Publications

microbiological properties of a new cephalosporin, bl-s 339: 7-(phenylacetimidoyl-aminoacetamido)-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)ceph-3-em-4-carboxylic acid.	bl-s 339 is a new broad-spectrum, parenterally effective cephalosporin whose expression of antibacterial activity in vitro is markedly affected by the nature of the assay medium. when assayed in nutrient agar, bl-s 339 was more active than cephalothin against strains of diplococcus pneumoniae, streptococcus pyogenes, escherichia coli, serratia marcescens, klebsiella pneumoniae, enterobacter, and indole-positive proteus sp. however, when assayed in mueller-hinton medium, its activity, especially ...	1973	4790575
in vitro bactericidal effectiveness of four aminoglycoside antibiotics.	the antibacterial activity of four aminoglycoside antibiotics (gentamicin, sch 13706, tobramycin, and sisomicin) was tested against eight gram-negative and three gram-positive species. a total of 323 strains were studied by the broth dilution technique. tobramycin and sisomicin had greater bacteriostatic and bactericidal activity against pseudomonas strains than did gentamicin and sch 13706. of the four antibiotics, sisomicin was most active against klebsiella, enterobacter, escherichia coli, in ...	1973	4790579
clinical and in vitro evaluation of cefazolin, a new cephalosporin antibiotic.	cefazolin sodium, a cephalosporin for parenteral use, was evaluated in vitro and in 26 patients. cefazolin had activity equivalent to cephalothin against streptococcus pneumoniae, staphylococcus aureus, group a streptococci, and proteus mirabilis. cefazolin was four- to eightfold more active against escherichia coli and slightly more active against klebsiella pneumoniae, whereas cephalothin was slightly more active against indole-positive proteus species. after a 500-mg dose of cefazolin intramu ...	1973	4790584
cephamycins, a new family of beta-lactam antibiotics: antibacterial activity and resistance to beta-lactamase degradation.	the susceptibility to some cephalosporin antibiotics and to cephamycin c, a member of a new family of beta-lactam antibiotics, was evaluated for 466 cultures representing 11 different genera or species of gram-negative clinical isolates. the susceptibility of 39 gram-negative cultures known to produce beta-lactamase was also determined. the beta-lactamase activity of a representative group of the clinical isolates and the 39 enzyme producers was studied with the cephalosporins (cephalothin and c ...	1973	4790591
evaluation of cefazolin, a new cephalosporin antibiotic.	cefazolin sodium was tested in vitro against 308 isolates of enterobacteriaceae, pseudomonas aeruginosa, neisseria meningitidis, haemophilus influenzae, staphylococcus aureus, and enterococcus. broth and agar dilution and disk diffusion techniques were used with at least two sizes of inocula of organisms. cefazolin was also studied in the treatment of 85 hospitalized patients with a variety of serious infections. in concentations of 5 mug or less/ml, cefazolin inhibited and killed more than 90% ...	1973	4790605
antibacterial activity of cefamandole, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cephalexin.	the in vitro antibacterial activity of cefamandole, a new cephalosporin antibiotic, was compared with that of cephaloridine, cephalothin, and cephalexin against 1,213 strains of gram-positive and gram-negative bacteria recently isolated from clinical sources. the decreasing order of activity of the four agents against gram-positive cocci was cephaloridine, cephalothin, cefamandole, and cephalexin. however, cefamandole was the most active of the four against haemophilus species and gram-negative ...	1973	4790616
in vitro studies of bb-k8, a new aminoglycoside antibiotic.	bb-k8, an aminoglycoside antibiotic which is a derivative of kanamycin, was tested in vitro against 466 clinical bacterial isolates. over 90% of gram-negative bacilli, except proteus spp., were inhibited by 3.12 mug of bb-k8 per ml. this antibiotic was consistently more active than kanamycin but less active than tobramycin or gentamicin. unlike kanamycin, bb-k8 was active against pseudomonas aeruginosa. eleven of 19 isolates resistant to either gentamicin or tobramycin, or both, were susceptible ...	1973	4790938
