Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| thermodynamics of cooperative dna recognition at a replication origin and transcription regulatory site. | binding cooperativity guides the formation of protein-nucleic acid complexes, in particular those that are highly regulated such as replication origins and transcription sites. using the dna binding domain of the origin binding and transcriptional regulator protein e2 from human papillomavirus type 16 as model, and through isothermal titration calorimetry analysis, we determined a positive, entropy-driven cooperativity upon binding of the protein to its cognate tandem double e2 site. this cooper ... | 2010 | 21047141 |
| quality of life of homosexual males with genital warts: a qualitative study. | abstract: | 2010 | 21050431 |
| [effect of adenovirus delivered tissue inhibitor of metalloproteinases 3 on the irradiation sensitivity of human papillomavirus positive cervical cancer cells]. | to explore the effects of adenovirus-delivered tissue inhibitor of metalloprotein- ases-3 (ad-timp-3) on the irradiation sensitivity of human papillomavirus (hpv)-positive cervical cancer cells. | 2010 | 21050555 |
| seroprevalence of human papillomavirus 6, 11, 16, and 18 in young primiparous women in sao paulo, brazil. | data on epidemiology of hpv infection are needed for the development of human papillomavirus (hpv) vaccine recommendations, especially in countries where hpv vaccination is not yet included in public vaccination programs. the aim of this study was to determine the prevalence of serum antibodies to hpv types 6, 11, 16, and 18 and associated factors among young women after birth of the first child. | 2010 | 21051985 |
| human papillomavirus and epstein barr virus in oral hairy leukoplakia among hiv positive venezuelan patients. | oral hairy leukoplakia (ohl) is commonly found in individuals infected with hiv and represents the most frequent oral manifestation. the purpose of this study was to detect the presence of human papillomavirus (hpv) and epstein barr virus (ebv) in ohl of hiv+ venezuelan patients. we evaluated 21 hiv+ adult patients with clinically present ohl lesions: 11 under antiretroviral therapy, 10 without therapy, and 10 oral mucosal samples as controls. nested-pcr was used to detect ebv and hpv infection. ... | 2010 | 21053684 |
| feasibility of using maternal cancer screening visits to identify adolescent girls eligible for human papillomavirus vaccination. | breast or cervical cancer screening visits may present an opportunity to motivate mothers to have their daughters vaccinated against human papillomavirus (hpv). in preparation for a future intervention study, we sought to establish the feasibility of using these visits to identify women with at least one daughter in the appropriate age range for adolescent hpv vaccination. | 2010 | 21054184 |
| detection of human papilloma virus in normal skin and in superficial and nodular basal cell carcinomas in immunocompetent subjects. | background human papilloma virus (hpv) is increasingly recognized as an important human carcinogen but its role in the aetiopathogenesis of basal cell carcinoma (bcc) in immunocompetent individuals is unclear. objective a prospective case-control study was designed to compare the prevalence of hpv in bcc and normal skin samples from immunocompetent subjects and to assess the influence of different clinical features on the risk of cutaneous hpv. methods a total of 142 samples from 70 bcc cases ... | 2010 | 21054564 |
| advancements in the control of genital human papillomavirus infections and related diseases: highlighting australia's role. | 2010 | 21058495 | |
| commentary on opinion pieces re australian human papillomavirus vaccine policy. | 2010 | 21058498 | |
| development of peptide aptamer microarrays for detection of hpv16 oncoproteins in cell extracts. | protein microarrays represent an emerging technology that promises to facilitate high-throughput proteomics. the major goal of this technology is to employ peptides, full-length proteins, antibodies, and small molecules to simultaneously screen thousands of targets for potential protein-protein interactions or modifications of the proteome. this article describes the performance of a set of peptide aptamers specific for the human papillomavirus (hpv) type 16 oncoproteins e6 and e7 in a microarra ... | 2010 | 21059336 |
| the association between dietary intake and cervical intraepithelial neoplasia grade 2 or higher among women in a high-risk rural area of china. | objective: to evaluate the relationship between dietary intake and risk of cervical intraepithelial neoplasia grade 2 or higher (cin2+) while controlling for human papillomavirus (hpv) infection. methods: in 1999 and 2002, 11,031 women aged 35-50, were screened as part of two cross-sectional population-based cervical cancer screening studies in china. dietary food intake information was collected by a 79-item food frequency questionnaire (ffq). 748 hpv-positive women (557 normal biopsy; 95 cin2, ... | 2010 | 21061128 |
| curcumin suppresses human papillomavirus oncoproteins, restores p53, rb, and ptpn13 proteins and inhibits benzo[a]pyrene-induced upregulation of hpv e7. | curcumin has great potential as a chemopreventive and chemotherapeutic agent; however, its effects on human papillomavirus (hpv)-associated molecular events are inadequately explored. this study examined the effects of curcumin on hpv-associated pathways involved in developing cervical cancer. we demonstrate for the first time that curcumin treatment suppresses cervical cancer cell growth in a three-dimensional raft culture system. curcumin also inhibits tumorigenic characteristics as shown by d ... | 2011 | 21061268 |
| expression of cytokines in cervical stroma in patients with high-grade cervical intraepithelial neoplasia after treatment with intralesional interferon alpha-2b. | conservative treatment with interferons (ifns) has the advantage of preserving reproductive capacity in patients with grade 2 or 3 cervical intraepithelial neoplasia (cin). the objective of this work was to study patients with high-grade cin treated with intralesional ifn alpha-2b and to analyze the expression of th1, th2 and th3 cytokines in cervical stroma. we observed that patients with a satisfactory response (60%) to treatment with ifn alpha-2b expressed more th1 (ifn-gamma tnf-alpha, il-2) ... | 2010 | 21061793 |
