical squamous intraepithelial neoplasia and invasive cervical carcinoma. | 2011 | 21330827 |
| cost-consequences evaluation between bivalent and quadrivalent hpv vaccines in italy: the potential impact of different cross-protection profiles. | two human papillomavirus (hpv) vaccines are currently available: a bivalent hpv-16/18 and a quadrivalent hpv-6/11/16/18 vaccine. the vaccines may have different sustained- and cross-protection levels against non-vaccine oncogenic hpv-types. this study investigated the potential difference in clinical and economic impacts provided by two hpv vaccines in italy. | 2011 | 21334734 |
| koilocytes are enriched for alkaline-labile sites. | this study investigated possible variations in the chromatin structure of koilocytes resulting from human papillomavirus (hpv) infection. alkaline-labile sites (als) were detected with the dna breakage detection–fluorescence in situ hybridization (dbd-fish) technique using a whole human genome dna probe obtained from individuals without koilocytosis. the variable levels of als present were measured quantitatively using image analysis after whole-genome dna hybridization. a significant increase i ... | 2010 | 21337807 |
| prevalence of high-risk human papillomavirus infection and cytologic results in thailand. | cervical cancer is the second most common female cancer with a high mortality rate. the established cause is high-risk types of human papillomavirus (hpv) and a new modality for cervical cancer screening is the combination of cervical cytology with hpv testing. the aim of present study was to identify the prevalence of high-risk hpv infection, and cervical cytological profiles of healthy thai women. this largest cross-sectional investigation of hpv testing so far with cytology screening in thail ... | 2010 | 21338181 |
| perceptions and opinions regarding human papilloma virus vaccination among young women in malaysia. | the objective of this study is to explore the perceptions and opinions of young women about human papilloma virus (hpv) vaccination and associated barriers. | 2010 | 21338190 |
| assessing the role of education on turkish university students' knowledge about hpv and related diseases. | human papillomavirus (hpv) is one of the most common sexually transmitted causes of infections and adolescents are at high risk. the aim of the study was to evaluate university students' hpv knowledge before and after educational intervention on hpv. | 2010 | 21338219 |
| human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and african americans. | to evaluate the frequency of human papillomavirus-related oropharyngeal squamous cell carcinoma in african americans and whites and to examine patient outcomes in these 2 groups. | 2011 | 21339403 |
| molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in turkish pregnants. | human cytomegalovirus (cmv) is the most common cause of viral intrauterine infections in the world. herpes simplex virus type 2 (hsv-2) and human papillomavirus (hpv) are the main agents of viral sexually transmitted diseases, which cause genital ulcers and genital warts, respectively. hpv infection has been linked to the majority of the anogenital malignancies. the aim of this study was to detect the existence of cmv, hsv-2 and hpv type 16-18 in turkish pregnants by using sensitive molecular as ... | 2010 | 21340297 |
| completion of the human papillomavirus vaccine series in females attending an urban immunization clinic. | this project characterized the extent to which women and girls who initiated human papillomavirus vaccination between 2007 and 2009 at the baltimore city health department completed the full vaccine series, and reasons for failure to follow-up. more than 85% of girls and women had an incomplete series, and it was not possible to reach 80% of these girls and women using the phone number provided. those who were contacted reported not knowing they needed further doses, having forgotten, being too ... | 2011 | 21343841 |
| high-risk human papillomavirus testing in women with asc-us cytology: results from the athena hpv study. | this study evaluated the clinical performance of the cobas 4800 hpv test (roche molecular systems, pleasanton, ca) for high-risk human papillomavirus (hr-hpv) testing with individual hpv-16/hpv-18 genotyping in women 21 years or older with atypical squamous cells of undetermined significance (asc-us). women (n = 47,208) were recruited in the united states during routine screening, and liquid-based cytology and hpv testing were performed. the asc-us prevalence was 4.1% (1,923/47,208), and 1,578 w ... | 2011 | 21350104 |
| potentiation of tumor radiotherapy by a radiation-inducible oncolytic and oncoapoptotic adenovirus in cervical cancer xenografts. | the p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result of infection by human papillomavirus (hpv). the hpv e6 oncoprotein forms complexes with p53 and promotes its degradation via ubiquitin-dependent mechanism. in our study, we attempted to improve the clinical outcomes of this combined therapy by modifying the p53-targeted adenovirus to become radiation-responsive. the antitumor adenovirus was constructed by inserting a radiat ... | 2011 | 21351100 |