compound 64716, a new synthetic antibacterial agent.	compound 64716, 1-ethyl-4 (1h)-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid, is a new synthetic antibacterial agent. the antibacterial spectrum of this compound includes gram-negative bacteria that are most frequently isolated from urinary tract infections. minimal inhibitory concentration values of 64716 for isolates of escherichia coli and proteus sp. ranged from 2 to 4 and 2 to 8 mug/ml, respectively, and the compound was bactericidal at concentrations close to the minimal inhibitory co ...	1973	4791302
ticarcillin therapy of infections.	ticarcillin was administered as initial therapy during 73 episodes of infections occurring in 69 adults with neoplastic diseases. during the first six infections, doses of 5 gm were dissolved in 200 ml of solvent and administered intravenously over a 2-h period every 6 h. four of six infections responded to therapy. however, two of the five pseudomonas infections failed to respond, whereas the organisms causing the infection were sensitive to ticarcillin in vitro. during the remaining 67 infecti ...	1973	4791303
clinical studies of cefazolin and comparison with other cephalosporins.	cefazolin, a new cephalosporin derivative, was studied in the treatment of 105 hospitalized patients with a variety of infections including endocarditis, pneumonia, and urinary and soft tissue infections, and was found to be effective in 104 patients. cefazolin was also tested in vitro and shown to be effective against staphylococci, pneumococci, escherichia coli, klebsiella sp., and proteus mirabilis by agar dilution method. it was shown to produce high serum levels when administered in a 250- ...	1973	4791486
[acute senile delirium].		1973	4794194
bacterial colonization of wounds and sepsis in total hip arthroplasty.		1973	4796592
effect of a controlled environment upon the intestinal microflora.		1973	4803209
the role of extracellular slime secretion in the swarming of proteus.		1973	4803945
[sensitivity to antibiotics of proteus and pseudomonas strains of human origin cultured in 2 different media (nutrient agar and dst)].		1973	4806392
an experimental ureteroileal anastomosis to prevent reflux.		1974	4809520
peritalar dislocation.		1974	4809548
aminoglycoside resistance in bacteria medicated by gentamicin acetyltransferase ii, an enzyme modifying the 2'-amino group of aminoglycoside antibiotics.		1974	4810068
postmastectomy lymphangiosarcoma-temporary response to cyclophosphamide chemotherapy in 2 cases.		1974	4811506
comparison of the r-b system and the enterotube for the identification of enterobacteriaceae.		1974	4811739
letter: comparative activity of minocycline and tetracycline.		1974	4812412
iatrogenic matrix calculi.		1974	4813567
single-step purification of urease by affinity chromatography.		1974	4828872
distribution of the isopropylmalate pathway to leucine among diverse bacteria.	alpha-isopropylmalate synthase and beta-isopropylmalate dehydrogenase activities were detected in extracts of the following organisms: chromatium d, rhodopseudomonas spheroides, hydrogenomonas h16, pseudomonas aeruginosa, pseudomonas fluorescens, vibrio extorquens, rhizobium japonicum, alcaligenes viscolactis, escherichia coli b, proteus vulgaris, aerobacter aerogenes, salmonella typhimurium, micrococcus sp., micrococcus lysodeikticus, bacillus polymyxa, bacillus subtilis, and nocardia opaca. th ...	1974	4829932
[comparison of the pathogenic properties of proteus and the results of its serological typing].		1974	4830047
a relationship between nuclear dna and rna synthetic activities and the changes produced by n-methyl-n-nitroso urethane: a study using amoeba proteus as a single cell model.		1974	4830507
endoscopy of ileal conduit with ureteral instrumentation.		1974	4830632
timely topics in microbiology, 1972: enteric gram negative rods.		1974	4831617
[antibacterial activity of tobramycin on providencia].		1974	4837115
urinary calcium and kidney stones in paraplegia. report of an attempted prospective study.		1974	4837663
the contractile vacuole in amoeba proteus: temperature effects.		1974	4838480
[comparative characteristics of proteus hauseri strains of different origins].		1974	4840335