| the clinical significance of hpv screening in premalignant cervical lesions. | we evaluated the clinical significance of human papilloma virus (hpv) screening in premalignant cervical lesions. | 2010 | 21061813 |
| hpv vaccine acceptance among female greek students. | the human papillomavirus (hpv) vaccine protects against hpv-related disease. the aim of this study was to assess acceptance of hpv vaccination among female greek students. a sample of 573 students aged 18-25 years participated in the present study. interviews were performed using a structured questionnaire. of the respondents, 3% were not aware of the hpv vaccine. of the subjects, 10.47% had been administered the hpv vaccine. of the respondents who had not been administered the vaccine, 43.86% w ... | 2010 | 21061928 |
| integrative genomic approaches in cervical cancer: implications for molecular pathogenesis. | cervical cancer (cc) as a single diagnostic entity exhibits differences in clinical behavior and poor outcomes in response to therapy in advanced tumors. although infection of high-risk human papillomavirus is recognized as an important initiating event in cervical tumorigenesis, stratification of cc into subclasses for progression and response to treatment remains elusive. existing knowledge of genetic, epigenetic and transcriptional alterations is inadequate in addressing the issues of diagnos ... | 2010 | 21062161 |
| cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. | baseline information on human papillomavirus (hpv) prevalence and type distribution is highly desirable to evaluate the impact of prophylactic hpv vaccines in the near future. | 2010 | 21067372 |
| quadrivalent human papillomavirus vaccination and trends in genital warts in australia: analysis of national sentinel surveillance data. | quadrivalent human papillomavirus (hpv) vaccine has high efficacy in clinical trials but no reports describe its effects at a population level. from july, 2007, australia was the first country to fund a vaccination programme for all women aged 12-26 years. we established a national surveillance network in australia and aimed to identify trends in diagnoses of genital warts in 2004-09. | 2010 | 21067976 |
| human papillomavirus (hpv) types 16, 18, 31, 45 dna loads and hpv-16 integration in persistent and transient infections in young women. | hpv burden is a predictor for high-grade cervical intraepithelial neoplasia and cancer. the natural history of hpv load in young women being recently exposed to hpv is described in this paper. | 2010 | 21070660 |
| systemic lupus erythematosus, human papillomavirus infection, cervical pre-malignant and malignant lesions: a systematic review. | the purpose of this study was to review and evaluate systematically the scientific evidence on the relationship between systemic lupus erythematosus (sle), human papillomavirus (hpv) infection, pre-cancerous cervical abnormalities, and cervical cancer. establishing strict inclusion and exclusion criteria, we performed an extensive search for studies in medline and bireme databases to assess the studies that evaluated the frequency of hpv infection, pre-cancerous cervical abnormalities, and cervi ... | 2010 | 21072553 |
| genomic instability and cancer: lessons learned from human papillomaviruses. | high-risk hpv e6 and e7 oncoproteins cooperate to subvert critical host cell cycle checkpoint control mechanisms in order to promote viral genome replication. this results not only in aberrant proliferation but also in host cellular changes that can promote genomic instability. the hpv-16 e7 oncoprotein was found to induce centrosome abnormalities thereby disrupting mitotic fidelity and increasing the risk for chromosome missegregation and aneuploidy. in addition, expression of the high-risk hpv ... | 2010 | 21075512 |
| human papillomavirus (hpv)-type distribution in relation to oral contraceptive use in women with cervical intraepithelial neoplasia, durban, south africa. | to determine hpv-type distribution among women with cervical dysplasia in relation to oral contraceptive usage. | 2010 | 21077468 |
| differential expression of cellular micrornas in hpv-11 transfected cells. an analysis by three different array platforms and qrt-pcr. | human papillomavirus type 11 (hpv-11) infects the genital and the respiratory tract leading to condylomas and respiratory papillomatosis. hpv infections are restricted to epithelial tissue and the progression through the virus lifecycle is tightly coordinated to the differentiation of the host cell. the changes of cellular micrornas by hpv-11 gene expression were investigated in a cell culture model of hacat cells transfected with hpv-11, with the goal of understanding which cellular processes w ... | 2010 | 21078297 |
| human papillomavirus: the silent intruder. | 2010 | 21079318 | |
| author's reply to: multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants. | 2010 | 21080437 | |
| civil society: a critical new advocate for vaccination in europe. | the vaccinology landscape has changed, with national authorities now being increasingly accountable to new stakeholders such as health insurers, regional regulatory bodies, the media, and civil society. here, we discuss how civil society organisations (csos), such as patient and women's groups, have become important drivers in the introduction and sustainability of new vaccination programs. this shift in public implication in vaccine policy has been well illustrated in the recent introduction of ... | 2010 | 21081178 |
| cost-effectiveness of screening high-risk hiv-positive men who have sex with men (msm) and hiv-positive women for anal cancer. | anal cancer is uncommon and predominantly a disease of the elderly. the human papillomavirus (hpv) has been implicated as a causal agent, and hpv infection is usually transmitted sexually. individuals who are human immunodeficiency virus (hiv)-positive are particularly vulnerable to hpv infections, and increasing numbers from this population present with anal cancer. | 2010 | 21083999 |