| self-collected human papillomavirus testing acceptability: comparison of two self-sampling modalities. | human papillomavirus (hpv) testing can be used as a primary test for cervical cancer screening. hpv self-sampling has the potential to replace physician/nurse sampling. our objective was to compare the acceptability of two self-sampling methods among 205 women undergoing an excisional procedure for cervical intraepithelial neoplasia (cin) at the european institute of oncology (ieo). | 2011 | 21351869 |
| oral zinc sulfate treatment for viral warts: an open-label study. | viral warts, which are caused by the human papilloma virus, are a common problem in dermatology. various modalities have been used to treat warts, but none are uniformly effective or directly antiviral. recent studies show that oral zinc sulfate could be effective in the treatment of viral warts. thirty-one patients with multiple, non-genital viral warts were recruited in this open-label clinical study. the patients were treated with oral zinc sulfate (10 mg/kg to a maximum dose of 600 mg/day) f ... | 2010 | 21352302 |
| human papillomavirus detection in moroccan patients with nasopharyngeal carcinoma. | 2011 | 21352537 | |
| immortalisation of normal human urothelial cells compromises differentiation capacity. | the development of urothelial malignancy is not solely a consequence of loss of proliferation constraints but also involves loss of cellular differentiation, defined histopathologically as grade. although tumour grade is an independent prognostic marker for urothelial carcinoma (uc), the molecular events underpinning the loss of urothelial differentiation are poorly understood. | 2011 | 21353380 |
| clinical experience with the cervista hpv hr assay: correlation of cytology and hpv status from 56,501 specimens. | testing for high-risk (hr) human papillomavirus (hpv) is a key component of current recommendations for cervical cancer screening. herein is described our clinical experience using cervista hpv hr, a testing platform recently approved by the us food and drug administration for clinical use. using data from a high-volume commercial laboratory, a retrospective analysis of cytologic and cervista hpv hr test results from 56,501 samples was performed, and an indirect comparison was made with previous ... | 2011 | 21354050 |
| for cancers caused by hpv, two vaccines were just the beginning. | 2011 | 21357595 | |
| epidermal growth factor genetic variation associated with advanced cervical cancer in younger women. | objectives: epidermal growth factor (egf) stimulates cell proliferation by binding to its receptor (epidermal growth factor receptor), and the overexpression of this receptor is associated with poorer prognosis. the egf gene presents a polymorphism at position 61 (a/g), associated with higher egf production. we examined the association between this polymorphism and cervical cancer through a case-control study. methods: this study used the pcr-restriction fragment length polymorphism method on a ... | 2011 | 21358296 |
| prevalence of cervical human papillomavirus infection among married women in hanoi, vietnam, 2010. | human papillomavirus (hpv) is a necessary cause of cervical cancer. this study examined the prevalence of cervical hpv infection and the distribution of hpv specific types among married women in hanoi to provide updated data for planning cancer preventive activities. sample of 750 married women aged 15 to 69 years were interviewed and had gynecological examination. hpv infection status and hpv genotyping tests were done for all participants. results: indicated that the prevalence of cervical hpv ... | 2011 | 21362673 |
| haart and progression to high-grade anal intraepithelial neoplasia in men who have sex with men and are infected with hiv. | human immunodeficiency virus (hiv)-seropositive men who have sex with men (msm) are at risk for anal intraepithelial neoplasia (ain) and cancer. the goal of this study was to identify risk factors associated with high-grade ain (ain-2,3) in hiv-positive msm, including the receipt of highly active antiretroviral therapy (haart). | 2011 | 21364075 |
| human papillomavirus vaccination in males: the state of the science. | human papillomavirus (hpv) is an extremely prevalent sexually transmitted infection that is typically acquired soon after onset of sexual activity. the burden of hpv-related malignant and nonmalignant disease is high in men and women. high-risk or oncogenic types of hpv cause cervical, vaginal, and vulvar cancer in women. these types have also been shown to cause penile cancer in men and a substantial proportion of oropharyngeal and anal malignancy in men and women. low-risk types of hpv cause a ... | 2011 | 21365381 |
| performance of p16ink4a immunocytochemistry as a marker of anal squamous intraepithelial lesions. | protein p16(ink4a) immunocytochemistry (iccp16) has the potential to reveal lesions at risk of progression to anal cancer. this study examined measures of diagnostic validity of iccp16 in hiv-positive patients treated at the tropical medicine foundation of amazonas in the coloproctology outpatient clinic. | 2011 | 21365778 |
| treatment of a human papillomavirus type 31b-positive cell line with benzo[a]pyrene increases viral titer through activation of the erk1/2 signaling pathway. | numerous epidemiological studies have implicated cigarette smoking as a cofactor in the progression to cervical cancer. tobacco-associated hydrocarbons have been found in cervical mucus, suggesting a possible interaction with human papillomavirus (hpv)-infected cells. the polycyclic aromatic hydrocarbon benzo[a]pyrene (bap) is a major component of cigarette smoke condensate that has received significant attention due to its ability to induce carcinogenesis. we have previously demonstrated by con ... | 2011 | 21367897 |