potentiation of the antibacterial effect of methenamine by acetohydroxamic acid.	in vitro testing shows nearly all strains of proteus to be susceptible to methenamine. however, infection by urease-producing bacteria alkalinizes the urine in vivo and prevents generation of formaldehyde, the active metabolite, from methenamine. we have previously shown acetohydroxamic acid (aha) to be an effective inhibitor of bacterial urease in vitro and in vivo. we now present data obtained by use of static and dynamic in vitro systems, which show that, by preventing urease-induced alkalini ...	1974	4840424
interaction between acetohydroxamic acid and 12 antibiotics against 14 gram-negative pathogenic bacteria.	acetohydroxamic acid (aha) is a potent inhibitor of urease which prevents alkalinization of urine and stone formation in rats in the presence of infection caused by urease-producing bacteria. because an antibacterial effect of aha, and synergy between kanamycin and aha have also been described, we studied the interaction between aha and 12 antibiotics against 14 gram-negative bacteria. synergy, sometimes to a striking degree, was found in 17% of interactions; however, antagonism was detected in ...	1974	4840425
cefoxitin, a semisynthetic cephamycin antibiotic: susceptibility studies.	cefoxitin, 3-carbamoyloxymethyl-7-alpha-methoxy-7-[2-(2-thienyl)acetamido]-3-cephem-4- carboxylic acid, is a new semisynthetic cephamycin with broad antibacterial activity. it is highly active against gram-negative microorganisms including indole-positive proteus and serratia strains, which are ordinarily reistant to the cephalosporins. cefoxitin is also highly active against many strains of escherichia coli and proteus mirabilis which are resistant to the cephalosporins. furthermore, e. coli an ...	1974	4840447
cefoxitin, a semisynthetic cephamycin antibiotic: in vivo evaluation.	cefoxitin, 3-carbamoyloxymethyl-7-alpha-methoxy-7-[2-(2-thienyl)acetamido]-3-cephem-4- carboxylic acid, a semisynthetic cephamycin antibiotic shown to have broad-spectrum activity in vitro, is active also in vivo against a wide variety of bacteria including penicillin-resistant staphylococci. it is, however, particularly effective against gram-negative organisms including strains of indole-positive proteus against which cephalothin and cephaloridine are ineffective. when cefoxitin is given subcu ...	1974	4840448
an in vivo comparison of cefoxitin, a semi-synthetic cephamycin, with cephalothin.		1974	4843049
ultrastructural localization of surface concanavalin a binding sites in a unicellular organism, amoeba proteus.		1974	4847604
infections following scleral buckling procedures.		1974	4852420
malignant external otitis.		1974	4853078
the problem of catheter encrustation.	catheter encrustation was studied in a group of long-stay hospital patients using both latex and silicone catheters. moisture accounted for 80% by weight of the encrusted material with both catheters. of the dry weight 90% was composed of protein, calcium, phosphorus, magnesium and uric acid. no relationship was found between the amounts of these substances in the urine and in the encrusted material. high levels of calcium, phosphorus and magnesium were found in the encrusted material from patie ...	1974	4855013
serotyping of proteus rettgeri on the basis of o antigens.		1974	4857623
[chemotherapy of urinary tract infection by gram-negative bacilli].		1966	4860163
etiology of bacteremia.	blood-culture results for a 15-year period from a large southern hospital were tabulated and analyzed for alterations in the bacterial species associated with bacteremia. from 15,543 cultures, 2,410 positive cultures (15.6%) were obtained. these results were grouped into 5-year periods, and an alteration in the incidence of the agents was demonstrated. in the past 5 years, gram-negative bacilli have replaced gram-positive cocci as the most common agents of bacteremia, and several species not for ...	1967	4860529
lipid patterns of selected microorganisms as determined by gas-liquid chromatography.	the cellular lipid patterns of seven strains of microorganisms were examined by gas-liquid chromatography in this preliminary study. the chloroform methanol-soluble lipids were extracted by the soxhlet method from dried cultures which had been grown at 25 +/- 2 c for 18 hr with mechanical shaking. the cellular extract was methylated by use of a low temperature sulfuric acid method, and the resulting methyl esters were chromatographed. considerable differences in the lipid patterns among the seve ...	1967	4860530