| prospective evaluation of longitudinal changes in human papillomavirus genotype and phylogenetic clade associated with cervical disease progression. | changes in the hpv genotype detected in patients over time could alter cervical disease progression. identification of patterns in the alteration of hpv genotype should also be related to cytological and histological findings. thus, we assessed the risk for low-grade squamous intraepithelial lesion (lsil) or high-grade sil (hsil)/squamous cell carcinoma (scc) associated with alterations in the hpv genotype detected, presence of multiple hpv genotypes, and individual genotyping or hpv clade group ... | 2010 | 21087788 |
| assessment of immunohistochemistry for p16ink4 and high-risk hpv dna by in situ hybridization in esophageal squamous cell carcinoma. | the role of high-risk human papillomavirus (hpv) in the pathogenesis of esophageal squamous cell carcinoma (escc) remains unclear. p16(ink4) is used as a surrogate marker to detect hpv-related tumors but has had discrepant results in escc. in this study, 32 cases of escc were examined to determine the relationship between p16(ink4) expression and high-risk hpv. all the tumors were stained by immunohistochemistry for p16(ink4). tumors having p16(ink4) nuclear and/or nuclear and cytoplasmic expres ... | 2010 | 21087981 |
| maternal support for human papillomavirus vaccination in honduras. | cervical cancer is a leading cause of cancer death for women in latin america, and vaccinating against human papillomavirus (hpv) has the potential to limit this disease. we sought to determine honduran women's awareness of hpv vaccination and interest in vaccinating their daughters against hpv. | 2010 | 21091226 |
| condyloma accuminata: what's in a name? | 2010 | 21093667 | |
| factors associated with initiation and completion of human papillomavirus vaccine series among young women enrolled in medicaid. | to determine age- and race-specific uptake rates of human papillomavirus (hpv) vaccine among females aged 9-20 years who participated in the florida medicaid during the first 2 years after approval by the food and drug administration, and to identify factors associated with hpv vaccine initiation and series completion. | 2010 | 21094437 |
| chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohort. | cofactors might affect the risk of the rare progression from infection with carcinogenic human papillomavirus (hpv) to cervical premalignancy to invasive cancer. some studies have observed that chlamydia trachomatis infection is associated with increased risk for cervical cancer. in a large prospective cohort, we assessed the role of c trachomatis in cervical premalignancy and addressed confounding by hpv. | 2010 | 21098758 |
| colposcopy prediction of progression in human papillomavirus infections with minor cervical lesions. | to evaluate the risk of progression to cervical intraepithelial neoplasia (cin) grade 2 or 3 in women with positive human papillomavirus (hpv) testing and low-grade (low-grade squamous intraepithelial lesions), borderline (atypical squamous cells of undetermined significance), or no cervical lesions, and to determine the accuracy of initial colposcopy to predict progression. | 2010 | 21099598 |
| common abnormal results of pap and human papillomavirus cotesting: what physicians are recommending for management. | to evaluate the association between physician and practice characteristics and adherence to management guidelines to better understand the factors associated with different screening recommendations by primary care physicians. | 2010 | 21099599 |
| projecting the need for gynecologic oncologists for the next 40 years. | to estimate the ratio of gynecologic cancer cases to practicing gynecologic oncologists in the united states over the next 40 years. | 2010 | 21099604 |
| rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young women. | to describe the natural history of cervical intraepithelial neoplasia (cin) 2 in a prospective study of adolescents and young women, and to examine the behavioral and biologic factors associated with regression and progression. | 2010 | 21099605 |
| inhibition of cervical cancer cell growth in vitro and in vivo with dual shrnas. | rna interference (rnai)-based gene silencing is widely used in laboratories for gene function studies and also holds a great promise for developing treatments for diseases. however, in vivo delivery of rnai therapy remains a key issue. lentiviral vectors have been employed for stable gene transfer and gene therapy and therefore are expected to deliver a stable and durable rnai therapy. but this does not seem to be true in some disease models. here, we showed that lentivirus delivered short-hairp ... | 2010 | 21102424 |
| human papillomavirus genotype distribution in cervical samples collected in routine clinical practice at the nantes university hospital, france. | objective: the objective was to assess the human papillomavirus (hpv) overall and type-specific prevalence in smears collected during routine clinical practice. design: hpv genotyping and smears were performed independently between 2000 and 2006 for routine clinical follow-up (primary screening and follow-up) in the university hospital of nantes, france. population: all women with a cytological sample collected no more than 12 months before hpv genotyping were included. methods: pcr was performe ... | 2010 | 21107591 |
| low prevalence of hpv in brazilian children with retinoblastoma. | retinoblastoma is the most frequent intra-ocular malignant tumor of the childhood, occurring in 1 of 18,000-30,000 live births. little is known about the causes of sporadic retinoblastoma and only a few authors have investigated the etiologic role of human papillomavirus (hpv), with controversial results. formalin-fixed, paraffin-embedded tissue blocks containing retinoblastoma were retrieved from the archives of the department of pathology at hospital a c camargo, são paulo, brazil. all patient ... | 2011 | 21108347 |
| comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study. | human papillomavirus (hpv) infection is a major risk factor for the development of nearly all cases of cervical cancer worldwide. the presence of hpv dna in cases of esophageal squamous-cell carcinoma (escc) has been reported repeatedly from shantou, china, and other regions with a high incidence of esophageal carcinoma (ec). however, unlike in cervical squamous-cell carcinoma (cscc), in escc, the characteristics of hpv are unclear. thus, the role of high-risk hpv types in the carcinogenesis of ... | 2010 | 21108842 |
| human papillomavirus vaccine coverage in the united states, national health and nutrition examination survey, 2007-2008. | this study aims to estimate human papillomavirus (hpv) vaccine coverage by demographic and sexual behavior characteristics 1-2 years after vaccine licensure in a nationally representative sample of females aged 9-59 years in the united states. | 2010 | 21108962 |
| nk1.1+ cells are important for the development of protective immunity against mhc i-deficient, hpv16-associated tumours. | loss or downregulation of mhc class i molecules on tumour cells is a common mechanism by which tumours can escape t-cell mediated immune responses. in this study, we examined the role of different immune cell lineages in the development of immunity against tumours of the same aetiology but with different mhc class i expression. in vivo depletion of cd8+ cells, but not of cd4+ or nk1.1+ cells in the immunization period resulted in complete elimination of the protective effects of immunization wit ... | 2011 | 21109988 |
| a generally applicable cost-effectiveness model for the evaluation of vaccines against cervical cancer. | this study aimed at evaluating the cost-effectiveness of human papillomavirus virus (hpv) vaccination in france, using a generally applicable succinct cohort model. | 2010 | 21110060 |
| [ttv and hpv co-infection in cervical smears of patients with cervical lesions in littoral of zhejiang province]. | to investigate the prevalence of transfusion-transmitted virus (ttv) and human papillomavirus (hpv) co-infection in cervical smears of patients with cervical lesions in littoral of zhejiang province and analysis of transmitted route. | 2010 | 21110428 |
| evaluation of two commercialised in situ hybridisation assays for detecting hpv-dna in formalin-fixed, paraffin-embedded tissue. | introduction: the role of human papilloma virus (hpv) in the pathogenesis of anogenital dysplasia is now conclusive. however, hpv detection in formalin-fixed and paraffin-embedded tissues remains controversial. therefore, the aim of this study was to evaluate morphological changes directly in tissue specimens using a hpv-dna detection system involving hpv in situ hybridisation. materials and methods: samples from patients with cervical carcinoma were analysed using the genpoint hpv dna probe coc ... | 2010 | 21113720 |
| optimising human papillomavirus self-testing for high risk women. | human papillomavirus self-tests that can be used at home and returned by mail may increase cervical cancer screening rates. growing evidence suggests that self-test methods could increase screening for high-risk and hard-to-reach populations. the purpose of this study was to identify which self-test device women prefer and why. | 2010 | 21115503 |
| re: longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection. | 2010 | 21115883 | |
| [genotyping of oncogenic human papilloma viruses in women with hg sil diagnosis]. | development of primary prevention of cervical cancer in other words a vaccination against selected, oncogenic hpv types, entails an increasing importance of epidemiological studies and prevalence of various types of human papilloma virus. the incidence of hpv varies depending on the geographic location of the population. the effectiveness of primary prevention against hpv 16, 18, in the context of reducing the incidence of cervical cancer will depend, among others, on the prevalence of these typ ... | 2010 | 21117301 |
| immunisation of adolescents in the uk. | the recent introduction of routine immunisation against human papillomavirus (hpv) in adolescent girls in the uk has focused attention on the potential for immunisation in this age group. in this review the authors suggest that this is an opportunity that is not being fully utilised. in particular, there are arguments for adolescent vaccines to boost immunity against bordetella pertussis and neisseria meningitidis infections, and the successful implementation of the hpv vaccine could be taken as ... | 2010 | 21119024 |
| small lymphocytic lymphoma obscuring microscopic tonsillar squamous cell carcinoma: an unknown occurrence with a known primary. | head and neck squamous cell carcinoma (hnscc) often presents with cervical lymph node metastases and at times the primary tumor cannot be identified despite extensive workup. lymphoma is the second most common neoplasm in the head and neck region but is seldom synchronous with hnscc and rarely involves regional mucosal sites. we report herein a rare occurrence of tonsillar involvement by small lymphocytic lymphoma (sll) incidentally detected during the workup for a cervical lymph node scc metast ... | 2010 | 21120710 |
| role of human papillomavirus vaccine in prevention of cervical cancer. | 2010 | 21121382 | |
| human papillomavirus: clinical manifestations and prevention. | human papillomaviruses cause the most common sexually transmitted infection in the world and are responsible for nearly all cases of cervical cancer. genital human papillomavirus infection can be divided into low-risk infections (causing genital warts) and high-risk infections (causing cervical intraepithelial neoplasia, and cervical and other cancers). exposure to human papilloma- virus typically produces a sexually transmitted infection that may progress to a clinically apparent process, such ... | 2010 | 21121531 |