| new indication approved for hpv vaccine. | 2011 | 21370548 | |
| human papillomavirus and cervical neoplasia among female sex workers in madagascar. | human papillomavirus (hpv) prevalence and type distribution were estimated among 90 female sex workers (fsws) aged 18 to 58 years in antananarivo, madagascar. | 2010 | 21370602 |
| update on available vaccines in india: report of the appa vu 2010: i. | the asia pacific pediatric association vaccinology update 2010 was held in mumbai on november 13-14, 2010 to discuss the latest information on burden of infectious diseases, recent developments in vaccines and their impact on immunization practices against infectious diseases occurring in indian children. during the conference the importance of including conjugate haemophilus influenzae type b vaccine and anti-rabies vaccines in routine immunization was stressed. also, the need for giving a seco ... | 2011 | 21373831 |
| prevalence of anal intraepithelial neoplasia defined by anal cytology screening and high-resolution anoscopy in a primary care population of hiv-infected men and women. | prevalence of high-grade anal intraepithelial neoplasia, the human papillomavirus-associated putative anal cancer precursor, is high in hiv-infected men who have sex with men, but less is known about its prevalence in other hiv-infected subgroups. similarly, the prevalence of abnormal cytology, used as a screen, is not well-defined in these subgroups. | 2011 | 21383563 |
| lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | lymphoepithelioma-like carcinoma (lelc) in the urinary tract is a rare malignancy, named for its resemblance to nasopharyngeal undifferentiated carcinoma or lymphoepithelioma. investigation of immunohistochemical and molecular characteristics of bladder lelc is limited. the pathogenesis and biological behavior of these tumors are controversial. | 2011 | 21383609 |
| cancer vaccine boosted by infrastructure for hiv care in africa. | 2011 | 21383729 | |
| looking ahead: a case for human papillomavirus testing of self-sampled vaginal specimens as a cervical cancer screening strategy. | even in the era of highly effective human papillomavirus (hpv) prophylactic vaccines, substantial reduction in worldwide cervical cancer mortality will only be realized if effective early detection and treatment of the millions of women already infected and the millions who may not receive vaccination in the next decade can be broadly implemented through sustainable cervical cancer screening programs. effective programs must meet three targets: (i) at least 70% of the targeted population should ... | 2011 | 21384341 |
| mitochondrial c150t polymorphism increases the risk of cervical cancer and hpv infection. | during a survey of control region (d-loop) sequence variances in 142 cervical cancer (cc) patients and 136 controls, all chinese women, including both hpv-positive (human papillomavirus) and hpv-negative subjects, we determined that the c150t polymorphism increased the cc risk in a case-control study (or=3.0, 95% ci=1.8-5.0, p<0.05). hpv-positive individuals were more likely to carry the c150t polymorphism than hpv-negative controls (or=5.8, 95% ci=2.6-13.2, p=2.3+ù10(-5)). hpv-positive cc patie ... | 2011 | 21385627 |
| the burden of cervical cancer in china: synthesis of the evidence. | the burden of cervical cancer in china has not been characterized in detail. we reviewed cervical cancer data from national mortality surveys and registries, and conducted a meta-analysis to estimate the prevalence of high-grade lesions (hsil) and high-risk human papillomavirus (hr-hpv) infections in rural shanxi province. we found that a national survey in the 1970s estimated age-standardized cervical cancer mortality rates as ôê+15 and ôê+83/100,000 women nationally and in xiangyuan, shanxi; b ... | 2011 | 21387308 |
| combined promoter methylation analysis of cadm1 and mal: an objective triage tool for high-risk human papillomavirus dna-positive women. | screening women for high-grade cervical intraepithelial neoplasia or cervical cancer (cin3(+)) by high-risk human papillomavirus (hrhpv) testing has as side-effect the detection of hrhpv-positive women without clinically relevant lesions. here, we developed an objective assay assessing the methylation status of the promoter regions of cadm1 and mal to triage hrhpv-positive women for cin3(+). | 2011 | 21389098 |
| factors associated with intention to vaccinate a daughter against hpv: a statewide survey in alabama. | human papillomavirus (hpv) is the most common sexually transmitted infection in the united states. adolescent and young adults aged 15-24 were estimated to account for three quarters of new infections in 2000. two hpv vaccines are currently available. the vaccine is recommended for girls aged 11-12 years. previous research has indicated that african-american and asian-american parents are less likely than caucasians to vaccinate their daughters. this investigation examines the relationship betwe ... | 2011 | 21397534 |
| human papillomavirus 16 or 18 infection and prostate cancer risk: a meta-analysis. | whether the oncogenic human papillomavirus (hpv) infection, especially infection with the most common subtypes 16 or 18, is related to prostate carcinogenesis remains conflicting. a meta-analysis with updated data was performed to obtain a more precise estimate of the association between them. | 2011 | 21400096 |