colonization of the neonate with staphylococci and gram negative bacilli.		1967	4860696
the diagnosis and localization of urinary infection.		1967	4860767
antibacterial activities of combinations of ampicillin and cloxacillin.		1966	4860773
[the effect of chloramphenicol on the alpha-ketoglutarate-dehydrogenase activity of escherichia coli and proteus vulgaris].		1966	4860856
formamide breakdown reaction for the differentiation of enterobacteriaceae.		1967	4860962
doxycycline hydrochloride (vibramycin) in otorhinolaryngological infections.		1967	4861269
hydrolysis of cephalosporins by beta-lactamases from gram-negative bacteria.		1967	4861905
nitrofurantoin: additional studies comparing in vitro drug susceptibility with clinical bacteriological response.		1966	4862163
use of penicillinase-resistant penicillins to increase the susceptibility of gram-negative bacteria to antibiotics.		1967	4862467
urinary tract infection in the elderly woman.		1967	4862492
hemorrhagic cerebral necrosis in neonatal infants with enterobacterial meningitis.		1967	4862503
incidence of urinary infection in the elderly.		1967	4862532
a study of bacteriuria in hospital population.		1967	4862735
[comparison of the disinfecting activity of substances vufb 3555 and vufb 4013 with septonex spofa].		1967	4862867
an assay method for leukocyte pyrogen.	a method for assaying leukocyte pyrogen is described which is shown to remain valid despite the presence of very large amounts of bacterial endotoxin. it uses a combination of two procedures to inactivate endotoxin: incubation in normal rabbit plasma for 24 hr at 37 degrees c, and injection into rabbits rendered refractory to endotoxin. the validity of the assay was confirmed by formal statistical methods. a simplified assay method is also described which lacks full statistical validity, but is ...	1967	4863132
[on the separation of i-131 in bronchotracheal secretions of guinea pigs. 3. analysis of the secretions].		1967	4863603
incidence of endogenous bacterial infection in murine radiation chimeras with secondary disease.		1967	4863790
ribosyl and deoxyribosyl transfer by bacterial enzyme systems.	the enzymatic transfer of ribose and deoxyribose residues in pyrimidine nucleosides to purines was catalyzed by cell-free extracts of various bacteria. almost all the strains belonging to enterobacteriaceae were capable of catalyzing the transfer reactions. the transfer activities were also detected among some bacterial strains of other families: pseudomonadaceae, corynebacteriaceae, micrococcaceae, bacteriaceae, and bacillaceae. the rates of the transfer reactions were greatly enhanced in the p ...	1967	4863982
identification of mycoplasma and other microorganisms by polyacrylamide-gel electrophoresis of cell proteins.	the proteins of mycoplasma cells of various species produce highly reproducible and species-specific electrophoretic patterns in polyacrylamide gels containing 5 m urea and 35% acetic acid. these electrophoretic patterns can be used for the rapid identification and classification of mycoplasma. preliminary results indicate that this method may also be used for the identification and classification of other microorganisms.	1967	4864403
gentamicin in the treatment of severe, hospital-acquired gram-negative infections.		1967	4864706
cephaloridine. studies of therapeutic activity and untoward effects.		1968	4864724
arginine synthesis in proteus mirabilis.		1967	4865139
[diagnosis and check of the course of chronic urinary tract infections].		1966	4865148
[chemotherapy for infectious diseases. progress in the last several years].		1967	4865493
the effect of urine osmolality and ph on the bactericidal activity of plasma.		1967	4865557
influence of gastric ph on gastric and jejunal flora.		1967	4865576
the silastic bladder patch.		1967	4865653
pneumonias caused by gram-negative bacilli.		1968	4865842