| up-regulation of p18ink4c expression by oncogenic hpv e6 via p53-mir-34a pathway. | binding of p53 to mir-34a promoter activates the expression of tumor suppressive mir-34a. oncogenic hpv infection downregulates mir-34a expression through viral e6 degradation of p53. in this report, we found that mir-34a specifically targets p18ink4c, a cdk4 and cdk6 inhibitor induced by e2f transactivation. hpv18(+) hela cells with ectopic mir-34a expression or by e6 sirna knockdown-induced expression of endogenous mir-34a exhibited a substantial reduction of p18ink4c in a dose-dependent manne ... | 2010 | 21128241 |
| protein flexibility directs dna recognition by the papillomavirus e2 proteins. | although dna flexibility is known to play an important role in dna-protein interactions, the importance of protein flexibility is less well understood. here, we show that protein dynamics are important in dna recognition using the well-characterized human papillomavirus (hpv) type 6 e2 protein as a model system. we have compared the dna binding properties of the hpv 6 e2 dna binding domain (dbd) and a mutant lacking two c-terminal leucine residues that form part of the hydrophobic core of the pr ... | 2010 | 21131281 |
| [survey among female university students on hpv infection epidemiology and prevention]. | human papilloma virus (hpv) is one of the most common sexually transmitted infections. the vaccine has the maximum benefit when given before starting sexual activity and its efficacy is proved also in sexually active women in which the incidence of the infection is higher. in 2010 a questionnaire on hpv was administered to 299 female students of university of rome tor vergata. the results compared with those obtained in a similar 2007-08 survey, and with international data, showed that knowledge ... | 2010 | 21132046 |
| knowledge and risk perception regarding hpv among latino alternative school students in houston, texas. | human papillomavirus (hpv) is the most common sti among youth in the u.s. as alternative school students are at higher risk of acquiring stis compared to regular high school students, this study examined hpv knowledge and risk perception among latino youth attending 9 alternative high schools in houston, texas. hpv knowledge measures assessed prevalence, health consequences, symptoms, transmission, and risk reduction strategies. three measures assessed perceived risk. the sample included 414 you ... | 2009 | 21132052 |
| comparison of self-collected and clinician-collected materials for cervical cytology and human papillomavirus genotyping: analysis by linear array assay. | this study compared the usefulness of self-collected (sc) and clinician-collected (cc) materials for cervical cytology and human papillomavirus (hpv) genotyping. | 2010 | 21135530 |
| the hpv16 e6 binding protein tip-1 interacts with arhgef16, which activates cdc42. | guanidine exchange factor (gef)-catalysed activation of rho proteins such as cdc42 has been shown to have a crucial role in cellular transformation, malignant progression and invasion. we have previously shown that the hpv16 e6 oncoprotein binds to the pdz domain protein tax-interacting-protein 1 (tip-1) and we now report identification and functional analysis of a novel tip-1 binding gef. | 2010 | 21139582 |
| integrating novel primary- and secondary-prevention strategies: the next challenge for cervical cancer control. | the advent of prophylactic vaccines against human papillomavirus (hpv) infection, the cause of cervical cancer, and of new molecular methods to screen for this disease have become key developments in cancer control in the last 5 years. although pap cytology has had a significant history as a key method for cervical cancer screening, not all countries have benefited from this technology or have been able to implement the necessary public health steps to manage and treat the precancerous lesions t ... | 2010 | 21142659 |
| vaccination against human papillomavirus types 16 and 18: the impact on cervical cancer. | 2010 | 21142854 | |
| introduction of hematoxylin as an electroactive label for dna biosensors and its employment in detection of target dna sequence and single-base mismatch in human papilloma virus corresponding to oligonucleotide. | for the detection of dna hybridization, a new electrochemical biosensor was developed on the basis of the interaction of hematoxylin with 20-mer deoxyoligonucleotides (from human papilloma virus, hpv). the study was performed based on the interaction of hematoxylin with an alkanethiol dna probe self-assembled gold electrode (ss-dna/aue) and its hybridization form (ds-dna/aue). the optimum conditions were found for the immobilization of hpv probe on the gold electrode (aue) surface and its hybrid ... | 2010 | 21146975 |
| aptima hpv e6/e7 mrna test is as sensitive as hybrid capture 2 assay but more specific at detecting cervical precancer and cancer. | detection of human papillomavirus (hpv) e6/e7 oncogene expression may be more predictive of cervical cancer risk than testing for hpv dna. the aptima hpv test (gen-probe) detects e6/e7 mrna of 14 oncogenic types. its clinical performance was compared with that of the hybrid capture 2 dna test (hc2; qiagen) in women referred for colposcopy and those routinely screened. aptima was also compared with the pretect hpv-proofer e6/e7 mrna assay (proofer; norchip) in the referral population. cervical sp ... | 2010 | 21147950 |
| human papillomavirus e7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases. | infection by human papillomaviruses (hpv) leads to the formation of benign lesions, warts, and in some cases, cervical cancer. the formation of these lesions is dependent upon increased expression of proangiogenic factors. angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-inducible factor 1α (hif-1α). our studies indicate that the hpv e7 protein enhances hif-1 transcriptional activity whereas e6 functions to counteract the repressive effects of p53. bo ... | 2010 | 21148070 |