| [morphological and immunohistochemical studies of palatine tonsillar hypertrophy in children]. | the paper presents the results of immunohistochemical and morphometric studies conducted to examine an association of the site, the expression of virus antigens, and the nature of morphological changes in the hypertrophic palatine tonsils in children. the distribution of cd3+ and cd20+ cells was explored in tonsillar tissue. the greatest changes were shown in the epithelium, the antigens of herpex simplex virus being more frequently detected than those of human papillomavirus. the presented data ... | 2010 | 21400774 |
| multiple human papillomavirus infections: the exception or the rule? | 2011 | 21402540 | |
| human papillomavirus infection with multiple types: pattern of coinfection and risk of cervical disease. | we investigated coinfection patterns for 25 human papillomavirus (hpv) types and assessed the risk conferred by multiple hpv types toward cervical disease. | 2011 | 21402543 |
| human papillomavirus in head and neck cancers: biology, prognosis, hope of treatment, and vaccines. | human papillomaviruses (hpvs), especially type 16, are implicated in the development of a subset of head and neck squamous cell cancers (hnsccs). this subset of oropharyngeal cancers possesses distinct clinical and laboratory features and outcome, and is particularly common in individuals who lack the traditional risk factors of tobacco and alcohol abuse. moreover, the annual incidence of hpv-related hnsccs has increased in the usa and europe in the last few years. as hpv-associated hnsccs share ... | 2011 | 21403517 |
| alternative her/pten/akt pathway activation in hpv positive and negative penile carcinomas. | the pathogenesis of penile squamous cell carcinoma (pscc) is not well understood, though risk factors include human papillomavirus (hpv). disruption of her/pten/akt pathway is present in many cancers; however there is little information on its function in pscc. we investigated her family receptors and phosphatase and tension homolog (pten) in hpv-positive and negative pscc and its impact on akt activation using immunohistochemistry and fluorescent in situ hybridisation (fish). | 2011 | 21407808 |
| mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa. | human papillomaviruses (hpvs) are agents of the most common sexually transmitted diseases in females and males. precise data about the presence, mechanism of infection and clinical significance of hpv in the male reproductive tract and especially in sperm are not available. here we show that hpv can infect human sperm, it localizes at the equatorial region of sperm head through interaction between the hpv capsid protein l1 and syndecan-1. sperm transfected with hpv e6/e7 genes and sperm exposed ... | 2011 | 21408100 |
| human papillomavirus's physical state and cyclin a1 promoter methylation in cervical cancer. | cervical cancer is the second biggest cause of death among human female cancers. human papillomavirus (hpv) is the main factor in this cancer, especially hpv types 16 and 18, which constitute the high-risk group. there are 2 physical states of hpv in host cells: integrated and episomal forms. our previous study explored the very high degree of cyclin a1 (ccna1) promoter methylation in invasive cervical cancer in which all cases were infected by hpv. | 2011 | 21412159 |
| risk factors for hpv infection among american indian and white women in the northern plains. | american indian (ai) women living in the northern plains have high incidence and mortality rates for cervical cancer. we assessed risk factors for human papillomavirus (hpv) infection among ai and white women. | 2011 | 21414655 |
| a novel real-time genotyping assay for detection of the e6-350g hpv 16 variant. | it has been suggested that some e6 human papillomavirus (hpv) type 16 variants could be involved in viral persistence and progression of hpv infection. a novel one-step allelic discrimination real-time pcr was evaluated for e6-350g variant detection in 102 endocervical hpv 16 positive samples. this assay was also used to assess the distribution of this variant in spanish women with cervical cancer related to hpv 16. the detection limit for the allelic discrimination assay was 50 copies per react ... | 2011 | 21419166 |
| ki-67 and proexc are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia. | esophageal squamous intraepithelial neoplasia has been widely recognized as a precursor lesion for esophageal squamous cell carcinoma. early detection offers the best prognosis for esophageal squamous cell carcinoma. the differentiation of squamous dysplasia from reactive change and the classification of squamous dysplasia into high-grade or low-grade are sometimes subjective and challenging. in this study, we sought to evaluate multiple biomarkers and to develop clinically useful adjunct tools ... | 2011 | 21420715 |
| the impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2-3. | 15-30% of cases of cervical intraepithelial neoplasia grades 2-3 (cin2-3) detected in punch biopsies regress spontaneously (ie, show cin1 or less in the follow-up cone). epithelial retinoblastoma protein (prb), tumour suppressor protein (p53), hpv genotype and immunoreactive cells have been reported to be helpful in predicting regression but their interaction in regression prediction is unknown. | 2011 | 21421698 |