direct method for determining the viability of a freshly generated mixed bacterial aerosol.	a direct method was developed to determine the viability of a freshly generated mixed bacterial aerosol. a mixed suspension of (32)p-labeled staphylococcus aureus and (35)s-labeled proteus mirabilis was nebulized, and the aerosol was collected and separated according to particle size with an andersen sampler. quantitative and qualitative bacteriological and radioisotopic techniques were used to obtain ratios of bacterial to radioactive counts for each organism in samples of the nebulizer suspens ...	1968	4865908
[on the sensitivity of clinically isolated bacterial strains to aminobenzyl and methylphenylisoxazolyl penicillins, with special reference to urinary tract and bile infections].		1967	4866094
[lactic dehydrogenase in urine].		1967	4866518
size changes in isolated nuclei of amoeba proteus on treatment with polyionic substances.		1968	4866533
[clinical and laboratory observations on the treatment of urinary infections with gentamicin].		1967	4866800
[experiments with a new antibiotic in urology].		1967	4866801
a modified electrolyte deficient culture medium.		1968	4867139
[on the use of test strips in salmonella diagnosis].		1966	4867189
[uroprotein coagula in children].		1968	4867643
chromosome transfer between escherichia coli hfr strains and proteus mirabilis.		1967	4867660
effects of a behavioral stimulus on blood pressure of rats with experimental pyelonephritis.		1967	4867676
agar medium for the selective enumeration of coagulase-positive staphylococcus from the rat alimentary tract.	a selective agar medium (medium j(1)) is proposed for the quantitative enumeration of egg yolk-positive (eyp) and egg yolk-negative (eyn) staphylococcus pyogenes from the digestive tract and feces of the rat. this medium, buffered at ph 5.0, is composed of acid casein hydrolysate and yeast extract with 7.5% sodium chloride, 1.6% sodium pyruvate, 0.0008% 2,3,5-triphenyltetrazolium chloride (ttc), and 6% egg yolk emulsion. inoculation is by the pour-plate method and incubation is at 38 c in a wate ...	1968	4867739
identification of d-mannosamine and quinovosamine in salmonella and related bacteria.	lipopolysaccharides of several strains of salmonella, arizona, and proteus vulgaris, have been found to contain two unusual amino sugars not previously reported. these amino sugars were identified as d-mannosamine and quinovosamine (2-amino-2,6-dideoxy glucose).	1968	4867742
congenital neutropenia. report of a fatal case in a negro infant with leukocyte function studies.		1968	4867839
[differences in sensitivity to antibiotics in gram-negative bacteria in different clinical departments].		1966	4868078
antibacterial mechanisms in the urinary bladder.		1967	4868226
the regulation of the synthesis of beta-galactosidase in proteus mirabilis f-lac.		1968	4868246
catabolite repression of the synthesis of beta-galactosidase in proteus mirabilis f-lac.		1968	4868247
purification and comparison of the beta-galactosidase synthesized by escherichia coli f-lac and proteus mirabilis f-lac.		1968	4868248
antiseptic skin care of newborn infants with hexachlorophane.		1968	4868313
bacterial infections in lice injected by weigl method.		1967	4868520
comparative studies of ampicillin, cephalothin and a new cephalosporin derivative, cephaloglycin.		1968	4868527
postmortem bacteriology: a practical method for routine use.		1968	4868789
[antibacterial activity in vitro of cephaloridine].		1968	4868829
distribution of heat-labile and heat-stable inorganic pyrophosphatases among some bacteria.		1967	4868878
a new plating medium for the isolation of enteric pathogens. i. hektoen enteric agar.	a new agar plating medium for the isolation of enteric pathogens is described. this medium contains greater quantities of peptone to offset the inhibitory effects of bile salts. additional carbohydrates and larger quantities of those previously used have also been incorporated into the medium to differentiate pathogens from some of the slow lactose fermenters. the use of an indicator system never used before in a differential plating medium opens new possibilities for improvement over traditiona ...	1968	4869617
[inhibition of proteus swarming by anion-active surface-wetting agents within the framework of the diagnosis of salmonella-shigella and coli-enteritis].		1967	4869956