| prevalence and determinants of high-risk human papillomavirus infection in women from a sub-saharan african community. | background:: human papillomavirus infection with high-risk types (hr-hpv) is a necessary cause of cervical cancer, the most common malignancy among sub-saharan african women. little is known about prevalence of cervical hr-hpv infection in this region. methods:: a cross-sectional study of 1528 women examined the determinants of hr-hpv infection among women in kinshasa, democratic republic of congo. information was collected on sociodemographic, reproductive, lifestyle characteristics, and health ... | 2010 | 21150817 |
| computer-aided analysis of structural properties and epitopes of iranian hpv-16 e7 oncoprotein. | infection by human papillomavirus type 16 (hpv-16) is the cause of 50% or more of cervical cancers in women. the e7 oncoprotein of hpv-16 has long been known as a potent immortalizing and transforming agent. we used different servers like pseaac, mhc_binding, mhc_ii_binding and expasy for the present computational prediction. the results for t cell epitopes showed that b1501, a0203, a0201, a0202, a6801 and drb0405 alleles had lower ic50 than other alleles. we also predicted several peptides with ... | 2010 | 21153780 |
| human papillomavirus vaccine: now for boys too? | 2011 | 21157346 | |
| the molecular biology of head and neck cancer. | head and neck squamous cell carcinomas (hnsccs) are caused by tobacco and alcohol consumption and by infection with high-risk types of human papillomavirus (hpv). tumours often develop within preneoplastic fields of genetically altered cells. the persistence of these fields after treatment presents a major challenge, because it might lead to local recurrences and second primary tumours that are responsible for a large proportion of deaths. aberrant signalling pathways have been identified in hns ... | 2010 | 21160525 |
| increased plasma levels of adipokines and inflammatory markers in older women with persistent hpv infection. | we observed diminished lymphoproliferation to multiple stimuli in older women with persistent cervical human papillomavirus (hpv) infection. adipokines are a class of inflammatory cytokines that are altered in some persistent infections. the objective was to compare the level of adipokines and inflammatory cytokines in heparinized plasma from women with persistent hpv cervical infection (cases, n=50, oversampled for their weak lymphoproliferation responses) with women with no evidence of persist ... | 2010 | 21167737 |
| vaccine generated immunity targets an hpv16 e7 hla-a2.1-restricted cd8(+) t cell epitope relocated to an early gene or a late gene of the cottontail rabbit papillomavirus (crpv) genome in hla-a2.1 transgenic rabbits. | the newly established hla-a2.1 transgenic rabbit model has proven useful for testing the immunogenicity of well known and computer-predicted a2-restricted epitopes. in the current study we compared the protective immunity induced to a preferred hpv16 e7 a2-restricted epitope that has been relocated to positions within the crpv e7 gene and the crpv l2 gene. epitope expression from both the e7 protein and the l2 protein resulted in increased protection against viral dna challenge of the hla-a2.1 t ... | 2010 | 21167863 |
| human papillomavirus is detectable in barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance. | barrett's esophagus (be), a known precursor of esophageal adenocarcinoma has recently been associated with human papillomavirus (hpv). p16(ink4a) expression is a recognized surrogate marker of hpv infection in the cervix. | 2010 | 21169053 |
| procedural and temporal compliance to cervical cancer screening guidelines in a cdc-funded program in alaska. | to estimate changes in clinical practice in a cervical cancer screening program after the american society for colposcopy and cervical pathology's issuance of 2006 consensus guidelines (2006cg) for managing abnormal pap tests. | 2011 | 21169865 |
| association of human papillomavirus-related knowledge, attitudes, and beliefs with hiv status: a national study of gay men. | anal cancer and other diseases caused by human papillomavirus (hpv) are more common among people who are hiv-positive. to understand the potential role of hiv status in hpv prevention efforts, we examined hpv-related knowledge, attitudes, and beliefs among hiv-positive and hiv-negative gay men. | 2011 | 21169868 |
| [prevalence of human papillomavirus in the pubic hair follicles of healthy men and male patients with genital warts]. | human papillomavirus (hpv) commonly exists in healthy individuals, but its prevalence in the pubic hair follicles is not yet clear, nor is the relationship between hpv infection in the pubic hair follicles and the recurrence of genital warts in men. this study aimed to investigate hpv infection in the pubic hair follicles of healthy men and patients with genital warts, and to look into the correlation of hpv infection with recurrent genital warts. | 2010 | 21171259 |
| correlation of cellular immunity with human papillomavirus 16 status and outcome in patients with advanced oropharyngeal cancer. | to determine whether the favorable outcome associated with human papillomavirus (hpv) 16-positive oropharyngeal cancer is related to a patient's adaptive immunity. | 2010 | 21173378 |
| maldi imaging as a specific diagnostic tool for routine cervical cytology specimens. | cervical squamous cell carcinoma (scc) is among the most common malignancies in women worldwide. in developed countries routine cytology screening has dramatically reduced scc mortality within the last three decades. high risk (hr) human papilloma virus (hpv) infection is the main causal factor in nearly 100% of invasive sccs, in most cases of low grade squamous intraepithelial lesion (lsil) and in nearly all cases of high grade squamous intraepithelial lesion (hsil). detection of hr-hpv dna has ... | 2010 | 21174066 |
| variation of human papillomavirus 16 in cervical and lung cancers in sichuan, china. | although the crucial role of human papillomaviruses (hpvs), especially hpv-16 in various cancers has been confirmed, the variation of hpv-16 among different cancers have not been investigated in a specific geographic location. in order to elucidate whether similar hpv-16 variants are involved in different kinds of cancers in the same geographic location, the analysis of sequence variants of e6 and e7 oncogenes and l1 gene of hpv-16 in cervical and lung cancers in sichuan, china, was carried out. ... | 2010 | 21175246 |
| awareness and knowledge of hpv, cervical cancer, and vaccines in young women after first delivery in são paulo, brazil--a cross-sectional study. | the success of hpv vaccination programs will require awareness regarding hpv associated diseases and the benefits of hpv vaccination for the general population. the aim of this study was to assess the level of awareness and knowledge of human papillomavirus (hpv) infection, cervical cancer prevention, vaccines, and factors associated with hpv awareness among young women after birth of the first child. | 2010 | 21176230 |
| [analysis of high risk factors associated with cervical intraepithelial neoplasia in married women aged 25 - 54 years in beijing between 2007 - 2008]. | to investigate high risk factors associated with cervical intraepithelial neoplasia (cin) in married women aged 25 to 54 years in beijing. | 2010 | 21176557 |
| detection of human papillomavirus in bronchoalveolar lavage samples in immunocompetent children. | human papillomavirus (hpv) has been detected in lungs of adults and has been proposed to play a role in lung carcinogenesis. however, no data are currently available on the incidence of hpv in the lower respiratory tract of children. | 2011 | 21178656 |
| [the treatment research of people with different types of hpv infection in sterile patients]. | explore the optimal treatment of infertility patients infected with different types of human papillomavirus (hpv). | 2010 | 21186535 |
| two distinct pathways to development of squamous cell carcinoma of the vulva. | squamous cell carcinoma (scc) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women. the future numbers of patients with vulvar scc is expected to rise, mainly because of the proportional increase in the average age of the general population. two different pathways for vulvar scc have been put forth. the first pathway is triggered by infection with a high-risk-type human papillomavirus (hpv). integration of the hpv dna into the host geno ... | 2010 | 21188235 |
| long-term persistence of systemic and mucosal immune response to hpv-16/18 as04-adjuvanted vaccine in preteen/adolescent girls and young women. | vaccination against oncogenic human papillomavirus (hpv) types is one key intervention for cervical cancer prevention. this follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the hpv-16/18 as04-adjuvanted vaccine administered to young women aged 10-25 years. serum and cervicovaginal secretion (cvs) samples were collected at pre-specified time-points during the 48-month follow-up period. anti-hpv-16/18 antibody levels in serum ... | 2010 | 21190190 |
| hpv prophylactic vaccination: the first years and what to expect from now. | new prophylactic hpv vaccines have the power to prevent many hpv infections, thus reducing the burden of hpv-associated diseases. two vaccines composed of hpv l1 proteins self assembled into virus-like particles (vlps) have been developed: one containing vlps of hpv types 6, 11, 16 and 18, while the other vaccine is composed of hpv 16 and 18 vlps. large phase ii and iii clinical trials to assess prophylactic efficacy have been conducted in which both hpv infection endpoints and disease endpoints ... | 2010 | 21190794 |
| performance of the aptima high-risk human papillomavirus mrna assay in a referral population in comparison with hybrid capture 2 and cytology. | this study compared the aptima human papillomavirus (hpv) (ahpv; gen-probe incorporated) assay, which detects e6/e7 mrna from 14 high-risk types, the hybrid capture 2 hpv dna (hc2; qiagen incorporated) test, and repeat cytology for their ability to detect high-grade cervical lesions (cervical intraepithelial neoplasia grade 2+ [cin2+]) in women referred to colposcopy due to an abnormal papanicolaou (pap) smear. a total of 424 clinical specimens, stored in liquid-based cytology (lbc) vials at roo ... | 2010 | 21191046 |
| human papillomavirus infection in honduran women with cervical intraepithelial neoplasia or cervical cancer. | the aims of this study were to investigate human papillomavirus (hpv) genotypes in women with cervical intraepithelial lesions and cervical cancer (cc) in honduras and to identify epidemiological cofactors that contribute to the development of cc. | 2011 | 21192177 |
| can self vaginal douching for high risk hpv screening replace or assist efficacy of cervical cancer screening? | to study the accuracy of self vaginal douching and collection for hpv types 16, 18, 31 and 33 in women visiting thammasat hospital for the explicit purpose of cervical screening. | 2010 | 21198300 |
| regulation of immune responses to hpv infection and during hpv-directed immunotherapy. | the recent development of vaccines prophylactic against human papillomavirus (hpv) infection has the potential to reduce the incidence of cervical cancer globally by up to 70% over the next 40 years, if universal immunization is adopted. as these prophylactic vaccines do not alter the natural history of established hpv infection, immunotherapies to treat persistent hpv infection and associated precancers would be of benefit to assist with cervical cancer control. efforts to develop immuno-therap ... | 2011 | 21198666 |
| quadrivalent human papillomavirus (hpv) vaccine: a review of safety, efficacy, and pharmacoeconomics. | what is known and background: the introduction of vaccines has lead to a significant reduction in morbidity and mortality from diseases such as measles, rubella and poliomyelitis, as well as the eradication of smallpox (ertl hc, xiang z (1996) the journal of immunology, 156, 3579-3582). a recent vaccine approved by the food and drug administration (fda) is the recombinant quadrivalent human papillomavirus (hpv) vaccine (merck, gardasil®). concerns raised with this preventive measure include safe ... | 2011 | 21198715 |
| preclinical development of highly effective and safe dna vaccines directed against hpv 16 e6 and e7. | to allow vaccination irrespective of hla type, dna vaccines encoding full-length antigens are required. however, here, we demonstrate that the immunogenicity of dna vaccines encoding the full-length human papillomavirus (hpv) type 16 e7 and e6 proteins is highly reduced compared to vaccines encoding only the immunodominant epitope. furthermore, the low remaining immunogenicity is essentially lost for both e7 and e6 when a nononcogenic "gene-shuffled" variant is utilized. to address these issues, ... | 2011 | 21207427 |
| human papillomavirus in brazilian women with and without cervical lesions. | human papillomavirus (hpv) high-risk (hr) types are the causal factor for cervical cancer and premalignant dysplasia. data on frequency of hpv types provide a basis to design and evaluate hpv prevention programs. taking into account the heterogeneity of hpv types across and within populations this study aims to access the hpv frequency in brazilian women. | 2011 | 21208414 |
| long-term persistence of human papillomavirus in environments. | the possibility of its indirect transmission of human papillomavirus (hpv) via formites has been widely raised but with no biological proof. this study explored the durability of hpv16 pseudoviruses and native viruses in different environmental contamination scenarios. | 2011 | 21208649 |
| the influence of multiple human papillomavirus types on the risk of genotype-concordant incident infections of the anus and cervix: the hawaii hpv cohort study. | the influence of multiple human papillomavirus (hpv) types on detection of concordant incident hpv infections of the cervix or anus following infection at the other anatomic site was examined in a cohort of 897 women. multiple hpv infections at the anus were not significantly associated with subsequent acquisition of a concordant cervical infection, whereas prior coinfections in the cervix increased risk of a new cervical hpv infection. incident anal hpv infections following concordant cervical ... | 2010 | 21208924 |
| evidence of human papillomavirus in the placenta. | human papillomavirus (hpv) is an epitheliotropic virus typically infecting keratinocytes but also possibly epithelial trophoblastic placental cells. in the present study, we set out to investigate whether hpv can be recovered from transabdominally obtained placental cells to avoid any confounding contamination by hpv-infected cervical cells. thirty-five placental samples from women undergoing transabdominal chorionic villous sampling were analyzed, and we detected hpv-16 and hpv-62 in 2 placenta ... | 2010 | 21208925 |
| management of pre-invasive cervical cancer in low-resource setting. | cervical cancer is one of the health burdens in many developing countries. the advanced knowledge in the past decade reassured the important role of human papillomavirus as the necessary cause of cervical cancer and makes a clear understanding of its natural history. cervical cancer has a long period of pre-invasive stage, and only a small proportion of cervical intraepithelial neoplasia (cin) that can progress to be an invasive lesion. appropriate management of cin can prevent invasive cervical ... | 2004 | 21213526 |
| [prevalence and determinants of lower reproductive tract infections among women aged 25 - 54 years in beijing.] | objective: to determine the prevalence and determinants of the most commonly seen lower reproductive tract infections among women aged 25 - 54 years in beijing. methods: the study population consisted of 6339 women aged 25 - 54 years in 137 communities of beijing. focus of this study was to understand the prevalence of the following diseases as:bacterial vaginosis, trichomoniasis and vulvovaginal candidiasis. in addition to their prevalence rates, a generalized equation for estimation was used t ... | 2010 | 21215070 |
| recurrent laryngeal papillomatosis: successful treatment with human papillomavirus vaccination. | the authors describe the case of a 5-year-old girl with recurrent laryngeal papillomatosis (rlp) due to human papillomavirus (hpv) type 11, who required frequent surgical treatment. complete recovery occurred after hpv vaccination (gardasil). confirmed remission of rlp has continued during the 17 months of follow-up since vaccination. the authors conclude that hpv vaccination may represent a new therapeutic option in this situation. | 2011 | 21220258 |
| population-based frequency assessment of hpv-induced lesions in patients with borderline pap tests in the emilia-romagna region: the pater study. | the pater study assessed the frequency of high-risk (hr) and low-risk (lr) human papillomavirus (hpv) in hpv-induced lesions in patients with borderline cytology. | 2011 | 21222568 |
| molecular characterization of late stomal recurrence following total laryngectomy. | the goal was to determine recurrent or second primary status for late stomal malignancies, 16 and 17 years post-total laryngectomy in two laryngeal squamous cell carcinoma (lscc) patients, based on dna methylation signatures and hpv typing. adopting a literature review based definition of late stomal recurrences as new primaries at the site of the stoma or neopharynx occurring >5 years after total laryngectomy, we employed a multi-gene candidate approach to examine promoter methylation in 24 tum ... | 2011 | 21225233 |
| identification of differential expressed transcripts in cervical cancer of mexican patients. | the aim of this study was to identify the gene expression profile in biopsies of patients with cervical intraepithelial neoplasia (cin) 1, cin 2, cin 3, and microinvasive cancer by suppression subtractive hybridization and southern blotting. after analyzing 1,800 cdna clones, we found 198 upregulated genes, 166 downregulated, and no significant change of gene expression in 86 clones (p = 0.005). these results were validated by northern blot analysis (p = 0.0001) in the identification of 28 overe ... | 2011 | 21225484 |